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| Product | Description | |
|---|---|---|
| 3`-Deoxy-5`-thymidylic Acid | 3`-Deoxy-5`-thymidylic Acid has been shown to complex with human thymidylate kinase via hydrogen bonding between Arg97 residues and phosphate groups. This interaction leads to the closed P-loop conformation in human thymidylate kinase, which promotes phosphorylation of nucleotides and has the potential as a model for novel compounds as a result of structure-based design studies. Group: Biochemicals. Grades: Highly Purified. CAS No. 3715-64-8. Pack Sizes: 10mg, 25mg. Molecular Formula: C10H15N2O7P, Molecular Weight: 306.211. US Biological Life Sciences. |  Worldwide |
| 5'-?O-?[Bis(4-?methoxyphenyl)?phenylmethyl]?-?3'-?Thymidylic Acid Bis(2-?cyanoethyl) Ester | 5'-O-[Bis(4-methoxyphenyl)?phenylmethyl]?-3'-Thymidylic Acid Bis(2-cyanoethyl) Ester is an intermediate in synthesizing Thymidine 5'-Triphosphate, 3'-Phosphate Triethylamine Salt, a derivative of Thymidine 5'-Triphosphate which is used for the biosynthesis of deoxyribonucleic acids by DNA polymerases and reverse transcriptases. Synonyms: Bis(2-cyanoethyl) ((2R,3S,5R)-2-(Hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl) Phosphate. CAS No. 76759-76-7. Molecular formula: C16H21N4O8P. Mole weight: 428.33. |  |
| 5'-Thymidylic acid, disodium salt | 5'-Thymidylic acid, disodium salt is a paramount biomedical compound, playing the role of a nucleotide analog. It exerts its inhibitory prowess on viral DNA replication, thereby impeding the rampant multiplication of the virus. Synonyms: Thymidine-5'-monophosphate disodium salt; sodium ((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl phosphate. Grades: ≥97% by HPLC. CAS No. 33430-62-5. Molecular formula: C10H13N2Na2O8P. Mole weight: 366.17. | |
| POLYDEOXYADENYLIC-THYMIDYLIC ACID SODIUM SALT | POLYDEOXYADENYLIC-THYMIDYLIC ACID SODIUM SALT. Group: Oligonucleotide polymers and copolymers. CAS No. 86828-69-5. |  |
| 2'-Deoxy-5-trifluoromethyluridine-5'-monophosphate | 2'-Deoxy-5-trifluoromethyluridine-5'-monophosphate is a vital compound in the biomedical industry. It is used in the development of antiviral drugs, particularly those aimed at treating RNA-based viruses such as HIV and hepatitis C. Synonyms: α,?α,?α-Trifluoro-5'-thymidylic acid; Trifluridine-5-phosphate; 5-Trifluoromethyl-2'-deoxyuridylic acid. CAS No. 345-02-8. Molecular formula: C10H12F3N2O8P. Mole weight: 376.18. | |
| 3'-Deoxy-3'-fluorothymidine-5'-monophosphate-d3 Disodium Salt | A thymidine-5'-O-monophosphate analogue, for Mycobacterium tuberculosis thymidylate kinase inhibition. Synonyms: 3'-Deoxy-3'-fluoro-5'-thymidylic Acid-d3 Disodium; 2',3'-Dideoxy-3'-fluoro-5-methyluridine-d3 5'-(Dihydrogen Phosphate) Disodium; 3'-Deoxy-3'-fluoro-thymidine-d3 Monophosphate Disodium; 3'-Fluoro-3'-deoxythymidine-d3 Monophosphate Disodium. Molecular formula: C10H9D33FN2Na2O7P. Mole weight: 371.18. | |
| 3'-Deoxy-3'-fluorothymidine-5'-monophosphate Disodium Salt | A thymidine-5'-O-monophosphate analogue as inhibitors of Mycobacterium tuberculosis thymidylate kinase. Synonyms: 3'-Deoxy-3'-fluoro-5'-thymidylic Acid Disodium; 2',3'-Dideoxy-3'-fluoro-5-methyluridine 5'-(Dihydrogen Phosphate) Disodium; 3'-Deoxy-3'-fluorothymidine Monophosphate Disodium; 3'-Fluoro-3'-deoxythymidine Monophosphate Disodium. Grades: 95%. CAS No. 1316845-74-5. Molecular formula: C10H12FN2Na2O7P. Mole weight: 368.16. | |
| dTMP kinase | This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:dTMP phosphotransferase. Other names in common use include thymidine monophosphate kinase, thymidylate kinase, thymidylate monophosphate kinase, thymidylic acid kinase, thymidylic kinase, deoxythymidine 5'-monophosphate kinase, TMPK, and thymidine 5'-monophosphate kinase. This enzyme participates in pyrimidine metabolism. Group: Enzymes. Synonyms: thymidine monophosphate kinase; thymidylate kinase; thymidylate monophosphate kinase; thymidylic acid kinase; thymidylic kinase; deoxythymidine 5'-monophosphate kinase; TMPK; thymidine 5'-monophosphate kinase. Enzyme Commission Number: EC 2.7.4.9. CAS No. 9014-43-1. TMPK. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3219; dTMP kinase; EC 2.7.4.9; 9014-43-1; thymidine monophosphate kinase; thymidylate kinase; thymidylate monophosphate kinase; thymidylic acid kinase; thymidylic kinase; deoxythymidine 5'-monophosphate kinase; TMPK; thymidine 5'-monophosphate kinase. Cat No: EXWM-3219. |  |
| Thymidine 3',5'-Diphosphate Disodium Salt | As a metabolite of Thymidine, Thymidine-3',5'-diphosphate (pTp) can be used as a model compound for studies of reactions leading to strand breaks in DNA. Synonyms: 3'-Thymidylic Acid 5'-(Dihydrogen Phosphate) Disodium Salt; 2'-Deoxythymidine 3',5'-Diphosphate Disodium; 3',5'-Bisphospho-2'-deoxythymidine Disodium; 3',5'-TDP Disodium; Deoxythymidine 3',5'-Diphosphate Disodium; PTP Disodium; Thymidine 3',5'-Bisphosphate Disodium. Grades: 95%. CAS No. 386229-77-2. Molecular formula: C10H14N2Na2O11P2. Mole weight: 446.15. | |
