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| Product | Description | |
|---|---|---|
| Novobiocin | Novobiocin (Albamycin) is a potent and orally active antibiotic. Novobiocin also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin shows anti-orthopoxvirus activity [1] [2] [3] [4] [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Albamycin; Cathomycin. CAS No. 303-81-1. Pack Sizes: 5 mg. Product ID: HY-B0425. |  |
| Novobiocin | Novobiocin (Albamycin) is a potent and orally active antibiotic. Novobiocin also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin shows anti-orthopoxvirus activity. Group: Inhibitors. CAS No. 303-81-1. Molecular formula: C31H36N2O11. Mole weight: 612.628. Catalog: ACM303811. |  |
| Novobiocin | Novobiocin is an aminocoumarin antibiotic isolated from a number of species of Streptomyces. Novobiocin exhibits broad spectrum Gram +ve activity and was used clinically. Novobiocin is a potent inhibitor of bacterial DNA gyrase and acts as a competitive inhibitor of the ATPase reaction catalysed by GyrB. Group: Biochemicals. Grades: Highly Purified. CAS No. 303-81-1. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| Novobiocin | Novobiocin is found to bind at a second ATP-binding site in the C-terminal domain of Hsp90, thus disrupting the interaction of both p23 and Hsp70 co-chaperones with the Hsp90 complex. (IC50=700μmol/L). Synonyms: Streptonivicin; Inamycin; Albamycin; Cathomycin; Cardelmycin; Spheromycin; Antibiotic PA-93; Novobiocina; Benzamide, N-(7-((3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-beta-L-lyxo-hexopyranosyl)oxy)-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl)-4-hydroxy-3-(3-methyl-2-butenyl)-. Grades: >95%. CAS No. 303-81-1. Molecular formula: C31H36N2O11. Mole weight: 612.62. |  |
| Novobiocin sodium | Novobiocin (Albamycin) sodium is a potent and orally active antibiotic. Novobiocin sodium also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin sodium has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin sodium shows anti-orthopoxvirus activity [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Albamycin sodium; Cathomycin sodium. CAS No. 1476-53-5. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0425A. | |
| Novobiocin sodium salt | 1g Pack Size. Group: Antibiotics, Bioactive Small Molecules. Formula: C31H35N2NaO11. CAS No. 1476-53-5. Prepack ID 51758785-1g. Molecular Weight 634.61 g/mol. See USA prepack pricing. |  |
| Novobiocin sodium salt | 5g Pack Size. Group: Antibiotics, Bioactive Small Molecules. Formula: C31H35N2NaO11. CAS No. 1476-53-5. Prepack ID 51758785-5g. Molecular Weight 634.61 g/mol. See USA prepack pricing. | |
| Novobiocin Sodium Salt | Novobiocin is an antibiotic that acts as an inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Studies show that Novobiocin is also an inhibitor of retrovirus RNA-dependent DNA-polymerase. Novobiocin is used in the production of positively supercoiled plasmid DNA. Group: Biochemicals. Alternative Names: N-[7-[[3-O-(Aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-α-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-butenyl)benzamide monosodium salt; Albamycin Sodium; Cathomycin Sodium; Cathomycin Sodium Lyovac; NSC 2382; Vulcamycin. Grades: Highly Purified. CAS No. 1476-53-5. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| novo-Glow | novo-Glow. Pack Sizes: 25 kg. Product ID: PE-0193. Category: Coating Systems Excipients. Product Keywords: Pharmaceutical Excipients; Coating Systems Excipients; novo-Glow; PE-0193. |  |
| Novokinin | Novokinin, designed based on the structure of ovokinin, is an angiotensin AT2 receptor agonist (Ki = 7.35 μM) that displays 93-fold selectivity over AT1. Novokinin exhibits vasorelaxing and hypotensive activity via activation of the IP (prostacyclin) receptor, and suppresses food intake via activation of PGE2-EP4 interaction. Synonyms: Novokinin; L-arginyl-L-prolyl-L-leucyl-L-lysyl-L-prolyl-L-tryptophan. CAS No. 358738-77-9. Molecular formula: C39H61N11O7. Mole weight: 795.98. | |
| Novokinin | Novokinin. Group: Biochemicals. Grades: Purified. CAS No. 358738-77-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Novokinin acetate | Novokinin acetate is an angiotensin AT2 receptor agonist (Ki = 7.35 μM) that displays 93-fold selectivity over AT1. Novokinin exhibits vasorelaxing and hypotensive activity via activation of the IP (prostacyclin) receptor, and suppresses food intake via activation of PGE2-EP4 interaction. Synonyms: H-Arg-Pro-Leu-Lys-Pro-Trp-OH.CH3CO2H; L-arginyl-L-prolyl-L-leucyl-L-lysyl-L-prolyl-L-tryptophan acetic acid; Acetic acid, compd. with (L-arginyl-yl-L-leucyl-yl-L-lysyl-yl-L-prolyl-yl-L-prolyl-yl)-L-Tryptophan (1:1). Grades: ≥95%. CAS No. 2803405-27-6. Molecular formula: C41H65N11O9. Mole weight: 856.02. | |
