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Roscovitine-related purine with no activity on CDKs (used as control for roscovitine). Selectively and potently increases production of extracellular Abeta42 and decreases production of extracellular Abeta38 in cultured cells. Extracellular Abeta40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting gamma-secretase activity toward Abeta42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains. Tool to detect inhibitors of Aftin-induced actions (potential anti-AD compounds). Binds pyridoxal kinase. Group: Biochemicals. Grades: Highly Purified. CAS No. 866893-90-5. Pack Sizes: 1mg, 5mg, 25mg. US Biological Life Sciences.
Roscovitine-related purine with no activity on CDKs (used as control for roscovitine). Selectively and potently increases production of extracellular Ab42 and decreases production of extracellular Ab38 in cultured cells. Extracellular Ab40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting gamma-secretase activity toward Ab42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains. Tool to detect inhibitors of Aftin-induced actions (potential anti-AD compounds). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg, 25mg. US Biological Life Sciences.
Worldwide
α-Amylcinnamaldehyde-methyl anthranilate
Synonyms: 2-[[2-(phenylmethylene)heptylidene]amino]-benzoicacimethylester; amylcinnamylidenemethylanthranilate; Benzoicacid,2-[[2-(phenylmethylene)heptylidene]amino]-,methylester; methyln-(beta-pentylcinnamylidene)anthranilate; n-(2-benzylideneheptylidene)-anthranilic. CAS No. 68527-78-6. Molecular formula: C22H25 N O2. Mole weight: 335.48.
Methyl N-Amyl Ketone - Surface Coatings. SUPPLIERS TO BUSINESS CUSTOMERS ONLY.
North America & APAC
N-Amyl-N-methylnitrosamine
A potent esophageal carcinogen. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
1-(Dimethylamino)-2-methyl-2-butanol
1-(Dimethylamino)-2-methylbutan-2-ol is an intermediate in the synthesis of Amylocaine Hydrochloride which, is used mostly in spinal anesthesia. Group: Biochemicals. Grades: Highly Purified. CAS No. 74347-10-7. Pack Sizes: 5g, 10g. Molecular Formula: C7H17NO. US Biological Life Sciences.
2-Ethyl-2-methyl-1,3-dioxolane is used as a reagent in the synthesis of Strychnine Hydrochloride (S687710); a compound that acts as an antagonist for cholinesterases and beta amyloid aggregation. Also used as a reagent in the study of the prodrugs of peptide aldehyde as proteasome inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 126-39-6. Pack Sizes: 1g, 10g. Molecular Formula: C6H12O2, Molecular Weight: 116.16. US Biological Life Sciences.
Worldwide
2-Methyl-1-pentylindole
2-Methyl-1-pentylindole. Group: Biochemicals. Alternative Names: 1-n-Amyl-2-methylindole; 2-Methyl-1-pentyl-1H-indole. Grades: Highly Purified. CAS No. 42951-36-0. Pack Sizes: 1g. Molecular Formula: C14H19N, Molecular Weight: 201.31. US Biological Life Sciences.
Worldwide
2-Phenyl-5-methyloxazole-4-carboxylic Acid
2-Phenyl-5-methyloxazole-4-carboxylic Acid is a building block used to prepare oxazole transthyretin amyloidogenesis inhibitors. It is also used to synthesize inhibitors of HldE kinase as Gram-negative antivirulence drugs. Group: Biochemicals. Grades: Highly Purified. CAS No. 18735-74-5. Pack Sizes: 500mg, 5g. Molecular Formula: C11H9NO3, Molecular Weight: 203.19. US Biological Life Sciences.
Worldwide
2-Trifluoro methyl imidazole
2-Trifluoro methyl imidazole is an intermediate used to prepare sulfonamide derivatives as amyloid β prodn. inhibitors useful in treating or preventing diseases related to A β. Group: Biochemicals. Grades: Highly Purified. CAS No. 66675-22-7. Pack Sizes: 50mg, 100mg. Molecular Formula: C4H3F3N2, Molecular Weight: 136.08. US Biological Life Sciences.
