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| Product | Description | |
|---|---|---|
| Phosphoinositide 3 Kinase, p110 gamma (His) p101 (GST), Recombinant, Human (PI3K) | PI3K is highly expressed in cells of hematopoietic origin. It plays an important role in dendritic cell (DC) trafficking and in the activation of specific immunity. PI3K -/- mice showed a reduced ability to respond to chemokines, and had a selective defect in the number of skin Langerhans cells and in lymph node CD8alpha-DCs. In macrophages, the chemokine RANTES/CCL5 activates the small GTPase Rac1 and its downstream target PAK2. This response depends on Gi activation and largely on the subsequent triggering of PI3K. Distinct regions within the p101 regulatory subunit primary stucture are responsible for interaction with PI3K and Gbg. The PI3K binding site is confined to the N-terminus, whereas binding to Gbg is mediated by the C-terminus of p101. The PI3K catalytic subunit carries a N-terminal His6 affinity Tag, whereas the p101 adaptor subunit carries a N-terminal GST Tag. The molecular weight for p110g chain is 126.3kD (without Tag) and the p101 chain 101kD (without Tag). Group: Molecular Biology. Grades: Highly Purified. Pack Sizes: custom. US Biological Life Sciences. |  Worldwide |
| phosphoinositide 5-phosphatase | These enzymes can also remove the 5-phosphate from Ins(1,4,5)P3 and/or Ins(1,3,4,5)P4. They are a diverse family of enzymes, with differing abilities to catalyse two or more of the four reactions listed. They are thought to use inositol lipids rather than inositol phosphates as substrates in vivo. All of them can use either or both of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 as substrates; this is the main property that distinguishes them from EC 3.1.3.56, inositol-polyphosphate 5-phosphatase. Group: Enzymes. Synonyms: type II inositol polyphosphate 5-phosphatase; triphosp. Enzyme Commission Number: EC 3.1.3.36. CAS No. 9036-1-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3639; phosphoinositide 5-phosphatase; EC 3.1.3.36; 9036-01-5; type II inositol polyphosphate 5-phosphatase; triphosphoinositide phosphatase; IP3 phosphatase; PtdIns(4,5)P2 phosphatase; triphosphoinositide phosphomonoesterase; diphosphoinositide phosphatase; inositol 1,4,5-triphosphate 5-phosphomonoesterase; inositol triphosphate 5-phosphomonoesterase; phosphatidylinositol-bisphosphatase; phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase; phosphatidylinositol 4,5-bisphosphate phosphatase; polyphosphoinositol lipid 5-phosphatase; phosphatidyl-inositol-bisphosphate phosphatase. Cat No: EXWM-3639. |  |
| phosphoinositide phospholipase C | These enzymes form some of the cyclic phosphate Ins(cyclic1,2)P(4,5)P2 as well as Ins(1,4,5)P3. They show activity towards phosphatidylinositol, i.e., the activity of EC 4.6.1.13, phosphatidylinositol diacylglycerol-lyase, in vitro at high [Ca2+]. Four β-isoforms regulated by G-proteins, two γ-forms regulated by tyrosine kinases, four Δ-forms regulated at least in part by calcium and an ε-form, probably regulated by the oncogene ras, have been found. Group: Enzymes. Synonyms: triphosphoinositide phosphodiesterase; phosphoinositidase C; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase; monophosphatidylinositol phosphodiesterase; phosphatidylinositol phospholipase C; PI-PLC; 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase. Enzyme Commission Number: EC 3.1.4.11. CAS No. 63551-76-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3711; phosphoinositide phospholipase C; EC 3.1.4.11; 63551-76-8; triphosphoinositide phosphodiesterase; phosphoinositidase C; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase; monophosphatidylinositol phosphodiesterase; phosphatidylinositol phospholipase C; PI-PLC; 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase. Cat No: EXWM-3711. | |
| YM201636, Phosphoinositide Kinase Inhibitor (6-Amino-N- (3- (4- (4-morpholinyl) pyrido[3?2?: 4, 5]furo[3, 2-d]pyrimidin-2-yl) phenyl) -3-pyridine carboxamide) | Cell-permeable. YM-201636 is a selective inhibitor of phosphoinositide kinase (PIK) PIKfyve (IC503nM). It inhibits p110a at higher concentration (IC50=3uM). It reversibly impairs endosomal trafficking in NIH3T3 cells, mimicking the effect produced by depleting PIKfyve with siRNA. YM-201636 also blocks retroviral exit by budding from cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 371942-69-7. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| 1, 2, 3, 4-Tetrahydro-2- (trifluoroacetyl) isoquinoline-7-sulfonyl Chloride | An intermediate for the preparation of 5-heteroaryl thiazoles and their use as phosphoinositide 3-kinase (PI3K) inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 74291-57-9. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| 17β-Hydroxy wortmannin | 17β-Hydroxy wortmannin is an analog of wortmannin. It irreversibly binds phosphoinositide 3-kinase (PI3K) and potently blocks fMLP-stimulated respiratory burst in neutrophils (IC50 = 5 nM). Synonyms: 17-Hydroxy wortmannin. Grades: ≥98%. CAS No. 58053-83-1. Molecular formula: C23H26O8. Mole weight: 430.4. |  |
