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| Product | Description | |
|---|---|---|
| Heat Shock Factor 1 Inhibitor, KRIBB11 (N2-(1H-Indazol-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine , HSF1 Inhibitor, KRIBB11, Heat Shock Protein Inhibitor III, p-TEFb hsp70 Promoter Recruitment Inhibitor, Hsp70 Induction Inhibitor II) | A cell-permeable 2,6-diaminopyridine compound that directly binds HSF1 and reversibly inhibits its transcriptional activity (IC50=1.2uM in heat shocked p[HSE]4-Ta-Luc transfected HCT-116 cells), and suppresses both the transcription and expression of hsp70, hsp47 and hsp27. Shown to block heat shock-induced p-TEFb (positive transcription elongation factor b) recruitment to the hsp70 promoter and inhibit the phosphorylation of RNA Pol II CTD-Ser2 with no effect on TNF-a-stimulated NF-kB activity in HeLa cells. Induces G2/M growth arrest and apoptosis (IC50 ~5uM in HCT-116 cells), and further decreases tumor growth in mouse xenograft regression model (50mg/kg, i.p.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Mitochondrial Fusion Promoter, M1 ( (E) -4-Chloro-2- (1- (2- (2, 4, 6-trichlorophenyl) hydrazono) ethyl) phenol) | A cell-permeable phenylhydrazone that restores mitochondrial tubular network formation in MEF lacking either of the two outer mitochondrial membrane (OMM) mitofusins (EC50=5.3 and 4.42 mM, respectively, in Mfn1 or Mfn2 knockout MEF cells) or in MPP+-treated SH-SY5Y cells (5uM 24h), but not in MEF lacking both Mfn1/2 or the inner mitochondrial membrane (IMM) fusion mediator Opa1 (optic atrophy1). M1 (5uM 24h) is reported to boost the downregulated ATP5A & ATP5B protein level in Mfn1 or Mfn2 knockout MEF to the wild-type MEF level and ATPase inhibitor oligomycin at 5uM is shown to completely offset the mitochondrial fusion effect by 5uM M1 in Mfn1 knockout MEF. Comparing to mdivi-1, M1 exerts its effect via promoting fusion rather than inhibiting fission or division. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 1,1,1-Trichloro-Trifluoroethane | 1,1,1-Trichlorotrifluoroethane is used in the synthesis of isosteres showing potential to be β-turn promoters. Also used in the synthesis of fluoro-containing alkenes. Synonyms: 1,1,1-Trifluoro-2,2,2-trichloroethane; 1,1,1-Trifluorotrichloroethane. Grades: > 95%. CAS No. 354-58-5. Molecular formula: C2Cl3F3. Mole weight: 187.38. |  |
| 1,2-Bis(Triethoxysilyl)Ethane | It is Colorless transparent liquid. Uses: It can be used as adhesion promoter.used as additive to silane coupling agent formulations and enhance hydrolytic stability. used in corrosion resistant coating/primers for steel & aluminum. Group: Saltself-assembly materials self assembly and lithographyposs nanohybrid materials self assembly and contact printing materials. Alternative Names: Ethylenebis(triethoxysilane); triethoxy(2-triethoxysilylethyl)silane; 4,4,7,7-Tetraethoxy-3,8-dioxa-4,7-disiladecane. CAS No. 16068-37-4. Pack Sizes: 10 g; 100 g. Product ID: triethoxy(2-triethoxysilylethyl)silane. Molecular formula: 354.59. Mole weight: C14H34O6Si2. CCO[Si](CC[Si](OCC)(OCC)OCC)(OCC)OCC. InChI=1S/C14H34O6Si2/c1-7-15-21 (16-8-2, 17-9-3)13-14-22 (18-10-4, 19-11-5)20-12-6/h7-14H2, 1-6H3. IZRJPHXTEXTLHY-UHFFFAOYSA-N. 95%. |  |
| 1- [4- (tert-Butyldi methyl silyloxy methyl ) cyclohexyl] methyl idene] -1-phenylethanamine | Intermediate in the production of Rho kinase inhibitors and neurite outgrowth promoters. Group: Biochemicals. Alternative Names: N- [ [4- [ [ [ (1, 1-Dimethylethyl) dimethylsilyl] oxy] methyl] cyclohexyl] methylene] -α -methyl-benzenemethanamine. Grades: Highly Purified. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| (17 β)?-Estr-?4-?en-?17-?ol | (17 β)?-Estr-?4-?en-?17-?ol is an intermediate in synthesizing Ethylestrenol-d5 (E917832), an isotope labelled Ethylestrenol (E917830) is an anabolic steroid. Ethylestrenol is an illegal growth promoter used in livestock and are often tested for as part of a routine screening program for forbidden growth promoters. Group: Biochemicals. Grades: Highly Purified. CAS No. 3646-30-8. Pack Sizes: 10mg, 25mg. Molecular Formula: C18H28O. US Biological Life Sciences. | Worldwide |
| (1R) -N- ( (1R) -1-Phenylethyl) -1- [4- (tert-butyldi methyl silyloxy methyl ) cyclohexyl] ethan-1-amine | Intermediate in the production of Rho kinase inhibitors and neurite outgrowth promoters. Group: Biochemicals. Alternative Names: (α R) -N- [ (1R) -1- [4- [ [ [ (1, 1-Dimethylethyl) dimethylsilyl] oxy] methyl] cyclohexyl] ethyl] -α -methyl-benzenemethanamine. Grades: Highly Purified. CAS No. 672314-45-3. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| (1R) -N-Boc-1-[4- (hydroxymethyl) cyclohexyl]ethan-1-amine | Intermediate in the production of Rho kinase inhibitors and neurite outgrowth promoters. Group: Biochemicals. Alternative Names: (1R) -N- (tert-Butyloxycarbonyl) -1-[4- (hydroxymethyl) cyclohexyl]ethan-1-amine; [ (1R) -1- [4- (Hydroxymethyl) cyclohexyl] ethyl] carbamic Acid 1,1-Dimethylethyl Ester. Grades: Highly Purified. CAS No. 627314-62-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| (1R) -trans-4- [N-Boc-1-aminoethyl] cyclohexanecarboxylic Acid | Intermediate in the production of Rho kinase inhibitors and neurite outgrowth promoters. Group: Biochemicals. Alternative Names: trans-4- [ (1R) -1- [ [ (1, 1-Dimethylethoxy) carbonyl] amino] ethyl] cyclohexanecarboxylic Acid; trans-4- [ (R) -1- [ (tert-Butyloxycarbonyl) amino] ethyl] cyclohexanecarboxylic Acid. Grades: Highly Purified. CAS No. 671815-99-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexene-1-methanol | Intermediate in the production of cell death regulators and apoptosis promoters. Group: Biochemicals. Grades: Highly Purified. CAS No. 1027345-21-6. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| 2,4-Dinitrobenzenesulfenyl Chloride | 2,4-Dinitrobenzenesulfenyl Chloride is used in the modification of chlorea toxins and its promoters. Group: Biochemicals. Grades: Highly Purified. CAS No. 528-76-7. Pack Sizes: 100mg, 500mg. Molecular Formula: C6H3ClN2O4S, Molecular Weight: 234.62. US Biological Life Sciences. | Worldwide |
| 2-Benzothiazolethiol-d4 | 2-Benzothiazolethiol-d4. Group: Biochemicals. Alternative Names: 2-Benzothiazolethiol-d4; 2-Benzothiazolinethione-d4; 1,3-Benzothiazole-2-thiol-d4; 1,3-Benzothiazole-2-thione-d4; 2,3-Dihydrobenzothiazole-2-thione-d4; 2-Benzothiazolyl Mercaptan-d4; 2-MBT-d4; 2-Mercapto-1H-benzothiazole-d4; 2-Mercaptobenzothiazole-d4; 2-Mercaptobenzthiazole-d4; 2-Sulfanylbenzothiazole-d4; Accel M-d4; Accelerator M-d4; Aero 407-d4; Aero Promoter 412-d4; Benz-1,3-thiazolidine-2-thione-d4; Benzo[d]thiazole-2-thiol-d4; Benzothiazolethiol-d4; Captax-d4; Captax MBT-d4; DT 402-d4; Dermacid-d4; Ekagom G-d4; Kaptaks-d4; Kaptax-d4; Mebetizol-d4; Mebetizole-d4; Mebithizol-d4; Mercaptobenzothiazole-d4; Mercaptobenzthiazole-d4; Mertax-d4; NSC 2041-d4; Nocceler M-d4; Oricel M-d4. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 2-O-α-D-Glucosylglycerol | 2-O-α-D-Glucosylglycerol is used to prepare glycoglycerolipid analogs active as antitumor-promoters the influence of the anomeric configuration. Group: Biochemicals. Grades: Highly Purified. CAS No. 22160-26-5. Pack Sizes: 10mg, 100mg. Molecular Formula: C9H18O8. US Biological Life Sciences. | Worldwide |
| (3,3,3-Trifluoropropyl)Trimethoxysilane | It is an important monomeric silane which combines the excellent properties of both organosilicon and organic fluorine. In its molecule, there are reaction groups which can bond with inorganic materials and groups which can bond with organic polymers. It is normally used as a silane coupling agent or an fluoro intermediate. Uses: It is mainly used as a fluoro silane coupling agent and an adhesion promoter. it can be introduced to improve adhesion, mechanical properties and chemical properties of various composites. Additional or Alternative Names: 3-(Trimethoxysilyl)-1,1,1-trifluoropropane. Product Category: Biomaterials. Appearance: Clear liquid. CAS No. 429-60-7. Molecular formula: C6H13F3O3Si. Mole weight: 218.25. Purity: >96%. IUPACName: trimethoxy(3,3,3-trifluoropropyl)silane. Canonical SMILES: CO[Si](CCC(F)(F)F)(OC)OC. Density: 1.098 g/mL. ECNumber: 207-059-3. Product ID: ACM429607. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 3-[3-[4-(1,1-Dimethylethyl)phenoxy]-2-oxo-1-pyrrolidinyl]-benzoic Acid | 3-[3-[4-(1,1-Dimethylethyl)phenoxy]-2-oxo-1-pyrrolidinyl]-benzoic Acid is used in the preparation of acetylaminobenzoic acids as promoters of nonsense mutation suppression in messenger RNA (mRNA). Group: Biochemicals. Grades: Highly Purified. CAS No. 649774-32-3. Pack Sizes: 50mg, 250mg. Molecular Formula: C21H23NO4, Molecular Weight: 353.41. US Biological Life Sciences. | Worldwide |
| 3-Glycidoxypropyldimethoxymethylsilane | 3-Glycidoxypropyldimethoxymethylsilane. Uses: It is an excellent candidate for formulations employing carboxylated latexes (acrylic, sbr polyurethane, etc. ) exhibiting a ph between 6 and 8.5. it can be employed as an adhesion promoter or crosslinker. it may be suitable for use as a water stable single component crosslinker in applications such as: automotive laminate adhesives, furniture laminate adhesives, flcking adhesives. Group: Self-assembly materials. Alternative Names: 3- (2, 3-Epoxypropoxypropyl) methyldimethoxysilane. CAS No. 65799-47-5. Pack Sizes: Packed with 5 L, 20 L or 210 L plastic/steel drum, 1000 L IBC container, or according to customer's requirement. Product ID: Dimethoxy-methyl-[3-(oxiran-2-ylmethoxy)propyl]silane. Molecular formula: 220.34. Mole weight: C9H20O4Si. CO[Si](C)(CCCOCC1CO1)OC. InChI=1S/C9H20O4Si/c1-10-14(3, 11-2)6-4-5-12-7-9-8-13-9/h9H, 4-8H2, 1-3H3. WHGNXNCOTZPEEK-UHFFFAOYSA-N. 95%+. | |
| 3- (Glycidoxypropyl) methyldiethoxysilane | 3- (Glycidoxypropyl) methyldiethoxysilane, silane coupling agent KH-7180, is a versatile epoxy organo-reactive silane with two hydrolyzable ethoxy groups. It provides shelf stable non-yellowing adhesion promoter performance while enhancing physical properties in latexes and waterborne adhesive and sealant systems. Group: Biochemicals. Grades: Highly Purified. CAS No. 2897-60-1. Pack Sizes: 10g, 50g. Molecular Formula: C11H24O3Si, Molecular Weight: 232.39. US Biological Life Sciences. | Worldwide |