Worldwide
3-Methyl-1-butanethiol
3-Methyl-1-butanethiol. Group: Biochemicals. Alternative Names: 2-Methyl-4-butanethiol; 3-Methylbutanethiol; 3-Methylbutyl Mercaptan; Isoamyl Mercaptan; Isoamyl Sulfhydrate; Isopentanethiol; Isopentyl Mercaptan; Isopentylthiol; iso-Amyl Mercaptan. Grades: Highly Purified. CAS No. 541-31-1. Pack Sizes: 1g. Molecular Formula: C5H12S, Molecular Weight: 104.21. US Biological Life Sciences.
4-[[4-[[4-(2,2,2-Trifluoroethoxy)-1,2-benzoxazol-3-yl]oxymethyl]piperidin-1-yl]methyl]oxane-4-carboxylic acid, a potent remedy for Alzheimer's disease, operates via focusing on beta-amyloid plaques, an established sign of the disease. The potential outcome of this product is to decelerate or bring to a standstill the progress of the disease, subsequently enhancing patients' quality of life. Synonyms: 4-{[4-({[4-(2,2,2-Trifluoroethoxy)-1,2-benzisoxazol-3-yl]oxy}methyl)piperidin-1-yl]methyl}-tetrahydro-2H-pyran-4-carboxylic acid; 4-{[4-({[4-(2,2,2-Trifluoroethoxy)-1,2-benzoxazol-3-yl]oxy}methyl)-1-piperidinyl]methyl}tetrahydro-2H-pyran-4-carboxylic acid; 2H-Pyran-4-carboxylic acid, tetrahydro-4-[[4-[[[4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazol-3-yl]oxy]methyl]-1-piperidinyl]methyl]-. Grades: ≥95%. CAS No. 907607-22-1. Molecular formula: C22H27F3N2O6. Mole weight: 472.45.
AA 147 is an endoplasmic reticulum (ER) proteostasis regulator. Activates the ATF6 transcriptional program independently of ER stress and/or global UPR activation. Selectively reduces secretion of amyloidogenic transthyretin (TTR) from HepG2 cells. Reduces amyloidogenic immunoglobulin light chain (ALLC) secretion from ALMC-2 cells (EC50 = 1.1 μM). Synonyms: N-(2-Hydroxy-5-methylphenyl)benzenepropanamide; N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide. Grades: ≥98%. CAS No. 393121-74-9. Molecular formula: C16H17NO2. Mole weight: 255.31.
Acetyl-(N-Me-Leu17,N-Me-Phe19)-Amyloid β-Protein (16-20) amide is a membrane-permeable inhibitor of Aβ (1-40) fibrillogenesis. Synonyms: Ac-Lys-(NMe)Leu-Val-(NMe)Phe-Phe-NH2; N2-Acetyl-L-lysyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-phenylalanyl-L-phenylalaninamide; L-Phenylalaninamide, N2-acetyl-L-lysyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-phenylalanyl-. Grades: ≥95%. CAS No. 461640-33-5. Molecular formula: C39H59N7O6. Mole weight: 721.94.
ACID BLUE 41
Acid blue 41 is a synthetic dye. It is a member of the triphenylmethane family of dyes and is known for its bright blue color. Uses: Acid blue 41 has several potential scientific research applications. one of the most promising uses is in the field of bioimaging. acid blue 41 has been shown to selectively stain mitochondria in live cells, making it a useful tool for studying mitochondrial function and dynamics. it has also been used as a fluorescent probe for detecting amyloid fibrils, which are associated with several neurodegenerative diseases. Group: Acid dyes. Alternative Names: LANAPERL BLUE B;CI 62130;ACID BLUE 41;ALIZARINE DIRECT BLUE ARA;ALIZARINE SAPPHIRE AR;10-dioxo-)-monosodiumsalt;10-dioxo-dihydro-monosodiumsalt;2-anthracenesulfonicacid,1-amino-9,10-dihydro-4-(p-(n-methylacetamido)anilino. CAS No. 2666-17-3. Molecular formula: C23H18N3NaO6S. Mole weight: 487.46. Appearance: Dark blue powder. IUPACName: sodium; 4-[4-[acetyl(methyl)amino]anilino]-1-amino-9, 10-dioxoanthracene-2-sulfonate. Canonical SMILES: CC (=O)N (C)C1=CC=C (C=C1)NC2=CC (=C (C3=C2C (=O)C4=CC=CC=C4C3=O)N)S (=O) (=O)[O-]. [Na+]. Density: 1.542 g/mL. ECNumber: 220-201-9. Catalog: ACM2666173.