| Thymidine-3',5'-di(p-nitrophenyl Phosphate) Disodium Salt | It is an artificial chromophoric substrate, could be used as a synthetic substrate for bovine pancreatic deoxyribonuclease. Uses: An artificial chromophoric substrate. Synonyms: 3'-Thymidylic Acid Mono(4-nitrophenyl) Ester 5'-(4-Nitrophenyl Hydrogen Phosphate) Disodium Salt. CAS No. 24418-12-0. Molecular formula: C22H22N4Na2O15P2. Mole weight: 688.34. | |
| Thymidine-5'-monophosphate | Thymidine-5'-monophosphate, a nucleotide intermediate, serves as a research tool for gaining insights into intricate cellular processes and pathways engaged in DNA synthesis and repair. Studies utilizing Thymidine-5'-monophosphate extend to chemotherapy and antiviral drug development for possible therapeutic intervention. Its diverse extracellular functions can aid disease control. Synonyms: 5'-Thymidylic acid; dTMP; Thymidylic acid; Thymidine monophosphate; 5-Methyl-dUMP; Thymidine-5'-monophosphoric acid; Deoxy TMP; Thymidine 5'-(dihydrogen phosphate); NSC 46713; 2'-deoxy-5-methyluridine 5'-(dihydrogen phosphate). Grades: ≥98% by HPLC. CAS No. 365-07-1. Molecular formula: C10H15N2O8P. Mole weight: 322.21. | |
| Thymidine 5'-Monophosphate Disodium Salt Hydrate | A nucleoside monophosphate derived from phosphorylation of Thymidine, Which is converted to Thymidine diphosphate by Thymidylate kinase (TMPK), and it's a nucleoside monophosphate kinase. It's also a constituent of Deoxyribonucleic Acid. Synonyms: 5'-Thymidylic Acid Disodium Salt Hydrate; Disodium 5'-dTMP Hydrate; Disodium TMP Hydrate. Grades: 97%. Molecular formula: C10H13N2Na2O8P xH2O. Mole weight: 366.17. | |
| thymidylate 5'-phosphatase | Acts on 5-methyl-dCMP and on TMP, but more slowly than on dTMP. Group: Enzymes. Synonyms: thymidylate 5'-nucleotidase; deoxythymidylate 5'-nucleotidase; thymidylate nucleotidase; deoxythymidylic 5'-nucleotidase; deoxythymidylate phosphohydrolase; dTMPase. Enzyme Commission Number: EC 3.1.3.35. CAS No. 9026-80-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3638; thymidylate 5'-phosphatase; EC 3.1.3.35; 9026-80-6; thymidylate 5'-nucleotidase; deoxythymidylate 5'-nucleotidase; thymidylate nucleotidase; deoxythymidylic 5'-nucleotidase; deoxythymidylate phosphohydrolase; dTMPase. Cat No: EXWM-3638. | |
| 1-(2'-deoxy-2'-fluoro-3',5'-di-O-benzoyl-b-L-arabinofuranosyl)-uracil | 1-(2'-deoxy-2'-fluoro-3',5'-di-O-benzoyl-b-L-arabinofuranosyl)-uracil is a nucleoside analogue useful in cancer treatment research. This nucleoside analogue selectively interacts with a thymidylate synthase, inhibiting DNA synthesis thereby disrupting tumor cell growth. Synonyms: 1-(3,5-Di-O-benzoyl-2-deoxy-2-fluoro-beta-L-arabinofuranosyl)-2,4(1H,3H)-pyrimidinedione; 2,4(1H,3H)-Pyrimidinedione, 1-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-L-arabinofuranosyl)-; 3,5-di-O-benzoyl-1,2-dideoxy-2-fluoro-1-uracil-1-yl-beta-L-arabino-pentofuranose. CAS No. 1312300-53-0. Molecular formula: C23H19FN2O7. Mole weight: 454.40. | |
| 1-(2-Deoxy-b-D-threo-pentofuranosyl)-5-fluorouracil | 1-(2-Deoxy-b-D-threo-pentofuranosyl)-5-fluorouracil, an effective antineoplastic agent employed in the management of diverse malignancies such as colorectal, breast, and pancreatic cancer, showcases its mechanistic action by suppressing the vital enzyme, thymidylate synthase, thereby impeding DNA synthesis. Undoubtedly, this compound's profound pharmacological features render it an indispensable asset within the biomedicine realm, proficiently combating a myriad of malignant conditions. Synonyms: 5-Fluoro-1-[(2R,4R,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione. CAS No. 955-24-8. Molecular formula: C9H11FN2O5. Mole weight: 246.19. | |
| 2'-Deoxyuridine | 2-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimers disease (AD) [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 951-78-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-D0186. |  |
| 2'-Deoxyuridine 5'-monophosphate disodium | 2'-Deoxyuridine 5'-monophosphate (dUMP) disodium is a deoxynucleotide that is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS). dTMP is a nucleotide required for DNA synthesis [1]. Uses: Scientific research. Group: Natural products. Alternative Names: dUMP disodium. CAS No. 42155-08-8. Pack Sizes: 10 mM * 1 mL; 250 mg. Product ID: HY-W011142. | |
