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| Product | Description | |
|---|---|---|
| retinal dehydrogenase | A metalloflavoprotein (FAD). Acts on both the 11-trans- and 13-cis-forms of retinal. Group: Enzymes. Synonyms: cytosolic retinal dehydrogenase. Enzyme Commission Number: EC 1.2.1.36. CAS No. 37250-99-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1141; retinal dehydrogenase; EC 1.2.1.36; 37250-99-0; cytosolic retinal dehydrogenase. Cat No: EXWM-1141. |  |
| Retinal dehydrogenase 1 (88-96) | Retinal dehydrogenase 1 (88-96) is a 9-aa peptide. Retinal dehydrogenase 1 can convert/oxidize retinaldehyde to retinoic acid. Synonyms: RALDH 1 (88-96); Aldehyde dehydrogenase family 1 member A1 (88-96). |  |
| Retinal Microvascular Endothelial Cells, Human (Frozen) | Passage 3 cells are shipped in proliferating culture with a confluence of >90%. ENDO-Growth medium containing 5% serum and growth supplement is recommended for culture. Cells have an average population doubling level of >16 when cultured. Group: Biologicals. Grades: Cell Culture Grade. Pack Sizes: 1ml. US Biological Life Sciences. |  Worldwide |
| Retinal Microvascular Endothelial Cells, Human (T-25 flask) | Passage 3 cells are shipped in proliferating culture with a confluence of >90%. ENDO-Growth medium containing 5% serum and growth supplement is recommended for culture. Cells have an average population doubling level of >16 when cultured. Group: Biologicals. Grades: Cell Culture Grade. Pack Sizes: T-25 flask. US Biological Life Sciences. | Worldwide |
| 11-cis-3,4-Didehydro Retinal | 11-cis-3,4-Didehydro Retinal is an isomer of Retinal (R240000) used in vision restoration and reconstitution treatments. Group: Biochemicals. Alternative Names: 11-cis-3-Dehydroretinal; 11-cis-Retinal2; 3,4-Dehydro-11-cis-retinal; Retinal2. Grades: Highly Purified. CAS No. 41470-05-7. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| 13-cis-Retinal | 13-cis-Retinal. Group: Biochemicals. Alternative Names: 13-cis-Retinaldehyde; 13Z-Retinal; Neoretinene a. Grades: Highly Purified. CAS No. 472-86-6. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C20H28O. US Biological Life Sciences. | Worldwide |
| 13-cis-Retinal-14,15-13C2 | An isomer of labeled all-trans-Retinal. Group: Biochemicals. Alternative Names: 13-cis-Retinaldehyde-14,15-13C2; 13Z-Retinal-14,15-13C2; Neovitamin A Aldehyde-14,15-13C2. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 3-Dehydro Retinal | An oxidized derivative of the visual pigment carotenoid. Group: Biochemicals. Alternative Names: (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1,3-cyclohexadien-1-yl)-2,4,6,8-nonatetraenal; trans-3-Dehydroretinal; Dehydroretinaldehyde; Retinene 2; Vitamin A2 Aldehyde. Grades: Highly Purified. CAS No. 472-87-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 4-Keto retinal | 4-Keto retinal. Group: Biochemicals. Alternative Names: 9-(2,6,6-Trimethyl-3-keto-1-cyclohexen-1-yl)-3,7-dimethyl-2,4,6,8-nonatetraen-1-al; 4-Oxo-all-trans-retinal; 4-Oxoretinal. Grades: Highly Purified. CAS No. 33532-44-4. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C20H26O2. US Biological Life Sciences. | Worldwide |
| 4-Keto Retinal | . Uses: An inactive catabolite of retinoic acid. Synonyms: (2E,4E,6E,8E)-9-(2,6,6-Trimethyl-3-keto-1-cyclohexen-1-yl)-3,7-dimethyl-2,4,6,8-nonatetraen-1-al; 4-Oxo-all-trans-retinal; 4-Oxoretinal; all-trans-4-Oxoretinal. Grades: 96%. CAS No. 33532-44-4. Molecular formula: C20H26O2. Mole weight: 298.42. | |
| 9-cis-Retinal | 9-cis-Retinal. Group: Biochemicals. Alternative Names: 9-Z-Retinal; 9-cis-Retinaldehyde; 9-cis-Vitamin A aldehyde. Grades: Highly Purified. CAS No. 514-85-2. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C20H28O. US Biological Life Sciences. | Worldwide |
