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| Product | Description | |
|---|---|---|
| Telomerase-IN-2 | Telomerase-IN-2 is a telomerase inhibitor, and inhibits telomerase activity by decreasing expression of dyskerin, with an IC 50 of 0.89?μM. Anti-cancer activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1610878-54-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126482. |  |
| Telomerase reverse transcriptase (461-469) | Human telomerase reverse transcriptase is a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component (TERC), comprises the most important unit of the telomerase complex. Synonyms: hTRT (461-469). |  |
| Telomerase reverse transcriptase (540-548) | Telomerase reverse transcriptase (540-548) is a peptide corresponding to residues 540-548 of Telomerase reverse transcriptase. Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It is active in progenitor and multiple cancer cells. Synonyms: HEST2 (540-548); Telomerase catalytic subunit (540-548); Telomerase-associated protein 2 (540-548). | |
| Telomerase reverse transcriptase (672-686) | Telomerase reverse transcriptase (672-686) is a peptide corresponding to residues 672-686 of Telomerase reverse transcriptase. Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It is active in progenitor and multiple cancer cells. Synonyms: HEST2 (672-686); Telomerase catalytic subunit (672-686); Telomerase-associated protein 2 (672-686). | |
| Telomerase Reverse Transcriptase (674-683) | Human telomerase reverse transcriptase is a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component (TERC), comprises the most important unit of the telomerase complex. Synonyms: hTRT (674-683). | |
| Telomerase reverse transcriptase (766-780) | Telomerase reverse transcriptase (766-780) is a peptide corresponding to residues 766-780 of Telomerase reverse transcriptase. Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It is active in progenitor and multiple cancer cells. Synonyms: HEST2 (766-780); Telomerase catalytic subunit (766-780); Telomerase-associated protein 2 (766-780). | |
| Telomerase reverse transcriptase (865-873) | Telomerase reverse transcriptase (865-873) is a peptide corresponding to residues 865-873 of Telomerase reverse transcriptase. Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It is active in progenitor and multiple cancer cells. Synonyms: HEST2 (865-873); Telomerase catalytic subunit (865-873); Telomerase-associated protein 2 (865-873). | |
| 1,3-Dichloro-9,9-dimethyl-7-(phosphonooxy)-2(9H)-acridinone | 1,3-Dichloro-9,9-dimethyl-7-(phosphonooxy)-2(9H)-acridinone has been used as a component of an optical fiber nanobiosensor to detect telomerase as general cancer biomarker at single cell level followed by in vitro sandwich ELISA. This compound is also used in nanoparticle-based optical biosensors for the direct detection of organophosphate chemical warfare agents and pesticides. Group: Biochemicals. Grades: Highly Purified. CAS No. 301521-89-1. Pack Sizes: 2.5mg, 10mg. Molecular Formula: C15H12Cl2NO5P, Molecular Weight: 388.14. US Biological Life Sciences. |  Worldwide |
| 17-AAG | Potent, less toxic analog of geldanamycin. Inhibits the essential ATPase activity of HSP90. Telomerase activity inhibitor. Apoptosis inducer and antitumor compound. Group: Biochemicals. Grades: Highly Purified. CAS No. 75747-14-7. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| 2-(3,4-Diaminophenyl)-7,8-dihydroxy-4H-chromen-4-one | 2-(3,4-Diaminophenyl)-7,8-dihydroxy-4H-chromen-4-one is a catecholic flavonoids Acting as a possible telomerase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 460744-16-5. Pack Sizes: 5mg, 50mg. Molecular Formula: C15H12N2O4, Molecular Weight: 284.27. US Biological Life Sciences. | Worldwide |
| 2-Bromoethylamine-[d4] HBr | Labelled 2-Bromoethylamine HBr. 2-Bromoethylamine HBr is used in the synthesis of analogs of 5,?10,?15,?20-tetrakis(1-methylpyridinium-4-yl)?porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. Grade: 98% atom D. CAS No. 918633-70-2. Molecular formula: C2H3D4Br2N. Mole weight: 208.92. | |