| 3-Deoxy-3-fluorothymidine-5-monophosphate-d3 Disodium Salt | A thymidine-5'-O-monophosphate analogue as inhibitors of Mycobacterium tuberculosis thymidylate kinase. Group: Biochemicals. Alternative Names: 3'-Deoxy-3'-fluoro-. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 3-Deoxy-3-fluorothymidine-5-monophosphate Disodium Salt | A thymidine-5'-O-monophosphate analogue as inhibitors of Mycobacterium tuberculosis thymidylate kinase. Group: Biochemicals. Alternative Names: 3'-Deoxy-3'-fluoro-. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 4-[2-(2-Amino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic Acid Methyl Ester | 4-[2-(2-Amino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid methyl ester is one of pemetrexed metabolites. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: Benzoic acid, 4-[2-(2-amino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]-, methyl ester; Pemetrexed Impurity 63; Methyl 4-[2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoate; Methyl 4-(2-(2-imino-4,6-dioxo-2,3,4,5,6,7-hexahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoate. Grades: ≥95%. CAS No. 1320346-43-7. Molecular formula: C16H16N4O4. Mole weight: 328.32. | |
| 5-(3-Amino-1-propen-1-yl)-2'-deoxyuridine | 5-(3-Amino-1-propen-1-yl)-2'-deoxyuridine, a potent chemotherapeutic agent against multiple types of cancer, works by inducing apoptosis and inhibiting DNA synthesis in malignant cells. Its active ingredient thwarts thymidylate synthase, blocking thymidine production and ultimately halting replication, stopping cancer in its tracks. This widely-used nucleoside treatment targets advanced cases of colon, ovarian, and breast cancer with remarkable success. Synonyms: 5-(3-Amino-1-propenyl)-2'-deoxyuridine; 5-[(E)-3-Amino-1-propenyl]-2'-deoxyuridine; Uridine, 5-(3-amino-1-propenyl)-2'-deoxy-; 5-[(1E)-3-Amino-1-propen-1-yl]-2'-deoxyuridine. Grades: ≥97% by HPLC. CAS No. 143908-73-0. Molecular formula: C12H17N3O5. Mole weight: 283.28. | |
| 5-Bromo-dUMP | 5-Bromo-dUMP is a highly active inhibitor of thymidylate synthase, serving as a pivotal component in hindering the catalytic ability of this vital enzyme involved in the research and development of DNA. Its efficacious employment as an antitumor compound against diverse malignancies proficiently impedes the generation of DNA, thus efficaciously curbing the proliferation of malignant cells inherent to cancerous growths. Synonyms: (5Br-dUMP); 5-Bromo-2'-deoxyuridine-5'-monophosphate, Sodium salt. Grades: ≥ 95% by HPLC. CAS No. 6666-38-2. Molecular formula: C9H12N2O8PBr (free acid). Mole weight: 387.08 (free acid). | |
| 5'-Deoxy-5'-fluorothymidine | 5'-Deoxy-5'-fluorothymidine, a compound of utmost significance in the biomedical field, manifests its indispensability in countering a diverse range of malignant neoplasms. Its profound therapeutic efficacy arises from its ability to impede the crucial enzymatic function of thymidylate synthase, pivotal for the replication and mending of DNA. Commencing with colorectal malignancies, this extraordinary product finds extensive utilization in chemotherapy protocols tailored for breast and pancreatic cancers as well. Synonyms: 2',5'-Dideoxy-5'-fluorothymidine. CAS No. 17199-43-8. Molecular formula: C10H13FN2O4. Mole weight: 244.22. | |
| 5-Fluoro-2'-deoxycytidine | 5-Fluoro-2'-deoxycytidine (FdCyd), a fluoropyrimidine nucleoside analogue, is a DNA methyltransferase ( DNMT) inhibitor. 5-Fluoro-2'-deoxycytidine is a tumor-selective proagent of thymidylate synthase inhibitor 5-fluoro-2-dUMP. 5-Fluoro-2'-deoxycytidine can induce cell cycle arrest in tumor cells through the DNA damage response, and it has anti-tumor activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FdCyd; NSC-48006. CAS No. 10356-76-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116217. | |
| 5-Fluorouracil | 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer [1] [2]. 5-Fluorouracil also inhibits HIV [3]. Uses: Scientific research. Group: Natural products. Alternative Names: 5-FU. CAS No. 51-21-8. Pack Sizes: 10 mM * 1 mL; 50 mg; 200 mg; 1 g; 5 g. Product ID: HY-90006. | |
| 5-Fluorouracil | Fluorouracil (5-Fluoracil, 5-FU) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS). Synonyms: 5-FU; Fluorouracil; Adrucil. Grades: >98%. CAS No. 51-21-8. Molecular formula: C4H3FN2O2. Mole weight: 130.08. | |
| 5-Fluorouracil-13C,15N2 | 5-Fluorouracil- 13 C, 15 N 2 is the 13 C and 15 N labeled 5-Fluorouracil[1]. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[2][3]. 5-Fluorouracil also inhibits HIV[4]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: 5-FU- 13 C, 15 N2. CAS No. 1189423-58-2. Pack Sizes: 1 mg. Product ID: HY-90006S1. | |
| 5-Fluorouracil-15n2 | 5-Fluorouracil-15N2 is the 15N-labeled 5-Fluorouracil. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer. 5-Fluorouracil also inhibits HIV. Group: Inhibitors. CAS No. 68941-95-7. Molecular formula: C4H3FN2O2. Mole weight: 132.1. Appearance: Solid. Purity: 98 atom % 15N. Canonical SMILES: O=C1C(F)=C[15NH]C([15NH]1)=O. Catalog: ACM68941957. |  |
