Phosphoinositide Suppliers USA
Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
Product | Description | |
---|---|---|
Phosphoinositide 3 Kinase, p110 gamma (His) p101 (GST), Recombinant, Human (PI3K) Quick inquiry Where to buy Suppliers range | PI3K is highly expressed in cells of hematopoietic origin. It plays an important role in dendritic cell (DC) trafficking and in the activation of specific immunity. PI3K -/- mice showed a reduced ability to respond to chemokines, and had a selective defect in the number of skin Langerhans cells and in lymph node CD8alpha-DCs. In macrophages, the chemokine RANTES/CCL5 activates the small GTPase Rac1 and its downstream target PAK2. This response depends on Gi activation and largely on the subsequent triggering of PI3K. Distinct regions within the p101 regulatory subunit primary stucture are responsible for interaction with PI3K and Gbg. The PI3K binding site is confined to the N-terminus, whereas binding to Gbg is mediated by the C-terminus of p101. The PI3K catalytic subunit carries a N-terminal His6 affinity Tag, whereas the p101 adaptor subunit carries a N-terminal GST Tag. The molecular weight for p110g chain is 126.3kD (without Tag) and the p101 chain 101kD (without Tag). Group: Molecular Biology. Grades: Highly Purified. Pack Sizes: custom. US Biological Life Sciences. | Worldwide |
YM201636, Phosphoinositide Kinase Inhibitor (6-Amino-N- (3- (4- (4-morpholinyl) pyrido[3?2?: 4, 5]furo[3, 2-d]pyrimidin-2-yl) phenyl) -3-pyridine carboxamide) Quick inquiry Where to buy Suppliers range | Cell-permeable. YM-201636 is a selective inhibitor of phosphoinositide kinase (PIK) PIKfyve (IC503nM). It inhibits p110a at higher concentration (IC50=3uM). It reversibly impairs endosomal trafficking in NIH3T3 cells, mimicking the effect produced by depleting PIKfyve with siRNA. YM-201636 also blocks retroviral exit by budding from cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 371942-69-7. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
1, 2, 3, 4-Tetrahydro-2- (trifluoroacetyl) isoquinoline-7-sulfonyl Chloride Quick inquiry Where to buy Suppliers range | An intermediate for the preparation of 5-heteroaryl thiazoles and their use as phosphoinositide 3-kinase (PI3K) inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 74291-57-9. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
17β-Hydroxy wortmannin Quick inquiry Where to buy Suppliers range | 17β-Hydroxy wortmannin is an analog of wortmannin. It irreversibly binds phosphoinositide 3-kinase (PI3K) and potently blocks fMLP-stimulated respiratory burst in neutrophils (IC50 = 5 nM). Synonyms: 17-Hydroxy wortmannin. Grades: ≥98%. CAS No. 58053-83-1. Molecular formula: C23H26O8. Mole weight: 430.4. | |
2,3-Dihydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylic Acid tert-Butyl Ester Quick inquiry Where to buy Suppliers range | Intermediate for the preparation of deazapurines, thienopyrimidines and furopyrimidines as phosphoinositide 3-kinase inhibitors useful in the treatment of diseases. Group: Biochemicals. Alternative Names: tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)indoline-1-carboxylate; 2,3-Dihydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylic Acid 1,1-Dimethylethyl Ester. Grades: Highly Purified. CAS No. 1235451-62-3. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
2-(4-Amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-phenol Quick inquiry Where to buy Suppliers range | Used in the preparation of tyrosine and phosphoinositide kinase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1092787-78-4. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
2-(5-Amino-1-tert-butyl-4-cyano)methoxyphenyl Quick inquiry Where to buy Suppliers range | Intermediate in the preparation of tyrosine and phosphoinositide kinase inhibitors. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
2-Aminopyrimidine-5-boronic Acid Pinacol Ester Quick inquiry Where to buy Suppliers range | 2-Aminopyrimidine-5-boronic Acid Pinacol Ester is used in the preparation of phosphoinositide-3-kinases (PI3K) inhibitors. Group: Biochemicals. Alternative Names: (2-Aminopyrimidin-5-yl)boronic Acid Pinacol Ester; 2-(2-Aminopyrimidin-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine-2-amine; [5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)pyrimidin-2-yl]amine. Grades: Highly Purified. CAS No. 402960-38-7. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
2-Benzyloxy-1-bromo-4-fluorobenzene Quick inquiry Where to buy Suppliers range | 2-Benzyloxy-1-bromo-4-fluorobenzene is a reactant used in the synthesis of furan-2-ylmethylene thiazolidinedione derivatives as potent and selective inhibiotrs of phosphoinositide 3-kinase γ (PI3Kγ). Group: Biochemicals. Grades: Highly Purified. CAS No. 202857-88-3. Pack Sizes: 100mg, 250mg. Molecular Formula: C13H10BrFO, Molecular Weight: 281.12. US Biological Life Sciences. | Worldwide |