| 2-Bromoethylamine HBr | 2-Bromoethylamine HBr is used in the synthesis of analogs of 5,?10,?15,?20-tetrakis(1-methylpyridinium-4-yl)?porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone. Synonyms: 2-Bromoethylamine Hydrobromide; 1-Amino-2-bromoethane Hydrobromide; 2-Aminoethyl Bromide Hydrobromide; 2-Bromoethylammonium Bromide; β-Bromoethylamine Hydrobromide. Grade: > 95%. CAS No. 2576-47-8. Molecular formula: C2H7Br2N. Mole weight: 204.89. | |
| 2-Bromoethylamine hydrobromide | It is used in the synthesis of analogs of 5,?10,?15,?20-tetrakis(1-methylpyridinium-4-yl)?porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-aminoethyl bromide hydrobromide;2-aminoethyl bromide hydrogen bromide;2-bromo-ethylamine hydrogen brom. Product Category: Amines. Appearance: Crystals. CAS No. 2576-47-8. Molecular formula: C2H7Br2N. Mole weight: 204.89. Purity: purum, ≥97.0% (AT). Density: 1.581 g/cm³. ECNumber: 219-924-2. Product ID: ACM2576478. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 2-Bromoethylamine Hydrobromide | 2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,?10,?15,?20-?tetrakis(1-?methylpyridinium-?4-?yl)?porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 2576-47-8. Pack Sizes: 100g, 250g. Molecular Formula: C2H7Br2N. US Biological Life Sciences. | Worldwide |
| 2'-Deoxy-N7-methylguanosine | 2'-Deoxy-N7-methylguanosine is a molecule that plays a vital role in biomedical research. It is often used as a substrate in enzymatic assays to study DNA replication and repair processes. Additionally, it has been found to have potential applications in cancer therapies, as it can target and inhibit telomerase, an enzyme commonly upregulated in cancer cells. Synonyms: 2'-Deoxy-7,8-dihydro-7-methylguanosine. CAS No. 26718-69-4. Molecular formula: C11H17N5O4. Mole weight: 283.28. | |
| 360A iodide | 360A is a 2,6-pyridine-dicarboxamide derivative displaying strong affinity and selectivity for G-quadruplex structures and selective telomerase inhibition in vitro assays. It is a G-quadruplex ligand, which can influence the consequence of G-quadruplex formation and/or stabilization. Synonyms: 360A iodide; 360 A iodide; 360-A iodide. Grade: >98%. CAS No. 737763-37-0. Molecular formula: C27H23I2N5O2. Mole weight: 703.31. | |
| 6-Thio-2'-Deoxyguanosine | 6-Thio-2'-Deoxyguanosine is a nucleoside analogue that can be incorporated into de novo-synthesized telomeres by telomerase. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 6-thio-dG; ?-TGdR. CAS No. 789-61-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18762. | |
| 6-Thio-dG | 6-thio-dG is a nucleoside analog and telomerase substrate. Uses: Studies suggest that beta-tgdr is a latent form of tg. since resistance to antileukemic agent 6-thioguanine inevitably develops in animal tumors, this new agent beta-tgdr is of potential clinical use. Synonyms: 6-Thio-2'-Deoxyguanosine; 2-Amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-9H-purine-6(1H)-thione; 2-Amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-mercaptopurine; 2'-Deoxythioguanosine; 2'-Desoxy-6-thioguanosine; NSC 71261; TGdR; Thioguanine Deoxyriboside; β-Thioguanine Deoxyriboside. Grade: ≥97% by HPLC. CAS No. 789-61-7. Molecular formula: C10H13N5O3S. Mole weight: 283.31. | |
| 7-Propargylamino-7-deaza-dATP - ATTO-Rho14 | 7-Propargylamino-7-deaza-dATP, also referred to as ATTO-Rho14, is a fluorescent nucleotide analog that is frequently utilized in DNA sequencing and PCR applications. This molecule, however, has greater implications and applications in the scientific community beyond these areas. It is of particular interest in relation to the study of telomerase and telomeres, as well as the detection and quantification of specific DNA sequences. Given its chemical composition, it has the potential to provide unprecedented insights into the diagnosis and treatment of various diseases. Thus, the potency of this molecule in biomedicine research is immeasurable. Synonyms: 7-Deaza-7-propargylamino-2'-deoxyadenosine-5'-triphosphate, labeled with ATTO Rho14, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C55H61Cl4N8O15P3 (free acid). Mole weight: 1306.22 (free acid). | |