| 3-Glycidoxypropyltrimethoxysilane | It is epoxy functional silane used as adhesion promoters in SPUR, urethane, epoxy, polysulfide, silicone, and acrylic caulks, coatings, sealants and adhesives. Uses: It can improve the dry and wet strength of cured composites reinforced by glass fiber rovings, enhance the wet electrical properties of epoxy resin-based encapsulation and packaging materials, without the need to use separate primers in polysulfide and polyurethane sealants, and improve water-based acrylic adhesion of sealant, polyurethane and epoxy coatings. Group: Polymers. Alternative Names: Tetraethyl Orthosilicate ?Ethyl Silicate); Etylukrzemian(Polish); Silane, Tetraethoxy-; Silane,Tetraethoxy-; Silbond Condensed; Silester; Silicate D'Ethyle; Silicate Tetraethylique. CAS No. 2530-83-8. Pack Sizes: Packed with 5 L, 20 L or 210 L plastic/steel drum, 1000 L IBC container, or according to customer's requirement. Product ID: 3-Glycidoxypropyltrimethoxysilane. Molecular formula: 236.34. Mole weight: C9H20O5Si. 98%. | |
| 4-[ (3R) -3-Amino-1-oxo-4- (phenylthio) butyl]morpholine | Intermediate in the production of cell death regulators and apoptosis promoters. Group: Biochemicals. Alternative Names: (3R)-3-Amino-1-(4-morpholinyl)-4-(phenylthio)-1-butanone. Grades: Highly Purified. CAS No. 870812-94-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]benzoic Acid | Intermediate in the production of cell death regulators and apoptosis promoters. Group: Biochemicals. Grades: Highly Purified. CAS No. 1044598-91-5. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]benzoic Acid Ethyl Ester | Intermediate in the production of cell death regulators and apoptosis promoters. Group: Biochemicals. Grades: Highly Purified. CAS No. 1065604-70-7. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 4-Chloroindole-3-acetic Acid | 5,6-Dichloroindole-3-acetic acid and 4-Chloroindole-3-acetic acid are potent candidates for new rooting promoters without estrogenic activity. Plant growth stimulators. Group: Biochemicals. Alternative Names: 4-Chloro-1H-indole-3-acetic Acid; 4-Chloro-IAA; 4-Chloroindoleacetic Acid; 4-Chloroindolyl-3-acetic Acid; NSC 295294. Grades: Highly Purified. CAS No. 2519-61-1. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| [4- (tert-Butyldi methyl silyloxy methyl ) cyclohexyl] methanol. | Intermediate in the production of Rho kinase inhibitors and neurite outgrowth promoters. Group: Biochemicals. Alternative Names: 4- [ [ [ (1, 1-Dimethylethyl) dimethylsilyl] oxy] methyl] cyclohexanemethanol. Grades: Highly Purified. CAS No. 141836-50-2. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| 5-[[3-Bromo-4- (2-cyclohexylethoxy) phenyl]methylene]-2, 4-thiazolidinedione | A thiazolidinedione analogue prepared for use as a 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor and wound healing promoter. Group: Biochemicals. Grades: Highly Purified. CAS No. 1239610-74-2. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| 5-[[3-Chloro-4- (2-cyclohexylethoxy) phenyl]methylene]-2, 4-thiazolidinedione | A thiazolidinedione analogue prepared for use as a 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor and wound healing promoter. Group: Biochemicals. Grades: Highly Purified. CAS No. 1239610-72-0. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| 5- [ [4- (2-Cyclohexylethoxy) -3-methoxyphenyl] methylene] -2, 4-thiazolidinedione | A thiazolidinedione analogue prepared for use as a 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor and wound healing promoter. Group: Biochemicals. Grades: Highly Purified. CAS No. 1239610-60-6. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| 6,2',4'-Trimethoxyflavone | 6,2',4'-Trimethoxyflavone is an aryl hydrocarbon receptor antagonist (EC50 = 0.9 μM), displaying no short term agonist activity and no species or promoter dependence. Synonyms: 2-(2,4-Dimethoxyphenyl)-6-methoxy-4H-chromen-4-one; 2',4',6-Trimethoxyflavone; 4H-1-Benzopyran-4-one, 2-(2,4-dimethoxyphenyl)-6-methoxy-; 2-(2,4-Dimethoxyphenyl)-6-methoxy-4H-1-benzopyran-4-one. Grades: ≥97% by HPLC. CAS No. 720675-74-1. Molecular formula: C18H16O5. Mole weight: 312.32. | |
| 6-Ketocholestanol (5a-Cholestan-6-one) | An oxygenated cholesterol which can be used as a ligand for cytosolic-nuclear tumor promoter binding protein. Group: Biochemicals. Alternative Names: 5a-Cholestan-6-one. Grades: Highly Purified. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| Aaptamine | Aaptamine, a spongean alkaloid isolated from a sea sponge Aaptos aaptos, is a competitive antagonist of α-adrenoceptor and activates the p21 promoter in a p53-independent manner. Synonyms: 8,9-dimethoxy-1H-benzo[de][1,6]naphthyridine. Grades: ≥95%. CAS No. 85547-22-4. Molecular formula: C13H12N2O2. Mole weight: 228.3. | |
| Actaplanin A | Actaplanin, a new complex of broad spectrum Gram-positive antibiotics, is produced by Actinoplanes missouriensis. It is used as a growth promoter to increase milk production. Molecular formula: C90H101O40N8Cl. Mole weight: 1970.24. | |
| Actaplanin B1 | Actaplanin B1, a broad spectrum Gram-positive antibiotics, is produced by Actinoplanes missouriensis. It is used as a growth promoter to increase milk production. Synonyms: 1H, 15H, 34H-20, 23:30, 33-Dietheno-3, 18:35, 48-bis(iminomethano)-4, 8:10, 14:25, 28:43, 47-tetrametheno-28H-(1, 14, 6, 22)dioxadiazacyclooctacosino(4, 5-m)(10, 2, 16)benzoxadiazacyclotetracosine, actaplanin B1 deriv. CAS No. 88357-82-8. Molecular formula: C90H101O39N8Cl. Mole weight: 1954.24. | |