2'-Bromoacetanilide Quick inquiry Where to buy Suppliers range | 2'-Bromoacetanilide is used as a reagent in the preparation of furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase γ. Group: Biochemicals. Grades: Highly Purified. CAS No. 614-76-6. Pack Sizes: 1g, 5g. Molecular Formula: C8H8BrNO. US Biological Life Sciences. | Worldwide |
2-Methoxy-4-nitro-5-methylaniline Quick inquiry Where to buy Suppliers range | 2-Methoxy-4-nitro-5-methylaniline is used as a reagent to synthesize 5- and 6-methoxybenzimidazole-1,3,5-triazines, compounds that act as inhibitors of phosphoinositide 3-kinase (PI3K) that have the potential to treat cancer. Group: Biochemicals. Grades: Highly Purified. CAS No. 134-19-0. Pack Sizes: 1g, 5g. Molecular Formula: C8H10N2O3, Molecular Weight: 182.18. US Biological Life Sciences. | Worldwide |
3-Methoxybenzoyl Chloride Quick inquiry Where to buy Suppliers range | 3-Methoxybenzoyl Chloride is used in the synthesis of 2-arylbenzofuran-based molecules that act against Alzheimers disease, combatting symptoms. In addition, it aids in the optimization of di hydropyrrolopyrimidine inhibitors against PI3K (phosphoinositide 3-kinase) resulting in tumor growth inhibition. Group: Biochemicals. Alternative Names: m-Anisoyl Chloride; 3-Anisoyl Chloride; 3-Methoxybenzoic Acid Chloride; 3-Methoxybenzoyl Chloride; m-Anisoyl Chloride; m-Methoxybenzoyl Chloride. Grades: Highly Purified. CAS No. 1711-05-3. Pack Sizes: 10g. US Biological Life Sciences. | Worldwide |
3-Methyladenine Quick inquiry Where to buy Suppliers range | 3-Methyladenine is an autophagy inhibitor that protects cerebellar granule cells (CGCs) from apoptosis following serum/potassium deprivation. 3-Methyladenine inhibits phosphoinositide 3-kinase (PI3K) activity, which plays a key role in autophagy process. Synonyms: NSC 66389; NSC-66389; NSC66389; 6-Amino-3-methylpurine; 3-MA; 3H-Purin-6-amine, 3-methyl-; 3-Methyl Adenine; 3-Methyl-6-aminopurine; N3-Methyladenine. Grades: ≥98% by HPLC. CAS No. 5142-23-4. Molecular formula: C6H7N5. Mole weight: 149.15. | |
3-Methyl Adenosine p-Toluenesulfonate Salt Quick inquiry Where to buy Suppliers range | 3-Methyl Adenosine is a phosphoinositide 3-kinase inhibitor and have also been widely used as an autophagocytosis inhibitor based on their inhibitory effect on class III PI3K activity, which is essential for induction of autophagocytosis. CAS No. 72055-63-1. Molecular formula: C18H23N5O7S. Mole weight: 453.47. | |
4-Aminophenyl a-D-mannopyranoside 6-phosphate Quick inquiry Where to buy Suppliers range | 4-Aminophenyl a-D-mannopyranoside 6-phosphate is a chemical compound used in the synthesis of phosphoinositide. This product is also used in the study of phosphatidylinositol (PI) signaling pathways, and has been shown to inhibit phospholipase C activity. Additionally, it has been found to be involved in the regulation of insulin secretion. Synonyms: 4-Aminophenyl 6-phospho-alpha-mannopyranoside; 4-Aminophenyl 6-phospho-alpha-D-mannopyranoside. CAS No. 74160-60-4. Molecular formula: C12H18NO9P. Mole weight: 351.25. | |
4-Deoxy-4-fluoro-D-myo-inositol Quick inquiry Where to buy Suppliers range | 4-Deoxy-4-fluoro-D-myo-inositol is a potential inhibitor of signaling pathways mediated by phosphoinositides and their derivatives. Also it is derived from 1,2:4,5-Biscyclohexylidene DL-myo-Inositol, which is an intermediated in the synthesis of phosphonate derivatives of myo-inositol for use in biochemical studies of inositol-binding proteins. Synonyms: 4-Deoxy-4-fluoro-D-myo-inositol; 136315-50-9. CAS No. 136315-50-9. Molecular formula: C6H11FO5. Mole weight: 182.15. | |
6BIO Quick inquiry Where to buy Suppliers range | Phosphoinositide-dependent kinase 1 (PDK1) inhibitor. Potent, reversible and ATP-competitive glycogen synthase kinase-3alpha/beta (GSK-3alpha/beta) inhibitor. JAK/STAT3 signaling inhibitor. Apoptosis inducer. Potent antiproliferative agent in malignant lymphoid cell. Group: Biochemicals. Alternative Names: (2'Z,3'E)-6-Bromoindirubin-3'-oxime. Grades: Highly Purified. CAS No. 667463-62-9. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C16H10BrN3O2. US Biological Life Sciences. | Worldwide |
Acalisib Quick inquiry Where to buy Suppliers range | Acalisib, also known as GS-9820, is an inhibitor of the beta and delta isoforms of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) with potential immunomodulating and antineoplastic activities. p110beta/delta PI3K inhibitor GS-9820 inhibits the activity of PI3K, thereby preventing the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), which decreases tumor cell proliferation and induces cell death. PI3K-mediated signaling is often dysregulated in cancer cells; the targeted inhibition of PI3K is designed to preserve PI3K signaling in normal, non-neoplastic cells. Synonyms: GS-9820; GS9820; GS 9820; CAL-120; CAL 120; CAL120; Acalisib; UNII-OVW60IDW1D. CAS No. 870281-34-8. Molecular formula: C21H16FN7O. Mole weight: 401.405. | |