| 2,3-Dihydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylic Acid tert-Butyl Ester | Intermediate for the preparation of deazapurines, thienopyrimidines and furopyrimidines as phosphoinositide 3-kinase inhibitors useful in the treatment of diseases. Group: Biochemicals. Alternative Names: tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indoline-1-carboxylate; 2,3-Dihydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylic Acid 1,1-Dimethylethyl Ester. Grades: Highly Purified. CAS No. 1235451-62-3. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 2-(4-Amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-phenol | Used in the preparation of tyrosine and phosphoinositide kinase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1092787-78-4. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| 2-(5-Amino-1-tert-butyl-4-cyano)methoxyphenyl | Intermediate in the preparation of tyrosine and phosphoinositide kinase inhibitors. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 2-Aminopyrimidine-5-boronic Acid Pinacol Ester | 2-Aminopyrimidine-5-boronic Acid Pinacol Ester is used in the preparation of phosphoinositide-3-kinases (PI3K) inhibitors. Group: Biochemicals. Alternative Names: (2-Aminopyrimidin-5-yl)boronic Acid Pinacol Ester; 2-(2-Aminopyrimidin-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine-2-amine; [5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)pyrimidin-2-yl]amine. Grades: Highly Purified. CAS No. 402960-38-7. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| 2-Benzyloxy-1-bromo-4-fluorobenzene | 2-Benzyloxy-1-bromo-4-fluorobenzene is a reactant used in the synthesis of furan-2-ylmethylene thiazolidinedione derivatives as potent and selective inhibiotrs of phosphoinositide 3-kinase γ (PI3Kγ). Group: Biochemicals. Grades: Highly Purified. CAS No. 202857-88-3. Pack Sizes: 100mg, 250mg. Molecular Formula: C13H10BrFO, Molecular Weight: 281.12. US Biological Life Sciences. | Worldwide |
| 2'-Bromoacetanilide | 2'-Bromoacetanilide is used as a reagent in the preparation of furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase γ. Group: Biochemicals. Grades: Highly Purified. CAS No. 614-76-6. Pack Sizes: 1g, 5g. Molecular Formula: C8H8BrNO. US Biological Life Sciences. | Worldwide |
| 2-Methoxy-4-nitro-5-methylaniline | 2-Methoxy-4-nitro-5-methylaniline is used as a reagent to synthesize 5- and 6-methoxybenzimidazole-1,3,5-triazines, compounds that act as inhibitors of phosphoinositide 3-kinase (PI3K) that have the potential to treat cancer. Group: Biochemicals. Grades: Highly Purified. CAS No. 134-19-0. Pack Sizes: 1g, 5g. Molecular Formula: C8H10N2O3, Molecular Weight: 182.18. US Biological Life Sciences. | Worldwide |
| 3-Methoxybenzoyl Chloride | 3-Methoxybenzoyl Chloride is used in the synthesis of 2-arylbenzofuran-based molecules that act against Alzheimers disease, combatting symptoms. In addition, it aids in the optimization of di hydropyrrolopyrimidine inhibitors against PI3K (phosphoinositide 3-kinase) resulting in tumor growth inhibition. Group: Biochemicals. Alternative Names: m-Anisoyl Chloride; 3-Anisoyl Chloride; 3-Methoxybenzoic Acid Chloride; 3-Methoxybenzoyl Chloride; m-Anisoyl Chloride; m-Methoxybenzoyl Chloride. Grades: Highly Purified. CAS No. 1711-05-3. Pack Sizes: 10g. US Biological Life Sciences. | Worldwide |
| 3-Methyladenine | 3-Methyladenine is an autophagy inhibitor that protects cerebellar granule cells (CGCs) from apoptosis following serum/potassium deprivation. 3-Methyladenine inhibits phosphoinositide 3-kinase (PI3K) activity, which plays a key role in autophagy process. Synonyms: NSC 66389; NSC-66389; NSC66389; 6-Amino-3-methylpurine; 3-MA; 3H-Purin-6-amine, 3-methyl-; 3-Methyl Adenine; 3-Methyl-6-aminopurine; N3-Methyladenine. Grades: ≥98% by HPLC. CAS No. 5142-23-4. Molecular formula: C6H7N5. Mole weight: 149.15. | |
| 3-Methyl Adenosine p-Toluenesulfonate Salt | 3-Methyl Adenosine is a phosphoinositide 3-kinase inhibitor and have also been widely used as an autophagocytosis inhibitor based on their inhibitory effect on class III PI3K activity, which is essential for induction of autophagocytosis. CAS No. 72055-63-1. Molecular formula: C18H23N5O7S. Mole weight: 453.47. | |
| 4-Aminophenyl a-D-mannopyranoside 6-phosphate | 4-Aminophenyl a-D-mannopyranoside 6-phosphate is a chemical compound used in the synthesis of phosphoinositide. This product is also used in the study of phosphatidylinositol (PI) signaling pathways, and has been shown to inhibit phospholipase C activity. Additionally, it has been found to be involved in the regulation of insulin secretion. Synonyms: 4-Aminophenyl 6-phospho-alpha-mannopyranoside; 4-Aminophenyl 6-phospho-alpha-D-mannopyranoside. CAS No. 74160-60-4. Molecular formula: C12H18NO9P. Mole weight: 351.25. | |
| 4-Deoxy-4-fluoro-D-myo-inositol | 4-Deoxy-4-fluoro-D-myo-inositol is a potential inhibitor of signaling pathways mediated by phosphoinositides and their derivatives. Also it is derived from 1,2:4,5-Biscyclohexylidene DL-myo-Inositol, which is an intermediated in the synthesis of phosphonate derivatives of myo-inositol for use in biochemical studies of inositol-binding proteins. Synonyms: 4-Deoxy-4-fluoro-D-myo-inositol; 136315-50-9. CAS No. 136315-50-9. Molecular formula: C6H11FO5. Mole weight: 182.15. | |
| 6BIO | Phosphoinositide-dependent kinase 1 (PDK1) inhibitor. Potent, reversible and ATP-competitive glycogen synthase kinase-3alpha/beta (GSK-3alpha/beta) inhibitor. JAK/STAT3 signaling inhibitor. Apoptosis inducer. Potent antiproliferative agent in malignant lymphoid cell. Group: Biochemicals. Alternative Names: (2'Z,3'E)-6-Bromoindirubin-3'-oxime. Grades: Highly Purified. CAS No. 667463-62-9. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C16H10BrN3O2. US Biological Life Sciences. | Worldwide |
