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Extract obtained from Prunus Serotina (Wild Cherry) bark. Contains 20% extract dissolved in water and glycerin. Has toning, moisturizing and soothing properties. Uses: Creams, lotions, tonics and gels. Group: Skin actives. CAS No. 7732-18-5 / 56-81-5 / 8000-44-0 / 84604-07-9 / 122-99-6. Appearance: Light to medium amber liquid, characteristic odor. Catalog: CI-SC-0789.
Wild Cherry Bark Extract
Wild Cherry Bark Extract. Applications: It can effectively inhibit starch decomposition, which is good for losing weight; with the function of protecting spleen and kidney;promoting the ordered split of wbc in mammals. Group: Others. Synonyms: Wild Cherry Bark Extract; Phaseolus vulgaris L. Purity: 5-10:1 By TLC. Appearance: Light yellow fine powder. Storage: 2 years under well storage situation and stored away from direct sun light. Source: Seed. Species: Phaseolus vulgaris L. Wild Cherry Bark Extract; Phaseolus vulgaris L.; plant extract. Pack: 25KG/Drum with double plastic bag of foodstuff inside. Cat No: EXTW-168.
Wild Jujube Extract (Standard)
Wild Jujube (Zizyphus jujuba) is from the Rhamnaceae family, the Wild Jujube seed is the most popular sedative herb which native to Asia, these dried fruits made their way from Asia into Europe during the days of Marco Polo. Applications: Increasing the brains of production of serotonin.anti-convulsant and anti-epileptic action and anti-aging.altering contractions in the upper and lower digestive tract.decreasing ulceration of the stomach. Group: Others. CAS No. Jujuboside A: 55466-04-1Jujuboside B: 55466-05-2. Purity: 2.0% Jujubosides UV. Mole weight: Jujuboside A: 1207.35Jujuboside B: 1045.21. Wild Jujube Extract (Standard); Jujuboside A: 55466-04-1Jujuboside B: 55466-05-2; Jujuboside A: C58H94O26Jujuboside B: C52H84O21. Cat No: EXTW-023.
Wild Jujube Seed (Zizyphus Spinosa) P.E. 4:1
Wild Jujube Seed (Zizyphus Spinosa) P.E. 4:1.
CA, FL & NJ
Wild Lettuce PE 5:1Wild Lettuce P.E. 5:1
Wild Lettuce PE 5:1Wild Lettuce P.E. 5:1.
CA, FL & NJ
Wild-type Deoxycytidine Kinase from Human, recombinant
Deoxycytidine kinase (dCK, EC:2.7.1.74) is required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG), and deoxyadenosine (dA). dCK has a broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents. Group: Enzymes. Synonyms: Human Dck; WT human dCK. Enzyme Commission Number: EC 2.7.1.74. CAS No. 9039-45-6. Purity: >99% (SDS-PAGE). Mole weight: ~31 kDa. Activity: 6 IU/mg protein. Storage: at -80 °C. Form: Liquid. Source: E. coli. Species: Human. Human Dck; dCK-DM; dCK; Deoxycytidine Kinase; EC 2.7.1.74; WT human dCK; wild-type Human Deoxycytidine kinase; wild-type Deoxycytidine kinase. Cat No: NATE-1695.
Wild Yam Extract
Extract obtained from Dioscorea Villosa (Wild Yam) roots. Contains 20% extract dissolved in water and glycerin. Has soothing, calming, and purifying properties. Uses: Cleansers, moisturizers, astringents and toners. Group: Skin actives. CAS No. 7732-18-5 / 56-81-5 / 90147-49-2 / 122-99-6. Appearance: Colorless to yellow liquid, characterisitic odor. Catalog: CI-SC-0924.
Wild Yam Powder
Wild Yam Powder.
CA, FL & NJ
Fish Collagen Powder (Wild)
Fish Collagen Powder (Wild).
CA, FL & NJ
1,2-Dibromo-3-phenoxybenzene
1,2-Dibromo-3-phenoxybenzene is a polybrominated diphenyl ether that functions as a flame retardant. It is also an environmental contaminant and might activate the aryl hydrocarbon (AhR) signal transduction pathway and might have adverse effect on humans and wildlife. Group: Brominated flame retardant. Alternative Names: BDE 5; PBDE 5. CAS No. 446254-14-4. Molecular formula: C12H8Br2O. Mole weight: 328. Catalog: ACM446254144.
1-(3,4-Dichlorophenyl)-3-(thiazol-2-yl)thiourea
It is a thiourea derivative synthesized from 1,3-thiazole. It inhibits biofilm formation in wild type and methicillin-resistant strains of staphylococcus epidermidis. Synonyms: 1-(3,4-Dichlorophenyl)-3-(2-thiazolyl)thiourea. Grades: ≥95%. Molecular formula: C10H7Cl2N3S2. Mole weight: 304.22.
