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| Product | Description | |
|---|---|---|
| 4-Chloro-6-(2-chloro-ethoxy)-7-(2-methoxy-ethoxy)-quinazoline | 4-Chloro-6-(2-chloro-ethoxy)-7-(2-methoxy-ethoxy)-quinazoline. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| 4-Chloro-6-methoxy-quinazoline ≥97% (HPLC) | 4-Chloro-6-methoxy-quinazoline ≥97% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 250mg, 1g, 2.5g. US Biological Life Sciences. | Worldwide |
| 4-Chloro-7-(2-chloro-ethoxy)-6-(2-methoxy-ethoxy)-quinazoline | 4-Chloro-7-(2-chloro-ethoxy)-6-(2-methoxy-ethoxy)-quinazoline. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 6-(Benzyloxy)-4-(3-chloro-4-fluorophenylamino)-7-methoxy-quinazoline | 6-(Benzyloxy)-4-(3-chloro-4-fluorophenylamino)-7-methoxy-quinazoline (CAS# 913819-12-2 ) is a useful research chemical. Synonyms: N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(phenylmethoxy)-4-quinazolinamine. Grades: 95 %. CAS No. 913819-12-2. Molecular formula: C22H17ClFN3O2. Mole weight: 409.84. |  |
| 7-Methoxy-4-(pyridin-3-yl)-6-[2-(quinolin-2-yl)ethoxy]quinazoline | 7-Methoxy-4-(pyridin-3-yl)-6-[2-(quinolin-2-yl)ethoxy]quinazoline is a potent and selective compound in the phosphodiesterase 10A (PDE10A) inhibitor lead series for schizophrenia therapy. Group: Biochemicals. Alternative Names: 7-methoxy-4- (3-pyridinyl) -6-[2- (2-quinolinyl) ethoxy]quinazoline. Grades: Highly Purified. CAS No. 1006890-01-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Aurora Kinase Inhibitor VI, ZM447439 (4-(4-(N-Benzoylamino)anilino)-6- methoxy-7- (3- (1-morpholino) propoxy) quinazoline) | A cell-permeable quinazoline compound that targets the ATP binding pocket and an adjacent cleft and acts as a potent and reversible inhibitor of Aurora A and Aurora B (IC50=110 and 130nM, respectively) with moderate to excellent selectivity among closely related 16-kinase panel (IC50=0.88, 1.03 and 1.79uM for Lck, Src and MEK1, respectively, and IC50>10uM for Cdk1/2/4, Plk1, Chk1). Blocks phosphorylation of Histone H3-Ser10 in Xenopus cycling egg extracts at 20uM, and reduces mitotic spindle assembly. Shown to repress kinetochore localization of BubR1, Cenp-E, and Mad2, and arrest the growth of proliferating tumor cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 331771-20-1. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Desmethyl Erlotinib Acetate (6-(2-Acetoxy-ethoxy)-4-(3-ethynyl-phenylamino)-7-(2-methoxy-ethoxy)-quinazoline) | Desmethyl Erlotinib derivative. Group: Biochemicals. Alternative Names: 6-(2-Acetoxy-ethoxy)-4-(3-ethynyl-phenylamino)-7-(2-methoxy-ethoxy)-quinazoline. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| N4-(3-chloro-2-fluorophenyl)-7-methoxy-4,6-quinazolinediamine | One of the impurities of Dacomitinib. Dacomitinib, aslo known as PF-299 and PF-00299804 or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Synonyms: Dacomitinib Impurity 2F3LAJ. Grades: ≥95%. CAS No. 1221892-23-4. Molecular formula: C15H12ClFN4O. Mole weight: 318.73. | |
| N4-(3-Chloro-4-Fluorophenyl)-7-Methoxyquinazoline-4,6-Diamine | An impurity of Afatinib, a medication used to treat non-small cell lung carcinoma (NSCLC). Synonyms: N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-aminoquinazolin-4-amine; 4,6-Quinazolinediamine, N4-(3-chloro-4-fluorophenyl)-7-methoxy-; Afatinib Impurity JYJ-2. Grades: ≥95%. CAS No. 179552-75-1. Molecular formula: C15H12ClFN4O. Mole weight: 318.73. | |
| AM-2099 | AM-2099 is a potent and selective inhibitor of voltage-gated sodium channel Nav1.7 (IC50 = 0.16 μM) with excellent selectivity against hNav1.5 (IC50 > 30 uM). Synonyms: 4-[2-methoxy-4-(trifluoromethyl)phenyl]-N-(1,3-thiazol-2-yl)quinazoline-7-sulfonamide; AM-2099; AM2099; AM 2099. CAS No. 1443373-17-8. Molecular formula: C19H13F3N4O3S2. Mole weight: 466.46. | |
