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| Product | Description | |
|---|---|---|
| 10-Deacetyl Paclitaxel Propyl Analogue | An impurity of Paclitaxel which induces the expression of the gene for tumor necrosis factor &alpha. Synonyms: (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-(((2R,3S)-3-butyramido-2-hydroxy-3-phenylpropanoyl)oxy)-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl Benzoate; 10-Deacetyl-3'-debenzoyl-3'-butanoylpaclitaxel. Grades: > 95%. CAS No. 173101-47-8. Molecular formula: C42H51NO13. Mole weight: 777.87. |  |
| 11-?Keto-?beta-?boswellic acid | 11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 11-Keto-β-boswellic acid. CAS No. 17019-92-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N2056. |  |
| 1,2-dioleoyl-3-trimethylammonium-propane (chloride salt) | 1,2-dioleoyloxy-3-(trimethylammonium)propane (DOTAP) chloride has been used for the preparation of cationic liposome and liposome-DNA complex. It has also been used to assess tumor necrosis factor α (TNF-α) production. Synonyms: Dotap chloride; DOTAP-Cl; DOTAP (chloride); 1-Propanaminium, N,N,N-trimethyl-2,3-bis[[(9Z)-1-oxo-9-octadecenyl]oxy]-, chloride (1:1); 1,2-Dioleoyl-3-trimethylammonium-propane, Chloride; (+/-)-Dotap chloride; Dotap chloride, (+/-)-; N-(1-(2,3-Dioleoyloxy)propyl)-N,N,N-trimethylammonium chloride; (2,3-dioleoyloxy-propyl)-trimethylammonium-chloride; 18:1 TAP (DOTAP), 1,2-dioleoyl-3-trimethylammonium-propane (chloride salt), chloroform; DOTAP Chloride; N,N,N-Trimethyl-2,3-bis[[(9Z)-1-oxo-9-octadecenyl]oxy]-1-propanaminium; 2,3-di(octadec-9-enoyloxy)propyl-trimethylazanium. Grades: >98% by HPLC. CAS No. 132172-61-3. Molecular formula: C42H80ClNO4. Mole weight: 698.54. | |
| 2,3-Naphthalic Anhydride | 2,3-Naphthalic anhydride is used as a reagent to synthesize analogues of Thalidomide (T338850), an inhibitor of tumor necrosis factor that was once abandoned because it caused birth defects, but is currently used as an inhibitor of angiogenesis in patients with multiple myeloma. Group: Biochemicals. Grades: Highly Purified. CAS No. 716-39-2. Pack Sizes: 100mg, 1g. Molecular Formula: C12H6O3. US Biological Life Sciences. |  Worldwide |
| 2,6-Difluorophenol | 2,6-Difluorophenol is a bioisosteric analog of γ-Aminobutyric Acid (GABA). It can also be used to prepare isoxazolone (I918120) based inhibitors of tumor necrosis factor-alpha (TNF-α). Group: Biochemicals. Grades: Highly Purified. CAS No. 28177-48-2. Pack Sizes: 2.5g, 10g. Molecular Formula: C6H4F2O, Molecular Weight: 130.09. US Biological Life Sciences. | Worldwide |
| 2-Amino-N-methylacetamide Hydrochloride | 2-Amino-N-methylacetamide is an intermediate used to prepare macrocyclic hydroxamic acids that inhibit tumor necrosis factor α. It is also used to synthesize 2-[ (arylalkyl) amino]alkanamide derivatives with anticonvulsant activities. Group: Biochemicals. Grades: Highly Purified. CAS No. 49755-94-4. Pack Sizes: 1g, 5g. Molecular Formula: C3H9ClN2O, Molecular Weight: 124.57. US Biological Life Sciences. | Worldwide |
| 2-Thiomethylpyrimidine-4-carboxylic Acid | 2-Thiomethylpyrimidine-4-carboxylic Acid was a useful reagent in development of orally bioavailable bicyclic pyrazolones as inhibitors of tumor necrosis factor. Group: Biochemicals. Grades: Highly Purified. CAS No. 1126-44-9. Pack Sizes: 50mg, 250mg. Molecular Formula: C6H6N2O2S, Molecular Weight: 170.19. US Biological Life Sciences. | Worldwide |
| 3-Acetylaminophthalic Anhydride | 3-Acetylaminophthalic Anhydride is used in the synthesis of Apremilast, a potent phosphodiesterase 4 and tumor necrosis Factor-α inhibitor used in the treatment of psoriatic arthritis. Also a reagent in the preparation of Tillivalline. Apremilast Impurity 2. Group: Biochemicals. Grades: Highly Purified. CAS No. 6296-53-3. Pack Sizes: 1g, 10g. Molecular Formula: C10H7NO4, Molecular Weight: 205.17. US Biological Life Sciences. | Worldwide |
| 3-Amino-2,4-dibromopyridine | 3-Amino-2,4-dibromopyridine is a versatile reactant used in the synthesis of novel indolizine 2-oxoacetamides that are inhibitors of phosphodiesterase IV and tumor necrosis factor-α production in human peripheral blood mononuclear cell. Group: Biochemicals. Grades: Highly Purified. CAS No. 102249-45-6. Pack Sizes: 50mg, 250mg. Molecular Formula: C5H4Br2N2, Molecular Weight: 251.91. US Biological Life Sciences. | Worldwide |
| Abz-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (669-674)-EDDnp | Abz-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (669-674)-EDDnp is an intramolecularly quenched fluorescent substrate with the ortho-aminobenzoyl (Abz)/N-(2,4-dinitrophenyl)ethylenediamine (EDDnp) groups as the donor/acceptor pair. It corresponds to the Swedish-mutated (JMV2236) β-amyloid precursor protein (βAPP) sequence, which is targeted by β-secretase BACE (β-site APP-cleaving activity). It is more selectively cleaved by BACE1 and BACE2 than by cathepsin D, a disintegrin and metalloprotease 10 (ADAM10), tumor necrosis α-converting enzyme (TACE), presenilin-1 (PS1), or presenilin-2 (PS2). Synonyms: JMV2236; L-α-Glutamine, N-(2-aminobenzoyl)-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-N-[2-[(2,4-dinitrophenyl)amino]ethyl]-; N-(2-Aminobenzoyl)-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-N-{2-[(2,4-dinitrophenyl)amino]ethyl}-L-α-glutamine. Grades: ≥95%. CAS No. 1007306-20-8. Molecular formula: C42H58N12O16. Mole weight: 986.99. | |
| ADAM 17 endopeptidase | In peptidase family M12. In vivo, the cleavage of tumour necrosis factor α precursor releases the soluble, 17-kDa TNFα, which induces inflammation. Group: Enzymes. Synonyms: tumor necrosis factor α-converting enzyme; TACE. Enzyme Commission Number: EC 3.4.24.86. CAS No. 151769-16-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4370; ADAM 17 endopeptidase; EC 3.4.24.86; 151769-16-3; tumor necrosis factor α-converting enzyme; TACE. Cat No: EXWM-4370. |  |
