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Also acts on some other alkaloids, including codeine, normorphine and ethylmorphine, but only very slowly on 7,8-saturated derivatives such as dihydromorphine and dihydrocodeine. In the reverse direction, also reduces naloxone to the 6α-hydroxy analogue. Activated by 2-mercaptoethanol. Group: Enzymes. Synonyms: naloxone reductase; reductase, naloxone. Enzyme Commission Number: EC 1.1.1.218. CAS No. 97002-71-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0123; morphine 6-dehydrogenase; EC 1.1.1.218; 97002-71-6; naloxone reductase; reductase, naloxone. Cat No: EXWM-0123.
Morphine-6-?-D-glucuronide-D3 solution
100 ?g/mL in methanol: water (1:1), ampule of 1 mL, certified reference material. Group: Certified reference materials (crms).
Precursor: Group: Biochemicals. Grades: Purified. Pack Sizes: 1mg. US Biological Life Sciences.
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Morphine (BSA), high activity
Morphine (BSA), high activity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
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Morphine-D3-3-?-D-glucuronide solution
100 ?g/mL in methanol with 0.05% NaOH, ampule of 1 mL, certified reference material. Group: Certified reference materials (crms).
Morphine-d3 hydrochloride trihydrate
analytical standard. Group: Chemical class.
Morphine-D3 solution
1.0 mg/mL in methanol, ampule of 1 mL, certified reference material. Group: Certified reference materials (crms).
Morphine-D6 solution
1.0 mg/mL in methanol, ampule of 1 mL, certified reference material. Group: Certified reference materials (crms).
Morphine monohydrate
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Morphine sulfate
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standardsbritish pharmacopoeiaeuropean pharmacopoeia (ph. eur.)pharmacopoeial standards. Alternative Names: Hydromorphone Hydrochloride Imp. C (EP) as Hemisulphate Pentahemihydrate, Morphine Hemisulphate Pentahemihydrate,Codeine Imp. B (EP), Hydrocodone Hydrogen Tartrate 2.5-Hydrate Imp. A (EP) as Hemisulphate Pentahemihydrate, Pholcodine Imp. A (EP) as Hemisulphate Pentahemihydrate, Dihydrocodeine Hydrogen Tartrate Imp. B (EP) as Hemisulphate Pentahemihydrate, Ethylmorphine Hydrochloride Imp. B (EP) as Hemisulphate Pentahemihydrate, Codeine Imp. B (EP) as Hemisulphate Pentahemihydrate.
10α-Hydroxy- β-isomorphine
A byproduct in the synthesis of 10α-Hydroxymorphine (H948720) , with pharmaceutical properties similar to that of morphine. Group: Biochemicals. Grades: Highly Purified. CAS No. 1188377-79-8. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C17H19NO4, Molecular Weight: 301.339999999999. US Biological Life Sciences.
Worldwide
10α-Hydroxymorphine
An impurity in the synthesis of morphine, with pharmaceutical properties similar to that of morphine. Group: Biochemicals. Grades: Highly Purified. CAS No. 131563-73-0. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C17H19NO4. US Biological Life Sciences.
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2-Nitromorphine
2-Nitromorphine is an intermediate in the synthesis of 3-O-(Codein-2-yl)morphine (C634500), an impurity of Codeine (C634075). Group: Biochemicals. Grades: Highly Purified. CAS No. 49751-21-5. Pack Sizes: 10mg, 25mg. Molecular Formula: C17H18N2O5. US Biological Life Sciences.
Worldwide
3-O-(Morphin-2-yl)morphine
3-O-(Morphin-2-yl)morphine. Uses: For analytical and research use. Group: Impurity standards. Catalog: APS00434. Format: Neat.
10-Oxocodeine
Intermediate in the preparation of 10-Oxo Morphine (O870010), a decomposition product of Morphine (M652290). Group: Biochemicals. Grades: Highly Purified. CAS No. 96562-82-2. Pack Sizes: 5mg, 50mg. Molecular Formula: C18H19NO4. US Biological Life Sciences.
