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1,2,3,6-Tetrahydro-1,3-dimethyl-2,6-dioxo-N-(6-phenyl-3-pyridazinyl)-7H-purine-7-acetamide is a novel potent PORCN inhibitor that blocks the secretion and activity of all Wnts. Group: Biochemicals. Grades: Highly Purified. CAS No. 1638250-96-0. Pack Sizes: 10mg, 50mg. Molecular Formula: C19H17N7O3, Molecular Weight: 391.38. US Biological Life Sciences.
Heterocyclic Organic Compound. Alternative Names: PHENOL, 2-(1,1-DIMETHYLETHYL)-6-(1-METHYLETHYL)-4-(3-PYRIDAZINYLAMINO)-;2-(1,1-Dimethylethyl)-6-(1-methylethyl)-4-(3-pyridazinylamino)phenol. CAS No. 114548-84-4. Molecular formula: C17H23N3O. Mole weight: 285.38. Catalog: ACM114548844.
2-Bromo-1-(6-chloro-3-pyridazinyl)-Ethanone
2-Bromo-1-(6-chloro-3-pyridazinyl)-Ethanone is used to prepare amide derivatives as β3 adrenergic receptor agonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 359794-51-7. Pack Sizes: 10mg, 100mg. Molecular Formula: C6H4BrClN2O, Molecular Weight: 235.47. US Biological Life Sciences.
1-(2,6-Difluorobenzyl)-5-[(dimethylamino)methyl]-3-(6-methoxypyridazine-3-yl)-6-(4-nitrophenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione is an impurity of Relugolix, which is an orally administered gonadotropin-releasing hormone (GnRH) receptor antagonist used in the treatment of several hormone-responsive conditions, including uterine fibroids, advanced prostate cancer, and endometriosis. Synonyms: Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 1-[(2,6-difluorophenyl)methyl]-5-[(dimethylamino)methyl]-3-(6-methoxy-3-pyridazinyl)-6-(4-nitrophenyl)-; 1-[(2,6-Difluorophenyl)methyl]-5-[(dimethylamino)methyl]-3-(6-methoxy-3-pyridazinyl)-6-(4-nitrophenyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione; Relugolix Impurity 9. Grades: ≥95%. CAS No. 1589503-96-7. Molecular formula: C27H22F2N6O5S. Mole weight: 580.56.
A 582941 is a selective α7 nAChR partial agonist which is effetive for both rat and human α7 receptors (Ki = 10.8 and 16.7 nM respectively). Synonyms: A-582941; A 582941; A582941; Octahydro-2-methyl-5-(6-phenyl-3-pyridazinyl)-pyrrolo[3,4-c]pyrrole; (3aR,6aS)-2-methyl-5-(6-phenylpyridazin-3-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole. Grades: ≥98% by HPLC. CAS No. 848591-90-2. Molecular formula: C17H20N4. Mole weight: 280.37.
CLP 257
CLP 257 has been found to be a KCC2 K+-Cl- cotransporter activator and could alleviates hypersensitivity in rats with peripheral nerve injury. Synonyms: CLP 257; CLP-257; CLP257; (5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone. Grades: ≥98% by HPLC. CAS No. 1181081-71-9. Molecular formula: C14H14FN3O2S. Mole weight: 307.34.
Levosimendan
Bioactive enantiomer of racemate, Simendan. Positive inotropic agent with vasodilating activity. Cardiotonic. Group: Biochemicals. Alternative Names: [ [4- [ (4R) -1, 4, 5, 6-Terahydro-4-methyl-6-oxo-3-pyridazinyl] phenyl] hydrazono] propanedinitrile; (R)-Simendan; OR-1259; Simdax. Grades: Highly Purified. CAS No. 141505-33-1. Pack Sizes: 10mg, 50mg, 100mg, 250mg. Molecular Formula: C14H12N6O, Molecular Weight: 280.28. US Biological Life Sciences.
Worldwide
Levosimendan
Levosimendan is a calcium sensitizer acting through calcium-dependent binding to cardiac troponin C (cTnC). Uses: Vasodilator agents. Synonyms: [ [4- [ (4R) -1, 4, 5, 6-Terahydro-4-methyl-6-oxo-3-pyridazinyl] phenyl] hydrazono] propanedinitrile. Grades: >98%. CAS No. 141505-33-1. Molecular formula: C14H12N6O. Mole weight: 280.28.