| Afelimomab | Afelimomab (MAK 195F) is an anti-tumor necrosis factor F(ab')2 monoclonal antibody fragment. Afelimomab can be used for the research of sepsis [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: MAK 195F. CAS No. 156227-98-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99425. | |
| AG 126 | Tyrphostins are protein tyrosine kinase inhibitors developed to inhibit cell growth through blocking the activity of certain GFRK (growth factor receptor kinases). AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. It also inhibits the production of TNF-α (tumor necrosis factor-α), attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in animal models. AG 126 is a poor inhibitor of epidermal GFRK with IC50 of 450 μM and platelet-derived GFRK with IC50 > 100 μM. AG 126 may represent a new approach for the therapy of inflammation. Uses: Anti- inflammation. Synonyms: AG126; AG-126; Tyrphostin AG 126; UNII-7YA4AMD1JC; Tyrphostin A 10; alpha-Cyano-(3-hydroxy-4-nitro)cinnamonitrile. Grades: 95%. CAS No. 118409-62-4. Molecular formula: C10H5N3O3. Mole weight: 215.16. | |
| AITRL human | AITRL, a cytokine belonging to the tumor necrosis factor (TNF) ligand superfamily, is expressed in endothelial cells, and signals through the AITR receptor. AITRL regulates T-cell proliferation and survival, and effectuates the interaction between T lymphocytes and endothelial cells. AITRL is a ligand for receptor TNFRSF18/AITR/GITR. GITR/AITRL interaction plays a role in the pathogenesis of tumors, inflammation, and autoimmune diseases. In addition, AITRL is involved in endothelial cell (EC) activation and increases STAT-1 phosphorylation and the expression of adhesion molecules (VCAM-1, ICAM-1). Synonyms: Activation-induced TNFR member Ligand; TNFSF18; rHuActivation-inducible TNF-related Ligand/AITRL; GITRL; TL-6; Tumor necrosis factor ligand superfamily member 18; rHuAITRL; GITR Ligand. Grades: ≥98% by HPLC. Mole weight: ~14.3 kDa. | |
| Aminopeptidase N Ligand (CD13), NGR peptide | It is a peptide with NGR (Asn-Gly-Arg) motif, which has a disulfide bridge linking cys1 and cys5, and is known to have antimicrobial properties in addition to the presence of KLA sequences. The peptide binds to CD13 on tumor cells and shows strong cytotoxicity and activity against tumor cells. This peptide shows dose-dependent antiproliferation against tumor cells and induces cell cylce arrest at G2/M phases and apoptosis of the tumor cells. Peptides containing the NGR motif are useful in the delivery of cytotoxic drugs, pro-apoptotic peptides, and tumor necrosis factor (TNF) into tumor vasculature. Synonyms: H-Cys-Asn-Gly-Arg-Cys-Gly-OH (Disulfide bridge: Cys1-Cys5); L-cysteinyl-L-asparagyl-glycyl-L-arginyl-L-cysteinyl-glycine (1->5)-disulfide; N-{[(4R,5E,7S,8E,11E,13S,14E,16R)-16-Amino-7-(3-carbamimidamidopropyl)-6,9,12,15-tetrahydroxy-13-(2-hydroxy-2-iminoethyl)-1,2-dithia-5,8,11,14-tetraazacycloheptadeca-5,8,11,14-tetraen-4-yl](hydroxy)methylene}glycine. Grades: ≥95%. Molecular formula: C20H34N10O8S2. Mole weight: 606.67. | |
| Andrographolide | Andrographolide is a labdane diterpenoid. Andrographolide is the main bioactive component isolated from the medicinal plant Andrographis paniculata. Andrographolide showed significant antihepatotoxic action in P. berghei K173- induced hepatic damage in M. natalensis. Andrographolide inhibits tumor necrosis factor-α (TNF-α)-induced intercellular adhesion mol.-1 (ICAM-1) expression and adhesion of HL-60 cells onto human umbilical vein endothelial cells (HUVEC), which are associated with inflammatory diseases. These findings suggest that Andrographolide may have potential as a cardiovascular-protective agent. Group: Biochemicals. Alternative Names: (3E, 4S) -3- [2- [ (1R, 4aS, 5R, 6R, 8aS) -Decahydro-6-hydroxy-5- (hydroxymethyl) -5, 8a-dimethyl-2-methylene-1-naphthalenyl] ethylidene] dihydro-4-hydroxy-2 (3H) -furanone; [1R-[1α[E(S*)],4a β , 5α , 6α , 8aα ] ] -3- [2- [Decahydro-6-hydroxy-5- (hydroxymethyl) -5, 8a-dimethyl-2-methylene-1-naphthalenyl] ethylidene] dihydro-4-hydroxy-2 (3H) -furanone; 3α,14,15,18-Tetrahydroxy-5 β,9 βH,10α-labda-8(20),12-dien-16-oic Acid γ-Lactone; Andrographis; Andrographolid. Grades: Highly Purified. CAS No. 5508-58-7. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
| Anisodamine | Anisodamine, an anticholinergic drug, has antishock effect, which is intimately linked to alpha7nAChR-dependent anti-inflammatory pathway. Anisodamine demonstrates a direct cardiac depressive action at the myocyte level, which may be related to, at least in part, NO production and cholinoceptor antagonism, it causes the changes of structure and function in the transmembrane domain of the Ca(2+)-ATPase from sarcoplasmic reticulum. Anisodamine, a vasoactive drug, can abate endogenous endotoxaemia subsequent to splanchnic vasoconstriction due to hypovolaemia, it alleviates inflammatory damage by significantly reducing the expressions of VEGF and ICAM-1, and shows significant protective effects in an animal model of infusion phlebitis. Anisodamine also inhibits shiga toxin type 2-mediated tumor necrosis factor-alpha production in vitro and in vivo. Group: Biochemicals. Grades: Plant Grade. CAS No. 55869-99-3. Pack Sizes: 100mg. Molecular Formula: C17H23NO4, Molecular Weight: 305.374. US Biological Life Sciences. | Worldwide |
| APRIL from mouse | APRIL (a proliferation-inducing ligand), also known as tumor necrosis factor ligand superfamily member 13 (TNFSF13), is a protein of the TNF superfamily recognized by the cell surface receptor TACI. APRIL protein (CD256) can induce proliferation, regulate tumor cell growth, and may participate in mononuclear/macrophage-mediated immune process. APRIL protein has been widely used in the study of lymphatic malignancies. Synonyms: A Proliferating-inducing Ligand; TNFSF13; TRDL-1a; APRIL/TNFSF13 Protein, Mouse; rMuApril/TNFSF13; TNFSF 13; TNFSF-13; CD256. Grades: ≥98% by HPLC. Mole weight: ~21.9 kDa. | |