| Cediranib maleate | Cediranib maleate is a highly potent VEGFR(KDR) inhibitor with IC50 of <1 nM. It also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM. It inhibits VEGF-stimulated proliferation with IC50 of 0.4 nM in vitro. It suppresses PDGF-AA with IC50 of 0.04 μM in MG63 cell lines. It even suppresses tubule sprouting at subnanomolar concentrations and inhibits VEGF-induced angiogenesis in vivo. It causes hypertrophy in bone growth plate and prevents luteal development in ovary. It shows broad spectrum activity in human tumor models at doses that are well tolerated. It causes regression of vascular tissues in human lung tumor xenografts. Synonyms: AZD 2171 maleate; Recentin; 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline maleate. Grades: >98%. CAS No. 857036-77-2. Molecular formula: C29H31FN4O7. Mole weight: 566.6. | |
| Dacomitinib Impurity SFAJ | One of the impurities of Dacomitinib. Dacomitinib, aslo known as PF-299 and PF-00299804 or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Synonyms: Dacomitinib Impurity SFAJ; CS-0255393; F83329; N4-(3,4-Difluorophenyl)-7-methoxyquinazoline-4,6-diamine; N4-(3,4-DIFLUOROPHENYL)-7-METHOXY-QUINAZOLINE-4,6-DIAMINE; N4-(3,4-Difluorophenyl)-7-methoxyquinazoline-4,6-diamine (Dacomitinib Impurity). Grades: ≥95%. CAS No. 2117703-26-9. Molecular formula: C15H12F2N4O. Mole weight: 302.28. | |
| Desmethyl erlotinib acetate | Desmethyl erlotinib acetate. Group: Biochemicals. Alternative Names: 6-(2-Acetoxy-ethoxy)-4-(3-ethynyl-phenylamino)-7-(2-methoxy-ethoxy)quinazoline; 2- [ [4- [ (3-Ethynylphenyl) amino] -7- (2-methoxyethoxy) -6-quinazolinyl] oxy] ethanol 1-acetate; 2- [ [4- [ (3-ethynylphenyl) amino] -7- (2-methoxyethoxy) -6-quinazolinyl] oxy] ethanol acetate ester. Grades: Highly Purified. CAS No. 183320-15-2. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C23H23N3O5. US Biological Life Sciences. | Worldwide |
| Erlotinib Impurity 19 | Erlotinib Impurity 19. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-methoxy-6,7-bis(2-methoxyethoxy)quinazoline. CAS No. 1312937-41-9. Molecular Formula: C15H20N2O5. Mole Weight: 308.14. Catalog: APB1312937419. |  |
| Gefitinib Impurity VII | An impurity of Gefitinib. Gefitinib is an EGFR inhibitor. It is used for the treatment of certain breast, lung and other cancers. Synonyms: 3,4-Dihydro-4-oxo-6-acetoxy-7-methoxyquinazoline; 6-(Acetyloxy)-7-methoxy-4(3H)-quinazolinone; 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate; Gefitinib interMidiate IV; 7-Methoxy-4-oxo-3,4-dihydroquinazolin-6-yl acetate. Grades: > 95%. CAS No. 179688-53-0. Molecular formula: C11H10N2O4. Mole weight: 234.21. | |
| Gefitinib Impurity X | Synonyms: 6-Acetoxy-4-chloro-7-methoxyquinazoline; 4-Chloro-6-acetoxy-7-methoxyquinazoline; 4-Chloro-7-methoxy-6-quinazolinol 6-acetate; Gefitinib interMediate V; 6-Quinazolinol, 4-chloro-7-Methoxy-, 6-acetate; N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropox. Grades: > 95%. CAS No. 230955-75-6. Molecular formula: C11H9ClN2O3. Mole weight: 252.66. | |
| Lapatinib 2-Fluoro Impurity | Synonyms: Lapatinib 2-Fluoro Impurity; 3-Desfluoro 2-Fluoro Lapatinib; N- (3-Chloro-4- ( (2-fluorobenzyl) oxy) phenyl) -6- (5- ( ( (2- (methylsulfonyl) ethyl) amino) methyl) furan-2-yl) quinazolin-4-amine; N-[3-chloro-4-[ (2-fluorophenyl) methoxy]phenyl]-6-[5-[ (2-methylsulfonylethylamino) methyl]furan-2-yl]quinazolin-4-amine; N-[3-Chloro-4-[(2-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine; SCHEMBL11962955; AUSNUFCAWIGPSG-UHFFFAOYSA-N; N-{3-chloro-4-[ (2-fluorobenzyl) oxy]phenyl}-6-[5- ({[2- (methylsulfonyl) ethyl]amino}methyl) furan-2-yl]quinazoline-4-amine. Grades: > 95%. CAS No. 1393112-45-2. Molecular formula: C29H26ClFN4O4S. Mole weight: 581.07. | |
| MPS1/TTK Inhibitor | MPS1/TTK inhibitor is an inhibitor of monopolar spindle 1 (MPS1/TTK), a dual-specificity kinase playing an essential role in mitotic spindle checkpoint signaling that is overexpressed in certain cancerous tumors. Synonyms: N-(2,6-diethylphenyl)-4,5-dihydro-8-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-1-methyl-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide. Grades: ≥98%. CAS No. 1202055-39-7. Molecular formula: C33H40N8O2. Mole weight: 580.72. | |