| AIM-100 | AIM-100 is a potent and selective Ack1 tyrosine kinase with IC50 value of 24 nM. AIM-100, not only inhibited Ack1 activation but also able to suppress pTyr267-AR phosphorylation, binding of AR to PSA, NKX3.1, and TMPRSS2 promoters, and inhibit AR transcription activity. Ack1 tyrosine kinase activation correlates with pancreatic cancer progression. Ack1 inhibitors hold promise for therapeutic intervention to inhibit pancreatic tumor growth. Uses: Designed for use in research and industrial production. Additional or Alternative Names: AIM-100; AIM 100; AIM100. Product Category: Others. Appearance: Solid powder. CAS No. 873305-35-2. Molecular formula: C23H21N3O2. Mole weight: 371.44. Purity: >98%. IUPACName: N-[[(2S)-oxolan-2-yl]methyl]-5,6-diphenylfuro[2,3-d]pyrimidin-4-amine. Canonical SMILES: C12=NC=NC(NC[C@H]3OCCC3)=C1C(C4=CC=CC=C4)=C(C5=CC=CC=C5)O2. Product ID: ACM873305352. Alfa Chemistry ISO 9001:2015 Certified. | |
| AIM-100 | AIM-100 is a small molecule inhibitor of Ack1. It not only inhibited Ack1 activation but also suppressed AKT tyrosine phosphorylation, leading to cell cycle arrest in the G1 phase. It could suppress AR Tyr(267) phosphorylation and its recruitment to the ATM enhancer and suppress pTyr267-AR phosphorylation, binding of AR to PSA, NKX3.1, and TMPRSS2 promoters, and inhibit AR transcription activity. Synonyms: AIM-100; AIM 100; AIM100. Grades: >98%. CAS No. 873305-35-2. Molecular formula: C23H21N3O2. Mole weight: 371.43. | |
| α-?Chaconine | α-Chaconine inhibits the expressions of COX-2 , IL-1β , IL-6 , and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects [1]. Uses: Scientific research. Group: Natural products. CAS No. 20562-03-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-129113. |  |
| α-Copaene | α-Copaene, a sesquiterpene hydrocarbon, is a fruit volatile. α-Copaene can be used as an oviposition promoter of Bactrocera oleae [1]. Uses: Scientific research. Group: Natural products. CAS No. 3856-25-5. Pack Sizes: 5 mg; 1 mg. Product ID: HY-122485. | |
| Anhydrotetracycline hydrochloride | Anhydrotetracycline acts as an inducer of tetracycline resistance genes by binding to and inactivating the tetracycline repressor TetR to allow expression of downstream genes of the tetr promoter. However, anhydrotetracycline binds to the TetR repressor with higher affinity without toxic effects. Anhydrotetracycline poorly binds the 30S ribosomal subunit, the concentration of anhydrotetracycline that inhibits eukaryotic cell growth is more than 1,000-fold above the dose that alters transcription through TetR. Synonyms: (4S,4aS,12aS)-4-(Dimethylamino)-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-1,4,4a,5,12,12a-hexahydro-2-tetracenecarboxamide hydrochloride (1:1). Grades: ≥98%. CAS No. 13803-65-1. Molecular formula: C22H22N2O7.HCl. Mole weight: 462.88. | |
| AP1867-2-(carboxymethoxy) | AP1867-2-(carboxymethoxy), the AP1867 (a synthetic FKBP12F36V-directed ligand) based moiety, binds to CRBN ligand via a linker to form dTAG molecules. It is a ligand and a binder that contributes to the enhancer-promoter structural interactions of DNA elements. Synonyms: PROTAC FKBP12-binding moiety 2; 2-(2-((R)-3-(3,4-Dimethoxyphenyl)-1-(((S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carbonyl)oxy)propyl)phenoxy)acetic acid; 2-Piperidinecarboxylic acid, 1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-, (1R)-1-[2-(carboxymethoxy)phenyl]-3-(3,4-dimethoxyphenyl)propyl ester, (2S)-; Ortho-AP1867. Grades: ≥96%. CAS No. 2230613-03-1. Molecular formula: C38H47NO11. Mole weight: 693.78. | |
| AS 1269574 | GPR119 has been found to be a GPR119 agonist and could stimulate the activity of proglucagon gene promoter. Synonyms: AS1269574; AS-1269574; AS 1269574; 2-[[2-(4-Bromophenyl)-6-methyl-4-pyrimidinyl]amino]ethanol. Grades: ≥98% by HPLC. CAS No. 330981-72-1. Molecular formula: C13H14BrN3O. Mole weight: 308.17. | |
| Azone | Azone. CAS No. 59227-89-3. Product ID: PE-0623. Molecular formula: C18H35NO. Mole weight: 281.48. Category: Surfactant. Product Keywords: Excipients for Liquid Dosage Form; Surfactant Excipients; PE-0623; Azone; Surfactant; C18H35NO; 59227-89-3. UNII: NA. Chemical Name: 1-dodecyl azocyclic heptanone 2-ketone. Grade: Pharmceutical Excipients. Administration route: Administration by injection, oral administration, percutaneous administration, vaginal administration. Dosage Form: injection, oral, percutaneous , vaginal preparations. Stability and Storage Conditions: It is stable to heat, but not to acid and base. Other functional components in the formula may separate oil from water. Source and Preparation: It is prepared by the reaction of bromododecane with caprolactam in the presence of strong bases such as metallic sodium and sodium hydroxide, or in the condition of phase transfer catalysis of quaternary ammonium salts. Applications: Azone, as an efficient skin penetration enhancer and a new type of non-ionic surfactant, has been widely applied in the fields of medicine, daily chemical, pesticide, printing and dyeing, chemical fiber, leather and so on. Safety: When the concentration is less than 50%, it has no irritation to the skin. It is a non-toxic, safe and efficient transdermal absorption promoter. |  |