| APRIL human | APRIL (a proliferation-inducing ligand), also known as tumor necrosis factor ligand superfamily member 13 (TNFSF13), is a protein of the TNF superfamily recognized by the cell surface receptor TACI. APRIL protein (CD256) can induce proliferation, regulate tumor cell growth, and may participate in mononuclear/macrophage-mediated immune process. APRIL protein has been widely used in the study of lymphatic malignancies. Synonyms: A Proliferating-inducing Ligand; TNFSF13; TRDL-1a; APRIL/TNFSF13 Protein, Mouse; rMuApril/TNFSF13; TNFSF 13; TNFSF-13; CD256; TALL-2; TALL2; TNLG7B; TRDL-1; UNQ383/PRO715; ZTNF2. Grades: ≥95% by HPLC. Mole weight: ~16.3 kDa. | |
| Asiatic acid | Asiatic acid, a pentacyclic triterpene found in Centella asiatica ( Centella asiatica ), has anticancer activity. Asiatic acid induces apoptosis in melanoma cells and has barrier protective effects on human aortic endothelial cells (HAEC). Asiatic acid also has anti-inflammatory activity and inhibits tumor necrosis factor (TNF)-α-induced endothelial barrier dysfunction. Asiatic acid also inhibits NLRP3 inflammasome activation and NF-κB pathway, effectively inhibits inflammation in rats, and has neuroprotective effects in rat spinal cord injury (SCI) model [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 464-92-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0194. | |
| Asiaticoside | Antibacterial. Human collagen I synthesis inducer. Anti-wrinkle activity. Shows wound healing activity. Enhances normal human skin cell migration, attachment and growth. Suppresses collagen expression and TGF-beta/Smad signaling by inducing Smad7 and inhibiting TGF-betaRI and TGF-betaRII. Anti-inflammatory. Anti-gastric ulcer. Mitogen-activated protein kinases (MAPKs), nuclear factor-kappaB (NF-kappaB), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOSII) expression, production of serum tumor necrosis factor (TNF-alpha) and interleukin-6 (IL-6) inhibitor. Apoptosis inducer in cancer cells. Enhances antitumor activity of vincristine in cancer cells. Might be useful in cancer chemotherapy. Anxiolytic. Antidepressant-like activity. Hepatoprotective effects. CYP2C19 and CYP3A4 inhibitor. Neuroprotective. Antileishmanial activity. cPLA2 and sPLA2 inhibitor. Group: Biochemicals. Alternative Names: Blastostimulina, Centelase, Emdecassol, Madecassol, Marticassol, FK1080, BRN 0078195, NSC 166062. Grades: Highly Purified. CAS No. 16830-15-2. Pack Sizes: 10mg, 50mg. Molecular Formula: C48H78O19. US Biological Life Sciences. | Worldwide |
| Atizoram | Atizoram (CP-80,633), a cyclic nucleotide phosphodiesterase (PDE4) inhibitor, elevates plasma cyclic AMP levels and decreases tumor necrosis factor-α (TNFα) production in mice [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CP-80,633. CAS No. 135637-46-6. Pack Sizes: 500 μg. Product ID: HY-108623. | |
| Atractyloside, Calcium Salt | Atractyloside Calcium Salt is a specific inhibitor of the adenine nucleotide translocase (ANT), which is a mitochondrial ADP/ATP carrier. It is also a proapoptotic ligand of ANT that induces pore formation by ANT, and results in permeabilization of the mitochondria membrane. Studies on rat hearts suggest that Atractyloside inhibits chloride channels from the mitochondrial membrane. It is used to probe the source of procaspase 8 in human fibroblasts and mouse clonal striatal cells, as related to death receptor-mediated apoptosis. Atractyloside induces the release of ahyaluronidase-induced murine WW domain-containing oxidoreductase from cultured COS-7 cells, with respect to tumor necrosis factor cytotoxicity. Group: Biochemicals. Alternative Names: (2 β,15α)-15-Hydroxy-2-[[2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo- β-D-glucopyranosyl]oxy]-19-Norkaur-16-en-18-oic Acid Calcium Salt; 19-Norkaur-16-en-18-oic acid deriv. 1H-2,10a-Ethanophenanthrene Calcium Salt. Grades: Highly Purified. CAS No. 772298-35-8 free acid. Pack Sizes: 500ug, 1mg. US Biological Life Sciences. | Worldwide |
| BioGEE | BioGEE is an excellent marker for reversible redox modification of several proteins in conjunction with tumor necrosis factor α-stimulated apoptosis. Also, it is derived from Fmoc-Cys(Trt)-OH (F679775). Group: Biochemicals. Grades: Highly Purified. CAS No. 502635-76-9. Pack Sizes: 10mg, 25mg. Molecular Formula: C24H39N5O8S2, Molecular Weight: 589.73. US Biological Life Sciences. | Worldwide |
| BMS561392 | BMS561392 is a tumor necrosis factor-alpha (TNF alpha) converting enzyme inhibitor. It has the potential treatment of diseases characterized by overproduction of TNF alpha, such as rheumatoid arthritis (RA). It was developed by Bristol-Myers Squibb and was in clinic phase 2 trials, but now it is terminated. Uses: Bms561392 has the potential treatment of diseases characterized by overproduction of tnf alpha, such as rheumatoid arthritis (ra). Synonyms: BMS-561392; BMS561392; BMS 561392; DPC-333; DPC 333; DPC333. (αR,?3R)?-3-Amino-N-hydroxy-α-(2-methylpropyl)?-3-[4-[(2-methyl-4-quinolinyl)?methoxy]?phenyl]?-2-oxo-1-pyrrolidineacetamide?;BMS-561392;DPC-333;(2R)-2-[(3R)-3-amino-3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-1-yl]-N-hyd. Grades: 98%. CAS No. 611227-74-8. Molecular formula: C27H32N4O4. Mole weight: 476.57. | |
| Butein | Butrin, isobutrin, and butein from medicinal plant Butea monosperma selectively inhibit nuclear factor-κB in activated human mast cells: suppression of tumor necrosis factor-α, interleukin (IL)-6, and IL-8. Anti-inflammatory agent. Group: Biochemicals. Alternative Names: (2E)-1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one; 2',3,4,4'-Tetrahydroxychalcone. Grades: Highly Purified. CAS No. 487-52-5. Pack Sizes: 20mg, 50mg, 100mg, 250mg. Molecular Formula: C??H??O?, Molecular Weight: 272.25. US Biological Life Sciences. | Worldwide |