| N-[3-Chloro-4-[ (3-fluorobenzyl) oxy]phenyl]-6-iodoquinazolin-4-amine | Lapatinib intermediate. Group: Biochemicals. Alternative Names: N-[3-Chloro-4-[ (3-fluorophenyl) methoxy]phenyl]-6-iodo-4-quinazolinamine; 6-Iodo-4-[3-chloro-4- (3-fluorobenzyloxy) anilino]quinazoline. Grades: Highly Purified. CAS No. 231278-20-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| N-Demethyl vandetanib | N-Demethyl vandetanib. Group: Biochemicals. Alternative Names: N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-(4-piperidinylmethoxy)-4-quinazolinamine; 4- (4-Bromo-2-fluoroanilino) -6-methoxy-7-[ (piperidin-4-yl) methoxy]quinazoline. Grades: Highly Purified. CAS No. 338992-12-4. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C21H22BrFN4O2. US Biological Life Sciences. | Worldwide |
| N-Desmethyl Vandetanib | N-Desmethyl Vandetanib is a metabolite of Vandetanib. Vandetanib is an antitumor drug used for the treatment of medullary thyroid cancer. Vandetanib effects through inhibiting vascular endothelial growth factor receptor-2 (VEGFR), epidermal growth factor receptor (EGFR) and the RET-tyrosine kinase activity. Synonyms: N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-(4-piperidinylmethoxy)-4-quinazolinamine; 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(piperidin-4-yl)methoxy]quinazoline. CAS No. 338992-12-4. Molecular formula: C21H22BrFN4O2. Mole weight: 461.34. | |
| O-Desmorpholinopropyl Gefitinib | A metabolite of Gefitinib. Group: Biochemicals. Alternative Names: 4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinol;4-(3-Chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline. Grades: Highly Purified. CAS No. 184475-71-6. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| RG3039 | RG3039 is a potent DcpS inhibitor. It is used for the treatment for spinal muscular atrophy(SMA), which is caused by deletion or mutation of both copies of the SMN1 gene. It improves motor function in SMA mice. It also showed activity to improve survival, function and motor unit pathologies in two SMA mouse models. It was developed by Repligen and now in Clinic Phase 1 with no progress. Uses: Rg3039 is used for the treatment for spinal muscular atrophy(sma). Synonyms: RG3039; RG 3039; RG-3039; PF06687859; PF 06687859; PF-06687859. 5-((1-(2,6-dichlorobenzyl)piperidin-4-yl)methoxy)quinazoline-2,4-diamine;5-[[1-[(2,6-dichlorophenyl)methyl]piperidin-4-yl]methoxy]quinazoline-2,4-diamine. Grades: >98 %. CAS No. 1005504-62-0. Molecular formula: C21H23Cl2N5O. Mole weight: 432.35. | |
| Vandetanib | Vandetanib is a once-daily oral inhibitor of vascular endothelial growth factor receptor-2 and epidermal growth factor receptor kinase activity. The activity of Vandetanib plus Docetaxel was assessed in patients with previously treated non-small-cell lung cancer (NSCLC). Group: Biochemicals. Alternative Names: N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine; 4- (4-Bromo-2-fluoroanilino) -6-methoxy-7-[ (1-methylpiperidin-4-yl) methoxy]quinazoline; ZD 6474; Zactima. Grades: Highly Purified. CAS No. 443913-73-3. Pack Sizes: 100mg, 250mg, 500mg, 1g. Molecular Formula: C22H24BrFN4O2, Molecular Weight: 475.35. US Biological Life Sciences. | Worldwide |
| Vandetanib | Vandetanib (ZD6474) is a potent inhibitor of VEGFR2 with IC50 of 40 nM. Uses: Antineoplastic. Synonyms: ZD6474; ZD 6474; ZD-6474; 4-Quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine; 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline; AZD 6474; AZD-6474; AZD6474; Caprelsa; CH 331; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-(N-methylpiperidin-4-ylmethoxy)quinazolin-4-amine; Zactima. Grades: >98%. CAS No. 443913-73-3. Molecular formula: C22H24BrFN4O2. Mole weight: 475.35. | |
| 1,3-Dioxolo[4,5-g]quinazolin-8(7H)-one,4-methoxy-6-methyl- | Heterocyclic Organic Compound. CAS No. 114795-70-9. Catalog: ACM114795709. |  |
| 1-(4-((3-Chloro-4-fluorocyclohexyl)amino)-7-methoxyquinazolin-6-yl)-5-hydroxypyrrolidin-2-one | One of the impurities of Dacomitinib. Dacomitinib, aslo known as PF-299 and PF-00299804 or PF299804, is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Synonyms: 2-Pyrrolidinone, 1-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-5-hydroxy-; Dacomitinib Impurity WYQJ. Grades: ≥95%. CAS No. 2190490-31-2. Molecular formula: C19H16ClFN4O3. Mole weight: 402.81. | |