α-Amyloid Precursor Protein Modulator
α-Amyloid Precursor Protein Modulator is a cell-permeable protein kinase C (PKC) activator. It was shown to induce differentiation of hESCs into Pdx-1 expressing pancreatic progenitor cells. Synonyms: TPPB; alpha-APP Modulator; (2E,4E)-N-[(2S,5S)-5-(hydroxymethyl)-1-methyl-3-oxo-2-propan-2-yl-2,4,5,6-tetrahydro-1,4-benzodiazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]penta-2,4-dienamide. Grades: >98%. CAS No. 497259-23-1. Molecular formula: C27H30F3N3O3. Mole weight: 501.55.
Amyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-glucopyranoside is an extensively employed compound in the realm of biomedicine, manifesting as an invaluable asset for the scrutiny of glycosylation mechanisms and the pioneering of groundbreaking pharmaceuticals. Synonyms: beta-D-Glucopyranoside, pentyl 2-(acetylamino)-2-deoxy-, 3,4,6-triacetate; Amyl-2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-glucopyranoside;b-D-Glucopyranoside,pentyl2-(acetylamino)-2-deoxy-,3,4,6-triacetate; [(2R,3S,4R,5R,6R)-5-acetamido-3,4-diacetyloxy-6-pentoxyoxan-2-yl]methyl acetate; [(2R,3S,4R,5R,6R)-3,4-BIS(ACETYLOXY)-5-ACETAMIDO-6-(PENTYLOXY)OXAN-2-YL]METHYL ACETATE. CAS No. 146288-30-4. Molecular formula: C19H31NO9. Mole weight: 417.45.
Amylin (14-20) (human)
The formation of amyloid deposits by IAPP can play a central role in the pathogenesis of type 2 diabetes. In addition to the amyloidogenic 20-29 region, the NFLVHSS domain (IAPP 14-20) tends to aggregate and seems to be involved in plaque formation. Synonyms: H-Asn-Phe-Leu-Val-His-Ser-Ser-OH; L-asparagyl-L-phenylalanyl-L-leucyl-L-valyl-L-histidyl-L-seryl-L-serine; (2S,5S,8S,11S,14S,17S,20S)-8-((1H-imidazol-4-yl)methyl)-20,22-diamino-17-benzyl-2,5-bis(hydroxymethyl)-14-isobutyl-11-isopropyl-4,7,10,13,16,19,22-heptaoxo-3,6,9,12,15,18-hexaazadocosan-1-oic acid. Grades: ≥95%. CAS No. 121341-77-3. Molecular formula: C36H54N10O11. Mole weight: 802.89.
Amylmetacresol. Group: Biochemicals. Alternative Names: 6-Pentyl-m-Cresol; 5-Methyl-2-pentylphenol; 6-n-Amyl-m-cresol. Grades: Highly Purified. CAS No. 1300-94-3. Pack Sizes: 1g. Molecular Formula: C12H18O, Molecular Weight: 178.27. US Biological Life Sciences.
Worldwide
Amylopectin - from maize
Amylopectin - from maize boasts its status as a paramount and environmentally sustainable byproduct obtained from maize starch. This versatile substance has been pervasively employed within the field of biomedical research due to its inherent biocompatibility and degradability. Serving as a formidable carrier for drug delivery systems and tissue engineering, its intricate composition exudes proficiency in encapsulating an array of pharmaceuticals, thus promoting precise release and optimized therapeutic effects. Synonyms: AMYLOPECTIN; 9037-22-3; (2R,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6S)-6-[[(2R,3S,4R,5R,6R)-4,5-dihydroxy-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[(2R,3S,4R,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-2-yl]methoxy]-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol; Amylopectin - from maize; Amylopectine; SCHEMBL2046142; AKOS015916501; YA39745; YA164124; Q271643; (2R,3R,4S,5S,6R)-2-{[(2R,3S,4R,5R,6R)-2-({[(2S,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}methyl)-4,5-dihydroxy-6-{[(2R,3S,4R,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy}oxan-3-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol. CAS No. 9037-22-3. Molecular formula: (C6H10O5)n xH2O. Mole weight: 828.72.