| Novolac expoxy resin | Novolac expoxy resin. Group: Polymers. |  |
| novomix ENT (Enteric Film Coating System) | novomix ENT (Enteric Film Coating System). Pack Sizes: 25 kg. Product ID: PE-0199. Category: Coating Systems Excipients. Product Keywords: Pharmaceutical Excipients; Coating Systems Excipients; novomix ENT (Enteric Film Coating System); PE-0199. | |
| novomix Gen (General Film Coating System) | novomix Gen (General Film Coating System). Pack Sizes: 25 kg. Product ID: PE-0196. Category: Coating Systems Excipients. Product Keywords: Pharmaceutical Excipients; Coating Systems Excipients; novomix Gen (General Film Coating System); PE-0196. | |
| novomix (Moisture Resistant Film Coating System) | novomix (Moisture Resistant Film Coating System). Pack Sizes: 25 kg. Product ID: PE-0197. Category: Coating Systems Excipients. Product Keywords: Pharmaceutical Excipients; Coating Systems Excipients; novomix (Moisture Resistant Film Coating System); PE-0197. | |
| novomix (Plain Film Coating System) | novomix (Plain Film Coating System). Pack Sizes: 25 kg. Product ID: PE-0194. Category: Coating Systems Excipients. Product Keywords: Pharmaceutical Excipients; Coating Systems Excipients; novomix (Plain Film Coating System); PE-0194. Appearance: Powder. | |
| novomix SP (Special Film Coating System) | novomix SP (Special Film Coating System). Product ID: PE-0198. Category: Coating Systems Excipients. Product Keywords: Pharmaceutical Excipients; Coating Systems Excipients; novomix SP (Special Film Coating System); PE-0198. | |
| novomix TR (Transparent Film Coating System) | novomix TR (Transparent Film Coating System). Product ID: PE-0195. Category: Coating Systems Excipients. Product Keywords: Pharmaceutical Excipients; Coating Systems Excipients; novomix TR (Transparent Film Coating System); PE-0195. Appearance: Powder. | |
| 11-Hydroxynovobiocin | 11-Hydroxynovobiocin is a novobiocin homolog produced by Sebekia benihana UC 5762 (NRRL 11111). It has anti-gram-negative bacteria effect, and its activity is equivalent to 30% of novobiocin. Molecular formula: C31H36N2O12. Mole weight: 628.62. | |
| 8-demethylnovobiocic acid C8-methyltransferase | The enzyme is involved in the biosynthesis of the aminocoumarin antibiotic novobiocin. Group: Enzymes. Synonyms: NovO. Enzyme Commission Number: EC 2.1.1.284. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1891; 8-demethylnovobiocic acid C8-methyltransferase; EC 2.1.1.284; NovO. Cat No: EXWM-1891. |  |
| 8-demethylnovobiocic acid synthase | The enzyme is involved in the biosynthesis of the aminocoumarin antibiotic novobiocin. Group: Enzymes. Synonyms: novL (gene name); novobiocin ligase; novobiocic acid synthetase (misleading); 8-desmethyl-novobiocic acid synthetase; 8-demethylnovobiocic acid synthetase. Enzyme Commission Number: EC 6.3.1.15. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5718; 8-demethylnovobiocic acid synthase; EC 6.3.1.15; novL (gene name); novobiocin ligase; novobiocic acid synthetase (misleading); 8-desmethyl-novobiocic acid synthetase; 8-demethylnovobiocic acid synthetase. Cat No: EXWM-5718. | |
| Dapsone (DADPS, DDS, Avlosulfon, Croysulfone, Diphenasone, Disulone, Dumitone, Eporal, NOvophone, Sulfona-Mae, Sulfadione, 4, 4-Sulfonylbis Benzene amine) | An antibacterial used in the treatment of dermatitis herpetiformis. Group: Biochemicals. Alternative Names: DADPS, DDS, Avlosulfon, Croysulfone, Diphenasone, Disulone, Dumitone, Eporal, NOvophone, Sulfona-Mae, Sulphadione, 4, 4-Sulfonylbis Benzene amine. Grades: Highly Purified. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| decarbamoylnovobiocin carbamoyltransferase | The enzyme catalyses the last step in the biosynthesis of the aminocoumarin antibiotic novobiocin. The reaction is activated by ATP. Group: Enzymes. Synonyms: novN (gene name). Enzyme Commission Number: EC 2.1.3.12. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2014; decarbamoylnovobiocin carbamoyltransferase; EC 2.1.3.12; novN (gene name). Cat No: EXWM-2014. | |
| demethyldecarbamoylnovobiocin O-methyltransferase | The enzyme is involved in the biosynthesis of the aminocoumarin antibiotic novobiocin. Group: Enzymes. Synonyms: NovP. Enzyme Commission Number: EC 2.1.1.285. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1892; demethyldecarbamoylnovobiocin O-methyltransferase; EC 2.1.1.285; NovP. Cat No: EXWM-1892. | |
