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(1R) -1- [ [3-(trifluoromethyl ) phenyl ] methyl ]-2-oxo-2- (1-pyrrolidinyl ) ethyl ] 1, 2, 3, 4-tetra hydro-6-isoquinolinesulfonamid e Hydrochloride known as (-)-PFI-2 HCl is a cell permeable inhibitor of SET Domain-Containing protein 7/9 (SET 7/9) which plays a role in tumorigenesis in cell cancer lines. Group: Biochemicals. Grades: Highly Purified. CAS No. 1627607-87-7. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C23H25F4N3O3S; x(HCl). US Biological Life Sciences.
2-[(1S)-1-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-2-(4-fluorophenyl)-2-oxoethoxy]acetic Acid Methyl Ester is an intermediate in the preparation of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Uses: Intermediate in the preparation of aprepitant metabolites. Synonyms: Methyl [(1S)-1-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-2-(4-fluorophenyl)-2-oxoethoxy]acetate; [(1S)-1-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-2-(4-fluorophenyl)-2-oxoethoxy]acetic Acid Methyl Ester; Acetic acid, 2-[(1S)-1-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-2-(4-fluorophenyl)-2-oxoethoxy]-, methyl ester. Grades: ≥95%. CAS No. 419574-29-1. Molecular formula: C21H17F7O5. Mole weight: 482.34.
(2R) -3-Bromo-2-hydroxy-2-methyl-N-[4-nitro-3- (trifluoromethyl) phenyl]propanamide is an intermediate in the synthesis of 4-Desacetamido-4-fluoro Andarine (D289530), a Selective Androgen Receptor Modulator (SARM) that has potential use for treatment of androgen related diseases such as muscle wasting and osteoporosis. Group: Biochemicals. Grades: Highly Purified. CAS No. 206193-18-2. Pack Sizes: 5mg, 10mg. Molecular Formula: C11H10BrF3N2O4. US Biological Life Sciences.
(4R) -3-[ (2S, 5R) -5- (4-Fluorophenyl) -2-[ (R) -[ (4-fluorophenyl) amino][4-[ (trimethylsilyl) oxy]phenyl]methyl]-1-oxo-5-[ (trimethylsilyl) oxy]pentyl]-4-phenyl-2-oxazolidinone is an intermediate in the preparation of Ezetimibe (E975000). Group: Biochemicals. Grades: Highly Purified. CAS No. 272778-12-8. Pack Sizes: 25mg. US Biological Life Sciences.
Used as an antiandrogen, antineoplastic (hormonal). Group: Biochemicals. Alternative Names: ICI-176334-d4; Casodex-d4; N-[4-Cyano-3-trifluoromethyl) phenyl]- 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide-d4. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
A small molecule agonist of the human Peroxisome Proliferator-Activated Recept d (PPAR d). It shows an EC50 of 1.1 nM against PPAR d with 100-fold selectivity over the other human subtypes. Group: Biochemicals. Alternative Names: 4-[[[2-[3-Fluoro-4- (trifluoromethyl) phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy] Acetic Acid. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Cell-permeable. A potent antagonist of the Hedgehog (Hh) signaling pathway (IC50 = 70nM). Group: Biochemicals. Grades: Highly Purified. CAS No. 330796-24-2. Pack Sizes: 1mg. US Biological Life Sciences.
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L-Phenylalanine 7-amido-4-methylcoumarin trifluoroacetate salt
L-Phenylalanine 7-Amido-4-methylcoumarin, Trifluoroacetate Salt is a fluorogenic substrate for phenylalanine peptidase yielding a blue fluorescent solution from cleavage. L-Phenylalanine 7-Amido-4-methylcoumarin, Trifluoroacetate Salt can be used as reactant/reagent for activation of lymphocyte progranzyme by dipeptidyl peptidase I. Synonyms: (S)-2-Amino-N-(4-Methyl-2-Oxo-2H-Chromen-7-Yl)-3-Phenylpropanamide 2,2,2-Trifluoroacetate; L-Phenylalanine-AMC TFA salt. Grades: ≥ 98% (HPLC). CAS No. 108321-84-2. Molecular formula: C21H19F3N2O5. Mole weight: 436.38.
A potent modulator of Hedgehog (Hh) protein function; a nanomolar Hh antagonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 330796-24-2. Pack Sizes: 1mg. US Biological Life Sciences.