It is a halogen-containing thiourea derivative synthesized from 1,3-thiazole. It inhibits biofilm formation in wild type and methicillin-resistant strains of staphylococcus epidermidis. Synonyms: 1-(3-Chloro-4-fluorophenyl)-3-(2-thiazolyl)thiourea. Grades: ≥95%. Molecular formula: C10H7ClFN3S2. Mole weight: 287.76.
1,4-Dibromo-2-(2-bromophenoxy)benzene
1,4-Dibromo-2-(2-bromophenoxy)benzene is a polybrominated diphenyl ether that functions as a flame retardant. It is also an environmental contaminant and might activate the aryl hydrocarbon (AhR) signal transduction pathway and might have adverse effect on humans and wildlife. Group: Brominated flame retardant. Alternative Names: BDE 18; PBDE 18. CAS No. 407606-55-7. Molecular formula: C12H7Br3O. Mole weight: 406.9. Catalog: ACM407606557.
17-AAG hydrochloride
17-AAG hydrochloride is a potent HSP90 inhibitor with IC50 value of 5 nM, which is a 100-fold higher binding affinity for HSP90 derived from tumour cells than that from normal cells. It is less toxic by binding to Hsp90 and altering its function. It causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor (AR), leading to the RB-dependent G1 growth arrest of prostate cancer cells. It has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant T315I and E255K BCR-ABL mutants with IC50 values of 2.3 μM and 1.0 μM, respectively. It displays significantly higher binding affinity for Hsp90 from 3T3-src, B16 or CT26 xenografts in nude mice compared with that from the normal tissues in vivo. Uses: 17-aag hydrochloride has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant t315i and e255k bcr-abl mutants. Synonyms: 17-AAG hydrochloride; 17 AAG hydrochloride; 17AAG hydrochloride; [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate hydrochloride;Tanespimycin Hydrochloride;NSC 330507 Hydrochloride;CP 127374 Hydrochloride;17-(Allylamino)-17-desmethylgeldanamycin hydrochloride. Grades: >98%. CAS No. 911710-03-7. Molecular formula: C31H44ClN3O8. Mole weight: 622.15.
1-Bromo-3-phenoxybenzene
1-Bromo-3-phenoxybenzene is part of a group of compounds called polybrominated diphenyl ethers. 1-Bromo-3-phenoxybenzene, along with other similar compounds, are widely used in industry as brominated flame retardants. Unfortunately, with their release into the environment, they pose significant hazards to the humans and wildlife that live in surrounding areas. 1-Bromo-3-phenoxybenzene is also known to induce toxic effects on the central nervous system, the liver, and kidneys in rats. Group: Biochemicals. Grades: Highly Purified. CAS No. 6876-00-2. Pack Sizes: 1g, 2.5g. Molecular Formula: C12H9BrO. US Biological Life Sciences.
Worldwide
1-Naphthyl PP1
Selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC50 values are 1.0, 0.6, 0.6, 18 and 22 uM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC50 values are 1.5 vs 1000 nM for I338G v-src and v-src respectively). Group: Biochemicals. Grades: Highly Purified. CAS No. 221243-82-9. Pack Sizes: 10mg, 50mg. Molecular Formula: C19H19N5. US Biological Life Sciences.
Worldwide
1-NA-PP1
1-NA-PP1 is a reversible, cell-permeable inhibitor of Src-family tyrosine kinases that have been mutated, by a single base substitution, to become 'analog sensitive' (as), as compared to the wild-type kinase. Synonyms: 1-(Tert-Butyl)-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 1-Naphthyl PP1. CAS No. 221243-82-9. Molecular formula: C19H19N5. Mole weight: 317.39.
1-NM-PP1
1-NM-PP1 is a cell permeable inhibitor of kinases that have been mutated, by a single base substitution, to become 'analog sensitive' (as), as compared to the wild-type kinase. 1-NM-PP1 was first developed to optimally inhibit v-Src-as1, with an I338G substitution, preferentially over v-Src (IC50 = 4.2 nM versus 28 μM, respectively). Synonyms: 1NM-PP1; 1NM PP1; 1NMPP1l PP1 analog II. CAS No. 221244-14-0. Molecular formula: C20H21N5. Mole weight: 331.41424.
2,2',3',4,6-Pentabromodiphenyl Ether
2,2',3',4,6-Pentabromodiphenyl Ether is a polybrominated diphenyl ether that functions as a flame retardant. It is also an environmental contaminate and might activate the aryl hydrocarbon (AhR) signal transduction pathway and might have adverse effect on humans and wildlife. Group: Brominated flame retardant. Alternative Names: 1,3,5-Tribromo-2-(2,3-dibromophenoxy)benzene; 2,3-Dibromophenyl 2,4,6-tribromophenyl Ether; BDE 98; PBDE 98. CAS No. 38463-82-0. Molecular formula: C12H5Br5O. Mole weight: 564.69. Catalog: ACM38463820.