| Descarbamylnovobiocin | Descarbamylnovobiocin is a derivative of novobiocin and it is a hydroxycoumarin that is novobiocin lacking the carbamoyl group from position 3 on the hexose ring. Synonyms: Novclobiocin 103. Grades: >95% by HPLC. CAS No. 75057-97-5. Molecular formula: C30H35NO10. Mole weight: 569.60. | |
| Dihydronovobiocin | Dihydronovobiocin is a derivative of novobiocin. It is active against the bacteria S. aureus, S. haemolyticus, D. pneumoniae, S. typhosa, K. pneumoniae, and P. multocida (MICs = 0.6, 2, 0.6, 10, 10, and 3 μg/ml, respectively). Dihydronovobiocin inhibits DNA gyrase subunit B with an IC50 value of 64.5 nM. Synonyms: N-[7-[[3O-(aminocarbonyl)-6-deoxy-5C-methyl-4O-methyl-α-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1benzopyran-3-yl]-4-hydroxy-3-(3-methylbutyl)-benzamide. Grades: >95% by HPLC. CAS No. 29826-16-2. Molecular formula: C31H38N2O11. Mole weight: 614.64. | |
| Repaglinide (Prandin, 2-Ethoxy-4-[2-[[ (1S) -3-methyl-1-[2- (1-piperidinyl) butyl]amino]-2-oxoethyl]-benzoic Acid, AG-EE-623, Novonorm,) | Non-sulfonylurea oral hypoglycemic agent. Used as an antidiabetic. Group: Biochemicals. Alternative Names: Prandin, 2-Ethoxy-4-[2-[[ (1S) -3-methyl-1-[2- (1-piperidinyl) butyl]amino]-2-oxoethyl]-benzoic Acid, AG-EE-623, Novonorm. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 1-Cyclopropane Mycophenolic Acid | 1-Cyclopropane Mycophenolic Acid is a non-active analogue of Mycophenolic Acid (M831500), an antibiotic produced by Penicillium brevi-compactum, P. Stoloniferum and related spp. A selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of purine nucleotides. Group: Biochemicals. Grades: Highly Purified. CAS No. 125198-40-5. Pack Sizes: 10mg, 100mg. Molecular Formula: C18H22O6. US Biological Life Sciences. | Worldwide |
| 2,4-Diamino-6-hydroxypyrimidine | 2,4-Diamino-6-hydroxypyrimidine is a specific GTP cyclohydrolase I inhibitor (the rate-limiting enzyme in de novo pterin synthesis). 2,4-Diamino-6-hydroxypyrimidine blocks Tetrahydrobiopterin (BH4) synthesis and suppresses NO production [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 56-06-4. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-100954. | |
| 2-Amino-5- (2-bromoacetyl) benzonitrile Hydrobromide | 2-Amino-5- (2-bromoacetyl) benzonitrile Hydrobromide is an intermediate in the synthesis of Cimaterol (C441600), an beta-adrenergic agonist that was shown to stimulate lipolysis in vivo and in vitro, but failed to influence rates of de novo fatty acid synthesis in either liver or white adipose tissue. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg, 250mg. Molecular Formula: C9H8Br2N2O. US Biological Life Sciences. | Worldwide |
| 3,3',5,5'-Tetraiodo-L-thyronine sodium salt | 3,3',5,5'-Tetraiodo-L-thyronine sodium saltm is the sodium salt of levothyroxine, a synthetic levoisomer of thyroxine (T4) that is similar to the endogenous hormone produced by the thyroid gland. In peripheral tissues, levothyroxine is deiodinated by 5'-deiodinase to form triiodothyronine (T3). T3 enters the cell and binds to nuclear thyroid hormone receptors, the activated hormone-receptor complex in turn triggers gene expression and produces proteins required in the regulation of cellular respiration, thermogenesis, cellular growth and differentiation, and the metabolism of proteins, carbohydrates and lipids. T3 also exhibits cardiostimulatory effects. Synonyms: L-Thyroxine NaLevothyroxine sodium; Levothyroxine sodium; L-Thyroxine sodium; Euthyrox; Unithroid; Levoxyl; eltroxin; Novothyrox; Levaxin; Letter; levothroid; Sodium levothyroxine; Sodium thyroxinate; L-Thyroxine sodium salt; Sodium L-thyroxine; synthroid; Laevoxin; Thyroxevan; Oroxine; Thyroxin sodium; sodium;(2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate. Grades: ≥ 98% (HPLC). CAS No. 25416-65-3. Molecular formula: C15H10I4NNaO4. Mole weight: 798.85. | |
| 4-Hydroxyanisole | 4-Hydroxyanisole. Group: Biochemicals. Alternative Names: 4-Methoxyphenol; p-Methoxyphenol; 1-Hydroxy-4-methoxybenzene; 4-MP; BMS 181158; HQMME; Hydroquinone Methyl Ether; Hydroquinone Monomethyl Ether; Leucobasal; Leucodine B; MEHQ; MQ-F; Mechinolum; Mequinol; NSC 4960; Novo-Dermoquinona; PMF; p-Guaiacol; p-Hydroxyanisol; p-Hydroxyanisole; p-Hydroxymethoxybenzene; p-Methoxyphenol. Grades: Highly Purified. CAS No. 150-76-5. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 4-Hydroxyanisole-d4 | 4-Hydroxyanisole-d4. Group: Biochemicals. Alternative Names: 4-Methoxyphenol-d4; p-Methoxyphenol-d4; 1-Hydroxy-4-methoxybenzene-d4; 4-MP-d4; BMS 181158-d4; HQMME-d4; Hydroquinone Methyl Ether-d4; Hydroquinone Monomethyl Ether-d4; Leucobasal; Leucodine B-d4; MEHQ-d4; MQ-F-d4; Mechinolum-d4; Mequinol-d4; NSC 4960; Novo-Dermoquinona; PMF-d4; p-Guaiacol-d4; p-Hydroxyanisol-d4; p-Hydroxyanisole-d4; p-Hydroxymethoxybenzene-d4; p-Methoxyphenol-d4. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 4-hydroxyphenylpyruvate 3-dimethylallyltransferase | The enzyme is involved in the biosynthesis of the 3-dimethylallyl-4-hydroxyphenylpyruvate moiety of the aminocoumarin antibiotics clorobiocin and novobiocin. Group: Enzymes. Synonyms: CloQ; 4HPP dimethylallyltransferase; NovQ. Enzyme Commission Number: EC 2.5.1.111. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2727; 4-hydroxyphenylpyruvate 3-dimethylallyltransferase; EC 2.5.1.111; CloQ; 4HPP dimethylallyltransferase; NovQ. Cat No: EXWM-2727. | |
| 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase | The enzyme, characterized from yeast and mammals, catalyses the hydroxylation of carbon 2 of long- or very-long-chain fatty acids attached to (4R)-4-hydroxysphinganine during de novo ceramide synthesis. The enzymes from yeast and from mammals contain an N-terminal cytochrome b5 domain that acts as the direct electron donor to the desaturase active site. The newly introduced 2-hydroxyl group has R-configuration. cf. EC 1.14.18.7, dihydroceramide fatty acyl 2-hydroxylase. Group: Enzymes. Synonyms: FA2H (gene name); SCS7 (gene name). Enzyme Commission Number: EC 1.14.18.6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0968; 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase; EC 1.14.18.6; FA2H (gene name); SCS7 (gene name). Cat No: EXWM-0968. | |
| 5-Diethylamino-2-Pentanone | Heterocyclic Organic Compound. Alternative Names: 5-(diethylamino)-2-pentanon;5-(N,N-Diethylamino)pentan-2-one;5-Diethylaminopentane-2-one;DF 493;df493;Novalketone;NOVOL KETONE;5-DIETHYLAMINO-2-PENTANONE. CAS No. 105-14-6. Molecular formula: C9H19NO. Mole weight: 157.25. Purity: technical. Density: 0.861. Catalog: ACM105146. | |
| 5-Ethynyl-2'-deoxy-cytidine (5-EdC) | 5-Ethynyl-2'-deoxy-cytidine (5-EdC) is an ethynyl-labeled deoxycytidine. It is incorporates into replicating DNA to measures de novo DNA synthesis during S-phase. Synonyms: 5-Ethynyl-2'-deoxycytidine. Grades: ≥ 99% by HPLC. Molecular formula: C11H13N3O4. Mole weight: 251.24. | |
| 5-Methyl-2'-deoxycytidine | 5-Methyl-2'-deoxycytidine in single-stranded DNA can act in cis to signal de novo DNA methylation [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: 5-Methyldeoxycytidine. CAS No. 838-07-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-W012078. | |
| 5-(Methyl-d3)-2'-Deoxy Cytidine | A labelled Cytidine analog and also an isostere of Thymidine. In single stranded DNA the compound can act in cis to signal de novo DNA methylation. Group: 2h labeled compounds. CAS No. 1160707-78-7. Molecular formula: C10H12D3N3O4. Mole weight: 244.26. Appearance: White powder. Catalog: ACM1160707787. | |
| 6-Desamino-6-(4-chlorophenyl)-sulfinyladenosine 2'3'-O-(Methylethylidene) | 6-Desamino-6-[4-chlorophenyl]-sulfinyladenosine 2'3'-O-(Methylethylidene) is an intermediate in the synthesis of Succinoadenosine, a biochemical marker of adenylosuccinase deficiency-the genetic defect of purine de novo synthesis. Molecular formula: C19H19ClN4O5S. Mole weight: 450.9. | |
| 6-Desamino-6-(4-Chlorophenyl)-thioadenosine 2',3'-O-(1-Methylethylidene) | 6-Desamino-6-(4-Chlorophenyl)-thioadenosine 2',3'-O-(1-Methylethylidene) is an intermediate in the synthesis of Succinoadenosine, a biochemical marker of adenylosuccinase deficiency-the genetic defect of purine de novo synthesis. Molecular formula: C19H19ClN4O4S. Mole weight: 434.9. | |
| 6-Mercaptopurine Monohydrate | 6-Mercaptopurine Monohydrate is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. Uses: An immunosuppressive drug used to treat leukemia. it is also used for pediatric non-hodgkin's lymphoma, polycythemia vera, and psoriatic arthritis. Synonyms: 6H-Purine-6-thione, 1,7-dihydro-, monohydrate; 6,7-dihydro-3H-purine-6-thione hydrate; 1,7-Dihydro-6H-purine-6-thione monohydrate. Grades: 98 %. CAS No. 6112-76-1. Molecular formula: C5H4N4S · H2O. Mole weight: 170.19. | |
| 6-Methylthio-IMP | 6-Methylthio-IMP is an antimetabolite that inhibits de novo purine synthesis. It exhibits an antitumor effect in vivo. Synonyms: 6-Methylthioinosine-5'-monophosphate, Triethylammonium salt; 6-Methylmercapto-9-(β-D-ribofuranosyl)purine-5'-monophosphate. Grades: ≥ 95% by HPLC. CAS No. 7021-52-5. Molecular formula: C11H15N4O7PS (free acid). Mole weight: 378.29 (free acid). | |