Amylostatin XG Octaacetate
Amylostatin XG Octaacetate is a protected intermediate of Amylostatin XG, an analogue of an α-glucosidase inhibitor, Acarbose. Synonyms: [1S-(1α, 4α, 5β, 6α)]-4-O-[2, 3-Di-O-acetyl-4, 6-dideoxy-4-[[4, 5, 6-tris(acetyloxy)-3-[(acetyloxy)methyl]-2-cyclohexen-1-yl]amino]-α-D-glucopyranosyl]-D-glucopyranose. CAS No. 85747-82-6. Molecular formula: C39H53NO23. Mole weight: 903.83.
AP2238
AP2238 is a inhibitor of both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. Uses: Cholinesterase inhibitors. Synonyms: AP-2238; AP 2238; AP2238; CHEMBL75121; UNII-545225E0BC; BDBM10949; DNC007569; 2H-1-Benzopyran-2-one, 6, 7-dimethoxy-3- (4- ( (methyl (phenylmethyl)amino)methyl)phenyl)-; 3-[4- (N-Benzyl-N-methylaminomethyl)phenyl]-6, 7-dimethoxy-2H-1-benzopyran-2-one. Grades: 98%. CAS No. 553681-56-4. Molecular formula: C26H25NO4. Mole weight: 415.48.
(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-676)
(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-676), a peptide substrate used to determine β-secretase activity, corresponds to the 'Swedish' Lys-Met/Asn-Leu (K670N/M671L) mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Synonyms: (Asn670,Leu671)-APP770 (667-676); H-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-OH; L-seryl-L-alpha-glutamyl-L-valyl-L-asparagyl-L-leucyl-L-alpha-aspartyl-L-alanyl-L-alpha-glutamyl-L-phenylalanyl-L-arginine; (6S,9S,12S,15S,18S,21S,24S,27S,30S)-1-amino-24-(2-amino-2-oxoethyl)-30-((S)-2-amino-3-hydroxypropanamido)-9-benzyl-12-(2-carboxyethyl)-18-(carboxymethyl)-1-imino-21-isobutyl-27-isopropyl-15-methyl-8,11,14,17,20,23,26,29-octaoxo-2,7,10,13,16,19,22,25,28-nonaazadotriacontane-6,32-dicarboxylic acid. Grades: ≥90%. CAS No. 186142-28-9. Molecular formula: C50H78N14O19. Mole weight: 1179.24.
BACE-1 Inhibitor
BACE-1 Inhibitor is a potent, selective and cell-permeable inhibitor of human β-secretase (BACE-1) binding to the active site of BACE-1. It inhibits secretion of amyloid-β (Aβ) precursor protein (APP; IC50 = 29 nM) in HEK293T cells and also suppresses formation of the Aβ peptides Aβ38, Aβ40, and Aβ42 in primary chick neurons (IC50s = 3.7, 4.7, and 4.8 nM, respectively). Synonyms: BACE-1 Inhibitor; BACE 1 Inhibitor; BACE1 Inhibitor; Beta-Secretase Inhibitor IV; β-Secretase Inhibitor IV; N1-[(1S,2R)-3-(Cyclopropylamino)-2-hydroxy-1-(phenylmethyl)propyl]-5-[methyl(methylsulfonyl)amino]-N3-[(1R)-1-phenylethyl]-1,3-benzenedicarboxamide; Axon 1125. Grades: 98%. CAS No. 797035-11-1. Molecular formula: C31H38N4O5S. Mole weight: 578.72.
CEP 1347
CEP 1347, also named KT 7515 or CHEMBL290352, an ethylthiomethyl derivative, is a potent, selective inhibitor of the cJun-amino terminal kinase pathway currently under clinical evaluation for the treatment of neurodegenerative diseases. It blocks Aβ-induced cortical neuron apoptosis (EC50 ~51 nM). Uses: Anti-alzheimer agents; amyloid-β inhibitor. Synonyms: CHEMBL290352; CEP-1347; 3,9-Bis(etsm)-K-252a; CEP1347; 156177-65-0; CEP 1347; KT7515; 3,9-Bis((ethylthio)methyl)-K-252a; KT 7515; KT-7515; GTPL8173; SCHEMBL12047710; BDBM24942; CEP1374; CEP 1374; CEP-1374; ZINC3928304; AKOS024458422; KT-1575; 170587-65-2; 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 5,16-bis((ethylthio)methyl)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9S-(9alpha,10beta,12alpha))-; CEP 1347|(9S,10R,12R)-5-16-Bis[(ethylthio)methyl]-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester; methyl (15S, 16R, 18R)-10, 23-bis[(ethylsulfanyl)methyl]-16-hydroxy-15-methyl-3-oxo-28-oxa-4, 14, 19-triazaoctacyclo[12.11.2.1^{15, 18}.0^{2, 6}.0^{7, 27}.0^{8, 13}.0^{19, 26}.0^{20, 25}]octacosa-1, 6, 8, 10, 12, 20, 22, 24, 26-nonaene-16-carboxylate. CAS No. 156177-65-0. Molecular formula: C33H33N3O5S2. Mole weight: 615.76.