| 7-Propargylamino-7-deaza-ddGTP - Texas Red | 7-Propargylamino-7-deaza-ddGTP - Texas Red, a fluorescent nucleotide analog, is an ideal labeling tool in biomedical analysis to visualize the cellular localization or metabolic incorporation of DNA. With the potential to be incorporated into DNA by reverse transcriptase, this product facilitates studying DNA replication, DNA repair, and telomerase activity, opening doors to explore viral infections, cancer biology, and gene regulation. Its diverse range of applications makes it a valuable addition to any laboratory. Synonyms: 7-Deaza-7-propargylamino-2',3'-dideoxyguanosine-5'-triphosphate, labeled with Texas Red, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C51H59N8O19P3S2 (free acid). Mole weight: 1245.11 (free acid). | |
| Abacavir | Abacavir is an orally active and competitive nucleoside reverse transcriptase inhibitor. Abacavir can inhibits the replication of HIV. Abacavir shows anticancer activity in prostate cancer cell lines. Abacavir can trespass the blood-brain-barrier and suppresses telomerase activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 136470-78-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-17423. | |
| Abacavir sulfate | Abacavir sulfate (Abacavir Hemisulfate) is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir sulfate can inhibits the replication of HIV. Abacavir sulfate shows anticancer activity in prostate cancer cell lines. Abacavir sulfate can trespass the blood-brain-barrier and suppresses telomerase activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Abacavir Hemisulfate; ABC sulfate. CAS No. 188062-50-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-17423A. | |
| Alrefimotide | Alrefimotide is an immunological agent for active immunization. Synonyms: telomerase reverse transcriptase (human TERT, hTERT, EC:2.7.7.49) (660-689)-peptide; L-alanyl-L-leucyl-L-phenylalanyl-L-seryl-L-valyl-L-leucyl-L-asparaginyl-L-tyrosyl-L-α-glutamyl-L-arginyl-L-alanyl-L-arginyl-L-arginyl-L-prolylglycyl-L-leucyl-L-leucylglycyl-L-alanyl-L-seryl-L-valyl-L-leucylglycyl-L-leucyl-L-α-aspartyl-L-α-aspartyl-L-isoleucyl-L-histidyl-L-arginyl-L-alanine; Telomerase reverse transcriptase 660-689 peptide antigen. CAS No. 1331848-79-3. Molecular formula: C146H239N45O41. Mole weight: 3280.78. | |
| AzTTP | AzTTP is a metabolite of Zidovudine that shows an anti-HIV activity in vivo. AzTTP inhibits reverse transcriptase, telomerase (IC50 = 80 μM) and thymidine phosphorylation. Synonyms: 3'-Azido-ddTTP; 3'-Azido-2',3'-dideoxythymidine-5'-Triphosphate; AZT-TP; Zidovudine Triphosphate; Azidothymidine Triphosphate. Grade: ≥ 95% by HPLC. CAS No. 906479-25-2. Molecular formula: C10H16N5O13P3 (free acid). Mole weight: 507.18 (free acid). | |
| BCH001 | BCH001, a quinoline derivative, is a specific PAPD5 inhibitor. BCH001 restores telomerase activity and telomere length in dyskeratosis congenita (DC) induced pluripotent stem cells. BCH001 shows no inhibition of poly(A)-specific ribonuclease (PARN) or several other canonical and non-canonical polynucleotide polymerases. BCH001 is used to regulate aging[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 384859-58-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137817. | |
| BCH001 | BCH001 is a specific PAPD5 inhibitor. BCH001 restores telomerase activity and telomere length in DC patient induced pluripotent stem cells. Synonyms: 2-((3-(Ethoxycarbonyl)-6-(trifluoromethoxy)quinolin-4-yl)amino)benzoicacid. CAS No. 384859-58-9. Molecular formula: C20H15F3N2O5. Mole weight: 420.34. | |
| BIBR 1532 | BIBR 1532 is a potent, selective and non-competitive telomerase inhibitor with IC 50 of 100 nM in a cell-free assay. Uses: Scientific research. Group: Signaling pathways. CAS No. 321674-73-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17353. | |
| BIBR 1532 | BIBR 1532 is a potent, selective, non-competitive telomerase inhibitor with IC50 of 100 nM.BIBR1132 is highly selective for inhibition of telomerase, resulting in delayed growth arrest of tumor cells. Treatment of cancer cells with BIBR1532 leads to progressive telomere shortening, consecutive telomere dysfunction, and finally growth arrest after a lag period that is largely dependent on initial telomere length. Synonyms: BIBR1532; BIBR-1532; BIBR 1532. Grade: >98%. CAS No. 321674-73-1. Molecular formula: C21H17NO3. Mole weight: 331.36. | |
| Bisindolylmaleimide I | Cell permeable kinase inhibitor with improved selectivity for protein kinase C (PKC) (Ki = 10 nM). Competetive inhibitor for the ATP-binding site of PKC. Anti-inflammatory. Binds to P-glycoprotein. Telomerase activity inhibitor. Potent glycogen synthase kinase-3 (GSK-3) inhibitor. Necrosis inhibitor. Blocks hERG potassium channels. Group: Biochemicals. Alternative Names: GF-109203X, Gö 6850, BIM I. Grades: Highly Purified. CAS No. 133052-90-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C25H24N4O2. US Biological Life Sciences. | Worldwide |
