Wild Suppliers USA
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Product | Description | |
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Wild Berries (radionuclide activity concentration) Quick inquiry Where to buy Suppliers range | Wild Berries (radionuclide activity concentration). Uses: For analytical and research use. Group: Environmental Food Contaminants. Catalog: APS013814. Shipping: Room Temperature. | |
Wild Jujube Seed (Zizyphus Spinosa) P.E. 4:1 Quick inquiry Where to buy Suppliers range | Wild Jujube Seed (Zizyphus Spinosa) P.E. 4:1. | CA, FL & NJ |
Wild Lettuce PE 5:1Wild Lettuce P.E. 5:1 Quick inquiry Where to buy Suppliers range | Wild Lettuce PE 5:1Wild Lettuce P.E. 5:1. | CA, FL & NJ |
Wild yam p.e.,diosgenin,uv,40% Quick inquiry Where to buy Suppliers range | Wild yam p.e.,diosgenin,uv,40%. Group: Heterocyclic Organic Compound. CAS No. 1372346-24-1. | |
Wild Yam Powder Quick inquiry Where to buy Suppliers range | Wild Yam Powder. | CA, FL & NJ |
Fish Collagen Powder (Wild) Quick inquiry Where to buy Suppliers range | Fish Collagen Powder (Wild). | CA, FL & NJ |
HLA-A_02_01 gp100 (wild) tetramer-ITDQVPFSV-APC labeled Quick inquiry Where to buy Suppliers range | HLA-A_02_01 gp100 (wild) tetramer-ITDQVPFSV-APC labeled. Uses: MHC-peptides Tetramer Class ?. Product ID: CPM-1-0638. | |
HLA-A_02_01 gp100 (Wild) tetramer-ITDQVPFSV-BV421 labeled Quick inquiry Where to buy Suppliers range | HLA-A_02_01 gp100 (Wild) tetramer-ITDQVPFSV-BV421 labeled. Uses: MHC-peptides Tetramer Class ?. Product ID: CPM-1-0561. | |
HLA-A_02_01 gp100 (wild) tetramer-ITDQVPFSV-PE labeled Quick inquiry Where to buy Suppliers range | HLA-A_02_01 gp100 (wild) tetramer-ITDQVPFSV-PE labeled. Uses: MHC-peptides Tetramer Class ?. Product ID: CPM-1-0092. | |
1,2-Dibromo-3-phenoxybenzene Quick inquiry Where to buy Suppliers range | 1,2-Dibromo-3-phenoxybenzene. Uses: 1,2-Dibromo-3-phenoxybenzene is a polybrominated diphenyl ether that functions as a flame retardant. It is also an environmental contaminant and might activate the aryl hydrocarbon (AhR) signal transduction pathway and might have adverse effect on humans and wildlife. Group: Brominated Flame Retardant. Alternative Names: BDE 5; PBDE 5. CAS No. 446254-14-4. Product ID: ACM446254144. Molecular formula: C12H8Br2O. Mole weight: 328. | |
1-(3,4-Dichlorophenyl)-3-(thiazol-2-yl)thiourea Quick inquiry Where to buy Suppliers range | It is a thiourea derivative synthesized from 1,3-thiazole. It inhibits biofilm formation in wild type and methicillin-resistant strains of staphylococcus epidermidis. Synonyms: 1-(3,4-Dichlorophenyl)-3-(2-thiazolyl)thiourea. Grades: ≥95%. Molecular formula: C10H7Cl2N3S2. Mole weight: 304.22. | |
1-(3-Chloro-4-fluorophenyl)-3-(thiazol-2-yl)thiourea Quick inquiry Where to buy Suppliers range | It is a halogen-containing thiourea derivative synthesized from 1,3-thiazole. It inhibits biofilm formation in wild type and methicillin-resistant strains of staphylococcus epidermidis. Synonyms: 1-(3-Chloro-4-fluorophenyl)-3-(2-thiazolyl)thiourea. Grades: ≥95%. Molecular formula: C10H7ClFN3S2. Mole weight: 287.76. | |
1,4-Dibromo-2-(2-bromophenoxy)benzene Quick inquiry Where to buy Suppliers range | 1,4-Dibromo-2-(2-bromophenoxy)benzene. Uses: 1,4-Dibromo-2-(2-bromophenoxy)benzene is a polybrominated diphenyl ether that functions as a flame retardant. It is also an environmental contaminant and might activate the aryl hydrocarbon (AhR) signal transduction pathway and might have adverse effect on humans and wildlife. Group: Brominated Flame Retardant. Alternative Names: BDE 18; PBDE 18. CAS No. 407606-55-7. Product ID: ACM407606557. Molecular formula: C12H7Br3O. Mole weight: 406.9. | |
17-AAG hydrochloride Quick inquiry Where to buy Suppliers range | 17-AAG hydrochloride is a potent HSP90 inhibitor with IC50 value of 5 nM, which is a 100-fold higher binding affinity for HSP90 derived from tumour cells than that from normal cells. It is less toxic by binding to Hsp90 and altering its function. It causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor (AR), leading to the RB-dependent G1 growth arrest of prostate cancer cells. It has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant T315I and E255K BCR-ABL mutants with IC50 values of 2.3 μM and 1.0 μM, respectively. It displays significantly higher binding affinity for Hsp90 from 3T3-src, B16 or CT26 xenografts in nude mice compared with that from the normal tissues in vivo. Uses: 17-aag hydrochloride has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant t315i and e255k bcr-abl mutants. Synonyms: 17-AAG hydrochloride; 17 AAG hydrochloride; 17AAG hydrochloride; [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate hydrochloride;Tanespimycin Hydrochloride;NSC 330507 Hydrochloride;CP 127374 Hydrochloride;17-(Allylamino)-17-desmethylgeldanamycin hydrochloride. Grades: >98%. CAS No. 911710-03-7. Molecular formula: C31H44ClN3O8. Mole weight: 622.15. | |
1-Bromo-3-phenoxybenzene Quick inquiry Where to buy Suppliers range | 1-Bromo-3-phenoxybenzene is part of a group of compounds called polybrominated diphenyl ethers. 1-Bromo-3-phenoxybenzene, along with other similar compounds, are widely used in industry as brominated flame retardants. Unfortunately, with their release into the environment, they pose significant hazards to the humans and wildlife that live in surrounding areas. 1-Bromo-3-phenoxybenzene is also known to induce toxic effects on the central nervous system, the liver, and kidneys in rats. Group: Biochemicals. Grades: Highly Purified. CAS No. 6876-00-2. Pack Sizes: 1g, 2.5g. Molecular Formula: C12H9BrO. US Biological Life Sciences. | Worldwide |