An orally bioavailable oxindole compound that and acts as a potent, reversible and type II DFG-out inhibitor of pan-Trk activity (IC50=8 and 12nM for TrkA and TrkB). Shown to target Trk (tropomyosin receptor kinase) ATP binding cleft and an immediately adjacent hydrophobic pocket. Preferentially arrests the proliferation of Ba/F3 cells fused with Tel-TrkA, Tel-TrkB and Tel-TrkC (IC50=11, 9 and 7nM, respectively) and in Ba/F3 and RIE cells expressing both TrkA and NGF (IC50=42 and 17nM, respectively) over Mo7e-c-Kit and Rat-A10-PDGFR (IC50=1 and 0.5uM) and Ba/F3-Tel-R and wt-Ba/F3 cells (IC50=3.0 and 5.6uM). Displays ~100-fold greater selectivity among a panel of 59 closely related kinases and in 33 cellular kinase assays. Weakly active against relevant cytochrome P450 isozymes and hERG channel, and exhibit adequate microsomal stability, pharmacokinetic profile and efficacy in mice and rats. Suppresses tumor growth in a mouse RIE-TrkAmNGF xenograft model (50mg/kg, p.o.). Group: Biochemicals. Grades: Highly Purified. CAS No. 1033769-28-6. Pack Sizes: 10mg. US Biological Life Sciences.
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(1R,2R,3R)-Aprepitant
An isomer of Aprepitant, a medication used to prevent chemotherapy-induced nausea and vomiting (CINV) and to prevent postoperative nausea and vomiting. Synonyms: 5-[[(2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one. Grades: > 95%. CAS No. 1148113-53-4. Molecular formula: C23H21F7N4O3. Mole weight: 534.44.
(1'R,2R,3R)-Fosaprepitant Dimeglumine
(1'R,2R,3R)-Fosaprepitant Dimeglumine is an isomer of Fosaprepitant, which is a selective neurokinin-1 (NK-1) receptor antagonist used as an antiemetic drug. Synonyms: (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentaol (3-(((2R,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid (2:1); [3-[[(2R,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-5-oxo-4H-1,2,4-triazol-1-yl]phosphonic acid (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol (1:2). Molecular formula: C37H56F7N6O16P. Mole weight: 1004.83.
(1R,2S,3R)-Aprepitant
An isomer of Aprepitant, a medication used to prevent chemotherapy-induced nausea and vomiting (CINV) and to prevent postoperative nausea and vomiting. Synonyms: 5-(((2S,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one. Grades: > 95%. CAS No. 1185502-97-9. Molecular formula: C23H21F7N4O3. Mole weight: 534.44.
(1'R,2S,3R)-Fosaprepitant Dimeglumine
(1'R,2S,3R)-Fosaprepitant Dimeglumine is an isomer of Fosaprepitant, which is a selective neurokinin-1 (NK-1) receptor antagonist used as an antiemetic drug. Uses: Antiemetics. Synonyms: (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentaol (3-(((2S,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid (2:1); [3-[[(2S,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-5-oxo-4H-1,2,4-triazol-1-yl]phosphonic acid (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol (1:2). Molecular formula: C37H56F7N6O16P. Mole weight: 1004.83.
(1R,2S,3S)-Aprepitant
An isomer of Aprepitant, a medication used to prevent chemotherapy-induced nausea and vomiting (CINV) and to prevent postoperative nausea and vomiting. Synonyms: 5-(((2S,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one. Grades: > 95%. CAS No. 172822-28-5. Molecular formula: C23H21F7N4O3. Mole weight: 534.44.
(1'R,2S,3S)-Fosaprepitant Dimeglumine
(1'R,2S,3S)-Fosaprepitant Dimeglumine is an isomer of Fosaprepitant, which is a selective neurokinin-1 (NK-1) receptor antagonist used as an antiemetic drug. Synonyms: (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentaol (3-(((2S,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid (2:1); [3-[[(2S,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-5-oxo-4H-1,2,4-triazol-1-yl]phosphonic acid (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol (1:2). Molecular formula: C37H56F7N6O16P. Mole weight: 1004.83.
