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| Product | Description | |
|---|---|---|
| PAF | PAF is an antimicrobial peptide found in Penicillium chrysogenum (Penicillium notatum), and has antifungal activity. Synonyms: Penicillium Antifungal protein (PAF). Grade: >98%. |  |
| PAF26 | PAF26 is a cell penetration peptide found in Screened from Synthetic Combinatorial Peptide Library. It has antifungal and antibacterial activity. Synonyms: Ac-Arg-Lys-Lys-Trp-Phe-Trp-NH2; N-acetyl-L-arginyl-L-lysyl-L-lysyl-L-tryptophyl-L-phenylalanyl-L-tryptophanamide; L-Tryptophanamide, N2-acetyl-L-arginyl-L-lysyl-L-lysyl-L-tryptophyl-L-phenylalanyl-. Grade: ≥95%. Molecular formula: C51H70N14O7. Mole weight: 991.19. | |
| PAF-AH human | recombinant, expressed in HEK 293 cells, ?95% (SDS-PAGE), ?95% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. |  |
| PAF (C16) | PAF (C16). Group: Biochemicals. Grades: Purified. CAS No. 74389-68-7. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Pafolacianine | Pafolacianine (OTL 38) is a fluorescent imaging agent made of near-infrared dye used in detecting tumor lesions during surgical procedures. Pafolacianine excites at 774 to 775?nm and emits at 794 to 796?nm [1] [2]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: OTL 38. CAS No. 1628423-76-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-139579. |  |
| PAF Receptor Antagonist, ABT-491 - CAS 189689-94-9 | The PAF Receptor Antagonist, ABT-491, also referenced under CAS 189689-94-9, controls the biological activity of PAF Receptor. This small molecule/inhibitor is primarily used for Membrane applications. Group: Fluorescence/luminescence spectroscopy. | |
| Pafuramidine | Pafuramidine (DB289) is an orally active proagent of Furamidine (HY-110137A). Pafuramidine is a potent anti-parasitic agent, can be used to research trypanosomiasis, Pneumocystis pneumonia and malaria [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DB289. CAS No. 186953-56-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14932. | |
| 2-thio-PAF | 2-thio PAF is an isosteric analog of PAF. Synonyms: 1-O-Hexadecyl-2-deoxy-2-thio-S-acetyl-sn-glyceryl-3-phosphorylcholine. Grade: ≥98%. CAS No. 96801-55-7. Molecular formula: C26H54NO6PS. Mole weight: 539.8. | |
| Anti-PAFAH1B1 antibody produced in rabbit | affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Apafant | Apafant (WEB 2086) is a potent platelet-activating factor (PAF) antagonist, inhibits PAF binding to human PAF receptors with a Ki of 9.9 nM. Apafant increases the gene expression of PAF-r, ?-globin, ?-globin, decreases the c-myb gene expression. Apafant shows a protective effect on alkyl-PAF-mediated lethalit[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: WEB 2086. CAS No. 105219-56-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-108634. | |
| Apafant | Platelet activating factor (PAF) antagonist. Group: Biochemicals. Alternative Names: 4-[3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-oxopropyl]morpholine; WEB 2086BS; WEB 2086. Grades: Highly Purified. CAS No. 105219-56-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Azelaoyl PAF | 10 mg/mL in ethanol. Group: Fluorescence/luminescence spectroscopy. | |
| Azelaoyl PAF | Azelaoyl-PAF is an alkyl phosphatidylcholine and is a component of the lipid pool within oxidized low-density lipoprotein (oxLDL) particles, which contain low molecular weight species. It is a potent PPARγ agonist which competes for the thiazolidinedione binding site. Synonyms: 1-hexadecyl-2-azelaoyl-sn-glycero-3-phosphocholine; C16-09:0 (COOH) PC; 1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine; 1-O-Hexadecyl-2-O-(9-carboxyoctanoyl)-sn-glyceryl-3-phosphocholine. Grade: >99%. CAS No. 354583-69-0. Molecular formula: C33H66NO9P. Mole weight: 651.85. | |
| Butanoyl PAF | Butanoyl PAF, a compound closely related to Azelaoyl PC (HY-134154), maintains over 10% of the agonist potency of platelet-activating factor ( PAF ). Butanoyl PAF's concentration in oxidized low-density lipoprotein surpasses that of enzymatically generated PAF by more than 100-fold [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 85405-03-4. Pack Sizes: 1 mg. Product ID: HY-W040221. | |
| Butenoyl PAF | Platelet-activating factor (PAF) is a lipid mediator that is well-known for its ability to cause platelet aggregation, inflammation, and allergic response at very low concentrations (approaching picomolar). Butenoyl PAF is a PAF receptor agonist, which is the product of the oxidative decomposition of 2-arachidonoyl phospholipids. It is 100-fold more abundant in oxidized LDL than PAF. Synonyms: Butenoyl PAF. Grade: ≥98%. CAS No. 474944-25-7. Molecular formula: C28H56NO7P. Mole weight: 549.7. | |
