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TMP-153 is an Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor with IC50 values of 5-10 nM in various animals. It inhibits cholesterol esterification both in human colonic adenocarcinoma cells, LS180, and in human hepatoma cells, HepG2 (IC50 = 150 nM and 330 nM, respectively). Synonyms: N-(4-(2-Chlorophenyl)-6,7-dimethyl-3-quinolyl)-N'-(2,4-difluorophenyl)urea; 1-[4-(2-chlorophenyl)-6,7-dimethylquinolin-3-yl]-3-(2,4-difluorophenyl)urea. Grades: ≥95%. CAS No. 128831-46-9. Molecular formula: C24H18ClF2N3O. Mole weight: 437.9.
TMP195
TMP195 is a selective class IIa histone deacetylase (HDAC) inhibitor (IC50s = 59 nM, 60 nM, 26 nM and 15 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively), and is >100 fold selective over other HDACs (IC50 >10 μM). Synonyms: TMP195; TMP-195; TMP 195; N-[2-methyl-2-(2-phenyl-1,3-oxazol-4-yl)propyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide; N-(2-Methyl-2-(2-phenyloxazol-4-yl)propyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide; N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMide; TFMO 2. CAS No. 1314891-22-9. Molecular formula: C23H19F3N4O3. Mole weight: 456.42.
TMP269 is a highly potent, selective and cell-permeable class IIa HDAC inhibitor with IC50 values of 126 nM, 80 nM, 36 nM and 19 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively. Synonyms: TMP269; TMP 269; TMP-269; N-((4-(4-Phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide. Grades: 98%. CAS No. 1314890-29-3. Molecular formula: C25H21F3N4O3S. Mole weight: 514.523.
TMP778
TMP778 is a selective RORγt inverse agonist. TMP778 can selectively block mouse Th17 cell differentiation in vitro and impair Th17 cell development in vivo upon immunization with the myelin antigen MOG35-55 plus complete Freund's adjuvant. In addition, TMP778 can repress the expression of more than 150 genes, most of which fall outside the canonical Th17 transcriptional signature and are linked to a variety of inflammatory pathologies in humans. Synonyms: TMP778; TMP 778; TMP-778; 2- (2- ( (S)- (3, 5-dimethylisoxazol-4-yl) (hydroxy)methyl)benzofuran-5-yl)-N- ( (S)- (2, 4-dimethylphenyl) (phenyl)methyl)acetamide. Grades: 98%. CAS No. 1422171-08-1. Molecular formula: C31H30N2O4. Mole weight: 494.59.
TMPA
TMPA is a high-affinity Nur77 antagonist that binds to Nur77 leading to the release and shuttling of LKB1 in the cytoplasm to activate AMPK&alpha. TMPA effectively lowers blood glucose and attenuates insulin resistance in type II db/db, high-fat diet and streptozotocin-induced diabetic mice. TMPA reduces RICD (restimulation-induced cell death) in human T cells, can also be used in studies of cancer and T-cell apoptosis dysregulation [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1258275-73-8. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18555.
TMPA
TMPA is an antagonist of nuclear receptor Nur77 (Kd = 1.45 ± 0.35 μM) and LKB1 interaction. Synonyms: ethyl 2-(2,3,4-trimethoxy-6-octanoylphenyl)acetate; ethyl 2-(2,3,4-trimethoxy-6-(1-octanoyl)phenyl)acetate. CAS No. 1258275-73-8. Molecular formula: C21H32O6. Mole weight: 380.48.
TMP-CP
TMP-CP is a non-hydrolytic analogue of thymidine-5'-diphosphate and an inhibitor of thymidine kinase. It is also used as a starting structure in the synthesis of α/β hydrolysis-resistant tri- and polyphosphates. Synonyms: Thymidine- 5'- O- (α, β- methylene)diphosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 55065-40-2. Molecular formula: C11H18N2O10P2 (free acid). Mole weight: 400.2 (free acid).
TMPD dihydrochloride
TMPD dihydrochloride, a readily oxidizable compound, is an enzymatically convert redox active substrate molecule. TMPD dihydrochloride is also an electron donor and serves as a reducing cosubstrate for heme peroxidases [1] [2]. TMPD dihydrochloride is also a complex IV substrate [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 637-01-4. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-W012145.
TMPEOTA 28961-43-5
TMPEOTA 28961- - Surface Coatings. SUPPLIERS TO BUSINESS CUSTOMERS ONLY.
North America & APAC
TMPH hydrochloride
TMPH hydrochloride is a potent and non-competitive antagonist of neuronal nicotinic ACh receptors (nAChRs). It produces long-lasting inhibition of neuronal nAChRs formed by the combination of the most abundant α and β subunits (i.e. α3, α4 and β2, β4 respectively). TMPH hydrochloride has the potential to treat progressive neurodegenerative disease such as globoid cell leukodystrophy (GLD) or Krabbe disease. Synonyms: 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate. Grades: ≥98% by HPLC. CAS No. 849461-91-2. Molecular formula: C16H31NO2.HCl. Mole weight: 305.88.