(1S,2R,3R)-Aprepitant
An isomer of Aprepitant, a medication used to prevent chemotherapy-induced nausea and vomiting (CINV) and to prevent postoperative nausea and vomiting. Synonyms: 5-(((2R,3R)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one. Grades: > 95%. CAS No. 1242175-34-3. Molecular formula: C23H21F7N4O3. Mole weight: 534.44.
(1'S,2R,3R)-Fosaprepitant Dimeglumine
(1'S,2R,3R)-Fosaprepitant Dimeglumine is an isomer of Fosaprepitant, which is a selective neurokinin-1 (NK-1) receptor antagonist used as an antiemetic drug. Synonyms: (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentaol (3-(((2R,3R)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid (2:1); [3-[[(2R,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-5-oxo-4H-1,2,4-triazol-1-yl]phosphonic acid (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol (1:2). Molecular formula: C37H56F7N6O16P. Mole weight: 1004.83.
(1'S,2R,3S)-Fosaprepitant Dimeglumine
(1'S,2R,3S)-Fosaprepitant Dimeglumine is an isomer of Fosaprepitant, which is a selective neurokinin-1 (NK-1) receptor antagonist used as an antiemetic drug. Synonyms: (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentaol (3-(((2R,3S)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid (2:1); [3-[[(2R,3S)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-5-oxo-4H-1,2,4-triazol-1-yl]phosphonic acid (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol (1:2). Molecular formula: C37H56F7N6O16P. Mole weight: 1004.83.
(1'S,2S,3R)-Fosaprepitant Dimeglumine
(1'S,2S,3R)-Fosaprepitant Dimeglumine is an isomer of Fosaprepitant, which is a selective neurokinin-1 (NK-1) receptor antagonist used as an antiemetic drug. Synonyms: (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentaol (3-(((2S,3R)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid (2:1); [3-[[(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-5-oxo-4H-1,2,4-triazol-1-yl]phosphonic acid (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol (1:2). Molecular formula: C37H56F7N6O16P. Mole weight: 1004.83.
(1S,2S,3S)-Aprepitant
An isomer of Aprepitant, a medication used to prevent chemotherapy-induced nausea and vomiting (CINV) and to prevent postoperative nausea and vomiting. Synonyms: 5-(((2S,3S)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one. Grades: > 95%. CAS No. 1242175-40-1. Molecular formula: C23H21F7N4O3. Mole weight: 534.44.
(1'S,2S,3S)-Fosaprepitant Dimeglumine
(1'S,2S,3S)-Fosaprepitant Dimeglumine is an isomer of Fosaprepitant, which is a selective neurokinin-1 (NK-1) receptor antagonist used as an antiemetic drug. Synonyms: (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentaol (3-(((2S,3S)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid (2:1); [3-[[(2S,3S)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-5-oxo-4H-1,2,4-triazol-1-yl]phosphonic acid (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol (1:2). Molecular formula: C37H56F7N6O16P. Mole weight: 1004.83.
2,3,4,6-Tetra-O-benzyl-a-D-glucopyranosyl fluoride, a paramount compound in the field of biomedicine, holds immense significance. It is extensively utilized in the amalgamation of diverse medications aimed at combating afflictions like diabetes, cancer, and cardiovascular maladies. This pivotal product serves as a catalyst in the progression of innovative pharmaceuticals, characterized by augmented therapeutic efficacy. Synonyms: 2,3,4,6-Tetra-O-benzyl-alpha-D-glucopyranosyl Fluoride; (2R,3R,4S,5R,6R)-3,4,5-Tris(benzyloxy)-2-((benzyloxy)methyl)-6-fluorotetrahydro-2H-pyran; (2R,3R,4S,5R,6R)-2-fluoro-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxane; 2,3,4,6-Tetra-O-benzyl-|A-D-glucopyranosyl Fluoride; 2,3,4,6-Tetra-O-benzyl-a-D-glucopyranosyl fluoride; SCHEMBL2124878; DTXSID40454866; MFCD03701104; AKOS015888992; HY-W145636; AS-74271; CS-0226064; T1922; T73043; 2,3,4,6-Tetra-O-benzyl- alpha -D-glucopyranosyl Fluoride; (2R,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-2-(benzyloxymethyl)-6-fluorotetrahydro-2H-pyran; (2R,3R,4S,5R,6R)-3,4,5-TRIS(BENZYLOXY)-2-[(BENZYLOXY)METHYL]-6-FLUOROOXANE. CAS No. 89025-46-7. Molecular formula: C34H35FO5. Mole weight: 542.64.