| BRD 7552 | PDX1 transcription factor inducer; up regulates PDX1 expression in both primary human islets and ductal cells. Induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. Increases insulin expression in PANC-1 cells, primary human islets and human duct-derived cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 1137359-47-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| CARM1 Inhibitor (1-Benzyl-3, 5-bis- (3-bromo-4-hydroxybenzylidene) piperidin-4-one, 3,5-bis(3-Bromo-4-hydroxybenzylidene)-1-benzylpiperidin-4-one, Coactivator-Associated Arginine Methyltransferase 1 Inhibitor, PRMT Inhibitor V) | A cell-permeable (bis-benzylidene) piperidinone compound that acts as a selective inhibitor against CARM1/PRMT4 arginine methyltransferase activity (IC50=7.1uM with PABP1 as substrate). It inhibits PRMT3 only at much higher concentrations (by 70% and 62% with 100uM inhibitor using NPL3 or rpS2 as substrate, respectively), exhibiting little activity against PRMT1, PRMT5, PRMT6 (IC50>100uM), or four HKMTs (<20% inhibition against DOTL1, G9a, SET7, or Suv39H1 with 100uM inhibitor). Shown to inhibit PSA promoter-mediated reporter transcription in LNCaP cells in a dose-dependent manner (by 74% and 97%, respectively, with 4 and 6uM inhibitor). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Casein Kinase II Inhibitor XII, TBBz (4, 5, 6, 7-Tetra bromobenzimidazole, CYP24A1 inhibitor, TBBz, CK2 Inhibitor, TBBz) | A cell-permeable halogenated benzimidazole compound that acts as a selective and ATP competitive inhibitor of casein kinase II (CK2, Ki = 70nM for the active hetero-tetrameric form). However, its effect on free CK2a and CK2a' subunits is significantly reduced (Ki = 510 and 400nM, respectively). Reported to reduce viability and proliferation in HeLa, Jurkat, and HL-60 cells (at 25uM). Also shown to disrupt the promoter activity of CYP24A1 and down-regulates its endogenous and 1, 25-Vitamin D3 (1,25-D3)-induced expression in PC3 cells. Synergistically enhances the anti-tumor effect of 1, 25-D3 in a PC3 xenograft murine model. CAS No:577779-57-8. Group: Biochemicals. Grades: Highly Purified. CAS No. 577779-57-8. Pack Sizes: 20mg. Molecular Formula: C?H?Br?N?, Primary Target: CK2. US Biological Life Sciences. | Worldwide |
| CEF27, Epstein-Barr Virus BRLF-1 lytic 148-156 acetate | CEF27, Epstein-Barr Virus BRLF-1 lytic 148-156 acetate is the 148-156 amino acid fragment of the BRLF1 protein. BRLF1 is a transcriptional activator that directly binds to the GC-rich motif in the promoter of EBV lytic gene. Synonyms: L-Arginyl-L-valyl-L-arginyl-L-alanyl-L-tyrosyl-L-threonyl-L-tyrosyl-L-seryl-L-lysine acetate salt; H-Arg-Val-Arg-Ala-Tyr-Thr-Tyr-Ser-Lys-OH.CH3CO2H; L-arginyl-L-valyl-L-arginyl-L-alanyl-L-tyrosyl-L-threonyl-L-tyrosyl-L-seryl-L-lysine acetic acid. Grades: ≥95%. Molecular formula: C53H86N16O16. Mole weight: 1203.35. | |
| Chitosan | Active ingredient chitosan is de-acylated chitin. Derived from crustacean shells. Used as film-former and hair-fixative. Also used as deodorising agent. It possesses antimicrobial and excellent skin care properties. It prevents the excessive generation of odor-forming substances. Uses: In the agricultural sector: as growth promoters, bio-pesticides, feed additives, seed treatment. Group: 3d printing materials biodegradable polymerspolysaccharide. Alternative Names: Chitin, deacylated. CAS No. 9012-76-4. Product ID: Methyl N-[(2S,3R,4R,5S,6R)-5-[(2S,3R,4R,5S,6R)-3-amino-5-[(2S,3R,4R,5S,6R)-3-amino-5-[(2S,3R,4R,5S,6R)-3-amino-5-[(2S,3R,4R,5S,6R)-3-amino-5-[(2S,3R,4R,5S,6R)-3-amino-5-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-[(2R,3S,4R,5R,6S)-5-amino-6-[(2R,3S,4R,5R,6R)-5-amino-4,6-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-3-yl]carbamate. Molecular formula: 1526.5g/mol. Mole weight: C6H13NO4. COC (=O)N[C@@H]1[C@H] ([C@@H] ([C@H] (O[C@H]1O[C@@H]2[C@H] (O[C@H] ([C@@H] ([C@H]2O)N)O[C@@H]3[C@H] (O[C@H] ([C@@H] ([C@H]3O)N)O)CO)CO)CO)O[C@H]4[C@@H] ([C@H] ([C@@H] ([C@H] (O4)CO)O[C@H]5[C@@H] ([C@H] ([C@@H] ([C@H] (O5)CO)O[C@H]6[C@@H] ([C | |
| Chitosan | Active ingredient chitosan is de-acylated chitin. Derived from crustacean shells. Used as film-former and hair-fixative. Also used as deodorising agent. It possesses antimicrobial and excellent skin care properties. It prevents the excessive generation of odor-forming substances. Uses: In the agricultural sector: as growth promoters, bio-pesticides, feed additives, seed treatment. Group: other nano materials. Alternative Names: Chitin, deacylated. CAS No. 9012-76-4. Product ID: Methyl N-[(2S,3R,4R,5S,6R)-5-[(2S,3R,4R,5S,6R)-3-amino-5-[(2S,3R,4R,5S,6R)-3-amino-5-[(2S,3R,4R,5S,6R)-3-amino-5-[(2S,3R,4R,5S,6R)-3-amino-5-[(2S,3R,4R,5S,6R)-3-amino-5-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-[(2R,3S,4R,5R,6S)-5-amino-6-[(2R,3S,4R,5R,6R)-5-amino-4,6-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-3-yl]carbamate. Molecular formula: 1526.5g/mol. Mole weight: C6H13NO4. COC (=O)N[C@@H]1[C@H] ([C@@H] ([C@H] (O[C@H]1O[C@@H]2[C@H] (O[C@H] ([C@@H] ([C@H]2O)N)O[C@@H]3[C@H] (O[C@H] ([C@@H] ([C@H]3O)N)O)CO)CO)CO)O[C@H]4[C@@H] ([C@H] ([C@@H] ([C@H] (O4)CO)O[C@H]5[C@@H] ([C@H] ([C@@H] ([C@H] (O5)CO)O[C@H]6[C@@H] ([C@H] ([C@@H] ([C@H] (O6)CO)O[C@H]7[C@@H | |