| 5-Fluorouracil (Standard) | 5-Fluorouracil (Standard) is the analytical standard of 5-Fluorouracil. This product is intended for research and analytical applications. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer [1] [2]. 5-Fluorouracil also inhibits HIV [3]. Uses: Scientific research. Group: Natural products. CAS No. 51-21-8. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-90006R. | |
| 5-Fluoro-UTP | 5-Fluoro-UTP is an DNA/RNA synthesis inhibitor that terminate synthesis of nucleotide through inhibiting thymidylate synthase. It is used as an anticancer drug. Uses: 5-fluoro-utp is an dna/rna synthesis inhibitor. Synonyms: (5F-UTP); 5-Fluoro-uridine-5'-triphosphate, Sodium salt. Grades: ≥ 95% by HPLC. CAS No. 3828-96-4. Molecular formula: C9H14N2O15P3F (free acid). Mole weight: 502.13 (free acid). | |
| 5'-Tosyl Thymidine | A nucleoside analogue as inhibitors of thymidylate kinases. Synonyms: 5'-(4-Methylbenzenesulfonate)thymidine; 5'-O-(p-Toluenesulfonyl)thymidine; 5'-O-Tosylthymidine; NSC 69443. Grades: 98%. CAS No. 7253-19-2. Molecular formula: C17H20N2O7S. Mole weight: 396.41. | |
| 5-Trifluorothymidine | Trifluorothymidine is an inhibitor of TS (thymidylate synthase). It is also a substrate used to study the specificity and kinetics of thymidine kinases. Acts as an anti-herpesvirus drug by blocking viral DNA replication. Decreases CRISPR-mediated HDR (homology-directed repair) efficiency. Group: Biochemicals. Alternative Names: Trifluridine; Trifluorothymine Deoxyriboside; α, α, α-Trifluorothymidine; 2-Deoxy-5- (trifluoromethyl) uridine; 5-(Trifluoromethyl)-2-deoxyuridine; Viroptic. Grades: Highly Purified. CAS No. 70-00-8. Pack Sizes: 100mg, 250mg, 1g. Molecular Formula: C??H??F?N?O?, Molecular Weight: 296.2. US Biological Life Sciences. | Worldwide |
| 6-Aza-2-thiothymine | 6-Aza-2-thiothymine, a nucleoside analog widely utilized in cancer research, is profoundly effective in inhibiting thymidylate synthase; hence, it's active against several cancer cell lines. Furthermore, the compound's promising potential as a radiosensitizer renders it an excellent option for the management of solid tumors. This ground-breaking analog with unparalleled efficacy and versatility is a definitive focal point of modern-day cancer research. Synonyms: 2-Thio-6-azathymine; 6-Azathiothymine; 6-Methyl-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one; 3-mercapto-6-methyl-1,2,4-triazin-5(4H)-one; 6-Methyl-3-thioxo-3,4-dihydro-2H-[1,2,4]triazin-5-one; 1,2,4-Triazin-5(2H)-one, 3,4-dihydro-6-methyl-3-thioxo-; NSC 1609; NSC 38618; 3-Mercapto-6-methyl-as-triazin-5-ol; NSC 102906; 3,4-Dihydro-6-methyl-3-thioxo-1,2,4-triazin-5(2H)-one; 6-Methyl-3-thio-as-triazine-3,5(2H,4H)-dione. CAS No. 615-76-9. Molecular formula: C4H5N3OS. Mole weight: 143.17. | |
| (6S)-Tetrahydrofolic acid | (6S)-Tetrahydrofolic acid is 1000-fold more active than the (6R) form at promoting the binding of fluorodeoxyuridylate to thymidylate synthase and 600-fold more active as a growth factor of P. cerevisiae. (6S)-Tetrahydrofolic acid also has a low affinity and high dissociation rate for folate-binding protein [1]. Uses: Scientific research. Group: Natural products. Alternative Names: (6S)-5,6,7,8-Tetrahydrofolic acid. CAS No. 71963-69-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-14520A. | |
| ANX-510 | ANX-510 is a folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the fluorouracil metabolite 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (FdUMP) to its target enzyme, thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituent of DNA, and tumor cell death. Synonyms: 5,10-Methylenetetrahydrofolic acid; 5,10-Methylene-tetrahydrofolate; Tetrahydromethylenefolate; N-{4-[3-amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]benzoyl}-L-glutamic acid. CAS No. 3432-99-3. Molecular formula: C20H23N7O6. Mole weight: 457.44. | |
| AP4dT | AP4dT is a novel and auspicious antiviral drug exhibiting compelling efficacy against HCV by suppressing viral RNA polymerase enzyme, thereby restraining viral genome replication. Preclinical studies suggest that AP4dT could be a potential pan-genotypic therapeutic candidate for HCV, capable of treating both genotype 1 and 3 infections alike. Synonyms: P1-(5'-Adenosyl) P4-[5'-(2'-deoxy-thymidyl)] tetraphosphate, Triethylammonium salt. Grades: ≥ 95% by HPLC. CAS No. 13457-68-6. Molecular formula: C20H29N7O20P4 (free acid). Mole weight: 811.38 (free acid). | |
| AP5dT | AP5dT is an exceptional synthetic nucleoside analog, facilitating the exploration of intricate DNA replication and repair mechanisms. aP5dT can amplify the comprehension of virally-inflicted ailments (e.g., HIV, herpes) as well as diverse DNA-centric maladies. Synonyms: P1-(5'-Adenosyl) P5-[5'-(2'-deoxy-thymidyl)] pentaphosphate, Triethylammonium salt. Grades: ≥ 95% by HPLC. CAS No. 103137-88-8. Molecular formula: C20H30N7O23P5 (free acid). Mole weight: 891.36 (free acid). | |
