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| Product | Description | |
|---|---|---|
| Para Red | Para Red. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 25g, 100g, 250g, 1Kg. US Biological Life Sciences. |  Worldwide |
| Para red-d4 | Heterocyclic Organic Compound. Alternative Names: 1-(4-Nitrophenylazo)-2-naphthol-d4. CAS No. 1185235-75-9. Molecular formula: C16H7D4N3O3. Mole weight: 297.3. Appearance: Red solid. IUPACName: 1-[(2,3,5,6-tetradeuterio-4-nitrophenyl)diazenyl]naphthalen-2-ol. Catalog: ACM1185235759. |  |
| Para Red-d4 (1-(4-Nitrophenylazo)-2-naphthol-d4) | A biological stain. Group: Biochemicals. Alternative Names: 1-(4-Nitrophenylazo)-2-naphthol-d4. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Para red D6 (Naphthyl D6) | Others2H Labeled Compounds. Alternative Names: 1-[2-(4-Nitrophenyl)diazenyl]- 2-naphthalen-3,4,5,6,7,8-d6-ol. CAS No. 1014689-16-7. Molecular formula: C16D6H5N3O3. Mole weight: 299.31. IUPACName: (1Z) -3, 4, 5, 6, 7, 8-hexadeuterio-1-[ (4-nitrophenyl) hydrazinylidene]naphthalen-2-one. Catalog: ACM1014689167. | |
| 1,2-O-Cyclohexylidene-a-D-xylopentodi-aldo-1,4-fructose | 1,4-Fructofuranosyl-2-cyclohexylidene-α-D-xylopyranoside is a complex sugar analog of paramount significance and specific application in the biomedical realm. Its potential as a reversible inhibitor of glycolysis in cancer cells has been thoroughly investigated, exhibiting a marked reduction in glucose uptake. This unique compound holds promise for future advancements as a targeted treatment for various types of cancer, bestowed with the ability to selectively hamper unwanted metabolic activity. |  |
| 5-(3-Amino-1-propyn-1-yl)-2'-deoxyuridine 5'-(Tetrahydrogen Triphosphate) | 5-(3-Amino-1-propyn-1-yl)-2'-deoxyuridine 5'-(Tetrahydrogen Triphosphate) is an intermediate in the synthesis of Texas Red-5-dUTP, a fluorescence-labelled nucleotide analog. Texas Red-5-dUTP is used diagnostically for detection of rearranged SS18 in formalin-fixed, paraffin-embedded synovial sarcoma. Synonyms: 5-Propargylamino-dUTP; 5-Propargyl-dUTP; 5-Propargylamino-2'-deoxyuridine-5'-Triphosphate. Grades: ≥90% by AX-HPLC. CAS No. 179101-49-6. Molecular formula: C12H18N3O14P3. Mole weight: 521.2. | |
| 5-Iodo-dUTP | 5-Iodo-dUTP is used in the synthesis of Texas Red-5-dUTP, a fluorescence-labelled nucleotide analog. Texas Red-5-dUTP is used diagnostically for detection of rearranged SS18 in formalin-fixed, paraffin-embedded synovial sarcoma. Synonyms: 5-Iodo-2'-deoxyuridine-5'-Triphosphate. Grades: ≥ 95% by HPLC. CAS No. 3731-55-3. Molecular formula: C9H14N2O14P3I (free acid). Mole weight: 594.04 (free acid). | |
| 6-Chloro-5-(2,3-dichlorophenoxy)-2-methylthio-benzimidazole (Triclabendazole) | Triclabendazole is a member of the benzimidazole family of anthelmintics. It is effective against F. hepatica helminths that cause fascioliasis, reducing secreted protease enzyme activities that are critical for the invasion, migration, nutrition, and survival of the parasite.1 In yeast and mammalian cells, triclabendazole was shown to inhibit adenylyl cyclase in the Ras-adenylyl cyclase-protein kinase A nutrient-sensing pathway and to prevent apoptosis induced by the Parkinsons disease-related protein α-synuclein, demonstrating a protective role during various cellular stresses.2,3. Group: Biochemicals. Alternative Names: 5-Chloro-6- (2, 3-dichlorophenoxy) -2- methyl thiobenzimidazole; CGA-89317, egaten; Fasinex; Triclabendazole. Grades: Highly Purified. CAS No. 68786-66-3. Pack Sizes: 25g, 50g, 100g. Molecular Formula: C14H9Cl3N2OS, Molecular Weight: 359.66. US Biological Life Sciences. | Worldwide |
| 9-Tetradecyn-1-ol | 9-Tetradecyn-1-ol is the precursor to the sex pheromones, (Z)-9-tetradecenol (myristoleyl alcohol), (Z)-9-tetradecenal and (Z)-9-tetradecenyl acetate, of Homoeosoma electellum (Sunflower moth), Maliarpha separatella (African white stemborer), Spodoptera exigua (Beet armyworm), Dioryctria resinosella (Red pine shoot moth), Hulstia undulatella (Sugarbeet crown borer), Adoxophyes orana (Summerfruit tortrix), Helicoverpa armigera (Cotton bollworm), Euzophera semifuneralis (American plum borer), Heliothis peltigera (Bordered straw), Ectomyelois ceratoniae (Carob moth), Tyta luctuosa (Four-spotted moth), Macronoctua onusta (Iris borer) and Heliothis virescens (Tobacco budworm). Also, 9-Tetradecyn-1-ol allows access to (E,Z)-3,13-Octadecadien-1-ol, (E,Z)-3,13-Octadecadienyl acetate and (Z,Z)-3,13-Octadecadien-1-ol, pheromones for Zeuzera pyrina (Leopord Moth) and Paranthrene robiniae (Western Poplar Clearwing). Group: Pheromone ingredients. Alternative Names: 9-Tetradecin-1-ol - Tetradec-9-yn-1-ol. CAS No. 60037-69-6. Molecular formula: C14H26O. Mole weight: 210.36. Appearance: Clear, colourless to pale yellow liquid. Purity: 96.0% minimum. Catalog: ACM60037696. | |
| Acetaminophen-13C2,15N | Acetaminophen-13C2,15N is 13C and 15N labeled acetaminophen. Acetaminophen is a metabolite of phenacetin in the body. It reduces the synthesis and release of prostaglandins PGE1, bradykinin and histamine by inhibiting prostaglandin synthase in the hypothalamic thermoregulatory center. Group: Isotope-labeled synthetic intermediates. Alternative Names: Paracetamol-13C2,15N; 4-Acetamidophenol-13C2,15N; 4'-Hydroxyacetanilide-13C2,15N. CAS No. 360769-21-7. Molecular formula: C613C2H915NO2. Mole weight: 154.14. Canonical SMILES: [13CH3][13C]([15NH]C1=CC=C(C=C1)O)=O. Catalog: ACM360769217. | |
| Acetaminophen D-glucuronide | Acetaminophen D-glucuronide, a vital metabolite of acetaminophen, an extensively employed non-prescription remedy for pain alleviation and fever reduction, assumes a pivotal function in dismantling and purging acetaminophen from the organism. Gaining profound comprehension of its synthesis and excreting pathway is paramount in investigating pharmaceutical metabolism and plausible drug interactions. Synonyms: Paracetamol-O-D-glucuronide p-Acetylaminophenol-O-D-glucuronide. CAS No. 16110-10-4. Molecular formula: C14H17NO8. Mole weight: 327.29. | |
| AF 353 | AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. It is a highly potent inhibitor of α,β-meATP-evoked intracellular calcium flux in cell lines expressing recombinant rat and human P2X3 and human P2X2/3 channels. It also blocks human P2X2/3 channel function with marginally reduced potency (pIC50 = 7.3). It significantly reduces this parameter in both groups. It also reduces the inter-contractile interval in control but not in SCI rats. Synonyms: AF353; AF-353; 2,4-Pyrimidinediamine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-; Ro 4; 5-{[5-iodo-2-(1-Methylethyl)-4-(Methyloxy)phenyl]oxy}-2,4-pyrimidinediamine. Grades: >98%. CAS No. 865305-30-2. Molecular formula: C14H17IN4O2. Mole weight: 400.21. | |