| Bisindolylmaleimide I hydrochloride | Cell permeable kinase inhibitor with improved selectivity for protein kinase C (PKC) (Ki = 10 nM). Competitive inhibitor for the ATP-binding site of PKC. Anti-inflammatory. Binds to P-glycoprotein. Telomerase activity inhibitor. Potent glycogen synthase kinase-3 (GSK-3) inhibitor. Necrosis inhibitor. Blocks hERG potassium channels. Group: Biochemicals. Alternative Names: GF 109203X, Gö 6850, BIM I. Grades: Highly Purified. CAS No. 176504-36-2. Pack Sizes: 1mg, 5mg. Molecular Formula: C25H24N4O2. HCl. US Biological Life Sciences. | Worldwide |
| BMVC | BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor with an IC 50 of ~0.2 μM. BMVC inhibits Taq DNA polymerase with an IC 50 of ~2.5 μM. BMVC increases the melting temperature of G4 structure of telomere and accelerates telomere length shortening. Anticancer activities [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 627810-06-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135775. | |
| BMVC | BMVC is the first fluorescent probe designed to detect G-quadruplexes (G4s) in vivo. BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor. Grade: 98%. CAS No. 627810-06-4. Molecular formula: C28H25I2N3. Mole weight: 657.33. | |
| Braco-19 | Braco-19 is a potent telomerase/telomere inhibitor, preventing the capping and catalytic action of telomerase. Braco-19 acts as G-quadruplex (GQ) binding ligand, stabilizing G-quadruplexes formation at the 3V telomeric DNA overhang and produce rapid senescence or selective cell death. Braco-19 is also a HAdV virus replication inhibitor[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 351351-75-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15523. | |
| Braco-19 | Braco-19 is a potent telomerase/telomere inhibitor that prevents telomerase catalysis. Braco-19, as a G-quadruplex (GQ) binding ligand, stabilizes GQ formation at 3V telomeric DNA overhang and produces rapid senescence or selective cell death. It is also an HAdV virus replication inhibitor. Uses: Cytostatic agents. Synonyms: N-(9-{[4-(dimethylamino)phenyl]amino}-6-[3-(pyrrolidin-1-yl)propanamido]acridin-3-yl)-3-(pyrrolidin-1-yl)propanamide; N,N'-[9[[4-(Dimethylamino)phenyl]amino]-3,6-acridinediyl]bis-1-pyrrolidinepropanamide; 9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyrrolodinopropionamido)acridine. Grade: ≥95%. CAS No. 351351-75-2. Molecular formula: C35H43N7O2. Mole weight: 593.76. | |
| Braco-19 trihydrochloride | Braco-19 trihydrochloride is a potent telomerase/telomere inhibitor, preventing the capping and catalytic action of telomerase. Braco-19 acts as G-quadruplex (GQ) binding ligand, stabilizing G-quadruplexes formation at the 3V telomeric DNA overhang and produce rapid senescence or selective cell death. Braco-19 is also a HAdV virus replication inhibitor[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1177798-88-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15523A. | |
| BRACO 19 trihydrochloride | BRACO 19 trihydrochloride is a telomerase inhibitor (IC50 = 115 nM) that suppresses the expression of human telomerase reverse transcriptase (hTERT) and induces cellular senescence. BRACO 19 was shown to inhibit growth of uterine cancer cells in vitro and growth of uterine tumor xenografts in mice. Synonyms: N,N'-[9[[4-(Dimethylamino)phenyl]amino]-3,6-acridinediyl]bis-1-pyrrolidinepropanamide trihydrochloride. Grade: ≥95% by HPLC. CAS No. 1177798-88-7. Molecular formula: C35H43N7O2.3HCl. Mole weight: 703.14. | |
| Costunolide | Costunolide, a natural sesquiterpene compound with multiple biological activities, inhibits FPTase with IC50 of 20 μM, and also inhibits telomerase with IC50 of 65-90 μM. Uses: Anti-inflammatory and anti-oxidant. Synonyms: CCRIS 6754; NSC 106404; CCRIS6754; NSC106404; CCRIS-6754; NSC-106404. Grade: >98%. CAS No. 553-21-9. Molecular formula: C15H20O2. Mole weight: 232.32. | |