| 6-pyruvoyltetrahydropterin synthase | Catalyses triphosphate elimination and an intramolecular redox reaction in the presence of Mg2+. It has been identified in human liver. This enzyme is involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 (sepiapterin reductase) and EC 3.5.4.16 (GTP cyclohydrolase I). Group: Enzymes. Synonyms: 2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase; 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming). Enzyme Commission Number: EC 4.2.3.12. CAS No. 97089-82-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5132; 6-pyruvoyltetrahydropterin synthase; EC 4.2.3.12; 97089-82-2; 2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase; 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming). Cat No: EXWM-5132. | |
| 6-S-(4-Chlorophenyl)-6-thio-inosine | 6-S-(4-Chlorophenyl)-6-thio-inosine is an intermediate in the synthesis of Succinoadenosine, a biochemical marker of adenylosuccinase deficiency - the genetic defect of purine de novo synthesis. CAS No. 132089-81-7. Molecular formula: C16H15ClN4O4S. Mole weight: 394.83. | |
| 6-S-(4-Chlorophenyl)-6-thio-inosine 2',3',5'-Triacetate | 6-S-(4-Chlorophenyl)-6-thio-inosine 2',3',5'-Triacetate is an intermediate in the synthesis of Succinoadenosine, a biochemical marker of adenylosuccinase deficiency - the genetic defect of purine de novo synthesis. CAS No. 132089-80-6. Molecular formula: C22H21ClN4O7S. Mole weight: 520.94. | |
| 8'-apo-carotenoid 13,14-cleaving dioxygenase | Isolated from the bacterium Novosphingobium aromaticivorans. It is less active with 4'-apo-β-carotenal and γ-carotene. Group: Enzymes. Synonyms: NACOX1 (gene name). Enzyme Commission Number: EC 1.13.11.82. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0603; 8'-apo-carotenoid 13,14-cleaving dioxygenase; EC 1.13.11.82; NACOX1 (gene name). Cat No: EXWM-0603. | |
| Acetamidomalonic acid diethyl ester | Acetamidomalonic acid diethyl ester (CAS# 1068-90-2) is a versatile building block used for the synthesis of various pharmaceutical and biologically active compounds. It is an intermediate for the preparation of Novobiocin (N888500) analogues as potential heat shock protein 90 inhibitors. Synonyms: Diethyl acetamidomalonate. Grades: ≥ 99 % (Assay). CAS No. 1068-90-2. Molecular formula: C9H15NO5. Mole weight: 217.20. | |
| adenosylcobinamide kinase | In Salmonella typhimurium LT2, under anaerobic conditions, CobU (EC 2.7.7.62 and EC 2.7.1.156), CobT (EC 2.4.2.21), CobC (EC 3.1.3.73) and CobS (EC 2.7.8.26) catalyse reactions in the nucleotide loop assembly pathway, which convert adenosylcobinamide (AdoCbi) into adenosylcobalamin (AdoCbl). CobT and CobC are involved in 5,6-dimethylbenzimidazole activation whereby 5,6-dimethylbenzimidazole is converted to its riboside, α-ribazole. The second branch of the nucleotide loop assembly pathway is the cobinamide (Cbi) activation branch where AdoCbi or adenosylcobinamide-phosphate is converted to the activated intermediate AdoCbi-GDP by Cob U. The final step in adenosylcobalamin ...erase activity is required for both assimilation of exogenous cobinamide and for de novo synthesis of adenosylcobalamin. Group: Enzymes. Synonyms: CobU; adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; AdoCbi kinase/AdoCbi-phosphate guanylyltransferase. Enzyme Commission Number: EC 2.7.1.156. CAS No. 169592-51-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2985; adenosylcobinamide kinase; EC 2.7.1.156; 169592-51-2; CobU; adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; AdoCbi kinase/AdoCbi-phosphate guanylyltransferase. Cat No: EXWM-2985. | |
| Adesulfone Sodium | Sulfoxone sodium is an anti-leprosy drug which was introduced in Japan in 1948. Uses: Leprosy. Synonyms: [Sulfonylbis(4,1-phenyleneimino)]bis-methanesulfinic Acid Disodium Salt; [Sulfonylbis(p-phenyleneimino)]di-methanesulfinic Acid Disodium Salt; Aldapsone; Aldesulfone Sodium; 4,4'-Sulfonylbis-benzenamine Bis(sodium formaldehydesulfonylate); Diamidin; Diason; Diasone; Diasone Sodium; Diazon; Disodium Formaldehydesulfoxylate-diaminodiphenyl Sulfone; NSC 27222; Novotrone; Sodium Aldesulphone; Sodium Sulfoxone; Sulfoxone Sodium; [Sulfonylbis(p-phenyleneimino)]dimethanesulfinic Acid, Disodium Salt;144-76-3 (Sulfoxone free acid). Grades: 90%. CAS No. 144-75-2. Molecular formula: C14H14N2Na2O6S3. Mole weight: 448.45. | |