| 9-cis-Retinal | 9-cis-Retinal is a natural retinoid. Dietary 9-cis-β-carotene generates 9-cis-retinoids via cleavage into 9-cis-retinal. 9-cis Retinal binds to cellular retinol-binding protein-I (CRBP-I) and CRBP-II with K d s of 8 nM and 5 nM, respectively. 9-cis-Retinal expedites differentiation and maturation of rod photoreceptors in retinal organoids [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 514-85-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-W009310. |  |
| 9-cis Retinal (9-cis-Retinaldehyde, 9-cis-Vitamin A aldehyde, Isoretinene a) | Atmosphere: Group: Biochemicals. Alternative Names: 9-cis-Retinaldehyde, 9-cis-Vitamin A aldehyde, Isoretinene a. Grades: Highly Purified. CAS No. 514-85-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| all trans-Retinal | All-trans retinal is converted to retinoic acid in vivo by the action of retinal dehydrogenase. Synonyms: (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenal. Grades: > 95 %. CAS No. 116-31-4. Molecular formula: C20H28O. Mole weight: 284.44. | |
| All-trans-retinal | All-trans-retinal is an vitamin A metabolite in the retina, and is produced following photo-isomerization of the visual chromophore 11-cis-Retinal. All-trans-retinal is cleared from photoreceptors by ATP-binding cassette transporter (ABCA4) and all-trans-retinol dehydrogenase (RDH). All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis [1]. Uses: Scientific research. Group: Natural products. CAS No. 116-31-4. Pack Sizes: 100 mg. Product ID: HY-W004500. | |
| All-trans-retinal | Heterocyclic Organic Compound. Alternative Names: Axerophthal. CAS No. 116-31-4. Molecular formula: C20H28O. Mole weight: 284.44. Appearance: Yellow powder. Purity: 98%+. IUPACName: (2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenal. Canonical SMILES: CC1=C (C (CCC1) (C)C)C=CC (=CC=CC (=CC=O)C)C. Density: 1.0083 g/cm³. Catalog: ACM116314. |  |
| All-trans-Retinal | 100mg Pack Size. Group: Analytical Reagents, Biochemicals, Flavours and Fragrance Materials. Formula: C20H28O. CAS No. 116-31-4. Prepack ID 52326571-100mg. Molecular Weight 284.44. See USA prepack pricing. |  |
| All-trans-Retinal | 1g Pack Size. Group: Analytical Reagents, Biochemicals, Flavours and Fragrance Materials. Formula: C20H28O. CAS No. 116-31-4. Prepack ID 52326571-1g. Molecular Weight 284.44. See USA prepack pricing. | |
| all-trans-Retinal-d5 | Corotenoid component of the visual pigments. Group: Biochemicals. Alternative Names: (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenal-d5. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| all-trans Retinal (Vitamin A Aldehyde, Retinene, Retinylaldehyde) | Corotenoid component of the visual pigments. All-trans retinal is converted to retinoic acid in vivo by the action of retinal dehydrogenase. Group: Biochemicals. Alternative Names: (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenal; all -trans-Vitamin A Aldehyde; Retinene; Retinylaldehyde. Grades: Highly Purified. CAS No. 116-31-4. Pack Sizes: 500mg, 1g. US Biological Life Sciences. | Worldwide |
| GFP Expressing Retinal Microvascular Endothelial Cells, Human (Frozen) | Puromycin resistant GFP-HRMECs were selected and shipped in proliferating culture with >90% confluence (cells are provided at passage 4-5). ENDO-Growth medium containing 5% serum and growth supplement is recommended for cell culture. Cells have an average population doubling level of >16 when cultured. Group: Biologicals. Grades: Cell Culture Grade. Pack Sizes: 1ml. US Biological Life Sciences. | Worldwide |
| GFP Expressing Retinal Microvascular Endothelial Cells, Human (T-25 flask) | Puromycin resistant GFP-HRMECs were selected and shipped in proliferating culture with >90% confluence (cells are provided at passage 4-5). ENDO-Growth medium containing 5% serum and growth supplement is recommended for cell culture. Cells have an average population doubling level of >16 when cultured. Group: Biologicals. Grades: Cell Culture Grade. Pack Sizes: T-25 flask. US Biological Life Sciences. | Worldwide |
