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| Product | Description | |
|---|---|---|
| 4-Hydroxy-all-trans-Retinoic Acid | 4-Hydroxy-all-trans-Retinoic Acid is a metabolite of all-trans Retinoic acid. All-trans Retinoic acid is a metabolite of Vitamin A and ajusts its functions of cellular growth and differentiation. Synonyms: rac all-trans 4-Hydroxy Retinoic Acid; 4-Hydroxyretinoic Acid. CAS No. 66592-72-1. Molecular formula: C20H28O3. Mole weight: 316.44. |  |
| 4-Keto all-trans-Retinoic Acid (4-Keto-Tretinoin) | A metabolite of all-trans-Retinoic Acid, a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). Group: Biochemicals. Alternative Names: 4-Keto-Tretinoin. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. |  Worldwide |
| 4-Keto all-trans-Retinoic acid Methyl Ester | 4-Keto all-trans-Retinoic acid Methyl Ester. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| 4-Keto all-trans-Retinoic Acid Methyl Ester | 4-Keto all-trans-Retinoic Acid Methyl Ester is a derivative of Retinoic acid. Retinoic Acid is a metabolite of Vitamin A and ajusts its functions of cellular growth and differentiation. Synonyms: 4-Oxoretinoic Acid Methyl Ester; Methyl 4-Ketoretinoate; Methyl 4-Oxoretinoate. Grades: ≥95%. CAS No. 38030-58-9. Molecular formula: C21H28O3. Mole weight: 328.44. | |
| 5,6-Epoxy-all-trans-Retinoic Acid | 5,6-Epoxy-all-trans-Retinoic Acid is a metabolite of all-trans Retinoic acid. All-trans Retinoic acid is a metabolite of Vitamin A and ajusts its functions of cellular growth and differentiation. Synonyms: all-trans 5,6-Epoxy Retinoic Acid; 5,6-Epoxyretinoic Acid; 2,4,6,8-Nonatetraenoic acid, 3,7-dimethyl-9-(2,2,6-trimethyl-7-oxabicyclo[4.1.0]hept-1-yl)-, (2E,4E,6E,8E)-; 5,6-Epoxy-5,6-dihydroretinoic acid. Grades: ≥95%. CAS No. 13100-69-1. Molecular formula: C20H28O3. Mole weight: 316.43. | |
| all-trans-18-Hydroxy Retinoic Acid | all-trans-18-Hydroxy Retinoic Acid is a hydroxylated metabolite of all-trans-Retinoic Acid. Synonyms: 18-Hydroxy-all-trans-retinoic acid; 18-Hydroxyretinoic acid; Ro 12-4825; 2,4,6,8-Nonatetraenoic acid, 3,7-dimethyl-9-(6,6-dimethyl-2-(hydroxymethyl)-1-cyclohexen-1-yl)-, (E)-; all-trans-9-(2-(Hydroxymethyl)-6,6-dimethyl-1-cyclohexen-1-yl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid. Grades: ≥95%. CAS No. 63531-93-1. Molecular formula: C20H28O3. Mole weight: 316.43. | |
| all-trans-3,4-Didehydro retinoic acid | all-trans-3,4-Didehydro retinoic acid. Group: Biochemicals. Alternative Names: (all-E)-3,7-dimethyl-9-(2,6,6-trimethyl-1,3-cyclohexadien-1-yl)-2,4,6,8-nonatetraenoic acid; 3-Dehydroretinoic acid. Grades: Highly Purified. CAS No. 4159-20-0. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C20H26O2. US Biological Life Sciences. | Worldwide |
| all-trans-3,4-Didehydro Retinoic Acid | all-trans-3,4-Didehydro Retinoic Acid is a Retinoic Acid derivative for the treatment of neuroinflammatory conditions. Synonyms: (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1,3-cyclohexadien-1-yl)-2,4,6,8-nonatetraenoic Acid; 3-Dehydroretinoic Acid; 3,4-Didehydro-all-trans-retinoic Acid; 3,4-Didehydroretinoic Acid; Ro 8-7057; Vitamin A2 Acid; all-trans-Vitamin A2 Acid; all-trans-Vitamin A2 Acid. Grades: 96%. CAS No. 4159-20-0. Molecular formula: C20H26O2. Mole weight: 298.42. | |
| all-trans 4-Keto retinoic acid | all-trans 4-Keto retinoic acid. Group: Biochemicals. Alternative Names: 4-Oxoretinoic acid; 4-Ketoretinoic acid; 4-Oxo-all-trans-retinoic acid. Grades: Highly Purified. CAS No. 38030-57-8. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C20H26O3. US Biological Life Sciences. | Worldwide |