| Albuterol Sulfate | Salbutamol Sulfate is a non-selective 2-adrenergic receptor agonist (IC50=8.93 μM). Uses: Non-selective β-adrenergic agonist. Synonyms: Salbutamol sulfate; Salbutamol hemisulfate; Albuterol hemisulfate; 1,3-Benzenedimethanol, α1-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-, sulfate (2:1); (±)-Salbutamol sulfate; AccuNeb; Asmadil; Bronter; Buventol; Cetsim; Cobutolin; Dilatamol; dl-Salbutamol sulfate; Ecovent; Farcolin; Grafalin; Instavent; Libretin; Loftan; Medolin; Mozal; Novosalmol; NSC 289928; Parasma; Proventil; Respax; Salbetol; Theosal; Tobybron; Vencronyl; Ventorain; Volma. Grades: ≥98%. CAS No. 51022-70-9. Molecular formula: (C13H21NO3)2·H2O4S. Mole weight: 576.70. | |
| amidophosphoribosyltransferase | Amidophosphoribosyltransferase (ATase), also known as glutamine phosphoribosylpyrophosphate amidotransferase (GPAT), is an enzyme responsible for catalyzing the conversion of 5-phosphoribosyl-1-pyrophosphate (PRPP) into 5-phosphoribosyl-1-amine (PRA), using the ammonia group from a glutamine side-chain. This is the committing step in de novo purine synthesis. In humans it is encoded by the PPAT (phosphoribosyl pyrophosphate amidotransferase) gene. ATase is a member of the purine/pyrimidine phosphoribosyltransferase family. Group: Enzymes. Synonyms: phosphoribosyldiphosphate 5-amidotransfer. Enzyme Commission Number: EC 2.4.2.14. CAS No. 9031-82-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2641; amidophosphoribosyltransferase; EC 2.4.2.14; 9031-82-7; phosphoribosyldiphosphate 5-amidotransferase; glutamine phosphoribosyldiphosphate amidotransferase; α-5-phosphoribosyl-1-pyrophosphate amidotransferase; 5'-phosphoribosylpyrophosphate amidotransferase; 5-phosphoribosyl-1-pyrophosphate amidotransferase; 5-phosphororibosyl-1-pyrophosphate amidotransferase; glutamine 5-phosphoribosylpyrophosphate amidotransferase; glutamine ribosylpyrophosphate 5-phosphate amidotransferase; phosphoribose pyrophosphate amidotransferase; phosphoribosyl pyrophosphate amidotransfe | |
| AMPK Signaling Agonist, F17 (4-hydroxy-1-isobutyl-N-(5-methylthiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide) | A cell-permeable 4-hydroxy-2-oxo quinoline carboxamide that acts as an agonist of AMPK signaling. It is shown to reduce fat storage in C. elegans (EC50 ~0.1uM) and reduce the expression level of fat-7 (a C. elegans ortholog of mammalian stearoyl-CoA desaturase-1), through aak-1 (an ortholog for the AMPK-a1 catalytic subunit) and K08F8.2 (a transcription factor) dependent mechanisms. In addition, it markedly reduces the number of lipid droplets in HepG2 human hepatocarcinoma cells at 25uM, and elicits the phosphorylation and inactivation of acetyl coenzyme A carboxylase (ACC, the enzyme that catalyzes the rate-limiting step in de novo fatty acid synthesis). F17-induced ACC phosphorylation can be abrogated by simultaneous treatment with an AMPK inhibitor compound C. Group: Biochemicals. Grades: Highly Purified. CAS No. 280112-24-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| ATIC Dimerization Inhibitor (Ac-Arg-Ph(4-NO2)-NEt2, ATIC Inhibitor, AICAR Tfase Inhibitor, AICAR Transformylase Inhibitor, AICAR Tranformylase/Inosine Monophosphate Cyclohydrolase Dimerization Inhibitor, AMPK Signaling Activator XI) | A cell-permeable dipeptide that reversibly blocks the homodimerization of aminoimidazole carboxamide ribonucleotide transformylase/inosine nomophosphate cyclohydrolase (ATIC) and inhibits its activity (Ki = 691nM, Kd = 240nM). AITC is a bifunctional enzyme that catalyzes the last two steps of de novo purine biosynthesis. Increases the intracellular levels of AICAR leading to the activation of AMP-activated protein kinase (AMPK). Shown to reduce cell viability in a dose-dependent manner. Exhibits a longer half-life and sustained AMPK activation (~24h), compared to AICA-riboside. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| AVN-944 | AVN-944 (VX-944) is an orally available, synthetic small molecule with potential antineoplastic activity. AVN944 inhibits inosine monosphosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanosine triphosphate (GTP), a purine molecule required for DNA and RNA synthesis. AVN944 appears to have a selective effect on cancer cells in that deprivation of GTP in normal cells results in a temporary slowing of cell growth only. Synonyms: code name: AVN 944; AVN944; VX-944; VX 944; VX944. Grades: 0.98. CAS No. 297730-17-7. Molecular formula: C25H27N5O5. Mole weight: 477.51. | |
| Beclabuvir | Beclabuvir is a potent, non-nucleotide inhibitor of HCV NS5B which is currently in Phase III clinical trials for the treatment of chronic HCV infection. Beclabuvir is a thumb site 1-NS5B polymerase ligand. Beclabuvir has been shown to equally inhibit de novo and primer dependent synthesis, 5-75 fold more potently than previously studied compounds, thus resulting the most effective thumb site 1 inhibitor of genotype 1 (GT-1) NS5B polymerase. Synonyms: (4bS, 5aR)-12-cyclohexyl-N-(N, N-dimethylsulfamoyl)-3-methoxy-5a-((1R, 5S)-3-methyl-3, 8-diazabicyclo[3.2.1]octane-8-carbonyl)-4b, 5, 5a, 6-tetrahydrobenzo[3, 4]cyclopropa[5, 6]azepino[1, 2-a]indole-9-carboxamide hydrochloride; BMS791325; BMS-791325; BMS 791325. Grades: 99.87%. CAS No. 958002-33-0. Molecular formula: C36H45N5O5S. Mole weight: 659.84. | |