| Acalisib | Acalisib, also known as GS-9820, is an inhibitor of the beta and delta isoforms of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) with potential immunomodulating and antineoplastic activities. p110beta/delta PI3K inhibitor GS-9820 inhibits the activity of PI3K, thereby preventing the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), which decreases tumor cell proliferation and induces cell death. PI3K-mediated signaling is often dysregulated in cancer cells; the targeted inhibition of PI3K is designed to preserve PI3K signaling in normal, non-neoplastic cells. Synonyms: GS-9820; GS9820; GS 9820; CAL-120; CAL 120; CAL120; Acalisib; UNII-OVW60IDW1D. CAS No. 870281-34-8. Molecular formula: C21H16FN7O. Mole weight: 401.405. | |
| AS-605240 potassium salt | Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. AS-605240 inhibits human recombinant PI3Kγ, α, β, and δ in an ATP-competitive manner with IC50 values of 8, 60, 270, and 300 nM, respectively. AS-605240 also inhibits C5a-mediated phosphorylation of protein kinase B in RAW 264 cells with an IC50 value of 90 nM. AS-605240 potassium salt is the potassium salt form of AS-605240, which increase the water-solubility. Synonyms: AS-605240. Grades: ≥98%. Molecular formula: C12H6N3O2S·K. Mole weight: 295.4. | |
| AZD8186 | AZD8186 is and inhibitor of the beta isoform of phosphoinositide-3 kinase (PI3K), with potential antineoplastic activity. Upon administration, PI3Kbeta inhibitor AZD8186 selectively inhibits the activity of PI3Kbeta in the PI3K/Akt/mTOR signaling pathway, which may result in a decrease of tumor cell proliferation. It also induces cell death in PI3K-expressing cancer cells. By specifically targeting class I PI3K beta, this agent may be more efficacious and less toxic than pan PI3K inhibitors. PI3K-mediated signaling is often dysregulated in cancer cells and contributes to increased tumor cell growth, survival, and tumor resistance to a variety of antineoplastic agents. AZD8186 is currently under Phase I clinical trials. Uses: Designed for use in research and industrial production. Additional or Alternative Names: AZD8186; AZD 8186; AZD-8186. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1627494-13-6. Molecular formula: C24H25F2N3O4. Mole weight: 457.4. Purity: >98%. IUPACName: (R)-8-(1-((3,5-difluorophenyl)amino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide. Canonical SMILES: O=C(N(C)C)C1=CC([C@@H](C)NC2=CC(F)=CC(F)=C2)=C3C(C(C=C(O3)N4CCOCC4)=O)=C1. Product ID: ACM1627494136. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Bimiralisib free base | Bimiralisib, also known as PQR309, is an orally bioavailable pan inhibitor of phosphoinositide-3-kinases (PI3K) and inhibitor of the mammalian target of rapamycin (mTOR), with potential antineoplastic activity. PI3K/mTOR kinase inhibitor PQR309 inhibits the PI3K kinase isoforms alpha, beta, gamma and delta and, to a lesser extent, mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to both chemotherapy and radiotherapy. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PQR309; PQR-309; PQR309; Bimiralisib free base. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1225037-39-7. Molecular formula: C17H20F3N7O2. Mole weight: 411.39. Purity: >98%. IUPACName: 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine. Canonical SMILES: NC1=NC=C(C2=NC(N3CCOCC3)=NC(N4CCOCC4)=N2)C(C(F)(F)F)=C1. Product ID: ACM1225037397. Alfa Chemistry ISO 9001:2015 Certified. | |
| Boc-D-Glu(OMe)-OMe | A reagent used in the synthesis of amino(aminopyrimidinyl)indazoles, which are selective 3-phosphoinositide-dependent kinase-1 inhibitors and antitumor agents. Synonyms: (R)-N-Boc-glutamic acid-1,5-dimethyl ester; N-Boc-L-glutamic acid 1,5-dimethyl ester. CAS No. 130622-05-8. Molecular formula: C12H21NO6. Mole weight: 275.3. | |
| Boc-(R,S)-2-carboxymorpholine | Boc-(R,S)-2-carboxymorpholine is used in the preparation of potent and selective 3-phosphoinositide-dependent kinase 1 (PDK 1) inhibitors used in the treatment of multiple myelomas. Synonyms: Boc-(R,S)-Cop-OH; 4-Boc-2-morpholinecarboxylic acid; 4-Boc-2-morpholinecarboxylic acid; N-Boc-Morpholine-2-carboxylic acid; 4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid; 2,4-Morpholinedicarboxylicacid, 4-(1,1-dimethylethyl) ester; N-Boc-2-morpholinecarboxylic acid; (2S)-4-[(2-methylpropan-2-yl)oxycarbonyl]morpholine-2-carboxylic acid. Grades: ≥ 98 % (NMR). CAS No. 189321-66-2. Molecular formula: C10H17NO5. Mole weight: 231.25. | |
| BX-795 | 3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that phosphorylates and activates a range of other kinases, including PKB, PKA, and certain isoforms of PKC. BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, which is 140- and 1600-fold more selective than PKA and PKC. It is also a potent and relatively specific inhibitor of TBK1 with IC50 of 6 nM and IKK? with IC50 of 41 nM. Synonyms: BX 795; BX795. Grades: ≥98%. CAS No. 702675-74-9. Molecular formula: C23H26IN7O2S. Mole weight: 591.47. | |
| BX912 | BX-912 is a selective inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1) with IC50 of 12 nM; >10 fold selectivity over PKA, PKC, C-Kit, EGFR etc. Synonyms: BX912; BX 912; BX-912. Grades: 0.98. CAS No. 702674-56-4. Molecular formula: C20H23BrN8O. Mole weight: 471.363. | |