| CDC801 | A potent, orally active and dual inhibitor of phosphodiesterase 4 (PDE4) (IC50= 1.1 μM) and tumor necrosis factor-α (TNF-α) (IC50= 2.5 μM). Synonyms: CDC801; CDC 801; CDC-801; 3-(3-cyclopentyloxy-4-methoxyphenyl)-3-(1,3-dioxoisoindol-2-yl)propanamide. CAS No. 192819-27-5. Molecular formula: C23H24N2O5. Mole weight: 408.45. | |
| Celastramycin A | Celastramycin A is a bioactive compound isolated from endophytic bacteria. Celastramycin A exhibited high activity against a series of multiresistent bacteria and mycobacteria. It inhibits the growth of Gram-positive bacteria and mycobacteria with minimal inhibitory concentration (MIC). Celastramycin A suppresses the production of interleukin-8 in human umbilical vein endothelial cells as stimulated by tumor necrosis factor-α with IC50 of 0.01 μg/ml. It can also be used as a lead compound for novel immunosuppressive agents. Grades: ≥97%. CAS No. 491600-94-3. Molecular formula: C17H18Cl3NO3. Mole weight: 390.69. | |
| CHF 5074 | CHF 5074 is a novel γ-secretase modulator. It reduces Aβ42 and Aβ40 secretion with IC50 values of 3.6 and 18.4 μM respectively. It protects SH-SY5Y human neuronal-like cells from amyloidbeta 25-35 and tumor necrosis factor related apoptosis inducing ligand toxicity in vitro. Uses: Chf5074 induces microglia alternative activation in plaque-free tg2576 mice and primary glial cultures exposed to beta-amyloid. it restores visual memory ability and pre-synaptic cortical acetylcholine release in pre-plaque tg2576 mice. it is a non-steroidal anti-inflammatory derivative holding disease-modifying potential for the treatment of alzheimer's disease. it significantly reduces the apoptosis in hippocampal neurons exposed to ogd, as revealed by cleaved-caspase-3 immunoreactivity and tunel staining. Synonyms: CHF-5074; Itanapraced; 1-[4-(3,4-dichlorophenyl)-3-fluorophenyl]cyclopropane-1-carboxylic acid. Grades: >98%. CAS No. 749269-83-8. Molecular formula: C16H11Cl2FO2. Mole weight: 325.16. | |
| Cholesteryl hemisuccinate | Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesteryl hemisuccinate inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth. Group: Inhibitors. Alternative Names: Cholesteryl hydrogen succinate. CAS No. 1510-21-0. Molecular formula: C31H50O4. Mole weight: 486.7. Appearance: A crystalline solid. Purity: ≥95%. IUPACName: 4-[[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-4-oxobutanoic acid. Canonical SMILES: CC (C)CCCC (C)C1CCC2C1 (CCC3C2CC=C4C3 (CCC (C4)OC (=O)CCC (=O)O)C)C. Density: 1.06±0.1 g/cm³ (Predicted). ECNumber: 216-148-6. Catalog: ACM1510210. |  |
| Cholesteryl hemisuccinate | Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesteryl hemisuccinate inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth. Group: Liquid crystal (lc) materials. Alternative Names: Cholesteryl hydrogen succinate. CAS No. 1510-21-0. Pack Sizes: 10 g. Product ID: 4-[[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-4-oxobutanoic acid. Molecular formula: 486.7. Mole weight: C31H50O4. CC (C)CCCC (C)C1CCC2C1 (CCC3C2CC=C4C3 (CCC (C4)OC (=O)CCC (=O)O)C)C. InChI=1S/C31H50O4/c1-20 (2)7-6-8-21 (3)25-11-12-26-24-10-9-22-19-23 (35-29 (34)14-13-28 (32)33)15-17-30 (22, 4)27 (24)16-18-31 (25, 26)5/h9, 20-21, 23-27H, 6-8, 10-19H2, 1-5H3, (H, 32, 33)/t21-, 23+, 24+, 25-, 26+, 27+, 30+, 31-/m1/s1. WLNARFZDISHUGS-MIXBDBMTSA-N. ≥95%. |  |
| CID 2858522 (Selectively Inhibits PKC-induced NF-kB Activation, 1-[3,5-Bis(1,1-dimethylethyl)-4-hyd roxyphenyl]-2-[2-[(3-hydroxypropyl)amino]-5,6-dime thyl-1H-benzimidazol-1-yl]ethanone) | Selectively inhibits protein kinase C (PKC)-induced activation of the NF-kappaB pathway (IC50 < 0.1um for PMA-stimulated IL-8 production). Inhibits antigen receptor-stimulated NF-kappaB activation in chronic lymphocytic leukemia (CLL) B cells. Does not inhibit other NF-kappaB pathways, including that activated by tumor necrosis factor (TNF). Group: Biochemicals. Grades: Highly Purified. CAS No. 758679-97-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| CKD-516 HCl | CKD-516 is tubulin inhibitor for solid cancer, which was initiated phase 1 trial in Korea in 2010. CKD-516 selectively disrupted tubulin component of the endothelial cytoskeleton. Serial DCE-MRI showed a significant decrease in K-trans and IAUGC parameters from baseline at 4 h (39.9 % in K-trans; -45.0 % in IAUGC) and at 24 h (-32.2 % in K-trans; -36.5 % in IAUGC), and a significant recovery at 48 h (22.9 % in K-trans; 34.8 % in IAUGC) following administration of CKD-516 at a 0.7-mg/kg dose. When the tumors were stratified according to the initial K-trans value of 0.1, tumors with a high K-trans?>?0.1 which was indicative of having well-developed pre-existing vessels, showed greater reduction in K-trans and IAUGC values. On histologic examination, the degree of necrosis of treated tumors was significantly greater than that of untreated tumors. In summary, CKD-516 is an effective VDA which results in rapid vascular shutdown by targeting the tubulin component of tumor vessels and thus leads to necrosis. Synonyms: Valecobulin hydrochloride; CKD516 hydrochloride; CKD 516 hydrochloride. CAS No. 1240321-53-2. Molecular formula: C26H29ClN6O5S. Mole weight: 573.07. | |
| Clenbuterol EP Impurity B HCl | Clenbuterol EP Impurity B HCl is an impurity of Clenbuterol and is used as a reagent in the synthesis of pyrazolopyridine derivatives as inhibitors of phosphodiesterase-4 (PDE-IV) and production of tumor necrosis factor-α (TNF-α). Synonyms: 1-(4-Amino-3,5-dichlorophenyl)-2-(tert-butylamino)ethan-1-one, hydrochloride (1:1); 4-Amino-α-(tert-butylamino)-3,5-dichloroacetophenone Hydrochloride; Keto Clenbuterol. CAS No. 37845-71-9. Molecular formula: C12H17Cl3N2O. Mole weight: 311.63. | |
| Clenbuterol Impurity 1 | Clenbuterol Impurity 1 is an impurity of Clenbuterol and is used as a reagent in the synthesis of pyrazolopyridine derivatives as inhibitors of phosphodiesterase-4 (PDE-IV) and production of tumor necrosis factor-α (TNF-α). Molecular formula: C8H6Br2ClNO. Mole weight: 327.4. | |