Levosimendan
Levosimendan (Simsndan; OR-1259) is a calcium sensitiser used in the management of acutely decompensated congestive heart failure. Group: Inhibitors. Alternative Names: LEVOSIMENDAN;(R)-2-[[4-(1,4,5,6-TETRAHYDRO-4-METHYL-6-OXO-3-PYRIDAZINYL)PHENYL] HYDROZONO]PRO ; LevosimendanC14H12N60; (R) -Simendan; [ [4- [ (4R) -1, 4, 5, 6-Terahydro-4-methyl-6-oxo-3-pyridazinyl] phenyl] hydrazono] propanedinitrile; OR-1259; Simda; Mesoxalonitrile (-)-{p-[(R)-1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl}hydrazone. CAS No. 141505-33-1. Molecular formula: C14H12N6O. Mole weight: 280.28. Appearance: Solid. Purity: 0.9988. Canonical SMILES: O=C1C[C@@H] (C)C (C2=CC=C (N/N=C (C#N)/C#N)C=C2)=NN1. Catalog: ACM141505331.
LY-186126
LY 186126 is a potent cGI-PDE inhibitor. It exhibit reversible and high affinity binding to a single class of SaR binding sites. Synonyms: LY 186126; LY186126; LY-186126. 1,3-Dihydro-1,3,3-trimethyl-5-[(1,4,5,6-tetrahydro-4-methyl-6-oxopyridazin)-3-yl]-2H-indol-2-one;2H-Indol-2-one, 1,3-dihydro-1,3,3-trimethyl-5-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)-;1,3,3-Trimethyl-6-(4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl)indol-2-one. Grades: >98 %. CAS No. 100644-00-6. Molecular formula: C16H19N3O2. Mole weight: 285.34.
Matlystatin A
It is produced by the strain of Actinomadura atramentaria. It's a Type V collagenase inhibitor. It can inhibit type IV collagenase and type I collagenase with ID50 (μmol/L) of 0.3 and 1.2, respectively. It has anti-gram-positive bacteria effect. Synonyms: N-Acetyl-S-(4-(((hexahydro-2-(2-(2-(hydroxyamino)-2-oxoethyl)-1-oxoheptyl)-3-pyridazinyl)carbonyl)amino)-5-methyl-3-oxoheptyl)-L-cysteine; N-acetyl-S- (4- (2- (2- (2- (hydroxyamino) -2-oxoethyl) heptanoyl) hexahydropyridazine-3-carboxamido) -5-methyl-3-oxoheptyl) -L-cysteine. CAS No. 140626-94-4. Molecular formula: C27H47N5O8S. Mole weight: 601.76.
Matlystatin D
It is produced by the strain of Actinomadura atramentaria. It's a Type V collagenase inhibitor. It can inhibit type IV collagenase and type I collagenase with ID50 (μmol/L) of 3.64 and 28, respectively. Synonyms: Matlystatin D1; Pyrazolo(1,2-a)pyridazin-4-ium,8-carboxy-1-(1-(((hexahydro-2-(2-(2-(hydroyamino)-2-oxoethyl)-1-oxoheptyl)-3-pyridazinyl)carbonyl)amino)-2-methylbutyl)-5,6,7,8-tetrahydro-,hydroxide,inner salt; [(3-{6-[{[1-(8-Carboxy-5,6,7,8-tetrahydropyrazolo[1,2-a]pyridazin-9-ium-1-yl)-2-methylbutyl]imino}(hydroxy)methyl]-1,2-diazinane-1-carbonyl}-1-hydroxyoctylidene)amino]oxidanide. CAS No. 140638-25-1. Molecular formula: C27H44N6O6. Mole weight: 548.68.