| CAL-130 | CAL-130 is a potent and selective PI3K gamma and delta inhibitor with potential anticancer activity. Constitutive phosphoinositide 3-kinase (PI3K)/Akt activation is common in T cell acute lymphoblastic leukemia (T-ALL). Although four distinct class I PI3K isoforms (α, β, γ, δ) could participate in T-ALL pathogenesis, none has been implicated in this process. In the absence of PTEN phosphatase tumor suppressor function, PI3Kγ or PI3Kδ alone can support leukemogenesis, whereas inactivation of both isoforms suppressed tumor formation. The reliance of PTEN null T-ALL on the combined activities of PI3Kγ/δ was further demonstrated by the ability of a dual inhibitor to reduce disease burden and prolong survival in mice as well as prevent proliferation and promote activation of proapoptotic pathways in human tumors. CAL-130 may be useful for therapy for T-ALL. Synonyms: CAL130; CAL 130. Grades: >98%. CAS No. 1431697-74-3. Molecular formula: C23H22N8O. Mole weight: 426.47. | |
| CAL-130 Racemate | CAL-130 racemate is a novel phosphoinositide 3-kinase (PI3K) inhibitor. It is reported that combined inhibition of PI3Kγ/δ as therapy for T cell acute lymphoblastic leukemia (T-ALL). Synonyms: CAL-130 Racemate; CAL 130 Racemate; CAL130 Racemate. Grades: >98%. CAS No. 474012-90-3. Molecular formula: C23H22N8O. Mole weight: 426.47. | |
| Copanlisib | Copanlisib is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. BAY 80-6946 inhibits the activation of the PI3K signaling pathway, which may result in the inhibition of tumor cell growth and survival in susceptible tumor cell populations. Synonyms: BAY 80-6946; Aliqopa; BAY-80-6946; 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide. Grades: ≥98%. CAS No. 1032568-63-0. Molecular formula: C23H28N8O4. Mole weight: 480.529. | |
| copanlisib hydrochloride | Copanlisib hydrochloride is a potent inhibitor of Class I phosphoinositide 3-kinase which showed a therapeutic effect on non-Hodgkin lymphoma. It was approved to treat follicular lymphoma that has relapsed after treatment with at least two other anticancer therapies. Uses: The potential treatment of non-hodgkin lymphoma. Synonyms: BAY 80-6946 dihydrochloride; BAY 80 6946 dihydrochloride; BAY 806946 dihydrochloride; Copanlisib hydrochloride; Aliqopa; Copanlisib dihydrochloride; UNII-03ZI7RZ52O; 03ZI7RZ52O; BAY 80-6946 dihydrochloride; BAY-80-6946 dihydrochloride. CAS No. 1402152-13-9. Molecular formula: C23H30Cl2N8O4. Mole weight: 553.445. | |
| CUDC-907 | CUDC-907 is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan histone deacetylase (HDAC) enzymes, with potential antineoplastic activity. Upon oral administration, CUDC-907 inhibits the activity of both PI3K class I isoforms and HDAC, thereby preventing the activation of the PI3K-AKT-mTOR signal transduction pathway that is often overactivated in many cancer cell types. This may prevent growth of PI3K and/or HDAC-expressing tumor cells. CUDC-907 shows an increased inhibition of tumor cell growth and induction of apoptosis when compared to inhibitors that target either PI3K or HDAC. Synonyms: CUDC907; CUDC 907; CUDC-907. CAS No. 1339928-25-4. Molecular formula: C23H24N8O4S. Mole weight: 508.557. | |
| CZC24832 | CZC24832 is the first selective inhibitor of phosphoinositide 3-kinase γ (PI3Kγ) with efficacy in in vitro and in vivo models of inflammation. Extensive target- and cell-based profiling of CZC24832 revealed regulation of interleukin-17-producing T helper cell (T(H)17) differentiation by PI3Kγ, thus reinforcing selective inhibition of PI3Kγ as a potential treatment for inflammatory and autoimmune diseases. Synonyms: CZC24832; CZC-24832; CZC 24832. Grades: 0.98. CAS No. 1159824-67-5. Molecular formula: C15H17FN6O2S. Mole weight: 364.399. | |
| D-myo-Inositol 1,4,5-trisphosphate tripotassium | D-myo-Inositol 1,4,5-trisphosphate tripotassium, a second messenger, elicits Ca 2+ mobilization. D-myo-Inositol 1,4,5-trisphosphate tripotassium inhibits the binding of phosphoinositide-specific phospholipase C-delta 1 (PLC-delta 1) to bilayer membranes composed of phosphatidylcholine (PC) and phosphatidylinositol 4,5-bisphosphate (PIP2) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Inositol 1,4,5-trisphosphate tripotassium; Ins(1,4,5)-P3 tripotassium. CAS No. 141611-11-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-150135B. |  |
| Duvelisib | Duvelisib, also known as IPI-145 and INK-1197, is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Upon administration, PI3K delta/gamma inhibitor IPI 145 prevents the activation of the PI3K delta/gamma-mediated signaling pathways which may lead to a reduction in cellular proliferation in PI3K delta/gamma-expressing tumor cells. Unlike other isoforms of PI3K, the delta and gamma isoforms are overexpressed primarily in hematologic malignancies and inflammatory and autoimmune diseases. By selectively targeting these PI3K isoforms, PI3K signaling in normal, non-neoplastic cells is minimally or not affected which would result in a more favorable side effect profile. Uses: For research used only. Synonyms: IPI145; IPI 145; IPI-145. INK-1197; INK 1197; INK1197; Duvelisib. CAS No. 1201438-56-3. Molecular formula: C22H17ClN6O. Mole weight: 416.869. | |
| GDC-0326 | GDC-0326 is a selective PI3Kα (α-Isoform of Phosphoinositide 3-Kinase) inhibitor. GDC-0326 is highly selective over other kinases. It has low plasma CL in human. In PI3 kinase family, there are four class I PI3K isoforms including α, β, δ, and γ and PI3Kα is the most commonly associated with cancers, so GDC-0326 may become a drug candidate for cancer treatment. Uses: Anti-cancer. Synonyms: GDC-0326; GDC 0326; GDC0326; (S)-2-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide. Grades: 98%. CAS No. 1282514-88-8. Molecular formula: C19H22N6O3. Mole weight: 382.42. | |