Worldwide
10-Oxocodeine 6-Acetate
Intermediate in the preparation of 10-Oxo Morphine (O870010), a decomposition product of Morphine (M652290). Group: Biochemicals. Grades: Highly Purified. CAS No. 96562-83-3. Pack Sizes: 10mg, 100mg. Molecular Formula: C20H21NO5. US Biological Life Sciences.
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1-Deoxy-1-vinylsulfonamido-b-D-glucuronide
1-Deoxy-1-vinylsulfonamido-b-D-glucuronide, a distinctive glucuronide metabolite, plays a pivotal role in the pharmacokinetics of several drugs, notably analgesics like morphine and codeine. Its involvement in the metabolic pathway of these drugs has remarkable ramifications in the management of pain and addiction. The complex interplay of this chemical compound with drugs necessitates a thorough understanding of its mechanism of action and pharmacological significance.
2-Aminocodeine
2-Aminocodeine is an intermediate in the synthesis of 3-O-(Codein-2-yl)morphine (C634500), an impurity of Codeine (C634075). Group: Biochemicals. Grades: Highly Purified. CAS No. 51006-02-1. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C18H22N2O3. US Biological Life Sciences.
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2-BFI hydrochloride
2-BFI hydrochloride is a high affinity I2 ligand (Ki = 9.8 nM) that acts as a putative I2 agonist. 2-BFI potentiates morphine antinociception. Synonyms: 2-BFI hydrochloride; 2 BFI hydrochloride; 2BFI hydrochloride; 2-(2-Benzofuranyl)-2-imidazoline hydrochloride; 2-(1-benzofuran-2-yl)-4,5-dihydro-1H-imidazole hydrochloride. CAS No. 89196-95-2. Molecular formula: C11H10N2O.HCl. Mole weight: 222.67.
2-Ethyl-2-phenylpentanedinitrile
2-Ethyl-2-phenylpentanedinitrile is an intermediate in synthesizing rac-Glutethimide (G598150), a hypnotic sedative which was once used to treat insomnia. When taken with codeine, it has an intense euphoric effect on the subject due to the bodys increased ability to convert codeine to morphine. Group: Biochemicals. Grades: Highly Purified. CAS No. 74220-50-1. Pack Sizes: 100mg, 500mg. Molecular Formula: C13H14N2. US Biological Life Sciences.
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2-Nitrocodeine
2-Nitrocodeine is an intermediate in the synthesis of 3-O-(Codein-2-yl)morphine (C634500), an impurity of Codeine (C634075). Group: Biochemicals. Grades: Highly Purified. CAS No. 49751-22-6. Pack Sizes: 5mg, 10mg. Molecular Formula: C18H20N2O5. US Biological Life Sciences.
Worldwide
2-Phenylbutyronitrile
2-Phenylbutyronitrile is an intermediate in synthesizing rac-Glutethimide (G598150), a hypnotic sedative which was once used to treat insomnia. When taken with codeine, it has an intense euphoric effect on the subject due to the bodys increased ability to convert codeine to morphine. Group: Biochemicals. Grades: Highly Purified. CAS No. 769-68-6. Pack Sizes: 250mg, 1g. Molecular Formula: C10H11N. US Biological Life Sciences.
Autocamtide-2-related inhibitory peptide, myristoylated is a CaM kinase II inhibitor. It is an enhanced cell-permeable derivative of autocamtide-2-related inhibitory peptide. It blocks reinstatement of morphine-seeking behavior in vivo by pretreatment. Synonyms: AIP Myristoylated; Myr-AIP. Grades: >98%. CAS No. 201422-04-0. Molecular formula: C78H142N22O20. Mole weight: 1708.12.