2, 2-Difluoro[1, 1, 2, 2-tetrafluoro-2- (pentafluoroethoxy) ethoxy]acetic Acid Ammonium Salt
2, 2-Difluoro[1, 1, 2, 2-tetrafluoro-2- (pentafluoroethoxy) ethoxy]acetic Acid Ammonium Salt is used in food contact materials. Also, it is novel per- and polyfluoroalkyl substance which are persistent, bioaccumulative and toxic contaminants that are globally present in the environment, wildlife and humans. Group: Biochemicals. Grades: Highly Purified. CAS No. 908020-52-0. Pack Sizes: 5mg, 10mg. Molecular Formula: C6HF11O4; x(NH3), Molecular Weight: 346.051702999999. US Biological Life Sciences.
Worldwide
2,3-Dimethoxytoluene
2,3-Dimethoxytoluene is a volatile flavor compound found is many substances such as boiled buckwheat flour, wild rice grain and tar of hickory wood smoke. Group: Biochemicals. Grades: Highly Purified. CAS No. 4463-33-6. Pack Sizes: 1g, 5g. Molecular Formula: C9H12O2, Molecular Weight: 152.19. US Biological Life Sciences.
Worldwide
2-[4- (2', 4'-Dichloro-5'-hydroxyphenoxy) phenoxy]propionic Acid Sodium Salt
2-[4- (2', 4'-Dichloro-5'-hydroxyphenoxy) phenoxy]propionic Acid Sodium Salt, is a Diclofop (D431555) metabolite. Diclofop-methyl is used as the active ingredient in many herbicides that are used to control weed growth in plants such as wheat and wild oats. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C15H11Cl2NaO5. US Biological Life Sciences.
Worldwide
2,4,6-Tribromophenol
2,4,6-Tribromophenol a reagent used in industrial synthesis of compounds and pharmaceuticals. It is used in the synthesis of anti-HIV candidates. Identified as a metabolic impurity of industrial chemical runoff in humans and wildlife. Group: Biochemicals. Grades: Highly Purified. CAS No. 118-79-6. Pack Sizes: 1g, 10g, 100g. Molecular Formula: C?H?Br?O. US Biological Life Sciences.
Worldwide
2-Methylpropyl Ester Benzoic Acid
2-Methylpropyl Ester Benzoic Acid is an volatile aroma compound found in natural wild cherry wine, litchi ice wine and squid. 2-Methylpropyl Ester Benzoic Acid is also a found as a component in essential oils like Dittrichia graveolens (L.) Greuter, Hypericum rumeliacum Boiss. and Alpinia Officinarum rhizomes. Group: Biochemicals. Grades: Highly Purified. CAS No. 120-50-3. Pack Sizes: 5g, 25g. Molecular Formula: C11H14O2, Molecular Weight: 178.23. US Biological Life Sciences.
Worldwide
2-Nitro-p-anisidine
Toxic to some wild and domestic birds and mice. Molluscicidal activity. Group: Biochemicals. Alternative Names: 1-Amino-2-nitro-4-methoxybenzene; 2-Nitro-4-methoxyaniline; 2-Nitro-4-methoxybenzenamine; 2-Nitro-p-anisidine; 3-Nitro-4-aminoanisole; 4-Amino-1-methoxy-3-nitrobenzene; 4-Amino-3-nitroanisole; 4-Methoxy-2-nitroaniline; 4-Methoxy-2-nitrobenzenamine; 4-Methoxy-2-nitrohbenzenamine; 4-Methoxy-2-nitrophenylamine; 4-Methoxy-o-nitroaniline; Acco Fast Bordeaux GP salt; Amarthol Fast Bordeaux GP Base; Amarthol Fast Bordeaux GP Salt; Atul Fast Bordeaux GP Base; Azobase NAS; Azoene Fast Bordeaux GP Base; Azoene Fast Bordeaux GP Salt; Azofix Bordeaux GP; Azogene Fast Bordeaux G; Bordeaux Base Ciba IV; Bordeaux Base Irga IV; Bordeaux Base NGP; Bordeaux GP Base; Bordeaux GP Salt; Bordeaux GPS Salt; Bordeaux Salt Ciba IV; Bordeaux Salt NGP; Brentamine Fast Bordeaux GP Base; Daito Bordeaux Base GP; Daito Bordeaux Salt GP; Devol Bordeaux B; Devol Bordeaux GP Salt; Diabase Bordeaux GP; Diasalt Bordeaux GP; Durgasol Bordeaux GP Salt; Fast Bordeaux 3NA Base; Fast Bordeaux Base GP; Fast Bordeaux Base J; Fast Bordeaux GDN; Fast Bordeaux GDN base; Fast Bordeaux GP; Fast Bordeaux GP Base; Fast Bordeaux GP-T Base; Fast Bordeaux Salt GP; Fast Bordeaux Salt GPN; Fast Bordeaux Salt J; Ha. Grades: Highly Purified. CAS No. 96-96-8. Pack Sizes: 250mg. US Biological Life Sciences.