AS-605240 potassium salt Quick inquiry Where to buy Suppliers range | Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. AS-605240 inhibits human recombinant PI3Kγ, α, β, and δ in an ATP-competitive manner with IC50 values of 8, 60, 270, and 300 nM, respectively. AS-605240 also inhibits C5a-mediated phosphorylation of protein kinase B in RAW 264 cells with an IC50 value of 90 nM. AS-605240 potassium salt is the potassium salt form of AS-605240, which increase the water-solubility. Synonyms: AS-605240. Grades: ≥98%. Molecular formula: C12H6N3O2S·K. Mole weight: 295.4. | |
Boc-D-Glu(OMe)-OMe Quick inquiry Where to buy Suppliers range | A reagent used in the synthesis of amino(aminopyrimidinyl)indazoles, which are selective 3-phosphoinositide-dependent kinase-1 inhibitors and antitumor agents. Synonyms: (R)-N-Boc-glutamic acid-1,5-dimethyl ester; N-Boc-L-glutamic acid 1,5-dimethyl ester. CAS No. 130622-05-8. Molecular formula: C12H21NO6. Mole weight: 275.3. | |
Boc-(R,S)-2-carboxymorpholine Quick inquiry Where to buy Suppliers range | Boc-(R,S)-2-carboxymorpholine is used in the preparation of potent and selective 3-phosphoinositide-dependent kinase 1 (PDK 1) inhibitors used in the treatment of multiple myelomas. Synonyms: Boc-(R,S)-Cop-OH; 4-Boc-2-morpholinecarboxylic acid; 4-Boc-2-morpholinecarboxylic acid; N-Boc-Morpholine-2-carboxylic acid; 4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid; 2,4-Morpholinedicarboxylicacid, 4-(1,1-dimethylethyl) ester; N-Boc-2-morpholinecarboxylic acid; (2S)-4-[(2-methylpropan-2-yl)oxycarbonyl]morpholine-2-carboxylic acid. Grades: ≥ 98 % (NMR). CAS No. 189321-66-2. Molecular formula: C10H17NO5. Mole weight: 231.25. | |
BX-795 Quick inquiry Where to buy Suppliers range | 3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that phosphorylates and activates a range of other kinases, including PKB, PKA, and certain isoforms of PKC. BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, which is 140- and 1600-fold more selective than PKA and PKC. It is also a potent and relatively specific inhibitor of TBK1 with IC50 of 6 nM and IKK? with IC50 of 41 nM. Synonyms: BX 795; BX795. Grades: ≥98%. CAS No. 702675-74-9. Molecular formula: C23H26IN7O2S. Mole weight: 591.47. | |
BX912 Quick inquiry Where to buy Suppliers range | BX-912 is a selective inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1) with IC50 of 12 nM; >10 fold selectivity over PKA, PKC, C-Kit, EGFR etc. Synonyms: BX912; BX 912; BX-912. Grades: 0.98. CAS No. 702674-56-4. Molecular formula: C20H23BrN8O. Mole weight: 471.363. | |
CAL-130 Quick inquiry Where to buy Suppliers range | CAL-130 is a potent and selective PI3K gamma and delta inhibitor with potential anticancer activity. Constitutive phosphoinositide 3-kinase (PI3K)/Akt activation is common in T cell acute lymphoblastic leukemia (T-ALL). Although four distinct class I PI3K isoforms (α, β, γ, δ) could participate in T-ALL pathogenesis, none has been implicated in this process. In the absence of PTEN phosphatase tumor suppressor function, PI3Kγ or PI3Kδ alone can support leukemogenesis, whereas inactivation of both isoforms suppressed tumor formation. The reliance of PTEN null T-ALL on the combined activities of PI3Kγ/δ was further demonstrated by the ability of a dual inhibitor to reduce disease burden and prolong survival in mice as well as prevent proliferation and promote activation of proapoptotic pathways in human tumors. CAL-130 may be useful for therapy for T-ALL. Synonyms: CAL130; CAL 130. Grades: >98%. CAS No. 1431697-74-3. Molecular formula: C23H22N8O. Mole weight: 426.47. | |
CAL-130 Racemate Quick inquiry Where to buy Suppliers range | CAL-130 racemate is a novel phosphoinositide 3-kinase (PI3K) inhibitor. It is reported that combined inhibition of PI3Kγ/δ as therapy for T cell acute lymphoblastic leukemia (T-ALL). Synonyms: CAL-130 Racemate; CAL 130 Racemate; CAL130 Racemate. Grades: >98%. CAS No. 474012-90-3. Molecular formula: C23H22N8O. Mole weight: 426.47. | |
Copanlisib Quick inquiry Where to buy Suppliers range | Copanlisib is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. BAY 80-6946 inhibits the activation of the PI3K signaling pathway, which may result in the inhibition of tumor cell growth and survival in susceptible tumor cell populations. Synonyms: BAY 80-6946; Aliqopa; BAY-80-6946; 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide. Grades: ≥98%. CAS No. 1032568-63-0. Molecular formula: C23H28N8O4. Mole weight: 480.529. | |