| 2,4-Difluoro-N-[2-methoxy-5-[4-(4-morpholinyl)-6-quinazolinyl]-3-pyridinyl]benzenesulfonamide | Heterocyclic Organic Compound. Alternative Names: CHEMBL3121327, 1093818-24-6, GSK series, SCHEMBL3120273, BITYGNDFPWCLCP-UHFFFAOYSA-N, DB-059897, KB-295535, 2,4-difluoro-N-(2-methoxy-5-(4-morpholinoquinazolin-6-yl)pyridin-3-yl)benzenesulfonamide, 2,4-difluoro-N-[2-methoxy-5-(4-morpholinoquinazolin-6-yl)-3-pyridyl]benzenesulfonamide, 2,4-difluoro-N-[2-methoxy-5-[4-(4-morpholinyl)-6-quinazolinyl]-3-pyridinyl]Benzenesulfonamide, 2,4-difluoro-N-{2-(methyloxy)-5-[4-(4-morpholinyl)-6-quinazolinyl]-3-pyridinyl}benzenesulfonamide, benzenesulfonamide,2,4-difluoro-n-[2-methoxy-5-[4-(4-morpholinyl)-6-quinazolinyl]-3-pyridinyl]-. CAS No. 1093818-24-6. Molecular formula: C24H21F2N5O4S. Mole weight: 513.516446 [g/mol]. Purity: 0.96. IUPACName: 2,4-difluoro-N-[2-methoxy-5-(4-morpholin-4-ylquinazolin-6-yl)pyridin-3-yl]benzenesulfonamide. Canonical SMILES: COC1=C (C=C (C=N1)C2=CC3=C (C=C2)N=CN=C3N4CCOCC4)NS (=O) (=O)C5=C (C=C (C=C5)F)F. Catalog: ACM1093818246. | |
| 2-Cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine | UNC0638 is a selective inhibitor of G9a and G9a-like protein (GLP), also known as EHMT1, with IC50's in the very low (<20) nM range. It also exhibits very weak activity against JMJD2E (IC50 ~4.5uM), but the selectivity for G9a and GLP is over 200-fold. UNC0638 was inactive against SUV39H1, SUV39H2, EZH2), SETD7, MLL, SMYD3, DOT1L, SETD8, PRDM1, PRMT1 and PRMT3. UNC0638 exhibits only extremely weak inhibition of DNMT1 (IC50>100uM). Group: Biochemicals. Alternative Names: UNC0638. Grades: Highly Purified. CAS No. 1255580-76-7. Pack Sizes: 10mg. Molecular Formula: C30H47N5O2, Molecular Weight: 509.73. US Biological Life Sciences. | Worldwide |
| 2-Mercapto-3-(2-methoxy-phenyl)-3H-quinazolin-4-one | Heterocyclic Organic Compound. Alternative Names: 2-Mercapto-3-(2-methoxy-phenyl)-3H-quinazolin-4-one, 3-(2-methoxyphenyl)-2-sulfanylquinazolin-4(3H)-one, 1031-67-0, 3-(2-methoxyphenyl)-2-sulfanyl-3-hydroquinazolin-4-one, ZINC00210306, AC1LDZMK, AC1Q4EHE, CBMicro_015964, AC1Q6JF9, Oprea1_325749, Oprea1_368559, Oprea1_831344, STOCK2S-27005, CTK1I8395, CTK4A1787, MolPort-000-869-265, MolPort-003-249-681, AR-1E6327, SBB038357, STK305786. CAS No. 1031-67-0. Molecular formula: C15H12N2O2S. Mole weight: 284.332980 [g/mol]. Purity: 0.96. IUPACName: 3-(2-methoxyphenyl)-2-sulfanylidene-1H-quinazolin-4-one. Canonical SMILES: COC1=CC=CC=C1N2C(=O)C3=CC=CC=C3NC2=S. Density: 1.4g/cm³. Catalog: ACM1031670. | |
| 3-Desmorpholinyl-3-hydroxyethylamino gefitinib | 3-Desmorpholinyl-3-hydroxyethylamino gefitinib. Group: Biochemicals. Alternative Names: 2- [ [3- [ [4- [ (3-Chloro-4-fluorophenyl) amino] -7-methoxy-6-quinazolinyl] oxy] propyl] amino] ethanol. Grades: Highly Purified. CAS No. 847949-56-8. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C20H22ClFN4O3. US Biological Life Sciences. | Worldwide |
| 3-Desmorpholinyl-3-hydroxyethylamino Gefitinib | 3-Desmorpholinyl-3-hydroxyethylamino Gefitinib is a metabolite of Gefitinib. Synonyms: Ethanol, 2-[[3-[[4-[(3-chloro-4-fluorophenyl)aMino]-7-Methoxy-6-quinazolinyl]oxy]propyl]aMino]-; 2- [ [3- [ [4- [ (3-Chloro-4-fluorophenyl) aMino] -7-Methoxy-6-quinazolinyl] oxy] propyl] aMino] ethanol; Gefitinib iMpurity D; 2-((3-((4-((3-chloro-4-fluorophenyl)amino)-7-. Grades: > 95%. CAS No. 847949-56-8. Molecular formula: C20H22ClFN4O3. Mole weight: 420.87. | |
| 4(3H)-Quinazolinone,2-methoxy- | Heterocyclic Organic Compound. Alternative Names: 2-Methoxyquinazolin-4(3H)-one, 2-methoxyquinazolin-4-ol, 1011-24-1, 4(3H)-Quinazolinone, 2-methoxy-, NSC401252, 2-methoxy-4-quinazolinol, SureCN148952, AC1L80FK, 2-methoxy-1H-quinazolin-4-one, CTK7B2100, CTK8C1577, MolPort-005-980-633, ANW-66916, SBB089149, ZINC01593943, AKOS006343767, AKOS016007980, AG-B-91373, MCULE-6482957980, NSC-401252. CAS No. 1011-24-1. Molecular formula: C9H8N2O2. Mole weight: 176.172020 [g/mol]. Purity: 0.96. IUPACName: 2-methoxy-1H-quinazolin-4-one. Canonical SMILES: COC1=NC(=O)C2=CC=CC=C2N1. Density: 1.32g/cm³. Catalog: ACM1011241. | |