| Clenbuterol Impurity A | 4-Amino-3,5-dichlorobenzaldehyde is an impurity of Clenbuterol and is used as a reagent in the synthesis of pyrazolopyridine derivatives as inhibitors of phosphodiesterase-4 (PDE-IV) and production of tumor necrosis factor-α (TNF-α). 4-Amino-3,5-dichlorobenzaldehyde is also used as a reagent in the synthesis of amino acid derivatives as neuropeptide Y antagonists. Synonyms: 4-Amino-3,5-dichlorobenzaldehyde. Grades: > 95%. CAS No. 62909-66-4. Molecular formula: C7H5Cl2NO. Mole weight: 190.03. | |
| Clenbuterol Impurity E | Clenbuterol Impurity E is an impurity of Clenbuterol and is used as a reagent in the synthesis of pyrazolopyridine derivatives as inhibitors of phosphodiesterase-4 (PDE-IV) and production of tumor necrosis factor-α (TNF-α). Synonyms: 4-Amino-3,5-dichlorophenacylbromide; 1-(4-Amino-3,5-dichlorophenyl)-2-bromoethan-1-one. Grades: 95%. CAS No. 37148-47-3. Molecular formula: C8H6BrCl2NO. Mole weight: 282.95. | |
| Clencyclohexerol | Clencyclohexerol is an analog of Clenbuterol and is used as a reagent in the synthesis of pyrazolopyridine derivatives as inhibitors of phosphodiesterase-4 (PDE-IV) and production of tumor necrosis factor-α (TNF-α). Uses: An analog of clenbuterol, a β-agonist which can be used as a growth promoter in farm animals. Synonyms: 4-Amino-3, 5-dichloro-α -[[ (4-hydroxycyclohexyl) amino]methyl]benzenemethanol; Benzenemethanol, 4-amino-3,5-dichloro-α-[[(4-hydroxycyclohexyl)amino]methyl]-; 4-{[2-(4-Amino-3,5-dichlorophenyl)-2-hydroxyethyl]amino}cyclohexanol. Grades: 98%. CAS No. 157877-79-7. Molecular formula: C14H20Cl2N2O2. Mole weight: 319.23. | |
| Coptisine sulfate | Coptisine sulfate is a natural compound that belongs to the group of plant alkaloids. It has been shown to have anti-inflammatory properties, significant cytotoxicity, and significant mitochondrial membrane potential in myeloma cells. Coptisine sulfate inhibits toll-like receptor 4 (TLR4), which is a protein present on the surface of immune cells. Coptisine sulfate has been shown to inhibit the production of cytokines such as tumor necrosis factor alpha (TNF-α) and IL-6 by these cells. Coptisine sulfate also inhibits the activation of nuclear factor kappa B (NFκB) and mitogen activated protein kinase (MAPK). This inhibition leads to reduced levels of proinflammatory cytokines and chemokines, such as IL-1β, IL-8, MCP1, and GRO&alpha. Group: Other alkaloids. CAS No. 1198398-71-8. Molecular formula: C38H28N2O12S. Mole weight: 736.7 g/mol. Canonical SMILES: C1C[N+]2=C (C=C3C=CC4=C (C3=C2)OCO4)C5=CC6=C (C=C51)OCO6. Catalog: ACM1198398718. | |
| crisaborole | Crisaborole is a novel PDE-4 inhibitor used as a nonsteroidal topical medication for the treatment of mild-to-moderate atopic dermatitis (eczema). Crisaborole selectively inhibits PDE-4B which mainly leads to inflammation. Tumor necrosis factor alpha (TNFα), interleukin-12 (IL-12), IL-23 and other cytokines are also suppressed while crisaborole functioning. Uses: The treatment of mild-to-moderate atopic dermatitis (eczema). Synonyms: AN2728; AN-2728; AN 2728; Crisaborole; Eucrisa; 4-((1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)benzonitrile. Grades: 99%. CAS No. 906673-24-3. Molecular formula: C14H10BNO3. Mole weight: 251.048. | |
| CroCin | Crocin is a water-soluble carotenoid pigment in saffron (Crocus sativus L.) with anti-inflammatory, antioxidant, anti-apoptosis, anti-asthma, anti-cancer, anti-allergy, relaxation of smooth muscle and hypolipidemic effects. Crocin inhibits tumor necrosis factor (TNF) α-induced pheochromocytoma (PC12) apoptosis by regulating the mRNA expression of Bcl-2 family proteins, which trigger downstream signals that ultimately lead to caspase-3 activation and subsequent cell death. Uses: Antioxidant, anticancer. Synonyms: Crocin (Gardenia Fruits Extract); β-D-Glucopyranose, 6-O-β-D-glucopyranosyl-, 1,1'-[(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate]; 8,8'-Diapo-ψ,ψ-carotenedioic acid, bis(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl) ester; all-trans-Crocetin di-β-D-gentiobiosyl ester; Crocetin bis(gentiobiosyl) ester; Crocetin di(β-D-gentiobiosyl) ester; Crocetin di-β-gentiobiosyl ester; Crocetin digentiobioside; Crocin 1; Crocin 4; Crocin A; Crocin I; Kiriyasu Oil Yellow GY; trans-Crocetin di(β-D-gentiobiosyl) ester; Trans-crocin-1; trans-Crocin-1; Trans-crocin-4; α-Crocin. Grades: >98%. CAS No. 42553-65-1. Molecular formula: C44H64O24. Mole weight: 976.96. | |
| Crolibulin | Crolibulin, also known as EPC2407 and crinobulin, is a small molecule tubulin polymerization inhibitor with potential antineoplastic activity. Microtubulin inhibitor EPC2407 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of tubulin into microtubules, which may result in cell cycle arrest, the induction of apoptosis, and the inhibition of tumor cell proliferation. As a vascular disruption agent (VDA), this agent also disrupts tumor neovascularization, which may result in a reduction in tumor blood flow and tumor hypoxia and ischemic necrosis. Synonyms: EPC2407; EPC 2407; EPC-2407; (R)-2,7,8-triamino-4-(3-bromo-4,5-dimethoxyphenyl)-4H-chromene-3-carbonitrile. CAS No. 1000852-17-4. Molecular formula: C18H17BrN4O3. Mole weight: 417.263. | |
| Cudraflavone B | Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-tumor properties. Cudraflavone B is also a dual inhibitor of COX-1 and COX-2. Cudraflavone B blocks the translocation of nuclear factor κB (NF-κB) from the cytoplasm to the nucleus in macrophages. Thus, Cudraflavone B inhibits tumor necrosis factor α (TNFα) gene expression and secretion. Cudraflavone B also triggers the mitochondrial apoptotic pathway, activates NF-κB, the MAPK p38, and ERK, and induced the expression of SIRT1. Thus Cudraflavone B inhibits the growth of human oral squamous cell carcinoma cells. Group: Inhibitors. CAS No. 19275-49-1. Molecular formula: C25H24O6. Mole weight: 420.45. Appearance: Powder. Purity: 0.98. IUPACName: 8-(2,4-dihydroxyphenyl)-5-hydroxy-2,2-dimethyl-7-(3-methylbut-2-enyl)pyrano[3,2-g]chromen-6-one. Canonical SMILES: CC (=CCC1=C (OC2=CC3=C (C=CC (O3) (C)C)C (=C2C1=O)O)C4=C (C=C (C=C4)O)O)C. Catalog: ACM19275491. | |