Autocamtide-2-related inhibitory peptide, myristoylated acetate is a CaM kinase II inhibitor that blocks the reinstatement of morphine-seeking behavior in vivo by pretreatment. It is an enhanced cell-permeable derivative of autocamtide-2-related inhibitory peptide. Synonyms: AIP Myristoylated acetate; Myr-AIP acetate; N2-(1-Oxotetradecyl)-L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-arginyl-L-arginyl-L-glutaminyl-L-α-glutamyl-L-alanyl-L-valyl-L-α-aspartyl-L-alanyl-L-leucine acetate; m-AIP acetate; Myristoylated autocamtide-2-related inhibitory peptide acetate; H-Lys(myristoyl)-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH.CH3CO2H. Grades: ≥95%. Molecular formula: C80H146N22O22. Mole weight: 1768.15.
BU 224 hydrochloride
BU 224 hydrochloride is a high affinity imidazoline I2 receptor ligand (Ki = 2.1 nM). It acts as an I2 antagonist that antagonizes the effects of imidazoline ligands on morphine antinociception. Synonyms: BU 224 hydrochloride; BU224 hydrochloride; BU-224 hydrochloride; 2-(4,5-Dihydroimidazol-2-yl)quinoline hydrochloride. CAS No. 205437-64-5. Molecular formula: C12H11N3.HCl. Mole weight: 233.7.
BU 224 Hydrochloride
High affinity ligand for the imidazoline I2 binding site (Ki = 2.1 nM). Putative I2 antagonist; antagonizes the effects of imidazoline ligands on morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract. Group: Biochemicals. Alternative Names: 2-(4,5-Dihydroimidazol-2-yl)quinoline hydrochloride. Grades: Purified. CAS No. 205437-64-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Cholinesterase, Horse serum
Cholinesterase, Horse serum infers to acetylcholinesterase (AChE) and butyryl cholinesterase (BChE). AChE and BChE catalyze the hydrolysis of 6-MAM to morphine [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EC 3.1.1.8; BCHE, Horse serum. CAS No. 9001-8-5. Pack Sizes: 100 U. Product ID: HY-P2798.
codeine 3-O-demethylase
Requires Fe2+. Catalyses a step in morphine biosynthesis. The enzyme also catalyses the 3-O-demethylation of thebaine to oripavine, with lower efficiency. Group: Enzymes. Synonyms: codeine O-demethylase; CODM. Enzyme Commission Number: EC 1.14.11.32. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0650; codeine 3-O-demethylase; EC 1.14.11.32; codeine O-demethylase; CODM. Cat No: EXWM-0650.
codeinone reductase (NADPH)
Catalyses the reversible reduction of codeinone to codeine, which is a direct precursor of morphine in the opium poppy plant, Papaver somniferum. Group: Enzymes. Enzyme Commission Number: EC 1.1.1.247. CAS No. 153302-41-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0153; codeinone reductase (NADPH); EC 1.1.1.247; 153302-41-1. Cat No: EXWM-0153.
CTOP trifluoroacetate salt
CTOP is a peptide that acts as a selective antagonist of the μ-opioid receptor (IC50 = 2.8 nM). CTOP inhibits the antinociceptive effect of morphine in the tail flick test in mice (ED50 = 0.018 nmol) and reverses morphine-induced increases in locomotor activity (ED50 = 0.02 nmol). Synonyms: Phe-Cys-Tyr-Trp-Orn-Thr-Pen-Thr; D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-ornithyl-L-threonyl-3-mercapto-L-valyl-L-threoninamide-cyclic (2?7)-disulfide trifluoroacetate salt. Grades: ≥98%. Molecular formula: C50H67N11O11S2·xCF3COOH. Mole weight: 1062.3 (free base).