copanlisib hydrochloride Quick inquiry Where to buy Suppliers range | Copanlisib hydrochloride is a potent inhibitor of Class I phosphoinositide 3-kinase which showed a therapeutic effect on non-Hodgkin lymphoma. It was approved to treat follicular lymphoma that has relapsed after treatment with at least two other anticancer therapies. Uses: The potential treatment of non-hodgkin lymphoma. Synonyms: BAY 80-6946 dihydrochloride; BAY 80 6946 dihydrochloride; BAY 806946 dihydrochloride; Copanlisib hydrochloride; Aliqopa; Copanlisib dihydrochloride; UNII-03ZI7RZ52O; 03ZI7RZ52O; BAY 80-6946 dihydrochloride; BAY-80-6946 dihydrochloride. CAS No. 1402152-13-9. Molecular formula: C23H30Cl2N8O4. Mole weight: 553.445. | |
CUDC-907 Quick inquiry Where to buy Suppliers range | CUDC-907 is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan histone deacetylase (HDAC) enzymes, with potential antineoplastic activity. Upon oral administration, CUDC-907 inhibits the activity of both PI3K class I isoforms and HDAC, thereby preventing the activation of the PI3K-AKT-mTOR signal transduction pathway that is often overactivated in many cancer cell types. This may prevent growth of PI3K and/or HDAC-expressing tumor cells. CUDC-907 shows an increased inhibition of tumor cell growth and induction of apoptosis when compared to inhibitors that target either PI3K or HDAC. Synonyms: CUDC907; CUDC 907; CUDC-907. CAS No. 1339928-25-4. Molecular formula: C23H24N8O4S. Mole weight: 508.557. | |
CZC24832 Quick inquiry Where to buy Suppliers range | CZC24832 is the first selective inhibitor of phosphoinositide 3-kinase γ (PI3Kγ) with efficacy in in vitro and in vivo models of inflammation. Extensive target- and cell-based profiling of CZC24832 revealed regulation of interleukin-17-producing T helper cell (T(H)17) differentiation by PI3Kγ, thus reinforcing selective inhibition of PI3Kγ as a potential treatment for inflammatory and autoimmune diseases. Synonyms: CZC24832; CZC-24832; CZC 24832. Grades: 0.98. CAS No. 1159824-67-5. Molecular formula: C15H17FN6O2S. Mole weight: 364.399. | |
Duvelisib Quick inquiry Where to buy Suppliers range | Duvelisib, also known as IPI-145 and INK-1197, is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Upon administration, PI3K delta/gamma inhibitor IPI 145 prevents the activation of the PI3K delta/gamma-mediated signaling pathways which may lead to a reduction in cellular proliferation in PI3K delta/gamma-expressing tumor cells. Unlike other isoforms of PI3K, the delta and gamma isoforms are overexpressed primarily in hematologic malignancies and inflammatory and autoimmune diseases. By selectively targeting these PI3K isoforms, PI3K signaling in normal, non-neoplastic cells is minimally or not affected which would result in a more favorable side effect profile. Uses: For research used only. Synonyms: IPI145; IPI 145; IPI-145. INK-1197; INK 1197; INK1197; Duvelisib. CAS No. 1201438-56-3. Molecular formula: C22H17ClN6O. Mole weight: 416.869. | |
GDC-0326 Quick inquiry Where to buy Suppliers range | GDC-0326 is a selective PI3Kα (α-Isoform of Phosphoinositide 3-Kinase) inhibitor. GDC-0326 is highly selective over other kinases. It has low plasma CL in human. In PI3 kinase family, there are four class I PI3K isoforms including α, β, δ, and γ and PI3Kα is the most commonly associated with cancers, so GDC-0326 may become a drug candidate for cancer treatment. Uses: Anti-cancer. Synonyms: GDC-0326; GDC 0326; GDC0326; (S)-2-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide. Grades: 98%. CAS No. 1282514-88-8. Molecular formula: C19H22N6O3. Mole weight: 382.42. | |
GSK2334470 Quick inquiry Where to buy Suppliers range | GSK2334470 is a potent 3-phosphoinositide-dependent protein kinase (PDK1) inhibitor (IC50 ~ 10 nM), which does not suppress the activity of 93 other protein kinases including 13 AGC-kinases most related to PDK1 at 500-fold higher concentrations. GSK2334470 also inhibited T-loop phosphorylation and activation of Akt. GSK2334470 will be a useful tool for delineating the roles of PDK1 in biological processes. Synonyms: GSK2334470; GSK2334470; GSK2334470. Grades: 0.98. CAS No. 1227911-45-6. Molecular formula: C25H34N8O. Mole weight: 462.602. | |