| Cycloastragenol | Cycloastragenol (Astramembrangenin), the active form of astragaloside IV, has anti-oxidant, anti-inflammatory, anti-aging, anti-apoptotic, and cardiovascular protective effects. Cycloastragenol is a potent telomerase activator and can lengthen telomeres. Cycloastragenol alleviates age-related bone loss and improves bone microstructure and biomechanical properties [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Astramembrangenin; Cyclosieversigenin. CAS No. 78574-94-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 20 mg. Product ID: HY-N1485. | |
| Cycloastragenol | Cycloastragenol, belongs to the triterpene saponins, is mainly obtained from the hydrolysis of Astragaloside IV. Cycloastradiol is the only telomerase activator found today. It delays the shortening of telomeres by increasing telomerase. Cycloastradiol is believed to have anti-aging effects. Cycloastragenol can be used in cosmetics material. Synonyms: 9,19-Cyclolanostane-3,6,16,25-tetrol, 20,24-epoxy-, (3β,6α,16β,20R,24S)-; (3β,6α,16β,20R,24S)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol; Astramembrangenin; Cyclosieversigenin; Cyclosiversigenin; Cyloastragenol; (2aR,3R,4S,5aS,5bS,7S,7aR,9S,11aR,12aS)-3-((2R,5S)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-2a,5a,8,8-tetramethyltetradecahydro-1H,12H-cyclopenta[a]cyclopropa[e]phenanthrene-4,7,9-triol. Grade: 98%. CAS No. 78574-94-4. Molecular formula: C30H50O5. Mole weight: 490.72. | |
| Diazaphilonic acid | Diazaphilonic acid is produced by the strain of Talaramuces flavus PF1195. It has no antibacterial activity, but inhibits the ability of DNA amplification and telomerase. Molecular formula: C42H32O18. Mole weight: 824.69. | |
| ELLIPTICINE | Ellipticine is a DNA intercalating agent and a DNA topoisomerase II inhibitor. Ellipticine is also a natural product, isolated in 1959 from the Australian evergreen tree of the Apocynaceae family. Ellipticine was found to be an extremely promising anticancer drug. The planar polycyclic structure was found to interact with DNA through intercalation, exhibiting a high DNA binding affinity (10(6) M(-1)). The presence of protonatable ring nitrogens distinguished ellipticine from other simple intercalators. Both monocationic and uncharged species were found to be present under physiological conditions. The positive charge stabilized the binding of ellipticine to nucleic acids, while the more lipophilic uncharged compound was shown to readily penetrate membrane barriers. The structural nature of these compounds offers a plausible basis for the implication of multiple modes of action, including DNA binding, interactions with membrane barriers, oxidative bioactivation and modification of enzyme function; most notably that of topoisomerase II and telomerase. (Curr Med Chem Anticancer Agents. 2004 Mar;4(2):149-72). Synonyms: BRN 0221300; CCG-36483; CCRIS 2003; DB-052047; elliptecine; ellipticine; Elliptisine; K00071; LP00531; LS-133282; NSC 71795; NSC71795; NSC-71795; TCMDC-125546; VZ29809. Grade: 0.98. CAS No. 519-23-3. Molecular formula: C17H14N2. Mole weight: 246.31. | |
| (-)-Epigallocatechin Gallate (EGCG) | (-)-Epigallocatechin Gallate is a tumor-inhibiting constituent of green tea. (-)-Epigallocatechin Gallate alters the cleavage of amyloid precursor protein, decreasing production of ß-amyloid and amyloid plaques in mice. This compound has neuroprotective properties; Inhibits telomerase and DNA methyltransferase; antioxidant. Group: Biochemicals. Alternative Names: Teavigo; epi-Gallocatechin 3-O-Gallate; epi-Gallocatechin Gallate; EGCG; Epigallocatechin-3-monogallate; L-Epigallocatechin Gallate; 3-O-Galloyl-(-)-epigallocatechin; (-)-cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7- triol 3-gallate; (-)-cis-3,3',4,5,5,7-Hexahydroxy-flavane-3-gallate. Grades: Highly Purified. CAS No. 989-51-5. Pack Sizes: 100mg, 250mg, 500mg, 1g. Molecular Formula: C??H??O??, Molecular Weight: 458.37. US Biological Life Sciences. | Worldwide |
| Epitalon | Epitalon is an anti-aging agent and a telomerase activator. Epitalon has an inhibitory effect of the on the development of spontaneous tumors in mice, has geroprotective actions and intranasal administration increases neuronal activity. Epitalon can be used for cancer, old age and Retinitis Pigmentosa [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Epithalon; Epithalamin. CAS No. 307297-39-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1149. | |