Dermorphin is a hepta-peptide and a natural opioid initially isolated from the skin of South American hylid frogs Phyllomedusinae. Dermorphin binds as an agonist with high potency and selectivity to mu-opioid receptors. Dermorphin is about 30-40 times more potent than Morphine. Group: Biochemicals. Alternative Names: L-Tyrosyl-D-alanyl-L-phenylalanylglycyl-L-tyrosyl-L-prolyl-L-serinamide Trifluoroacetate; Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2 TFA Salt. Grades: Highly Purified. CAS No. 78331-26-7. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
D-Glucuronic acid
D-Glucuronic acid is widely distributed in the plant and animal kingdoms. The glucuronides present in normal urine are those of phenol, cresol, and indoxyl. After the ingestion of poisons such as morphine, chloral hydrate, camphor, or turpentine, glucuronides formed with the poison or its hydroxylated derivatives appear in the urine. Synonyms: D-GlcA; D-Glucopyranuronate; D-Glucuronate. Grades: ≥98%. CAS No. 6556-12-3. Molecular formula: C6H10O7. Mole weight: 194.14.
D-Glucuronic Acid-[UL-13C6] Sodium Salt Hydrate
A labelled D-Glucuronic Acid. D-Glucuronic acid is widely distributed in the plant and animal kingdoms. D-Glucuronic acid usually occurs in paired form as a glycosidic combination with phenols, alcohols. Such glucuronides form in the liver to detoxify poisonous hydroxyl-containing substances. The glucuronides present in normal urine are those of phenol, cresol, and indoxyl. After the ingestion of poisons such as morphine, chloral hydrate, camphor, or turpentine, glucuronides formed with the poison or its hydroxylated derivatives appear in the urine. Synonyms: D-(+)-Glucuronic Acid-13C6 Sodium Salt Hydrate; Glucosiduronic Acid-13C6 Sodium Salt Hydrate; Glucuronic Acid-13C6 Sodium Salt Hydrate. Grades: 97%; 98% atom 13C. Molecular formula: [13C]6H9NaO7 xH2O. Mole weight: 222.08.
Dipyrone
Dipyrone is a non-steroidal anti-inflammatory drug that, when coadministered with morphine, potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a relatively selective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX-1 and no activity against COX-2. Dipyrone blocks PGE2-induced hyperalgesia in several models. Group: Biochemicals. Alternative Names: 1- [ (2, 3-Dihydro-1, 5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl) methylamino] methanesulfonic Acid Sodium Salt; (Antipyrinyl methyl amino) methanesulfonic Acid Sodium Salt; ARPF; Algocalmin; Algopyrin; Anador; Analgin; Analgine; Andolor; Conmel; Diprofarn; Gifaril; Lisador; Metamizol; Metamizole; Metamizole Sodium; Metamizole Sodium Salt; Metapyrin; Methamizole Sodium; Methampyrone; Methylmelubrin; Metilon; Narone; Sulpin; Sulpyrin; Sulpyrine. Grades: Highly Purified. CAS No. 68-89-3. Pack Sizes: 1g. US Biological Life Sciences.
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Glycyl-l-glutamine
Gly-Gln suppressed morphine withdrawal symptoms in rats. Gly-Gln seems to be a neurotrophic regulator of acetylcholinesterase in the mammalian sympathetic ganglion. Synonyms: glycylglutamine; Gly-gln; (S)-5-Amino-2-(2-aminoacetamido)-5-oxopentanoic acid; L-Glutamine, glycyl-; β-Endorphin (30-31) (bovine, camel, mouse, ovine). Grades: 99%. CAS No. 13115-71-4. Molecular formula: C7H13N3O4. Mole weight: 203.20.
HA-1004
HA-1004 is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein, and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 is an antagonist for calcium , that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 91742-10-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-123468.
Ibudilast
Ibudilast is a nonselective inhibitor of cyclic nucleotide phosphodiesterase (PDE) which has been marketed for treating asthma. It crosses the blood-brain barrier, is well tolerated, is active on oral administration, reduces glial activation and attenuates pain symptoms in diverse rat models of neuropathic pain. In addition, it enhances acute morphine analgesia and attenuates morphine tolerance and withdrawal. Thus ibudilast may improve opioid efficacy and is a promising therapeutic candidate for neuropathic pain. Synonyms: MN-166, MN166, MN 166, AV-411, AV 411, AV411, KC404; KC-404; KC 404; Ibudilast. Grades: >98%. CAS No. 50847-11-5. Molecular formula: C14H18N2O. Mole weight: 230.31.