| all-trans 4-Keto Retinoic Acid-(9-methyl)-d3 | A deuterated metabolite of all-trans-Retinoic Acid, a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). Group: Biochemicals. Alternative Names: 4-Oxoretinoic Acid-7-d3; 4-Ketoretinoic Acid-7-d3; 4-Oxo-all-trans-retinoic Acid-7-d3; 4-Oxo-atRA-7-d3; 4-Oxotretinoin-d3; 4-keto-Retinoic Acid-7-d3; Ro 11-4824-7-d3; Ro 12-4824-7-d3; all-trans-4-Oxoretinoic Acid-7-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| all-trans 5,6-Epoxy Retinoic Acid | A metabolite of all-trans Retinoic acid. Group: Biochemicals. Alternative Names: 5,6-Epoxy-5,6-dihydroretinoic Acid; 5,6-Epoxyretinoic Acid. Grades: Highly Purified. CAS No. 13100-69-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| all-trans 5,8-Epoxy Retinoic Acid (Mixture of Diastereomers) | A metabolite of all-trans Retinoic acid. Group: Biochemicals. Alternative Names: (2E,4E,6E)-7-(2,4,5,6,7,7a-Hexahydro-4,4,7a-trimethyl-2-benzofuranyl)-3-methyl-2,4,6-octatrienoic Acid. Grades: Highly Purified. CAS No. 3012-76-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| All-trans retinoic acid | All-trans retinoic acid. CAS No: 302-79-4 |  Sarchem Laboratories New Jersey NJ |
| all-trans Retinoic Acid-d5 Ethyl Ester (3,7-Dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoic Acid-d5 Ethyl Ester, (E)-Ethyl Retinoate-d5) | Retinoic acid derivative. Group: Biochemicals. Alternative Names: 3,7-Dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoic Acid-d5 Ethyl Ester; (E)-Ethyl Retinoate-d5. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| all-trans-Retinoic acid methyl ester | all-trans-Retinoic acid methyl ester. Group: Biochemicals. Grades: Highly Purified. CAS No. 339-16-2. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C21H30O2. US Biological Life Sciences. | Worldwide |
| all-trans Retinoic Acid Methyl Ester | all-trans Retinoic Acid Methyl Ester. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| rac all-trans-13,14-Dihydro Retinoic Acid Ethyl Ester | rac all-trans-13,14-Dihydro Retinoic Acid Ethyl Ester is a dihydro ester derivative of all-trans Retinoic Acid. Synonyms: ethyl (4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-4,6,8-trienoate; Ethyl all-trans-13,14-Dihydro Retinoate. Molecular formula: C22H34O2. Mole weight: 330.50. | |
| rac all-trans 3-Hydroxy Retinoic Acid Ethyl Ester | all-trans Retinoic acid derivative. Group: Biochemicals. Alternative Names: (±)-3-Hydroxy-retinoic Acid Ethyl Ester. Grades: Highly Purified. CAS No. 120674-74-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| rac all-trans 3-Hydroxy Retinoic Acid Ethyl Ester | rac all-trans 3-Hydroxy Retinoic Acid Ethyl Ester is a derivative of all-trans Retinoic acid. Retinoic Acid is a metabolite of Vitamin A and ajusts its functions of cellular growth and differentiation. Synonyms: (±)-3-Hydroxy-retinoic Acid Ethyl Ester; Retinoic acid, 3-hydroxy-, ethyl ester, (±)-. Grades: ≥95%. CAS No. 120674-74-0. Molecular formula: C22H32O3. Mole weight: 344.49. | |
| (11-cis,13-cis)-4-Oxoretinoic Acid | (11-cis,13-cis)-4-Oxoretinoic Acid is an intermediate in the synthesis of all-trans 4-Keto Retinoic Acid (K204980), a metabolite of all-trans-Retinoic Acid, a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). Group: Biochemicals. Grades: Highly Purified. CAS No. 112924-95-5. Pack Sizes: 1mg, 10mg. Molecular Formula: C20H26O3, Molecular Weight: 314.42. US Biological Life Sciences. | Worldwide |
| (1S,2S)-N-[4-[2-(Dimethylamino)-1-(1H-imidazol-1-yl)]propylphenyl]-2-benzothiazolamine | (1S,2S)-N-[4-[2-(Dimethylamino)-1-(1H-imidazol-1-yl)]propylphenyl]-2-benzothiazolamine is an inhibitor of the P450 system, which consists of enzymes involved in the electron transport chain. (1S,2S)-N-[4-[2-(Dimethylamino)-1-(1H-imidazol-1-yl)]propylphenyl]-2-benzothiazolamine is also a potent and selective inhibitor of the all-trans-retinoic acid metabolism. Group: Biochemicals. Grades: Highly Purified. CAS No. 355860-40-1. Pack Sizes: 25mg, 50mg. Molecular Formula: C21H23N5S, Molecular Weight: 377.51. US Biological Life Sciences. | Worldwide |
| 2,2-Dimethylcyclohexanone | 2,2-Dimethylcyclohexanone is a useful synthetic intermediate. It is used as a reagent to prepare 9-cis-retinoic acid ring-demethylated analogs. It is also used to prepare selective Janus kinase inhibitors for the treatment of autoimmune diseases and organ transplant rejection. Group: Biochemicals. Grades: Highly Purified. CAS No. 1193-47-1. Pack Sizes: 250mg, 1g. Molecular Formula: C8H14O. US Biological Life Sciences. | Worldwide |
| 4-Keto Retinal | . Uses: An inactive catabolite of retinoic acid. Synonyms: (2E,4E,6E,8E)-9-(2,6,6-Trimethyl-3-keto-1-cyclohexen-1-yl)-3,7-dimethyl-2,4,6,8-nonatetraen-1-al; 4-Oxo-all-trans-retinal; 4-Oxoretinal; all-trans-4-Oxoretinal. Grades: 96%. CAS No. 33532-44-4. Molecular formula: C20H26O2. Mole weight: 298.42. | |