| GFP Expressing Retinal Microvascular Pericytes, Human (Frozen) | Puromycin resistant GFP-HRMPs were selected and shipped in proliferating culture with >90% confluence (cells are provided at passage 3-5). Pericyte growth medium containing FBS and growth supplement is recommended for cell culture. Cells have an average population doubling level of >10 when cultured. Group: Biologicals. Grades: Cell Culture Grade. Pack Sizes: 1ml. US Biological Life Sciences. | Worldwide |
| GFP Expressing Retinal Microvascular Pericytes, Human (T-25 flask) | Puromycin resistant GFP-HRMPs were selected and shipped in proliferating culture with >90% confluence (cells are provided at passage 3-5). Pericyte growth medium containing FBS and growth supplement is recommended for cell culture. Cells have an average population doubling level of >10 when cultured. Group: Biologicals. Grades: Cell Culture Grade. Pack Sizes: T-25 flask. US Biological Life Sciences. | Worldwide |
| rac 11-cis-3-hydroxy retinal | rac 11-cis-3-hydroxy retinal. Group: Biochemicals. Alternative Names: 11-cis-3-Hydroxyretinal; Retinal3; 3-Hydroxy-11-cis-retinal. Grades: Highly Purified. CAS No. 102918-00-3. Pack Sizes: 25mg. Molecular Formula: C20H28O2. US Biological Life Sciences. | Worldwide |
| rac all-trans 4-Hydroxy retinal | rac all-trans 4-Hydroxy retinal. Group: Biochemicals. Alternative Names: 4-Hydroxyretinal. Grades: Highly Purified. CAS No. 18344-42-8. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C20H28O2. US Biological Life Sciences. | Worldwide |
| RFP Expressing Retinal Microvascular Endothelial Cells, Human (Frozen) | Zeocin resistant RFP-HRMECs were selected and shipped in proliferating culture with a confluence of >90% (cells are provided at passage 4-5). ENDO-Growth medium containing 5% serum and growth supplement is recommended for cell culture. Cells have an average population doubling level of >16 when cultured. Group: Biologicals. Grades: Cell Culture Grade. Pack Sizes: 1ml. US Biological Life Sciences. | Worldwide |
| RFP Expressing Retinal Microvascular Endothelial Cells, Human (T-25 flask) | Zeocin resistant RFP-HRMECs were selected and shipped in proliferating culture with a confluence of >90% (cells are provided at passage 4-5). ENDO-Growth medium containing 5% serum and growth supplement is recommended for cell culture. Cells have an average population doubling level of >16 when cultured. Group: Biologicals. Grades: Cell Culture Grade. Pack Sizes: T-25 flask. US Biological Life Sciences. | Worldwide |
| 11,12-Didehydro Retinol | 11-cis Retinal intermediate. Group: Biochemicals. Alternative Names: 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,6,8-nonatrien-4-yn-1-ol; 11,12-Didehydroretinol. Grades: Highly Purified. CAS No. 29443-88-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 11-cis-retinol dehydrogenase | This enzyme, abundant in the retinal pigment epithelium, catalyses the reduction of 11-cis-retinol to 11-cis-retinal while the substrate is bound to the retinal-binding protein. This is a crucial step in the regeneration of 11-cis-retinal, the chromophore of rhodopsin. The enzyme can also accept other cis forms of retinol. Group: Enzymes. Synonyms: RDH5 (gene name). Enzyme Commission Number: EC 1.1.1.315. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0227; 11-cis-retinol dehydrogenase; EC 1.1.1.315; RDH5 (gene name). Cat No: EXWM-0227. | |
| 13-cis-Retinonitrile-13C2 | An isomer of a labeled all-trans-Retinal intermediate. Group: Biochemicals. Alternative Names: (2E,4E,6E,8Z)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenenitrile-13C2. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 15,15'-cis- β, β-Carotene | 15,15'-cis- β, β-Carotene is a very powerful antioxidant and a precursor to Vitamin A which is an essential nutrient, required by the retina of the eye in the form of a specific metabolite, the light-absorbing molecule retinal, that is necessary for both low-light (scotopic vision) and color vision. As a part of the carotenoid family of compounds it is a very effective scavenger and quencher of singlet oxygen and free radicals. Prooxidant. Group: Biochemicals. Grades: Highly Purified. CAS No. 19361-58-1. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C40H56, Molecular Weight: 536.87. US Biological Life Sciences. | Worldwide |