| GSK2334470 | GSK2334470 is a potent 3-phosphoinositide-dependent protein kinase (PDK1) inhibitor (IC50 ~ 10 nM), which does not suppress the activity of 93 other protein kinases including 13 AGC-kinases most related to PDK1 at 500-fold higher concentrations. GSK2334470 also inhibited T-loop phosphorylation and activation of Akt. GSK2334470 will be a useful tool for delineating the roles of PDK1 in biological processes. Synonyms: GSK2334470; GSK2334470; GSK2334470. Grades: 0.98. CAS No. 1227911-45-6. Molecular formula: C25H34N8O. Mole weight: 462.602. | |
| GSK2636771 | GSK2636771 is an orally bioavailable, substituted benzimidazole inhibitor of the class I phosphoinositide 3-kinase (PI3K) beta isoform with potential antineoplastic activity. PI3K beta inhibitor GSK2636771 selectively inhibits PI3K beta kinase activity in the PI3K/Akt/mTOR pathway, which may result in tumor cell apoptosis and growth inhibition in PI3K beta-expressing and/or PTEN-driven tumor cells. Dysregulation of the PI3K/Akt/mTOR pathway is frequently found in solid tumors and results in the promotion of tumor cell growth, survival, and resistance to both chemotherapy and radiotherapy. PI3K beta is the p110-beta catalytic subunit of the class I PI3K. PTEN, a tumor suppressor protein and negative regulator of PI3K activity, is often mutated in a variety of cancer cells. Uses: Antineoplastic agents. Synonyms: GSK2636771; GSK-2636771; GSK 2636771. CAS No. 1372540-25-4. Molecular formula: C22H22F3N3O3. Mole weight: 433.431. | |
| GTPγS | GTPγS is a stable G-protein-activating (GTP) analog. The physiological actions of GTPgammaS includestimulation of guanine nucleotide-binding proteins, phosphoinositide hydrolysis, cyclic AMP accumulation, and activation of specific proto-oncogenes. Synonyms: Guanosine-5'-(γ-thio)-triphosphate, Tetralithium salt; Guanosine-5'-(3-thio)-triphosphate; Guanosine-5'-(3-thiotriphosphate). Grades: ≥ 90 % by HPLC, contains < 10 % GDP. CAS No. 94825-44-2. Molecular formula: C10H16N5O13P3S (free acid). Mole weight: 539.24 (free acid). | |
| inositol-polyphosphate 5-phosphatase | One mammalian isoform is known. This enzyme is distinguished from the family of enzymes classified under EC 3.1.3.36, phosphoinositide 5-phosphatase, by its inability to dephosphorylate inositol lipids. Group: Enzymes. Synonyms: type I inositol-polyphosphate phosphatase; inositol trisphosphate phosphomonoesterase; InsP3/Ins(1,3,4,5)P4 5-phosphatase; inosine triphosphatase; D-myo-inositol 1,4,5-triphosphate 5-. Enzyme Commission Number: EC 3.1.3.56. CAS No. 106283-14-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3661; inositol-polyphosphate 5-phosphatase; EC 3.1.3.56; 106283-14-1; type I inositol-polyphosphate phosphatase; inositol trisphosphate phosphomonoesterase; InsP3/Ins(1,3,4,5)P4 5-phosphatase; inosine triphosphatase; D-myo-inositol 1,4,5-triphosphate 5-phosphatase; D-myo-inositol 1,4,5-trisphosphate 5-phosphatase; L-myo-inositol 1,4,5-trisphosphate-monoesterase; inositol phosphate 5-phosphomonoesterase; inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase; Ins(1,4,5)P3 5-phosphatase; D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase; inositol 1,4,5-trisphosphate phosphatase; inositol polyphosphate-5-phosphatase; myo-inositol-1,4,5-trisphosphate 5-phosphatase; inositol-1,4,5-trisphosphate 5-phosphatase. Cat No: EXWM-3661. | |
| Ku-0063794 | KU-0063794 is an inhibitor of both mTORC1 and mTORC2 with an IC50 of approximately 10 nM, but does not suppress the activity of 76 other protein kinases or seven lipid kinases, including Class 1 PI3Ks (phosphoinositide 3-kinases) at 1000-fold higher concentrations. KU-0063794 is cell permeant, suppresses activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK (ribosomal S6 kinase), an AGC kinase not regulated by mTOR. It also inhibited phosphorylation of the T-loop Thr308 residue of Akt phosphorylated by PDK1 (3-phosphoinositide-dependent protein kinase-1). It does not affect Thr308 phosphorylation in fibroblasts lacking essential mTORC2 subunits. KU-0063794 also suppressed cell growth and induced a G1-cell-cycle arrest. KU-0063794 will be useful in delineating the physiological roles of mTOR and may have utility in treatment of cancers in which this pathway is inappropriately activated. Uses: Differentiation. Synonyms: KU0063794; KU-0063794; KU 0063794; Ku0063794; Ku 0063794; Ku-0063794; KU63794; KU 63794; KU-63794; [5-[2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-morpholin-4-ylpyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol. Grades: 0.98. CAS No. 938440-64-3. Molecular formula: C25H31N5O4. Mole weight: 465.554. | |
| L-Quisqualic acid | L-Quisqualic acid is a glutamate receptor agonist acting at AMPA receptors and mGluR positively linked to phosphoinositide hydrolysis. L-Quisqualic acid was shown to induce a slow K(+)-current response in B6 neurons of Aplysia buccal ganglia. It exhibits neuroprotective property and may be beneficial for prostate cancer therapy. Synonyms: (L)-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid; (2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid. Grades: ≥99% by HPLC. CAS No. 52809-07-1. Molecular formula: C5H7N3O5. Mole weight: 189.13. | |