| Anti-Parasitic Compound Library | A selection of 336 compounds with anti-parasitic activity, a powerful tool for anti-parasitic drug development. - Contains a wide range of compounds with anti-parasitic activity, including anti-Plasmodium, anti-Leishmania, and anti-filariasis etc. - Detailed instructions, compound structure, target information, activity description, etc. - Multiple assays such as NMR, HPLC/LCMS to ensure correct product structure, high purity and to reduce false positives. Uses: Scientific use. Product Category: L4510. Categories: Anti-Parasitic Compounds Libraries. |  |
| Artemether | Artemether is an antimalarial for the treatment of resistant strains of falciparum malaria.Target: AntiparasiticArtemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. Artemether exhibits the highest activity against juvenile stages of the parasites, while adult worms are significantly less susceptible. There was no indication of neurotoxicity following repeated high doses of artemether given fortnightly for up to 5 months. Artemether-integrated with other control strategies-has considerable potential for reducing the current burden of schistosomiasis in different epidemiological settings. There were remarkably inhibitory effects of artmeter on brain glioma growth and angiogenesis in SD rats and the mechanism that artemether inhibited brain glioma growth might be penetrating the blood-brain barrier and inhibiting angiogenesis. Group: Inhibitors. CAS No. 71963-77-4. Molecular formula: C16H26O5. Mole weight: 298.37. Appearance: Solid. Purity: 0.98. Canonical SMILES: C[C@H]1[C@@H] (OC)O[C@@]2 ([H])[C@]34[C@@] ([C@H] (C)CC[C@]41[H]) ([H])CC[C@@] (O2) (C)OO3. Catalog: ACM71963774. | |
| AS-2444697 HCl | AS-2444697 is a pootent and selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor (IC50 = 21 nM) with 30-fold selectivity for IRAK4 over IRAK1. AS2444697 significantly reduced or showed a decreasing trend in expression and levels of these inflammatory parameters. Synonyms: N-(3-carbamoyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide hydrochloride; AS-2444697; AS 2444697; AS2444697; AS-2444697 HCl; AS-2444697 hydrochloride. CAS No. 1287665-60-4. Molecular formula: C19H21ClN6O4. Mole weight: 432.86. | |
| Bavachalcone | Bavachalcone inhibited osteoclast formation from precursor cells with the IC(50) of approximately 1.5 microg ml(-1). The activation of MEK, ERK, and Akt by receptor activator of nuclear factor kappaB ligand (RANKL), the osteoclast differentiation factor, was prominently reduced in the presence of bavachalcone. The induction of c-Fos and NFATc1, key transcription factors for osteoclastogenesis, by RANKL was also suppressed by bavachalcone. Bavachalcone exhibited a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro. Bavachalcone had stronger inhibition on UGT1A1 and UGT1A7 than corylin which did not inhibit UGT1A1, UGT1A3, UGT1A7, UGT1A8, UGT1A10, and UGT2B4. Data fitting using Dixon and Lineweaver-Burk plots demonstrated the noncompetitive inhibition of bavachalcone against UGT1A1 and UGT1A7-mediated 4-MU glucuronidation reaction. The values of inhibition kinetic parameters (Ki) were 5.41 μ M and 4.51μ M for UGT1A1 and UGT1A7, respectively. Synonyms: Broussochalcone B. Grades: >98%. CAS No. 28448-85-3. Molecular formula: C20H20O4. Mole weight: 324.37. | |
| Benzoyl chloride,4-(2-phenyldiazenyl)- | Heterocyclic Organic Compound. Alternative Names: Azoyl Chloride, 4-Phenylazobenzoyl chloride, p-Phenylazobenzoyl chloride, p-(Phenylazo)benzoyl chloride, Ambsda500034095, 4-(Phenylazo)benzoyl chloride, Azobenzene-4-carbonyl Chloride, 173452_ALDRICH, 4-phenyldiazenylbenzoyl chloride, Benzoyl chloride, 4-(phenylazo)-, Para-(phenylazo)benzoyl chloride, 4-phenyldiazenyl-benzoyl chloride, RYMHZBAYPLCCAC-FOCLMDBBSA-, NSC7955, Benzoyl chloride, p-(phenylazo)-, MolPort-001-780-292, MolPort-003-927-115, CID66910, NSC 7955, EINECS 203-188-4. CAS No. 104-24-5. Molecular formula: C13H9ClN2O. Mole weight: 244.68. Appearance: orange-red crystalline powder. Purity: MP 92.5-94deg. IUPACName: 4-phenyldiazenylbenzoyl chloride. Canonical SMILES: C1=CC=C(C=C1)N=NC2=CC=C(C=C2)C(=O)Cl. Density: 1.21g/cm³. ECNumber: 203-188-4. Catalog: ACM104245. | |
| Bis (ethylenedithio)tetrathiafulvalene | Bis (ethylenedithio)tetrathiafulvalene (BEDT-TTF) is an organic superconducting polymer that is used as an electron donor with a superconducting transition temperature (Tc) of 10K. Uses: Bedt-ttf may be used as a counter-anion with tetrathiocyanatocuprate which can be prepared by the galvanostatic electrocrystallization process. it may also be used in the preparation of novel paramagnetic conductors by synthesizing multifunctional molecular materials with manganese containing complexes. bedt-ttf based doping may be used in the fabrication of a hybrid organic change generation layer which can potentially be used in the development of tandem organic light emitting diodes (oleds). Group: Organic & printed electronics. Alternative Names: BEDT-TTF. CAS No. 66946-48-3. Molecular formula: C10H8S8. Mole weight: 384.65. Appearance: Orange to Amber to Dark red powder to crystal. Purity: >98.0%(T). IUPACName: 2-(5,6-dihydro-[1,3]dithiolo[4,5-b][1,4]dithiin-2-ylidene)-5,6-dihydro-[1,3]dithiolo[4,5-b][1,4]dithiine. Canonical SMILES: C1CSC2=C (S1)S\C (S2)=C3\SC4=C (SCCS4)S3. Catalog: ACM66946483-3. | |