Worldwide
2-Nitro-p-anisidine-15N
Labeled 2-Nitro-p-anisidine. Toxic to some wild and domestic birds and mice. Molluscicidal activity. Group: Biochemicals. Alternative Names: 1-Amino-2-nitro-4-methoxybenzene-15N; 2-Nitro-4-methoxyaniline-15N; 2-Nitro-4-methoxybenzenamine-15N; 2-Nitro-p-anisidine-15N; 3-Nitro-4-aminoanisole-15N; 4-Amino-1-methoxy-3-nitrobenzene-15N; 4-Amino-3-nitroanisole-15N; 4-Methoxy-2-nitroaniline-15N; 4-Methoxy-2-nitrobenzenamine-15N; 4-Methoxy-2-nitrohbenzenamine-15N; 4-Methoxy-2-nitrophenylamine-15N; 4-Methoxy-o-nitroaniline-15N; Acco Fast Bordeaux GP Salt-15N; Amarthol Fast Bordeaux GP Base-15N; Amarthol Fast Bordeaux GP Salt-15N; Atul Fast Bordeaux GP Base-15N; Azobase NAS-15N; Azoene Fast Bordeaux GP Base-15N; o-Nitro-p-anisidine-15N; p-Methoxy-o-nitroaniline-15N. Grades: Highly Purified. CAS No. 873990-80-8. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
(2R,3R)-Viridifloric Acid
(2R,3R)-Viridifloric Acid is an intermediate in the synthesis of (+)-Lycopsamine (L487525), which occurs in pyrrolizidine alkaloid-containing plants, which are the most common poisonous plants affecting livestock, wildlife, and humans. Thye are being known as hepatotoxins and tumorigens. Group: Biochemicals. Grades: Highly Purified. CAS No. 17233-93-1. Pack Sizes: 10mg, 100mg. Molecular Formula: C7H14O4, Molecular Weight: 162.18. US Biological Life Sciences.
Worldwide
(2R,3R)-Viridifloric Acid-d7
(2R,3R)-Viridifloric Acid-d7 is the labeled analogue of (2R,3R)-Viridifloric Acid (V673885), an intermediate in the synthesis of (+)-Lycopsamine (L487525), which occurs in pyrrolizidine alkaloid-containing plants, which are the most common poisonous plants affecting livestock, wildlife, and humans. Thye are being known as hepatotoxins and tumorigens. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 2.5mg. Molecular Formula: C7H7D7O4, Molecular Weight: 169.23. US Biological Life Sciences.
Worldwide
(2S,3S)-Viridifloric Acid
(2S,3S)-Viridifloric Acid is an intermediate in the synthesis of (+)-Lycopsamine (L487525), which occurs in pyrrolizidine alkaloid-containing plants, which are the most common poisonous plants affecting livestock, wildlife, and humans. Thye are being known as hepatotoxins and tumorigens. Group: Biochemicals. Grades: Highly Purified. CAS No. 17132-48-8. Pack Sizes: 10mg, 100mg. Molecular Formula: C7H14O4, Molecular Weight: 162.18. US Biological Life Sciences.
Worldwide
(2S,3S)-Viridifloric Acid-d7
(2S,3S)-Viridifloric Acid-d7 is the labeled analogue of (2S,3S)-Viridifloric Acid (V673895), an intermediate in the synthesis of (+)-Lycopsamine (L487525), which occurs in pyrrolizidine alkaloid-containing plants, which are the most common poisonous plants affecting livestock, wildlife, and humans. Thye are being known as hepatotoxins and tumorigens. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 2.5mg. Molecular Formula: C7H7D7O4, Molecular Weight: 169.23. US Biological Life Sciences.
Worldwide
2-Tridecanone
2-Tridecanone, a nonalkaloid insecticide, is isolated from the wild tomato Lycopersicon hirsutum f. glabratum. 2-Tridecanone is a volatile organic compound [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 593-08-8. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-W009811.
(2Z,6Z)-farnesyl diphosphate synthase
This enzyme, originally characterized from wild tomato, specifically forms (2Z,6Z)-farnesyl diphosphate via neryl diphosphate and isopentenyl diphosphate. In wild tomato it is involved in the biosynthesis of several sesquiterpenes. See also EC 2.5.1.68 [(2Z,6E)-farnesyl diphosphate synthase] and EC 2.5.1.10 [(2E,6E)-farnesyl diphosphate synthase]. Group: Enzymes. Synonyms: cis,cis-farnesyl diphosphate synthase; Z,Z-FPP synthase; zFPS; Z,Z-farnesyl pyrophosphate synthase. Enzyme Commission Number: EC 2.5.1.92. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2831; (2Z,6Z)-farnesyl diphosphate synthase; EC 2.5.1.92; cis,cis-farnesyl diphosphate synthase; Z,Z-FPP synthase; zFPS; Z,Z-farnesyl pyrophosphate synthase. Cat No: EXWM-2831.
3,5-Dihydroxybenzoic acid
3,5-DHBA is a selective agonist of hydroxycarboxylic acid receptor 1 (HCA1/GPR81) (EC50 ~150 μM). It inhibits lipolysis in wild-type mouse adipocytes. 3,5-DHBA can be used as a biomarker of whole grain wheat and rye. Synonyms: Benzoic acid, 3,5-dihydroxy-; α-Resorcylic acid; 5-Carboxyresorcinol; NSC 22948. Grades: ≥95%. CAS No. 99-10-5. Molecular formula: C7H6O4. Mole weight: 154.12.