Matlystatin E
It is produced by the strain of Actinomadura atramentaria. It's a Type V collagenase inhibitor. It can inhibit type IV collagenase and type I collagenase with ID50 (μmol/L) of 19.3 and 59, respectively. Synonyms: Matlystatin E1; Pyrazolo(1,2-a)pyridazin-4-ium,8-carboxy-1-(1-(((hexahydro-2-(2-(2-(hydroxyamino)-2-oxoethyl)-1-oxohexyl)-3-pyridazinyl)carbonyl)amino)-2-methylbutyl)-5,6,7,8-tetrahydro-,hydroxide,inner salt; [(3-{6-[{[1-(8-Carboxy-5,6,7,8-tetrahydropyrazolo[1,2-a]pyridazin-9-ium-1-yl)-2-methylbutyl]imino}(hydroxy)methyl]-1,2-diazinane-1-carbonyl}-1-hydroxyheptylidene)amino]oxidanide. CAS No. 140638-26-2. Molecular formula: C26H42N6O6. Mole weight: 534.65.
Matlystatin F
It is produced by the strain of Actinomadura atramentaria. It's a Type V collagenase inhibitor. It can inhibit type IV collagenase and type I collagenase with ID50 (μmol/L) of 1.82 and 5.1, respectively. Synonyms: Matlystatin F1; Pyrazolo(1,2-a)pyridazin-4-ium,5-carboxy-1-(1-(((hexahydro-2-(2-(2-(hydroyamino)-2-oxoethyl)-1-oxoheptyl)-3-pyridazinyl)carbonyl)amino)-2-methylbutyl)-5,6,7,8-tetrahydro-,hydroxide,inner salt; [(3-{6-[{[1-(5-Carboxy-5,6,7,8-tetrahydropyrazolo[1,2-a]pyridazin-9-ium-1-yl)-2-methylbutyl]imino}(hydroxy)methyl]-1,2-diazinane-1-carbonyl}-1-hydroxyoctylidene)amino]oxidanide. CAS No. 140667-42-1. Molecular formula: C27H44N6O6. Mole weight: 548.68.
Nifurprazine
Nifurprazine residues in body fluids and tissues of cattle following intrycysternal administration. Synonyms: (E)-6-(3-(5-Nitro-2-furyl)vinyl)-3-pyridazinylamin; 3-Amino-6-((5-nitro-2-furil)-vinil)-1,2-diazina; 3-Amino-6-((5-nitro-2-furil)-vinil)-1,2-diazina [Italian]; 3-Amino-6-(2-(5-nitro-2-furyl)vinyl)pyradizine; 3-Amino-6-(2-(5-nitro-2-furyl)vinyl)pyridazine. Grades: > 95%. CAS No. 1614-20-6. Molecular formula: C10H8N4O3. Mole weight: 232.2.
R 77975. Group: Biochemicals. Alternative Names: 4- [2- [1- (6-Methyl-3-pyridazinyl) -4-piperidinyl] ethoxy] benzoic Acid Ethyl Ester;Ethyl 4- [2- [1- (6-Methyl-3-pyridazinyl) -4-piperidinyl] ethoxy] benzoate; Pirodavir. Grades: Highly Purified. CAS No. 124436-59-5. Pack Sizes: 10mg. Molecular Formula: C21H27N3O3, Molecular Weight: 369.46. US Biological Life Sciences.
Worldwide
Relugolix
Relugolix, also known as TAK-385, is a luteinizing hormone-releasing hormone (LH-RH) receptor antagonist administered orally. By preventing LH-RH from binding with the LH-RH receptor in the anterior pituitary gland and suppressing the secretion of luteinizing hormone (LH) and follicle stimulation hormone (FSH) from the anterior pituitary gland, TAK-385 controls the effect of LH and FSH on the ovary, reduces the level of estrogen in blood, which is known to be associated with the development of endometriosis and uterine fibroids, and is expected to improve the symptoms of these disorders. Uses: Androgen antagonists. Synonyms: TAK-385; N-[4-[1-[(2,6-Difluorophenyl)methyl]-5-[(dimethylamino)methyl]-1,2,3,4-tetrahydro-3-(6-methoxy-3-pyridazinyl)-2,4-dioxothieno[2,3-d]pyrimidin-6-yl]phenyl]-N'-methoxyurea; Orgovyx; RVT 601; 1-{4-[1-(2,6-difluorobenzyl)-5-dimethylaminomethyl-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea. Grades: ≥95%. CAS No. 737789-87-6. Molecular formula: C29H27F2N7O5S. Mole weight: 623.63.