| 4-Methoxy Retinoic Acid | 4-Methoxy Retinoic Acid is an impurity of Retinoic acid. Retinoic Acid is a metabolite of Vitamin A and ajusts its functions of cellular growth and differentiation. Uses: An impurity contained in samples of all trans-retinoic acid. Synonyms: (+/-)-4-Methoxyretinoic Acid. Grades: 95%. CAS No. 81121-20-2. Molecular formula: C21H30O3. Mole weight: 330.46. | |
| 4-Methoxy Retinoic Acid | An impurity contained in samples of all trans-retinoic acid. Group: Biochemicals. Alternative Names: (+/-)-4-Methoxyretinoic Acid. Grades: Highly Purified. CAS No. 81121-20-2. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| 4-Methoxy Retinoic Acid Methyl Ester | all-trans Retinoic Acid impurity. Group: Biochemicals. Alternative Names: (+/-)-4-Methoxyretinoic Acid. Grades: Highly Purified. CAS No. 163808-81-9. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| 5,8-Monoepoxyretinoic Acid | 5,8-Epoxy-all-trans-Retinoic Acid (Mixture of Diastereomers) is a metabolite of all-trans Retinoic acid. All-trans Retinoic acid is a metabolite of Vitamin A and ajusts its functions of cellular growth and differentiation. Synonyms: 5,8-Epoxyretinoic Acid; 5,8-Epoxy-5,8-dihydroretinoic Acid; (2E,4E,6E)-7-(2,4,5,6,7,7a-hexahydro-4,4,7a-trimethyl-2-benzofuranyl)-3-methyl-2,4,6-octatrienoic Acid. Grades: ≥95%. CAS No. 3012-76-8. Molecular formula: C20H28O3. Mole weight: 316.43. | |
| 9,13-Di-cis-retinoic Acid | 9,13-Di-cis-retinoic Acid is a metabolite of 9-cis Retinoic Acid that induces liver fibrosis through activating transforming growth factor-&beta. Synonyms: (9-cis,13-cis)-Retinoic Acid; (2Z,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenoic acid; Isotretinoin EP Impurity B. CAS No. 5352-74-9. Molecular formula: C20H28O2. Mole weight: 300.44. | |
| AGN 194310 | A high affinity pan-RAR antagonist (AGN194310, K(d) for binding to RARs = 2-5 nM) inhibited colony formation (by 50%) by all three lines at 16-34 nM, and led to a transient accumulation of flask-cultured cells in G1 followed by apoptosis. AGN194310 is 12-22 fold more potent than all-trans retinoic acid (ATRA) against cell lines and also more potent in inhibiting the growth of primary prostate carcinoma cells. The administration of all-trans retinoic acid to VAD mice resulted in a transient reduction in NF-kappaB activity and, conversely, a single dose of the RAR-pan-antagonist, AGN 194310, administered to control mice, led to a marked, transient induction of whole-body luminescence. Mice were treated with AGN194310, a synthetic retinoid that antagonises the physiological function of the three RAR isotypes (alpha, beta, gamma) but does not interact with RXRs. Analyses of the granulocytic lineage using Gr-1, c-Kit and CD11b antibodies, demonstrated that granulocyte numbers were strikingly increased across haemopoietic compartments in all AGN194310-treated mice. A significant increase in the frequency of progenitor cells containing granulocytes was observed in the bone marrow of mice following treatment with AGN194310. Synonyms: AGN194310; AGN-194310; VTP194310; VTP 194310; VTP-194310. Grades: >98%. CAS No. 229961-45-9. Molecular formula: C28H24O2S. Mole weight: 424.55. | |
| AGN 196996 | AGN 196996 is a potent and selective antagonist of RAR&alpha. It has been reported to selectively bind to RARs (retinoic acid receptors) for RARα, RARβ and RAR&gamma. It can inhibit the gene transcription activity which induced by ATRA and other RAR agonists. It shows no activity in transactivation assays, but instead block the gene transcriptional activity induced by ATRA and other RAR agonists. Grades: >98%. CAS No. 958295-17-5. Molecular formula: C24H20BrNO5. Mole weight: 482.32. | |
| all trans-Retinal | All-trans retinal is converted to retinoic acid in vivo by the action of retinal dehydrogenase. Synonyms: (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenal. Grades: > 95 %. CAS No. 116-31-4. Molecular formula: C20H28O. Mole weight: 284.44. | |