JDTic dihydrochloride
JDTic dihydrochloride is a highly selective antagonist for the κ-opioid receptor with IC50 value of 0.02nM without affecting the μ- or δ-opioid receptors. It is a 4-phenylpiperidine derivative and distantly structurally related to analgesic drugs such as meperidine and ketobemidone and more closely to the mu opioid antagonist alvimopan. It is structurally distinct from other kappa antagonists such as norbinaltorphimine. It is more selective and potent for KOR activity than other KOR antagonists. It is shown to block the antinociceptive response of nicotine in the tail-flick test with a dose-dependent manner. It can also block the nicotine withdrawal signs in mice vi... it can also block the nicotine withdrawal signs in mice via effecting the expression of a cpa associated with nicotine withdrawal. it is also reported to decrease the number of somatic withdrawal signs in morphine-dependent rats. it may produce antidepressant and anxiolytic effects and may be used in the treatment of addiction to cocaine and morphine. Synonyms: JDTic (2HCl);(3R)-1,2,3,4-Tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide hydrochloride;(R)-7-hydroxy-N-((S)-1-((3R,4R)-4-(3-hydroxyphenyl)-3,4- . Grades: 95%. CAS No. 785835-79-2. Molecular formula: C28H41Cl2N3O3. Mole weight: 538.55.
[Leu5]-Enkephalin
[Leu5]-Enkephalin is an endogenous opioid agonist peptide with morphine-like activity. It inhibits electrically stimulated contractions in mouse vas deferens (IC50 = 11.4 nM). Synonyms: Leu-enkephalin; Leucine enkephalin; Leucyl-enkephalin; H-Tyr-Gly-Gly-Phe-Leu-OH; YGGFL; L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-leucine. Grades: ≥95%. CAS No. 58822-25-6. Molecular formula: C28H37N5O7. Mole weight: 555.62.
[Leu5]-Enkephalin
[Leu5]-Enkephalin is a pentapeptide with morphine like properties. [Leu5]-Enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors. Uses: Scientific research. Group: Peptides. Alternative Names: Leu-enkephalin; Leucine enkephalin; Leucyl-enkephalin. CAS No. 58822-25-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0288.
[Leu5]-Enkephalin TFA
[Leu5]-Enkephalin TFA is an endogenous opioid agonist peptide with morphine-like activity. It inhibits electrically stimulated contractions in mouse vas deferens (IC50 = 11.4 nM). Synonyms: L-Leucine, L-tyrosylglycylglycyl-L-phenylalanyl-, mono(trifluoroacetate) (salt); L-Leucine, N-[N-[N-(N-L-tyrosylglycyl)glycyl]-L-phenylalanyl]-, mono(trifluoroacetate) (salt); Acetic acid, trifluoro-, compd. with N-[N-[N-(N-L-tyrosylglycyl)glycyl]-L-phenylalanyl]-L-leucine (1:1); Leucine-enkephalin trifluoroacetate; H-Tyr-Gly-Gly-Phe-Leu-OH.TFA; YGGFL.TFA; L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-leucine trifluoroacetic acid. Grades: ≥95%. CAS No. 73563-78-7. Molecular formula: C28H37N5O7.C2HF3O2. Mole weight: 669.65.
L-Glutamic acid dimethyl ester hydrochloride
L-Glutamic Acid Dimethyl Ester is a diester analogue of L-Glutamic Acid, a non-essential amino acid. L-Glutamic Acid Dimethyl Ester has been shown to antagonize the effects of morphine sulfate. Synonyms: H-Glu(OMe)-OMe.HCl; Dimethyl L-Glutamate Hydrochloride; (S)-Dimethyl 2-Aminopentanedioate Hydrochloride. Grades: ≥ 98% (HPLC). CAS No. 23150-65-4. Molecular formula: C7H14ClNO4. Mole weight: 211.64.