| 2,4-Dichloro-1-(4-nitrophenoxy)benzene | 2,4-Dichloro-1-(4-nitrophenoxy)benzene (Nitrofen) is a diphenyl ether that induces congenital diaphragmatic hernia (CDH) in rodents. It induces apoptosis independently of retinaldehyde dehydrogenase (RALDH) inhibition. Group: Biochemicals. Grades: Highly Purified. CAS No. 1836-75-5. Pack Sizes: 5g, 25g. Molecular Formula: C12H7Cl2NO3, Molecular Weight: 284.089999999999. US Biological Life Sciences. | Worldwide |
| (2E)-4-Chloro-3-methyl-2-butenenitrile | (2E)-4-Chloro-3-methyl-2-butenenitrile in an intermediate used in the synthesis of all-trans-Retinal-d5 (R240002), which is corotenoid component of the visual pigments. Group: Biochemicals. Grades: Highly Purified. CAS No. 25163-39-7. Pack Sizes: 250mg, 500mg. Molecular Formula: C5H6ClN, Molecular Weight: 115.56. US Biological Life Sciences. | Worldwide |
| (2E,4E)-3-Methyl-5-(2,6,6-trimethyl-1,3-cyclohexadien-1-yl)-2,4-pentadienal | (2E,4E)-3-Methyl-5-(2,6,6-trimethyl-1,3-cyclohexadien-1-yl)-2,4-pentadienal is an intermediate in the synthesis of Vitamin A2 series and isomers of Retinal (R240000) for the potential use in vision restoration and reconstitution treatments. Group: Biochemicals. Grades: Highly Purified. CAS No. 25528-87-4. Pack Sizes: 2.5mg, 10mg. Molecular Formula: C15H20O. US Biological Life Sciences. | Worldwide |
| (2E,4E)-3-Methyl-5-(2,6,6-trimethyl-1,3-cyclohexadien-1-yl)-2,4-pentadienenitrile | (2E,4E)-3-Methyl-5-(2,6,6-trimethyl-1,3-cyclohexadien-1-yl)-2,4-pentadienenitrile is an intermediate in the synthesis of Vitamin A2 series and isomers of Retinal (R240000) for the potential use in vision restoration and reconstitution treatments. Group: Biochemicals. Grades: Highly Purified. CAS No. 20109-91-5. Pack Sizes: 2.5mg, 10mg. Molecular Formula: C15H19N. US Biological Life Sciences. | Worldwide |
| 3-Methoxy-2-methylacetanilide | Intermediate in the preparation of indole-based derivatives as protecting agents for retinal neuronal cells. Group: Biochemicals. Alternative Names: N-(3-Methoxy-2-methylphenyl)-acetamide. Grades: Highly Purified. CAS No. 50868-74-1. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
| 3- [ [ (tert-Butyl) dimethylsilyl] oxy] retinoic Acid Ethyl Ester | Intermediate in the preparation of hydroxyretinals. Group: Biochemicals. Alternative Names: 3- [ [ (1, 1-Dimethylethyl) dimethylsilyl] oxy] retinoic Acid Ethyl Ester. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| (4E)-5-(4-Methoxy-2,3,6-trimethylphenyl)-3-methyl-2,4-pentadienal (cis/trans Mixture) | An intermediate for the synthesis of aromatic analogs of retinal and retinoic acid. Group: Biochemicals. Grades: Highly Purified. CAS No. 419534-29-5. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| (4E)-5-(4-Methoxy-d3-2,3,6-trimethylphenyl)-3-methyl-2,4-pentadienal | An intermediate for the synthesis of aromatic analogs of retinal and retinoic acid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| 5-O-Methyl Quercetin | O-Methylated analogue of the flavanoid Quercertin. It is a small molecule inhibitor of NADPH Oxidase 4 enzyme. It is used in studies of flavonoid structure requirement for the increment of ocular blood flow in the rabbit and retinal function recovery in rat eyes. Group: Biochemicals. Alternative Names: 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-5-methoxy-4H-1-benzopyran-4-one; 3,3',4,7-Tetrahydroxy-5-methoxyflavone; Azaleatin; Quercetin 5-Methyl Ether. Grades: Highly Purified. CAS No. 529-51-1. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 8-pCPT-PET-cGMP | 8-pCPT-PET-cGMP is an activator of cyclic GMP-dependent protein kinase as well as an inhibitor of the retinal type cGMP-gated ion channel, thus it can be used for distinction between kinase and ion channel mediated effects. It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Compared to 8-Br-PET-cGMP, 8-pCPT-PET-cGMP is much more lipophilic and membrane-permeant. Synonyms: 8- (4- Chlorophenylthio)- β- phenyl- 1, N2- ethenoguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grades: ≥ 98% by HPLC. Molecular formula: C24H18ClN5O7PS · Na. Mole weight: 609.9. | |