| all-trans Retinal (Vitamin A Aldehyde, Retinene, Retinylaldehyde) | Corotenoid component of the visual pigments. All-trans retinal is converted to retinoic acid in vivo by the action of retinal dehydrogenase. Group: Biochemicals. Alternative Names: (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenal; all -trans-Vitamin A Aldehyde; Retinene; Retinylaldehyde. Grades: Highly Purified. CAS No. 116-31-4. Pack Sizes: 500mg, 1g. US Biological Life Sciences. | Worldwide |
| all-trans-retinol 13,14-reductase | The reaction is only known to occur in the opposite direction to that given above, with the enzyme being specific for all-trans-retinol as substrate. Neither all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers are substrates. May play a role in the metabolism of vitamin A. Group: Enzymes. Synonyms: retinol saturase; RetSat; (13,14)-all-trans-retinol saturase; all-trans-retinol:all-trans-13,14-dihydroretinol saturase. Enzyme Commission Number: EC 1.3.99.23. CAS No. 879291-21-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1425; all-trans-retinol 13,14-reductase; EC 1.3.99.23; 879291-21-1; retinol saturase; RetSat; (13,14)-all-trans-retinol saturase; all-trans-retinol:all-trans-13,14-dihydroretinol saturase. Cat No: EXWM-1425. |  |
| CD1530 | CD1530 is a potent and selective retinoic acid receptor(RAR) agonist with Ki values of 150, 1500 and 2750 nM for RARγ, RARβ and RARα receptors respectively. It was also a potent CYP26A1 inhibitor as ketoconazole with an IC50 value of 530 nM. It inhibited excessive ROS production in tongue epithelial cells in vitro. It demonstrates transcriptional activity at RARγ with an AC50 value of 1.8 nM. It has been shown to preserve human tendon stem cell characteristics, promote repair of injured skeletal muscle, and in combination with bexarotene to inhibit oral carcinogenesis. Synonyms: 4-(6-Hydroxy-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl)benzoic acid; CD 1530; CD-1530; Benzoic acid, 4-(6-hydroxy-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl)-; 4-[7-(Adamantan-1-yl)-6-hydroxy-2-naphthyl]benzoic acid. Grades: ≥95%. CAS No. 107430-66-0. Molecular formula: C27H26O3. Mole weight: 398.49. | |
| dl-α-Tocopheryl Retinoate | dl-α-Tocopheryl Retinoate is an α-tocopherol ester of all-trans retinoic acid. Synonyms: Retinoic acid, (2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl ester, (±)-; (2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl (±)-retinoate; Retinoic acid, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl ester, [2R*(4R*,8R*)]-(±)-; L 300; N 021; Olcenon; Tocoretinate; Tretinoin tocoferil. Grades: 95%. CAS No. 40516-48-1. Molecular formula: C49H76O3. Mole weight: 713.12. | |
| HX 531 | HX 531 is a potent RXR antagonist (IC50 = 18 nM) that inhibits 9-cis retinoic acid-induced transactivation of RXR. HX 531 promotes the differentiation of white and brown pre-adipocyte to white adipocytes, and reduces triglyceride content in white adipose tissue, skeletal muscle, and the liver of mice given a high fat diet. Synonyms: HX 531; HX-531; HX531. 4-(7,8,9,10-Tetrahydro-5,7,7,10.10-pentamethyl-2-nitro-5H-benzo[b]naphtho[2,3-e][1,4]-diazepin-12-yl)-benzoic acid. Grades: ≥98% by HPLC. CAS No. 188844-34-0. Molecular formula: C29H29N3O4. Mole weight: 483.56. | |
| Inarigivir ammonium | Inarigivir (ORI-9020) ammonium is a dinucleotide antiviral drug that can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir (ORI-9020) ammonium acts as a RIG-I (Retinoic acid-inducible gene-I) agonist to activate cellular innate immune responses [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ORI-9020 ammonium; SB-9000 ammonium. CAS No. 2172788-92-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-101954A. |  |
| Liarozole hydrochloride | Liarozole is a benzimidazole derivative with potential antineoplastic activity. As a retinoic acid metabolism blocking agent (RAMBA), liarozole inhibits cytochrome P450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, resulting in an increase in endogenous ATRA production, inhibition of cell proliferation, and induction of cell differentiation. This agent also inhibits aromatase, the enzyme that catalyzes the final, rate-limiting step in estrogen biosynthesis. Synonyms: Liarozole HCl; R75251 (hydrochloride); 5-((3-chlorophenyl)(1H-imidazol-1-yl)methyl)-1H-benzo[d]imidazole hydrochloride. CAS No. 145858-50-0. Molecular formula: C17H14Cl2N4. Mole weight: 345.23. | |