| C16-PAF | C16-PAF (PAF (C16)), a phospholipid mediator, is a platelet-activating factor and ligand for PAF G-protein-coupled receptor (PAFR). C16-PAF exhibits anti-apoptotic effect and inhibits caspase-dependent death by activating the PAFR. C16-PAF is a potent MAPK and MEK/ERK activator. C16-PAF induces increased vascular permeability[1][2][3][4][5]. Uses: Scientific research. Group: Natural products. Alternative Names: PAF (C16). CAS No. 74389-68-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108635. | |
| iPAF1C | iPAF1C is a potent inhibitor of polymerase-associated factor 1 complex (PAF1C). iPAF1C has anti-HIV activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 950403-60-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160267. | |
| Lyso-PAF C-16 | Lyso-PAF C-16 is a substrate of lysoplasmalogen (LysoPls)-specific phospholipase D (LysoPLD). Lyso-PAF C-16 selective acetylates with arachidonic acid [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 52691-62-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-141570. | |
| Lyso-PAF C-18 | Lyso-PAF C-18 is an intermediate for the synthesis of C18-PAF (HY-130345). It has an easily substituted "Lyso-PAF" structure and is easy to purify and has high yield. C18-PAF is a ligand for platelet-activating factor and PAF G protein-coupled receptor (PAFR) and has renovasodilator properties and antihypertensive lipid properties [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 74430-89-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-141581. | |
| Monoclonal Anti-PAFAH1B1 antibody produced in mouse | clone 2C12, purified immunoglobulin, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| 1-alkylglycerophosphocholine O-acetyltransferase | This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. This enzyme participates in ether lipid metabolism. Group: Enzymes. Synonyms: acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine 2-O-acetyltransferase; acetyl-CoA:lyso-PAF acetyltransferase; 1-alkyl-2-lysolecithin acetyltransferase; acyl-CoA:1-alkyl-sn-glycero-3-phosphoc. Enzyme Commission Number: EC 2.3.1.67. CAS No. 76773-96-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2247; 1-alkylglycerophosphocholine O-acetyltransferase; EC 2.3.1.67; 76773-96-1; acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine 2-O-acetyltransferase; acetyl-CoA:lyso-PAF acetyltransferase; 1-alkyl-2-lysolecithin acetyltransferase; acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acyltransferase; blood platelet-activating factor acetyltransferase; lyso-GPC:acetyl CoA acetyltransferase; lyso-platelet activating factor:acetyl-CoA acetyltransferase; lysoPAF:acetyl CoA acetyltransferase; PAF acetyltransferase; platelet-activating factor acylhydrolase; platelet-activating factor-synthesizing enzyme; 1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase; lyso-platelet-activating factor:acetyl-CoA acetyltransferase. Cat No: EXWM-2247. |  |
| 1-Linoleoyl glycerol | Platelet-activating factor (PAF) is a biologically active phospholipid synthesized by a variety of stimulated cells that acts as a mediator of platelet aggregation, inflammation, and allergy. 1-Linoleyl glyceride acts as a free-living amoeba control agent, also a biomarker of metabolic responses to hepatotoxicants and carcinogens. Synonyms: 1-LG; Glycerol 1-monolinolate; 1-Monolinolein; Glyceryl linoleate. Grade: ≥90%. CAS No. 2277-28-3. Molecular formula: C21H38O4. Mole weight: 354.5. | |
| 1-O-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine | 1-O-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PAF acether, Hag-PC, APRL, Hexadecyl-paf-acether, Platelet activating factor, AcGEPC, C16-PAF acether, HAGPC, HD-PAF, C16-PAF, Platelet-activating factor, Platelet-activating factor C16, P4904_SIGMA, P7568_SIGMA, P9525_SIGMA, Platelet Activating Factor-16, C26H54NO7P, PAF(C16), Blood platelet-activating factor, PAF (C16). Product Category: Heterocyclic Organic Compound. CAS No. 74389-68-7. Molecular formula: C26H54NO7P. Mole weight: 523.68. Purity: 0.96. IUPACName: [(2R)-2-acetyloxy-3-hexadecoxypropyl] 2-(trimethylazaniumyl)ethyl phosphate. Product ID: ACM74389687. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 1-O-Hexadecyl-2-acetyl-sn-glycero-3-phospho-(N,N,N-trimethyl)-hexanolamine | 1-O-Hexadecyl-2-acetyl-sn-glycero-3-phospho-(N,N,N-trimethyl)-hexanolamine is a PAF antagonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 99103-16-9. Pack Sizes: 5mg, 10mg. Molecular Formula: C32H66NO7P, Molecular Weight: 607.84. US Biological Life Sciences. | Worldwide |