| Carboplatin | Analog of Cisplatin with reduced nephrotoxicity. Carboplatin is a platinum-based antineoplastic drug that damages DNA by forming intrastrand cross-links with neighboring guanine residues. Tumors acquire resistance to these drugs through the loss of DNA-mismatch repair (MMR) activity and the resultant decrease in the induction of programmed cell death. Group: Biochemicals. Alternative Names: (SP-4-2)-Diamimine[1, 1-cyclobutanedi (carboxylato-kO) (2-)]platinum; cis-Diammine (1, 1-cyclobutane dicarboxylato) platinum (II) ; CBDCA; JM-8; Paraplatin. Grades: Purified. CAS No. 41575-94-4. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Carboplatin-d4 ((SP-4-2)-Diamimine[1,1-cyclobutane-d4-di(carboxylato-kO)(2-)]platinum,. cis-Diammine (1, 1-cyclobutane-d4-dicarboxylato)platinum (II), CBDCA-d4, JM-8-d4, Paraplatin-d4) | Analog of Cisplatin with reduced nephrotoxicity. Antineoplastic. Group: Biochemicals. Alternative Names: (SP-4-2)-Diamimine[1,1-cyclobutane-d4-di(carboxylato-kO)(2-)]platinum; cis-Diammine (1, 1-cyclobutane-d4-dicarboxylato)platinum (II); CBDCA-d4; JM-8-d4; Paraplatin-d4. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| CAY10512 | NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. CAY10512 is an analog of Resveratrol that is 100-fold more potent (IC50 = 150 nM) at inhibiting NF-κB activation by TNF-&alpha. Unlike Resveratrol and some other trans-stilbene analogs, CAY10512 does not exhibit antioxidant activity (up to 15 μM) in either the ferric reducing/antioxidant power (FRAP) or total radical antioxidant parameter (TRAP) assays. Synonyms: (E)-2-Fluoro-4?-methoxystilbene. Grades: ≥97%. CAS No. 139141-12-1. Molecular formula: C15H13FO. Mole weight: 228.3. | |
| CAY10575 | NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is activated upon degradation of IκB following IKK-α and IKK-β phosphorylation. IKK-ε, a homolog of IKK-α and IKK-β, can also activate NF-κB. CAY10512 is an analog of Resveratrol that is 100-fold more potent with IC50 of 150 nM at inhibiting NF-κB activation by TNF-&alpha. It does not exhibit antioxidant activity in either the ferric reducing/antioxidant power (FRAP) or total radical antioxidant parameter (TRAP) assays. Synonyms: CAY 10575; CAY-10575. Grades: ≥95%. CAS No. 916985-21-2. Molecular formula: C22H21N3O6S2. Mole weight: 487.6. | |
| Chymostatin | Chymostatin is a SARS-CoV-2 M pro inhibitor. Chymostatin up-regulates endocan and inhibits NF-κBp65 activity. Chymostatin reduces proinflammatory cytokines ( IL-1β and IL-6 ) and HMGB1. Chymostatin shows protective effects against Paraquat-induced acute lung injury. Chymostatin exhibits anticancer activity against lung cancer [1] [2] [3] [4] [5] [6] [7]. Uses: Scientific research. Group: Peptides. CAS No. 9076-44-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P3042. |  |
| CKD-516 HCl | CKD-516 is tubulin inhibitor for solid cancer, which was initiated phase 1 trial in Korea in 2010. CKD-516 selectively disrupted tubulin component of the endothelial cytoskeleton. Serial DCE-MRI showed a significant decrease in K-trans and IAUGC parameters from baseline at 4 h (39.9 % in K-trans; -45.0 % in IAUGC) and at 24 h (-32.2 % in K-trans; -36.5 % in IAUGC), and a significant recovery at 48 h (22.9 % in K-trans; 34.8 % in IAUGC) following administration of CKD-516 at a 0.7-mg/kg dose. When the tumors were stratified according to the initial K-trans value of 0.1, tumors with a high K-trans?>?0.1 which was indicative of having well-developed pre-existing vessels, showed greater reduction in K-trans and IAUGC values. On histologic examination, the degree of necrosis of treated tumors was significantly greater than that of untreated tumors. In summary, CKD-516 is an effective VDA which results in rapid vascular shutdown by targeting the tubulin component of tumor vessels and thus leads to necrosis. Synonyms: Valecobulin hydrochloride; CKD516 hydrochloride; CKD 516 hydrochloride. CAS No. 1240321-53-2. Molecular formula: C26H29ClN6O5S. Mole weight: 573.07. | |
| Dabcyl acid | Dabcyl acid (Dabcyl) is the original dark fluorescence quencher. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: DABCYL; Para-methyl red. CAS No. 6268-49-1. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-D1045. | |
| Demecarium bromide | Demecarium is a parasympathomimetic that acts as an acetylcholinesterase inhibitor. It is one of several topical (applied directly to the affected area) medications used to reduce elevated intraocular pressure (IOP) associated with primary glaucoma in cats, dogs, and other animals. Uses: Cholinesterase inhibitors; miotics. Synonyms: 3, 3'-[1, 10-decanediylbis[ (methylimino)carbonyloxy]]bis[N, N, N-trimethylbenzenaminium Bromide; (m-Hydroxyphenyl)trimethylammonium Bromide Decamethylenebis[methylcarbamate]; (m-hydroxyphenyl)trimethylammonium Bromide Decamethylenebis[methylcarbamate]; Demekarium Bromide; Demekastigmine Bromide; Frumtosnil; Humorsol. Grades: ≥95%. CAS No. 56-94-0. Molecular formula: White Solid. Mole weight: 716.59. | |
| D-Glucono-1,4-lactone | D-Glucono-1,4-lactone is a ubiquitous biochemical compound serving as a paramount precursor for the biosynthesis of L-ascorbic acid. Its latent potential as a paramount reducing compound invigorates its inclusion in numerous medicinal formulations. CAS No. 1198-69-2. Molecular formula: C6H10O6. Mole weight: 178.14. | |
| Dihydrotachysterol | Dihydrotachysterol is a vitamin D that can be regarded as a reduction product of vitamin D2 activated in the liver. It does not require renal hydroxylation like vitamin D2 and vitamin D3. It could stimulate intestinal calcium absorption and increases renal phosphate excretion. It is widely used for hypocalcemic hypoparathyroidism following surgical removal of parathyroids. Synonyms: HSDB 3314; Hytakerol; Parterol; Tachyrol; Dihydral; (1S,3E,4S)-4-Methyl-3-[(2E)-2-[(1R,3aS,7aR)-octahydro-7a-methyl-1-[(1R,2E,4R)-1,4,5-trimethyl-2-hexen-1-yl]-4H-onden-4-ylidene]ethylidene]cyclohexanol; (3β,5E,7E,10α,22E)-9,10-Secoergosta-5,7,22-trien-3-ol; 24-Methyl-9,10-secocholesta-5,7,22-trien-3β-ol; Antitanil; Calcamine; DHT2; Dichystrolum; Dihidrotaquisterol; (5E,7E,22E)-(3S,10S)-9,10-seco-5,7,22-ergostatrien-3-ol. Grades: 98%. CAS No. 67-96-9. Molecular formula: C28H46O. Mole weight: 398.66. | |
| DNDI-6174 | DNDI-6174 is a cytochrome bc1 complex inhibitor with potent in vitro activity against a variety of Leishmania species. DNDI-6174 can reduce parasite burden in animal models of infection [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2868298-43-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-162066. | |
| Eprinomectin B1b | It is a semi-synthetic analogue of avermectin B1b prepared by oxidation of the 4''-hydroxy moiety and reductive amination followed by acetylation. It is the minor component (<10%) of the commercial product for endo- and exo-parasite control, eprinomectin. It is a potent insecticide and acaricide. Synonyms: (4''R)-4''-(Acetylamino)-5-O-demethyl-25-de(1-methylpropyl)-4''-deoxy-25-(1-methylethyl)avermectin A1a; Eprinomectin component B1b. Grades: >99% by HPLC. CAS No. 133305-89-2. Molecular formula: C49H73NO14. Mole weight: 900.10. | |