| 9-cis-13,14-Dihydro 13-Methylretinoic Acid | 9-cis-13,14-Dihydroretinoic Acid is a derivative of Retinal. Synonyms: (4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-4,6,8-trienoic acid; (9-cis)-13,14-Dihydroretinoic acid. Grades: 80%. CAS No. 176019-01-5. Molecular formula: C20H30O2. Mole weight: 302.45. | |
| 9-cis Retinol Acetate | A retinal derivative for treatment of visual disorders. Uses: Adjuvants, immunologic. Synonyms: 9-cis-Retinyl Acetate; 9-cis-Vitamin A Acetate; 9-cis-Vitamin A1 Acetate. Grades: > 95%. CAS No. 29584-22-3. Molecular formula: C22H32O2. Mole weight: 328.5. | |
| 9-cis-Retinol Acetate | Retinal derivative for treatment of visual disorders. Group: Biochemicals. Alternative Names: 9-cis-Retinyl Acetate; 9-cis-Vitamin A Acetate; 9-cis-Vitamin A1 Acetate. Grades: Highly Purified. CAS No. 29584-22-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| ACETYLSEROTONIN, N- | N-Acetyl-Serotonin is an agonist at melatonin receptors. It has also shown antidepressant activity and some effectiveness in treating retinal degenerative diseases. Group: Alkaloids. CAS No. 1210-83-9. Mole weight: 218.26. Appearance: White to off white powder. ECNumber: 214-916-5. Catalog: ACM1210839-1. | |
| alcohol dehydrogenase [NAD(P)+] | Reduces aliphatic aldehydes of carbon chain length from 2 to 14, with greatest activity on C4, C6 and C8 aldehydes; also reduces retinal to retinol. Group: Enzymes. Synonyms: retinal reductase (ambiguous); aldehyde reductase (NADPH/NADH); alcohol dehydrogenase [NAD(P)]. Enzyme Commission Number: EC 1.1.1.71. CAS No. 37250-10-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0355; alcohol dehydrogenase [NAD(P)+]; EC 1.1.1.71; 37250-10-5; retinal reductase (ambiguous); aldehyde reductase (NADPH/NADH); alcohol dehydrogenase [NAD(P)]. Cat No: EXWM-0355. | |
| aldehyde oxidase | Contains molybdenum, [2Fe-2S] centres and FAD. The enzyme from liver exhibits a broad substrate specificity, and is involved in the metabolism of xenobiotics, including the oxidation of N-heterocycles and aldehydes and the reduction of N-oxides, nitrosamines, hydroxamic acids, azo dyes, nitropolycyclic aromatic hydrocarbons, and sulfoxides.The enzyme is also responsible for the oxidation of retinal, an activity that was initially attributed to a distinct enzyme (EC 1.2.3.11, retinal oxidase). Group: Enzymes. Synonyms: quinoline oxidase; retinal oxidase. Enzyme Commission Number: EC 1.2.3.1. CAS No. 9029-7-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1206; aldehyde oxidase; EC 1.2.3.1; 9029-07-6; quinoline oxidase; retinal oxidase. Cat No: EXWM-1206. | |
| A-Leb-heptasaccharide | A-Leb-heptasaccharide is a biomedical compound used in the research of Leber congenital amaurosis (LCA), a rare inherited retinal degenerative disease. Molecular formula: C46H78N2O34. Mole weight: 1203.10. | |
| all-trans-8'-apo-β-carotenal 15,15'-oxygenase | Contains an Fe2+-4His arrangement. The enzyme is involved in retinal biosynthesis in bacteria. Group: Enzymes. Synonyms: Diox1; ACO; 8'-apo-β-carotenal 15,15'-oxygenase. Enzyme Commission Number: EC 1.13.11.75. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0595; all-trans-8'-apo-β-carotenal 15,15'-oxygenase; EC 1.13.11.75; Diox1; ACO; 8'-apo-β-carotenal 15,15'-oxygenase. Cat No: EXWM-0595. | |