Elenbecestat is a novel, potent and orally bioavailable BACE1 inhibitor for the treatment of Alzheimer's disease (AD), which demonstrates prolonged reductions in plasma beta-amyloid levels after single dosing. Synonyms: E2609; N-[3-[(4aS,5R,7aS)-2-amino-5-methyl-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]thiazin-7a-yl]-4-fluorophenyl]-5-(difluoromethyl)pyrazine-2-carboxamide. Grades: ≥98%. CAS No. 1388651-30-6. Molecular formula: C19H18F3N5O2S. Mole weight: 437.44.
(-)-Epigallocatechin Gallate (EGCG)
(-)-Epigallocatechin Gallate is a tumor-inhibiting constituent of green tea. (-)-Epigallocatechin Gallate alters the cleavage of amyloid precursor protein, decreasing production of ß-amyloid and amyloid plaques in mice. This compound has neuroprotective properties; Inhibits telomerase and DNA methyltransferase; antioxidant. Group: Biochemicals. Alternative Names: Teavigo; epi-Gallocatechin 3-O-Gallate; epi-Gallocatechin Gallate; EGCG; Epigallocatechin-3-monogallate; L-Epigallocatechin Gallate; 3-O-Galloyl-(-)-epigallocatechin; (-)-cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7- triol 3-gallate; (-)-cis-3,3',4,5,5,7-Hexahydroxy-flavane-3-gallate. Grades: Highly Purified. CAS No. 989-51-5. Pack Sizes: 100mg, 250mg, 500mg, 1g. Molecular Formula: C??H??O??, Molecular Weight: 458.37. US Biological Life Sciences.
Isoamylol is one of the several isomers of amyl alcohol and the main ingredient in the production of banana oil. Group: Biochemicals. Alternative Names: Isobutyl Carbinol; Isopentanol; NSC 1029; NSC 7905; iso-Amyl Alcohol; iso-Pentanol; Isopentyl Alcohol (8CI); 2-Methyl-4-butanol; 3-Methyl-1-butanol; 3-Methyl-butane-1-ol; 3-Methylbutyl Alcohol; Isoamyl Alcohol; 3-Methyl-1-butanol. Grades: Highly Purified. CAS No. 123-51-3. Pack Sizes: 10g. US Biological Life Sciences.
Lactoferrin (322-329) (human) is a highly amyloidogenic region of lactoferrin. Synonyms: H-Asn-Ala-Gly-Asp-Val-Ala-Phe-Val-OH; L-asparagyl-L-alanyl-glycyl-L-alpha-aspartyl-L-valyl-L-alanyl-L-phenylalanyl-L-valine; (2S,5S,8S,11S,14S)-5-benzyl-14-(2-((S)-2-((S)-2,4-diamino-4-oxobutanamido)propanamido)acetamido)-2,11-diisopropyl-8-methyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazahexadecane-1,16-dioic acid. Grades: ≥95%. CAS No. 496808-32-3. Molecular formula: C35H53N9O12. Mole weight: 791.86.
LPYFD-NH2
LPYFD-NH2, is a neuroprotective peptide that binds to Amyloid-&beta. In vitro and in vivo it protects neurons against toxic effects of Aβ (1-42), which can be used in treating Alzheimer's Disease. Synonyms: H-Leu-Pro-Tyr-Phe-Asp-NH2; (3S)-4-amino-3-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-phenylpropanoyl]amino]-4-oxobutanoic acid; ZINC98052568; AKOS024457970. CAS No. 700361-48-4. Molecular formula: C33H44N6O8. Mole weight: 652.75.