2,3,4,6-Tetra-O-benzyl-b-D-glucopyranosyl Fluoride, a glucose derivative incorporating fluorine, functions as a glycosylation agent for synthesizing convoluted carbohydrates of paramount significance. Additionally, this compound finds extensive application in the manufacture of glycopeptides that deliver therapeutic interventions for fatal ailments, cancer and HIV/AIDS, among others. Synonyms: 2,3,4,6-Tetra-O-benzyl-beta-D-glucopyranosyl Fluoride; 2,3,4,6-tetra-o-benzyl-beta-d-glucopyranosylfluoride; (2R,3R,4S,5R,6S)-3,4,5-Tris(benzyloxy)-2-((benzyloxy)methyl)-6-fluorotetrahydro-2H-pyran; (2S,3R,4S,5R,6R)-2-fluoro-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxane; MFCD01862264; 2,3,4,6-Tetra-O-benzyl-|A-D-glucopyranosyl Fluoride; SCHEMBL7155426; DTXSID10447063; HY-W145623; CS-0226050; T1923; D92545; J-004847; 2,3,4,6-Tetra-O-benzyl-?-D-glucopyranosyl fluoride; 2,3,4,6-Tetra-O-benzyl-|A-D-glucopyranosylfluoride. CAS No. 78153-79-4. Molecular formula: C34H35FO5. Mole weight: 542.64.
2,3,4,6-Tetra-O-benzyl-D-glucopyranosyl fluoride
2,3,4,6-Tetra-O-benzyl-D-glucopyranosyl fluoride, an indispensable reagent in the biomedical domain, plays a pivotal role. Its usage primarily revolves around synthesizing diverse glycosidic compounds, particularly in the realm of potential drug development addressing diseases associated with anomalous carbohydrate metabolism. Synonyms: 2,3,4,6-Tetra-O-benzyl-D-glucopyranosyl Fluoride; D-Glucopyranosyl fluoride, 2,3,4,6-tetrakis-O-(phenylmethyl)-; (3R,4S,5R,6R)-2-fluoro-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxane; SCHEMBL2124872; DTXSID40449454; QNXIKNZDQVSBCO-BKJHVTENSA-N; AKOS037646847; HY-W145533; AS-71162; CS-0214498; T1971; E78804; A891021; 2,3,4,6-tetra-O-benzyl-alpha/beta-D-glucopyranosyl fluoride; (2R,3R,4S,5R)-3,4,5-TRIS(BENZYLOXY)-2-[(BENZYLOXY)METHYL]-6-FLUOROOXANE. CAS No. 122741-44-0. Molecular formula: C34H35FO5. Mole weight: 542.64.
2-(4-Fluorophenyl)-δ-hydroxy-5-(1-methylethyl)- β -oxo-3-phenyl-4-[ (phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid is an intermediate useful in the synthesis of rac-3-Oxo Atorvastatin Sodium Salt (O847150), which is a byproduct impurity of Atorvastatin Calcium (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglyceinhibitorrides in patients with hypercholesterolemia. Group: Biochemicals. Grades: Highly Purified. CAS No. 1391194-36-7. Pack Sizes: 500ug, 1mg. Molecular Formula: C33H33FN2O5, Molecular Weight: 556.62. US Biological Life Sciences.
2-(4-Fluorophenyl)-δ-hydroxy-5-(1-methylethyl)- β -oxo-3-phenyl-4-[ (phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid 1,1-Dimethylethyl Ester is an intermediate used in the synthesis of rac-3-Oxo Atorvastatin Sodium Salt (O847150), which is a byproduct impurity of Atorvastatin Calcium (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglyceinhibitorrides in patients with hypercholesterolemia. Group: Biochemicals. Grades: Highly Purified. CAS No. 947262-20-6. Pack Sizes: 500ug, 1mg. Molecular Formula: C37H41FN2O5, Molecular Weight: 612.73. US Biological Life Sciences.
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2-Fluoro-4-Desfluoro Bicalutamide
Synonyms: N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(2-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide; Bicalutamide EP Impurity B. Grades: > 95%. CAS No. 1159977-36-2. Molecular formula: C18H14F4N2O4S. Mole weight: 430.38.