1-Bromo-3-phenoxybenzene Quick inquiry Where to buy Suppliers range | 1-Bromo-3-phenoxybenzene. Uses: 1-Bromo-3-phenoxybenzene is part of a group of compounds called polybrominated diphenyl ethers. 1-Bromo-3-phenoxybenzene, along with other similar compounds, are widely used in industry as brominated flame retardants. Unfortunately, with their release into the environment, they pose significant hazards to the humans and wildlife that live in surrounding areas. 1-Bromo-3-phenoxybenzene is also known to induce toxic effects on the central nervous system, the liver, and kidneys in rats. Group: Brominated Flame Retardant. Alternative Names: m-Bromophenyl Phenyl Ether; 1-Bromo-3-phenoxybenzene; 3-Bromodiphenyl Ether; 3-Bromophenyl Phenyl Ether; 3-Phenoxy-1-bromobenzene; 3-Phenoxybromobenzene; 3-Phenoxyphenyl Bromide; BDE 2; NSC 57095; PBDE 2; m-Bromodiphenyl Ether; m-Bromophenoxybenzene; m-Phenoxybromobenzene; m-Phenoxyphenyl Bromide. CAS No. 6876-00-2. Product ID: ACM6876002-1. Molecular formula: C12H9BrO. Mole weight: 249.11. | |
1-Naphthyl PP1 Quick inquiry Where to buy Suppliers range | Selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC50 values are 1.0, 0.6, 0.6, 18 and 22 uM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC50 values are 1.5 vs 1000 nM for I338G v-src and v-src respectively). Group: Biochemicals. Grades: Highly Purified. CAS No. 221243-82-9. Pack Sizes: 10mg, 50mg. Molecular Formula: C19H19N5. US Biological Life Sciences. | Worldwide |
1-NA-PP1 Quick inquiry Where to buy Suppliers range | 1-NA-PP1 is a reversible, cell-permeable inhibitor of Src-family tyrosine kinases that have been mutated, by a single base substitution, to become 'analog sensitive' (as), as compared to the wild-type kinase. Synonyms: 1-(Tert-Butyl)-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 1-Naphthyl PP1. CAS No. 221243-82-9. Molecular formula: C19H19N5. Mole weight: 317.39. | |
1-NM-PP1 Quick inquiry Where to buy Suppliers range | 1-NM-PP1 is a cell permeable inhibitor of kinases that have been mutated, by a single base substitution, to become 'analog sensitive' (as), as compared to the wild-type kinase. 1-NM-PP1 was first developed to optimally inhibit v-Src-as1, with an I338G substitution, preferentially over v-Src (IC50 = 4.2 nM versus 28 μM, respectively). Synonyms: 1NM-PP1; 1NM PP1; 1NMPP1l PP1 analog II. CAS No. 221244-14-0. Molecular formula: C20H21N5. Mole weight: 331.41424. | |
2,2',3',4,6-Pentabromodiphenyl Ether Quick inquiry Where to buy Suppliers range | 2,2',3',4,6-Pentabromodiphenyl Ether. Uses: 2,2',3',4,6-Pentabromodiphenyl Ether is a polybrominated diphenyl ether that functions as a flame retardant. It is also an environmental contaminate and might activate the aryl hydrocarbon (AhR) signal transduction pathway and might have adverse effect on humans and wildlife. Group: Brominated Flame Retardant. Alternative Names: 1,3,5-Tribromo-2-(2,3-dibromophenoxy)benzene; 2,3-Dibromophenyl 2,4,6-tribromophenyl Ether; BDE 98; PBDE 98. CAS No. 38463-82-0. Product ID: ACM38463820. Molecular formula: C12H5Br5O. Mole weight: 564.69. | |
2, 2-Difluoro[1, 1, 2, 2-tetrafluoro-2- (pentafluoroethoxy) ethoxy]acetic Acid Ammonium Salt Quick inquiry Where to buy Suppliers range | 2, 2-Difluoro[1, 1, 2, 2-tetrafluoro-2- (pentafluoroethoxy) ethoxy]acetic Acid Ammonium Salt is used in food contact materials. Also, it is novel per- and polyfluoroalkyl substance which are persistent, bioaccumulative and toxic contaminants that are globally present in the environment, wildlife and humans. Group: Biochemicals. Grades: Highly Purified. CAS No. 908020-52-0. Pack Sizes: 5mg, 10mg. Molecular Formula: C6HF11O4; x(NH3), Molecular Weight: 346.051702999999. US Biological Life Sciences. | Worldwide |
2,3-Dimethoxytoluene Quick inquiry Where to buy Suppliers range | 2,3-Dimethoxytoluene is a volatile flavor compound found is many substances such as boiled buckwheat flour, wild rice grain and tar of hickory wood smoke. Group: Biochemicals. Grades: Highly Purified. CAS No. 4463-33-6. Pack Sizes: 1g, 5g. Molecular Formula: C9H12O2, Molecular Weight: 152.19. US Biological Life Sciences. | Worldwide |
2-[4- (2', 4'-Dichloro-5'-hydroxyphenoxy) phenoxy]propionic Acid Sodium Salt Quick inquiry Where to buy Suppliers range | 2-[4- (2', 4'-Dichloro-5'-hydroxyphenoxy) phenoxy]propionic Acid Sodium Salt, is a Diclofop (D431555) metabolite. Diclofop-methyl is used as the active ingredient in many herbicides that are used to control weed growth in plants such as wheat and wild oats. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C15H11Cl2NaO5. US Biological Life Sciences. | Worldwide |
2,4,6-Tribromophenol Quick inquiry Where to buy Suppliers range | 2,4,6-Tribromophenol a reagent used in industrial synthesis of compounds and pharmaceuticals. It is used in the synthesis of anti-HIV candidates. Identified as a metabolic impurity of industrial chemical runoff in humans and wildlife. Group: Biochemicals. Grades: Highly Purified. CAS No. 118-79-6. Pack Sizes: 1g, 10g, 100g. Molecular Formula: C?H?Br?O. US Biological Life Sciences. | Worldwide |