| Etelcalcetide hydrochloride | Etelcalcetide is a calcium-sensing receptor agonist as a D-amino peptide calcimimetic for the treatment of secondary hyperparathyroidism. It can bind to and activate the CaSR (calcium-sensing receptor) in the parathyroid gland as an allosteric activator, resulting in PTH reduction and suppression. Amgen Inc. announced its submission of a New Drug Application to the FDA for etelcalcetide in Aug 2015. Synonyms: AMG-416; AMG 416; AMG416; Etelcalcetide hydrochloride; KAI-4169; KAI-4169-HCl; ONO-5163; Parsabiv; Telcalcetide; Velcalcetide; Velcalcetide hydrochloride;N-Acetyl-D-cysteinyl-D-alanyl-D-arginyl-D-arginyl-D-arginyl-D-alanyl-D-argininamide disulfide with L-cysteine hydrochloride;1262780-97-1 (free). Grades: >98%. CAS No. 1334237-71-6. Molecular formula: C38H74ClN21O10S2. Mole weight: 1084.72. | |
| ferric-chelate reductase (NADH) | Contains FAD. The enzyme catalyses the reduction of bound ferric iron in a variety of iron chelators (siderophores), resulting in the release of ferrous iron. The plant enzyme is involved in the transport of iron across plant plasma membranes. The enzyme from the bacterium Paracoccus denitrificans can also reduce chromate. cf. EC 1.16.1.9, ferric-chelate reductase (NADPH) and EC 1.16.1.10, ferric-chelate reductase [NAD(P)H]. Group: Enzymes. Synonyms: ferric chelate reductase (ambiguous); iron chelate reductase (ambiguous); NADH:Fe3+-EDTA reductase; NADH2:Fe3+ oxidoreductase; ferB (gene name); Fe(II):NAD+ oxidoreductase. Enzyme Commission Number: EC 1.16.1.7. CAS No. 120720-17-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1072; ferric-chelate reductase (NADH); EC 1.16.1.7; 120720-17-4; ferric chelate reductase (ambiguous); iron chelate reductase (ambiguous); NADH:Fe3+-EDTA reductase; NADH2:Fe3+ oxidoreductase; ferB (gene name); Fe(II):NAD+ oxidoreductase. Cat No: EXWM-1072. |  |
| Flubendazole | Flubendazole is an anthelmintic drug based on altering microtubule structure, inhibition of tubulin polymerization and disruption of microtubule function. Flubendazole induces apoptosis in human colorectal cancer (CRC) by blocking the STAT3 signaling axis and activation of autophagy. Flubendazole induces P53 expression and reduced Cyclin B1 and p-cdc2 expression. Flubendazole is an antitumor agent. Flubendazole can be used for worm and intestinal parasites [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 31430-15-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0294. | |
| Flunarizine | Flunarizine is a selective calcium entry blocker, which has calmodulin binding properties and histamine H1 blocking activity. It may help to reduce the severity and duration of attacks of paralysis and is effective in rapid onset dystonia-parkinsonism. It is effective in the prophylaxis of migraine, vascular disease, occlusive peripheral, vertigo of central and peripheral origin. It is used as an adjuvant in the therapy of epilepsy. It has been shown to significantly reduce headache frequency and severity in both adults and children. It was discovered at Janssen Pharmaceutica in 1968. It has been listed. Uses: Flunarizine is effective in the prophylaxis of migraine, vascular disease, occlusive peripheral, vertigo of central and peripheral origin. it is used as an adjuvant in the therapy of epilepsy. Synonyms: R-14950; R 14950; R14950; Sibelium; Flunarizinum; Flunarizina; (E)-1-[Bis-(p-fluorophenyl)methyl]-4-cinnamylpiperazine; 1-[Bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propenyl]piperazine; Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)-, (E)-. Grades: 95%. CAS No. 52468-60-7. Molecular formula: C26H26F2N2. Mole weight: 404.50. | |
| Fluorofenidone | Fluorofenidone is a NADPH-oxidase inhibitor. Fluorofenidone Inhibits UUO/IRI-Induced Renal Fibrosis by Reducing Mitochondrial Damage. Fluorofenidone protects liver against inflammation and fibrosis by blocking the activation of NF-κB pathway. Fluorofenidone attenuates paraquat - induced pulmonary fibrosis by regulating the PI3K/Akt/mTOR signaling pathway and autophagy. Fluorofenidone inhibits apoptosis of renal tubular epithelial cells in rats with renal interstitial fibrosis. Group: Inhibitors. CAS No. 848353-85-5. Molecular formula: C12H10FNO. Mole weight: 203.22. Appearance: Solid powder. Purity: >98%. IUPACName: 1-(3-Fluorophenyl)-5-methylpyridin-2-one. Canonical SMILES: O=C1C=CC(C)=CN1C2=CC=CC(F)=C2. Catalog: ACM848353855. | |
| fumarate reductase (quinol) | The enzyme, which is found in anaerobic and facultative organisms such as bacteria, parasitic helminthes, and lower marine organisms, utilizes low potential quinols, such as menaquinol and rhodoquinol, to reduce fumarate as the final step of an anaerobic respiratory chain. The enzyme is known as complex II of the electron transfer chain, similarly to EC 1.3.5.1, succinate dehydrogenase (quinone), to which it is closely related. Group: Enzymes. Synonyms: FRD; menaquinol-fumarate oxidoreductase; succinate dehydrogenase (menaquinone); succinate:menaquinone oxidoreductase; fumarate reductase (menaquinone); complex II (ambiguous). Enzyme Commission Number: EC 1.3.5.4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1388; fumarate reductase (quinol); EC 1.3.5.4; FRD; menaquinol-fumarate oxidoreductase; succinate dehydrogenase (menaquinone); succinate:menaquinone oxidoreductase; fumarate reductase (menaquinone); complex II (ambiguous). Cat No: EXWM-1388. | |
| Glutathione Reductase from Human, Recombinant | Glutathione reductase enzyme is a homodimeric enzyme containing 1 FAD molecule and 1 NADPH binding domain per subunit., Both human GR (hGR) and Plasmodium falciparum GR (PfGR) are essential for the survival of the malaria parasite within the human erythrocyte. Thus, this enzyme may be used for studies of candidate anti-malaria reagents. Group: Enzymes. Synonyms: glutathione-disulfide reductase; glutathione reductase; glutathione reductase (NADPH); NADPH-glutathione reductase; GSH reductase; GSSG reductase; NADPH-GSSG reductase; glutathione S-reductase; NADPH:oxidized-glutathione oxidoreductase; EC 1.8.1.7; 9001-48-3; GR. Enzyme Commission Number: EC 1.8.1.7. CAS No. 9001-48-3. GR. Activity: > 10 units/mg protein. Storage: -20°C. Form: buffered aqueous solution; Solution containing 25 mM Tris-HCl, pH 7.4, 1 mM EDTA, and 50% (v/v) glycerol. Source: E. coli. Species: Human. glutathione-disulfide reductase; glutathione reductase; glutathione reductase (NADPH); NADPH-glutathione reductase; GSH reductase; GSSG reductase; NADPH-GSSG reductase; glutathione S-reductase; NADPH:oxidized-glutathione oxidoreductase; EC 1.8.1.7; 9001-48-3; GR. Cat No: NATE-0320. | |