| Melanoma antigen preferentially expressed in tumors (100-108) | Melanoma antigen preferentially expressed in tumors (100-108) is a bioactive peptide of Melanoma antigen preferentially expressed in tumors. Melanoma antigen preferentially expressed in tumors inhibits the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG as a transcriptional repressor. Synonyms: Opa-interacting protein 4 (100-108); Preferentially expressed antigen of melanoma (100-108). | |
| (±)-ML 209 | (±)-ML 209 (compound 4n), a diphenylpropanamide, is a retinoic acid-related orphan receptor RORγ antagonist with an IC 50 of 1.1 μM. (±)-ML 209 inhibits RORγt transcriptional activity with an IC 50 of 300 nM in HEK293t cells. (±)-ML 209 inhibits the transcriptional activity of RORγt, but not RORα in cells. (±)-ML 209 selectively inhibits murine Th17 cell differentiation without affecting the differentiation of naïve CD4 + T cells into other lineages, including Th1 and regulatory T cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1334526-14-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126037. | |
| Neuronal Differentiation Inducer (Isobavachin, 7-hydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)chroman-4-one) | A cell-permeable, 8-prenyl flavone that is shown to induce differentiation of mouse embryonic stem (ES) cells into neuronal cells and astrocytes, at 100nM. It is shown to elicit the down-regulation of p38 and JNK phosphorylation, and the up-regulation of ERK phosphorylation. Co-treatment with GGTI-298 (1000nM), a Geranyl geranyl transferase I Inhibitor selectively abolishes the IBA- but not Retinoic Acid-induced neuronal differentiation, which suggests that the differentiation inducing effect may involve protein prenylation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| PD-153035 | PD153035 is a ATP-competitive EGFR inhibitor with an IC50 and Ki of 25 and 6 pM. PD153035 effectively blocks the enhancement of mitogenesis, induction of early gene expression, and oncogenic transformation that occur in response to EGF receptor stimulation. With human fibroblasts and epidermoid carcinoma cells, PD153035 at nanomolar concentrations rapidly inhibits EGFR autophosphorylation. With breast and ovarian cancer cells, PD153035 not only blocks cell growth via inhibition of EGFR, but also upregulates the expression of the tumor suppressor retinoic acid receptor-beta 2 (RAR-beta2). Uses: Antineoplastic agents. Synonyms: AG 1517; AG1517; AG-1517; NSC 669364; NSC669364; NSC-669364; PD 153035; PD153035; SU 5271; SU5271; SU-5271; WHI-P 79. Grades: >98%. CAS No. 153436-54-5. Molecular formula: C16H14BrN3O2. Mole weight: 360.211. | |
| Peretinoin | Peretinoin, also known as NIK-333, orally available, acyclic retinoid with potential antineoplastic and chemopreventive activities. Peretinoin binds to and activates nuclear retinoic acid receptors (RAR), which in turn recruit coactivator proteins and promote, with other transcriptional complexes, the transcription of target genes. As a result, this agent may modulate the expression of genes involved in the regulation of cell proliferation, cell differentiation, and apoptosis of both normal and tumor cells. Synonyms: Peretinoin; NIK-333; NIK 333; NIK333. Grades: 99.79%. CAS No. 81485-25-8. Molecular formula: C20H30O2. Mole weight: 302.458. | |
| Peretinoin | Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1 [1]. Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression [2]. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC 50 of 9 μM [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NIK333. CAS No. 81485-25-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100008. | |
| rac all-trans 3-(Acetyloxy) Retinol Acetate | A metabolite of all-trans Retinoic acid. Group: Biochemicals. Alternative Names: 3-(Acetyloxy)-retinol Acetate. Grades: Highly Purified. CAS No. 76686-33-4. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| rac all-trans 3-(Acetyloxy) Retinol Acetate | rac all-trans 3-(Acetyloxy) Retinol Acetate is a metabolite of all-trans Retinoic acid. Retinoic Acid is a metabolite of Vitamin A and ajusts its functions of cellular growth and differentiation. Uses: A metabolite of all-trans retinoic acid. Synonyms: 3-(Acetyloxy)-retinol Acetate. Grades: ≥95%. CAS No. 76686-33-4. Molecular formula: C24H34O4. Mole weight: 386.52. | |