| Cl-4AS-1 | Cl-4AS-1 is a mouse mammary tumor virus (MMTV) promoter and represses MMP1 promoter activity. It also inhibits 5α-Reductase type I and II with IC50 values of 6 and 10 nM respectively, as well as is a potent steroidal androgen receptor agonist with IC50 value of 12 nM. It mimics the action of 5α-dihydrotestosterone (DHT). Synonyms: (4aα, 4bβ, 6aα, 7α, 9aβ, 9bα, 11aβ)-N-(2-Chlorophenyl)-2, 4a, 4b, 5, 6, 6a, 7, 8, 9, 9a, 9b, 10, 11, 11a-tetradecahydro-1, 4, 6a-trimethyl-2-oxo-1H-indeno[5, 4-f]quinoline-7-carboxamide. Grades: ≥99% by HPLC. CAS No. 188589-66-4. Molecular formula: C26H33ClN2O2. Mole weight: 441.01. | |
| Clenbuterol-d9 (1-4-Amino-3,5-dichlorophenyl)-2-tert-butylamino-d9-ethanol) | A ß-Agonist which can be used as a growth promoter in farm animals. Group: Biochemicals. Alternative Names: 1-4-Amino-3,5-dichlorophenyl)-2-tert-butylamino-d9-ethanol. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Clenbuterol, Hydrochloride | Substituted phenylethanolamine with β2 sympathomimetic activity. Bronchodilator. A β-Agonist which can be used as a growth promoter in farm animals. Neuroresearch product. Group: Biochemicals. Alternative Names: 4-Amino-3, 5-dichloro-a- [ [ (1, 1-dimethylethyl) amino] methyl] benzenemethanol, NAB-365Cl, Spiropent, Ventipulmin. Grades: Highly Purified. CAS No. 21898-19-1. Pack Sizes: 50mg, 100mg, 250mg. Molecular Formula: C12H19Cl3N2O, Molecular Weight: 313.65. US Biological Life Sciences. | Worldwide |
| Clencyclohexerol | An analog of Clenbuterol, a β-agonist which can be used as a growth promoter in farm animals. Group: Biochemicals. Alternative Names: 4-Amino-3, 5-dichloro-α - [ [ (4-hydroxycyclohexyl) amino] methyl] benzenemethanol. Grades: Highly Purified. CAS No. 157877-79-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Clencyclohexerol | Clencyclohexerol is an analog of Clenbuterol and is used as a reagent in the synthesis of pyrazolopyridine derivatives as inhibitors of phosphodiesterase-4 (PDE-IV) and production of tumor necrosis factor-α (TNF-α). Uses: An analog of clenbuterol, a β-agonist which can be used as a growth promoter in farm animals. Synonyms: 4-Amino-3, 5-dichloro-α -[[ (4-hydroxycyclohexyl) amino]methyl]benzenemethanol; Benzenemethanol, 4-amino-3,5-dichloro-α-[[(4-hydroxycyclohexyl)amino]methyl]-; 4-{[2-(4-Amino-3,5-dichlorophenyl)-2-hydroxyethyl]amino}cyclohexanol. Grades: 98%. CAS No. 157877-79-7. Molecular formula: C14H20Cl2N2O2. Mole weight: 319.23. | |
| Clenproperol | A related drug of Clenbuterol, a β-agonist which can be used as a growth promoter in farm animals. Group: Biochemicals. Alternative Names: 4-Amino-3, 5-dichloro-α - [ [ (1-methylethyl) amino] methyl] benzenemethanol. Grades: Highly Purified. CAS No. 38339-11-6. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| c-Myc Inhibitor III, Mycro2 (5- (Thiophen-2-yl) -N- (thiophen-2-ylmethyl) -7- (trifluoromethyl) pyrazolo[1, 5-a]pyrimidine-2-carboxamide) | A cell-permeable pyrazolopyrimidine-carboxamide that selectively inhibits c-Myc-Max dimer DNA binding activity (IC50=23uM) by preventing c-Myc-Max heterodimer formation, while affecting Max, Jun, C/EBPa homodimers, or Jun-Fos heterodimer DNA binding only at much higher concentrations (IC50=>54uM). Shown to selectively inhibit c-Myc-Max-dependent transcription (by 77% against E-Box promoter-driven reporter transcription at 10uM), cancer proliferation, and anchorage-independent colony formation (Effective conc. 10-20uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Corylin | Corylin is a major bioactive compound isolated from Psoralea corylifolia L; antibiotic or anticancer compound.IC50 value:Target:in vitro: Corylin showed an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC50 value of 1.37 uM. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 7-Hydroxy-2',2'-dimethyl-2'H,4H-3,6'-bichromen-4-one. Product Category: Inhibitors. Appearance: Light-yellow powder. CAS No. 53947-92-5. Molecular formula: C20H16O4. Mole weight: 320.34. Purity: 0.98. IUPACName: 3-(2,2-Dimethylchromen-6-yl)-7-hydroxychromen-4-one. Canonical SMILES: CC1(C=CC2=C(O1)C=CC(=C2)C3=COC4=C(C3=O)C=CC(=C4)O)C. Density: 1.295±0.06 g/ml. Product ID: ACM53947925. Alfa Chemistry ISO 9001:2015 Certified. Categories: Cory in the House. | |
| Corylin | Corylin is an orally active flavonoid anti-inflammatory and osteogenic agent that inhibits IL-6-induced STAT3 promoter activity and STAT3 phosphorylation. Corylin also has anticancer, antiatherosclerotic, and ameliorating activity in hyperlipidemia and insulin resistance, inducing adipocyte browning and lipolysis through SIRT1 or β3-AR-dependent pathways [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 53947-92-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0236. | |
| Elaiophylin | It is produced by the strain of Streptomyces melanosporofacien. It has the activity of anti-gram-positive bacteria, mycobacterium and protozoa, and can be used as insect repellent and growth promoter for ruminants. Elaiophylin is an autophagy inhibitor, which exerts antitumor activity as a single agent in ovarian cancer cells. Synonyms: Azalomycin B; Salbomycin; Azalomycin B; Antibiotic 5001B; Antibiotic 56-62; Elaiofilin. Grades: ≥95%. CAS No. 37318-06-2. Molecular formula: C54H88O18. Mole weight: 1025.26. | |