| 4-[(4-Bromo-2-fluorophenyl)amino]-6-methoxy-7-Quinazolinol | 4-[(4-Bromo-2-fluorophenyl)amino]-6-methoxy-7-Quinazolinol. Group: Biochemicals. Grades: Highly Purified. CAS No. 196603-96-0. Pack Sizes: 1g. Molecular Formula: C15H11BrFN3O2, Molecular Weight: 364.17. US Biological Life Sciences. | Worldwide |
| 4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]-benzoic Acid | 4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]-benzoic Acid. Group: Biochemicals. Alternative Names: QZN-46; QNZ46; 4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]-Benzoic Acid; NMDA Antagonist VIII. Grades: Highly Purified. CAS No. 1237744-13-6. Pack Sizes: 25mg. Molecular Formula: C24H17N3O6, Molecular Weight: 443.41. US Biological Life Sciences. | Worldwide |
| 4-Defluoro-4-hydroxy gefitinib | 4-Defluoro-4-hydroxy gefitinib. Group: Biochemicals. Alternative Names: 2-Chloro-4- [ [7-methoxy-6- [3- (4-morpholinyl) propoxy] -4-quinazolinyl] amino] phenol. Grades: Highly Purified. CAS No. 847949-50-2. Pack Sizes: 10mg, 25mg, 50mg, 100mg. Molecular Formula: C22H25ClN4O4. US Biological Life Sciences. | Worldwide |
| 4-Defluoro-4-hydroxy Gefitinib | 4-Defluoro-4-hydroxy Gefitinib is a metabolite of Gefitinib. Synonyms: 2-Chloro-4-[[7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenol; Phenol, 2-chloro-4-[[7-Methoxy-6-[3-(4-Morpholinyl)propoxy]-4-quinazolinyl]aMino]-; 2-Chloro-4-[[7-Methoxy-6-[3-(4-Morpholinyl)propoxy]-4-quinazolinyl]aMino]phenol; Gefitinib iM. Grades: > 95%. CAS No. 847949-50-2. Molecular formula: C22H25ClN4O4. Mole weight: 444.92. | |
| (4S) -3,4-dihydro-4-phenyl-3- [1- [[3-(trifluoro Methoxy group) phenyl] methyl] -4-piperidinyl] -2 (1H)-Quinazolinone | (4S) -3,4-dihydro-4-phenyl-3- [1- [[3-(trifluoro Methoxy group) phenyl] methyl] -4-piperidinyl] -2 (1H)-Quinazolinone. Uses: For analytical and research use. Group: Impurity standards. CAS No. 877606-63-8. Molecular Formula: C27H26F3N3O2. Mole Weight: 481.52. Catalog: APB877606638. | |
| 4SC-203 | 4SC-203 is a multikinase inhibitor with potential antineoplastic activity. Multikinase inhibitor 4SC-203 selectively inhibits FMS-related tyrosine kinase 3 (FLT3/STK1), FLT3 mutated forms, and vascular endothelial growth factor receptors (VEGFRs). This may result in the inhibition of angiogenesis and cell proliferation in tumor cells in which these kinases are upregulated. FLT3 (FLK2), a class III tyrosine kinase receptor, is overexpressed or mutated in most B lineage and acute myeloid leukemias (AML). VEGFRs, tyrosine kinase receptors, are overexpressed in a variety of tumor cell types and play key roles in angiogenesis. Group: Inhibitors. Alternative Names: 4SC203; 4SC-203; 4SC 203; SC71710; SC-71710; SC 71710. CAS No. 895533-09-2. Molecular formula: C33H38N8O4S. Mole weight: 642.77. Appearance: Solid powder. Purity: >98%. IUPACName: 1-(2-methoxy-5-methylphenyl)-3-(6-((6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinazolin-4-yl)amino)benzo[d]thiazol-2-yl)urea. Canonical SMILES: O=C (NC1=NC2=CC=C (NC3=C4C=C (OC)C (OCCCN5CCN (C)CC5)=CC4=NC=N3)C=C2S1)NC6=CC (C)=CC=C6OC. Catalog: ACM895533092. | |
| 5-[4-[[3-Chloro-4-[ (3-fluorophenyl) methoxy]phenyl]amino]-6-quinazolinyl]-2-furancarboxaldehyde | Lapatinib intermediate. Group: Biochemicals. Alternative Names: [5-[4-[4-[(3-Fluorobenzyl)oxy]-3-chloroanilino]-6-quinazolinyl]-2-furancarboxaldehyde. Grades: Highly Purified. CAS No. 231278-84-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 6-bromo-7-methoxy-4 (3H)-quinazolinone | 6-bromo-7-methoxy-4 (3H)-quinazolinone. Uses: For analytical and research use. Group: Impurity standards. CAS No. 950577-05-6. Molecular Formula: C9H7BrN2O2. Mole Weight: 255.07. Catalog: APB950577056. | |
| 6-Hydroxy doxazosin | 6-Hydroxy doxazosin. Group: Biochemicals. Alternative Names: 1-(4-Amino-6-hydroxy-7-methoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl-piperazine. Grades: Highly Purified. CAS No. 102932-26-3. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C22H23N5O5. US Biological Life Sciences. | Worldwide |