Methyl 4-O-methyl-D-glucopyranosyluronate
Methyl 4-O-methyl-D-glucopyranosyluronate is a compound, aiding in the research of neurodegenerative illnesses, like the notorious Alzheimer's malady. Esteemed for its prowess in impeding designated enzymes and diminishing beta-amyloid conglomeration, this compound astutely bestows neuroprotective advantages. Molecular formula: C8H14O7. Mole weight: 222.2.
This molecular has a favorable potency versus human β-amyloid plaque and has been radiolabeled for further evaluation in in vitro binding and in vivo PET imaging experiments. Studies led to the identification of MK-3328 as a candidate PET ligand for the clinical assessment of β-amyloid plaque load. In Aug 2009, Phase-I clinical trials in Alzheimer's disease in Belgium was on-going, but no recent reported has been published yet. Uses: Alzheimer's disease. Synonyms: MK3328; MK 3328; MK-3328; 5-fluoro-2-(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)oxazolo[5,4-b]pyridine. Grades: 98%. CAS No. 1201323-97-8. Molecular formula: C14H9FN4O. Mole weight: 268.25.
NB-360 free base
NB-360 is a potent and brain penetrable BACE-1 inhibitor. NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice, a model for amyloid pathology. NB-360 stopped accumulation of activated inflammatory cells in the brains of APP transgenic mice. Upon chronic treatment of APP transgenic mice, patches of grey hairs appeared. Group: Inhibitors. Alternative Names: NB-360; NB 360; NB360. CAS No. 1262857-73-7. Molecular formula: C21H19F4N5O2. Mole weight: 449.41. Appearance: Solid powder. Purity: >98%. IUPACName: N-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl)-5-cyano-3-methylpicolinamide. Canonical SMILES: CC1=C (C (NC2=CC=C (F)C ([C@]3 (C)CO[C@@] (C) (C (F) (F)F)C (N)=N3)=C2)=O)N=CC (C#N)=C1. Catalog: ACM1262857737.
N-(Pyridin-3-ylmethyl)ethanamine
N-(Pyridin-3-ylmethyl)ethanamine (CAS# 3000-75-7) is used as a reagent in organic synthesis, in particular, that of bis-nicotine derivatives which act as inhibitors of cholinesterases and β-amyloid aggregation. It is also used in the synthesis of [11C]EMPA which acts as a potential PET tracer for orexin 2 receptors. N-(Pyridin-3-ylmethyl)ethanamine is also a nicotinic analog. Synonyms: N-(Pyridin-3-ylmethyl)ethylamine; N-Ethyl-3-pyridinemethanamine; N-Ethyl-N-(3-pyridylmethyl)amine; N-Ethyl-N-(pyridin-3-ylmethyl)amine; N-Ethyl[(3-pyridyl)methyl]amine; N-Ethyl[(pyridin-3-yl)methyl]amine; 3-[(Ethylamino)methyl]pyridine; α-Ethylamino-3-Picoline. Grades: ≥95%. CAS No. 3000-75-7. Molecular formula: C8H12N2. Mole weight: 136.19.
oligo-1,6-glucosidase
This enzyme, like EC 3.2.1.33 (amylo-α-1,6-glucosidase), can release an α-1?6-linked glucose, whereas the shortest chain that can be released by EC 3.2.1.41 (pullulanase), EC 3.2.1.142 (limit dextrinase), and EC 3.2.1.68 (isoamylase) is maltose. It also hydrolyses isomaltulose (palatinose), isomaltotriose and panose, but has no action on glycogen or phosphorylase limit dextrin. The enzyme from intestinal mucosa is a single polypeptide chain that also catalyses the reaction of EC 3.2.1.48 (sucrose α-glucosidase). Differs from EC 3.2.1.33 (amylo-α-1,6-glucosidase) in its preference for short-chain substrates and in its not requiring the 6-glucosylated residue to be at a branch point, i.e. linked at both C-1 and C-4. Group: Enzymes. Synonyms: limit dextrinase (erroneous); isomaltase; sucrase-isomaltase; exo-ol. Enzyme Commission Number: EC 3.2.1.10. CAS No. 9032-15-9. Oligo-1,6-Glucosidase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3782; oligo-1,6-glucosidase; EC 3.2.1.10; 9032-15-9; limit dextrinase (erroneous); isomaltase; sucrase-isomaltase; exo-oligo-1,6-glucosidase; dextrin 6α-glucanohydrolase; α-limit dextrinase; dextrin 6-glucanohydrolase; oligosaccharide α-1,6-glucohydrolase; α-methylglucosidase. Cat No: EXWM-3782.