| Ethyltriacetoxysilane | Triacetoxysilyl ethyl does not contain any additives such as catalysts, stabilizers or adhesion promoters. Usually used as a curing agent. Group: Silicone. Alternative Names: Ethyltriacetoxysilane; [diacetyloxy(ethyl)silyl] acetate; Triacetoxy(Ethyl)Silane; (Triacetoxy)ethylsilane. CAS No. 17689-77-9. Pack Sizes: 10 g; 100 g. Product ID: [diacetyloxy(ethyl)silyl]acetate. Molecular formula: 243.28 g/mol. Mole weight: C8H14O6Si. CC[Si](OC(=O)C)(OC(=O)C)OC(=O)C. KXJLGCBCRCSXQF-UHFFFAOYSA-N. 0.95. | |
| Factumycin | It is a polyene antibiotic produced by the strain of Streptomyces lavendulae MA-4758. It has the activity of anti-gram-positive bacteria and gram-negative bacteria, and is an animal growth promoter. Synonyms: Antibiotic A 40A; Mocimycin, 14,17-deepoxy-14,15-didehydro-15,30-dideoxy-17-hydroxy-1-methyl-, (14Z)-; 2H-Pyran-2-acetamide, N-[(2E,4E,6S,7S,9S,10E,12E,14E,16E)-18-(1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-pyridinyl)-8,9-dihydroxy-6-methoxy-5,7,17-trimethyl-18-oxo-2,4,10,12,14,16-octadecahexaen-1-yl]-a-ethyltetrahydro-2,4-dihydroxy-5,5-dimethyl-6-(1E,3Z)-1,3-pentadien-1-yl-, (aS,2S,4S,6S)-. CAS No. 84600-89-5. Molecular formula: C44H62N2O10. Mole weight: 778.97. | |
| Fmoc-L-isoleucine | N-Fmoc-L-isoleucine is an N-Fmoc-protected form of L-Isoleucine. L-Isoleucine is classified as an essential amino acid, and is also a tumour promoter of bladder cancer in rats. Synonyms: Fmoc-L-Ile-OH; Fmoc-(2S,3S)-2-amino-3-methylpentanoic acid. Grades: ≥ 99% (HPLC). CAS No. 71989-23-6. Molecular formula: C21H23NO4. Mole weight: 353.40. | |
| Fumonisin B1 | Fumonisin B1 is produced by the strain of Gibberella fujikuroi and Fumarium moniliforme. It is a liver toxin, which can activate the cancer promoter and cause liver cancer. It has been reported that it is related to the occurrence of human esophageal cancer in South Africa and other places. It can also cause pig pulmonary edema, and is also the pathogenic substance of equine leukoencephalitis. Fumonisin B1 inhibits sphingosine acyltransferase. Synonyms: Macrofusine; Macrofusine; NSC 629151; (R)-3-Carboxy-pentanedioic acid mono-{(1S,3S,5R,10R,12S,13S)-13-amino-1-[(1R,2R)-1-((R)-3,4-dicarboxy-butyryloxy)-2-methyl-hexyl]-5,10,12-trihydroxy-3-methyl-tetradecyl} ester. Grades: ≥98%. CAS No. 116355-83-0. Molecular formula: C34H59NO15. Mole weight: 721.83. | |
| G3130 | G3130 is a reversible Hsp90 inhibitor with potential anticancer activity. G3130 demonstrated cellular activities (in Her-2 degradation and activation of Hsp70 promoter) consistent with the inhibition of cellular Hsp90 functions. Synonyms: G-3130; G 3130; 4-(4-(1H-imidazol-4-yl)-1H-pyrazol-3-yl)-6-ethylbenzene-1,3-diol. Grades: 98%. CAS No. 848952-37-4. Molecular formula: C14H14N4O2. Mole weight: 270.29. | |
| Galactose, Low Endotoxin, Low Glucose (D-Galactose) | D-Galactose is a C-4 epimer of Glucose found in milk and sugar beets as well as being synthesized by the body. Galactose is made from lactose through hydrolysis reaction under acidic conditions. Galactose is a simple monosaccharide that serves as an energy source and as an essential component of glycolipids and glycoproteins. Galactose contributes to energy metabolism via its conversion to glucose by the enzymes that constitute the Leloir pathway. Defects in the genes encoding these proteins lead to the metabolic disorder galactosemia. Applications:Used as an alternate carbon source for wild-type yeastInduces transcription of sequences fused to the GAL10 promoterSuitable for use in two-hybrid protocols. Component of galactosyltransferase labeling bufferSupplement in MRS broth for the growth of thermophilic lactobacilliInduces the expression of uncoupling protein (UCP) in yeast transformantsOral therapy for nephrotic syndrome in focal and segmental glomerulosclerosis. Group: Biochemicals. Alternative Names: D-(+)-Galactose; Dextrogalactose; Lactoglucose; alpha-Galactose(D). Grades: Molecular Biology Grade. CAS No. 59-23-4. Pack Sizes: 100g, 500g, 1Kg, 5Kg, 10Kg. Molecular Formula: C6H12O6, Molecular Weight: 180.16. US Biological Life Sciences. | Worldwide |
| Glycitein | Glycitein is a soybean (yellow cultivar) isoflavonoid. It may be used to study anti-oxidation processes at the level of gene transcription where it increases the binding of transcription factors [nuclear factor-E2-related factor 2 (Nrf2) and c-Jun] to the antioxidant response element (ARE) on HO-1 and NQO1 promoters. Uses: The compund shows an anti-cancer activity. Synonyms: 7-Hydroxy-3-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-hydroxyphenyl)-6-methoxy-; 7-Hydroxy-3-(4-hydroxyphenyl)-6-methoxy-4-chromenone; 4',7-Dihydroxy-6-methoxyisoflavone. Grades: >98%. CAS No. 40957-83-3. Molecular formula: C16H12O5. Mole weight: 284.26. | |
| GNF2133 HCl | GNF2133 is a potent and selective DYRK1A inhibitor (IC50 = 6 nM). In vitro, GNF2133 is able to proliferate both rodent and human β-cells. In vivo, GNF2133 demonstrated significant dose-dependent glucose disposal capacity and insulin secretion in response to glucose-potentiated arginine-induced insulin secretion (GPAIS) challenge in rat insulin promoter and diphtheria toxin A (RIP-DTA) mice. Uses: Designed for use in research and industrial production. Additional or Alternative Names: GNF2133 HCl; GNF2133 hydrochloride; GNF2133; GNF-2133; GNF 2133. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2561414-57-9. Molecular formula: C24H31ClN6O2. Mole weight: 471. Purity: >98%. IUPACName: 4-Ethyl-N-(4-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)pyridin-2-yl)piperazine-1-carboxamide hydrochloride. Canonical SMILES: O=C(N1CCN(CC)CC1)NC2=NC=CC(C3=CN(C4CCOCC4)C5=C3C=CN=C5)=C2.[H]Cl. Product ID: ACM2561414579. Alfa Chemistry ISO 9001:2015 Certified. | |