4,6-O-Ethylidene-α-D-glucose
4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose), a glucose derivative, is a competitive exofacial binding-site inhibitor on glucose transporter 1 (GLUT1) with a K i of 12 mM for wild-type 2-deoxy-D-glucose transport [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Ethylidene-glucose. CAS No. 13224-99-2. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-N7433.
4'-Methylacetophenone
4-methylacetophenone can be used as a fragrance material. 4-Methylacetophenone is wildly occurs in volatile compounds in food and in some natural complex substances (NCS) [1]. Uses: Scientific research. Group: Natural products. CAS No. 122-00-9. Pack Sizes: 10 mM * 1 mL; 25 g; 100 g. Product ID: HY-W012653.
4-Vinylphenol (10% in Propylene glycol)
4-Vinylphenol is found in the medicinal herb Hedyotis diffusa Willd, wild rice and is also the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine. 4-Vinylphenol induces apoptosis and inhibits blood vessels formation and suppresses invasive breast tumor growth in vivo [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 4-Hydroxystyrene. CAS No. 2628-17-3. Pack Sizes: 100 mg (832.2 mM * 1 mL in Propylene glycol). Product ID: HY-W005288.
PK11007 is an antitumor agent that targets and stabilizes wild type and mutant p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. It blocks cell migration and induces apoptosis in various cancer cell lines. Synonyms: 5-chloro-2-methylsulfonyl-4-pyrimidinecarboxylic acid; 5-chloro-2-methylsulfonylpyrimidine-4-carboxylic acid. CAS No. 38275-34-2. Molecular formula: C6H5ClN2O4S. Mole weight: 236.63.
6H05
6H05 is a selective inhibitor of oncogenic mutant K-Ras(G12C) without affecting wild-type K-Ras. Synonyms: 1-[2- (4-chlorophenyl) sulfanylacetyl]-N-[2-[2- (dimethylamino) ethyldisulfanyl]ethyl]piperidine-4-carboxamide6H051469338-01-9GTPL8023s7330ZINC205778612CS-3429; CS 3429; CS3429BC600592HY-12408; HY 12408; HY124081-{2-[(4-chlorophenyl)sulfanyl]acetyl}-N-(2-{[2-(dimethylamino)ethyl]disulf. CAS No. 1469338-01-9. Molecular formula: C20H30ClN3O2S3. Mole weight: 476.12.
A1874
A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. A1874 (A-1874) is a nutlin-based and BRD4-degrading PROTAC with DC50 of 32 nM (induce BRD4 degradation in cells); A1874 is more effective in inhibiting proliferation of many cancer cell lines with wild type p53 than was a corresponding VHL-utilizing PROTAC with similar potency and efficacy to degrade BRD4; demonstrates synergistic antiproliferative effect via simultaneous degradation of BRD4 and stabilization of p53. Synonyms: A1874; A 1874; A-1874; (2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-N-(4-((1-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-2-oxo-6,9,12-trioxa-3-azatetradecan-14-yl)carbamoyl)-2-methoxyphenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamide. CAS No. 2064292-12-0. Molecular formula: C58H62Cl3F2N9O7S. Mole weight: 1173.59.
A 839977
A-839977 is a novel and selective P2X7 antagonist. It blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors with IC50 values 20, 42 and 150 nM respectively. It also potently blocked agonist-evoked YO-PRO uptake and IL-1beta release from differentiated human THP-1 cells. It also produced robust antihyperalgesia in the CFA model of inflammatory pain in wild-type mice. It has been exhibited to reduce CFA-induced thermal hyperalgesia in a dose-dependent fashion with the ED50 value of 100μmol/kg. Synonyms: 1-(2,3-Dichlorophenyl)-N-[[2-[(pyridin-2-yl)oxy]phenyl]methyl]-1H-tetrazol-5-amine. Grades: >98 %. CAS No. 870061-27-1. Molecular formula: C19H14Cl2N6O. Mole weight: 413.26.