Intermediate in the preparation of trifluoro methyl diazirine, useful as a photo-induced cross-linking probe for exploring amyloid formation. Group: Biochemicals. Alternative Names: 1- [4- [ [ [ (1, 1-Dimethylethyl) dimethylsilyl] oxy] methyl] phenyl] -2, 2, 2-trifluoro-ethanone. Grades: Highly Purified. CAS No. 87736-75-2. Pack Sizes: 50mg. US Biological Life Sciences.
Worldwide
PE 154
PE 154 is a fluorescent inhibitor of both AChE and BChE with IC50 values of 280 pM and 16 nM. PE 154 targets and labels β-amyloid plaques in histochemical analysis. Synonyms: PE 154; PE154; PE-154; 4-[[[7-(Diethylamino)-2,4-dioxo-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]-benzeneacetic acid 2-(1,2,3,4-tetrahydro-9-acridinyl)hydrazide. Grades: ≥97% by HPLC. CAS No. 1192750-33-6. Molecular formula: C35H35N5O4. Mole weight: 589.68.
Phe-Phe-OMe HCl
Phe-Phe-OMe HCl has been used in the preparation of polymer nanoparticles containing hydrophobic dipeptide for inhibition of amyloid-β fibrillation. Synonyms: L-Phenylalanyl-L-phenylalanine methyl ester hydrochloride; Phe Phe OMe HCl. Grades: ≥ 98% (HPLC). CAS No. 38017-65-1. Molecular formula: C19H22N2O3HCl. Mole weight: 362.86.
Plantazolicin
Plantazolicin is a natural antibiotic produced by the gram-positive soil bacterium Bacillus velezensis FZB42 (previously Bacillus amyloliquefaciens FZB42). It is a selective bactericidal agent that is effective against Bacillus anthracis, the causative agent of anthrax. Synonyms: plantazolicin A; PZN; ((4S)-2''''-((1S,2S)-1-((3S)-2-(2'-(2-(2-(2-((S)-4-((diaminomethylene)amino)-1-(dimethylamino)butyl)thiazol-4-yl)-5-methyloxazol-4-yl)thiazol-4-yl)-5,5'-dimethyl-[2,4'-bioxazole]-4-carboxamido)-3-methylpentanamido)-2-methylbutyl)-5-methyl-4,5-dihydro-[2,4':2',4'':2'',4''':2''',4''''-quinqueoxazole]-4-carbonyl)-L-phenylalanine. Grades: ≥95%. CAS No. 1354655-37-0. Molecular formula: C63H69N17O13S2. Mole weight: 1336.47.
(S)-(-)-2-Methyl-1-butanol
(S)-(-)-2-Methyl-1-butanol. Group: Biochemicals. Alternative Names: active-Amyl Alcohol; sec-Butylcarbinol. Grades: Highly Purified. CAS No. 1565-80-6. Pack Sizes: 10g, 25g, 50g, 100g, 250g. US Biological Life Sciences.
(S)-(+)-2-methylbutyl p-[(p-methoxybenzylidene)amino]cinnamate, an active pharmaceutical intermediate, is a vital component in the pharmaceutical industry for synthesizing medications that alleviate pain and inflammation. Such disorders include osteoarthritis and arthritis, among others. Its significant role in medicinal chemistry, as a proficient synthesis intermediate, cannot be emphasized enough. Synonyms: (+)-2-METHYLBUTYL-P[(P-METHOXYBENZYLIDENE)AMINO]CINNAMATE; ACTIVE-AMYL P-ANISALAMINOCINNAMATE; ACT-AMYL P-ANISALAMINOCINNAMATE; (S)-(+)-2-METHYLBUTYL P-[(P-METHOXYBENZYLIDENE)AMINO]CINNAMATE; (+)-2-methylbutyl-4-methoxybenzilidine-4'-aminocinnamate; (+)-2-met. Grades: 95%. CAS No. 24140-30-5. Molecular formula: C22H25NO3. Mole weight: 351.44.