| Epitalon | Epitalon is a synthetic tetra-peptide used to regulate the cell cycle through up-regulation of telomerase activity showing anticancer and anti-tumor metastatic effect. Uses: Regulate the cell cycle through up-regulation of telomerase activity. Synonyms: H-Ala-Glu-Asp-Gly-OH; (S)-4-((S)-2-aminopropanamido)-5-(((S)-3-carboxy-1-((carboxymethyl)amino)-1-oxopropan-2-yl)amino)-5-oxopentanoic acid; BDM-E; Epitalon; L-Alanyl-L-α-glutamyl-L-α-aspartylglycine. Grade: ≥98%. CAS No. 307297-39-8. Molecular formula: C14H22N4O9. Mole weight: 390.35. | |
| Epitalon TFA | AEDG peptide can epigenetically regulate neuronal differentiation gene expression and protein synthesis in human stem cells. Epitalon (Ala-Glu-Asp-Gly) TFA is one of AEDG peptide. Epitalon TFA is an anti-aging agent and a telomerase activator. Synonyms: Epithalon TFA; Epithalamin TFA. Grade: 98%. Molecular formula: C16H23F3N4O11. Mole weight: 504.37. | |
| Ganoderic Acid B | Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Powder. CAS No. 81907-61-1. Molecular formula: C30H44O7. Mole weight: 516.7. Purity: 0.98. IUPACName: (2R,6R)-6-[(3S,5R,7S,10S,13R,14R,17R)-3,7-dihydroxy-4,4,10,13,14-pentamethyl-11,15-dioxo-2,3,5,6,7,12,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-4-oxoheptanoic acid. Canonical SMILES: CC(CC(=O)CC(C)C(=O)O)C1CC(=O)C2(C1(CC(=O)C3=C2C(CC4C3(CCC(C4(C)C)O)C)O)C)C. Product ID: ACM81907611. Alfa Chemistry ISO 9001:2015 Certified. | |
| hTRT (615-624) | Human telomerase reverse transcriptase is a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component (TERC), comprises the most important unit of the telomerase complex. Synonyms: Human telomerase reverse transcriptase (615-624). | |
| hTRT (988-997) | Human telomerase reverse transcriptase is a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component (TERC), comprises the most important unit of the telomerase complex. Synonyms: Human telomerase reverse transcriptase (988-997). | |
| Hypericin | Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase , reverse transcriptase , telomerase and CYP ( cytochrome P450 ). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 548-04-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-N0453. | |
| Hypericin | Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Anthroquinone. Product Category: Inhibitors. Appearance: Powder. CAS No. 548-04-9. Molecular formula: C30H16O8. Mole weight: 504.44. Purity: 0.98. Canonical SMILES: CC1=CC(=C2C3=C1C4=C5C(=C(C=C4C)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O. Product ID: ACM548049. Alfa Chemistry ISO 9001:2015 Certified. | |
| Hypericin (Standard) | Hypericin (Standard) is the analytical standard of Hypericin. This product is intended for research and analytical applications. Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase , reverse transcriptase , telomerase and CYP ( cytochrome P450 ). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 548-04-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0453R. | |
| MKT 077 | MKT-077 is used in the treatment of Alzheimers diseases and other tauopathies. Also, is a rhodacyanine derivative that selectively targets cancer cells and overcomes tamoxifen resistance. Binds mot-2; selectively cytotoxic in cancer cells.Biological Activity:Occupies mortalin-2 (mot-2), a member of the Hsp70 family, at its p53 binding site and enables p53 translocation to the nucleus. Selectively cytotoxic; causes growth arrest of cancer cells in culture. Also inhibits telomerase activity and cross-links F-actin. Group: Biochemicals. Alternative Names: 1-Ethyl-2- [ [3-ethyl-5- (3-methyl-2 (3H) -benzothiazolylidene) -4-oxo-2-thiazolidinylidene] methyl] -pyridinium Chloride; FJ 776. Grades: Highly Purified. CAS No. 147366-41-4. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C??H??N?OS??; Ci, Molecular Weight: 441.01. US Biological Life Sciences. | Worldwide |