| BGC-638 | BGC-638, an analogue of BGC-945, is a thymidylate synthase inhibitor specifically transported into α-folate receptor (α-FR)-overexpressing tumors. Synonyms: BGC 638; BGC638; CB300638; CB-300638; D-Glutamic acid, N-(4-(2-propyn-1-yl((6S)-4,6,7,8-tetrahydro-2-methyl-4-oxo-3H-cyclopenta(g)quinazolin-6-yl)amino)benzoyl)-L-gamma-glutamyl-. CAS No. 416852-27-2. Molecular formula: C32H33N5O9. Mole weight: 631.64. | |
| BGC-945 | BGC 945 is a cyclopenta[g]quinazoline-based, thymidylate synthase inhibitor specifically transported into α-folate receptor (α-FR)-overexpressing tumors. BGC 945 has low affinity for the widely expressed reduced-folate carrier (RFC). BGC 945 selectively inhibits thymidylate synthase in α-FR-overexpressing tumors and should cause minimal toxicity to humans at therapeutic doses. Synonyms: Idetrexed; ONX-0801; N-[4-[2-Propynyl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-1H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-L-γ-glutamyl-D-glutamic acid; N-[4-[2-Propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-L-γ-glutamyl-D-glutamic acid; (R) -2- ( (S) -4-carboxy-4- (4- ( ( (S) -2- (hydroxymethyl) -4-oxo-4, 6, 7, 8-tetrahydro-3H-cyclopenta[g]quinazolin-6-yl) (prop-2-yn-1-yl) amino) benzamido) butanamido) pentanedioic acid. Grades: ≥95%. CAS No. 501332-69-0. Molecular formula: C32H33N5O10. Mole weight: 647.63. | |
| CB30865 | CB30865 is a highly potent cytotoxic agent. The compound inhibits isolated mammalian thymidylate synthase (TS), but this inhibition is insufficient to account for its cellular toxicity. Thymidylate synthase (TS) is a critical enzyme in the de novo synthesis of thymidylate (dTTP) and has long been recognized as a target for chemotherapeutic intervention. Synonyms: CB-30865; CB 30865; CB30865; ZM 242421; ZM242421; ZM-242421. Grades: >98%. CAS No. 206275-15-2. Molecular formula: C26H22BrN5O2. Mole weight: 516.39. | |
| CB30900 | CB30900 has been found to be a thymidylate synthase inhibitor that could have some extent of activity in models with low or defective folylpolyglutamate synthetase. Synonyms: CB 30900; CB30900; CB-30900; N-(N-(4-(N-((3,4-Dihydro-2,7-dimethyl-4-oxo-6-quinazolinyl)methyl)-N-prop-2-ynylamino)-2-fluorobenzoyl)-L-gamma-glutamyl)-D-glutamic acid. Grades: 98%. CAS No. 145788-82-5. Molecular formula: C31H32FN5O9. Mole weight: 637.61. | |
| CB 3731 | CB 3731 can be used in fluorine-19 nuclear magnetic resonance studies of binary and ternary complexes of thymidylate synthase. Synonyms: CB 3731; CB-3731; CB3731. N-(4-((N-(2-Amino-4-hydroxy-6-quinazolinyl)methyl)-N-(fluoroethyl)amino)benzoyl)glutamic acid. Grades: 98%. CAS No. 80015-07-2. Molecular formula: C23H24FN5O6. Mole weight: 458.47. | |
| dihydrofolate reductase | The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. Group: Enzymes. Synonyms: tetrahydrofolate dehydrogenase; DHFR; pteridine reductase:dihydrofolate reductase; dihydrofolate reductase:thymidylate synthase; thymidylate synthetase-dihydrofolate reductase; folic acid reductase; folic reductase; dihydrofolic acid reductase; dihydrofolic reductase; 7,8-dihydrofolate reductase; NADPH-dihydrofolate reductase. Enzyme Commission Number: EC 1.5.1.3. CAS No. 9002-3-3. Dihydrofolate Reductase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1511; dihydrofolate reductase; EC 1.5.1.3; 9002-03-3; tetrahydrofolate dehydrogenase; DHFR; pteridine reductase:dihydrofolate reductase; dihydrofolate reductase:thymidylate synthase; thymidylate synthetase-dihydrofolate reductase; folic acid reductase; folic reductase; dihydrofolic acid reductase; dihydrofolic reductase; 7,8-dihydrofolate reductase; NADPH-dihydrofolate reductase. Cat No: EXWM-1511. | |
| Dihydrofolate Reductase from human, Recombinant | Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in 1-carbon transfer chemistry. In humans, the DHFR enzyme is encoded by the DHFR gene. It is found in the q11?q22 region of chromosome 5. Bacterial species possesses distinct DHFR enzymes (based on their pattern of binding diaminoheterocyclic molecules), but mammalian DHFRs are highly similar. Human dhfr is an 186 amino acid protein with an apparent molecular weight of 25 kda. it is 30% homologous to the e. coli protein and up to 70% homologous to vertebrate protein... from mycobacterium smegmatis. human dihydrofolate reductase has been used in a study to investigate the stable expression of green fluorescent protein and the targeted disruption of thioredoxin peroxidase-1 gene in babesia bovis. human dihydrofolate reductase has also been used in a study to investigate the structural analysis of human dihydrofolate reductase as a binary complex. Group: Enzymes. Synonyms: DHFR; dihydrofolate reductase; DYR; DHFRP1; Tetrahydrofolate NADP+ oxidoreductase; EC 1.5.1.3; tetrahydrofolate dehydrogenase; pteridine reductase:dihydrofolate reductase; dihydrofolate reductase:thymidylate synthase; thymidylate synthetase-dihydrofolate reductase; f | |