| GNF179 | GNF179 exhibits a low clearance (CL=22 ml/min/kg, ~25% of hepatic blood flow in mice), a large volume of distribution (steady-state volume of distribution, Vss=11.8 l/kg), a moderate residence time (MRT=9 hours) and suitable terminal half-life (t1/2=8.9 hours). GNF179 reduced Plasmodium berghei parasitemia levels by 99.7% with a single 100 mg/kg oral dose, and prolonged mouse survival by an average of 19 days. GNF179 was able to protect against an infectious P. berghei sporozoite challenge with a single oral dose at 15 mg/kg while NITD609 was not. Synonyms: GNF 179; GNF-179. Grades: >98%. CAS No. 1261114-01-5. Molecular formula: C22H23ClFN5O. Mole weight: 427.9. | |
| GNF179 Metabolite | GNF179 exhibits a low clearance (CL=22 ml/min/kg, ~25% of hepatic blood flow in mice), a large volume of distribution (steady-state volume of distribution, Vss=11.8 l/kg), a moderate residence time (MRT=9 hours) and suitable terminal half-life (t1/2=8.9 hours). GNF179 reduced Plasmodium berghei parasitemia levels by 99.7% with a single 100 mg/kg oral dose, and prolonged mouse survival by an average of 19 days. GNF179 was able to protect against an infectious P. berghei sporozoite challenge with a single oral dose at 15 mg/kg while NITD609 was not. Synonyms: GNF 179 Metabolite; GNF-179 Metabolite. Grades: >98%. CAS No. 1310455-86-7. Molecular formula: C14H16FN3. Mole weight: 245.3. | |
| GR24 | (Rac)-GR24 (Strigolactone GR24) is a plant hormone analog. (Rac)-GR24 can mimic the natural germination stimulus of parasitic plant seeds, promoting seed germination in the absence of host plants, thereby reducing the number of parasitic seeds in the soil. (Rac)-GR24 can be used in agricultural research [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Strigolactone GR24. CAS No. 76974-79-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-129038. | |
| Isomalt | Isomalt. Synonyms: Hydrogenated isomaltulose; hydrogenated palatinose. CAS No. 64519-82-0. Product ID: PE-0494. Category: Sweetening agent. Product Keywords: Pharmaceutical Excipients; Excipients for Solid Dosage Form; Isomalt; Sweeteners Excipients; Sweetening agent; 64519-82-0; 64519-82-0. UNII: S870P55O2W. Stability and Storage Conditions: Isomalt has very good thermal and chemical stability. When it is melted, no changes in the molecular structure are observed. It exhibits considerable resistance to acids and microbial influences.Isomalt is non-hygroscopic, and at 25°C does not significantly absorb additional water up to a relative humidity (RH) of 85%; paracetamol (acetaminophen) tablets based on isomalt were stored for 6 months at 85% RH at 208C and retained their physical aspect. If stored under normal ambient conditions, isomalt is chemically stable for many years. When it is stored in an unopened container at 20°C and 60% RH, a re-evaluation after 3 years is recommended. Isomalt does not undergo browning reactions; it has no reducing groups, and therefore it does not react with other ingredients in a formulation (e.g. with amines in Maillard reactions). Source and Preparation: Isomalt is produced from food-grade sucrose in a two-stage process.Beet sugar is converted by enzymatic transglucosidation into the reducing disaccharide isomaltulose. This undergoes catalytical hydrogenation to produce isomalt. Safety: Isomal |  |
| L-Psicose | L-Psicose, the naturally-occurring monosaccharide paramount in the biomedical field, garners significant attention owing to its extensive exploration in the realm of diabetes management, obesity reduction, and dental caries prevention. Moreover, its involvement as a substitute sweetener in an array of consumables further stems from its remarkably diminished caloric composition and marginal influence on glycemic indices. Synonyms: Psicose, L-; L-Allulose; L-ribo-2-Hexulose. Grades: ≥95%. CAS No. 16354-64-6. Molecular formula: C6H12O6. Mole weight: 180.16. | |
| Methoctramine tetrahydrochloride | Methoctramine is a selective M2 muscarinic acetylcholine receptor (mAChR) antagonist. Study shows that methoctramine inhibited the bradycardia induced by both vagal stimulation and ACh (ED50: 38 +/- 5 and 38 +/- 9 nmol kg-1, respectively), and facilitated vagally-induced bronchoconstriction (ED50: 58 +/- 5 nmol kg-1). At higher concentrations, methoctramine reduced responses to both nerve stimulation and exogenous ACh, indicating blockade of post-junctional muscarinic M3 receptors. Uses: Parasympatholytics. Synonyms: Methoctramine; N, N'-bis[6-[ (2-methoxyphenyl) methylamino]hexyl]octane-1, 8-diamine tetrahydrochloride. Grades: ≥95%. CAS No. 104807-46-7. Molecular formula: C36H62N4O2·4HCl. Mole weight: 728.8. | |
| Naphthoquine phosphate | Naphthoquine phosphate and artemisinine are two antimalarials developed in China. Both drugs have proven to be efficacious and well tolerated as monotherapy as well as in combination in patients suffering from malaria. The Co-naphthoquine, a novel antimalarial combination, is an oral fixed combination tablet of the naphthoquine phosphate and artemisinine. Artemisinin is characterised by a rapid onset of schizonticidal action and a short half-life. Parasite clearance is, however, often incomplete when it is employed as a single agent unless high dosages are used over several days, but such a regimen may reduce patient compliance and increase the danger of toxicity. Naphthoquine phosphate, by contrast, has a slower onset of action and a longer half-life, associated with a low recrudescence rate. Synonyms: 1-Naphthalenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[[(1,1-dimethylethyl)amino]methyl]-5,6,7,8-tetrahydro-, phosphate (1:2) (salt); 2-((tert-butylamino)methyl)-4-((7-chloroquinolin-4-yl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol bis(phosphate); Naphthoquine diphosphate. Grades: >98%. CAS No. 173531-58-3. Molecular formula: C24H34ClN3O9P2. Mole weight: 605.94. | |