TMPH inhibitor
TMPH is an inhibitor of CNS nicotinic receptor. Evaluation of nicotinic acetylcholine receptor (nAChR) subunits expressed in Xenopus laevis oocytes indicated that TMPH can produce a potent and long-lasting inhibition of neuronal nAChR formed by the pairwise combination of the most abundant neuronal α (i.e., α3 and α4) and β subunits (β2 and β4), with relatively little effect, because of rapid reversibility of inhibition, on muscle-type (α1β1γδ) or α7 receptors. Uses: Designed for use in research and industrial production. Additional or Alternative Names: TMPH; TMPH inhibitor. Product Category: Inhibitors. Appearance: To be determined. CAS No. 849461-90-1. Molecular formula: C16H31NO2. Mole weight: 269.43. Purity: >98%. IUPACName: 2,2,6,6-Tetramethyl-4-piperidinyl heptanoate. CanonicalSMILES: CCCCCCC(OC1CC(C)(C)NC(C)(C)C1)=O. Product ID: ACM849461901-1. Alfa Chemistry: Alfa Chemistry ISO 9001:2015 Certified. Categories: TPH inhibitor.
TmPPPyTz
TmPPPyTz. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2,4,6-Tris(3'-(pyridin-3-yl)biphenyl-3-yl)-1,3,5-triazine. Product Category: Organic Light Emitting Diode (OLED). CAS No. 939430-31-6. Molecular formula: C54H36N6. Mole weight: 768.9 g/mol. Product ID: ACM939430316. Alfa Chemistry: Alfa Chemistry ISO 9001:2015 Certified.
TMPTA
1kg Pack Size. Group: Building Blocks, Organics. Formula: C15H20O6. CAS No. 15625-89-5. Prepack ID 90027098-1kg. Molecular Weight 296.32. See USA prepack pricing.
TMPTA
500g Pack Size. Group: Building Blocks, Organics. Formula: C15H20O6. CAS No. 15625-89-5. Prepack ID 90027098-500g. Molecular Weight 296.32. See USA prepack pricing.
TMPyP4 tosylate. Group: Biochemicals. Grades: Purified. CAS No. 36951-72-1. Pack Sizes: 50mg. US Biological Life Sciences.
Worldwide
TMPyP4 tosylate
TMPyP4 tosylate is a cationic porphyrin. TMPyP4 stacks with G tetrads to stabilize quadruplex DNA, and inhibits telomerase activity (IC50 ≤ 50 μM). TMPyP4 inhibits cell proliferation and induces apoptosis in three myeloma cell lines. Synonyms: 5,10,15,20-Tetrakis(1-methylpyridinium-4-yl)porphyrin tetra(p-toluenesulfonate); Tmpyp tetratosylate. Grades: ≥95% by HPLC. CAS No. 36951-72-1. Molecular formula: C72H66N8O12S4. Mole weight: 1363.6.
TMPyP4 Tosylate
TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand. TMPyP4 tosylate inhibits the interaction between G-quadruplexes and IGF-1. TMPyP4 tosylate is a telomerase inhibitor and inhibits cancer cells proliferation. TMPyP4 tosylate is also a stabilizer of nucleic acid secondary structure and an acetylcholinesterase inhibitor. Besides, TMPyP4 tosylate has antiviral activity against SARS-CoV-2. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Meso-Tetrakis(N-Methyl-4-Pyridyl)Porphine Tetrakis(P-Toluenesulfonate). Product Category: Inhibitors. Appearance: Soild. CAS No. 36951-72-1. Molecular formula: C72H74N8O12S4. Mole weight: 1371.66. Purity: 0.98. Product ID: ACM36951721-4. Alfa Chemistry: Alfa Chemistry ISO 9001:2015 Certified.
TmPyPB
TmPyPB. Uses: Electron-transport and hole/exciton-blocking materail with high electron mobility (10-4-10-3 cm2 v-1 s-1) and high triplet energy level (2.75 ev) for highly efficient phosphorescent oleds application. Group: Organic light-emitting diode (oled) materials. Alternative Names: 1,3,5-Tri(m-pyridin-3-ylphenyl)benzene,1,3,5-Tris(3-pyridyl-3-phenyl)benzene,Tm3PyPB. CAS No. 921205-03-0. Pack Sizes: 1, 5 g in glass bottle. Product ID: 3-[3-[3,5-bis(3-pyridin-3-ylphenyl)phenyl]phenyl]pyridine. Molecular formula: 537.65. Mole weight: C39H27N3. C1 (C2=CC=CC (C3=CN=CC=C3)=C2)=CC (C4=CC=CC (C5=CN=CC=C5)=C4)=CC (C6=CC=CC (C7=CN=CC=C7)=C6)=C1. 1S/C39H27N3/c1-7-28 (34-13-4-16-40-25-34)19-31 (10-1)37-22-38 (32-11-2-8-29 (20-32)35-14-5-17-41-26-35)24-39 (23-37)33-12-3-9-30 (21-33)36-15-6-18-42-27-36/h1-27H, CINYXYWQPZSTOT-UHFFFAOYSA-N. CINYXYWQPZSTOT-UHFFFAOYSA-N.