| LY294002 | LY294002 is a potent inhibitor of phosphoinositide PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively. Synonyms: LY294002; LY-294002; LY 294002; 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; 2-morpholino-8-phenyl-4H-chromen-4-one. Grades: >98%. CAS No. 154447-36-6. Molecular formula: C19H17NO3. Mole weight: 307.349. | |
| LY294002 | Potent, cell permeable, highly specific PI(3)K (phosphoinositide 3-kinase) inhibitor. Acts on the ATP-binding site of the enzyme. Antagonizes P-glycoprotein-mediated multidrug resistance. Blocks Akt phosphorylation. Pim-1 kinase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 154447-36-6. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C19H17NO3. US Biological Life Sciences. | Worldwide |
| LY 303511 | LY 303511 is an inactive analogue of the phosphoinositide 3-kinase inhibitor LY294002, but it does not inhibit PI3K. It enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells, and reversibly blocks K+ currents with an IC50 of 64.6±9.1 μM in MIN6 insulinoma cells. Synonyms: EM 101; 8-Phenyl-2-(1-piperazinyl)-4H-1-benzopyran-4-one; 2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 8-phenyl-2-(1-piperazinyl)-; 2-(1-Piperazinyl)-8-phenyl-4H-1-benzopyran-4-one; NSC736787. Grades: >98%. CAS No. 154447-38-8. Molecular formula: C19H18N2O2. Mole weight: 306.36. | |
| LY367385 | LY367385 is a highly selective and potent mGluR1a antagonist. LY367385 has an IC 50 of 8.8 μM for inhibiting of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with >100 μM for mGlu5a. LY367385 has neuroprotective, anticonvulsant and antiepileptic effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 198419-91-9. Pack Sizes: 1 mg. Product ID: HY-107515. | |
| (±)-LY367385 | (±)-LY367385 is the racemate of LY367385. LY367385 is a highly potent and selective mGluR1a antagonist. LY367385 has an IC 50 of 8.8 μM for inhibits of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with > 100 μM for mGlu5a [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 198419-90-8. Pack Sizes: 1 mg. Product ID: HY-135464. | |
| LY 367385 | LY 367385 is a selective mGlu1a receptor antagonist with an IC50 value of 8.8 μM for blockade of quisqualate-induced phosphoinositide hydrolysis. LY 367385 is used to treat inflammatory diseases and neurodegenerative diseases. Synonyms: LY367385; LY 367385; LY-367385; (S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid; 4-[(S)-Amino(carboxy)methyl]-3-methylbenzoic acid. Grades: ≥99% by HPLC. CAS No. 198419-91-9. Molecular formula: C10H11NO4. Mole weight: 209.2. | |
| LY367385 hydrochloride | LY367385 hydrochloride is a highly selective and potent mGluR1a antagonist. LY367385 hydrochloride has an IC 50 of 8.8 μM for inhibiting of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with >100 μM for mGlu5a. LY367385 hydrochloride has neuroprotective, anticonvulsant and antiepileptic effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2829282-00-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107515A. | |
| LY456236 | LY456236 is a selective, non-competitive and orally active mGlu1 receptor antagonist that inhibits phosphoinositide hydrolysis with an IC 50 of 0.145 μM. LY456236 also inhibits EGFR with an IC 50 of 0.91 μM [1] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 338736-46-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103566. | |
| MK-2461 | MK-2461 is a novel ATP-competitive multitargeted inhibitor of activated c-Met. MK-2461 inhibited in vitro phosphorylation of a peptide substrate recognized by wild-type or oncogenic c-Met kinases (N1100Y, Y1230C, Y1230H, Y1235D, and M1250T) with IC50 values of 0.4 to 2.5 nmol/L. In tumor cells, MK-2461 effectively suppressed constitutive or ligand-induced phosphorylation of the juxtamembrane domain and COOH-terminal docking site of c-Met, and its downstream signaling to the phosphoinositide 3-kinase-AKT and Ras-extracellular signal-regulated kinase pathways, without inhibiting autophosphorylation of the c-Met activation loop. In cell culture, MK-2461 inhibited hepatocyte growth factor/c-Met-dependent mitogenesis, migration, cell scatter, and tubulogenesis. In a murine xenograft model of c-Met-dependent gastric cancer, a well-tolerated oral regimen of MK-2461 administered at 100 mg/kg twice daily effectively suppressed c-Met signaling and tumor growth. Synonyms: MK 2461; MK2461; MK-2461. Grades: >98%. CAS No. 917879-39-1. Molecular formula: C24H25N5O5S. Mole weight: 495.554. | |
| MP7 | MP7 (PDK1 inhibitor) is a phosphoinositide-dependent kinase-1 ( PDK1 ) inhibitor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PDK1 inhibitor. CAS No. 1001409-50-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14440. | |
| MPEP | MPEP is a potent, selective, noncompetitive, orally active and systemically active mGlu5 receptor antagonist, with an IC 50 of 36 nM for completely inhibiting quisqualate-stimulated phosphoinositide (PI) hydrolysis. MPEP has anxiolytic-or antidepressant-like effects [1] [2]. MPEP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 96206-92-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14609A. | |
| MPEP Hydrochloride | MPEP Hydrochloride is a potent, selective, noncompetitive, orally active and systemically active mGlu5 receptor antagonist, with an IC 50 of 36 nM for completely inhibiting quisqualate-stimulated phosphoinositide (PI) hydrolysis. MPEP Hydrochloride has anxiolytic-or antidepressant-like effects [1] [2]. MPEP (Hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 219911-35-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14609. | |