3-Des-(4-fluorophenyl) 3-(4-Fluorobiphen-3-yl) is a derivative of Aprepitant, which is a novel selective neurokinin-1 (NK-1) receptor antagonist. Synonyms: 5-{[(2R,3S)-2-{(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy}-3-(3-fluoro-4-biphenylyl)-4-morpholinyl]methyl}-2,4-dihydro-3H-1,2,4-triazol-3-one; 3H-1,2,4-Triazol-3-one, 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(3-fluoro[1,1'-biphenyl]-4-yl)-4-morpholinyl]methyl]-2,4-dihydro-. Molecular formula: C29H25F7N4O3. Mole weight: 610.52.
3-Fluoro-4-desfluoro Bicalutamide
3-Fluoro-4-desfluoro Bicalutamide. Group: Biochemicals. Alternative Names: N-[4-Cyano-3-trifluoromethyl) phenyl]-3-[ (3-fluorophenyl) sulfonyl]-2-hydroxy-2-methylpropanamide. Grades: Highly Purified. CAS No. 1166228-30-3. Pack Sizes: 2.5mg. Molecular Formula: C18H14F4N2O4S, Molecular Weight: 430.37. US Biological Life Sciences.
Intermediate in the preparation of Phase-II metabolites of Ezetimibe. Glucuronide azetidinone cholesterol absorption inhibitor. Group: Biochemicals. Alternative Names: 4-[(2S,3R)-3-[(3S)-3-(Acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-oxo-2-azetidinyl]phenyl β-D-Glucopyranosiduronic Acid Methyl Ester 2,3,4-Triacetate. Grades: Highly Purified. CAS No. 190448-56-7. Pack Sizes: 1mg. US Biological Life Sciences.
Labeled intermediate in the preparation of Phase-II metabolites of Ezetimibe. Glucuronide azetidinone cholesterol absorption inhibitor. Group: Biochemicals. Alternative Names: 4-[(2S,3R)-3-[(3S)-3-(Acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl-d4)-4-oxo-2-azetidinyl]phenyl β-D-Glucopyranosiduronic Acid Methyl Ester 2,3,4-Triacetate. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
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(3S,5S)-Atorvastatin Sodium Salt
A selective, competitive HMG-CoA reductase inhibitor. The only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia. Group: Biochemicals. Alternative Names: ( βS,δS)-2-(4-Fluorophenyl)- β , δ -dihydroxy-5- (1-methylethyl)-3-phenyl-4-[ (phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid Sodium; 3S,5S-Atorvastatin Sodium. Grades: Highly Purified. CAS No. 501121-34-2. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C33H34FN2NaO5, Molecular Weight: 580.62. US Biological Life Sciences.
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4-Fluoro-2- (trifluoromethyl) benzenemethanamine
4-Fluoro-2- (trifluoromethyl) benzenemethanamine. Group: Biochemicals. Alternative Names: [4-Fluoro-2- (trifluoromethyl) benzyl]amine; [[4-Fluoro-2- (trifluoromethyl) phenyl]methyl]amine. Grades: Highly Purified. CAS No. 202522-22-3. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C8H7F4N. US Biological Life Sciences.
An Atorvastatin intermediate. Atorvastatin is a selective, competitive HMG-CoA reductase inhibitor. The only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia. Group: Biochemicals. Alternative Names: 2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic Acid Phenylamide. Grades: Highly Purified. CAS No. 125971-96-2. Pack Sizes: 1g. US Biological Life Sciences.
An deuterated intermediate of deuterated Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. The only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia. Group: Biochemicals. Alternative Names: 2-[2-(4-Fluorophenyl)-2-oxo-1-phenyl-d5-ethyl]-4-methyl-3-oxopentanoic Acid Phenylamide. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
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4-Hydroxy Atorvastatin Calcium Salt
4-Hydroxyatorvastatin is a hydroxylated metabolite of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia. Group: Biochemicals. Alternative Names: ( βR,δR)-2-(4-Fluorophenyl)- β , δ -dihydroxy-4-[[ (4-hydroxyphenyl) amino]carbonyl]-5- (1-methylethyl) -3-phenyl-1H-pyrrole-1-heptanoic Acid Calcium Salt; p-Hydroxyatorvastatin. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
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AMG 333
AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM for hTRPM8 and IC50 of 20 nM for rTRPM8, which displays high selectivity over other TRP channels (IC50>20 uM, TRPV1/V3/V4/A1). AMG-333 was well-tolerated in 28 day rat and dog preclinical safety studies and advanced to Phase 1 human clinical trials. Synonyms: 6-[[[ (S) - (3-Fluoro-2-pyridinyl) [3-fluoro-4- (trifluoromethoxy) phenyl]methyl]amino]carbonyl]-3-pyridinecarboxylic acid. Grades: ≥98% by HPLC. CAS No. 1416799-28-4. Molecular formula: C20H12F5N3O4. Mole weight: 453.33.