2-Methylpropyl Ester Benzoic Acid Quick inquiry Where to buy Suppliers range | 2-Methylpropyl Ester Benzoic Acid is an volatile aroma compound found in natural wild cherry wine, litchi ice wine and squid. 2-Methylpropyl Ester Benzoic Acid is also a found as a component in essential oils like Dittrichia graveolens (L.) Greuter, Hypericum rumeliacum Boiss. and Alpinia Officinarum rhizomes. Group: Biochemicals. Grades: Highly Purified. CAS No. 120-50-3. Pack Sizes: 5g, 25g. Molecular Formula: C11H14O2, Molecular Weight: 178.23. US Biological Life Sciences. | Worldwide |
2-Nitro-p-anisidine Quick inquiry Where to buy Suppliers range | Toxic to some wild and domestic birds and mice. Molluscicidal activity. Group: Biochemicals. Alternative Names: 1-Amino-2-nitro-4-methoxybenzene; 2-Nitro-4-methoxyaniline; 2-Nitro-4-methoxybenzenamine; 2-Nitro-p-anisidine; 3-Nitro-4-aminoanisole; 4-Amino-1-methoxy-3-nitrobenzene; 4-Amino-3-nitroanisole; 4-Methoxy-2-nitroaniline; 4-Methoxy-2-nitrobenzenamine; 4-Methoxy-2-nitrohbenzenamine; 4-Methoxy-2-nitrophenylamine; 4-Methoxy-o-nitroaniline; Acco Fast Bordeaux GP salt; Amarthol Fast Bordeaux GP Base; Amarthol Fast Bordeaux GP Salt; Atul Fast Bordeaux GP Base; Azobase NAS; Azoene Fast Bordeaux GP Base; Azoene Fast Bordeaux GP Salt; Azofix Bordeaux GP; Azogene Fast Bordeaux G; Bordeaux Base Ciba IV; Bordeaux Base Irga IV; Bordeaux Base NGP; Bordeaux GP Base; Bordeaux GP Salt; Bordeaux GPS Salt; Bordeaux Salt Ciba IV; Bordeaux Salt NGP; Brentamine Fast Bordeaux GP Base; Daito Bordeaux Base GP; Daito Bordeaux Salt GP; Devol Bordeaux B; Devol Bordeaux GP Salt; Diabase Bordeaux GP; Diasalt Bordeaux GP; Durgasol Bordeaux GP Salt; Fast Bordeaux 3NA Base; Fast Bordeaux Base GP; Fast Bordeaux Base J; Fast Bordeaux GDN; Fast Bordeaux GDN base; Fast Bordeaux GP; Fast Bordeaux GP Base; Fast Bordeaux GP-T Base; Fast Bordeaux Salt GP; Fast Bordeaux Salt GPN; Fast Bordeaux Salt J; Hansol Bordeaux GP Salt; Hiltonil Fast Bordeaux GP Base; Hiltosal Fast Bordeaux GP Salt; Hindasol Bordeaux GP Salt; Kako Bordeaux GP Base; Kako Bordeaux GP Salt; Kayaku Fast Bordeaux GP Base; Kayaku Fast Bordeaux Salt GP; Lake Maroon B base; Mitsui Bordeaux GP Base; Mitsui Bordeaux GP Salt; NSC 5509; Naphthanil Bordeaux GP Base; Naphthanil Diazo Bordeaux GP; Naphthosol Fast Bordeaux GP Salt; Naphtoelan Fast Bordeaux GP Base; Naphtoelan Fast Bordeaux GP Salt; Natasol Bordeaux GP Salt; Pharmasol Bordeaux GP; Pharmazoid Bordeaux GP; Sanyo Fast Bordeaux GP Base; Sanyo Fast Bordeaux Salt GP; Shinnippon Fast Bordeaux GP Base; Sugai Fast Bordeaux GP Base; Symulon Bordeaux GP Base; Tulabase Fast Bordeaux GP; o-Nitro-p-anisidine; p-Methoxy-o-nitroaniline. Grades: Highly Purified. CAS No. 96-96-8. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
2-Nitro-p-anisidine-15N Quick inquiry Where to buy Suppliers range | Labeled 2-Nitro-p-anisidine. Toxic to some wild and domestic birds and mice. Molluscicidal activity. Group: Biochemicals. Alternative Names: 1-Amino-2-nitro-4-methoxybenzene-15N; 2-Nitro-4-methoxyaniline-15N; 2-Nitro-4-methoxybenzenamine-15N; 2-Nitro-p-anisidine-15N; 3-Nitro-4-aminoanisole-15N; 4-Amino-1-methoxy-3-nitrobenzene-15N; 4-Amino-3-nitroanisole-15N; 4-Methoxy-2-nitroaniline-15N; 4-Methoxy-2-nitrobenzenamine-15N; 4-Methoxy-2-nitrohbenzenamine-15N; 4-Methoxy-2-nitrophenylamine-15N; 4-Methoxy-o-nitroaniline-15N; Acco Fast Bordeaux GP Salt-15N; Amarthol Fast Bordeaux GP Base-15N; Amarthol Fast Bordeaux GP Salt-15N; Atul Fast Bordeaux GP Base-15N; Azobase NAS-15N; Azoene Fast Bordeaux GP Base-15N; o-Nitro-p-anisidine-15N; p-Methoxy-o-nitroaniline-15N. Grades: Highly Purified. CAS No. 873990-80-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
(2R,3R)-Viridifloric Acid Quick inquiry Where to buy Suppliers range | (2R,3R)-Viridifloric Acid is an intermediate in the synthesis of (+)-Lycopsamine (L487525), which occurs in pyrrolizidine alkaloid-containing plants, which are the most common poisonous plants affecting livestock, wildlife, and humans. Thye are being known as hepatotoxins and tumorigens. Group: Biochemicals. Grades: Highly Purified. CAS No. 17233-93-1. Pack Sizes: 10mg, 100mg. Molecular Formula: C7H14O4, Molecular Weight: 162.18. US Biological Life Sciences. | Worldwide |
(2R,3R)-Viridifloric Acid-d7 Quick inquiry Where to buy Suppliers range | (2R,3R)-Viridifloric Acid-d7 is the labeled analogue of (2R,3R)-Viridifloric Acid (V673885), an intermediate in the synthesis of (+)-Lycopsamine (L487525), which occurs in pyrrolizidine alkaloid-containing plants, which are the most common poisonous plants affecting livestock, wildlife, and humans. Thye are being known as hepatotoxins and tumorigens. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 2.5mg. Molecular Formula: C7H7D7O4, Molecular Weight: 169.23. US Biological Life Sciences. | Worldwide |
(2S,3S)-Viridifloric Acid Quick inquiry Where to buy Suppliers range | (2S,3S)-Viridifloric Acid is an intermediate in the synthesis of (+)-Lycopsamine (L487525), which occurs in pyrrolizidine alkaloid-containing plants, which are the most common poisonous plants affecting livestock, wildlife, and humans. Thye are being known as hepatotoxins and tumorigens. Group: Biochemicals. Grades: Highly Purified. CAS No. 17132-48-8. Pack Sizes: 10mg, 100mg. Molecular Formula: C7H14O4, Molecular Weight: 162.18. US Biological Life Sciences. | Worldwide |
(2S,3S)-Viridifloric Acid-d7 Quick inquiry Where to buy Suppliers range | (2S,3S)-Viridifloric Acid-d7 is the labeled analogue of (2S,3S)-Viridifloric Acid (V673895), an intermediate in the synthesis of (+)-Lycopsamine (L487525), which occurs in pyrrolizidine alkaloid-containing plants, which are the most common poisonous plants affecting livestock, wildlife, and humans. Thye are being known as hepatotoxins and tumorigens. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 2.5mg. Molecular Formula: C7H7D7O4, Molecular Weight: 169.23. US Biological Life Sciences. | Worldwide |