GSK2636771 Quick inquiry Where to buy Suppliers range | GSK2636771 is an orally bioavailable, substituted benzimidazole inhibitor of the class I phosphoinositide 3-kinase (PI3K) beta isoform with potential antineoplastic activity. PI3K beta inhibitor GSK2636771 selectively inhibits PI3K beta kinase activity in the PI3K/Akt/mTOR pathway, which may result in tumor cell apoptosis and growth inhibition in PI3K beta-expressing and/or PTEN-driven tumor cells. Dysregulation of the PI3K/Akt/mTOR pathway is frequently found in solid tumors and results in the promotion of tumor cell growth, survival, and resistance to both chemotherapy and radiotherapy. PI3K beta is the p110-beta catalytic subunit of the class I PI3K. PTEN, a tumor suppressor protein and negative regulator of PI3K activity, is often mutated in a variety of cancer cells. Uses: Antineoplastic agents. Synonyms: GSK2636771; GSK-2636771; GSK 2636771. CAS No. 1372540-25-4. Molecular formula: C22H22F3N3O3. Mole weight: 433.431. | |
GTPγS Quick inquiry Where to buy Suppliers range | GTPγS is a stable G-protein-activating (GTP) analog. The physiological actions of GTPgammaS includestimulation of guanine nucleotide-binding proteins, phosphoinositide hydrolysis, cyclic AMP accumulation, and activation of specific proto-oncogenes. Synonyms: Guanosine-5'-(γ-thio)-triphosphate, Tetralithium salt; Guanosine-5'-(3-thio)-triphosphate; Guanosine-5'-(3-thiotriphosphate). Grades: ≥ 90 % by HPLC, contains < 10 % GDP. CAS No. 94825-44-2. Molecular formula: C10H16N5O13P3S (free acid). Mole weight: 539.24 (free acid). | |
Ku-0063794 Quick inquiry Where to buy Suppliers range | KU-0063794 is an inhibitor of both mTORC1 and mTORC2 with an IC50 of approximately 10 nM, but does not suppress the activity of 76 other protein kinases or seven lipid kinases, including Class 1 PI3Ks (phosphoinositide 3-kinases) at 1000-fold higher concentrations. KU-0063794 is cell permeant, suppresses activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK (ribosomal S6 kinase), an AGC kinase not regulated by mTOR. It also inhibited phosphorylation of the T-loop Thr308 residue of Akt phosphorylated by PDK1 (3-phosphoinositide-dependent protein kinase-1). It does not affect Thr308 phosphorylation in fibroblasts lacking essential mTORC2 subunits. KU-0063794 also suppressed cell growth and induced a G1-cell-cycle arrest. KU-0063794 will be useful in delineating the physiological roles of mTOR and may have utility in treatment of cancers in which this pathway is inappropriately activated. Uses: Differentiation. Synonyms: KU0063794; KU-0063794; KU 0063794; Ku0063794; Ku 0063794; Ku-0063794; KU63794; KU 63794; KU-63794; [5-[2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-morpholin-4-ylpyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol. Grades: 0.98. CAS No. 938440-64-3. Molecular formula: C25H31N5O4. Mole weight: 465.554. | |
L-Quisqualic acid Quick inquiry Where to buy Suppliers range | L-Quisqualic acid is a glutamate receptor agonist acting at AMPA receptors and mGluR positively linked to phosphoinositide hydrolysis. L-Quisqualic acid was shown to induce a slow K(+)-current response in B6 neurons of Aplysia buccal ganglia. It exhibits neuroprotective property and may be beneficial for prostate cancer therapy. Synonyms: (L)-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid; (2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid. Grades: ≥99% by HPLC. CAS No. 52809-07-1. Molecular formula: C5H7N3O5. Mole weight: 189.13. | |
LY294002 Quick inquiry Where to buy Suppliers range | LY294002 is a potent inhibitor of phosphoinositide PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively. Synonyms: LY294002; LY-294002; LY 294002; 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; 2-morpholino-8-phenyl-4H-chromen-4-one. Grades: >98%. CAS No. 154447-36-6. Molecular formula: C19H17NO3. Mole weight: 307.349. | |
LY294002 Quick inquiry Where to buy Suppliers range | Potent, cell permeable, highly specific PI(3)K (phosphoinositide 3-kinase) inhibitor. Acts on the ATP-binding site of the enzyme. Antagonizes P-glycoprotein-mediated multidrug resistance. Blocks Akt phosphorylation. Pim-1 kinase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 154447-36-6. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C19H17NO3. US Biological Life Sciences. | Worldwide |
LY 303511 Quick inquiry Where to buy Suppliers range | LY 303511 is an inactive analogue of the phosphoinositide 3-kinase inhibitor LY294002, but it does not inhibit PI3K. It enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells, and reversibly blocks K+ currents with an IC50 of 64.6±9.1 μM in MIN6 insulinoma cells. Synonyms: EM 101; 8-Phenyl-2-(1-piperazinyl)-4H-1-benzopyran-4-one; 2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 8-phenyl-2-(1-piperazinyl)-; 2-(1-Piperazinyl)-8-phenyl-4H-1-benzopyran-4-one; NSC736787. Grades: >98%. CAS No. 154447-38-8. Molecular formula: C19H18N2O2. Mole weight: 306.36. | |