| Cyclopenin | Cyclopenin is one of an unusual family of benzodiazepine metabolites produced by a number of Penicllium species. Often mistakenly referred to as a mycotoxin, cyclopenin shows little toxicity against mammalian cells, bacteria or fungi in vitro. Cyclopenin is an intermediate in the biosynthesis of 3-O-methyl viridicatin, a strong inhibitor of the tumor necrosis factor alpha (TNF)-induced replication of human immunodeficiency virus (HIV). Lack of availability has hitherto restricted a more intensive investigation of this interesting metabolite. Group: Biochemicals. Grades: Highly Purified. CAS No. 19553-26-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Cynaropicrin | Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC50s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-κBsignaling. Group: Inhibitors. CAS No. 35730-78-0. Molecular formula: C19H22O6. Mole weight: 346.37. Purity: 0.97. Catalog: ACM35730780. | |
| Cynaropicrin | Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor ( TNF-α ) release with IC 50 s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor ( MMP13 ) and suppresses NF-κB signaling. Uses: Scientific research. Group: Natural products. CAS No. 35730-78-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N2350. | |
| DAT-230 | DAT-230 is a promising microtubule inhibitor that has great potential for the treatment of fibrosarcoma in vitro and in vivo. DAT-230 exhibited potent anti-proliferative activity against various cancer cells. DAT-230-treatment in HT-1080 cells resulted in microtubule de-polymerization and G2/M phase arrest preceding apoptosis. Phosphor-cdc2 (thr14/tyr15) reduction, cyclin B1 accumulation and aberrant spindles denoted the cyclin B1-cdc2 complex active and M phase arrest in HT-1080 cells treated with DAT-230. Apoptosis induced by DAT-230 was related with the activation of caspase-9, caspase-3 and PARP cleavage, which were at the downstream of mitochondria. The decrease ratio of Bcl-2/Bax, elevation of NO and disruption of ΔΨm confirmed the causal relationship between DAT-230 and mitochondrial pathway. In vivo, DAT-230 delayed tumor growth, induced tumor perfusion decrease and extensive hemorrhagic-necrosis. Synonyms: DAT 230; DAT230. Grades: 98%. CAS No. 1504583-00-9. Molecular formula: C22H20BrN3O2S. Mole weight: 339.45. | |
| Daunorubicin | Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor. Group: Inhibitors. Alternative Names: 5,12-Naphthacenedione, 8-acetyl-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S,10S)-;Daunomycin. CAS No. 20830-81-3. Molecular formula: C27H29NO10. Mole weight: 527.52. Catalog: ACM20830813. | |
| Daunorubicin hydrochloride | Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin hydrochloride inhibits DNA and RNA synthesis. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor [1] [2] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride. CAS No. 23541-50-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13062. | |
| Eftozanermin alfa | Eftozanermin alfa (ABBV-621) is a second-generation tumor necrosis factor-related apoptosis-inducing ligand receptor ( TRAIL-R ) agonist. Eftozanermin alfa induces apoptosis in tumor cells by activation of death receptors 4/5. Eftozanermin alfa can be used for the research of multiple solid and heme malignancies [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: ABBV-621. CAS No. 1820660-69-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99934. | |
| Etanercept | Etanercept inhibits in vitro the activity of human TNF and is efficacious in many in vivo models of inflammation, including arthritis. Etanercept competitively inhibits the binding of both TNF-α and TNF-β (lymphotoxin-α) to cell surface TNF receptors, rendering TNF biologically inactive. It also modulates indirectly different biological responses that are induced or regulated by TNF, such as the expression of adhesion molecules E-selectin and to a lesser extent intercellular adhesion molecule 1 (ICAM-1), the production of interleukin-6 (IL-6) and matrix metalloproteinase 3 (MMP-3) (stromelysin), as well as IL1. Synonyms: 1-235-Tumor necrosisfactor receptor (human) fusion protein with 236-467-immunoglobulin G1 (human g1-chain Fc fragment); TNFR-Fc fusion protein; Etanercept; Embrel; Enbrel; rhu-TNFR-Fc. Grades: 95%. CAS No. 185243-69-0. Molecular formula: C2224H3472N618O701S36. | |
| Evodenoson | Evodenoson is a selective agonist of the A 2A adenosine receptor. Evodenosons primary actions include reducing inflammatory responses, decreasing intestinal fluid secretion, edema, tissue damage, and neutrophil infiltration induced by Clostridium difficile toxin A. Evodenosons protective effect is achieved by reducing myeloperoxidase (MPO) and adenosine deaminase (ADA) activities, and by lowering the production of tumor necrosis factor-alpha (TNF-α) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ATL 313; DE 112. CAS No. 844873-47-8. Pack Sizes: 1 mg. Product ID: HY-105017. | |
| Fazarabine | Fazarabine, also known as Kymarabine, is an orally-active pyrimidine analogue of an aza-substituted cytidine in which the ribose moiety is replaced by an arabinose sugar. Similar in action to cytarabine, fazarabine is phosphorylated by deoxycytidine kinase to a triphosphate form which competes with thymidine for incorporation into DNA; its incorporation into DNA inhibits DNA synthesis, resulting in tumor cell death and tumor necrosis. The presence of deoxycytidine kinase in a tumor is a determinant of tumor sensitivity to this drug. Synonyms: CCRIS 93; CCRIS-93; CCRIS93; NSC 281272; NSC-281272; NSC281272; Ara-AC; 5-Azacytosine arabinoside; 1-beta-D-Arabinofuranosyl-5-azacytosine. CAS No. 65886-71-7. Molecular formula: C8H12N4O5. Mole weight: 244.20. | |