| 1-O-Hexadecyl-2-O-acetyl-sn-glycero-3-phosphocholine | 1-O-Hexadecyl-2-O-acetyl-sn-glycero-3-phosphocholine. Group: Biochemicals. Alternative Names: PAF (C16); Platelet activating factor (c16). Grades: Highly Purified. CAS No. 65154-06-5. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. US Biological Life Sciences. | Worldwide |
| 1-O-Hexadecyl-2-O-methyl-rac-glycero-3-phosphocholine | 1-O-Hexadecyl-2-O-methyl-rac-glycero-3-phosphocholine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4-hydroxy-7-methoxy-n,n,n-trimethyl-3,5,9-trioxa-4-phosphapentacosan-1-aminium 4-oxide, 1-O-Palmityl-2-O-methyl-rac-glycero-3-phosphocholine, 2-O-Methyl PAF, AC1L1BCH, AC1Q6SMW, 85405-05-6, CBiol_001797, BSPBio_001375, KBioGR_000095, KBioSS_000095, P6034_SIGMA, CTK8F4495, KBio2_000095, KBio2_002663, KBio2_005231, KBio3_000189, KBio3_000190, Bio1_000083, Bio1_000572, Bio1_001061. Product Category: Heterocyclic Organic Compound. CAS No. 85405-05-6. Molecular formula: C25H54NO6P. Mole weight: 495.67. Purity: 0.96. IUPACName: 2-[(3-hexadecoxy-2-methoxypropoxy)-hydroxyphosphoryl]oxyethyl-trimethylazanium. Canonical SMILES: CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])OCC[N+](C)(C)C)OC. Product ID: ACM85405056. Alfa Chemistry ISO 9001:2015 Certified. | |
| 1-O-Octadecyl-2-O-benzyl-rac-glycerol | 1-O-Octadecyl-2-O-benzyl-rac-glycerol is used in the synthesis of alkylphospholipids containing modifications of the phosphocholine moiety with antitumor activities. It is also used to prepare platelet activating factor (PAF) antagonists with modified phosphorylcholine moieties. Group: Biochemicals. Grades: Highly Purified. CAS No. 86008-21-1. Pack Sizes: 500mg, 1g. Molecular Formula: C28H50O3, Molecular Weight: 434.69. US Biological Life Sciences. | Worldwide |
| 1-O-Octadecyl-2-O-benzyl-rac-glycerol-d5 | 1-O-Octadecyl-2-O-benzyl-rac-glycerol-d5 is labelled 1-O-Octadecyl-2-O-benzyl-rac-glycerol which is used in the synthesis of alkylphospholipids containing modifications of the phosphocholine moiety with antitumor activities. It is also used to prepare platelet activating factor (PAF) antagonists with modified phosphorylcholine moieties. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C28H45D5O3, Molecular Weight: 439.73. US Biological Life Sciences. | Worldwide |
| 1-O-Palmityl-rac-glycero-3-phosphocholine | 1-O-Palmityl-rac-glycero-3-phosphocholine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: rac-Lyso-platelet activating factor, 1-O-Palmityl-rac-glycero-3-phosphocholine, 52691-62-0, Lyso-PAF C-16, C13903, AC1L1H5H, CTK6E0118, AG-K-36952, 1-O-Hexadecyl-lyso-sn-glycero-3-phosphocholine, DL-|A-Lysophosphatidylcholine, |A-O-hexadecyl, H-1814, H-1815, H-1818, L-alpha-LYSOPHOSPHATIDYL-CHOLINE-gamma-O-HEXADECYL, (3-hexadecoxy-2-hydroxypropyl) 2-(trimethylazaniumyl)ethyl phosphate, 3-(hexadecyloxy)-2-hydroxypropyl 2-(trimethylammonio)ethyl phosphate, 17364-21-5. Product Category: Heterocyclic Organic Compound. CAS No. 17364-21-5. Molecular formula: C24H53NO6P. Mole weight: 482.6545. Purity: 0.96. IUPACName: (3-hexadecoxy-2-hydroxypropyl) 2-(trimethylazaniumyl)ethyl phosphate. Canonical SMILES: CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])OCC[N+](C)(C)C)O. Product ID: ACM17364215. Alfa Chemistry ISO 9001:2015 Certified. | |
| 2-Amino-3- (2-chlorobenzoyl) -5- (2-carbomethoxyethyl) thiophene | Intermediate in the preparation of platelet-activating factor (PAF) antagonists. Group: Biochemicals. Alternative Names: 5-Amino-4-(2-chlorobenzoyl)-2-thiophenepropanoic Acid Methyl Ester. Grades: Highly Purified. CAS No. 100827-77-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 2-Bromoacetylamino-3- (2-chlorobenzoyl) -5- (2-carbomethoxyethyl) thiophene | Intermediate in the preparation of platelet-activating factor (PAF) antagonists. Group: Biochemicals. Alternative Names: 5-[(2-Bromoacetyl)amino]-4-(2-chlorobenzoyl)-2-thiophenepropanoic Acid Methyl Ester; 5-[(Bromoacetyl)amino]-4-(2-chlorobenzoyl)-2-thiophenepropanoic Acid Methyl Ester. Grades: Highly Purified. CAS No. 100827-79-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-2-propyn-1-ol | Platelet-activating factor (PAF) antagonist and an intermediate in the preparation of antiarrhythmics. Group: Biochemicals. Grades: Highly Purified. CAS No. 132464-59-6. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| 3,5,9-Trioxa-4-phosphaheptacosan-1-aminium,4-hydroxy-7-methoxy-N,N,N-trimethyl-,inner salt,4-oxide | 3,5,9-Trioxa-4-phosphaheptacosan-1-aminium,4-hydroxy-7-methoxy-N,N,N-trimethyl-,inner salt,4-oxide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ET-18-OCH3;EDELFOSINE;18:0-1:0 DIETHER PC;1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINE;1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE;1-O-OCTADECYL-2-O-METHYL-SN-GLYCERYL-3-PHOSPHORYLCHOLINE;2-O-METHYL PAF C-18;SN-ET-18-OCH3. Product Category: Heterocyclic Organic Compound. Appearance: waxy solid. CAS No. 70641-51-9. Molecular formula: C27H58NO6P. Mole weight: 523.7263. Purity: 0.96. IUPACName: (2-methoxy-3-octadecoxypropyl) 2-(trimethylazaniumyl)ethyl phosphate. Product ID: ACM70641519. Alfa Chemistry ISO 9001:2015 Certified. Categories: 77286-66-9. | |
| 4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-2-propanoic Acid | Intermediate in the preparation of platelet-activating factor (PAF) antagonists. Group: Biochemicals. Alternative Names: 2-[4-(2-Chlorophenyl)-9-methyl-6H-thieno-[3,2-f][1,2,4]-triazolo[4,3-a][1,4]diazepin-2-yl]ethane-1-carboxylic Acid; Desbromo Brotizolam 2-Propanoic Acid. Grades: Highly Purified. CAS No. 100826-98-0. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| 5,6-Dehydro-N-methyl Desloratadine | 5,6-Dehydro-N-methyl Desloratadine is one of Loratadine derivatives. Loratadine is a nonsedating-type histamine H1-receptor antagonist used to treat allergies. Uses: A derivative of loratadine as dual antagonist of platelet activating factor (paf) and histamine. Synonyms: 8-chloro-11-(1-methyl-4-piperidinylidene)-11H-benzo[5,6]cyclohepta[1,2-b]pyridine; Loratadine Impurity 32. Grade: ≥95%. CAS No. 117811-18-4. Molecular formula: C20H19ClN2. Mole weight: 322.83. | |
| 7-(2-Carbomethoxyethyl)-5-(2-chlorophenyl)-thieno-1,4-diazepin-2-one | Intermediate in the preparation of platelet-activating factor (PAF) antagonists. Group: Biochemicals. Alternative Names: 5-(2-Chlorophenyl)-2,3-dihydro-2-oxo-1H-thieno[2,3-e]-1,4-diazepine-7-propanoic Acid Methyl Ester. Grades: Highly Purified. CAS No. 100827-80-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| ABT-491 | ABT-491, an imidazopyridine derivative, has been found to be a PAF receptor antagonist that was once studied against allergic rhinitis. Synonyms: ABT-491 free base; ABT-491; ABT491; ABT 491; UNII-AYB44L739V; CHEMBL369225; ABT 491; 4-ethynyl-3-[3-fluoro-4-[(2-methylimidazo[4,5-c]pyridin-1-yl)methyl]benzoyl]-N,N-dimethylindole-1-carboxamide. Grade: 98%. CAS No. 170499-15-7. Molecular formula: C28H22FN5O2. Mole weight: 479.52. | |
| ABT-491 Hydrochloride | ABT-491 Hydrochloride is a potent, selective and orally active platelet-activating factor receptor (PAF-R) antagonist (Ki = 0.6 nM in human platelets). Synonyms: 4-ethynyl-3-[3-fluoro-4-[(2-methylimidazo[4,5-c]pyridin-1-yl)methyl]benzoyl]-N,N-dimethylindole-1-carboxamide; hydrochloride; ABT 491 hydrochloride; ABT 491; ABT-491; ABT491. Grade: >98%. CAS No. 189689-94-9. Molecular formula: C28H23ClFN5O2. Mole weight: 515.97. | |
| Aglafoline | Aglafoline, isolated from Aglaia elliptifolia Merr, is a selective PAF-induced platelet aggregation inhibitor. And studies have shown that because aglafoline blocked the high-K+-induced contraction of rat thoracic aorta, it may also possess Ca+- channel b. Synonyms: methyl (1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxylate Aglafoline Methyl rocaglate AGLAFOLIN CHEBI:65374 CMLDBU00002646 143901-35-3 methyl (1R,2R,3S,3aR,8bS)-1,8b-dihydr. CAS No. 143901-35-3. Molecular formula: C28H28O8. Mole weight: 492.52. | |
| α-Bulnesene | α-Bulnesene is a novel PAF receptor antagonist with the IC 50 of 17.62 μM. α-Bulnesene can be isolated from Pogostemon cablin. α-Bulnesene shows inhibitory effect on platelet-activating factor and arachidonic acid induced rabbit platelet aggregation [1]. Uses: Scientific research. Group: Natural products. CAS No. 3691-11-0. Pack Sizes: 1 mg. Product ID: HY-N12995. | |
| (-)-AS 115 | (-)-AS 115, an isomer of AS 115, is a potent and selective inactivator of KIAA1363. KIAA1363 is an enzyme that catalyzes the hydrolysis of the 2-acetyl MAGE to MAGE and serves as a central enzyme in the PAF and LPA signaling network. Synonyms: (-)-AS 115; CHEMBL2069333; ()-AS 115; 2-Fluorophenyl-(2-(((1R,2S)-2-(butoxymethyl)cyclohexyl)methoxy)ethyl)carbamate; AS 115; AS115; BDBM50390508. Grade: ≥98%. CAS No. 926657-43-4. Molecular formula: C21H32FNO4. Mole weight: 381.5. | |