RGW2938
A phosphodiesterase inhibitor. Synonyms: RGW2938; RGW 2938; RGW-2938; 2(1H)?-Quinazolinone, 3,?4-dihydro-3-methyl-6-(1,?4,?5,?6-tetrahydro-6-oxo-3-pyridazinyl)?-. CAS No. 111786-07-3. Molecular formula: C13H14N4O2. Mole weight: 258.28.
A metabolite of Levosimendan. Group: Biochemicals. Alternative Names: (R)-N-[4-(1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-acetamide; OR-1896. Grades: Highly Purified. CAS No. 220246-81-1. Pack Sizes: 5mg. US Biological Life Sciences.
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SAR 216471 hydrochloride
SAR 216471 hydrochloride is a potent and reversible P2Y12 antagonist (IC50 = 17 nM), displaying antiplatelet and antithrombotic activity in vivo. Synonyms: SAR 216471 hydrochloride; SAR-216471 hydrochloride; SAR216471 hydrochloride; 5-Chloro-N-[6-[5-methyl-4-(1-oxobutyl)-1H-pyrazol-1-yl]-3-pyridazinyl]-1-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 1279829-64-9. Molecular formula: C28H31ClN8O3.HCl. Mole weight: 599.51.
Siguazodan
Siguazodan is a selective phosphodiesterase 3 (PDE3) inhibitor (IC50 = 117 nM). Siguazodan acts as a potent vasodilator. Uses: Vasodilator. Synonyms: N-Cyano-N'-methyl-N''-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]guanidine; SKF 94836; SKF-94836; SKF94836. Grades: ≥99% by HPLC. CAS No. 115344-47-3. Molecular formula: C14H16N6O. Mole weight: 284.32.
Sulfachlorpyridazine
Sulfachlorpyridazine. Group: Biochemicals. Alternative Names: 4-Amino-N-(6-chloro-3-pyridazinyl)-benzenesulfonamide; 3-Chloro -6-sulfanilamidopyridazin e; Sulfaclorazina. Grades: Highly Purified. CAS No. 80-32-0. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C10H9ClN4O2S. US Biological Life Sciences.
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Sulfachlorpyridazine Sodium
Sulfachlorpyridazine is an antibacterial compound. Group: Biochemicals. Alternative Names: 4-Amino-N-(6-chloro-3-pyridazinyl)-benzenesulfonamide Sodium; 3-Chloro -6-sulfanilamidopyridazin e Sodium; N1- (6-Chloro-3-pyridazinyl) sulfanilamide Monosodium Salt; Prinzone; Sodium Sulfachloropyridazine; Sodium Sulfachlorpyridazine; Sulfachloropyridazine Sodium; Sulfachlorpyridazine Sodium Salt; Vetisulid. Grades: Highly Purified. CAS No. 23282-55-5. Pack Sizes: 100mg. US Biological Life Sciences.
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Sulfaethoxypyridazine
Sulfaethoxypyridazine. Group: Biochemicals. Alternative Names: Sulfanilamido-6-ethoxy-3-pyridazine; N1- (6-Ethoxy-3-pyridazinyl) sulfanilamide; Cysul; 4-amino-N- (6-ethoxy-3-pyridazinyl) benzenesulfonamide. Grades: Highly Purified. CAS No. 963-14-4. Pack Sizes: 100mg. Molecular Formula: C12H14N4O3S, Molecular Weight: 294.33. US Biological Life Sciences.
Worldwide
Sulfaethoxypyridazine-d5
Sulfaethoxypyridazine-d5. Group: Biochemicals. Alternative Names: Sulfanilamido-6-ethoxy-3-pyridazine-d5; N1- (6-Ethoxy-3-pyridazinyl) sulfanilamide-d5; Cysul-d5; 4-amino-N- (6-ethoxy-3-pyridazinyl) benzenesulfonamide-d5. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C12H9D5N4O3S, Molecular Weight: 299.36. US Biological Life Sciences.
Worldwide
Sulfamethoxypyridazine
Sulfamethoxypyridazine . Group: Biochemicals. Alternative Names: 4-Amino-N-(6-methoxy-3-pyridazinyl)-benzenesulfonamide; 3-Methoxy-6-sulfanilamidopyridazin e; 6-Sulfanilamido-3-methoxypyridazine. Grades: Highly Purified. CAS No. 80-35-3. Pack Sizes: 5g, 10g, 25g, 50g, 100g. Molecular Formula: C11H12N4O3S. US Biological Life Sciences.