L-Glutamic Acid Dimethyl Ester Hydrochloride
L-Glutamic Acid Dimethyl Ester is a diester analogue of L-Glutamic Acid, a non-essential amino acid. L-Glutamic Acid Dimethyl Ester has been shown to antagonize the effects of morphine sulfate. Group: Biochemicals. Alternative Names: Dimethyl L-Gutamate Hydrochloride; Dimethyl Glutamate Hydrochloride; Glutamic Acid Dimethyl Ester Hydrochloride; NSC 83254. Grades: Highly Purified. CAS No. 23150-65-4. Pack Sizes: 25g. US Biological Life Sciences.
Worldwide
LY 225910
LY 225910 is a selective antagonist for cholecystokinin receptor ( CCK2 receptor ), which affects the excitatory response to morphine, and leads to morphine sensitization [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 133040-77-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101352.
Acetyl Fentanyl is a mu opiod receptor agonist, binding to receptors with properties similar to morphine (M652290), a principle alkaloid of opium. Impurity in the synthesis of Fentanyl. Group: Biochemicals. Grades: Highly Purified. CAS No. 1071703-95-1. Pack Sizes: 500μg, 1mg. Molecular Formula: C22H29ClN2O, Molecular Weight: 372.93. US Biological Life Sciences.
Cholecystokinin is a peptide hormone of the gastrointestinal system responsible for stimulating the digestion of fat and protein. Cholecystokinin, previously called pancreozymin, is synthesized by I-cells in the mucosal epithelium of the small intestine and secreted in the duodenum, the first segment of the small intestine, and causes the release of digestive enzymes and bile from the pancreas and gallbladder, respectively. It also acts as a hunger suppressant. Recent evidence has suggested that it also plays a major role in inducing drug tolerance to opioids like morphine and heroin, and is partly implicated in experiences of pain hypersensitivity during opioid withdrawal. Applications: Cholecystokinin (cck) is a peptide hormone of the gastrointestinal system responsible for stimulating the digestion of fat and protein. it is used to study brain, kidney and pancreatic functioning as well as reproductive behavior and glucose tolerance. Group: Enzymes. Synonyms: Cholecystokinin, CCK, CCK-PZ; 9011-97-6; Pancreozymin. CAS No. 9011-97-6. CCK. Activity: 2-6 Crick units/mg solid. Storage: 2-8°C. Source: Porcine intestine. Species: Porcine. Cholecystokinin, CCK, CCK-PZ; 9011-97-6; Pancreozymin. Cat No: NATE-0113.
Neuropeptide FF
Neuropeptide FF, which belongs to the RF-amide family of peptides, is an endogenous antiopioid peptide and agonist at NPFF1 and NPFF2 receptors (Ki= 2.82 and 0.21 nM respectively). Neuropeptide FF has anti-opioid effects in rodent models, inhibiting morphine-induced analgesia and inducing abstinence in morphine-tolerant rats. It also inhibits acquisition of conditioned place preference to cocaine in rats when administered at doses of 10 and 20 nmol. Uses: Narcotic antagonists. Synonyms: NPFF; H-Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2; L-phenylalanyl-L-leucyl-L-phenylalanyl-L-glutaminyl-L-prolyl-L-glutaminyl-L-arginyl-L-phenylalaninamide. Grades: ≥95% by HPLC. CAS No. 99566-27-5. Molecular formula: C54H76N14O10. Mole weight: 1081.27.
Oxymorphinone
Oxymorphinone is a major metabolite of Morphine (M652290). Group: Biochemicals. Grades: Highly Purified. CAS No. 41135-98-2. Pack Sizes: 10mg, 100mg. Molecular Formula: C17H17NO4. US Biological Life Sciences.