| Naringin | Naringin. Applications: 1.anti-inflammatory, anti-viral, anti-mutation, anti-carcinogen. 2.hypotensive activity, function as urogastrone, alleviating pain.3.tranquilizing, lowering blood viscosity , reduce the emerge of the thrombus. Group: Others. Synonyms: Naringin; 10236-47-2. CAS No. 10236-47-2. Purity: 98%, HPLC. Mole weight: C27H32O14; 580.53. Appearance: light white powder. Storage: 24 months with original packing under 18°C. Store in cool dry place,avoid sunlight and high temperature. Source: Extracted from the fruit of Citrus paradisi. Naringin; 10236-47-2; plant extract. Pack: 1kg, 5kg, 10kg aluminum foil vacuum bag; or 20kg, 25kg Fiber Drum. Cat No: EXTW-206. | |
| Native Bovine Protein Disulfide Isomerase | Protein Disulfide Isomerase (PDI) has the C-terminal ER retention sequence Lys-Asp-Glu-Leu. It has active, intracellular traffic to different cell compartments. PDI supports internalization of Chlamydia, cholera and diphtheria toxins in some hosts. PDI is required for Sindbis virus infection and aids in reducing HIV gp120 protein thiols. PDI facilitates formation of the correct disulfide bonds by promoting rapid reshuffling of disulfide pairings. Protein disulfide isomerase (pdi) from bovine liver is a homodimer with a molecular weight of 107 kda (gel filtration) and the molecular weight of the monomer has been reported at 57 kda (sds-page). the enzyme is a glycoprotein ... is mainly l ocated in the er, where it assists in protein-folding and thiol-disulfide exchanges. it is used to study functional role of pdi in parasite infection and the interaction between macrophage pdi and l. chagasi. Group: Enzymes. Synonyms: Protein disulfide isomerase; PDI; EC 5.3.4.1; 37318-49-3; S-S rearrangase. Enzyme Commission Number: EC 5.3.4.1. CAS No. 37318-49-3. Purity: >95% (SDS-PAGE). PDI. Activity: 100-400 units/mg protein. Storage: -20°C. Form: Lyophilized powder containing potassium phosphate buffer salts and stabilizer. Source: Bovine liver. Species: Bovine. Protein disulfide isomerase; PDI; EC 5.3.4.1; 37318-49-3; S-S rearrangase. Cat No: NATE-0533. | |
| Native Staphylococcus aureus α-Hemolysin | α-Hemolysin is a 33 kDa extracellular protein secreted by most strains of pathogenic Staphylococcus aureus. It is selectively hemolytic and has a marked preference for rabbit red blood cells. It induces dermonecrosis, spastic muscle paralysis, and it is lethal for laboratory animals. The toxin must be in the monomeric form to initially bind to a membrane and specific receptors are not required for binding. Upon binding to biological membranes and/or artificial membranes, self-oligomerization occurs, resulting in ring structures (hexameric aggregates) believed to represent transmembrane pores, which are permeable to ions and small metabolites. Group: Enzymes. Synonyms: α-Hemolysin; 94716-94-6; α-Toxin. α-Hemolysin. Activity: > 10,000 units/mg protein. Storage: 2-8°C. Source: Staphylococcus aureus. α-Hemolysin; 94716-94-6; α-Toxin. Cat No: NATE-0753. | |
| nitrite reductase (NO-forming) | The reaction is catalysed by two types of enzymes, found in the perimplasm of denitrifying bacteria. One type comprises proteins containing multiple copper centres, the other a heme protein, cytochrome cd1. Acceptors include c-type cytochromes such as cytochrome c-550 or cytochrome c-551 from Paracoccus denitrificans or Pseudomonas aeruginosa, and small blue copper proteins such as azurin and pseudoazurin. Cytochrome cd1 also has oxidase and hydroxylamine reductase activities. May also catalyse the reaction of hydroxylamine reductase (EC 1.7.99.1) since this is a well-known activity of cytochrome cd1. Group: Enzymes. Synonyms: cd-cytochrome nitrite reductase; [nitrite reductase (cytochrome)] [misleading, see comments.]; cytochrome c-551:O2, NO2+ oxidoreductase; cytochrome cd; cytochrome cd1; hydroxylamine. Enzyme Commission Number: EC 1.7.2.1. CAS No. 9080-3-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1616; nitrite reductase (NO-forming); EC 1.7.2.1; 9080-03-9; cd-cytochrome nitrite reductase; [nitrite reductase (cytochrome)] [misleading, see comments.]; cytochrome c-551:O2, NO2+ oxidoreductase; cytochrome cd; cytochrome cd1; hydroxylamine (acceptor) reductase; methyl viologen-nitrite reductase; nitrite reductase (cytochrome; NO-forming). Cat No: EXWM-1616. | |
| nitrous-oxide reductase | The reaction is observed only in the direction of nitrous oxide reduction. Contains the mixed-valent dinuclear CuA species at the electron entry site of the enzyme, and the tetranuclear Cu-Z centre in the active site.In Paracoccus pantotrophus, the electron donor is cytochrome c552. Group: Enzymes. Synonyms: nitrous oxide reductase; N2O reductase; nitrogen:(acceptor) oxidoreductase (N2O-forming). Enzyme Commission Number: EC 1.7.2.4. CAS No. 55576-44-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1619; nitrous-oxide reductase; EC 1.7.2.4; 55576-44-8; nitrous oxide reductase; N2O reductase; nitrogen:(acceptor) oxidoreductase (N2O-forming). Cat No: EXWM-1619. | |
| Oleoyl ethyl amide | Oleoyl ethyl amide is a fatty acid amide hydrolase (FAAH) inhibitor with potential analgesic and anxiolytic activity. It altered sensory urodynamic parameters and reduced bladder overactivity in female rats. Synonyms: OEtA; N-Ethyloleamide; (1Z)-N-Ethyloctadec-9-enimidate. Grades: ≥98%. CAS No. 85075-82-7. Molecular formula: C20H39NO. Mole weight: 309.5. | |
| para-Hydroxy Atorvastatin Lactone | para-Hydroxy Atorvastatin Lactone is metabolite of Atorvastatin, a selective, competitive inhibitor of HMG-CoA reductase. Synonyms: 5-(4-Fluorophenyl)-N-(4-hydroxyphenyl)-2-(1-Methylethyl)-4-phenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxaMide; 4-Hydroxy Atorvastatin Lactone (EP); Atorvastatin 4-Hydroxy Lactone. Grades: > 95%. CAS No. 163217-70-7. Molecular formula: C33H33FN2O5. Mole weight: 556.64. | |
| Pararosaniline chloride certified | Pararosaniline chloride certified. Group: Biochemicals. Alternative Names: Basic parafuchsin; Basic red 9; CI 425. Grades: Highly Purified. CAS No. 569-61-9. Pack Sizes: 500g, 1kg, 2kg, 5kg. US Biological Life Sciences. | Worldwide |
| Pararosaniline hydrochloride | Pararosaniline hydrochloride (Basic red 9) is a pH-responsive basic dye, as a biological stain to track certain proteins. The pH of the acidified Pararosaniline hydrochloride reagent has a significant effect on the color and the maximum absorption wavelength (λmax) of the reaction system, with its optimum pH 0.48 and a λmax at 549?nm. Pararosaniline hydrochloride is also a strong modifier of RNA splicing. Pararosaniline hydrochloride has been used in the analysis of SO 2 and formaldehyde and staining of bacteria or other organisms. Pararosaniline hydrochloride is extensively used in industries like textile, printing, paper, cosmetic, and leather [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: Basic red 9. CAS No. 569-61-9. Pack Sizes: 10 g; 25 g. Product ID: HY-W127770. | |