| 6-Hydroxy doxazosin | Heterocyclic Organic Compound. Alternative Names: 6-HYDROXY DOXAZOSIN;1-(4-Amino-6-hydroxy-7-methoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl-piperazine. CAS No. 102932-26-3. Molecular formula: C22H23N5O5. Mole weight: 437.454. Purity: 0.96. IUPACName: [4-(4-amino-6-hydroxy-7-methoxyquinazolin-2-yl)piperazin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone. Canonical SMILES: COC1=C (C=C2C (=C1)N=C (N=C2N)N3CCN (CC3)C (=O)C4COC5=CC=CC=C5O4)O. Catalog: ACM102932263. | |
| 7-Benzyloxy-6-methoxy-3H-quinazolin-4-one 98+% (HPLC) | 7-Benzyloxy-6-methoxy-3H-quinazolin-4-one 98+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 100mg, 250mg, 1g, 5g. US Biological Life Sciences. | Worldwide |
| 7-Hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one | 7-Hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one. Group: Biochemicals. Alternative Names: 7-Hydroxy-6-methoxy-4(3H)-quinazolinone. Grades: Highly Purified. CAS No. 162012-72-8. Pack Sizes: 250mg. Molecular Formula: C9H8N2O3, Molecular Weight: 192.17. US Biological Life Sciences. | Worldwide |
| 7-Hydroxy doxazosin | 7-Hydroxy doxazosin. Group: Biochemicals. Alternative Names: 1-(4-Amino-7-hydroxy-2-methoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl-piperazine. Grades: Highly Purified. CAS No. 102932-25-2. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C22H23N5O5. US Biological Life Sciences. | Worldwide |
| 7-Hydroxy doxazosin | Heterocyclic Organic Compound. Alternative Names: 1-(4-Amino-7-hydroxy-2-methoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl-piperazine. CAS No. 102932-25-2. Molecular formula: C22H23N5O5. Mole weight: 437.45. Purity: 0.96. IUPACName: 4-amino-2-[4-(2,3-dihydro-1,4-benzodioxine-3-carbonyl)piperazin-1-yl]-6-methoxy-1H-quinazolin-7-one. Canonical SMILES: COC1=CC2=C (N=C (NC2=CC1=O)N3CCN (CC3)C (=O)C4COC5=CC=CC=C5O4)N. Catalog: ACM102932252. | |
| 7-Methoxy-3-methyl-6-[2-(quinolin-2-yl)ethoxy]quinazolin-4(3H)-one | 7-Methoxy-3-methyl-6-[2-(quinolin-2-yl)ethoxy]quinazolin-4(3H)-one is a potent and selective compound in the Phosphodiesterase 10A (PDE10A) inhibitor lead series for schizophrenia therapy. Group: Biochemicals. Alternative Names: 7-Methoxy-3-methyl-6-[2-(2-quinolinyl)ethoxy]-4(3H)-quinazolinone. Grades: Highly Purified. CAS No. 1006891-07-1. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 7-Methoxy-4(3H)-quinazolinzone | 7-Methoxy-4(3H)-quinazolinzone. Group: Biochemicals. Grades: Highly Purified. CAS No. 16064-24-7. Pack Sizes: 50mg, 100mg, 250mg, 1g, 2g. Molecular Formula: C9H8N2O2. US Biological Life Sciences. | Worldwide |
| 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin | Gefitinib intermediate. Group: Biochemicals. Alternative Names: 7-Methoxy-6-[3-(4-morpholinyl)propoxy]-. Grades: Highly Purified. CAS No. 199327-61-2. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one | 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one is an intermediate of Gefitinib. Gefitinib is an antineoplastic drug. Gefitinib effectively inhibits all tyrosine phosphorylation sites on EGFR in both the high and low EGFR-expressing cell lines including NR6, NR6M and NR6W cell lines. The phosphorylation sites Tyr1173 and Tyr992 are less sensitive requiring higher concentrations of Gefitinib for inhibition. Synonyms: Gefitinib Impurity 12; 7-methoxy-6-(3-morpholin-4-ylpropoxy)-1H-quinazolin-4-one. CAS No. 199327-61-2. Molecular formula: C16H21N3O4. Mole weight: 319.36. | |
| 7-Methoxy-6-nitroquinazolin-4(3H)-one | Heterocyclic Organic Compound. Alternative Names: 7-methoxy-6-nitroquinazolin-4(3H)-one, 1012057-47-4, SureCN157879, SureCN1766090, CTK8B7483, ANW-57457, ZINC31777068, AKOS016001472, AK-86969, KB-250031. CAS No. 1012057-47-4. Molecular formula: C9H7N3O4. Mole weight: 221.169580 [g/mol]. Purity: 0.96. IUPACName: 7-methoxy-6-nitro-1H-quinazolin-4-one. Canonical SMILES: COC1=C (C=C2C (=C1)NC=NC2=O)[N+] (=O)[O-]. Catalog: ACM1012057474. | |