| Gold Surface Cleaning solution | Gold Surface Cleaning solution. Uses: Recommended for cleaning metal films immediately prior to further processing. gold/silver cleaner is an effective surface activator and adhesion promoter for gold and silver substrates prior to bonding processes. Group: Self assembly and lithographysubstrates and electrode materials. Alternative Names: Gold surface prep solution,Silver Surface Cleaning Solution. Pack Sizes: 500 mL in poly bottle. | |
| Halofuginone | Halofuginone is a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases. Uses: Semisynthetic quinazolinone alkaloid anticoccidial. Synonyms: Halofuginone; Tempostatin; RU 19110; RU19110; RU-19110. Grades: > 95%. CAS No. 55837-20-2. Molecular formula: C16H17BrClN3O3. Mole weight: 414.684. | |
| Histidyl-tRNA Synthetase from Human, Recombinant | Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Histidyl-trna synthetase human recombinant produced in...thetase is purified by proprietary chromatographic techniques. Group: Enzymes. Synonyms: Histidyl-tRNA synthetase; EC 6.1.1.21; Histidine-tRNA ligase; HisRS; HRS; FLJ20491; JO-1. Enzyme Commission Number: EC 6.1.1.21. CAS No. 9068-78-4. Purity: Greater than 90.0% as determined by both (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. HRS. Stability: Histidyl-tRNA Synthetase although stable at 4°C for 3 weeks, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles. Appearance: Sterile Filtered clear solution. Source: E. coli. Species: Human. Histidyl-tRNA synthetase; EC 6.1.1.21; Histidine-tRNA ligase; HisRS; HRS; FLJ20491; JO-1. Cat No: NATE-0848. |  |
| HJC-0123 | HJC-0123 is a potent and selective STT 3 inhibitor. HJC0123 has demonstrated to inhibit STAT3 promoter activity, downregulate phosphorylation of STAT3, increase the expression of cleaved caspase-3, inhibit cell cycle progression and promote apoptosis in breast and pancreatic cancer cells with low micromolar to nanomolar IC50 values. Furthermore, HJC-0123 significantly suppressed estrogen receptor (ER)-negative breast cancer MDA-MB-231 xenograft tumor growth in vivo (p.o.), indicating its great potential as an efficacious and orally bioavailable drug candidate for human cancer therapy. Synonyms: HJC 0123; HJC0123; 2-Phenyl-quinoline-4-carboxylic acid (1,1-dioxo-1H-1lambda6-benzo[b]thiophen-6-yl)-amide. Grades: 98%. CAS No. 1430420-02-2. Molecular formula: C24H16N2O3S. Mole weight: 412.46. | |
| HNF4 Antagonist, BI6015 (2-Methyl-1-(2-methyl-5-nitrophenylsulfonyl)-1H-benzo[d]imidazole, Hepatocyte Nuclear Factor4 Antagonist) | A cell-permeable phenyl sulfonyl benzimidazole that is shown to dock in the ligand-binding pocket of both HNF4a and HNF4g and antagonize HNF4a DNA binding activity in HepG2 cells (by 93%; 10uM overnight), effectively inhibiting HNF4a-dependent cellular activities (Effective conc. 1 to 5uM). HNF4g inhibition by BI6015 can also lead to decreased insulin promoter binding by transactivators E47 & PDX-1 in T6PNE cells (5uM 48h). Although BI6015 is found to exhibit cancer-selective cytotoxicity toward a panel of 58 human cancer cells and Hep3B-Luc (Effective conc. 1 to 10uM), but not primary murine hepatocytes, it does cause hepatic steatosis both in vitro and in mice in vivo, limiting its use in animal studies. BI6015 also inhibits Human CYP450 2C19 and rat L-type calcium channel (by 94% and 83%, respectively, at 10uM), but not PPARg or a panel of 41 receptors/enzymes of human, mouse, and rat origin. Group: Biochemicals. Grades: Highly Purified. CAS No. 93987-29-2. Pack Sizes: 25mg. Molecular Formula: C??H??N?O?S, Molecular Weight: 331.4. US Biological Life Sciences. | Worldwide |
| Hydroxymethyl Clenbuterol | Hydroxymethyl Clenbuterol is a β-agonist which can be used as a growth promoter in farm animals. Other β2-Agonists with effects on animal growth are: Mabuterol, Mapenterol, Clenproperol, Terbutaline, Clenbuterol, Salbutamol, Clenpenterol, Bromobuterol. Synonyms: 4-Amino-3, 5-dichloro-α -[[ (2-hydroxy-1, 1-dimethylethyl) amino]methyl]benzenemethanol; NA 1141; HMCBT. Grades: > 95%. CAS No. 38339-18-3. Molecular formula: C12H18Cl2N2O2. Mole weight: 293.19. | |
| Indanomycin | Indanomycin is an antibiotic of the pyrroloketoindane class produced by Streptomyces sp. It is an unusual pyrollic ionophore that is active against gram-positive bacteria and insects. It has antihypertensive properties. It is a growth promoter in ruminants. Synonyms: X-14547A; X 14547A; 2H-Pyran-2-acetic acid, 6-(1-ethyl-4-(1-ethyl-2,3,3a,4,5,7a-hexahydro-4-(1H-pyrrol-2-ylcarbonyl)-1H-inden-5-yl)-1,3-butadienyl)tetrahydro-alpha, 5-dimethyl-, (1S-(1-alpha,3-alpha,beta,4-beta,5-beta(1E(2S*(S*),5R*,6S*),3E),7a-alpha))-; Antibiotic X-14547A. Grades: >95% by HPLC. CAS No. 66513-28-8. Molecular formula: C31H43NO4. Mole weight: 493.68. | |
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