5'-TMPS
5'-TMPS is a potent, competitive inhibitor that regulates enzymes. It can interact with thymidine-5'-monophosphate. Synonyms: Thymidine- 5'- O- monophosphorothioate, sodium salt. Grades: ≥ 97% by HPLC. CAS No. 15548-51-3. Molecular formula: C10H15N2O7PS (free acid). Mole weight: 338.3 (free acid).
ACP-TMP
ACP-TMP is a derivative of Trimethoprim, which inhibits the enzyme dihydrofolate reductase. Synonyms: 3-Chloro-N- (17- (4- ( (2, 4-diaminopyrimidin-5-yl) methyl) -2, 6-dimethoxyphenoxy) -15-oxo-4, 7, 10-trioxa-14-azaheptadecyl) -4- ( (2- (2-methyl-2- ( (5- (trifluoromethyl) pyridin-2-yl) sulfonyl) propanamido) ethyl) thio) benzamide; Acp-tmp. Molecular formula: C45H58ClF3N8O11S2. Mole weight: 1043.57.
dTMP kinase
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:dTMP phosphotransferase. Other names in common use include thymidine monophosphate kinase, thymidylate kinase, thymidylate monophosphate kinase, thymidylic acid kinase, thymidylic kinase, deoxythymidine 5'-monophosphate kinase, TMPK, and thymidine 5'-monophosphate kinase. This enzyme participates in pyrimidine metabolism. Group: Enzymes. Synonyms: thymidine monophosphate kinase; thymidylate kinase; thymidylate monophosphate kinase; thymidylic acid kinase; thymidylic kinase; deoxythymidine 5'-monophosphate kinase; TMPK; thymidine 5'-monophosphate kinase. Enzyme Commission Number: EC 2.7.4.9. CAS No. 9014-43-1. TMPK. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3219; dTMP kinase; EC 2.7.4.9; 9014-43-1; thymidine monophosphate kinase; thymidylate kinase; thymidylate monophosphate kinase; thymidylic acid kinase; thymidylic kinase; deoxythymidine 5'-monophosphate kinase; TMPK; thymidine 5'-monophosphate kinase. Cat No: EXWM-3219.
A cell-permeable phenylacetate compound that blocks Nur77 (TR3) LKB1 nuclear-sequestering function by antagonizing against Nur77-LKB1 interaction via direct binding at the LKB1 LBD/ligand binding domain (Kd = 0.14 against 5uM LKB1 binding to 5uM full-length Nur77). Shown to induce LKB1 Ser428 phosphorylation (10 & 20uM for 6h) and LKB1 nuclear-to-cytosol translocation in hepatic LO2 cells, resulting in enhanced phosphorylations of LKB1 cytosolic effectors AMPKalpha and MARK1/2/3 without affecting Nur77 transactivation activity. Daily i.p. dosing (50mg/kg) is shown to increase liver LKB1 Ser428/AMPKalpha Thr172 phosphorylations in diabetic db/db mice in vivo, effectively improving animal glucose tolerance. Also reported to lower fasting blood glucose level in STZ-treated, high fat diet-fed type II diabetic mice. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
1,2,5-/1,2,7-Trimethylphenanthrene
1,2,5-/1,2,7-Trimethylphenanthrene. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1,2,5-/1,2,7-TRIMETHYLPHENANTHRENE;1,2,5-/1,2,7-TMP. Product Category: Heterocyclic Organic Compound. CAS No. 60490-68-8. Molecular formula: C34H32. Mole weight: 440.62. Product ID: ACM60490688. Alfa Chemistry: Alfa Chemistry ISO 9001:2015 Certified.
2,2,6,6-TETRAMETHYLPIPERIDINOL-4 HYDROCHLORIDE
2,2,6,6-TETRAMETHYLPIPERIDINOL-4 HYDROCHLORIDE. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2,2,6,6-TETRAMETHYLPIPERIDINOL-4 HYDROCHLORIDE;2,2,6,6-TETRAMETHYL-PIPERIDID-4-OL, HYDROCHLORIDE;TMP-OH;TMP-OH HYDROCHLORIDE;TEMPIDOL;TEMPIDOL HYDROCHLORIDE;2,2,6,6-tetramethylpiperidin-4-ol hydrochloride;2,2,6,6-Tetramethylpiperidin-4-ol hydrochloride. Product Category: Heterocyclic Organic Compound. CAS No. 79316-86-2. Molecular formula: C9H20ClNO. Mole weight: 193.71. Purity: min. 98%.TLC (Silufol UV-254, MeOH:NH3(25%) Rf 0.53, development with Dragendorff's reagent); NMR (D2O). Product ID: ACM79316862. Alfa Chemistry: Alfa Chemistry ISO 9001:2015 Certified.