LY 367385 Quick inquiry Where to buy Suppliers range | LY 367385 is a selective mGlu1a receptor antagonist with an IC50 value of 8.8 μM for blockade of quisqualate-induced phosphoinositide hydrolysis. LY 367385 is used to treat inflammatory diseases and neurodegenerative diseases. Synonyms: LY367385; LY 367385; LY-367385; (S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid; 4-[(S)-Amino(carboxy)methyl]-3-methylbenzoic acid. Grades: ≥99% by HPLC. CAS No. 198419-91-9. Molecular formula: C10H11NO4. Mole weight: 209.2. | |
MK-2461 Quick inquiry Where to buy Suppliers range | MK-2461 is a novel ATP-competitive multitargeted inhibitor of activated c-Met. MK-2461 inhibited in vitro phosphorylation of a peptide substrate recognized by wild-type or oncogenic c-Met kinases (N1100Y, Y1230C, Y1230H, Y1235D, and M1250T) with IC50 values of 0.4 to 2.5 nmol/L. In tumor cells, MK-2461 effectively suppressed constitutive or ligand-induced phosphorylation of the juxtamembrane domain and COOH-terminal docking site of c-Met, and its downstream signaling to the phosphoinositide 3-kinase-AKT and Ras-extracellular signal-regulated kinase pathways, without inhibiting autophosphorylation of the c-Met activation loop. In cell culture, MK-2461 inhibited hepatocyte growth factor/c-Met-dependent mitogenesis, migration, cell scatter, and tubulogenesis. In a murine xenograft model of c-Met-dependent gastric cancer, a well-tolerated oral regimen of MK-2461 administered at 100 mg/kg twice daily effectively suppressed c-Met signaling and tumor growth. Synonyms: MK 2461; MK2461; MK-2461. Grades: >98%. CAS No. 917879-39-1. Molecular formula: C24H25N5O5S. Mole weight: 495.554. | |
PCI-32765 Racemate Quick inquiry Where to buy Suppliers range | PCI-32765 Racemate is a potent and highly selective inhibitor of Bruton tyrosine kinase (BTK), modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc. It is a covalent and irreversible inhibitor of BTK through bonding to Cys-481 in the ATP binding domain. It inhibits phosphorylation of BTK in a B cells as well as the downstream substrates phosphoinositide phospholipase Cγ (PLC γ) and ERK in cell assays. It has in vivo efficacy in B cell lymphoma and efficacious in autoimmune disease. It also diminished FcγRIII-induced production of pro-inflammatory cytokines. Synonyms: Ibrutinib Racemate; PCI-32765 Racemate; PCI 32765 Racemate; PCI32765 Racemate. Grades: >98%. CAS No. 936563-87-0. Molecular formula: C25H24N6O2. Mole weight: 440.5. | |
PKI-179 Quick inquiry Where to buy Suppliers range | PKI-179 is a second generation, small-molecule mimetic of ATP that targets the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. PKI-179 selectively inhibits mTOR and phosphoinositide-3-kinase (PI3K) alpha. By inhibiting the PI3K/mTOR signaling pathway, this agent may inhibit tumor cell proliferation and survival. Synonyms: PKI-179; PKI 179; PKI179. Grades: ≥98%. CAS No. 1197160-28-3. Molecular formula: C25H28N8O3. Mole weight: 488.55. | |
PQR309 Quick inquiry Where to buy Suppliers range | PQR309, a pan inhibitor of phosphoinositide-3-kinases, is still under Phase II clinical trial against Glioblastoma and Lymphoma. Uses: Pqr309 is a pan inhibitor of phosphoinositide-3-kinases and is still under phase ii clinical trial against glioblastoma and lymphoma. Synonyms: 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine; PQR309; PQR-309; PQR309; Bimiralisib free base. Grades: 98%. CAS No. 1225037-39-7. Molecular formula: C17H20F3N7O2. Mole weight: 411.38. | |
PS 48 Quick inquiry Where to buy Suppliers range | PS 48 is an allosteric activator of phosphoinositide-dependent protein kinase 1 (PDPK1; PDK1) binding to the PIF-binding pocket of PDK1. Synonyms: PS-48; PS 48; PS48; (Z)-5-(4-Chlorophenyl)-3-phenylpent-2-enoic acid; (2z)-5-(4-Chlorophenyl)-3-Phenylpent-2-Enoic Acid. Grades: 99%. CAS No. 1180676-32-7. Molecular formula: C17H15ClO2. Mole weight: 286.75. | |
RP-6530 Quick inquiry Where to buy Suppliers range | RP-6530, a purine derivative, has been found to be a PI3Kδ/γ inhibitor that could exhibit cytotoxicity in some lymphoma primary cells so that is significant in antineoplastic researches. It has already completed a Phase I trial for Haematological malignancies. Uses: Phosphoinositide-3 kinase inhibitors. Synonyms: RP-6530; RP6530; RP 6530; Tenalisib; (S)-2-(1-((7H-purin-6-yl)amino)propyl)-3-(3-fluorophenyl)-4H-chromen-4-one. Grades: 98%. CAS No. 1639417-53-0. Molecular formula: C23H18FN5O2. Mole weight: 415.43. | |
S14161 Quick inquiry Where to buy Suppliers range | S14161 is an inhibitor of cyclins D1-D3 expression that inhibits phosphoinositide 3-kinase activity. It induces apoptosis in myeloma and leukemia cell lines with IC50 value of 10 μM. Synonyms: 8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-chromene. Grades: ≥99%. CAS No. 883046-50-2. Molecular formula: C17H14FNO4. Mole weight: 315.3. | |