Worldwide
Phenolphthalein b-D-glucuronide sodium salt monohydrate
Phenolphthalein b-D-glucuronide sodium salt monohydrate, a biochemical reagent employed for drug metabolism research, and analysis of glucuronidation pathways, is a pivotal tool in detecting glucuronidated metabolites of specific drugs, viz. morphine and acetaminophen. Its primary function is to expedite analysis timelines, thus facilitating research and streamlining results. Synonyms: PHEG. CAS No. 6820-54-8. Molecular formula: C26H21O10 Na. Mole weight: 516.43.
PL 017
PL 017, a morphiceptin analog, is a selective μ opioid receptor agonist (IC50= 5.5 and > 10000 nM for inhibition of 125I-FK 33,824 and 125I-DADLE binding to μ and δ sites respectively). Although the affinity of PL017 for μ-sites is lower than that of morphine, PL 017 is more potent than morphine in all in vitro studies, suggesting a difference in the way in which peptide and alkaloid activate μ-receptors. Synonyms: Tyr-Pro-MePhe-D-Pro; PL 017; PL017; PL-017. CAS No. 83397-56-2. Molecular formula: C29H37N5O5. Mole weight: 535.64.
Pseudoginsenoside F11
Pseudoginsenoside F11 (Ginsenoside A1), a component of Panax quinquefolium (American ginseng), has been demonstrated to antagonize the learning and memory deficits induced by scopolamine, morphine and methamphetamine in mice. Uses: Scientific research. Group: Natural products. Alternative Names: Ginsenoside A1. CAS No. 69884-00-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-N0541.
(R)-(+)-1-(1-Naphthyl)ethylamine hydrochloride
(R)-(+)-1-(1-Naphthyl)ethylamine hydrochloride. Grades: 97%. CAS No. 82572-04-1. Product ID: 8-04803. Molecular formula: C12H14ClN. Mole weight: 207.7. Properties: synthetic opioid analgesic 100 times more potent than morphine.
Reticuline Hydrochloride Salt
Precursor of many aporphine and morphine-type alkaloids. Group: Biochemicals. Alternative Names: (1S)-1,2,3,4-Tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methyl-7-isoquinolinol Hydrochloride; (+)-Reticuline Hydrochloride; L-(+)-Reticuline Hydrochloride; Reticulin Hydrochloride; S-(+)-Reticuline Hydrochloride; d-Reticuline Hydrochloride. Grades: Highly Purified. CAS No. 903-91-3. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
salutaridinol 7-O-acetyltransferase
The enzyme is present in the poppy, Papaver somniferum. At pH 8-9 the product, 7-O-acetylsalutaridinol, spontaneously closes the 4?5 oxide bridge by allylic elimination to form the morphine precursor thebaine. Group: Enzymes. Enzyme Commission Number: EC 2.3.1.150. CAS No. 156859-13-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2090; salutaridinol 7-O-acetyltransferase; EC 2.3.1.150; 156859-13-1. Cat No: EXWM-2090.
SB-334867
SB-334867 (SB 334867A) is an excellent,selective and blood - brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 ( pK b =7.4), 100-fold over 5-HT 2B , 5-HT 2C with pK i values of 5.4 and 5.3, respectively [1]. SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB 334867A. CAS No. 249889-64-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10895.
SB-334867 free base
SB-334867 free base (SB334867A free base) is an excellent, selective and blood - brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 ( pK b =7.4), 100-fold over 5-HT 2B , 5-HT 2C with pK i values of 5.4 and 5.3, respectively [1]. SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB334867A free base. CAS No. 792173-99-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10895A.