2-Bromoethylamine HBr
2-Bromoethylamine HBr is used in the synthesis of analogs of 5,?10,?15,?20-tetrakis(1-methylpyridinium-4-yl)?porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone. Synonyms: 2-Bromoethylamine Hydrobromide; 1-Amino-2-bromoethane Hydrobromide; 2-Aminoethyl Bromide Hydrobromide; 2-Bromoethylammonium Bromide; β-Bromoethylamine Hydrobromide. Grades: > 95%. CAS No. 2576-47-8. Molecular formula: C2H7Br2N. Mole weight: 204.89.
2-Bromoethylamine hydrobromide
It is used in the synthesis of analogs of 5,?10,?15,?20-tetrakis(1-methylpyridinium-4-yl)?porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-aminoethyl bromide hydrobromide;2-aminoethyl bromide hydrogen bromide;2-bromo-ethylamine hydrogen brom. Product Category: Amines. Appearance: Crystals. CAS No. 2576-47-8. Molecular formula: C2H7Br2N. Mole weight: 204.89. Purity: purum, ≥97.0% (AT). Density: 1.581 g/cm³. ECNumber: 219-924-2. Product ID: ACM2576478. Alfa Chemistry: Alfa Chemistry ISO 9001:2015 Certified.
2-Bromoethylamine Hydrobromide
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,?10,?15,?20-?tetrakis(1-?methylpyridinium-?4-?yl)?porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 2576-47-8. Pack Sizes: 100g, 250g. Molecular Formula: C2H7Br2N. US Biological Life Sciences.
2'-Deoxy-5'-O-DMT-5-fluoro-O4-(2,4,6-trimethylphenyl)uridine 3'-CE phosphoramidite is an essential recompound widely employed in the biomedical sector, serving as a pivotal constituent in the solid-phase synthesis of structurally modified RNA entities. This extraordinary phosphoramidite empowers researchers to seamlessly introduce bespoke modified nucleotides into RNA strands, thereby endowing unprecedented customization opportunities to optimize their structural attributes and harness targeted applications in therapeutic frameworks. Synonyms: O4-(2,4,6-Trimethylphenyl)-5'-Dimethoxytrityl-5-fluoro-2'-deoxyUridine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; TMP-F-dU-CE Phosphoramidite; 2'-Deoxy-5'-O-DMT-5-fluoro-O4-(2,4,6-trimethylphenyl)-D-uridine 3'-CE phosphoramidite; 5'-O-DMT-5-fluoro-O4-(2,4,6-trimethylphenyl)-2'-deoxyuridine 3'-CE phosphoramidite. CAS No. 198080-36-3. Molecular formula: C48H56N4O8PF. Mole weight: 866.97.
3,3',5,5'-Tetramethylbenzidine
TMP is a substrate for horseradish peroxidase (HRP) in immunoassays. Group: Biochemicals. Alternative Names: TMB; Tetramethylbenzidine base. Grades: Highly Purified. CAS No. 54827-17-7. Pack Sizes: 5g, 10g, 25g, 50g, 100g. Molecular Formula: C16H20N2. US Biological Life Sciences.
Worldwide
3,4,7,8-Tetramethyl-1,10-phenanthroline
3,4,7,8-Tetramethyl-1,10-phenanthroline (TMPhen) is an organic molecule commonly used as a ligand or catalyst. It has a wide range of applications in different fields, such as organometallic chemical reactions, electrochemical detection, and organic optoelectronic devices. Due to its excellent performance in fluorescent probes, biosensors and photocatalytic reactions, it has been widely used in research in the fields of chemistry and life sciences. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: TMPhen; 3,4,7,8-Tetramethyl-1,10-phenanthroline. CAS No. 1660-93-1. Pack Sizes: 1 g. Product ID: HY-34515.