SAR-405 Quick inquiry Where to buy Suppliers range | SAR-405 is a potent and selective inhibitor of phosphoinositide 3-kinase (PI3K) class III isoform Vps34 (IC50 = 1.2 nM, Kd=1.5 nM) without disrupting other PI3K isoforms and mTOR (IC50 > 10,000 nM). Concomitant inhibition of Vps34 and mTOR, with SAR405 and mTOR inhibitor everolimus, results in synergistic antiproliferative activity in renal tumor cell lines. Synonyms: SAR 405; SAR405; 4H-Pyrimido[1,?2-a]?pyrimidin-4-one, 9-[(5-chloro-3-pyridinyl)?methyl]?-6,?7,?8,?9-tetrahydro-2-[(3R)?-3-methyl-4-morpholinyl]?-8-(trifluoromethyl)?-, (8S)?-; (8S)-9-[(5-Chloro-3-pyridinyl)methyl]-6,7,8,9-tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-8-(trifluoromethyl)-4H-pyrimido[1,2-a]pyrimidin-4-one. CAS No. 1523406-39-4. Molecular formula: C19H21ClF3N5O2. Mole weight: 443.85. | |
SF1126 Quick inquiry Where to buy Suppliers range | SF1126 is a water soluble, small-molecule prodrug containing the pan-PI3K/mTOR inhibitor LY294002/SF1101 conjugated to the RGD-containing tetra-peptide SF1174 with potential antineoplastic and antiangiogenic activities. The targeting peptide SF1174 moiety of pan-PI3K/mTOR inhibitor SF1126 selectively binds to cell surface integrins and, upon cell entry, the agent is hydrolyzed to the active drug SF1101; SF1101 selectively inhibits all isoforms of phosphoinositide-3-kinase (PI3K) and other members of the PI3K superfamily, such as the mammalian target of rapamycin (mTOR) and DNA-PK. By inhibiting the PI3K signaling pathway, this agent may inhibit tumor cell and tumor endothelial cell proliferation and survival. Integrins are transmembrane cell adhesion proteins expressed on the surfaces of endothelial and tumor cells. Synonyms: SF 1126, SF-1126. CAS No. 936487-67-1. Molecular formula: C39H48N8O14. Mole weight: 852.84. | |
Sitaxentan sodium Quick inquiry Where to buy Suppliers range | Sitaxentan sodium inhibits ET-1-induced stimulation of phosphoinositide turnover with a Ki of 0.69 nM and a pA2 of 8.0. Synonyms: TBC-11251; TBC 11251; TBC11251. Grades: >98%. CAS No. 210421-74-2. Molecular formula: C18H14ClN2O6S2.Na. Mole weight: 476.89. | |
SKF 83822 hydrobromide Quick inquiry Where to buy Suppliers range | SKF 83822 hydrobromide is a selective and high affinity dopamine D1-like receptor agonist (Ki = 3.2, 3.1, 186, 66, 335, 1167, 1251 and 1385 nM at recombinant D1, D5, D2, D3, D4, 5-HT2A, α1A and α1B receptors, respectively). SKF 83822 stimulates adenylyl cyclase (EC50 = 65 nM) but not phosphoinositide hydrolysis. Synonyms: SKF 83822 hydrobromide; SKF83822 hydrobromide; SKF-83822 hydrobromide; 6-Chloro-2,3,4,5-tetrahydro-1-(3-methylphenyl)-3-(2-propenyl)-1H-3-benzazepine-7,8-diol hydrobromide; 9-chloro-5-(3-methylphenyl)-3-prop-2-enyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol hydrobromide. Grades: ≥98% by HPLC. CAS No. 74115-10-9. Molecular formula: C20H22ClNO2.HBr. Mole weight: 424.76. | |
SMI 481 Quick inquiry Where to buy Suppliers range | SMI 481 is a small-molecule inhibitor (SMI) of the yeast phosphatidylinositol transfer proteins (PITP) Sec14 (IC50 values of 211 nM and 2.87 μM for Sec14 mediated [3H]PtdIns transfer in vitro, and Sec14 dependent cell growth inhibition of WT (CTY182, gray) strains, respectively). SMI 481 exhibits exquisite pathway selectivity in inhibiting phosphoinositide signaling in cells with >200-fold selectivity over other yeast Sec14-like transfer activities. Synonyms: SMI481; SMI-481 SMI 481; NPPM 6748-481; NPPM 6748481; NPPM6748481; NPPM-6748-481; (4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)methanone; 1-(4-chloro-3-nitrobenzoyl)-4-(2-fluorophenyl)piperazine; (4-chloro-3-nitrophenyl)[4-(2-fluorophenyl)piperazin-1-yl]methanone. Grades: 99%. CAS No. 432020-20-7. Molecular formula: C17H15ClFN3O3. Mole weight: 363.77. | |
Sonolisib Quick inquiry Where to buy Suppliers range | Sonolisib, also known as PX-866, is a small-molecule wortmannin analogue inhibitor of the alpha, gamma, and delta isoforms of phosphoinositide 3-kinase (PI3K) with potential antineoplastic activity. PI3K inhibitor PX-866 inhibits the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway, which may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. Uses: Potential anti-cancer agent. Synonyms: PX-866; PX866; PX 866. Grades: >98%. CAS No. 502632-66-8. Molecular formula: C29H35NO8. Mole weight: 525.59. | |