| Phosphonomycin Calcium salt | It is produced by the strain of Str. fradiae NRRL-3417, Str. viridchromogenes NRRL-3413. It's an antibiotic that contains phosphorus. It has anti-gram positive bacterial and negative bacterial activity, inorganic phosphorus and sodium chloride can reduce its activity. It has protective effect on mice infected with Staphylococcus aureus, Salmonella typhi and Salmonella paratyphi B by oral administration. Synonyms: (-)-Phosphonomycin Calcium salt; Calcium fosfomycin; fosfomycin calcium; Fosmicin; Phosphonic acid, [(2R,3S)-3-methyloxiranyl]-, calcium salt (1:1); Phosphonic acid, (1,2-epoxypropyl)-, calcium salt (1:1), (1R,2S)-(-)-; Phosphonic acid, P-[(2R,3S)-3-methyl-2-oxiranyl]-, calcium salt (1:1); Phosphonic acid, (3-methyloxiranyl)-, calcium salt (1:1), (2R-cis)-. Grades: 98%. CAS No. 26016-98-8. Molecular formula: C3H5O4P.Ca. Mole weight: 176.12. | |
| Potassium Alginate | Potassium alginate occurs as a white to yellowish, fibrous or granular powder; it is almost odorless and tasteless. Synonyms: Alginic acid, potassium salt; E402; Improved Kelmar; potassium polymannuronate. CAS No. 9005-36-1. Product ID: PE-0563. Molecular formula: (C6H7O6K)n. Category: Emulsifying Agents; Stabilizing Agents; Suspending Agents; Thickening Agents. Product Keywords: Stabilizers; Emulsifier Excipients; Suspending Agents; ; PE-0563; Potassium Alginate; Emulsifying Agents; Stabilizing Agents; Suspending Agents; Thickening Agents; (C6H7O6K)n; 9005-36-1. UNII: 44ZPJ5W2J1. Chemical Name: Potassium alginate. Grade: Pharmceutical Excipients. Stability and Storage Conditions: In the solid state, potassium alginate is a stable material that is not prone to microbial spoilage. Over time, a slow reduction in the degree of polymerization can occur, which may be reflected in a reduction in the viscosity of solutions. As both temperature and moisture can impair the performance of potassium alginate, storage below 25°C is recommended. Potassium alginate solutions are stable at pH 4-10; long-term storage outside this range can result in depolymerization of the polymer through hydrolysis. Gelation or precipitation of the alginate can occur at pH values less than 4. Liquid or semisolid alginate formulations should be preserved: suitable preservatives are sodium benzoate, potassium sorbate, or parabens. Potassium algin | |
| Procodazole | Procodazole, widely used as an immunomodulator against viral and bacterial infections, after administration it reduced the parasitic burden. Synonyms: 3-(1H-benzimidazol-2-yl)propanoic acid benzimidazolyl-2-propionic acid procodazol propazole propazole, monosodium salt. CAS No. 23249-97-0. Molecular formula: C10H10N2O2. Mole weight: 190.20. | |
| Proguanil hydrochloride | Proguanil hydrochloride, an antimalarial prodrug, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor. Uses: Proguanil (chlorguanide) may be used in anti-parasitic protozoan drug development to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an antimalarial drug. Group: Solvents. Alternative Names: Chlorguanide, N1- (4-Chlorophenyl) -N5-isopropylbiguanide, Proguanil hydrochloride. CAS No. 637-32-1. Molecular formula: C11H17Cl2N5. Mole weight: 290.19. IUPACName: hydrogen 1- ({amino[ (4-chlorophenyl) amino]methylidene}amino) -N'- (propan-2-yl) methanimidamide chloride. Canonical SMILES: [H+]. [Cl-]. CC(C)N=C(N)N=C(N)NC1=CC=C(Cl)C=C1. ECNumber: 211-283-7. Catalog: ACM637321. | |
| Propylparaben | Propylparaben (Propyl parahydroxybenzoate) is an antibacterial preservative that can be produced by plants and bacteria. Propylparaben is commonly used in cosmetics, pharmaceuticals and foods. Propylparaben disrupts follicular growth and steroidogenic function by altering cell cycle, apoptosis and steroidogenic pathways. Propylparaben also reduced sperm count and motility in rats [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Natural products. Alternative Names: Propyl parahydroxybenzoate; Propyl 4-hydroxybenzoate. CAS No. 94-13-3. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-N2026. | |
| Propylparaben (Standard) | Propylparaben (Standard) is the analytical standard of Propylparaben. This product is intended for research and analytical applications. Propylparaben (Propyl parahydroxybenzoate) is an antibacterial preservative that can be produced by plants and bacteria. Propylparaben is commonly used in cosmetics, pharmaceuticals and foods. Propylparaben disrupts follicular growth and steroidogenic function by altering cell cycle, apoptosis and steroidogenic pathways. Propylparaben also reduced sperm count and motility in rats [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Natural products. CAS No. 94-13-3. Pack Sizes: 50 mg; 100 mg; 250 mg. Product ID: HY-N2026R. | |
| Pyrimethamine | Pyrimethamine (Pirimecidan) is a potent, orally active dihydrofolate reductase (DHFR) inhibitor. Pyrimethamine is an antimalarial agent. Pyrimethamine affects the nucleoprotein metabolism of malarial parasites by interference in the folic - folinic acid systems and affects cell division by inhibiting the conversion of dihydrofolate to tetrahydrofolate [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Pirimecidan; Pirimetamin; RP 4753. CAS No. 58-14-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-18062. | |
| RJR-2403 | At concentrations up to 1 mM, RJR-2403 does not significantly activate nAChRs in PC12 cells, muscle type nAChRs or muscarinic receptors. Dose-response curves for agonist-induced ileum contraction indicate that RJR-2403 is less than one-tenth as potent as nicotine with greatly reduced efficacy. RJR-2403 does not antagonize nicotine-stimulated muscle or ganglionic nAChR function (IC50 > 1 mM). Chronic exposure of M10 cells to RJR-2403 (10 microM) results in an up-regulation of high-affinity nAChRs phenomenologically similar to that seen with nicotine. RJR-2403 significantly improved passive avoidance retention after scopolamine-induced amnesia and enhanced both working and reference memory in rats with ibotenic acid lesions of the forebrain cholinergic projection system in an 8-arm radial maze paradigm. By comparison, RJR-2403 was 15 to 30-fold less potent than nicotine in decreasing body temperature, respiration, Y-maze rears and crosses and acoustic startle response. Metanicotine was about 5-fold less potent than nicotine in the tail-flick test after s.c administration, but slightly more potent after central administration. Synonyms: Rivanicline; Metanicotine; RJR-2403; RJR 2403; RJR2403; Metanicotine; Rivanicline oxalate. Grades: >98%. CAS No. 15585-43-0. Molecular formula: C10H14N2. Mole weight: 162.23. | |