3,5-Dihydroxybenzoic acid Quick inquiry Where to buy Suppliers range | 3,5-DHBA is a selective agonist of hydroxycarboxylic acid receptor 1 (HCA1/GPR81) (EC50 ~150 μM). It inhibits lipolysis in wild-type mouse adipocytes. 3,5-DHBA can be used as a biomarker of whole grain wheat and rye. Synonyms: Benzoic acid, 3,5-dihydroxy-; α-Resorcylic acid; 5-Carboxyresorcinol; NSC 22948. Grades: ≥95%. CAS No. 99-10-5. Molecular formula: C7H6O4. Mole weight: 154.12. | |
5-Chloro-2-(methylsulfonyl)pyrimidine-4-carboxylic Acid Quick inquiry Where to buy Suppliers range | PK11007 is an antitumor agent that targets and stabilizes wild type and mutant p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. It blocks cell migration and induces apoptosis in various cancer cell lines. Synonyms: 5-chloro-2-methylsulfonyl-4-pyrimidinecarboxylic acid; 5-chloro-2-methylsulfonylpyrimidine-4-carboxylic acid. CAS No. 38275-34-2. Molecular formula: C6H5ClN2O4S. Mole weight: 236.63. | |
6H05 Quick inquiry Where to buy Suppliers range | 6H05 is a selective inhibitor of oncogenic mutant K-Ras(G12C) without affecting wild-type K-Ras. Synonyms: 1-[2- (4-chlorophenyl) sulfanylacetyl]-N-[2-[2- (dimethylamino) ethyldisulfanyl]ethyl]piperidine-4-carboxamide6H051469338-01-9GTPL8023s7330ZINC205778612CS-3429; CS 3429; CS3429BC600592HY-12408; HY 12408; HY124081-{2-[(4-chlorophenyl)sulfanyl]acetyl}-N-(2-{[2-(dimethylamino)ethyl]disulf. CAS No. 1469338-01-9. Molecular formula: C20H30ClN3O2S3. Mole weight: 476.12. | |
A1874 Quick inquiry Where to buy Suppliers range | A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. A1874 (A-1874) is a nutlin-based and BRD4-degrading PROTAC with DC50 of 32 nM (induce BRD4 degradation in cells); A1874 is more effective in inhibiting proliferation of many cancer cell lines with wild type p53 than was a corresponding VHL-utilizing PROTAC with similar potency and efficacy to degrade BRD4; demonstrates synergistic antiproliferative effect via simultaneous degradation of BRD4 and stabilization of p53. Synonyms: A1874; A 1874; A-1874; (2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-N-(4-((1-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-2-oxo-6,9,12-trioxa-3-azatetradecan-14-yl)carbamoyl)-2-methoxyphenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamide. CAS No. 2064292-12-0. Molecular formula: C58H62Cl3F2N9O7S. Mole weight: 1173.59. | |
A 839977 Quick inquiry Where to buy Suppliers range | A-839977 is a novel and selective P2X7 antagonist. It blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors with IC50 values 20, 42 and 150 nM respectively. It also potently blocked agonist-evoked YO-PRO uptake and IL-1beta release from differentiated human THP-1 cells. It also produced robust antihyperalgesia in the CFA model of inflammatory pain in wild-type mice. It has been exhibited to reduce CFA-induced thermal hyperalgesia in a dose-dependent fashion with the ED50 value of 100μmol/kg. Synonyms: 1-(2,3-Dichlorophenyl)-N-[[2-[(pyridin-2-yl)oxy]phenyl]methyl]-1H-tetrazol-5-amine. Grades: >98 %. CAS No. 870061-27-1. Molecular formula: C19H14Cl2N6O. Mole weight: 413.26. | |
AKN-028 Quick inquiry Where to buy Suppliers range | AKN-028, the FLT3/KIT kinase inhibitor, is an orally bioavailable protein tyrosine kinase inhibitor for FMS-related tyrosine kinase 3 (FLT3; STK1) and stem cell factor receptor (SCFR; KIT), with potential antineoplastic activity. FLT3/KIT kinase inhibitor AKN-028 binds to and inhibits both the wild-type and mutated forms of FLT3 and SCFR. This may result in an inhibition of tumor cell proliferation in cancer cell types that overexpress these receptor tyrosine kinases. Synonyms: AKN 028; AKN028; N2-(1H-Indol-5-yl)-6-(pyridin-4-yl)pyrazine-2,3-diamine; 2,3-Pyrazinediamine, N3-1H-indol-5-yl-5-(4-pyridinyl)-; N3-(1H-Indol-5-yl)-5-(4-pyridinyl)-2,3-pyrazinediamine. Grades: ≥95%. CAS No. 1175017-90-9. Molecular formula: C17H14N6. Mole weight: 302.33. | |
Alda 1 Quick inquiry Where to buy Suppliers range | ALDH2 is the activator of both the wild-type ALDH2*1 and the asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2). Uses: Activator of aldehyde dehydrogenase 2 (aldh2). Synonyms: Alda-1; Alda1; Alda 1. N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide. Grades: ≥98%. CAS No. 349438-38-6. Molecular formula: C15H11Cl2NO3. Mole weight: 324.16. | |
ALLO-1 Quick inquiry Where to buy Suppliers range | ALLO-1 is a SMO antagonist that inhibits both wild-type (IC50 = 50 nM) and mutant SMO, including the D473H SMO mutant (IC50s = 300-1000 nM). ALLO-1 is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 through its LC3-interacting region (LIR) motif. This compound binds to the SMO cysteine-rich domain, which is a different mechanism of interaction compared to other known SMO ligands that bind the transmembrane pocket. Synonyms: 3-(4-Chlorophenyl)-5-methyl-1-(phenylmethyl)-2,4-imidazolidinedione. Grades: ≥98%. CAS No. 37468-32-9. Molecular formula: C17H15ClN2O2. Mole weight: 314.8. | |
Antimicrobial peptide THP2 precursor Quick inquiry Where to buy Suppliers range | Antimicrobial peptide THP2 precursor is an antimicrobial peptide produced by Meleagris gallopavo (Wild turkey). It has antibacterial activity. Synonyms: Leu-Phe-Cys-Lys-Arg-Gly-Thr-Cys-His-Phe-Gly-Arg-Cys-Pro-Ser-His-Leu-Ile-Lys-Val. Grades: >98%. | |