4'-Demethylepipodophyllotoxin
4'-Demethylepipodophyllotoxin(4'-DMEP) is a key intermediate compound for the preparation of podophyllotoxin-type anti-cancer drugs; a potent inhibitor of microtubule assembly.IC50 Value: 0.31uM(EC5 0in HL60 cell, MTT assay, 48h); 0.37uM(EC50 in HepG2 cell, MTT assay, 48h) Target: microtubulein vitro: 4-TMP-DMEP showed strong cytotoxicity activity against the above-mentioned five tumor cell lines. The EC50s of 4-TMP-DMEP against these tumor cell lines ranged from 0.24 to 0.11 μM, which were 0.29 to 3618 times lower than that of DMEP.in vivo: Treatment of animals with DMEP (until the end of the experiment), 30 min before TPA treatment, significantly reduced the tumor incidence, tumor volume and the conversion efficiency of papillomas to squamous cell carcinomas. The tumor formation and growth was also delayed by DMEP pre-treatment. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4-Domethylpodophyllotoxin, 4'-demethyl-epi-podophyllotoxin. Product Category: Inhibitors. Appearance: Powder. CAS No. 6559-91-7. Molecular formula: C21H20O8. Mole weight: 400.38. Purity: 0.98. IUPACName: (5S,5aR,8aR,9R)-5-hydroxy-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one. CanonicalSMILES: COC1=CC(=CC(=C1O)OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](C4=CC5=C(C=C24)OCO5)O. Density: 1.446±0.06 g/ml. Product ID: ACM6559917. Alfa Chemistry:
It is a potential inhibitor of mycobacterium tuberculosis monophosphate kinase (TMPKmt). Synonyms: 5'-AZT; 5'-Azido-5'-deoxythymidine; NSC 254064; 5'-N3-5-Me-ddU; 5'-Azido-5-methyl-2',5'-dideoxyuridine; 1-((2R,4S,5R)-5-(azidomethyl)-4-hydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione. Grades: ≥95%. CAS No. 19316-85-9. Molecular formula: C10H13N5O4. Mole weight: 267.24.
AIM-100
AIM-100 is a potent and selective Ack1 tyrosine kinase with IC50 value of 24 nM. AIM-100, not only inhibited Ack1 activation but also able to suppress pTyr267-AR phosphorylation, binding of AR to PSA, NKX3.1, and TMPRSS2 promoters, and inhibit AR transcription activity. Ack1 tyrosine kinase activation correlates with pancreatic cancer progression. Ack1 inhibitors hold promise for therapeutic intervention to inhibit pancreatic tumor growth. Uses: Designed for use in research and industrial production. Additional or Alternative Names: AIM-100; AIM 100; AIM100. Product Category: Others. Appearance: Solid powder. CAS No. 873305-35-2. Molecular formula: C23H21N3O2. Mole weight: 371.44. Purity: >98%. IUPACName: N-[[(2S)-oxolan-2-yl]methyl]-5,6-diphenylfuro[2,3-d]pyrimidin-4-amine. CanonicalSMILES: C12=NC=NC(NC[C@H]3OCCC3)=C1C(C4=CC=CC=C4)=C(C5=CC=CC=C5)O2. Product ID: ACM873305352. Alfa Chemistry: Alfa Chemistry ISO 9001:2015 Certified.
AIM-100
AIM-100 is a small molecule inhibitor of Ack1. It not only inhibited Ack1 activation but also suppressed AKT tyrosine phosphorylation, leading to cell cycle arrest in the G1 phase. It could suppress AR Tyr(267) phosphorylation and its recruitment to the ATM enhancer and suppress pTyr267-AR phosphorylation, binding of AR to PSA, NKX3.1, and TMPRSS2 promoters, and inhibit AR transcription activity. Synonyms: AIM-100; AIM 100; AIM100. Grades: >98%. CAS No. 873305-35-2. Molecular formula: C23H21N3O2. Mole weight: 371.43.
BC-11 hydrobromide
BC-11 hydrobromide is a selective TMPRSS2 inhibitor (TMPRSS2 is a key host cellular factor for viral entry and SARS-CoV-2 pathogenesis), and a selective urokinase ( uPA ) inhibitor ( IC 50 =8.2 μM). BC-11 hydrobromide is cytotoxic to triple-negative MDA-MB231 breast cancer cells. BC-11 hydrobromide is used in research on viral infections and cancer [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 443776-49-6. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-108447.
Nontoxic dendrimers with functional groups for conjugation or additional modifications. Uses: Nontoxic dendrimers for drug delivery, with functional groups for conjugation or additional modifications. Group: Dendrimers. Alternative Names: G5-TMP-Azide. Pack Sizes: 100 mg in glass bottle. Molecular formula: 24291.78.
Bis-MPA (or 2,2-Bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Uses: Dendrimers synthesized from bis-mpa are biodegradable and have low cytotoxicity, making them well suited for use in biological research s. these materials have been used in many s such as signal amplification in bioassays and in drug delivery s. after boc deprotection, amine-functionalized dendrimers can be readily used in edc or dcc coupling reactions with carbonyl-containing compounds to yield highly functionalized materials for a variety of biomedical s. Group: Dendrimers. Alternative Names: Bis-MPA dendrimer, PFD-G2-TMP-NH-BOC, NHBoc functionalized dendrimer. Molecular formula: 3233.54.