| All-trans Retinol | Vitamin A is a group of unsaturated nutritional organic compounds, which includes retinol, retinal, retinoic acid, several provitamin A carotenoids, and beta-carotene. Vitamin A is important for growth and development, for the maintenance of the immune system and good vision. Vitamin A is needed by the retina of the eye in the form of retinal, which combines with protein opsin to form rhodopsin, the light-absorbing molecule necessary for both low-light (scotopic vision) and color vision. Vitamin A also functions in a very different role as retinoic acid (an irreversibly oxidized form of retinol), which is an important hormone-like growth factor for epithelial and other cells. Uses: Vitamin a is indicated only for prevention or treatment of vitamin a deficiency states. Synonyms: Vitamin A; Vitamin A1; (all-e)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol; 2,4,6,8-Nonatetraen-1-ol, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (all-E)-; 21 CFR 182,5930; 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclchexen-1-yl)-2,4,6,8-nonate. Grades: >98%. CAS No. 68-26-8. Molecular formula: C20H30O. Mole weight: 286.46. | |
| all-trans-retinol dehydrogenase (NAD+) | The enzyme recognizes all-trans-retinol and all-trans-retinal as substrates and exhibits a strong preference for NAD+/NADH as cofactors. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form. No activity with 11-cis-retinol or 11-cis-retinal (cf. EC 1.1.1.315, 11-cis retinol dehydrogenase). Also active with 3α-hydroxysteroids. Group: Enzymes. Synonyms: retinol (vitamin A1) dehydrogenase; MDR; microsomal retinol dehydrogenase; retinol dehydrogenase (misleading); retinal reductase (ambiguous); retinene reductase; epidermal retinol dehydrogenase 2; SDR16C5 (gene name); RDH16 (gene name). Enzyme Commission Number: EC 1.1.1.105. CAS No. 9033-53-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0008; all-trans-retinol dehydrogenase (NAD+); EC 1.1.1.105; 9033-53-8; retinol (vitamin A1) dehydrogenase; MDR; microsomal retinol dehydrogenase; retinol dehydrogenase (misleading); retinal reductase (ambiguous); retinene reductase; epidermal retinol dehydrogenase 2; SDR16C5 (gene name); RDH16 (gene name). Cat No: EXWM-0008. | |
| all-trans-Retinonitrile-14,15-13C2 | Labeled Retinal intermediate. Group: Biochemicals. Alternative Names: (2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenenitrile-14,15-13C2; all-trans-Vitamin A Nitrile-14,15-13C2. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| all-trans-Retinoyl Fluoride | all-trans-Retinoyl Fluoride is an intermediate used in the synthesis of all-trans Retinoyl β-D-Glucuronide, which is a biliary metabolite of Vitamin A. Synonyms: Retinoyl Fluoride; 15-Fluororetinal; Retinoyl fluoride (all-trans); (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoyl fluoride. CAS No. 83802-77-1. Molecular formula: C20H27FO. Mole weight: 302.43. | |
| Anecortave desacetate | Anecortave desacetate (AL-4940) is an angiogenesis inhibitor. Anecortave is indicated for the study of exudative (wet) age-related macular degeneration as well as retinal tumors [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AL-4940. CAS No. 10184-70-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-116098. | |
| β-carotene 15,15'-dioxygenase | Requires Fe2+. The enzyme cleaves β-carotene symmetrically, producing two molecules of all-trans-retinal. Both atoms of the oxygen molecule are incorporated into the products. The enzyme can also process β-cryptoxanthin, 8'-apo-β-carotenal, 4'-apo-β-carotenal, α-carotene and γ-carotene in decreasing order. The presence of at least one unsubstituted β-ionone ring in a substrate greater than C30 is mandatory. A prokaryotic enzyme has been reported from the uncultured marine bacterium 66A03, where it is involved in the proteorhodopsin system, which uses retinal as its chromophore. Group: Enzymes. Synonyms: blh (gene name); BCO1 (gene name); BCDO (gene name); carotene dioxygenase; carotene 15,15'-dioxygenase; BCMO1 (misleading); β-carotene 15,15'-monooxygenase (incorrect). Enzyme Commission Number: EC 1.13.11.63. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0583; β-carotene 15,15'-dioxygenase; EC 1.13.11.63; blh (gene name); BCO1 (gene name); BCDO (gene name); carotene dioxygenase; carotene 15,15'-dioxygenase; BCMO1 (misleading); β-carotene 15,15'-monooxygenase (incorrect). Cat No: EXWM-0583. | |