| Flavine Adenine Dinucleotide-13C5 Ammonium Salt | Labelled Flavine Adenine Dinucleotide. The prosthetic group of certain flavoproteins including D-amino acid oxidase, glucose oxidase, glycine oxidase, fumaric hydrogenase, histaminase, and xanthine oxidase. Riboflavin kinase tumor necrosis factor receptor 1 NADPH oxidase. Synonyms: Riboflavin 5'-(Trihydrogen Diphosphate) P'5'-Ester with Adenosine-13C5 Ammonium Salt; Adenine-flavine Dinucleotide-13C5 Disodium; Adenine-riboflavin-13C5 Dinucleotide Ammonium Salt; Adenine-riboflavine-13C5 Dinucleotide Ammonium Salt; FAD-13C5 Ammonium Salt; Fademin-13C5 Ammonium Salt; Flavinat-13C5 Ammonium Salt; Flavine Adenosine Diphosphate-13C5 Ammonium Salt; Flavitan-13C5 Ammonium Salt; NSC 112207; Riboflavin-adenine Dinucleotide-13C5 Dinucleotide Ammonium Salt. Grades: 95%; 99% atom 13C. Molecular formula: C22[13C]5H33N9O15P2 xNH3. Mole weight: 790.51. | |
| Flavine Adenine Dinucleotide Disodium Salt | The prosthetic group of certain flavoproteins including D-amino acid oxidase, glucose oxidase, glycine oxidase, fumaric hydrogenase, histaminase, and xanthine oxidase. Riboflavin kinase tumor necrosis factor receptor 1 NADPH oxidase. Group: Biochemicals. Alternative Names: Riboflavin 5'-(Trihydrogen Diphosphate) P'5'-Ester with Adenosine. Grades: Highly Purified. CAS No. 146-14-5. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Fosbretabulin disodium | Fosbretabulin disodium is the disodium salt of a water-soluble phosphate derivative of a natural stilbenoid phenol derived from the African bush willow (Combretum caffrum) with potential vascular disrupting and antineoplastic activities. Upon administration, the prodrug fosbretabulin is dephosphorylated to its active metabolite, the microtubule-depolymerizing agent combretastatin A4, which binds to tubulin dimers and prevents microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial cells. In addition, this agent disrupts the engagement of the endothelial cell-specific junctional molecule vascular endothelial-cadherin (VE-cadherin) and so the activity of the VE-cadherin/β-catenin/Akt signaling pathway, which may result in the inhibition of endothelial cell migration and capillary tube formation. As a result of fosbretabulin's dual mechanism of action, the tumor vasculature collapses, resulting in reduced tumor blood flow and ischemic necrosis of tumor tissue. Synonyms: Combretastatin A-4 phosphate disodium, CA4P; CA4DP; Combretastatin A-4 phosphate. CAS No. 168555-66-6. Molecular formula: C18H19Na2O8P. Mole weight: 440.295. | |
| FSL-1-FLAG | Lipopeptide FSL-1, synthesized on the basis of the N-terminal structure of M. salivarium lipoprotein, can induce ICAM-1 expression on the surface of human gingival fibroblasts. In addition, it induces the production of monocyte chemoattractant protein 1, interleukin-6 (IL-6), and IL-8. It activates macrophages to produce tumor necrosis factor-alpha. Synonyms: Fibroblast Stimulating Lipopeptide 1 FLAG-tag; H-Cys((RS)-2,3-di(palmitoyloxy)-propyl)-Gly-Asp-Pro-Lys-His-Pro-Lys-Ser-Phe-Asp-Tyr-Lys-Asp-Asp-Asp-Asp-Lys-OH; L-Lysine, S-[2,3-bis[(1-oxohexadecyl)oxy]propyl]-L-cysteinylglycyl-L-α-aspartyl-L-prolyl-L-lysyl-L-histidyl-L-prolyl-L-lysyl-L-seryl-L-phenylalanyl-L-α-aspartyl-L-tyrosyl-L-lysyl-L-α-aspartyl-L-α-aspartyl-L-α-aspartyl-L-α-aspartyl-. Grades: ≥95%. CAS No. 2243206-97-3. Molecular formula: C125H198N24O37S. Mole weight: 2661.15. | |
| Gabexate Mesylate | Gabexate Mesylate is a serine protease inhibitor. Gabexate Mesylate inhibits trypsin, plasmin, plasma kallikrein and thrombin. Gabexate Mesylate inhibits lipopolysaccharide-induced tumor necrosis factor-α (TNF-α) production through nuclear factor-κB and activator protein-1 activation. Group: Biochemicals. Alternative Names: 4-[[6-[ (Aminoiminomethyl) amino]-1-oxohexyl]oxy]benzoic Acid Ethyl Ester Monomethanesulfonate; Arodate; FOY; FOY 007; FOY-S 983; Gabexate Mesilate; Gabexate Monomethanesulfonate; Megacert; Mesyl Gabexate. Grades: Highly Purified. CAS No. 56974-61-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Glycine-N-methylamide hydrochloride | 2-Amino-N-methylacetamide is an intermediate used to prepare macrocyclic hydroxamic acids that inhibit tumor necrosis factor &alpha. It is also used to synthesize 2-[(arylalkyl)amino]alkanamide derivatives with anticonvulsant activities. Synonyms: Gly-NHMe HCl; 2-Amino-N-methylacetamide hydrochloride; 2-amino-N-methylacetamide hydrochloric acid; N-Methylglycinamide hydrochloride; 2-Amino-N-methyl-acetamide HCl; H-Gly-NHMe HCl; glycine methylamide hydrochloride. Grades: ≥ 95%. CAS No. 49755-94-4. Molecular formula: C3H8N2O·HCl. Mole weight: 124.50. | |
| Guanine-7-oxide | Guanine-7-oxide is produced by the strain of Streptomyces sp. It has anti-tumor, anti-candida albicans activity, and can inhibit viral replication effect of herpes virus, infectious blood virus (IHNV), infectious pancreatic necrosis virus (IPNV) and so on. It has good activity against mouse L1210 leukemia cells. Synonyms: 7-Hydroxyguanine; Guanine 7-N-oxide; Guanine, N-7-oxide; Antibiotic PD 113876; 6H-Purin-6-one, 2-amino-1,7-dihydro-7-hydroxy-. CAS No. 5227-68-9. Molecular formula: C5H5N5O2. Mole weight: 167.13. | |
| Guanine-7-oxide hydrochloride | Guanine-7-oxide hydrochloride is produced by the strain of Streptomyces sp. It has anti-tumor, anti-candida albicans activity, and can inhibit viral replication effect of herpes virus, infectious blood virus (IHNV), infectious pancreatic necrosis virus (IPNV) and so on. It has good activity against mouse L1210 leukemia cells. Synonyms: 7-Hydroxyguanine hydrochloride; Guanine 7-N-oxide hydrochloride. Molecular formula: C5H5N5O2.HCl. Mole weight: 203.59. | |