| Bioactive Lipid Compound Library | A unique collection of 385 bioactive lipids related compounds for high throughput screening (HTS) and high content screening (HCS), including Agonists & Antagonists, Endocannabinoids, Farnesyl/geranylgeranyl derivates, HETEs deHETEs, hepoxilins, Polyunsaturated fatty acids, Leukotrienes, lipoxins, LPA & phosphatidic acids, Octadecanoids, PAFs, Prostaglandins & thromboxanes, Retinoids, vitamin D metabolites, Sphingolipids, etc. ; - Targets include GPCR, HDAC, PPAR, DNA Alkylating, EGFR, etc. ; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L7000. Categories: Bioactive Lipid Compounds Libraries. |  |
| Blood platelet-activating factor | Blood platelet-activating factor. Synonyms: Blood platelet activating factor-acether; Platelet activating factor-acether; Platelet-activating factor; PAF-acether; AGEPC; Antihypertensive polar renomedullary lipid; 1-O-Alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine; PAF. Grade: 95%. CAS No. 65154-06-5. | |
| CMI-392 | CMI-392 is a dual antagonist of 5-lipoxygenese (IC50= 100 nM) and platelet-activating factor (PAF) receptor (IC50= 10 nM). Uses: Lipoxygenase inhibitors. Synonyms: 3-[[2-[2-(4-chlorophenyl)sulfanylethoxy]-3-methoxy-5-[(2S,5S)-5-(3,4,5-trimethoxyphenyl)oxolan-2-yl]phenyl]methyl]-1-hydroxy-1-methylurea; 2-(3-methoxy-4-(4-chlorophenylthioethoxy)-5-(N-methyl-N-hydroxyureidyl)methylphenyl)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran; CMI 392; CMI-392. CAS No. 205654-37-1. Molecular formula: C31H37ClN2O8S. Mole weight: 633.15. | |
| CP-96021 hydrochloride | CP-96021 hydrochloride is a potent, balanced, combined and orally active antagonist of leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor with Kis of 34 and 37 nM, respectively. Synonyms: (E)-5-Fluoro-2-(3-((4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenoxy)methyl)styryl)benzo[d]thiazole hydrochloride; 1-[4-({3-[(E)-2-(5-Fluoro-1,3-benzothiazol-2-yl)vinyl]benzyl}oxy)phenyl]-2-methyl-1H-imidazo[4,5-c]pyridine hydrochloride (1:1); Benzothiazole, 5-fluoro-2-[(E)-2-[3-[[4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenoxy]methyl]phenyl]ethenyl]-, hydrochloride (1:1). Grade: ≥95%. CAS No. 167011-22-5. Molecular formula: C29H22ClFN4OS. Mole weight: 529.03. | |
| CP-96486 | CP-96486 is a potent and orally active antagonist of leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor, with Kis of 20 and 24 nM, respectively. Synonyms: Quinoline, 7-chloro-2-[(1E)-2-[3-[[4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenoxy]methyl]phenyl]ethenyl]-; (E)-7-Chloro-2-[2-[3-[[4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenoxy]methyl]phenyl]ethenyl]quinoline; 7-Chloro-2-[(1E)-2-[3-[[4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenoxy]methyl]phenyl]ethenyl]quinoline. Grade: ≥95%. CAS No. 139401-45-9. Molecular formula: C31H23ClN4O. Mole weight: 502.99. | |
| CV-6209 | Competitive PAF receptor antagonist. Inhibits PAF induced human platelet aggregation. Inhibits PAF induced hypotension and lethality. Group: Biochemicals. Alternative Names: 2-(2-Acetyl-6-methoxy-3,9-dioxo-4,8-dioxa-2,10-diazaoctacos-1-yl)-1-ethyl-pyridinium Chloride. Grades: Highly Purified. CAS No. 100488-87-7. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| CV-6209 chloride | CV-6209 is a potent platelet-activating factor (PAF) receptor antagonist, which inhibits aggregation of rabbit and human platelets induced by PAF with IC50 values of 75 and 170 nM, respectively. It has little effect on platelet aggregation induced by arachidonic acid, ADP, or collagen. CV-6209 is used to study the role of PAF receptor signaling in vitro and in vivo. Synonyms: 2-(2-acetyl-6-methoxy-3,9-dioxo-4,8-dioxa-2,10-diazaoctacos-1-yl)-1-ethyl-pyridinium monochloride. Grade: ≥95%. CAS No. 100488-87-7. Molecular formula: C34H60N3O6·Cl. Mole weight: 642.3. | |
| CV-6209-d5 | CV-6209-d5 is used as an internal standard for the quantification of CV-6209 by GC- or LC-mass spectrometry. CV-6209 is a potent platelet-activating factor (PAF) receptor antagonist, which inhibits aggregation of rabbit and human platelets induced by PAF with IC50 values of 75 and 170 nM, respectively. It has little effect on platelet aggregation induced by arachidonic acid, ADP, or collagen. CV-6209 is used to study the role of PAF receptor signaling in vitro and in vivo. Grade: ≥99% atom D. Molecular formula: C34H55D5N3O6·Cl. Mole weight: 647.4. | |