| Retinoic acid | Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC 50 s of 14 nM for RARα/β/&gamma. Retinoic acid bind to PPARβ/δ with K d of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha. Uses: Scientific research. Group: Natural products. Alternative Names: Vitamin A acid; all-trans-Retinoic acid; ATRA. CAS No. 302-79-4. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-14649. | |
| Retinoic Acid-Gambogic Acid Liposome | Retinoic acid is an intermediate product of vitamin A metabolism. Gambogic acid is derived from the gamboge and is a protease activator and apoptosis inducer. This product is a pre-formulated composite liposome with retinoic acid and gambogic acid. It can induce apoptosis in tumor cells and exerts synergistic anti-tumor effects. It is only for research purposes. Group: Drug-loaded liposome. Categories: liposomes, niosomes, ethosomes, and transfersomes. |  |
| Retinoic Acid-Glycyrrhizic Flavone Liposome | Retinoic acid is an intermediate product of vitamin A metabolism. Glycyrrhizic flavone are compounds extracted from licorice that have corticosteroid-like effects. This product is a pre-formulated composite liposome with retinoic acid and glycyrrhizic flavone. It can be used for epithelial cell abnormalities such as hyperpigmentation and photoaging. It is only for research purposes. Group: Drug-loaded liposome. Categories: liposomes, niosomes, ethosomes, and transfersomes. | |
| Retinoic Acid Liposome | Retinoic acid is an intermediate product of vitamin A metabolism, which can affect bone growth and promote metabolic effects such as epithelial cell proliferation, differentiation and keratolysis. This product is a pre-formulated liposome with vitamina acid. It is only for research purposes. Group: Drug-loaded liposome. Categories: liposomes, niosomes, ethosomes, and transfersomes. | |
| RORg Inverse Agonist, SR2211 (1,1,1,3,3,3-hexafluoro-2-(2-fluoro-4'-((4-(pyridin-4-ylmethyl)piperazin-1-yl)methyl)-[1,1'-biphenyl]-4-yl)propan-2-ol, SR-2211, SR 2211) | A cell-permeable, piperazine containing biphenyl compound that binds directly to retinoic acid receptor related orphan receptor g (RORg) and acts as a highly selective and inverse agonist (Ki =105nM; IC50 ~320nM). Reported to block the transcriptional activity of RORg and suppress the synthesis of IL-17 in EL-4 murine lymphoma cell line. Exhibits only a minimal effect on RORa and LXRa activity.CAS Number:1359164-11-6. Group: Biochemicals. Grades: Highly Purified. CAS No. 1359164-11-6. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| SR1001 | Retinoic-acid-receptor-related orphan receptors (ROR) α and γ play a key role in the development of T-helper cells that produce interleukin-17 (TH17 cells), a subset of CD4+ T-cells that contribute to the inflammatory process and have been implicated in the pathology of autoimmune diseases. SR 1001 is a synthetic ligand specific for RORα and RORγ (Kis = 172 and 111 nM, respectively) that functions as an inverse agonist at these receptors. SR 1001 has been shown to suppress IL-17 promoter driven transcriptional activity by inhibiting the interaction of co-activators such as TRAP220 nuclear receptor box 2 peptide (IC50 = 117 nM) and SRC2 with RORα and RORγ as well as by increasing the recruitment of corepressors such as NCoR. At 5 μM, SR 1001 inhibits TH17 cell differentiation and IL-17A secretion in cultured splenocytes and human PBMCs. A 25 mg/kg dose of SR 1001 twice/day delays the onset and the severity of experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis. Synonyms: SR 1001; SR-1001. Grades: >98%. CAS No. 1335106-03-0. Molecular formula: C15H13F6N3O4S2. Mole weight: 477.4. | |