| 7-Methoxy-N,N-dimethyl-6-[2-(quinolin-2-yl)ethoxy]quinazolin-4-amine | 7-Methoxy-N,N-dimethyl-6-[2-(quinolin-2-yl)ethoxy]quinazolin-4-amine is a potent and selective compound in the phosphodiesterase 10A (PDE10A) inhibitor lead series for schizophrenia therapy. Group: Biochemicals. Alternative Names: 7-Methoxy-N,N-dimethyl-6-[2-(2-quinolinyl)ethoxy]-4-quinazolinamine. Grades: Highly Purified. CAS No. 1006890-24-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 8-Methoxy-2-methyl-4(3H)-quinazolinone | 8-Methoxy-2-methyl-4(3H)-quinazolinone. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Afatinib Impurity 5 | An analogue of Afatinib. Synonyms: 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)?-7-methoxy-6-nitro-. Grades: > 95%. CAS No. 179552-74-0. Molecular formula: C15H10ClFN4O3. Mole weight: 348.72. | |
| AST-1306 | AST-1306 is a selective irreversible inhibitor of the epidermal growth factor receptor (EGFR) 1 and 2. Studies show that AST-1306 inhibited the enzymatic activities of wild-type EGF) and ErbB2 as well as EGFR resistant mutant in both cell-free and cell-based systems. AST-1306 was more effective in inhibiting tumors with ErbB2-overexpressing cells than EGFR-overexpressing tumor. Group: Biochemicals. Alternative Names: N- [4- [ [3-Chloro-4- [ (3-fluorobenzyl) oxy] phenyl] amino] quinazolin-6-yl] acrylamide; N-[4-[[3-Chloro-4-[ (3-fluorophenyl) methoxy]phenyl]amino]-6-quinazolinyl]-2-propenamide; ALS1306; AST 1306; AST 6. Grades: Highly Purified. CAS No. 897383-62-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| BI-3406 | BI-3406 is Potent & Selective SOS1:KRAS Inhibitor (IC50=5 nM), which Opens a New Approach for Treating KRAS-Driven Tumours. BI 3406 selectively binds to SOS1 and blocks the interaction with KRAS, irrespective of the KRAS mutation. BI 3406 causes RAS GTP and pERK reduction and inhibits cell growth of KRAS mutated cell lines, carrying most of the typical KRAS mutations (i.e. G12D, G12V, G13D and others). BI 3406, when administered orally to tumour bearing mice, causes a dose dependent tumour static effect that can be converted into regressions when combined with MEK1 inhibition. Group: Inhibitors. Alternative Names: BI-3406; BI 3406; BI3406. CAS No. 2230836-55-0. Molecular formula: C23H25F3N4O3. Mole weight: 462.47. Appearance: Solid powder. Purity: >98%. IUPACName: N-((R)-1-(3-amino-5-(trifluoromethyl)phenyl)ethyl)-7-methoxy-2-methyl-6-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-4-amine. Canonical SMILES: C[C@H] (C1=CC (N)=CC (C (F) (F)F)=C1)NC2=C3C (C=C (OC)C (O[C@H]4CCOC4)=C3)=NC (C)=N2. Catalog: ACM2230836550. | |
| Copanlisib | Copanlisib is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. BAY 80-6946 inhibits the activation of the PI3K signaling pathway, which may result in the inhibition of tumor cell growth and survival in susceptible tumor cell populations. Synonyms: BAY 80-6946; Aliqopa; BAY-80-6946; 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide. Grades: ≥98%. CAS No. 1032568-63-0. Molecular formula: C23H28N8O4. Mole weight: 480.529. | |
| Copanlisib | Other Alkaloids. Alternative Names: Aliqopa. CAS No. 1032568-63-0. Molecular formula: C23H28N8O4. Mole weight: 480.52. Purity: 98%+. IUPACName: 2-Amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydro-1H-imidazo[1,2-c]quinazolin-5-ylidene]pyrimidine-5-carboxamide. Canonical SMILES: COC1=C (C=CC2=C3NCCN3C (=NC (=O)C4=CN=C (N=C4)N)N=C21)OCCCN5CCOCC5. Catalog: ACM1032568630. | |
| CP654577 | CP654577 is a selective p185(erbB2) kinase inhibitor. It could reduce the levels of the activated form of mitogen-activated protein kinase of SKBr3 human breast cancer cells. Synonyms: CP-654577; CP 654577; 3-Azabicyclo(3.1.0)hexane-6-methanol, 3-((4-(4-((3-methoxy-4-phenoxyphenyl)amino)-6-quinazolinyl)phenyl)methyl)-, (1alpha,5alpha,6alpha)-. Grades: 98%. CAS No. 639087-64-2. Molecular formula: C34H32N4O3. Mole weight: 544.65. | |