| Mst-312 | MST-312 is a telomerase inhibitor. MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). MST-312 can be used for the research of cancer, such as multiple myeloma (MM). Uses: Designed for use in research and industrial production. Additional or Alternative Names: Telomerase Inhibitor IX, MST-312, CHEMBL2170856, N,N-bis(2,3-Dihydroxybenzoyl)-1,3-phenylenediamine, 368449-04-1, CTK1B6051, IN1063, ZINC03937611, AG-F-28784, Benzamide, N,N-1,3-phenylenebis[2,3-dihydroxy-, N,N inverted exclamation marka-1,3-Phenylenebis-[2,3-dihydroxy-benzamide]. Product Category: Inhibitors. Appearance: Solid. CAS No. 368449-04-1. Molecular formula: C20H18N2O6. Mole weight: 382.37. Purity: ≥95%. IUPACName: N-[3-[(2,3-dihydroxybenzoyl)amino]phenyl]-2,3-dihydroxybenzamide. Canonical SMILES: C1=CC(=CC(=C1)NC(=O)C2=C(C(=CC=C2)O)O)NC(=O)C3=C(C(=CC=C3)O)O. Product ID: ACM368449041. Alfa Chemistry ISO 9001:2015 Certified. Categories: Mt. 3:12. | |
| MST-312 | MST-312 is a telomerase inhibitor. MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). MST-312 can be used for the research of cancer, such as multiple myeloma (MM)[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Telomerase Inhibitor IX. CAS No. 368449-04-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120145. | |
| mTERT (572-580) | A peptide fragment of mTERT. Mouse telomerase reverse transcriptase (mTERT) is a gene that is expressed by cells that need to continually divide without the characteristic shortening of telomeres that accompanies DNA replication. Synonyms: hTERT R572Y peptide; Mouse telomerase reverse transcriptase (572-580). | |
| Native Avian myeloblastosis virus AMV-Reverse Transcriptase | A Reverse transcriptase (RT) is an enzyme used to geneRate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription. It is mainly associated with retroviruses. However, non-retroviruses also use RT (for example, the hepatitis B virus, a member of the Hepadnaviridae, which are dsDNA-RT viruses, while retroviruses are ssRNA viruses). RT inhibitors are widely used as antiretroviral drugs. RT activities are also associated with the replication of chromosome ends (telomerase) and some mobile genetic elements (retrotransposons). Applications: Amv reverse transcriptase synthesizes dna complementary (cdna) to rna templates. a dna primer complementary to the rna template and a divalent cation, either mg or mn, are required for initiation of transcription. this enzyme is commonly used to make cdnas from mrna for eventual cloning or for use as probes. Group: Enzymes. Synonyms: DNA nucleotidyltransferase (RNA-directed); reverse transcripta. Enzyme Commission Number: EC 2.7.7.49. CAS No. 9068-38-6. RT. Storage: -70°C. Source: Avian myeloblastosis virus. DNA nucleotidyltransferase (RNA-directed); reverse transcriptase; revertase; RNA-dependent deoxyribonucleate nucleotidyltransferase; RNA revertase; RNA-dependent DNA polymerase; RNA-instructed DNA polymerase; RT; EC 2.7.7.49; 9068-38-6. Cat No: NATE-0073. |  |
| RHPS4 | RHPS4 is a potent telomerase inhibitor (IC50 = 0.33 ?M). RHPS4 is a DNA damage inducer[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 390362-78-4. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-101089. | |
| Rubromycin Beta (Methyl-8,10'-dihydroxy-5,7-dimethoxy-4,9,9'-trioxo-4,4',9,9'-tetrahydro-3H,3'H-spiro[naphtho[2,3-b]furan-2,2'-pyrano[4,3-g]chromene]-7'-carboxylate) | Antibiotic. HIV-1 reverse transcriptase inhibitor. Human telomerase inhibitor. Cytostatic against different tumor cell lines. Group: Biochemicals. Grades: Highly Purified. CAS No. 27267-70-5. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Rubromycin Gamma | Antibiotic. HIV-1 reverse transcriptase and human telomerase inhibitor. Antibacterial. Cytostatically active against different tumor cell lines. Group: Biochemicals. Grades: Highly Purified. CAS No. 27267-71-6. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Telomerare Reverse Transcriptase (hTRT) (653-661) | Human telomerase reverse transcriptase is a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component (TERC), comprises the most important unit of the telomerase complex. Synonyms: hTRT (653-661). | |
| Telomestatin | Telomostatin, originally isolated from the bacteria Streptomyces anulatus, is a potent and specific telomerase inhibitor that acts only on human telomere sequences and does not affect DNA polymerases or reverse transcriptases. Telomostatin induces the formation of basket-type G-quadruplex (G4) structures from hybrid-type G-quadruplexes in the telomeric region. Synonyms: (R)-Telomestatin; GM 95; SOT 09; 3,7,11,15,19,23,27-Heptaoxa-31-thia-33,34,35,36,37,38,39,40-octaazanonacyclo[28.2.1.12,5.16,9.110,13.114,17.118,21.122,25.126,29]tetraconta-2(40),4,6(39),8,10(38),12,14(37),16,18(36),20,22(35),24,26(34),28,30(33)-pentadecaene, 4,8-dimethyl-, (1R)-. Grade: ≥95%. CAS No. 265114-54-3. Molecular formula: C26H14N8O7S. Mole weight: 582.50. | |