| Native Escherichia coli Diacylglycerol Kinase | Diacylglycerol kinase (DGK or DAGK) is a family of enzymes that catalyzes the conversion of diacylglycerol (DAG) to phosphatidic acid (PA) utilizing ATP as a source of the phosphate. In non-stimulated cells, DGK activity is low allowing DAG to be used for glycerophospholipid biosynthesis but on receptor activation of the phosphoinositide pathway, DGK activity increases driving the conversion of DAG to PA. As both lipids are thought to function as bioactive lipid signaling molecules with distinct cellular targets, DGK therefore occupies an important position, effectively serving as a switch by terminating the signalling of one lipid while simultaneously activating signa...n of dgka and plsb genes of phospholipid synthesis by multiple stress responses in escherichia coli. diacylglycerol kinase from escherichia coli has also been used in a study to identify an alcohol binding site in the first cysteine-rich domain of protein kinase cdelta. Group: Enzymes. Synonyms: Diacylglycerol Kinase; DGK; DAGK; EC 2.7.1.107; Diacylglycerol kinase (ATP); sn-1,2-Diacylglycerol kinase. Enzyme Commission Number: EC 2.7.1.107. CAS No. 60382-71-0. DAGK. Mole weight: mol wt 13.7 kDa. Stability: -70°C. Form: suspension. Source: E. coli. Diacylglycerol Kinase; DGK; DAGK; EC 2.7.1.107; Diacylglycerol kinase (ATP); sn-1,2-Diacylglycerol kinase. Cat No: NATE-0181. | |
| PCI-32765 Racemate | PCI-32765 Racemate is a potent and highly selective inhibitor of Bruton tyrosine kinase (BTK), modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc. It is a covalent and irreversible inhibitor of BTK through bonding to Cys-481 in the ATP binding domain. It inhibits phosphorylation of BTK in a B cells as well as the downstream substrates phosphoinositide phospholipase Cγ (PLC γ) and ERK in cell assays. It has in vivo efficacy in B cell lymphoma and efficacious in autoimmune disease. It also diminished FcγRIII-induced production of pro-inflammatory cytokines. Synonyms: Ibrutinib Racemate; PCI-32765 Racemate; PCI 32765 Racemate; PCI32765 Racemate. Grades: >98%. CAS No. 936563-87-0. Molecular formula: C25H24N6O2. Mole weight: 440.5. | |
| phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase | This enzyme hydroylses 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. The enzyme also shows activity toward (PtdIns(1,3,4,5)P4). The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects. Group: Enzymes. Synonyms: SHIP1; SHIP2; SHIP; p150Ship. Enzyme Commission Number: EC 3.1.3.86. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3692; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase; EC 3.1.3.86; SHIP1; SHIP2; SHIP; p150Ship. Cat No: EXWM-3692. | |
| phosphatidylinositol-3,4-bisphosphate 4-phosphatase | Mg2+-independent. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4)P3 to Ins(1,3)P2. It also converts Ins(3,4)P2 into Ins-3-P. Group: Enzymes. Synonyms: inositol-3,4-bisphosphate 4-phosphatase; D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase; phosphoinositide 4-phosphatase; inositol polyphosphate 4-phosphatase; inositol polyphosphate 4-phosphatase type II. Enzyme Commission Number: EC 3.1.3.66. CAS No. 123644-80-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3670; phosphatidylinositol-3,4-bisphosphate 4-phosphatase; EC 3.1.3.66; 123644-80-4; inositol-3,4-bisphosphate 4-phosphatase; D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase; phosphoinositide 4-phosphatase; inositol polyphosphate 4-phosphatase; inositol polyphosphate 4-phosphatase type II. Cat No: EXWM-3670. | |
| phosphatidylinositol 3-kinase | One mammalian isoform is known. Group: Enzymes. Synonyms: 1-phosphatidylinositol 3-kinase; type III phosphoinositide 3-kinase; Vps34p; type I phosphatidylinositol kinase. Enzyme Commission Number: EC 2.7.1.137. CAS No. 115926-52-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2968; phosphatidylinositol 3-kinase; EC 2.7.1.137; 115926-52-8; 1-phosphatidylinositol 3-kinase; type III phosphoinositide 3-kinase; Vps34p; type I phosphatidylinositol kinase. Cat No: EXWM-2968. | |
| phosphatidylinositol-4,5-bisphosphate 3-kinase | This enzyme also catalyses the phosphorylation of PtdIns4P to PtdIns(3,4)P2, and of PtdIns to PtdIns3P. Four mammalian isoforms are known to exist. Group: Enzymes. Synonyms: type I phosphoinositide 3-kinase. Enzyme Commission Number: EC 2.7.1.153. CAS No. 103843-30-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2983; phosphatidylinositol-4,5-bisphosphate 3-kinase; EC 2.7.1.153; 103843-30-7; type I phosphoinositide 3-kinase. Cat No: EXWM-2983. | |
| phosphatidylinositol-4,5-bisphosphate 4-phosphatase | Two pathways exist in mammalian cells to degrade 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2]. One is catalysed by this enzyme and the other by EC 3.1.3.36, phosphoinositide 5-phosphatase, where the product is PtdIns4P. The enzyme from human is specific for PtdIns(4,5)P2 as substrate, as it cannot use PtdIns(3,4,5)P3, PtdIns(3,4)P2, PtdIns(3,5)P2, PtdIns5P, PtdIns4P or PtdIns3P. In humans, the enzyme is localized to late endosomal/lysosomal membranes. It can control nuclear levels of PtdIns5P and thereby control p53-dependent apoptosis. Group: Enzymes. Synonyms: phosphatidylinositol-4,5-bisphosphate 4-phosphatase I; phosphatidylinositol-4,5-bisphosphate 4-phosphatase II; type I PtdIns-4,5-P2 4-Ptase; type II PtdIns-4,5-P2 . Enzyme Commission Number: EC 3.1.3.78. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3683; phosphatidylinositol-4,5-bisphosphate 4-phosphatase; EC 3.1.3.78; phosphatidylinositol-4,5-bisphosphate 4-phosphatase I; phosphatidylinositol-4,5-bisphosphate 4-phosphatase II; type I PtdIns-4,5-P2 4-Ptase; type II PtdIns-4,5-P2 4-Ptase; IpgD; PtdIns-4,5-P2 4-phosphatase type I; PtdIns-4,5-P2 4-phosphatase type II; type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase; type 1 4-phosphatase. Cat No: EXWM-3683. | |