| Benzyl benzoate | Benzyl benzoate is used as a solubilizing agent and non-aqueous solvent in intramuscular injection, also as a solvent and plasticizer for cellulose and nitrocellulose. Benzyl benzoate is used as a topical therapeutic agent in the treatment of scabies and as a parasitic insecticide in veterinary medicine. Synonyms: Benzyl Alcohol; Benzyl Ester Benzoic Acid; Ascabin; Ascabiol; Benylate; Benzyl Benzenecarboxylate; Benzyl Phenylformate; BenzyloxyPhenyl Ketone; Colebenz; NSC 8081; Novoscabin; Peruscabin; Phenylmethyl Benzoate; Scabagen; Scabanca; Scabcare BB; Scabide; Scabiozon; Scobenol; Vanzoate; Venzonate. Grades: ≥97%. CAS No. 120-51-4. Molecular formula: C14H12O2. Mole weight: 212.24. | |
| Benzyl Benzoate 99+% (GC) | Benzyl Benzoate 99+% (GC). Group: Biochemicals. Alternative Names: Benzyl Ester Benzoic Acid; Ascabin; Ascabiol; Benylate; Benzyl Benzenecarboxylate; Benzyl Benzoate; Benzyl Phenylformate; Benzylets; BenzyloxyPhenyl Ketone; Colebenz; NSC 8081; Nicca Sunsolt LM 7EX; Novoscabin; Pelemol B66; Peruscabin; Phenylmethyl Benzoate; Scabagen; Scabanca; Scabcare BB; Scabide; Scabiozon; Scobenol; Vanzoate; Venzonate. Grades: GC. CAS No. 120-51-4. Pack Sizes: 100g, 250g, 1Kg, 2.5Kg, 5Kg. Molecular Formula: C14H12O2, Molecular Weight: 212.25. US Biological Life Sciences. | Worldwide |
| β-ketodecanoyl-[acyl-carrier-protein] synthase | This enzyme, which has been characterized from the bacterium Pseudomonas aeruginosa PAO1, catalyses the condensation of octanoyl-CoA, obtained from exogenously supplied fatty acids via β-oxidation, with malonyl-[acp], forming 3-oxodecanoyl-[acp], an intermediate of the fatty acid elongation cycle. The enzyme provides a shunt for β-oxidation degradation intermediates into de novo fatty acid biosynthesis. Group: Enzymes. Enzyme Commission Number: EC 2.3.1.207. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2152; β-ketodecanoyl-[acyl-carrier-protein] synthase; EC 2.3.1.207. Cat No: EXWM-2152. | |
| Brain natriuretic peptide (1-32) (human) | An agonist at atrial natriuretic peptide (ANP) receptor A (NRP1) which is secreted from cardiac ventricles in response to volume increase and pressure overload. It exhibits natriuretic, vasodilatory and lusitropic activity and suppresses sympathetic and renin-angiotensin-aldosterone systems in vivo, and decreases de novo collagen synthesis as well as increases MMP gene expression in vitro. Synonyms: Brain Natriuretic Peptide-32 human; BNP-32 (human); Nesiritide; H-Ser-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys(1)-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser-Gly-Leu-Gly-Cys(1)-Lys-Val-Leu-Arg-Arg-His-OH; L-seryl-L-prolyl-L-lysyl-L-methionyl-L-valyl-L-glutaminyl-glycyl-L-seryl-glycyl-L-cysteinyl-L-phenylalanyl-glycyl-L-arginyl-L-lysyl-L-methionyl-L-alpha-aspartyl-L-arginyl-L-isoleucyl-L-seryl-L-seryl-L-seryl-L-seryl-glycyl-L-leucyl-glycyl-L-cysteinyl-L-lysyl-L-valyl-L-leucyl-L-arginyl-L-arginyl-L-histidine (10->26)-disulfide. Grades: ≥99% by HPLC. CAS No. 124584-08-3. Molecular formula: C143H244N50O42S4. Mole weight: 3464.04. | |
| Brequinar | Brequinar is a synthetic quinolinecarboxylic acid analogue with antineoplastic properties. Brequinar inhibits the enzyme dihydroorotate dehydrogenase, thereby blocking de novo pyrimidine biosynthesis. This agent may also enhance the in vivo antitumor effect of antineoplastic agents such as 5-FU. Check for active clinical trials or closed clinical trials using this agent. Synonyms: DUP785; NSC 368390; 6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid; 6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid; 4-Quinolinecarboxylic acid, 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-; Biphenquinate. Grades: ≥98%. CAS No. 96187-53-0. Molecular formula: C23H15F2NO2. Mole weight: 375.37. | |
| Brequinar sodium | Brequinar sodium is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor (IC50 = ~20 nM), which causes the blockade of de novo pyrimidine nucleotide biosynthesis. Uses: Antineoplastic agents. Synonyms: Dup785; Dup 785; Dup-785; Brequinar Sodium. 6-Fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium; Dup 785. Grades: ≥99% by HPLC. CAS No. 96201-88-6. Molecular formula: C23H14F2NO2Na. Mole weight: 397.35. | |