| TERT activator-1 | TERT activator-1 is a small molecule activator of telomerase reverse transcriptase (TERT). TERT activator-1 promotes TERT transcription through the MEK/ERK/AP-1 signaling cascade. TERT activator-1 promotes adult neurogenesis and enhances neuromuscular function. TERT activator-1 reduces cellular senescence and systemic inflammation in aged mice, and can be used in the study of aging[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 666699-46-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-402361. | |
| Thielavin A | The fungal metabolite thielavin A and its relatives are glucose-6-phosphatase inhibitors. The three benzoic acid units are essential for inhibition. Thielavin A was originally isolated as a inhibitor of prostaglandin biosynthesis. The closely related thielavin B is a telomerase and cell wall transglycosylation inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 71950-66-8. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| TMPyP4 tosylate | TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand. TMPyP4 tosylate inhibits the interaction between G-quadruplexes and IGF-1. TMPyP4 tosylate is a telomerase inhibitor and inhibits cancer cells proliferation. TMPyP4 tosylate is also a stabilizer of nucleic acid secondary structure and an acetylcholinesterase inhibitor. Besides, TMPyP4 tosylate has antiviral activity against SARS-CoV-2[1][2][3][6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TMP 1363. CAS No. 36951-72-1. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108477. | |
| TMPyP4 Tosylate | TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand. TMPyP4 tosylate inhibits the interaction between G-quadruplexes and IGF-1. TMPyP4 tosylate is a telomerase inhibitor and inhibits cancer cells proliferation. TMPyP4 tosylate is also a stabilizer of nucleic acid secondary structure and an acetylcholinesterase inhibitor. Besides, TMPyP4 tosylate has antiviral activity against SARS-CoV-2. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Meso-Tetrakis(N-Methyl-4-Pyridyl)Porphine Tetrakis(P-Toluenesulfonate). Product Category: Inhibitors. Appearance: Soild. CAS No. 36951-72-1. Molecular formula: C72H74N8O12S4. Mole weight: 1371.66. Purity: 0.98. Product ID: ACM36951721-4. Alfa Chemistry ISO 9001:2015 Certified. | |
| Trichostatin A (TSA, A300, R-(E,E)-7-(4-(dimethylamino)phenyl)-N-hydroxy- 4,6-dimethyl-7-oxo-2,4-heptadienamide) | Antibiotic. Antifungal. Antiprotozoal. Potent and reversible, cell permeable inhibitor of histone deacetylase (HDAC). Immunosuppressive. Anticancer compound. Antifibrogenic. Apoptosis inducer. Induces cell growth arrest at both G1 and G2/M phases. Enhances the efficacy of anticancer agents that target DNA. Inactivates mitotic spindle checkpoint. Smooth muscle cell proliferation inhibitor. Telomerase inhibitor. Downregulates DNA methyltransferase DNMT1 and affects DNA methylation. Anti-inflammatory. Inhibits osteoclastogenesis and bone resorption. Group: Biochemicals. Alternative Names: TSA, A300, R-(E,E)-7-(4-(dimethylamino)phenyl)-N-hydroxy- 4,6-dimethyl-7-oxo-2,4-heptadienamide. Grades: Highly Purified. CAS No. 58880-19-6. Pack Sizes: 1mg, 5mg. Molecular Formula: C17H22N2O3, Molecular Weight: 302.4. US Biological Life Sciences. | Worldwide |
| Wogonin | Anti-inflammatory. Increases nitroc oxide (NO) production. Inhibits PGE2, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOS II). Antioxidant. Anti-viral. Shows anti-hepatitis B virus activity. MCP-1 inhibitor. Shows anxiolytic effect through modulation of the GABA(A) receptor complex. Antifungal. Neuroprotective. Anticancer compound. Apoptosis and cell cycle arrest inducer. Sensitizes TNFalpha- and TRAIL-induced apoptosis. Antiangiogenic. NF-kappaB inhibitor. Telomerase activity inhibitor. CDK9 inhibitor. PI3K-AKT pathway modulator. Autophagy inducer. Group: Biochemicals. Alternative Names: WOG, 5,7-Dihydroxy-8-methoxyflavone, BRN 0287152. Grades: Highly Purified. CAS No. 632-85-9. Pack Sizes: 5mg, 25mg. Molecular Formula: C16H12O5. US Biological Life Sciences. | Worldwide |
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