| phosphatidylinositol-4-phosphate 3-kinase | This enzyme also phosphorylates PtdIns to PtdIns3P. Three mammalian isoforms have been found to date. Group: Enzymes. Synonyms: type II phosphoinositide 3-kinase; C2-domain-containing phosphoinositide 3-kinase; phosphoinositide 3-kinase. Enzyme Commission Number: EC 2.7.1.154. CAS No. 141176-94-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2984; phosphatidylinositol-4-phosphate 3-kinase; EC 2.7.1.154; 141176-94-5; type II phosphoinositide 3-kinase; C2-domain-containing phosphoinositide 3-kinase; phosphoinositide 3-kinase. Cat No: EXWM-2984. | |
| phosphatidylinositol diacylglycerol-lyase | This enzyme is bacterial. Activity is also found in animals, but this activity is due to the presence of EC 3.1.4.11, phosphoinositide phospholipase C. Group: Enzymes. Synonyms: monophosphatidylinositol phosphodiesterase; phosphatidylinositol phospholipase C; 1-phosphatidylinositol phosphodiesterase; 1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming); 1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming). Enzyme Commission Number: EC 4.6.1.13. CAS No. 37288-19-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5350; phosphatidylinositol diacylglycerol-lyase; EC 4.6.1.13; 37288-19-0; monophosphatidylinositol phosphodiesterase; phosphatidylinositol phospholipase C; 1-phosphatidylinositol phosphodiesterase; 1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming); 1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming). Cat No: EXWM-5350. | |
| Phosphatidylinositols, soya, sodium salts | Phosphatidylinositols, soya, sodium salts is a mixture of phosphatidylinositols. Phosphoinositides are lipids involved in the vesicular transport of proteins and lipids between the different compartments of eukaryotic cells. They act by recruiting and/or activating effector proteins and thus are involved in regulating various cellular functions, such as vesicular budding, membrane fusion and cytoskeleton dynamics [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 383907-36-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-139533. | |
| PKI-179 | PKI-179 is a second generation, small-molecule mimetic of ATP that targets the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. PKI-179 selectively inhibits mTOR and phosphoinositide-3-kinase (PI3K) alpha. By inhibiting the PI3K/mTOR signaling pathway, this agent may inhibit tumor cell proliferation and survival. Synonyms: PKI-179; PKI 179; PKI179. Grades: ≥98%. CAS No. 1197160-28-3. Molecular formula: C25H28N8O3. Mole weight: 488.55. | |
| PQR309 | PQR309, a pan inhibitor of phosphoinositide-3-kinases, is still under Phase II clinical trial against Glioblastoma and Lymphoma. Uses: Pqr309 is a pan inhibitor of phosphoinositide-3-kinases and is still under phase ii clinical trial against glioblastoma and lymphoma. Synonyms: 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine; PQR309; PQR-309; PQR309; Bimiralisib free base. Grades: 98%. CAS No. 1225037-39-7. Molecular formula: C17H20F3N7O2. Mole weight: 411.38. | |
| PS 48 | PS 48 has been shown to be a PKB Kinase (phosphoinositide-dependent protein kinase-1, PDK1) activator (Kd = 10.3 μM). Studies have indicated that this compound selectively binds to the PIF-binding pocket of PKB Kinase (PDK1). This is a distinct region separate from the ATP binding site. Applications: A phosphoinositide-dependent protein kinase-1 (pdk1) activator. Group: Coenzymes. Synonyms: (Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid. CAS No. 1180676-32-7. Mole weight: 286.76. Form: Solid. (Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid; PS 48; 1180676-32-7. Cat No: COEC-117. | |
| PS 48 | PS 48 is an allosteric activator of phosphoinositide-dependent protein kinase 1 (PDPK1; PDK1) binding to the PIF-binding pocket of PDK1. Synonyms: PS-48; PS 48; PS48; (Z)-5-(4-Chlorophenyl)-3-phenylpent-2-enoic acid; (2z)-5-(4-Chlorophenyl)-3-Phenylpent-2-Enoic Acid. Grades: 99%. CAS No. 1180676-32-7. Molecular formula: C17H15ClO2. Mole weight: 286.75. | |
| RP-6530 | RP-6530, a purine derivative, has been found to be a PI3Kδ/γ inhibitor that could exhibit cytotoxicity in some lymphoma primary cells so that is significant in antineoplastic researches. It has already completed a Phase I trial for Haematological malignancies. Uses: Phosphoinositide-3 kinase inhibitors. Synonyms: RP-6530; RP6530; RP 6530; Tenalisib; (S)-2-(1-((7H-purin-6-yl)amino)propyl)-3-(3-fluorophenyl)-4H-chromen-4-one. Grades: 98%. CAS No. 1639417-53-0. Molecular formula: C23H18FN5O2. Mole weight: 415.43. | |
| S14161 | S14161 is an inhibitor of cyclins D1-D3 expression that inhibits phosphoinositide 3-kinase activity. It induces apoptosis in myeloma and leukemia cell lines with IC50 value of 10 μM. Synonyms: 8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-chromene. Grades: ≥99%. CAS No. 883046-50-2. Molecular formula: C17H14FNO4. Mole weight: 315.3. | |
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