ABT-100
ABT-100 is an orally bioavailable farnesyltransferase inhibitor. ABT-100 inhibited proliferation of cells in vitro carrying oncogenic H-Ras (EJ-1 bladder; IC(50) 2.2 nmol/L), Ki-Ras (DLD-1 colon, MDA-MB-231 breast, HCT-116 colon, and MiaPaCa-2 pancreatic; IC(50) range, 3.8-9.2 nmol/L), and wild-type Ras (PC-3 and DU-145; IC(50), 70 and 818 nmol/L, respectively) as well as clonogenic potential. ABT-100 shows 70% to 80% oral bioavailability in mice. ABT-100 regressed EJ-1 tumors (2-12.5 mg/kg/d s.c., every day for 21 days) and showed significant efficacy in DLD-1, LX-1, MiaPaCa-2, or PC-3 tumor-bearing mice (6.25-50 mg/kg/d s.c. once daily or twice daily orally). Group: Inhibitors. Alternative Names: ABT100; ABT 100; ABT-100; A367074; A 367074; A-367074. CAS No. 450839-40-4. Molecular formula: C27H19F3N4O3. Mole weight: 504.46. Appearance: White solid powder. Purity: >98%. IUPACName: (S)-6-(2-(4-cyanophenyl)-2-hydroxy-2-(1-methyl-1H-imidazol-5-yl)ethoxy)-4'-(trifluoromethoxy)-[1, 1'-biphenyl]-3-carbonitrile. Canonical SMILES: N#CC1=CC (C2=CC=C (OC (F) (F)F)C=C2)=C (OC[C@] (O) (C3=CC=C (C#N)C=C3)C4=CN=CN4C)C=C1. Catalog: ACM450839404.
Adefovir dipivoxil
Adefovir dipivoxil, an adenosine analogue, is an oral proagent of the nucleoside reverse transcriptase inhibitor Adefovir. Adefovir dipivoxil inhibits both the wild type and HBV Lamivudine-resistant strains [1] [2]. Adefovir dipivoxil shows anti-orthopoxvirus activity. Uses: Scientific research. Group: Natural products. Alternative Names: GS 0840. CAS No. 142340-99-6. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 500 mg. Product ID: HY-B0255.
Adefovir dipivoxil
Adefovir dipivoxil, an adenosine analogue, is an oral proagent of the nucleoside reverse transcriptase inhibitor Adefovir. Adefovir dipivoxil inhibits both the wild type and HBV Lamivudine-resistant strains. Adefovir dipivoxil shows anti-orthopoxvirus activity. Group: Inhibitors. Alternative Names: BIS POM PMEA; BIS (PIVALOYLOXYMETHYL) -9- [2- (PHOSPHONOMETHOXY) ETHYL] ADENINE; 9- [2- [bis [ (pivaloyloxy) methoxy] phosphinyl] methoxy] ethyl] adenine; ADEFOVIR DIPIVOXIL;ADEFOVIR PIVOXIL;Adefovir Dipivoxyl;Bis(Pivaloyloxymethyl)-9-[(R)-2-(Phosphonomethoxy)Ethyl]Adenine ;AdefovirDipivoxl98.5%Min. CAS No. 142340-99-6. Molecular formula: C20H32N5O8P. Mole weight: 501.47. Appearance: Solid. Purity: 0.9999. Canonical SMILES: NC1=C2N=CN (CCOCP (OCOC (C (C) (C)C)=O) (OCOC (C (C) (C)C)=O)=O)C2=NC=N1. Catalog: ACM142340996.
AKN-028
AKN-028, the FLT3/KIT kinase inhibitor, is an orally bioavailable protein tyrosine kinase inhibitor for FMS-related tyrosine kinase 3 (FLT3; STK1) and stem cell factor receptor (SCFR; KIT), with potential antineoplastic activity. FLT3/KIT kinase inhibitor AKN-028 binds to and inhibits both the wild-type and mutated forms of FLT3 and SCFR. This may result in an inhibition of tumor cell proliferation in cancer cell types that overexpress these receptor tyrosine kinases. Synonyms: AKN 028; AKN028; N2-(1H-Indol-5-yl)-6-(pyridin-4-yl)pyrazine-2,3-diamine; 2,3-Pyrazinediamine, N3-1H-indol-5-yl-5-(4-pyridinyl)-; N3-(1H-Indol-5-yl)-5-(4-pyridinyl)-2,3-pyrazinediamine. Grades: ≥95%. CAS No. 1175017-90-9. Molecular formula: C17H14N6. Mole weight: 302.33.
Alamifovir
Alamifovir (LY582563; MCC-478), a purine nucleotide analogue proagent, shows potent activity against wild type and lamivudine resistant hepatitis B virus (HBV). Alamifovir has high activity against HBV replication and sustained antiviral effect [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY582563; MCC-478. CAS No. 193681-12-8. Pack Sizes: 1 mg. Product ID: HY-119691.
Alamifovir
Alamifovir (LY582563; MCC-478), a purine nucleotide analogue proagent, shows potent activity against wild type and lamivudine resistant hepatitis B virus (HBV). Alamifovir has high activity against HBV replication and sustained antiviral effect. Group: Inhibitors. Alternative Names: alamifovir. CAS No. 193681-12-8. Molecular formula: C19H20F6N5O5PS. Mole weight: 575.425. Purity: 0.96. IUPACName: 9-[2-[bis (2, 2, 2-trifluoroethoxy) phosphorylmethoxy]ethyl]-6-phenylsulfanylpurin-2-amine. Canonical SMILES: COC1=CC=C (C=C1)SC2=C3N=CN (C3=NC (N)=N2)CCOCP (OCC (F) (F)F) (OCC (F) (F)F)=O. Density: 1.61g/cm³. Catalog: ACM193681128.