| SR 11302 | SR 11302 is an inhibitor of activator protein-1 (AP-1), which is a transcription factor activity that displays antitumor effects in vivo. SR 11302 does not activate transcription from the retinoic acid response element (RARE) and displays no activity at retinoic acid receptors (EC50 > 1 μM for RARα, RARβ, RARγ and RXRα). Synonyms: SR 11302; SR11302; SR-11302; (E,E,Z,E)-3-Methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid; (2E,4E,6Z,8E)-3-methyl-7-(4-methylphenyl)-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid. Grades: ≥98% by HPLC. CAS No. 160162-42-5. Molecular formula: C26H32O2. Mole weight: 376.54. | |
| SR 2211 | SR 2211 is a selective inverse agonist of retinoic acid receptor-related orphan receptor γ (RORγ) (Ki = 105 nM; IC50 ~320 nM). SR 2211 exhibits weak activity at liver X receptor α (LXRα) and has no effect on transcriptional activity of farnesoid X receptors (FXR) or transcriptional activity of ROR&alpha. Synonyms: SR-2211; SR2211;SR 2211; 2-Fluoro-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-a,a-bis(trifluoromethyl)-[1,1'-biphenyl]-4-methanol; 1,1,1,3,3,3-hexafluoro-2-[3-fluoro-4-[4-[[4-(pyridin-4-ylmethyl)piperazin-1-yl]methyl]phenyl]phenyl]propan-2-ol. Grades: ≥98% by HPLC. CAS No. 1359164-11-6. Molecular formula: C26H24F7N3O. Mole weight: 527.48. | |
| SR3335 | The retinoic acid receptor-related receptors (RORs) are orphan nuclear receptors with diverse putative roles. SR 3335 is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki = 220 nM) and inhibiting constitutive transactivation activity (IC50 = 480 nM). It has no effect on RORβ, RORγ, farnesoid X receptor, or liver X receptor &alpha. SR 3335 evokes RORα-dependent effects both in vitro and in vivo, altering gene expression as well as gluconeogenesis. Synonyms: ML-176; SR 3335; SR-3335; ML176; ML 176. Grades: >98%. CAS No. 293753-05-6. Molecular formula: C13H9F6NO3S2. Mole weight: 405.34. | |
| Talarozole | Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA) which increases intracellular levels of endogenous all-trans retinoic acid (RA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC 50 s of 5.4 and 0.46 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R115866. CAS No. 201410-53-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14531. | |
| Tamibarotene | Tamibarotene is a retinoic acid receptor α (RARα) agonist that induces differentiation and apoptosis of HL-60 cells in vitro. It exhibits antiproliferative effects against a variety of human tumor cells lines and displays anticancer activity against acute promyelocytic leukemia in vivo. It is an orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity. It may show sustained plasma levels compared to ATRA. It may exhibit a lower toxicity profile than ATRA, in part, due to the lack of affinity for the RAR-gamma receptor, the major retinoic acid receptor in the dermal epithelium. Synonyms: Retinobenzoic acid; Amnoid; AMNOLAKE; Am80; Am 80; Am-80; SY-1425; SY 1425; SY1425; Tamibarotene. Grades: 98%. CAS No. 94497-51-5. Molecular formula: C22H25NO3. Mole weight: 351.44. | |
| THPN | THPN is a potent Nur77 agonist. THPN specifically binds the LBD of Nur77 (TR3) but not that of retinoic acid receptor α and PPARγ with a K d of 270 nM. THPN leads to Nur77 translocation to the mitochondria to induce autophagic cell death in melanoma [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 100079-26-3. Pack Sizes: 5 mg. Product ID: HY-113827. | |
| Tretinoin | Tretinoin, a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells. Synonyms: (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid; All-trans Retinoic Acid; Isotretinoin EP Impurity A. Grades: 98%. CAS No. 302-79-4. Molecular formula: C20H28O2. Mole weight: 300.43. | |
| 13-cis-Retinonitrile-13C2 | An isomer of a labeled all-trans-Retinal intermediate. Group: Biochemicals. Alternative Names: (2E,4E,6E,8Z)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenenitrile-13C2. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 3-Dehydro Retinol | Naturally occurring retinoid originally discovered in livers of freshwater fish. Constitutes 20-25% of total retinoid content in human epidermis; levels are markedly elevated in patients with hyperproliferative dermatoses such as psoriasis. Group: Biochemicals. Alternative Names: (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1,3-cyclohexadien-1-yl)-2,4,6,8-nonatetraen-1-ol; 3,4-Dehydroretinol;all-trans- 3-Dehydroretinol; Dehydroretinol; Vitamin A2; all-trans-3,4-Didehydroretinol. Grades: Highly Purified. CAS No. 79-80-1. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| A 1120 | A 1120 is a retinol-binding protein 4 (RBP4) antagonist (Ki = 8.3 nM) that can reduce serum RBP4 and retinol, and displaces transthyretin (TTR) from RBP4-TTR complexes. Synonyms: A-1120; A1120; 2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid. Grades: ≥99% by HPLC. CAS No. 1152782-19-8. Molecular formula: C20H19F3N2O3. Mole weight: 392.37. | |