SB 612111
SB 612111 hydrochloride is a selective nociceptin/orphanin FQ (NOP) receptor antagonist (Ki value 0.33, 57.6, 160.5 and 2109 nM for NOP, μ-, κ- and δ-receptors respectively). It modulates the pronociceptive action of nociceptin in an acute pain model and enhances morphine action in morphine-tolerant animals and inhibits hyperalgesia in an inflammatory pain model. Synonyms: SB 612111 hydrochloride; SB612111 hydrochloride; SB-612111 hydrochloride; (5S,7S)-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-1-methyl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol hydrochloride. Grades: 99%. CAS No. 371980-98-2. Molecular formula: C24H29Cl2NO. Mole weight: 418.4.
SB 612111 hydrochloride
SB 612111 hydrochloride is a selective NOP receptor antagonist (Ki = 0.33, 57.6, 160.5 and 2109 nM for NOP, μ-, κ- and δ-receptors, respectively). SB 612111 exhibits antagonist activity at the pronociceptive action of nociceptin in an acute pain model. SB 612111 potentiates the action of morphine in morphine-tolerant animals and blocks hyperalgesia in an inflammatory pain model. Synonyms: SB 612111 hydrochloride; SB612111 hydrochloride; SB-612111 hydrochloride; 7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-ol hydrochloride. Grades: ≥97% by HPLC. CAS No. 371980-94-8. Molecular formula: C24H29Cl2NO.HCl. Mole weight: 454.86.
thebaine 6-O-demethylase
Requires Fe2+. Catalyses a step in morphine biosynthesis. The product neopinione spontaneously rearranges to the more stable codeinone. The enzyme also catalyses the 6-O-demethylation of oripavine to morphinone, with lower efficiency. Group: Enzymes. Synonyms: T6ODM. Enzyme Commission Number: EC 1.14.11.31. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0649; thebaine 6-O-demethylase; EC 1.14.11.31; T6ODM. Cat No: EXWM-0649.
YQA14
YQA14 is a high affinity dopamine D3 receptor antagonist. YQA14 is anti-opioid addiction agent. YQA14 inhibits Morphine/Cocaine-induced conditioned place preference (CPP) in animals [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1221408-42-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-116181.
ZIP
ZIP is a selective peptide inhibitor of PKM&zeta. ZIP injections can block the impairment in morphine conditioned place preference induced [1]. Uses: Scientific research. Group: Peptides. CAS No. 863987-12-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1284.
z-Pro-D-leu-oh
z-Pro-D-leu-oh. Uses: Designed for use in research and industrial production. Additional or Alternative Names: N-CARBOBENZOXY-L-PROPYL-D-LEUCINE;MORPHINE TOLERANCE PEPTIDE;Z-PRO-D-LEU-OH;Z-PRO-D-LEU;Z-PL;Z-L-PROLYL-D-LEUCINE;prolylleucine;Cbz-Pro-D-Leu-OH. Product Category: Heterocyclic Organic Compound. CAS No. 61596-47-2. Molecular formula: C19H26N2O5. Mole weight: 362.42. Product ID: ACM61596472. Alfa Chemistry ISO 9001:2015 Certified.
10-Oxo Thebaine
A potential precursor for κ-selective opiates. Group: Biochemicals. Alternative Names: (5α)-6,7,8,14-Tetradehydro-4,5-epoxy-3,6-dimethoxy-17-methyl-morphinan-10-one. Grades: Highly Purified. CAS No. 155051-98-2. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
1,2-dehydroreticulinium reductase (NADPH)
Reduces the 1,2-dehydroreticulinium ion to (R)-reticuline, which is a direct precursor of morphinan alkaloids in the poppy plant. The enzyme does not catalyse the reverse reaction to any significant extent under physiological conditions. Group: Enzymes. Synonyms: 1,2-dehydroreticulinium ion reductase. Enzyme Commission Number: EC 1.5.1.27. CAS No. 130590-58-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1509; 1,2-dehydroreticulinium reductase (NADPH); EC 1.5.1.27; 130590-58-8; 1,2-dehydroreticulinium ion reductase. Cat No: EXWM-1509.