AP1903 Quick inquiry Where to buy Suppliers range | AP1903 is a lipid-permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild-type FKBP12 with 1000-fold lower affinity. Synonyms: AP1903; AP 1903; AP-1903; Rimiducid. Grades: 0.98. CAS No. 195514-63-7. Molecular formula: C78H98N4O20. Mole weight: 1411.63. | |
AST-1306 Quick inquiry Where to buy Suppliers range | AST-1306 is a selective irreversible inhibitor of the epidermal growth factor receptor (EGFR) 1 and 2. Studies show that AST-1306 inhibited the enzymatic activities of wild-type EGF) and ErbB2 as well as EGFR resistant mutant in both cell-free and cell-based systems. AST-1306 was more effective in inhibiting tumors with ErbB2-overexpressing cells than EGFR-overexpressing tumor. Group: Biochemicals. Alternative Names: N- [4- [ [3-Chloro-4- [ (3-fluorobenzyl) oxy] phenyl] amino] quinazolin-6-yl] acrylamide; N-[4-[[3-Chloro-4-[ (3-fluorophenyl) methoxy]phenyl]amino]-6-quinazolinyl]-2-propenamide; ALS1306; AST 1306; AST 6. Grades: Highly Purified. CAS No. 897383-62-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
AZ 12216052 Quick inquiry Where to buy Suppliers range | AZ 12216052 is a positive allosteric modulator of mGluR8. It reduced measures of anxiety in wild-type male mice and is used as a therapeutic target for anxiety disorders. Synonyms: AZ 12216052; AZ-12216052; AZ12216052; 2-[[(4-Bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]acetamide. Grades: ≥98% by HPLC. CAS No. 1290628-31-7. Molecular formula: C19H22BrNOS. Mole weight: 392.35. | |
AZ304 Quick inquiry Where to buy Suppliers range | AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits wild type BRAF, V600E mutant BRAF and wild type CRAF, with IC50s of 79 nM, 38 nM and 68 nM, respectively. AZ304 also has significant effect on other kinases, such as p38 with IC50 of 6 nM, CSF1R with IC50 of 35 nM. It shows antitumor activity. Synonyms: AZ-304; AZ 304. Grades: ≥98%. CAS No. 942507-42-8. Molecular formula: C27H25N5O2. Mole weight: 451.52. | |
AZ5104 Quick inquiry Where to buy Suppliers range | AZ5104 is a potent EGFR inhibitor and a derivative of AZD 9291. AZ5104 exhibits reduced selectivity against wild-type EGFR but five-fold potentcy compared to AZD 9291. Synonyms: AZ-5104; AZ 5104; N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxyphenyl]prop-2-enamide. CAS No. 1421373-98-9. Molecular formula: C27H31N7O2. Mole weight: 485.592. | |
AZ 628 Quick inquiry Where to buy Suppliers range | AZ628 is a potent, ATP-competitive inhibitor of Raf kinases (IC50 values are 29, 34 and 105 nM for c-Raf1, B-RafV600E and wild-type B-Raf, respectively). It displays selectivity for Raf kinases over a panel of 150 other kinases and inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 and Fms. Synonyms: AZ628; AZ-628; AZ 628. Grades: >98%. CAS No. 878739-06-1. Molecular formula: C27H25N5O2. Mole weight: 451.52. | |
AZD-9291 Quick inquiry Where to buy Suppliers range | AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors. AZD9291 is highly active in preclinical models and is well tolerated in animal models. AZD 9291 is an irreversible inhibitor of epidermal growth factor receptor (EGFR) sensitizing and T790M resistance mutations (IC50s = 15-17 nM) while sparing the wild-type form of the receptor (IC50 = 480 nM). It binds the related IGF1R and hERG receptors with significantly reduced potency (IC50s = 2.9 and 16.2 μM, respectively). Uses: For research used only. Synonyms: Mereletinib; EGFR inhibitor; AZD9291; AZD 9291. Grades: 98%. CAS No. 1421373-65-0. Molecular formula: C28H33N7O2. Mole weight: 499.61. | |
BAY-293 Quick inquiry Where to buy Suppliers range | BAY-293 is a potent and cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction with IC50 of 21 nM. It shows antiproliferative activity against wild-type KRAS cell lines with IC50 of 1 uM and cell lines with KRASG12C mutation with IC50 of 3 uM by preventing formation of the KRAS-SOS1 complex. It is a valuable chemical probe for future investigations. Synonyms: BAY 293; BAY293; (R)-6,7-dimethoxy-2-methyl-N-(1-(4-(2-((methylamino)methyl)phenyl)thiophen-2-yl)ethyl)quinazolin-4-amine. Grades: ≥98%. CAS No. 2244904-70-7. Molecular formula: C25H28N4O2S. Mole weight: 448.58. | |
BBT594 Quick inquiry Where to buy Suppliers range | BBT594, also called as NVP-BBT594, a dihydroindole compound, originally developed as an inhibitor of wild-type and T315I-mutant BCR-ABL1, and then subsequently was shown to inhibit JAK2 activity (IC50 = 8nM ~ 29nM in murine models). The Type II JAK2 inhibitor NVP-BBT594 also displayed potent inhibition of HCV activity (EC50 < 1.5 mM). BBT594 impairs GDNF-RET signaling, a promising therapeutic target to enhance the sensitivity to aromatase inhibitor (AI) treatment and revert AI resistance in ER+ breast cancer cells. It also impairs GDNF-dependent growth of MCF7-LTED cells. Synonyms: 5-(6-acetamidopyrimidin-4-yl)oxy-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-2,3-dihydroindole-1-carboxamide; BBT-594; BBT-594; BBT-594; NVP-BBT594; NVP BBT594; NVP BBT-594GTPL7584; SCHEMBL12972358; 5-(6-acetamidopyrimidin-4-yl)oxy-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-2,3-dihydroindole-1-carboxamide. CAS No. 882405-89-2. Molecular formula: C28H30F3N7O3. Mole weight: 569.59. | |