| GW-3333 | GW-3333 is a dual inhibitors of tumor necrosis factor-alpha (TNF)-Converting Enzyme (TACE) and matrix metalloproteinases. Synonyms: GW-3333; GW3333; GW 3333; 3-[formyl(hydroxy)amino]-4-methyl-N-[3-methyl-1-oxo-1-(pyridin-2-ylamino)pentan-2-yl]-2-(2-methylpropyl)pentanamide. Grades: >98%. CAS No. 212609-68-2. Molecular formula: C22H36N4O4. Mole weight: 420.55. | |
| GYY-4137 Morpholine salt | GYY-4137 Morpholine salt is a novel water-soluble and slow releasing Hydrogen sulfide(H2S) donor. It protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis in rats. It inhibits the inflammatory response by suppressing the activation of nuclear factor-kappa B and mitogen-activated protein kinases in Coxsackie virus B3-infected rat cardiomyocytes. It exhibits potent anti-cancer activity. It exhibits vasodilator and antihypertensive activity in rats, in either the acute or chronic hypertension models. It does not influence vascular smooth muscle cell viability in culture. It also protects against endotoxic shock in rats, inhibiting tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 production and reducing NF-κB activation, iNOS and cyclooxygenase-2 expression, and NO and prostaglandin E2 generation. Uses: Gyy-4137 morpholine salt inhibits the inflammatory response. it exhibits potent anti-cancer activity. it exhibits vasodilator and antihypertensive activity. Synonyms: GYY4137; GYY-4137; GYY 4137; GYY 4137 morpholine salt; ZYJ1122; ZYJ 1122; ZYJ-1122. GYY4137 Morpholine salt;(4-Methoxyphenyl)morpholino-phosphinodithioic acid compound with morpholine;ZYJ1122 morpholine salt;ZYJ-1122 morpholine salt. Grades: ≥95%. CAS No. 106740-09-4. Molecular formula: C15H25N2O3PS2. Mole weight: 376.47. | |
| Imiquimod | Cell-permeable. Topical immune response modifier that displays anti-angiogenic, anti-viral and anti-inflammatory properties. Up-regulates IL-18 and down-regulates MMP-9 through recognition of Toll-like receptor 7 (TLR7) and subsequent activation of MyD88-dependent pathway. Stimulates proinflammatory cytokine production interferon-alpha (IFN-alpha), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) and activates NF-kappaB. Caspase-3 activator that directly induces procaspase-3 cleavage. Anti-cancer compound. Apoptosis inducer. Antiproliferative, independent of immune system activation or function. Approved treatment for external genital warts caused by human papillomavirus infection. Group: Biochemicals. Alternative Names: 1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine; R-837; S-26308. Grades: Highly Purified. CAS No. 99011-02-6. Pack Sizes: 100mg, 250mg, 500mg, 1g. Molecular Formula: C14H16N4. US Biological Life Sciences. | Worldwide |
| Incyclinide | incyclinide, also known as CMT-3 and COL-3, is a MMP inhibitor and achemically-modified tetracycline with potential antineoplastic activity. Incyclinide inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent also causes mitochondrial depolarization in tumor cells and induces both cellular apoptosis and tissue necrosis. Synonyms: Metastat; 4-dedimethylamino sancycline; CMT-3; CMT 3; CMT3; COL 3; COL3; COL-3. CAS No. 15866-90-7. Molecular formula: C19H17NO7. Mole weight: 371.34. | |
| Infliximab | Infliximab is a monoclonal antibody drug that is used for the treatment of rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, Crohn's disease, and ankylosing spondylitis. It binds to tumor necrosis factor alpha (TNF-α), which plays a role in the autoimmune reation. Infliximab may lead to fatal infections yet. Synonyms: Immunoglobulin G, anti-(human tumor necrosis factor) (human-mouse monoclonal cA2 heavy chain), disulfide with human-mouse monoclonal cA2 light chain, dimer; Avakine; Remicade; Remsima. Grades: 95%. CAS No. 170277-31-3. | |
| Mapatumumab | Mapatumumab (HGS-ETR1) is a fully human IgG1 agonistic monoclonal antibody that targets tumor necrosis factor-related apoptosis-inducing ligand receptor 1 ( TRAIL-R1 ). Mapatumumab can be used for the research of cancer [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: HGS-ETR1; Anti-Human TNFRSF10A Recombinant Antibody. CAS No. 658052-09-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99265. | |
| Mesopram | Mesopram is an orally active, selective phosphodiesterase (PDE) 4 inhibitor. In vitro, mesopram selectively inhibits the activity of type 1 helper T (Th1) cells without affecting cytokine production or proliferation of type 2 helper T (Th2) cells. It decreases the synthesis of tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma). Some studies conclude that the specific type-4 phosphodiesterase inhibitor mesopram ameliorates murine colitis both in a preventive and a therapeutic setting. Synonyms: (R)-5-(4-Methoxy-3-propoxyphenyl)-5-methyl-2-oxazolidinone. Grades: ≥98% by HPLC. CAS No. 189940-24-7. Molecular formula: C14H19NO4. Mole weight: 265.31. | |
| Methyl 4-Ethoxy-1,3-dimethyl-1H-pyrazole-5-carboxylate | Methyl 4-Ethoxy-1,3-dimethyl-1H-pyrazole-5-carboxylate is an intermediate of Clenbuterol and is used as a reagent in the synthesis of pyrazolopyridine derivatives as inhibitors of phosphodiesterase-4 (PDE-IV) and production of tumor necrosis factor-α (TNF-α). Synonyms: 1H-Pyrazole-5-carboxylic acid, 4-ethoxy-1,3-dimethyl-, methyl ester; 4-Ethoxy-1,3-dimethyl-1H-pyrazole-5-carboxylate methyl ester. Molecular formula: C9H14N2O3. Mole weight: 198.22. | |
| MIF-Antagonist, ISO-1 (S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole Acetic Acid, Methyl Ester) | Cell-permeable. A macrophage migration inhibitory factor (MIF) antagonist. ISO-1 inhibits MIF pro-inflammatory activities by targeting MIF tautomerase activity. Also inhibits tumor necrosis factor (TNF) release from macrophages isolated from LPS-treated wild type mice but has no effect on cytokine release from MIF deficient macrophages. Group: Biochemicals. Grades: Highly Purified. CAS No. 478336-92-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
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