Worldwide
Sulfamethoxypyridazine
Sulfamethoxypyridazine is a long-acting sulfonamide antibiotic. It is used for treatment of Dermatitis herpetiformis. Uses: Sulfamethoxypyridazine is used for treatment of dermatitis herpetiformis. Synonyms: Sulfanilamide, N1-(6-methoxy-3-pyridazinyl)-; Sulfdurazin; Sulfozona; Sultirene; Surirene; Sulfalex; 4-amino-N-(6-methoxypyridazin-3-yl)benzenesulfonamide; 3-Sulfanilamido-6-methoxypyridazine; 6-Methoxy-3-pyridazinylsulfanilamide; 6-Sulfanilamido-3-methoxypyridazine; Altezol; Davosin; Davozil; Depovernil; Kinex; Kynex; Lederkin; Lederkyn; Longin; Midicel; Myasul; Paramid; Piridolo. Grades: >98.0%(LC). CAS No. 80-35-3. Molecular formula: C11H12N4O3S. Mole weight: 280.30.
TAK 21d is a potent and brain penetrating FAAH inhibitor (IC50 = 0.28 and 0.72 nM at rat and human FAAH, respectively). TAK 21d exhibits analgesic effects in vivo models of neuropathic and inflammatory pain. Synonyms: TAK-21d; TAK 21d; TAK21d; TAK-21-d; 4-[4-(3,4-Difluorophenyl)-2-pyrimidinyl]-N-3-pyridazinyl-1-piperazinecarboxamide. Grades: ≥98% by HPLC. CAS No. 1143578-94-2. Molecular formula: C19H17F2N7O. Mole weight: 397.38.
Vapendavir
Vapendavir is an orally active capsid-binding inhibitor as a capsid binderwith potent anti-rhinoviral activity and broad serotype coverage. Uses: Rhinovirus replication inhibitor. Synonyms: Vapendavir; BTA-798; BTA798; BTA 7983-Ethoxy-6-[2-[1-(6-methyl-3-pyridazinyl)-4-piperidinyl]ethoxy]-1,2-benzisoxazole. Grades: ≥95%. CAS No. 439085-51-5. Molecular formula: C21H26N4O3. Mole weight: 382.46.
VU-0240551
VU 0240551 is a small-molecule inhibitor of neuronal K-Cl cotransporter(KCC2) with IC50 value of 560nM, which is a potassium-chloride exchanger expressed specifically in neurons. It also inhibits hERG and L-type Ca2+ channels. It is primarily responsible for maintaining intracellular Cl- concentrations including regulating an excess or lack of ions following periods of under or overstimulation, as well as general dendritic development. It was discovered in a high-throughput screen, followed by directed medicinal chemistry. It is selective for KCC2 and shows minimal effect on NKCC1. It binds competitively to the K+ site and binds noncompetitively to the Cl- site. It is the only small molecule with specificity for a KCC family member. It significantly inhibits KCC2-mediated K+ uptake at concentration of 10μM. It is also found to inhibit KCC3 in the micromolar range. It exerts significant effects on Adenosine A1 and A3 receptors, L- type Ca2+ channel and K+ channel hERG when treated with some other GPCRs, ion channels and transporters. Uses: Vu 0240551 is primarily responsible for maintaining intracellular cl- concentrations including regulating an excess or lack of ions following periods of under or overstimulation, as well as general dendritic development. Synonyms: VU0240551, VU 0240551, VU- 0240551; N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide;VU 0240551. Grades: >99 %. CAS No. 893990-34-6. Molecular formula: C16H14N4OS2. Mole weight: 342.43.
VU 0463271
VU 0463271 is a potent and selective inhibitor of KCC2, which is a neuronal K-Cl cotransporter (IC50 = 61 nM). VU 0463271 exhibits >100-fold selectivity versus the Na-K-2Cl cotransporter 1 (NKCC1) and no activity against a panel of 68 GPCRs, ion channels and transporters. Synonyms: VU0463271; VU-0463271; VU 0463271; N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide. Grades: ≥98% by HPLC. CAS No. 1391737-01-1. Molecular formula: C19H18N4OS2. Mole weight: 382.5.
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