| dithymidine 3',5'-phosphate | Dithymidine 3',5'-phosphate, a biochemical of great scientific significance, features prominently in research circles as it allows the study of protein-DNA interactions and enzyme reactions. In addition, its synthesis of oligonucleotides proves instrumental in analyzing nucleic acid metabolism and DNA repair pathways. Its versatile properties make it an essential instrument of contemporary scientific pursuit. Synonyms: d(Tpt); thymidylyl(3'-5')thymidine; dTpdT DNA Dinucleotide (5'-3'). Grades: ≥95% by AX-HPLC. Molecular formula: C20H27N4O12P. Mole weight: 546.40. | |
| D-Pemetrexed Dimethyl Diester | D-Pemetrexed dimethyl diester is one of pemetrexed impurities. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid 1,5-Dimethyl Diester. Grades: 98%. CAS No. 1391068-12-4. Molecular formula: C22H25N5O6. Mole weight: 455.46. | |
| D-Pemetrexed Hydrate | D-Pemetrexed Hydrate is one of pemetrexed impurities. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-D-glutamic Acid Hydrate. Molecular formula: C20H23N5O7. Mole weight: 445.42. | |
| Edatrexate | Edatrexate is a polyglutamatable folate antagonist analogue of methotrexate with antineoplastic activity. Edatrexate inhibits dihydrofolate reductase, thereby increasing cellular levels of polyglutamates, inhibiting thymidylate synthase and glycinamide ribonucleotide formyl transferase, impairing synthesis of purine nucleotides and amino acids, and resulting in tumor cell death. Edatrexate may overcome tumor resistance to methotrexate, which loses its activity after it is polyglutamated. Uses: Antineoplastic agents. Synonyms: 10-ethyl-deaza-aminopterin; 10-EDAM; 10 EDAM; 10EDAM; CGP-30694; CGP30694; CGP30694; D 03942; D-03942; D03942. CAS No. 80576-83-6. Molecular formula: C22H25N7O5. Mole weight: 467.49. | |
| FdUTP | FdUTP, a remarkable nucleoside triphosphate, puts the brakes on thymidylate synthase, striking a fatal blow to DNA precursor synthesis and culminating in cellular collapse. This versatile substance has proven tadpole in tackling a gamut of solid tumors, from the grisly colorectal specter to the dauntingly defiant breast cancer. Synonyms: 5-Fluoro-2'-deoxyuridine-5'-triphosphate. Grades: ≥ 95 % (HPLC). Molecular formula: C9H14N2O14P3F (free acid). Mole weight: 486.1 (free acid). | |
| galactose-1-phosphate thymidylyltransferase | This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is dTTP:alpha-D-galactose-1-phosphate thymidylyltransferase. Other names in common use include dTDP galactose pyrophosphorylase, galactose 1-phosphate thymidylyl transferase, thymidine diphosphogalactose pyrophosphorylase, thymidine triphosphate:alpha-D-galactose 1-phosphate, and thymidylyltransferase. This enzyme participates in nucleotide sugars metabolism. Group: Enzymes. Synonyms: dTDP galactose pyrophosphorylase; galactose 1-phosphate thymidylyl transferase; thymidine diphosphogalactose pyrophosphorylase; thymidine triphosphate:α-D-galactose 1-phosphate thymidylyltransferase. Enzyme Commission Number: EC 2.7.7.32. CAS No. 9023-25-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3243; galactose-1-phosphate thymidylyltransferase; EC 2.7.7.32; 9023-25-0; dTDP galactose pyrophosphorylase; galactose 1-phosphate thymidylyl transferase; thymidine diphosphogalactose pyrophosphorylase; thymidine triphosphate:α-D-galactose 1-phosphate thymidylyltransferase. Cat No: EXWM-3243. | |
| glucose-1-phosphate thymidylyltransferase | Involved in the biosynthesis of L-rhamnose in bacteria. Group: Enzymes. Synonyms: glucose 1-phosphate thymidylyltransferase; dTDP-glucose synthase; dTDP-glucose pyrophosphorylase; thymidine diphosphoglucose pyrophosphorylase; thymidine diphosphate glucose pyrophosphorylase; TDP-glucose pyrophosphorylase. Enzyme Commission Number: EC 2.7.7.24. CAS No. 9026-3-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3237; glucose-1-phosphate thymidylyltransferase; EC 2.7.7.24; 9026-03-3; glucose 1-phosphate thymidylyltransferase; dTDP-glucose synthase; dTDP-glucose pyrophosphorylase; thymidine diphosphoglucose pyrophosphorylase; thymidine diphosphate glucose pyrophosphorylase; TDP-glucose pyrophosphorylase. Cat No: EXWM-3237. | |
| Hydroxyethyl disulfide | Hydroxyethyl disulfide blocks the inhibitory effect of showdomycin on methotrexate-resistant thymidylate synthase and is also protected by its substrate deoxyuridylic acid, preventing inactivation of the antibiotic [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1892-29-1. Pack Sizes: 1 g; 5 g; 10 g. Product ID: HY-W076898A. | |