| BIX | BIX is a BiP (Hsp70-5) ER chaperone inducer that induces BiP expression in vitro and in vivo. BIX protects against ER-stress induced cell death in neuronal and retinal cell lines, and also protects against ischaemia-induced hippocampal cell death in vivo. Synonyms: 2-(3,4-Dihydroxyphenyl)-2-oxoethyl ester thiocyanic acid; Thiocyanic acid,2-(3,4-dihydroxyphenyl)-2-oxoethyl ester. Grades: ≥98% by HPLC. CAS No. 101714-41-4. Molecular formula: C9H7NO3S. Mole weight: 209.22. | |
| Butyryl-L-carnitine chloride | (R)-Butyryl Carnitine is a potential prodrug of Carnitine, via the carnitine transporter OCTN2 and the amino acid transporter ATB0,+. It is an inhibitor of intestinal transporters, which block carnitine uptake by the carnitine transporter with IC50s of 1.5 μM and glycine transport with IC50s of 4.6 μM in in human retinal pigment epithelial (HRPE) cells. Butyryl-L-carnitine is used for treating seizure disorders. Synonyms: L-Butyrylcarnitine; C4 Carnitine. Grades: ≥95%. CAS No. 162067-50-7. Molecular formula: C11H22NO4·Cl. Mole weight: 267.8. | |
| carotenoid isomerooxygenase | The enzyme, characterized from the moth Galleria mellonella and the fruit fly Drosophila melanogaster, is involved in the synthesis of retinal from dietary caroteoids in insects. The enzyme accepts different all-trans carotenoids, including β-carotene, α-carotene and lutein, and catalyses the symmetrical cleavage of the carotenoid and the simultaneous isomerization of only one of the products to a cis configuration. When the substrate is hydroxylated only in one side (as in cryptoxanthin), the enzyme preferentially isomerizes the hydroxylated part of the molecule. Group: Enzymes. Synonyms: ninaB (gene name). Enzyme Commission Number: EC 1.13.11.65. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0585; carotenoid isomerooxygenase; EC 1.13.11.65; ninaB (gene name). Cat No: EXWM-0585. | |
| Cell Proliferation Inducer, WS3 (N- (6- (4- (3- (4- ( (4- methyl piperazin-1-yl) methyl ) -3- (trifluoro methyl ) phenyl) ureido) phenoxy) pyrimidin-4-yl) cyclopropane carboxamide Hydrochloride) | A cell-permeable, diarylurea analog that can reversibly induce cell proliferation of primary retinal pigment epithelial (RPE) cells from rodents and from fetal and adult human donors (~25nM). Its action suggested to be mediated through Erb3 binding protein 1 (Ebp1). Non-proliferating RPE cells at passage 6 appear to respond well to WS3 treatment, whereas actively proliferating cells in passage 1 to 4 do not exhibit any increase in proliferation. These cells can differentiate into functional monolayer following WS3 withdrawal. However, WS3-expanded adult human RPE cells differentiate less effectively when compared to stem cell-derived RPE cells. The expanded RPE cells are shown to preserve vision when transplanted into rodent models of retinal degeneration. Also shown to induce proliferation of mouse R7T1 beta cells (EC50 = 74nM). Not reported to induce any genetic changes or tumorigenic events. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O? HCl. US Biological Life Sciences. | Worldwide |
| CKI 7 dihydrochloride | CKI 7 is a CK1 inhibitor, and also inhibits SGK, S6K1 and MSK1. In combination with SB 431542, CKI 7 was shown to induce retinal cell differentiation from human ESCs and iPSCs. Synonyms: CKI-7 dihydrochloride; N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulphonamide dihydrochloride. Grades: >98%. CAS No. 1177141-67-1. Molecular formula: C11H14Cl3N3O2S. Mole weight: 358.67. | |
| CL316243 Hydrate (Disodium 5- [ (2R) -2- [ [ (2R) -2- (3-Chlorophenyl) -2-hydroxyethyl] amino] propyl] -1, 3-benzodioxole-2, 2-dicarboxylate Hydrate) | A very potent agonist highly selective for beta-3 adrenoceptors (EC50 = 3nM). Widely used to assess the functional roles of beta-3 adrenoceptors in glucose homeostasis, thermogenesis, obesity, cardiac functions, retinal neurotoxicity, and tissue inflammation. Group: Biochemicals. Grades: Highly Purified. CAS No. 138908-40-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| E-Retinyl b-glucuronide | E-Retinyl b-glucuronide is a biomedical compound, used for studying retinal diseases. Derived from retinol, this compound is indispensable in preserving visual acuity and upholding retinal well-being. Synonyms: all-trans-Retinyl b-glucuronide. CAS No. 16639-19-3. Molecular formula: C26H38O7. Mole weight: 462.58. | |