bis-MPA-OH dendrimer
Nontoxic dendrimers with functional groups for conjugation or additional modifications. Uses: Nontoxic dendrimers for drug delivery, with functional groups for conjugation or additional modifications. Group: Dendrimers. Alternative Names: G2-TMP-OH. CAS No. 685901-24-0. Pack Sizes: 250 mg in glass bottle. Molecular formula: 1179.21. O=C (OCC (COC (C (COC (C (CO) (CO)C)=O) (COC (C (CO) (CO)C)=O)C)=O) (CC)COC (C (COC (C (CO) (CO)C)=O) (COC (C (CO) (CO)C)=O)C)=O)C (COC (C (CO) (CO)C)=O) (COC (C (CO) (CO)C)=O)C. 1S/C51H86O30/c1-11-51 (30-79-39 (70)48 (8, 24-73-33 (64)42 (2, 12-52)13-53)25-74-34 (65)43 (3, 14-54)15-55, 31-80-40 (71)49 (9, 26-75-35 (66)44 (4, 16-56)17-57)27-76-36 (67)45 (5, 18-58)19-59)32-81-41 (72)50 (10, 28-77-37 (68)46 (6, 20-60)21-61)29-78-38 (69)47 (7, 22-62)23-63/h52-63H, 11-32H2, 1-10H3. JPMXKQHBVULZDX-UHFFFAOYSA-N.
Bromhexine hydrochloride
Bromhexine hydrochloride is a potent and specific TMPRSS2 protease inhibitor with an IC 50 of 0.75 μM. Bromhexine hydrochloride can prevent and manage SARS-CoV-2 infection. Bromhexine hydrochloride is an autophagy agonist. Bromhexine hydrochloride is a mucolytic cough suppressant and has the potential for a range of respiratory conditions [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 611-75-6. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g; 10 g. Product ID: HY-B0372A.
Camostat mesylate
Camostat mesylate (Camostat mesilate) is an orally active, synthetic serine protease inhibitor for chronic pancreatitis. Camostat mesylate, an inhibitor of TMPRSS2 , shows antiviral activity against SARS-CoV-2. Camostat mesylate also inhibits the activity of prostasin, trypsin, and matriptase [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Camostat mesilate; FOY305; FOY-S980. CAS No. 59721-29-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13512.
Camostat Mesylate
Orally active, non-peptide proteolitic enzyme inhibitor with anti-trypsin and anti-plasmin activities, related structurally to gabexate. Protease inhibitor. Camostat mesilate is a serine protease inhibitor that inhibits plasmin, kallikrein, thrombin as well as trypsin, which attenuates pancreatic fibrosis. It reduces weight gain and improves metabolism in obese rodent models. It is in clinical use (in Japan) for pancreatitis. Camostat has been found to inhibit influenza virus replication in human tracheal epithelial cells and is also a direct prostasin inhibitor which may be useful in reducing sodium transport in cystic fibrosis. Additionally it has been shown to reduce infection of Calu-3 lung cells by SARS-CoV-2 (the coronavirus responsible for COVID-19) via inhibition of the serine protease TMPRSS2 required for viral spike protein priming. Group: Biochemicals. Alternative Names: 4- [ [4- [ (Aminoiminomethyl) amino] benzoyl] oxy] benzeneacetic Acid 2-(Dimethylamino)-2-oxoethyl Ester Methanesulfonate; FOY 305; FOY-S 980; Foipan. Grades: Highly Purified. CAS No. 59721-29-8. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C??H??N?O?S. US Biological Life Sciences.
Δ4-Abiraterone (D4A) is an active metabolite of the CYP17A1 inhibitor abiraterone (Item No. 9002768).1 D4A is an androgen receptor antagonist (IC50 = 5.3 nM) that reduces expression of the androgen receptor target genes PSA, TMPRSS2, and FKBP5 in LNCaP, LAPC4, and C4-2 cell lines. It inhibits the cytochrome P450 (CYP) isoform CYP17A1 by 66.5% when used at a concentration of 1 nM. D4A (10 μM) also blocks SRD5A conversion of Δ4-androstenedione to 5α-androstanedione in LAPC4 cells. In vivo, D4A delays tumor progression in a VCaP mouse xenograft model and increases progression-free survival in a C4-2 mouse xenograft model. Synonyms: CB 7627; D4A. Grades: ≥98%. CAS No. 154229-21-7. Molecular formula: C24H29NO. Mole weight: 347.49.
EMERY® E 6919
Trimethylolpropane oleate. Uses: Bio-diluent, solvent or plasticizer, cleaning and stripping products, plastic additive, metal working fluid, release agent, replacement for mineral, vegetable and selected silicone oils. Group: Fatty acid ester. Alternative Name: TMP oleate. Grade: Technical. Pack Sizes: Drums, Bulk Liquid (Truck & Rail).
(±)-Hexanoylcarnitine chloride is a fatty acid metabolite that breaks down fatty acids into energy that can be used by the body. (±)-Hexanoylcarnitine chloride also serves as a specific and easily detectable biomarker for rat skeletal muscle toxicity. Cerivastatin (HY-129458) and TMPD (HY-W012145) induce an increase in Hexanoylcarnitine in rats in a metabolomic analysis of the rectus femoris muscle. In type 2 diabetes, Hexanoylcarnitine is also significantly associated with and improves prediction of all-cause mortality. Hexanoylcarnitine is a biomarker for the identification of novel pathogenic pathways [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: DL-Hexanoylcarnitine chloride. CAS No. 6920-35-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100978.