| Cyclohexylamine | Cyclohexylamine appears as a clear colorless to yellow liquid with an odor of ammonia. Flash point 90°F. Irritates the eyes and respiratory system. Skin contact may cause burns. Less dense than water. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion.;Liquid; PelletsLargeCrystals, Liquid;Liquid;COLOURLESS-TO-YELLOW LIQUID WITH PUNGENT ODOUR.;Colorless to yellow liquid with an odor of ammonia.;Colorless or yellow liquid with a strong, fishy, amine-like odor. Group: Polymers. Product ID: cyclohexanamine. Molecular formula: 99.17g/mol. Mole weight: C6H11NH2;C6H13N;C6H13N. C1CCC(CC1)N. InChI=1S / C6H13N / c7-6-4-2-1-3-5-6 / h6H, 1-5, 7H2. PAFZNILMFXTMIY-UHFFFAOYSA-N. |  |
| Edelfosine | Edelfosine, an orally administered antileishmanial drug, has anti-metastasis effect in experimental tumors. Edelfosine is a synthetic lysophospholipid analogue that acts as an inhibitor of phosphatidylinositol phospholipase C (IC50 = 9.6 μM in fibroblasts and adenocarcinoma cells) and an agonist at platelet-activating factor (PAF) receptors. Uses: Phosphodiesterase inhibitors. Synonyms: ALP; 3,5,9-Trioxa-4-phosphaheptacosan-1-aminium, 4-hydroxy-7-methoxy-N,N,N-trimethyl-, inner salt, 4-oxide; 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine; ET-18-OMe; ET 18-OCH3; rac-1-Octadecyl-2-methoxyglycero-3-phosphocholine; NSC-324368; (±)-4-Hydroxy-7-methoxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphaheptacosan-1-aminium hydroxide inner salt 4-oxide. Grade: ≥95%. CAS No. 70641-51-9. Molecular formula: C27H58NO6P. Mole weight: 523.73. | |
| fusicocca-2,10(14)-diene synthase | A multifunctional enzyme with EC 2.5.1.29 farnesyltranstransferase activity. Group: Enzymes. Synonyms: fusicoccadiene synthase; PaFS; PaDC4. Enzyme Commission Number: EC 4.2.3.43. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5202; fusicocca-2,10(14)-diene synthase; EC 4.2.3.43; fusicoccadiene synthase; PaFS; PaDC4. Cat No: EXWM-5202. | |
| Ginkgolide A | Family of bioactive terpenes treating cardiovascular and cerebrovascular diseases. Specific platelet activating factor (PAF) antagonists. Group: Biochemicals. Alternative Names: (1R, 3S, 3aS, 4R, 6aR, 7aR, 7bR, 8S, 10aS, 11aS) -3- (1, 1-Dimethylethyl) hexahydro-4, 7b-dihydroxy-8-methyl-9H-1, 7a- (epoxymethano) -1H, 6aH-cyclopenta[c]furo[2, 3-b]furo[3', 2': 3, 4]cyclopenta[1, 2-d]furan-5, 9, 12 (4H) -trione; BN 52020. Grades: Highly Purified. CAS No. 15291-75-5. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Ginkgolide B | Family of bioactive terpenes treating cardiovascular and cerebrovascular diseases. Specific platelet activating factor (PAF) antagonists. Group: Biochemicals. Alternative Names: (1R, 3S, 3aS, 4R, 6aR, 7aR, 7bR, 8S, 10aS, 11R, 11aR) -3- (1, 1-Dimethylethyl) hexahydro-4, 7b, 11-trihydroxy-8-methyl-9H-1, 7a- (epoxymethano) -1H, 6aH-cyclopenta[c]furo[2, 3-b]furo[3', 2': 3, 4]cyclopenta[1, 2-d]furan-5, 9, 12 (4H) -trione; BN 52021. Grades: Highly Purified. CAS No. 15291-77-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Ginkgolide B | Ginkgolide B is a PAFR antagonist with an IC50 of 3.6 μM. Ginkgolide B is a bioactive diterpenoid trilactone derived from Ginkgo biloba leaves, known for its potent platelet-activating factor (PAF) antagonism. It has a complex structure with multiple chiral centers and exhibits significant neuroprotective and cerebrovascular benefits. These properties make it a promising candidate for treating neurodegenerative diseases, inflammation, and conditions related to cerebral blood flow. Uses: Fibrinolytic agents. Synonyms: (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-3-(1,1-Dimethylethyl)hexahydro-4,7b,11-trihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione; 5H-Dicyclopenta[b,c]furan-3,5a(6H)-diacetic acid, 6-tert-butyl-3a-carboxyhexahydro-α5a,1,2,3,5,8-hexahydroxy-α3-methyl-, tri-γ-lactone; Ginkgolide A, 1-hydroxy-, (1β)-; 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-4,7b,11-trihydroxy-8-methyl-, [1R-(1α,3β,3aS*,4β,6aα,7aα,7bα,8α,10aα,11β,11aR*)]-; Bilobalide B; BN 52021; BN 52051; Ginkgolides, ginkgolide B. Grade: >98%. CAS No. 15291-77-7. Molecular formula: C20H24O10. Mole weight: 424.40. | |