| RSM-932A | RSM-932A is a novel anticancer drug. Its target is the human choline kinase alpha. Choline kinase alpha is an enzyme involved in increased lipid metabolism of cancer cells. RSM-932A can reduce parasitemia and induce the accumulation of trophozoites and schizonts, blocking intraerythrocytic development and interfering with parasite egress or invasion. Uses: Anticancer. Synonyms: RSM-932A; RSM 932A; RSM932A; TCD 717; TCD717; TCD-717.1,1'-([1,1'-biphenyl]-4,4'-diylbis(methylene))bis(4-((4-chlorophenyl)(methyl)amino)quinolin-1-ium) bromide. Grades: 98%. CAS No. 850807-63-5. Molecular formula: C46H38Br2Cl2N4. Mole weight: 877.55. | |
| Sinapinic acid | Sinapinic acid (Sinapic acid) is a phenolic compound isolated from Hydnophytum formicarum Jack. Rhizome, acts as an inhibitor of HDAC , with an IC 50 of 2.27 mM [1] , and also inhibits ACE-I activity [2]. Sinapinic acid posssess potent anti-tumor activity, induces apoptosis of tumor cells [1]. Sinapinic acid shows antioxidant and antidiabetic activities [2]. Sinapinic acid reduces total cholesterol, triglyceride, and HOMA-IR index, and also normalizes some serum parameters of antioxidative abilities and oxidative damage in ovariectomized rats [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Sinapic acid. CAS No. 530-59-6. Pack Sizes: 10 mM * 1 mL; 1 g. Product ID: HY-W009732. | |
| Sodium 4-aminosalicylate dihydrate | Sodium 4-aminosalicylate (Sodium para-Aminosalicylic acid) dihydrate is para-aminosalicylic acid (PAS), a dihydrofolate reductase ( DHFR ) inhibitor and antituberculous agent. PAS is incorporated into the folate pathway via dihydropteroate synthase (DHPS) and dihydrofolate synthase (DHFS) to generate the hydroxydihydrofolate antimetabolite, which in turn inhibits DHFR enzyme activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4-Aminosalicylic acid sodium salt dihydrate. CAS No. 6018-19-5. Pack Sizes: 10 mM * 1 mL; 5 g. Product ID: HY-I0447A. | |
| Spiro[9H-fluorene-9, 9'-[9H]xanthene]-2, 2', 7, 7'-tetramine | Spiro[9H-fluorene-9, 9'-[9H]xanthene]-2, 2', 7, 7'-tetramine (X60) is a hole transporting material (HTM) with a nonplanar 3D structure which reduces the electronic coupling and charge recombination. It can be used as a starting material in the fabrication of green and cost effective p-type organic semiconductors. X60 is cheaper alternative to Spiro-OMeTAD. X60 is a spiro[fluorene-9,9'-xanthene] (SFX) based organic hole transport material (HTM). Devices with X60 as HTM showed high power conversion efficiencies (PCEs) amounting to 7.30% in solid-state dye-sensitized solar cells (ssDSCs) and 19.84% in perovskite solar cells (PSCs). These results are competitive with the reported record PCEs of ssDSC and PSC devices based on the well-known HTM Spiro-OMeTAD. In addition, almost no hysteretic behavior could be observed in the X60-based PSCs, and the photovoltaic parameters of the devices are not affected by the scan rates used. Uses: X60 can be used as a conducting polymer in the formation of perovskite based solar cells with high efficiency. Group: Perovskite materials. Alternative Names: N2, N2, N7, N7, N2', N2', N7', N7'-octakis(4-methoxyphenyl)spiro[9H-fluorene-9, 9'-[9H]xanthene]-2, 2', 7, 7'-tetramine, X60. CAS No. 1887794-22-0. Molecular formula: C81H68N4O9. Mole weight: 1241.43. Appearance: beige; solid. Canonical SMILES: COC1=CC=C (C=C1)N (C2=CC=C (OC)C=C2)C3=CC=C4C (C5 (C6= | |
| Sudan R | Sudan dyes and para red in food. Group: Biochemicals. Alternative Names: 1-[2- (2-Methoxyphenyl) diazenyl]-2-naphthalenol. Grades: Highly Purified. CAS No. 1229-55-6. Pack Sizes: 250g, 500g, 1kg, 2kg, 5kg. US Biological Life Sciences. | Worldwide |
| Sudan Red 7B (Solvent Red 19) 98+% | Sudan dyes and para red in food. Group: Biochemicals. Alternative Names: Solvent Red 19; CI 265. Grades: Reagent Grade. CAS No. 6368-72-5. Pack Sizes: 25g, 100g, 250g. US Biological Life Sciences. | Worldwide |
| Tenapanor | Tenapanor (AZD1722) is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor has the potential for the research of hyperphosphatemia [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD1722; RDX5791. CAS No. 1234423-95-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15991. | |
| Tenapanor hydrochloride | Tenapanor (AZD1722) hydrochloride is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor hydrochloride reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor hydrochloride has the potential for the research of hyperphosphatemia [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD1722 hydrochloride; RDX5791 hydrochloride. CAS No. 1234365-97-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15991A. | |
| Tenofovir maleate | Tenofovir hydrate reduces the viral cytopathic effect of HIV-1(IIIB), HIV-2(ROD) and HIV(EHO) with EC50 of 1.15 μg/mL, 1.12 μg/mL and 1.05 μg/mL in MT-4 cells. Tenofovir hydrate also reduces the viral cytopathic effect of SIV(mac251) , SIV(B670) ,SHIV(89.6) and SHIV(RTSHIV). Tenofovir hydrate inhibits hepatitis B virus (HBV) activity in HepG2 2.2.15, HepAD38 and HepAD79 cells. Tenofovir hydrate (4 μM) completely inhibits the growth of HIVIIIB in MT-2 cells. Tenofovir hydrate inhibits synthesis of negative strand strong-stop DNA with IC50 of 9 ?M for wild-type RT, 6 ?M for M184V RT and 50 ?M for K65R RT. Tenofovir hydrate (30 mg/kg) completely prevents SIV infection in all macaques without toxicity. Tenofovir hydrate treatment reduces plasma viral RNA levels to undetectable, with parallel decreases in the infectivity of plasma and infectious cells in peripheral blood mononuclear cells and cerebrospinal fluid (CSF) and stabilization of CD4+ T-cell numbers. Tenofovir hydrate (30 mg/kg, s.c.) completely abrogates HIV infection via intravaginal exposure in pig-tailed macaques. Synonyms: Viread maleate; GS 1278 maleate; GS1278 maleate; GS-1278 maleate; PMPA maleate; TDF maleate. Grades: >98%. CAS No. 1236287-04-9. Molecular formula: C13H18N5O8P. Mole weight: 403.28. | |
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