Benztropine Mesylate Quick inquiry Where to buy Suppliers range | Benztropine inhibits MTSET-induced inhibition of [3H]WIN binding to Wild-type dopamine transporter with EC50 of 28 μM in concentration-dependent manner. Synonyms: Benztropine Mesylate; Cogentin; Cogentin mesylate; MLS000737056; Benztropine methanesulfonate; NSC42199; ST50997629; Benzotropine mesylate. Grades: >98%. CAS No. 132-17-2. Molecular formula: C21H25NO.CH4SO3. Mole weight: 403.53. | |
Berberine Chloride (Natural Yellow 18, 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium) Quick inquiry Where to buy Suppliers range | An isoquinoline alkaloid that acts as an anticancer agent. It inhibits cell growth and induces apoptosis in a variety of cancer cell lines. It induces the most potent apoptosis in acute lymphoblastic leukemia (ALL) cells with both MDM2 overexpression and a wild-type (wt)-p53, whereas no pro-apoptotic effect was detected in ALL cells that were negative for MDM2 and wt-p53. Group: Biochemicals. Grades: Highly Purified. CAS No. 633-65-8. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
BIMU 8 Quick inquiry Where to buy Suppliers range | BIMU 8 is a potent and selective 5-HT4 receptor full agonist (KD = 77 nM and EC50 = 18 nM for wild type 5-HT4 receptors). Synonyms: BIMU 8; BIMU8; BIMU-8; 2,3-Dihydro-N-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-3-(1-methylethyl)-2-oxo-1H-benzimidazole-1-carboxamide hydrochloride; N-[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-3-propan-2-ylbenzimidazole-1-carboxamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 134296-40-5. Molecular formula: C19H26N4O2.HCl. Mole weight: 378.9. | |
B-Raf inhibitor 1 dihydrochloride Quick inquiry Where to buy Suppliers range | B-Raf inhibitor 1 is an inhibitor of B-Raf kinase with IC50 values of 0.31μM and 0.72μM for cell proliferation, respectively in A375 and HCT116. B-Raf is important in signal transduction and some mutant B-Raf occurs in cancer cells. The most common mutation of these is V600E, which makes B-Raf kinase constitutively active. B-Raf inhibitor 1 belongs to the type IIA inhibitors and binds to the DFG-out ATP-binding site of B-Raf. The selectivity of B-Raf inhibitor 1 is less than of other type inhibitors. Besides mutant B-Raf, it can also inhibit wild type B-Raf and other tyrosine kinase. In cells with wild type B-Raf, B-Raf inhibitor 1 can activate the RAF-MEK-ERK signaling pathway via Raf dimerization. The preclinical toxicity test shows B-Raf inhibitor 1 can induce hyperplasia in a mouse model. Synonyms: 1,5-Isoquinolinediamine, N1-(4-chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, hydrochloride (1:2). Grades: >98%. CAS No. 1191385-19-9. Molecular formula: C26H21Cl3N8. Mole weight: 551.86. | |
BzATP Triethylammonium Salt (2 (3) -O- (4-Benzoylbenzoyl) adenosine-5-triphosphate tri(triethylammonium) Salt, P2X7 Purinergic Receptor Agonist, BZATP, 2 ,3 -O-(4-benzoylbenzoyl)ATP, P2X Purinergic Receptor Agonist, BZATP) Quick inquiry Where to buy Suppliers range | A prototypic P2X7 purinergic receptor agonist that exhibits about 3-fold higher agonistic potency for induction of nucleotide channels than ATP (EC50 = 15uM vs 50uM). Serves as a photo-affinity analog of ATP. Its agonistic activity is significantly reduced in the presence of serum albumin. Can serve as a substrate analog for submitochondrial particle ATPase activity (Km = 940uM). Induces a dose-dependent decrease in wild-type murine neural progenitor cell viability and an increase in caspase-3 activity. These effects are not observed in P2X7-/- mice. Group: Biochemicals. Grades: Highly Purified. CAS No. 112898-15-4. Pack Sizes: 1mg. Molecular Formula: C??H??N?O??P? 3C?H??N. US Biological Life Sciences. | Worldwide |
Camelina Oil (CAS 8001-31-8) Quick inquiry Where to buy Suppliers range | Camelina oil is an edible vegetable oil extracted from the seeds of Camelina sativa, which is a flowering plant in the Brassicaceae family. Also known as gold-of-pleasure, false flax or wild flax, Camelina sativa is primarily grown for its oil-rich seeds. Camelina oil is rich in polyunsaturated fatty acids (PUFAs), including alpha-linolenic acid (ALA), an omega-3 fatty acid that is essential for human health. Camelina oil also contains monounsaturated fatty acids (MUFAs) and saturated fatty acids (SFAs), as well as vitamins E and K. Uses: 1. Food Industry: Camelina oil can be used for cooking and as a salad dressing due to its high smoke point and omega-3 fatty acid content. 2. Cosmetics Industry: It is used as an ingredient in skincare and hair care products due to its moisturizing properties. 3. Pharmaceutical Industry: Camelina oil is being studied for its potential benefits in treating various health conditions like cardiovascular diseases, inflammatory disorders, and cancer. 4. Biodiesel Industry: Camelina oil can be used as a feedstock for producing biodiesel due to its high oil content and low greenhouse gas emissions. 5. Animal Feed Industry: Camelina meal, a byproduct of Camelina oil production, can be used as a high-quality protein source in animal feed. Group: Conditioning Oils. CAS No. 225233-97-6. Product ID: ACM225233976. Appearance: yellowish oil with a slightly nutty aroma and taste. | |
CID 1375606 Quick inquiry Where to buy Suppliers range | CID 1375606 is a surrogate agonist of orphan G protein-coupled receptor GPR27. Promotes recruitment of β-arrestin 2 to chimeric GPR27V2 and wild-type GPR27 in a firefly luciferase complementation assay (pEC50 values are 6.34 and 5.1, respectively). GPR27 is characterized by a high level of conservation among vertebrates and a predominant expression in the central nervous system. In addition, it has recently been linked to insulin secretion. Synonyms: 2,4-Dichloro-N-(phenylcarbamoyl)phenylbenzamide; 2,4-Dichloro-N-(4-(phenylcarbamoyl)phenyl)benzamide. Grades: ≥98% by HPLC. CAS No. 313493-80-0. Molecular formula: C20H14Cl2N2O2. Mole weight: 385.24. | |