| Faricimab | Faricimab, an overall good safety and tolerability profile, is a bispecific antibody targeting Angiopoietin-2 ( Ang-2 ) and vascular endothelial growth factor-A ( VEGF-A ). Faricimab prevents retinal vascular leakage, cell death and inflammation in retinal ischemia/reperfusion (I/R) injury and sCNV mouse models. Faricimab demonstrates statistically superior visual acuity gains versus Ranibizumab (HY-P9951). Faricimab can be used for retinal diseases, such as age-related macular degeneration (w-AMD), diabetic macular edema (DME) and macular edema following retinal vein occlusion (RVO) [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: RG7716. CAS No. 1607793-29-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99116. | |
| Ginsenoside Rh3 | Ginsenoside Rh3 is a bacterial metabolite of Ginsenoside Rg5. Ginsenoside Rh3 treatment in human retinal cells induces Nrf2 activation. Uses: Scientific research. Group: Natural products. CAS No. 105558-26-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N0606. | |
| Glycogen Phosphorylase Inhibitor | Glycogen phosphorylase inhibitor is a cell-permeable inhibitor of human liver glycogen phosphorylase with an IC50 value of 53 nM. It has been used in biological studies to study glycogen utilization in human liver HepG2 cells, retinal explants, and human T lymphocyte Kit 225 cells. Synonyms: GPI; 2-chloro-4, 5-difluoro-N- [ [ [2-methoxy-5- [ [ (methylamino) carbonyl] amino] phenyl] amino] carbonyl] -benzamide. Grades: ≥98%. CAS No. 648926-15-2. Molecular formula: C17H15ClF2N4O4. Mole weight: 412.8. | |
| GNE-495 | GNE-495 is a Selective MAP4K4 (Mitogen-activated protein kinase kinase kinase kinase 4) Inhibitor. IC50 value is 3.7 nM. GNE-495 shows excellent potency and good PK In vivo. GNE-495 was used to demonstrate in vivo efficacy in a retinal angiogenesis model recapitulating effects that are observed in the inducible Map4k4 knockout mice. Synonyms: GNE-495; GNE 495; GNE495. 8-amino-N-(1-(cyclopropanecarbonyl)azetidin-3-yl)-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxamide. Grades: 98%. CAS No. 1449277-10-4. Molecular formula: C22H20FN5O2. Mole weight: 405.43. | |
| GSK0660 | GSK0660 is a selective PPARδ antagonist. GSK0660 blocks the effect of TNFα on the expressions of cytokines involved in leukocyte recruitment, including CCL8, CCL17, and CXCL10, and it may block TNFα-induced retinal leukostasis. Synonyms: GSK0660; GSK-0660; GSK 0660. Grades: 96%. CAS No. 1014691-61-2. Molecular formula: C19H18N2O5S2. Mole weight: 418.48. | |
| HIOC | HIOC is a selective tropomyosin-related kinase receptor B (TrkB) receptor agonist with neuroprotective property. HIOC was shown to prevent retinas from light-induced retinal degeneration (LIRD) in vivo. HIOC is used in the treatment of early brain injury following subarachnoid hemorrhage (SAH). Synonyms: N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-2-oxo-3-piperidinecarboxamide. Grades: ≥98% by HPLC. CAS No. 314054-36-9. Molecular formula: C16H19N3O3. Mole weight: 301.34. | |
| Isopropyl unoprostone | Isopropyl unoprostone (Unoprostone isopropyl ester), an analogue of a prostaglandin metabolite, is a potent large conductance Ca 2+ -activated K + (BK) channels activator. Isopropyl unoprostone has antiglaucoma effects, lowering intraocular pressure (IOP) by increasing aqueous humour outflow. Isopropyl unoprostone can improve retinal sensitivity and the protection of central retinal sensitivity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Unoprostone isopropyl ester; UF-021. CAS No. 120373-24-2. Pack Sizes: 1 mg (23.55 mM * 100 μL in Methyl acetate). Product ID: HY-109545. | |
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