| Adapalene Elastic Liposome | Adapalene (ADA) is a synthetic retinoid that belongs to the class of topical anti-acne drugs. It regulates the differentiation of keratinocyte cells, promotes keratin dissolution, and has anti-inflammatory and anti-seborrheic effects. However, it can cause irritation and photosensitivity. This product is a pre-formulated liposome encapsulating Adapalene. This product uses Tween-80 to increase elasticity, facilitating easier drug penetration through the skin. It is only for research purposes. Group: Drug-loaded liposome. Categories: Niosomes, ethosomes, and transfersomes. | |
| Adapalene Flexible Liposome | Adapalene (ADA) is a synthetic retinoid that belongs to the class of topical anti-acne drugs. It regulates the differentiation of keratinocyte cells, promotes keratin dissolution, and has anti-inflammatory and anti-seborrheic effects. However, it can cause irritation and photosensitivity. This product is a pre-formulated liposome encapsulating Adapalene. This product is formulated with propylene glycol to enhance its deformability, making the drug more permeable through the skin. It is only for research purposes. Group: Drug-loaded liposome. Categories: Niosomes, ethosomes, and transfersomes. | |
| Adapalene Liposome | Adapalene (ADA) is a synthetic retinoid that belongs to the class of topical anti-acne drugs. It regulates the differentiation of keratinocyte cells, promotes keratin dissolution, and has anti-inflammatory and anti-seborrheic effects. However, it can cause irritation and photosensitivity. This product is a pre-formulated liposome encapsulating Adapalene. It is only for research purposes. Group: Drug-loaded liposome. Categories: Niosomes, ethosomes, and transfersomes. | |
| Adapalene Thermosensitive Liposome | Adapalene (ADA) is a synthetic retinoid that belongs to the class of topical anti-acne drugs. It regulates the differentiation of keratinocyte cells, promotes keratin dissolution, and has anti-inflammatory and anti-seborrheic effects. However, it can cause irritation and photosensitivity. This product is a pre-formulated liposome encapsulating Adapalene. This product incorporates DPPC, which releases the drug at temperatures ranging from 39 to 42°C. It is only for research purposes. Group: Drug-loaded liposome. Categories: Niosomes, ethosomes, and transfersomes. | |
| All-trans-13,14-dihdyro retinol | Heterocyclic Organic Compound. Alternative Names: 13,14-Dihydro-all-trans-retinol; 13,14-Dihydroretinol. CAS No. 115797-14-3. Molecular formula: C20H32O. Mole weight: 288.47. Catalog: ACM115797143. |  |
| all-trans Acitretin-d3 ((all-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic Acid-d3, Neotigason-d3, Soriatane-d3) | A synthetic retinoid which is the major metabolite of etretinate. Group: Biochemicals. Alternative Names: (all-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic Acid-d3; Neotigason-d3; Soriatane-d3. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| all-trans-Anhydro retinol | all-trans-Anhydro retinol. Group: Biochemicals. Alternative Names: (6E)-6-[(2E,4E,6E)-3,7-Dimethyl-2,4,6,8-nonatetraen-1-ylidene]-1,5,5-trimethylcyclohexene. Grades: Highly Purified. CAS No. 1224-78-8. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C20H28. US Biological Life Sciences. | Worldwide |
| All-Trans-Anhydro Retinol | Heterocyclic Organic Compound. Alternative Names: (6E)-. CAS No. 1224-78-8. Molecular formula: C20H28. Mole weight: 268.44. Purity: 0.96. IUPACName: (6E)-6-[(2E,4E,6E)-3,7-dimethylnona-2,4,6,8-tetraenylidene]-1,5,5-trimethylcyclohexene. Density: 0.902g/cm³. Catalog: ACM1224788. | |
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