Alda 1
ALDH2 is the activator of both the wild-type ALDH2*1 and the asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2). Uses: Activator of aldehyde dehydrogenase 2 (aldh2). Synonyms: Alda-1; Alda1; Alda 1. N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide. Grades: ≥98%. CAS No. 349438-38-6. Molecular formula: C15H11Cl2NO3. Mole weight: 324.16.
Alda-1
Alda-1 is a potent and selective ALDH2 agonist, which activates wild-type ALDH2 and restores near wild-type activity to ALDH2*2. Uses: Scientific research. Group: Signaling pathways. CAS No. 349438-38-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-18936.
ALLO-1
ALLO-1 is a SMO antagonist that inhibits both wild-type (IC50 = 50 nM) and mutant SMO, including the D473H SMO mutant (IC50s = 300-1000 nM). ALLO-1 is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 through its LC3-interacting region (LIR) motif. This compound binds to the SMO cysteine-rich domain, which is a different mechanism of interaction compared to other known SMO ligands that bind the transmembrane pocket. Synonyms: 3-(4-Chlorophenyl)-5-methyl-1-(phenylmethyl)-2,4-imidazolidinedione. Grades: ≥98%. CAS No. 37468-32-9. Molecular formula: C17H15ClN2O2. Mole weight: 314.8.
Almonertinib
Almonertinib (HS-10296) is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 ( IC 50 : 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib is used for the research of the non-small cell lung cancer [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HS-10296. CAS No. 1899921-05-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112823.
Almonertinib hydrochloride
Almonertinib (HS-10296) hydrochloride is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib hydrochloride shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 ( IC 50 : 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib hydrochloride is used for the research of the non-small cell lung cancer [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HS-10296 hydrochloride. CAS No. 2134096-03-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112823B.
Almonertinib mesylate
Almonertinib (HS-10296) mesylate is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib mesylate shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 ( IC 50 : 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib mesylate is used for the research of the non-small cell lung cancer [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HS-10296 mesylate. CAS No. 2134096-06-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112823A.
Aloe vera powder
Aloe vera, sometimes described as a "wonder plant", is a short-stemmed shrub that only occurs in cultivation - it cannot be found in the wild. Some related Aloes occur naturally in North Africa. An Aloe is a genus containing more than 500 species of flowering succulent plants.The Aloe vera leaves are succulent, erect and form a dense rosette. Many uses are made from the gel obtained from the plant's leaves. Applications: 1.food additives, beverages canned food, dairy products, etc.2.health articles: tablets, capsules, oral liquid tonic, medicine to be taken after being mixed with boiling water, wine, etc. and other health articles of does type with associative efficiency. household and personal care chemicals: cosmetics of suntan, fleck and acne dispelling, hand and skin care; products of skin cleaning, moisture and other products such as liquid shampoo, hair conditioner, bath foam, hair waving chemical, shaving chemical,depilate chemical, etc.3.drugs:anti-cancer drugs, traditional anodyne, spray set of emergency treatment, hemorrhoids curing, scar ispelling, etc.4. sanitary accessories?diaper, napkin, disinfectant, liquid soap, etc. Group: Others. Purity: 100:1, 200:1. Appearance: Off -white powder. Aloe vera powder; Aloe barbadensis Miller. Cat No: EXTC-159.
α-Lytic Protease M190A Mutant, Recombinant
Alpha-lytic protease (aLP) is an alternative specificity protease for proteomics applications, whose wild-type (WT) version cleaves after T, A, S, and V residues. The M190A (Met190 ? Ala190) mutant of aLP has different cleavage specificities, and cleaves after M, F, and L residues. Both the WT and M190A forms of aLP geneRate peptides of similar average length as trypsin. Group: Enzymes. Synonyms: ALP M190A; Alpha-Lytic Protease M190A Mutant. ALP M190A. Activity: > 0.05 U/mg. Storage: -70°C. ALP M190A; Alpha-Lytic Protease M190A Mutant. Cat No: NATE-0051.
American ginseng extract
American ginseng extract. Applications: Applied in the food field, applied in the health product field;applied in the pharmaceutical field. Group: Others. Purity: 10%-80% Ginsenosideds UV. Appearance: Brown yellow powder. Source: American ginseng (Panax quinquefolius) is a herbaceous perennial plant in the ivy family. American ginseng was formerly particularly widespread in the Appalachian and Ozark regions (and adjacent forested regions such as Pennsylvania, New York and Ontario). It is also grown commercially, under artificial shade, woods cultivated, or wild-simulated methods, in Wisconsin and Minnesota. Wisconsin, particularly Marathon County, accounts for about 95% of production in the United States. It is also widely grown in Ontario, Canada and China. American ginseng extract. Cat No: EXTC-171.
AMG-193
AMG 193 is an orally active MTA-cooperative PRMT5 inhibitor with antitumor activity. AMG 193, when complexed with MTA, preferentially inhibits the growth of MTAP-deficient tumor cells by inhibiting PRMT5 ( IC 50 =0.107 μM), thereby protecting normal cells with wild-type MTAP [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2790567-82-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153390.