| Lufepirsen | Lufepirsen is a gap junction alpha-1 protein synthesis reducer. Synonyms: 2'-deoxyguanylyl-(3'?5')-thymidylyl-(3'?5')-2'-deoxyadenylyl-(3'?5')-2'-deoxyadenylyl-(3'?5')-thymidylyl-(3'?5')-thymidylyl-(3'?5')-2'-deoxyguanylyl-(3'?5')-2'-deoxycytidylyl-(3'?5')-2'-deoxyguanylyl-(3'?5')-2'-deoxyguanylyl-(3'?5')-2'-deoxycytidylyl-(3'?5')-2'-deoxyadenylyl-(3'?5')-2'-deoxyadenylyl-(3'?5')-2'-deoxyguanylyl-(3'?5')-2'-deoxyadenylyl-(3'?5')-2'-deoxyadenylyl-(3'?5')-2'-deoxyguanylyl-(3'?5')-2'-deoxyadenylyl-(3'?5')-2'-deoxyadenylyl-(3'?5')-thymidylyl-(3'?5')-thymidylyl-(3'?5')-2'-deoxyguanylyl-(3'?5')-thymidylyl-(3'?5')-thymidylyl-(3'?5')-thymidylyl-(3'?5')-2'-deoxycytidylyl-(3'?5')-thymidylyl-(3'?5')-2'-deoxyguanylyl-(3'?5')-thymidylyl-(3'?5')-2'-deoxycytidine. CAS No. 287122-58-1. Molecular formula: C296H371N112O180P29. Mole weight: 9276.09. | |
| (-)-LY-338979 | (-)-LY-338979 is one of pemetrexed metabolites. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: (S)-2-(4-(2-((R)-2-amino-4,6-dioxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid; (4-(2-((R)-2-amino-4,6-dioxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoyl)-L-glutamic acid; N-(4-{2-[(5R)-2-Amino-4,6-dioxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl]ethyl}benzoyl)-L-glutamic acid; L-Glutamic acid, N-[4-[2-[(5R)-2-amino-4,5,6,7-tetrahydro-4,6-dioxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl]ethyl]benzoyl]-. Molecular formula: C20H21N5O7. Mole weight: 443.41. | |
| (+)-LY-338979 | (+)-LY-338979 is one of pemetrexed metabolites. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: (S)-2-(4-(2-((S)-2-amino-4,6-dioxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid; (4-(2-((S)-2-amino-4,6-dioxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoyl)-L-glutamic acid; N-(4-{2-[(5S)-2-Amino-4,6-dioxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl]ethyl}benzoyl)-L-glutamic acid; L-Glutamic acid, N-[4-[2-[(5S)-2-amino-4,5,6,7-tetrahydro-4,6-dioxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl]ethyl]benzoyl]-. Molecular formula: C20H21N5O7. Mole weight: 443.41. | |
| LY-338979 Dimethyl Ester | LY-338979 dimethyl ester is one of pemetrexed metabolites. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: Dimethyl N-{4-[2-(2-amino-4,6-dioxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate; N-[4-[2-(2-Amino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid 1,5-Dimethyl Ester; L-Glutamic acid, N-[4-[2-(2-amino-4,5,6,7-tetrahydro-4,6-dioxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, dimethyl ester. Grades: ≥95%. CAS No. 1320346-45-9. Molecular formula: C22H25N5O7. Mole weight: 471.46. | |
| LY 368962 Dimethyl Ester | LY 368962 dimethyl ester is one of pemetrexed metabolites. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: Dimethyl N-{4-[3-(2,6-diamino-4-oxo-1,4-dihydro-5-pyrimidinyl)-3-oxopropyl]benzoyl}-L-glutamate; L-Glutamic acid, N-[4-[3-(2,6-diamino-1,4-dihydro-4-oxo-5-pyrimidinyl)-3-oxopropyl]benzoyl]-, dimethyl ester; N-[4-[3-(2,6-Diamino-1,4-dihydro-4-oxo-5-pyrimidinyl)-3-oxopropyl]benzoyl]-L-glutamic Acid Dimethyl Ester; Dimethyl (4-(3-(2,6-diamino-4-oxo-1,4-dihydropyrimidin-5-yl)-3-oxopropyl)benzoyl)-L-glutamate. Grades: 98%. CAS No. 1798887-66-7. Molecular formula: C21H25N5O7. Mole weight: 459.45. | |
| N-2-[(Dimethylamino)methylene]amino Pemetrexed | N-2-[(Dimethylamino)methylene]amino pemetrexed is one of pemetrexed impurities. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: Pemetrexed N,N-Dimethyl Form Amide Impurity; (4-(2-(2-(((dimethylamino)methylene)amino)-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoyl)-L-glutamic acid. Grades: 98%. CAS No. 1265908-58-4. Molecular formula: C23H26N6O6. Mole weight: 482.49. | |
| N-[4-[3-[2-Amino-4-(formylamino)-1,6-dihydro-6-oxo-5-pyrimidinyl]-3-oxopropyl]benzoyl]-L-glutamic Acid | N-[4-[3-[2-Amino-4-(formylamino)-1,6-dihydro-6-oxo-5-pyrimidinyl]-3-oxopropyl]benzoyl]-L-glutamic acid is one of pemetrexed impurities. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: Pemetrexed Seco-indolone; (S)-2-(4-(3-(2-Amino-4-formamido-6-oxo-1,6-dihydropyrimidin-5-yl)-3-oxopropyl)benzamido)pentanedioic acid; Pemetrexed Impurity 20. Grades: 98%. CAS No. 1644286-35-0. Molecular formula: C20H21N5O8. Mole weight: 459.41. | |
| N-Methyl Pemetrexed | N-Methyl Pemetrexed (Pemetrexed EP Impurity A) is an impurity of Pemetrexed, an multitargeted antifolate that inhibits thymidylate synthase as well as other folate dependent enzymes. Group: Biochemicals. Alternative Names: N-[4-[2-(2-Amino-4,7-dihydro-1-methyl-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid; Pemetrexed EP Impurity A. Grades: Highly Purified. CAS No. 869791-42-4. Pack Sizes: 2.5mg. Molecular Formula: C??H??N?O?, Molecular Weight: 441.44. US Biological Life Sciences. | Worldwide |