| Ginkgolide C | Family of bioactive terpenes treating cardiovascular and cerebrovascular diseases. Specific platelet activating factor (PAF) antagonists. Group: Biochemicals. Alternative Names: (1S, 2R, 3S, 3aS, 4R, 6aR, 7aR, 7bR, 8S, 10aS, 11R, 11aR) -3- (1, 1-Dimethylethyl) hexahydro-2, 4, 7b, 11-tetrahydroxy-8-methyl-9H-1, 7a- (epoxymethano) -1H, 6aH-cyclopenta[c]furo[2, 3-b]furo[3', 2': 3, 4]cyclopenta[1, 2-d]furan-5, 9, 12 (4H) -trione; BN 52022. Grades: Highly Purified. CAS No. 15291-76-6. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| Ginkgolide C | Ginkgolide C is a bioactive diterpenoid trilactone compound derived from the leaves of the Ginkgo biloba tree. Similar to its counterparts Ginkgolide A and Ginkgolide B, it is characterized by its unique trilactone structure with multiple chiral centers, contributing to its diverse pharmacological properties. Ginkgolide C is known for its potent antagonistic effects on platelet-activating factor (PAF), making it a promising candidate for treating inflammatory and allergic conditions. Additionally, it has been studied for its neuroprotective effects, particularly in the context of neurodegenerative diseases and cerebral ischemia. Synonyms: (1S,2R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-3-(1,1-Dimethylethyl)hexahydro-2,4,7b,11-tetrahydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione; 5H-Dicyclopenta[b,c]furan-3,5a(6H)-diacetic acid, 6-tert-butyl-3a-carboxyhexahydro-α5a,1,2,3,5,7,8-heptahydroxy-α3-methyl-, tri-γ-lactone; Ginkgolide A, 1,7-dihydroxy-, (1β,7β)-; 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)hexahydro-2,4,7b,11-tetrahydroxy-8-methyl-, [1R-(1α,2α,3β,3aS*,4β,6aα,7aα,7bα,8α,10aα,11α,11aR*)]-; BN 52022. Grade: >98%. CAS No. 15291-76-6. Molecular formula: C20H24O11. Mole weigh | |
| Ginkgolide K | Ginkgolide K is extracted from the leaves of Ginkgo biloba L. It promotes angiogenesis after ischemia stroke and promotes astrocyte migration and proliferation after oxygen-glucose deprivation. It improves nerve injury after cerebral ischemia-reperfusion and inhibits PAF-induced platelet aggregation. It also can promote the clearance of A53T mutation alpha-synuclein in SH-SY5Y cells and shows anti- Parkinson's disease activity. It shows neuroprotective effect and anti-oxidative stress on ischemic stroke. Synonyms: 9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)-2,3,10a,11-tetrahydro-4,11-dihydroxy-8-methyl-, (1R,3S,3aS,4R,6aR,7aS,10aR,11R,11aR)-. Grade: 97.5%. CAS No. 153355-70-5. Molecular formula: C20H22O9. Mole weight: 406.38. | |
| GSK2190915 | GSK2190915 is a potent FLAP(5-Lipoxygenase-activating protein) inhibitor. It exhibits excellent preclinical toxicology and pharmacokinetics in rat and dog. It also demonstrated an extended pharmacodynamic effect in a rodent bronchoalveolar lavage (BAL) model. It increased survival time in mice exposed to a lethal intravenous injection of platelet activating factor (PAF). Synonyms: AM-803; AM 803; AM803; 3Fiboflapon; GSK2190915; GSK 2190915; GSK-2190915. Grade: >98%. CAS No. 936350-00-4. Molecular formula: C38H43N3O4S. Mole weight: 637.83. | |
| HZ52 | HZ52 is a novel reversible inhibitor of 5-lipoxygenase, blocking leukotriene synthesis with an IC50 value of 0.7 μM in intact human polymorphonuclear leukocytes. HZ52 was shown to prevent carrageenan-induced pleurisy accompanied by reduced LTB(4) levels and protected mice (10 mg·kg?¹, i.p.) against PAF-induced shock. Synonyms: HZ-52; HZ 52; 2-[4-Chloro-6-(4-phenylanilino)pyrimidin-2-yl]sulfanyloctanoic acid. Grade: ≥98%. CAS No. 1077626-51-7. Molecular formula: C24H26ClN3O2S. Mole weight: 456. | |
| N-Acetyldesloratadine | N-Acetyldesloratadine (SCH-37370) is a potent, orally active dual antagonist of platelet-activating factor (PAF) and histamine. N-Acetyldesloratadine inhibits PAF-induced aggregation of human platelets, with an IC 50 of 0.6 μM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SCH-37370. CAS No. 117796-52-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-116120. | |
| Orsellinic acid | Orsellinic acid is from Chaetomium globosum endophytic. Orsellinic acid can block platelet activating factor (PAF)-mediated neuronal apoptosis without affecting G-protein coupled receptor (PAFR)-mediated neuroprotection, and it can effectively attenuate PAFR-independent neuronal apoptosis. It is a novel benzoquinone ring precursor for antroquinonol and 4-acetylantroquinonol B. It is formed from acetyl-coenzyme Q (CoQ) and malonyl-CoA via polyketide pathway. Synonyms: o-Orsellinic acid; 4,6-Dihydroxy-o-toluic acid. Grade: 99.0%. CAS No. 480-64-8. Molecular formula: C8H8O4. Mole weight: 168.15. | |