CMP8 Quick inquiry Where to buy Suppliers range | CMP8 is a selective ligand for the estrogen receptor, which can bind to the ligand binding domain of the estrogen receptor. The IC50 values of CMP8 for mutant MGERα, MGRERα and wild-type hERα and hERβ are 29 nM, 41 nM, 1100 nM and 2200 nM, respectively. Grades: 98%. CAS No. 851107-28-3. Molecular formula: C33H34ClNO3. Mole weight: 528.1. | |
CP 31398 dihydrochloride Quick inquiry Where to buy Suppliers range | CP 31398 is a p53 stabilizer and could probably restrain the growth of small human tumor xenografts in vivo. CP 31398 is a prototype small molecule that stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. Synonyms: CP31398 dihydrochloride; CP-31398 dihydrochloride; N'-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine dihydrochloride; 1,3-Propanediamine, N3-[2-[2-(4-methoxyphenyl)ethenyl]-4-quinazolinyl]-N1,N1-dimethyl-, hydrochloride (1:2); PZ 0115; N1-(2-(4-methoxystyryl)quinazolin-4-yl)-N3,N3-dimethylpropane-1,3-diamine dihydrochloride. Grades: ≥99% by HPLC. CAS No. 1217195-61-3. Molecular formula: C22H26N4O.2HCl. Mole weight: 435.39. | |
CP-31398 Dihydrochloride Quick inquiry Where to buy Suppliers range | A styrylquinazoline derivative that acts as a p53 stabilizing agent. It not only restores p53 functions in mutant p53-expressing cells but can also significantly increase the protein level and promote the activity of wild-type p53 in multiple human cancer cell lines, leading to cell cycle arrest or apoptosis. CP-31398 enhances the protein levels of wild-type p53 by blockade of ubiquitination and degradation of p53 without interrupting the physical association between p53 and MDM2 in vivo. Group: Biochemicals. Alternative Names: N'-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine Dihydrochloride. Grades: Highly Purified. CAS No. 259199-65-0. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
CP 31398 dihydrochloride hydrate Quick inquiry Where to buy Suppliers range | CP 31398 is a p53 stabilizer and could probably restrain the growth of small human tumor xenografts in vivo. CP 31398 is a prototype small molecule that stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. Synonyms: 1,3-Propanediamine, N3-[2-[2-(4-methoxyphenyl)ethenyl]-4-quinazolinyl]-N1,N1-dimethyl-, hydrochloride, hydrate (1:2:1); CP31398 dihydrochloride hydrate; CP-31398 dihydrochloride hydrate; N'-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine dihydrochloride hydrate; N1-(2-(4-methoxystyryl)quinazolin-4-yl)-N3,N3-dimethylpropane-1,3-diamine dihydrochloride hydrate. Grades: ≥95%. CAS No. 1853109-76-8. Molecular formula: C22H26N4O.2HCl.H2O. Mole weight: 453.41. | |
Crenolanib Quick inquiry Where to buy Suppliers range | Crenolanib is a tyrosine kinase inhibitor that acts by specifically inhibiting the receptor tyrosine kinases PDGFRα and PDGFR β. Crenolanib inhibits the activity of PDGFRα D842V kinase and prevented the phosphorylation of wild type PDGFRα. Crenolanib possesses potential antineoplastic activity. Crenolanib is believed to suppress PDGFR-related signal transduction pathways leading to the inhibition of tumor angiogenesis and tumor cell proliferation. Group: Biochemicals. Alternative Names: 1-[2-[5-[(3-Methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine; ARO 002; CP 868596; [1-[2-[5-(3-Methyloxetan-3-ylmethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-yl]amine. Grades: Highly Purified. CAS No. 670220-88-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
CZC-54252 Quick inquiry Where to buy Suppliers range | Potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) (IC50 values are 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively). Attenuates neuronal injury induced by LRRK2-G2019S mutant activity in primary human neurons (EC50 = 1 nM). Synonyms: CZC-54252; CZC 54252; CZC54252. Grades: >98%. CAS No. 1191911-27-9. Molecular formula: C22H25ClN6O4S. Mole weight: 504.99. | |
Dafadine-A ( (5- ( (2, 6-Dimethylphenoxy) methyl) isoxazol-3-yl) (4- (pyridin-4-yl) piperidin-1-yl) methanone, 4- (1- ( (5- ( (2, 6-Dimethylphenoxy) methyl) -3-isoxazolyl) carbonyl) -4-piperidinyl) pyridine, DAF-9 Cytochrome P450 Inhibitor, Dafadine-A) Quick inquiry Where to buy Suppliers range | A cell-permeable isoxazoloamide compound that specifically inhibits DAF-9 activity in C. elegans (~20uM) without affecting the activity of DAF-12 and sterol- and oxysterol-metabolizing P450s. Reversibly targets the catalytic heme iron of DAF-9 cytochrome p450 and induce a constitutive dauer (Daf-c), distal-tip cell migration (Mig) and protruding vulval (Pvl) phenotypes in wild-type C. elegans (at ~25uM). Also, shown to be one of the most potent inhibitors of CYP27A1, the mammalian ortholog of DAF-9. Robustly promotes dauer formation (non-aging stress-resistant alternative third larval stage) only in wild type C. elegans and extends their life span by about 29%. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