Semagacestat
Semagacestat is an inhibitor of the γ-secretase enzyme. γ-Secretase enzyme is pivotal in the generation of β-amyloid (A β), a neurotoxic endogenous peptide believed to be involved in the pathogenesis of Alzheimer's disease (AD). Group: Biochemicals. Alternative Names: (2S) -2-Hydroxy-3-methyl-N- [ (1S) -1-methyl-2-oxo-2- [ [ (1S) -2, 3, 4, 5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl] amino] ethyl] butanamide; LY 450139. Grades: Highly Purified. CAS No. 425386-60-3. Pack Sizes: 10mg. US Biological Life Sciences.
TAPI-2 is a broad-spectrum inhibitor of TNF-α converting enzyme (TACE; ADAM17), other ADAMs and matrix metalloproteinases (MMPs). It inhibits phorbol-12-myristate-13-acetate-induced (PMA) shedding of various cell surface proteins, such as TGF-α, β amyloid precursor protein, L-selectin, and IL-6 receptor α subunit. Synonyms: TNF Protease Inhibitor 2; N-[(2S)-1-[[(2S)-1-(2-Aminoethylamino)-1-oxopropan-2-yl]amino]-3,3-dimethyl-1-oxobutan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butanediamide. Grades: ≥95%. CAS No. 187034-31-7. Molecular formula: C19H37N5O5. Mole weight: 415.5.
TBPB
TBPB is an allosteric M1 mAChR agonist that regulates amyloid processing and produces antipsychotic-like activity in rats. Synonyms: TBPB; 634616-95-8; 1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; CHEMBL522460; 3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one; 2-Pyrrolo-1,3,2-dioxa-phospholan; GTPL3258; SCHEMBL5473311; CWPKTBMRVATCBL-UHFFFAOYSA-N; BCP13406; TBPB, >=98% (HPLC); BDBM50263887; AKOS026750197; 2-pyrrol-1-yl-1,3,2-dioxaphospholan; CS-3517; NCGC00390669-01; HY-14562; MS-26922; FT-0746315; F85081; A918055; BRD-K86989957-001-01-7; Q27088942; 1,3-Dihydro-1-[1'-[(2-methylphenyl)methyl][1,4'-bipiperidin]-4-yl]-2H-benzimidazol-2-one; 1-(1''-(2-methylbenzyl)-1,4''-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; 1-(1''-2-methylbenzyl)-1,4''-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; 1-(1a?(2-Methylbenzyl)-1,4a?bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; 1-[1-[1-(2-Methylbenzyl)piperidin-4-yl]piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one. Grades: >98%. CAS No. 634616-95-8. Molecular formula: C25H32N4O. Mole weight: 404.55.
tert-Amyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-glucopyranoside, an intriguing biomedicine compound, exhibits remarkable potential in the scientific realm. Notably, this innovative agent showcases exceptional efficacy in combatting an array of diseases by exerting its prowess against insidious bacterial and viral infections. Its distinctive molecular arrangement unleashes a targeted assault on pathogenic enzymes, effectively thwarting their growth and activity. Synonyms: tert-Amyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-b-D-glucopyranoside;TERT-AMYL 2-ACETAMIDO-3,4,6-TRI-O-ACETYL-2-DEOXY-BETA-D-GLUCOPYRANOSIDE; beta-D-Glucopyranoside, 1,1-dimethylpropyl 2-(acetylamino)-2-deoxy-, 3,4,6-triacetate; [(2R,3S,4R,5R,6S)-5-acetamido-3,4-diacetyloxy-6-(2-methylbutan-2-yloxy)oxan-2-yl]methyl acetate. CAS No. 262849-65-0. Molecular formula: C19H31NO9. Mole weight: 417.45.
Thiazole Orange NHS Ester is a fluorescent labeling reagent used in biomedical research to selectively label DNA and RNA in living cells. It has also been used to monitor the function of lysosomes and to identify amyloid-beta plaques in Alzheimer's disease. Synonyms: N-(5-carboxypentyl)-2-[(1,4-dihydro-1-methylquinolin-4-ylidene)methyl]benzothiazol-3-ium chloride N-hydroxysuccinimide ester. Molecular formula: C28H28ClN3O4S. Mole weight: 538.06.
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