Tricirbine Quick inquiry Where to buy Suppliers range | Triciribine is a potent AKT inhibitor and a cell-permeable tricyclic nucleoside molecule with potential antineoplastic activity. Akt-1, -2, and -3 are serine/threonine protein kinases in the phosphatidylinositol (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival. Following recruitment of Akt to the plasma membrane, phosphorylation at threonine 308 and serine 473 (Akt-1 numbering) by phosphoinositide-dependent kinases (PDK) 1 and 2 results in full activation of the enzyme. Triciribine is a cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3. It does not inhibit phosphatidylinositol 3 (PI3)-Kinase or PDK1, the direct upstream activators of Akt, nor does it inhibit PKC, PKA, ERK1/2, serum- and glucocorticoid-inducible kinase, p38, STAT3, or JNK signalling pathways. Triciribine effectively inhibits growth of Akt-overexpressing human cancer cell lines in vitro with 50% inhibition at ~5-10 μM. It also inhibit growth of tumor xenografts in mice by greater than 80% at a dose of 1 mg/kg/day. Synonyms: VQD-002; VQD 002; VQD002; NSC-154020; NSC 154020; NSC154020; Triciribine; TCN-P; triciribine; Tricyclic nucleoside; Pentaazacentopthylene; API-2; Akt Inhibitor V. Grades: 99.81%. CAS No. 35943-35-2. Molecular formula: C13H16N6O4. Mole weight: 320.309. | |
U-73122 Quick inquiry Where to buy Suppliers range | U-73122 is a phospholipase C inhibitor originated by Pharmacia Corporation and IC 50 value is 1.0-2.1 μM in neutrophils and human platelets. U-73122 can be used as a tool to investigate the involvement of the PLC (phosphoinositide-specific phospholipase C) in signal transduction, especially in reseraches trying to characterize pathways leading to intracellular Ca2+ mobilization upon agonist challenge. Preclinical trials for treatment of Thrombosis was discontinued in 1998. Uses: Thrombosis. Synonyms: U-73122; U 73122; U73122; 1-(6-(((8R,9S,13S,14S,17S)-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione. Grades: 95%. CAS No. 112648-68-7. Molecular formula: C29H40N2O3. Mole weight: 464.64. | |
VPS34 inhibitor 1 Quick inquiry Where to buy Suppliers range | VPS34 inhibitor 1 is a potent and selective inhibitor of VPS34 (IC50 = 15 nM). Vps34 is a phosphoinositide 3-kinase (PI3K) class III isoform that has attracted major attention over the recent years because of its role in autophagy. VPS34 inhibitors can be used to investigate autophagy, a degradation process that recycles cellular components. Synonyms: 1-[[4-(cyclopropylmethyl)-5-[2-(pyridin-4-ylamino)pyrimidin-4-yl]pyrimidin-2-yl]amino]-2-methylpropan-2-ol; Compound 19, PIK-III analogue; Compound 19, PIK-III analogue. Grades: 99.27 %. CAS No. 1383716-46-8. Molecular formula: C21H25N7O. Mole weight: 391.47. | |
Wortmannin Quick inquiry Where to buy Suppliers range | It is an antibiotic produced by the strain of Pen. wortmanni 989. It has strong antifungal effect. It is a specific covalent inhibitor of phosphoinositide 3-kinases (PI3Ks) and Polo-Like kinase 1 (PLK1). It is a commonly used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation. Uses: Immunosuppressive agents. Synonyms: Antibiotic SL-2052; (1alpha,11alpha)-11-(Acetyloxy)-1-(methoxymethyl)-2-oxaandrosta-5,8-dieno(6,5,4-bc)furan-3,7,17-trione; (1S,6bR,9aS,11R,11bR)-1-(Methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate. Grades: 98%. CAS No. 19545-26-7. Molecular formula: C23H24O8. Mole weight: 428.43. | |
WP1066 ((2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethy]-2-propenamide) Quick inquiry Where to buy Suppliers range | A potent, cell-permeable JAK2 inhibitor. A novel analog of the JAK2 inhibitor AG490 that blocks STAT3 and phosphoinositide-3-kinase pathways. It is significantly more potent and active against human malignant glioma cells in vitro and in vivo than AG 490. Similar to AG490, WP1066 inhibits the phosphorylation of JAK2, but unlike AG490, WP1066 also degrades JAK2 protein, thus blocking its downstream signal transducer and activator of transcription (STAT) and phosphoinositide-3-kinase pathways to results in the activation of the caspase pathway. Group: Biochemicals. Grades: Purified. CAS No. 857064-38-1. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
ZSTK474 Quick inquiry Where to buy Suppliers range | ZSTK474 is a novel phosphatidylinositol 3-kinase (PI3K) inhibitor, which strongly inhibits cancer cell proliferation. Phosphoinositide 3-kinase (PI3K) is a potential target in cancer therapy. Inhibition of PI3K is believed to induce apoptosis. ZSTK474 effectively inhibited the growth of human cancer xenografts in vivo. ZSTK474 treatment suppressed the expression of nuclear cyclin D1 and Ki67 and also the expression of phospho-Akt, both of which are hallmarks of proliferation. We demonstrate that ZSTK474 induces G1arrest along with tumour suppression. Moreover, ZSTK474 suppresses the tumour growth without inducing apoptosis. Interestingly, long-term (3-month) administration of ZSTK474 maintained such increase in G1 cells and tumour suppression. ZSTK474 exerts its in vivo antitumour efficacy via G1 arrest but not via apoptosis as long as it is administered. Synonyms: ZSTK474; ZSTK-474; ZSTK 474. Grades: 0.99. CAS No. 475110-96-4. Molecular formula: C19H21F2N7O2. Mole weight: 417.421. |