Matriptase-2 from Human, Recombinant
Matriptase-2 (TMPRSS6) is a type II transmembrane serine protease mainly produced by the liver. It acts as a potent negative regulator of hepcidin, a hepatic peptide hormone and integral player in regulating iron homeostasis. Group: Enzymes. Synonyms: Transmembrane protease serine 6; TMPRSS6; Matriptase-2. Enzyme Commission Number: EC 3.4.21.-. Purity: Purified by multi-step chromatography. Matriptase-2. Mole weight: ~84 kDa; a-subunit: ~56kDa; b-subunit: ~28kDa. Activity: ~2.5U/ul. Stability: Stable for at least 6 months when stored at -20°C. Recommended Assay Buffer: 100mM TRIS, pH 9.0, containing 0.5mg/ml BSA. Do not store diluted solutions. Storage: Short Term Storage: -20°C; Long Term Storage: -80°C. Form: Liquid. In 100mM TRIS-HCl, pH 9.0, containing 150 mM sodium chloride and 20% glycerol. Source: Drosophila Schneider 2 (S2) cells. Species: Human. Transmembrane protease serine 6; TMPRSS6; Matriptase-2. Cat No: NATE-0857.
Methyl 3,4,5-trimethoxybenzoate
Methyl 3,4,5-trimethoxybenzoate can be synthesized from Gallic acid. Methyl 3,4,5-trimethoxybenzoate is mainly used in the production of Trimethoprim (TMP), Sulfa synergistic intermediates, and many other agents. Uses: Scientific research. Group: Natural products. CAS No. 1916-07-0. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-N2044.
Mivebresib
Mivebresib is a BET inhibitor with potential antineoplastic activity. It disrupts critical transcription programs that drive prostate cancer growth to induce potent anti-tumor activity in vitro and in vivo. Mivebresib is also a MYC and the TMPRSS2-ETS fusion proteins inhibitor. Mivebresib can inhibit cell growth in susceptible tumors. Uses: Anti-tumor. Synonyms: ABBV-075; ABBV 075; ABBV075; Mivebresib;N-(4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide. Grades: 98%. CAS No. 1445993-26-9. Molecular formula: C22H19F2N3O4S. Mole weight: 459.47.
N-(2,2,6,6-Tetramethylpiperidin-4-yl)methacrylamide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-Methyl-N-(2,2,6,6-tetramethyl-4-piperidinyl)acrylamide; 4-Methacrylamido-2,2,6,6-tetramethylpiperidine; 2-Methyl-N-(2,2,6,6-tetramethyl-4-piperidinyl)-2-propenamide; TMPMA. Product Category: Acrylamide Monomers. Appearance: White to Light Yellow Powder to Crystal. CAS No. 31582-46-4. Molecular formula: C13H24N2O. Mole weight: 224.35 g/mol. Purity: 98.0%(T)(HPLC). Product ID: ACM-MO-31582464. Alfa Chemistry: Alfa Chemistry ISO 9001:2015 Certified.
Native Human Prostatic Acid Phosphatase
Prostatic acid phosphatase (PAP), also prostatic specific acid phosphatase (PSAP), is an enzyme produced by the prostate. It may be found in increased amounts in men who have prostate cancer or other diseases. The highest levels of acid phosphatase are found in metastasized prostate cancer. Diseases of the bone, such as Paget's disease or hyperparathyroidism, diseases of blood cells, such as sickle-cell disease or multiple myeloma or lysosomal storage diseases, such as Gaucher's disease, will show moderately increased levels. Group: Enzymes. Synonyms: Prostatic acid phosphatase; PAP; prostatic specific acid phosphatase; PSAP; EC 3.1.3.2; ACP; Acid Phos; 5'-nucleotidase; 5'-NT; Ecto-5'-nucleotidase; Thiamine monophosphatase; TMPase; PAPf39. Enzyme Commission Number: EC 3.1.3.2. CAS No. 9001-77-8. Purity: Partially Purified. Apase. Mole weight: 100 kDa. Activity: > 200 U/mL (Dimension Clinical Chemistry System). Appearance: Cloudy, straw colored liquid. Storage: -20°C. Form: Liquid. Source: Human Semen. Species: Human. Prostatic acid phosphatase; PAP; prostatic specific acid phosphatase; PSAP; EC 3.1.3.2; ACP; Acid Phos; 5'-nucleotidase; 5'-NT; Ecto-5'-nucleotidase; Thiamine monophosphatase; TMPase; PAPf39. Cat No: NATE-0505.