| P11 | P11 is a selective inhibitor of platelet-activating factor acetylhydrolases ( PAFAHs ) 1b2 and 1b3 that impairs cancer cell survival. P11 exhibits IC 50 values of ~40 and 900 nM for PAFAH1b2 and 1b3, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 942285-55-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-111053. | |
| platelet-activating factor acetyltransferase | Catalyses the transfer of the acetyl group from 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) to the sn-2 position of lyso-glycerophospholipids containing ethanolamine, choline, serine, inositol or phosphate groups at the sn-3 position as well as to sphingosine and long-chain fatty alcohols. The organyl group can be alkyl, acyl or alk-1-enyl (sometimes also collectively referred to as 'radyl'). Group: Enzymes. Synonyms: PAF acetyltransferase. Enzyme Commission Number: EC 2.3.1.149. CAS No. 9012-30-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2088; platelet-activating factor acetyltransferase; EC 2.3.1.149; 9012-30-0; PAF acetyltransferase. Cat No: EXWM-2088. | |
| prokaryotic ubiquitin-like protein ligase | The enzyme has been characterized from the bacteria Mycobacterium tuberculosis and Corynebacterium glutamicum. It catalyses the ligation of the prokaryotic ubiquitin-like protein (Pup) to a target protein by forming a bond between an ε-amino group of a lysine residue of the target protein and the γ-carboxylate of the C-terminal glutamate of the ubiquitin-like protein (Pup). The attachment of Pup, also known as Pupylation, marks proteins for proteasomal degradation. Group: Enzymes. Synonyms: PafA (ambiguous); Pup ligase; proteasome accessory factor A. Enzyme Commission Number: EC 6.3.1.19. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5721; prokaryotic ubiquitin-like protein ligase; EC 6.3.1.19; PafA (ambiguous); Pup ligase; proteasome accessory factor A. Cat No: EXWM-5721. | |
| (R)-Edelfosine | (R)-Edelfosine is a synthetic lysophospholipid analogue that acts as an inhibitor of phosphatidylinositol phospholipase C (IC50 = 9.6 μM in fibroblasts and adenocarcinoma cells) and an agonist at platelet-activating factor (PAF) receptors. It induces apoptosis in human promyelocytic HL-60 leukemic cells and promonocytic U937 leukemic cells. Synonyms: 3,5,9-Trioxa-4-phosphaheptacosan-1-aminium, 4-hydroxy-7-methoxy-N,N,N-trimethyl-, inner salt, 4-oxide, (7R)-; 3,5,9-Trioxa-4-phosphaheptacosan-1-aminium, 4-hydroxy-7-methoxy-N,N,N-trimethyl-, inner salt, 4-oxide, (R)-; 1-O-Octadecyl-2-O-methyl-sn-glycero-3-phosphocholine; ET 18-OCH3; TLC ELL 12; (R)-2-methoxy-3-(octadecyloxy)propyl (2-(trimethylammonio)ethyl) phosphate; (7R)-4-Hydroxy-7-methoxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphaheptacosan-1-aminium-4-oxide. Grade: >99%. CAS No. 77286-66-9. Molecular formula: C27H58NO6P. Mole weight: 523.73. | |
| Rilapladib | Rilapladib (SB 659032) is a selective Lp-PLA 2 (lipoprotein-associated phospholipase A 2 ) inhibitor with an IC 50 of 230 pM [1]. Rilapladib (SB 659032) is also a PAFR (Platelet Activating Factor Receptor) antagonist [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB 659032. CAS No. 412950-08-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-102004. | |
| Rupatadine | Rupatadine (UR-12592) is a potent, orally active and long-lasting dual PAF/H1 antagonist, with K i s of 0.55 μM and 0.1 μM, respectively. Rupatadine can be used for the research of allergic rhinitis and urticaria [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: UR-12592. CAS No. 158876-82-5. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-13511. | |
| Rupatadine Fumarate | Rupatadine (UR-12592) Fumarate is a potent, orally active and long-lasting dual PAF/H1 antagonist, with K i s of 0.55 μM and 0.1 μM, respectively. Rupatadine Fumarate can be used for the research of allergic rhinitis and urticaria [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: UR-12592 Fumarate. CAS No. 182349-12-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-13511A. | |
| ST271 | ST271 is a potent inhibitor of protein tyrosine kinase ( PTK ), inhibits phospholipase D activation stimulated by fMet-Leu-Phe and PAF, with IC 50 s of 6.7 and 9 μM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 106392-48-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-103097. | |
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