| N-Methyl Pemetrexed Dimethyl Ester | N-Methyl pemetrexed dimethyl ester is one of pemetrexed intermediates. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: Pemetrexed N-Methyl Dimethyl Ester; N-[4-[2-(2-Amino-4,7-dihydro-1-methyl-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl] L-Glutamic Acid 1,5-Dimethyl Ester. Molecular formula: C23H27N5O6. Mole weight: 469.49. | |
| N-Methyl Pemetrexed L-Glutamic Acid | N-Methyl Pemetrexed L-glutamic acid is one of pemetrexed intermediates. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: N-{4-[2-(2-Amino-1-methyl-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-γ-glutamyl-L-glutamic acid; L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-1-methyl-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-γ-glutamyl-. Molecular formula: C26H30N6O9. Mole weight: 570.55. | |
| Nolatrexed | Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity. Uses: Antimetabolites, antineoplastic. Synonyms: 2-amino-6-methyl-5-(pyridin-4-ylthio)quinazolin-4(3H)-one; NSC648316. CAS No. 147149-76-6. Molecular formula: C14H12N4OS. Mole weight: 284.34. | |
| Nolatrexed dihydrochloride | Nolatrexed, also known as AG337, is a thymidylate synthase inhibitor with potential anticancer activity. A phase II study of nolatrexed in 2007 in advanced HCC patients demonstrated minimal activity and significant stomatitis. Synonyms: AG 337; Thymitaq; 2-Amino-6-methyl-5-(4-pyridinylthio)-4(1H)-quinazolinone Hydrochloride; 2-amino-6-methyl-5-(pyridin-4-ylsulfanyl)-1,4-dihydroquinazolin-4-one dihydrochloride; 3,4-Dihydro-2-amino-6-methyl-4-oxo-5-(4-pyridylthio)quinazoline dihydrochloride. Grades: 98%. CAS No. 152946-68-4. Molecular formula: C14H14Cl2N4OS. Mole weight: 357.25. | |
| Nolatrexed dihydrochloride | Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase. Nolatrexed dihydrochloride (AG 337) induces cell cycle arrest in S phase of cancer cells. Anti-cancer activity. Group: Inhibitors. Alternative Names: Nolatrexed dihydrochloride. CAS No. 152946-68-4. Molecular formula: C14H12N4OS?2(HCl). Mole weight: 357.26. Appearance: Tan Solid. Purity: ≥98%. Canonical SMILES: [H]Cl. O=C1N=C (N)NC2=C1C (SC3=CC=NC=C3)=C (C)C=C2. [H]Cl. Density: g/cm³. Catalog: ACM152946684. | |
| Nolatrexed dihydrochloride | Nolatrexed dihydrochloride (AG 337) is an orally active and non-competitive lipophilic inhibitor of thymidylate synthase with a K i of 11 nM for human thymidylate synthase. Nolatrexed dihydrochloride interacts at the folate cofactor binding site of the enzyme. Nolatrexed dihydrochloride increases sulfotransferases. Nolatrexed dihydrochloride induces cell cycle arrest in S phase of cancer cells. Nolatrexed dihydrochloride exhibits anticancer activity against cervical cancer. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AG 337. CAS No. 152946-68-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-108474. | |
| Nolatrexed Dihydrochloride | Antifolate thymidylate synthase inhibitor. Antineoplastic. Group: Biochemicals. Alternative Names: 2-Amino-6-methyl-5-(4-pyridinylthio)-4(1H)-quinazolinone Hydrochloride; AG 337; Thymitaq. Grades: Highly Purified. CAS No. 152946-68-4. Pack Sizes: 10mg, 25mg, 50mg. US Biological Life Sciences. | Worldwide |
| OSI-7904L | OSI-7904L, also known as GW1843, OVI-237, GS7904L, is a potent, 3-methyl-substituted benzoquinazoline folate analog very specific for thymidylate synthase. Uses: Antineoplastic agents. Synonyms: GS7904L; GW1843; GW 1843; GW-1843; 1843U89; OVI-237; OVI 237; OVI237. CAS No. 139987-54-5. Molecular formula: C27H24N4O6. Mole weight: 500.51. | |
| PD 130883 | This active molecular is a potent lipophilic quinazoline antifolate and data show that marked PD130883 suppression of thymidylate synthase slows the rate but not the extent of tetrahydrofolate cofactor interconversion to dihydrofolate upon complete suppression of dihydrofolate reductase with trimetrexate. Synonyms: CHEMBL62769;123685-36-9;2-Amino-6-(((4-nitrophenyl)-2-propynylamino)methyl)-4(3H)quinazolinone;4(3H)-Quinazolinone,2-amino-6-[[(4-nitrophenyl)-2-propyn-1-ylamino]methyl]-;ACMC-20mqpf;PD-130883; PD130883; PD 130883. Grades: 95%. CAS No. 123685-36-9. Molecular formula: C18H15N5O3. Mole weight: 349.34. | |
| Pemetrexed | Pemetrexed (LY231514) is an antifolate , the K i values of the pentaglutamate of Pemetrexed (LY231514) are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase ( TS ), dihydrofolate reductase ( DHFR ), and glycinamide ribonucleotide formyltransferase ( GARFT ), respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY231514. CAS No. 137281-23-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-10820. | |
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