Apalutamide Impurity 15. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-cyano-5-(5-(3-fluoro-4-(methylcarbamoyl)phenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)pyridine 1-oxide. Molecular Formula: C21H15F4N5O3S. Mole Weight: 493.08. Catalog: APB02985.
Apalutamide Impurity 17
Apalutamide Impurity 17. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 5-(5-(3-fluoro-4-(methylcarbamoyl)phenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinic acid. Molecular Formula: C21H16F4N4O4S. Mole Weight: 496.08. Catalog: APB02984.
Apalutamide Impurity 2
Apalutamide Impurity 2. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 5-(5-(3-fluoro-4-(methylcarbamoyl)phenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinamide. Molecular Formula: C21H17F4N5O3S. Mole Weight: 495.45. Catalog: APB02204.
Apalutamide Impurity 33
Apalutamide Impurity 33. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: methyl 1- (3- (6-cyano-5- (trifluoromethyl) pyridin-3-yl) -1- (3-fluoro-4- (methylcarbamoyl) phenyl) thioureido) cyclobutanecarboxylate. Molecular Formula: C22H19F4N5O3S. Mole Weight: 509.11. Catalog: APB02973.
Apalutamide Impurity 35
Apalutamide Impurity 35. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-((1-((6-cyano-5-(trifluoromethyl)pyridin-3-yl)carbamoyl)cyclobutyl)amino)-2-fluoro-N-(3-fluoro-4-(methylcarbamoyl)phenyl)-N-methylbenzamide. Molecular Formula: C28H23F5N6O3. Mole Weight: 586.18. Catalog: APB02972.
Apalutamide Impurity 4
Apalutamide Impurity 4. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-(3-fluoro-4-(methylcarbamoyl)phenyl)-N-methylbenzamide. Molecular Formula: C29H21F5N6O3S. Mole Weight: 628.57. Catalog: APB02990.
Apalutamide Impurity 5
Apalutamide Impurity 5. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-N-(1-((6-cyano-5-(trifluoromethyl)pyridin-3-yl)carbamoyl)cyclobutyl)-2-fluoro-N-(3-fluoro-4-(methylcarbamoyl)phenyl)benzamide. Molecular Formula: C40H27F8N9O4S. Mole Weight: 881.75. Catalog: APB02989.
Apalutamide Impurity 6
Apalutamide Impurity 6. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: O-phenyl (4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoyl)(methyl)carbamothioate. Molecular Formula: C28H19F4N5O3S2. Mole Weight: 613.61. Catalog: APB01817.
Aprepitant
Aprepitant an antiemetic and antagonist of the neurokinin-1 (NK1) receptor (Ki = 3nM; IC50 = 0.09nM for the human receptor).It is selective for NK1 over NK3 receptors (Ki = 454.1nM for human NK3). In vivo, aprepitant (1mg/Kg) prevents plasma extravasation into the esophagus of guinea pigs induced by substance P. It also reduces NK1-agonist-induced foot tapping in gerbils. Formulations containing aprepitant have been used to prevent chemotherapy-induced nausea and vomiting. Group: Biochemicals. Alternative Names: 5-[[ (2R, 3S) -2-[ (1R) -1-[3, 5-Bis (trifluoromethyl) phenyl]ethoxy]-3- (4-fluorophenyl) -4-morpholinyl]methyl]-1, 2-dihydro-3H-1, 2, 4-triazol-3-one; Emend; L 754030; MK-869; ONO-7436. Grades: Highly Purified. CAS No. 170729-80-3. Pack Sizes: 250mg, 500mg, 1g. Molecular Formula: C23H21F7N4O3, Molecular Weight: 534.43. US Biological Life Sciences.
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