| CUDC-101 | CUDC-101 is a potent multi-acting HDAC (histone deacetylase), EGFR (epidermal growth factor receptor), and HER2 ( human epidermal growth factor receptor 2) inhibitor for the treatment of cancer. Group: Biochemicals. Alternative Names: 7-[[4-[(3-Ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-N-hydroxyheptanamide; 7-[[4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl]oxy]-N-hydroxyheptanamide. Grades: Highly Purified. CAS No. 1012054-59-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Epertinib | Epertinib, also known as S-222611, is a potent, oral, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4, with IC50s of 1.48 nM, 7.15 nM and 2.49 nM, respectively, currently under trials in patients with solid tumours. It also inhibited intracellular kinase activity and the growth of EGFR-expressing and HER2-expressing cancer cells. Synonyms: Epertinib; S-22611; S22611; S 22611; (R, Z) -1- (4- ( (3-chloro-4- ( (3-fluorobenzyl) oxy) phenyl) amino) quinazolin-6-yl) but-2-yn-1-one O-morpholin-3-ylmethyl oxime; Epertinib; S-222611; S222611; S 222611; 2-Butyn-1-one, 1-(4-((3-chloro-4-((3-fluorophenyl)methoxy)phenyl)amino)-6-quinazolinyl)-, O-((3R)-3-morpholinylmethyl)oxime, (1Z)-; N-{3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl}- 6-[(1Z)-N-{[(3R)-morpholin-3-yl]methoxy}but- 2-ynimidoyl]quinazolin-4-amine. CAS No. 908305-13-5. Molecular formula: C30H27ClFN5O3. Mole weight: 559.178. | |
| Erlotinib Impurity 44 | Erlotinib Impurity 44. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-(3-ethynylphenyl)-6-methoxy-7-(2-methoxyethoxy)quinazolin-4-amine. Molecular Formula: C20H19N3O3. Mole Weight: 349.38. Catalog: APB05337. | |
| Erlotinib Impurity E | Erlotinib Impurity E. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-(3-ethynylphenyl)-7-methoxy-6-(2-methoxyethoxy)quinazolin-4-amine hydrochloride. Molecular Formula: C20H20ClN3O3. Mole Weight: 385.84. Catalog: APB05340. | |
| GDC6036 | GDC-6036, also known as RG6330, is an orally bioavailable, highly potent and selective KRAS G12C inhibitor, with a median IC50 in the sub-nanomolar range and greater than 18,000-fold selectivity for G12C versus non-G12C cell lines. GDC-6036 demonstrates greater potency and selectivity compared with other KRAS G12C inhibitors in vitro, and complete tumor growth inhibition in multiple KRAS G12C-positive cell lines and in xenograft mouse models. We will highlight the research program that led to the discovery and optimization of GDC-6036, which is currently in clinical development. Group: Inhibitors. Alternative Names: GDC-6036; GDC 6036; GDC6036; RG6330; RG-6330; RG 6330. CAS No. 2417987-45-0. Molecular formula: C29H32ClF4N7O2. Mole weight: 622.07. Appearance: To be determined. Purity: >98%. IUPACName: 1-((S)-4-(7-((R)-6-amino-4-methyl-3-(trifluoromethyl)pyridin-2-yl)-6-chloro-8-fluoro-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)quinazolin-4-yl)-3-methylpiperazin-1-yl)prop-2-en-1-one. Canonical SMILES: NC1=N[C@] ([C@]2=C (C=C3C (N=C (N=C3N4[C@H] (CN (CC4)C (C=C)=O)C)OC[C@H]5N (CCC5)C)=C2F)Cl)=C (C (C)=C1)C (F) (F)F. Catalog: ACM2417987450. | |
| Gefitinib-d3 | Labeled Gefitinib. Gefitinib is an antineoplastic. Group: Biochemicals. Alternative Names: N-(3-Chloro-4-fluorophenyl)-7-(methoxy-d3)-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine; Iressa-d3; ZD 1839-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Gefitinib impurity 29 | Gefitinib impurity 29. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine. CAS No. 184475-35-2. Molecular Formula: C22H24ClFN4O3. Mole Weight: 446.9. Catalog: APB184475352. | |
| Gefitinib impurity H | Gefitinib impurity H. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 7-methoxy-6-(3-morpholinopropoxy)quinazolin-4(3H)-one. CAS No. 199327-61-2. Molecular Formula: C16H21N3O4. Mole Weight: 319.36. Catalog: APB199327612. | |
| Gefitinib Impurity P | Gefitinib Impurity P. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)-N-(3-morpholinopropyl)quinazolin-4-amine. CAS No. 1502829-45-9. Molecular Formula: C29H37ClFN5O4. Mole Weight: 574.09. Catalog: APB1502829459. | |
| Gefitinib Impurity VIII | Synonyms: 4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinol 6-acetate; 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate; 6-Quinazolinol,4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-, 6-acetate; Gefitinib intermediate VI. Grades: > 95%. CAS No. 788136-89-0. Molecular formula: C17H13ClFN3O3. Mole weight: 361.76. | |
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