| Calcium gluconate | Gluconate Calcium is a calcium supplement used in crop pesticide formulations and also in the treatment of too little calcium in the blood. Synonyms: Calcium D-gluconate; 2,3,4,5,6-Pentahydroxycaproic acid hemicalcium salt; D-Gluconic acid, calcium salt (2:1); Gluconic acid, calcium salt (2:1), D-; Biocal; Calcicol; Calciofon; Calcipur; Calcium D-gluconate; Calcium hexagluconate; Calglucol; Calglucon; Dragocal; Ebucin; Glucal; Glucobiogen; Kalpren; Novocal. Grades: ≥95%. CAS No. 299-28-5. Molecular formula: C12H22CaO14. Mole weight: 430.37. | |
| Camylofine | Camylofine is an antimuscarinic with both anticholinergic action as well as direct smooth muscle action. It can be used to treat the pain caused by smooth muscle spasm. Synonyms: Camylofine; Acamylophenine; Adopon; Avacan; Novospasmin; 3-methylbutyl 2-[2-(diethylamino)ethylamino]-2-phenylacetate. CAS No. 54-30-8. Molecular formula: C19H32N2O2. Mole weight: 320.477. | |
| CB30865 | CB30865 is a highly potent cytotoxic agent. The compound inhibits isolated mammalian thymidylate synthase (TS), but this inhibition is insufficient to account for its cellular toxicity. Thymidylate synthase (TS) is a critical enzyme in the de novo synthesis of thymidylate (dTTP) and has long been recognized as a target for chemotherapeutic intervention. Synonyms: CB-30865; CB 30865; CB30865; ZM 242421; ZM242421; ZM-242421. Grades: >98%. CAS No. 206275-15-2. Molecular formula: C26H22BrN5O2. Mole weight: 516.39. | |
| Cefuroxime sodium | Cefuroxime sodium is a second-generation cephalosporin antibiotic resistant to beta-lactamase. It has a broad-spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria. Uses: Anti-bacterial agents. Synonyms: Anaptivan; Biociclin; Biofurex; (6R,7R)-3-[[(Aminocarbonyl)oxy]methyl]-7-[[(2Z)-2-furanyl(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Sodium Salt; Cefurin; Duxima; Novocef; Zinacef. Grades: ≥95%. CAS No. 56238-63-2. Molecular formula: C16H15N4NaO8S. Mole weight: 446.36. | |
| CGP 53353 | CGP 53353, also called DAPH 2, highly selectively inhibits procarcinogenic protein kinase C-βII (PKCβII) ,and it is also an inhibitor of prionogenic Sup35 fibrillization (IC50 ~ 3.4 μM). It inhibits de novo Aβ42 assembly in vitro. Uses: Anti-alzheimer agents; amyloid-β inhibitor. Synonyms: CGP53353; CGP 53353; CGP-53353. 5,6-bis(4-fluoroanilino)isoindole-1,3-dione; DAPH 2; CGP-53353; 145915-60-2; DAPH-7; PKCbetaII/EGFR Inhibitor; CHEMBL7939; 5,6-Bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione; 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE; IN1137; 4,5-bis(4-Fluoroanilino)-phthalimide; CGP 53 353; CG53353; 4,5-Bis(4-fluoroanilino)phthalimide; 4,5-Bis[4-fluoroanilino]phthalimide; PKCbII/EGFR Inhibitor; AC1O8KXF; DAPH-2; MolMap_000016; C7866_SIGMA; SCHEMBL230492; GTPL5163; CTK8E9235; RONQPWQYDRPRGG-UHFFFAOYSA-N; HMS3229K07; HMS3269E05; ZINC600430; CGP53353; BDBM50040930; CGP 53353; DNC003638; MFCD00938569; AKOS015911570; CCG-206784; NCGC00159569-01; NCGC00159569-02; AK394840; HE005407; HE312152; ZB014534; DB-042814; FT-0643387; 5,6-bis(4-fluoroanilino)isoindole-1,3-dione; 5,6-Bis((4-fluorophenyl)amino)isoindoline-1,3-dione; 5,6-Bis-(4-fluoro-phenylamino)-isoindole-1,3-dione; BRD-K32292990-001-01-0; I14-37922; 5,6-bis[(4-fluorophenyl)amino]-2,3-dihydro-1H-isoindole-1,3-dione; CGP 53353|5,6-bis[(4-Fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione. CAS No. 145915-60-2. Molecular formula: C20H13F2N3O2. Mole weight: 365.34. | |
| Chlorobiocin | Chlorobiocin is produced by the strain of Streptomyces hygroscopicus DS 9751 and Novobiocin. Chlorobiocin is found to bind at a second ATP-binding site in the C-terminal domain of Hsp90, thus disrupting the dimerization of the Hsp90 complex. IC50=60 μmol/L. Synonyms: Clorobiocin; Antibiotic RP 18,631; NSC 227186. Grades: >98%. CAS No. 39868-96-7. Molecular formula: C35H37ClN2O11. Mole weight: 697.13. | |
| Coumermycin A1 | Coumemycin A1 is found to bind at a second ATP-binding site in the C-terminal domain of Hsp90, IC50 70 μmol/L. It is produced by the strain of Streptomyces rishirensis, Str. spinichromogene and Str. Spinicoumarensis. It has anti-gram positive bacteria, negative bacteria, mycobacterium (weak) activity, cross-resistance with Novobiocin. Uses: Topoisomerase ii inhibitors. Synonyms: coumermycin a1; Coumamycine; Coumamycinum; Cumamicina; Notomycin; Coumamycin; Notomycin A1; Sugordomycin D-1a; Sugordomycin; Antibiotic Bu-620. Grades: >98%. CAS No. 4434-5-3. Molecular formula: C55H59N5O20. Mole weight: 1110.09. | |
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