[D-Ala2]-GIP (human) Quick inquiry Where to buy Suppliers range | A highly potent GIP receptor agonist (EC50 = 630 ± 119 pM). Displays equivalent cAMP stimulating properties and improved resistance to enzymatic degradation compared to native GIP in cells expressing wild type GIP receptor. Improves glucose tolerance, insulin release and cognitive function in various animal models of obesity and diabetes. Displays neuroprotective effects in an MPTP model of PD. Synonyms: (D-Ala2)-Gastric Inhibitory Polypeptide (human); H-Tyr-D-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Gln-OH; L-tyrosyl-D-alanyl-L-alpha-glutamyl-glycyl-L-threonyl-L-phenylalanyl-L-isoleucyl-L-seryl-L-alpha-aspartyl-L-tyrosyl-L-seryl-L-isoleucyl-L-alanyl-L-methionyl-L-alpha-aspartyl-L-lysyl-L-isoleucyl-L-histidyl-L-glutaminyl-L-glutaminyl-L-alpha-aspartyl-L-phenylalanyl-L-valyl-L-asparagyl-L-tryptophyl-L-leucyl-L-leucyl-L-alanyl-L-glutaminyl-L-lysyl-glycyl-L-lysyl-L-lysyl-L-asparagyl-L-alpha-aspartyl-L-tryptophyl-L-lysyl-L-histidyl-L-asparagyl-L-isoleucyl-L-threonyl-L-glutamine. Grades: ≥98% by HPLC. CAS No. 444073-04-5. Molecular formula: C226H338N60O66S. Mole weight: 4983.53. | |
Degrasyn Quick inquiry Where to buy Suppliers range | Degrasyn, also known as WP1130, is a small molecule that specifically and rapidly down-regulates both wild-type and mutant Bcr/Abl protein without affecting bcr/abl gene expression in chronic myelogenous leukemia (CML) cells and Hsp90/Hsp70 ratios within the cells. WP1130 was more effective in reducing leukemic versus normal hematopoietic colony formation and strongly inhibited colony formation of cells derived from patients with T315I mutant Bcr/Abl-expressing CML in blast crisis. WP1130 suppressed the growth of K562 heterotransplanted tumors as well as both wild-type Bcr/Abl and T315I mutant Bcr/Abl-expressing BaF/3 cells transplanted into nude mice. WP1130 may be useful in treating CML. MM1: IC50 = 1 μM (human); U-266: IC50 = 1.3 μM (human); USP9X: IC50 = 3 μM (human); UCH-L1: IC50 = 3 μM (human); USP5: IC50 = 3 μM (human) In vitro: a partly selective DUB inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37, which are known to regulate survival protein stability and 26S proteasome function; In vivo: suppressed the growth of K562 heterotransplanted tumors as well as both wild-type Bcr/Abl and T315I mutant Bcr/Abl-expressing BaF/3 cells transplanted into nude mice. Synonyms: (E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylbutyl]prop-2-enamide; 2-cyano-N-(1-phenylbutyl)-3-(6-bromopyridin-2-yl)acrylamide; degrasyn; WP1130; WP 1130; WP-1130; 856243-80-6; WP 1130; WP-1130; (S,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide; CHEMBL1923233; (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylbutyl]-2-propenamide; WP 1130, WP-1130, 856243-80-6; Degrasyn (WP1130); C19H18BrN3O. Grades: ≥ 98.0%. CAS No. 856243-80-6. Molecular formula: C23H25ClN2O4S. Mole weight: 460.97. | |
(Des-Glu22)-Amyloid β-Protein (1-40) Quick inquiry Where to buy Suppliers range | Osaka mutation is the first deletion type mutation found in APP and A&beta. Aβ E22delta mutant is more resistant to degradation of two major Aβ-degrading enzymes, neprilysin and insulin-degrading enzyme. The synthetic mutant Aβ has unusual aggregation properties, with enhanced oligomerization but no fibrillization. It inhibits long-term hippocampal enhancement more effectively than wild-type A&beta. Synonyms: Amyloid β-Protein (1-40) Osaka or Japanese Mutation; H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH. Grades: ≥95%. CAS No. 1678416-36-8. Molecular formula: C189H288N52O55S. Mole weight: 4200.75. | |
Dioscorea Villosa Root Extract Quick inquiry Where to buy Suppliers range | Dioscorea Villosa Root Extract. Uses: Use as antioxidant. Alternative Names: Dioscorea Villosa (Wild Yam) Root Extract. CAS No. 90147-49-2. Product ID: ACM90147492-1. | |
Doravirine Quick inquiry Where to buy Suppliers range | Doravirine is a non-nucleoside reverse transcriptase inhibitor under development of Merck & Co. IC 50 value is 12 nM against the wild type, 21nM against K103N, 31 nM against Y181C, 33nM against K103N/Y181C mutant viruses in vitro. MK-1439 exhibited similar antiviral activities against 10 different HIV-1 subtype viruses. Phase III for the treatment of HIV-1 infections is on-going. Uses: Hiv-1 infections. Synonyms: MK-1439; MK 1439; MK1439; MK-1439-019;3-Chloro-5-((1-((4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile. Grades: 98%. CAS No. 1338225-97-0. Molecular formula: C17H11ClF3N5O3. Mole weight: 425.75. | |
Dovitinib Quick inquiry Where to buy Suppliers range | Dovitinib (TKI258) potently inhibited FLT3, c-KIT, FGFR, VEGFR1/2/3, PDGFRß and CSF-1R with IC50 values of 1, 2, 5, 10, 8, 27, 36 nM respectively. Dovitinib selectively blocked the growth of wild-type (WT) or activated mutant FGFR3-transformed B9 cells and human myeloma cell lines. Dovitinib was an effective treatment in a xenograft mouse model of FGFR3 multiple myeloma. Synonyms: Dovitinib, TKI258; TKI 258;TKI-258; CHIR 265; CHIR265; CHIR-265; RAF-265; RAF 265; RAF265. Grades: > 95%. CAS No. 405169-16-6. Molecular formula: C21H21FN6O. Mole weight: 392.429. | |
DPC-681 Quick inquiry Where to buy Suppliers range | DPC-681, sulfonamide derivatives, is an extremely potent and selective inhibitor of HIV protease. IC90s: wild-type HIV-1=4-40 nM. Synonyms: DPC 681; DPC-681; DPC681; DPH 153893; DPH-153893; DPH153893; (2R)-N-(2-aminoacetyl)-2-[[(2S)-4-[(3-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-[(3-fluorophenyl)methyl]amino]-3,3-dimethylbutanamide284661-68-3AM021737N-((3-Fluorophenyl)methyl)glycyl-N-((1S,2R)-3-(((3-aminophenyl)sulfo. Grades: 99.89%. CAS No. 284661-68-3. Molecular formula: C35H48FN5O5S. Mole weight: 669.857. |