N-Desmethyl Enzalutamide
N-desmethyl Enzalutamide is a major metabolite of Enzalutamide. Enzalutamide is an androgen-receptor (AR) antagonist (IC50 = 36 nM) in LNCaP cells that inhibits the transcriptional activity of a mutant AR protein. Enzalutamide resists against induction of prostate-specific antigen (PSA) and transmembrane serine protease 2 (TMPRSS2). N-desmethyl Enzalutamide can be used for the treatment of disorders involving androgen, estrogen and progesterone receptors. Uses: The treatment of disorders involving androgen, estrogen and progesterone receptors. Synonyms: N-desmethylenzalutamide; 1242137-16-1; 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl}-2-fluorobenzamide; 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluorobenzamide; Enzalutamide metabolite. CAS No. 1242137-16-1. Molecular formula: C20H14F4N4O2S. Mole weight: 450.412.
N,N,N,N-Tetramethyl-p-phenylenediamine
N,N,N,N-Tetramethyl-p-phenylenediamine (TMPD) is an redox indicator. N,N,N,N-Tetramethyl-p-phenylenediamine can be used for the research of impairment of cell respiration [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 100-22-1. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-W021358.
N,N,N',N'-tetramethyl-p-phenylenediamine dihydrochloride (CAS# 637-01-4) is a useful compound for membrane-tethering cytochrome c to study its impact on cell death in yeast. Uses: Indicators and reagents. Synonyms: TMPD; 1,4-Benzenediamine, N,N,N',N'-tetramethyl-, dihydrochloride; UNII-66W8HKA51X; Wurster's reagent dihydrochloride; 1,4-Benzenediamine, N,N,N',N'-tetramethyl-, dihydrochloride; 66W8HKA51X; tetramethyl-p-phenylenediamine dihydrochloride; NSC36730;W-104885; Wursters Reagent. Grades: 98 % (HPLC). CAS No. 637-01-4. Molecular formula: C10H18Cl2N2. Mole weight: 237.17.
(N-Succinimidyl oxycarbonyl - methyl ) tri s (2, 4, 6-tri methoxyphenyl ) phosphonium bromide
(N-Succinimidyl oxycarbonyl - methyl ) tri s (2, 4, 6-tri methoxyphenyl ) phosphonium bromide. Group: Biochemicals. Alternative Names: TMPP-ac-OSu, N-succinimidyl [tris (2, 4, 6-trimethoxyphenyl) phosphonio]acetate bromide. Grades: Highly Purified. CAS No. 226409-58-1. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C33H39BrNO13P. US Biological Life Sciences.
Worldwide
Phenyl Chlorothionoformate.
Phenyl Chlorothionoformate is used in the preparation of an bicyclic thymidine analogs as selective inhibitors of Thymidine monophosphate kinase Mycobacterium tuberculosis (TMPKmt). Group: Biochemicals. Alternative Names: Carbonochloridothioic Acid O-Phenyl Ester; Chlorothioformic Acid O-Phenyl Ester; NSC 99103; O-Phenyl Carbonochloridothioate ; O-Phenyl Chlorothiocarbonate; O-Phenyl Chlorothioformate; O-Phenyl Chlorothionoformate; Phenoxythiocarbonyl Chloride; Phenyl Chlorothiocarbonate; Phenyl Chlorothionoformate; Phenyl Thiochloroformate; Phenyl Thionochloroformate; Phenyl Thioxochloroformate. Grades: Highly Purified. CAS No. 1005-56-7. Pack Sizes: 5g. US Biological Life Sciences.
Worldwide
Prostatic acid phosphatase from Human, recombinant
ACPP, also known as prostatic acid phosphatase isoform PAP, is a type I integral membrane protein of the plasma membrane and lysosomes, and a secreted form also exists. The concentration of ACPP is elevated in the circulation of prostate cancer patients, making the enzyme a marker for the progression of prostate cancer. Recombinant human ACPP, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. Group: Enzymes. Synonyms: Prostatic acid phosphatase; PAP; prostatic specific acid phosphatase; PSAP; EC 3.1.3.2; ACP; Acid Phos; 5'-nucleotidase; 5'-NT; Ecto-5'-nucleotidase; Thiamine monophosphatase; TMPase; PAPf39; ACPP; ACP-3, ACP3. Enzyme Commission Number: EC 3.1.3.2. CAS No. 9001-77-8. Purity: > 95% by SDS-PAGE. Apase. Mole weight: 41.8 kDa. Activity: >100,000 units/mg. Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -70°C. Avoid repeated freezing and thawing cycles. Form: Liquid. Source: Baculovirus. Species: Human. Prostatic acid phosphatase; PAP; prostatic specific acid phosphatase; PSAP; EC 3.1.3.2; ACP; Acid Phos; 5'-nucleotidase; 5'-NT; Ecto-5'-nucleotidase; Thiamine monophosphatase; TMPase; PAPf39; ACPP; ACP-3, ACP3. Cat No: NATE-1673.
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