Antimicrobial peptide THP2 precursor
Antimicrobial peptide THP2 precursor is an antimicrobial peptide produced by Meleagris gallopavo (Wild turkey). It has antibacterial activity. Synonyms: Leu-Phe-Cys-Lys-Arg-Gly-Thr-Cys-His-Phe-Gly-Arg-Cys-Pro-Ser-His-Leu-Ile-Lys-Val. Grades: >98%.
AP1903
AP1903 is a lipid-permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild-type FKBP12 with 1000-fold lower affinity. Synonyms: AP1903; AP 1903; AP-1903; Rimiducid. Grades: 0.98. CAS No. 195514-63-7. Molecular formula: C78H98N4O20. Mole weight: 1411.63.
AST-1306
AST-1306 is a selective irreversible inhibitor of the epidermal growth factor receptor (EGFR) 1 and 2. Studies show that AST-1306 inhibited the enzymatic activities of wild-type EGF) and ErbB2 as well as EGFR resistant mutant in both cell-free and cell-based systems. AST-1306 was more effective in inhibiting tumors with ErbB2-overexpressing cells than EGFR-overexpressing tumor. Group: Biochemicals. Alternative Names: N- [4- [ [3-Chloro-4- [ (3-fluorobenzyl) oxy] phenyl] amino] quinazolin-6-yl] acrylamide; N-[4-[[3-Chloro-4-[ (3-fluorophenyl) methoxy]phenyl]amino]-6-quinazolinyl]-2-propenamide; ALS1306; AST 1306; AST 6. Grades: Highly Purified. CAS No. 897383-62-9. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Astaxanthin
Astaxanthin. Synonyms: 3,3'-DIHYDROXY-B,B-CAROTENE-4,4'-DIONE;3,3-DIHYDROXY-B,B-CAROTENE-4,4-DIONE;3,3'-DIHYDROXY-BETA,BETA-CAROTENE-4,4'-DIONE;ASTAXANTHIN;AXN;Astazine 5%;(3S,3S)-3,3-Dihydroxy-.beta.. beta.-carotene-4,4-dione;HAEMATOCOCCUS PLUVIALIS. CAS No. 472-61-7. Pack Sizes: 1 kg. Product ID: CDF4-0145. Molecular formula: C40H52O4. Category: Nutrients. Product Keywords: Food Ingredients; Nutrients; Astaxanthin; CDF4-0145; 472-61-7; C40H52O4; 207-451-4; 472-61-7. Purity: 0.99. Color: pink to very dark purple. EC Number: 207-451-4. Physical State: Powder. Solubility: DMSO: soluble1mg/mL (warmed). Storage: -20°C. Boiling Point: 568.55°C (rough estimate). Melting Point: 215-216 °C. Density: 0.9980 (rough estimate). Product Description: all-trans-Astaxanthin is a ketocarotenoid, most commonly identified in marine and aquatic animals, including krill, wild salmon, rainbow trout, microalgae, shells of lobster, shrimp, seafood products, etc. It is biologically known as a vitamin A precursor, and exhibits strong antioxidant property, much higher compared to vitamin E and β-carotene. Its role in food and the medicinal industry is also well-defined.
Avitinib
Avitinib (Abivertinib) is a third-generation, irreversible and orally active selective EGFR inhibitor, with IC 50 values of 0.18 nM, 0.18 nM, 7.68 nM and against EGFR L858R , EGFR T790M and wild-type EGFR. Avitinib is also a BTK inhibitor that induces apoptosis and inhibits phosphorylation of BTK in mantle cell lymphoma. Avitinib shows anticancer effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Abivertinib; AC0010. CAS No. 1557267-42-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-19816.
Avitinib maleate
Avitinib (Abivertinib) maleate is a third-generation, irreversible and orally active selective EGFR inhibitor, with IC 50 values of 0.18 nM, 0.18 nM, 7.68 nM and against EGFR L858R , EGFR T790M and wild-type EGFR. Avitinib maleate is also a BTK inhibitor that induces apoptosis and inhibits phosphorylation of BTK in mantle cell lymphoma. Avitinib maleate shows anticancer effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Abivertinib maleate; AC0010 maleate. CAS No. 1557268-88-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19816A.
AZ 12216052
AZ 12216052 is a positive allosteric modulator of mGluR8. It reduced measures of anxiety in wild-type male mice and is used as a therapeutic target for anxiety disorders. Synonyms: AZ 12216052; AZ-12216052; AZ12216052; 2-[[(4-Bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]acetamide. Grades: ≥98% by HPLC. CAS No. 1290628-31-7. Molecular formula: C19H22BrNOS. Mole weight: 392.35.
AZ304
AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits wild type BRAF, V600E mutant BRAF and wild type CRAF, with IC 50 s of 79 nM, 38 nM and 68 nM, respectively. AZ304 also has significant effect on other kinases, such as p38 ( IC 50 , 6 nM), CSF1R ( IC 50 , 35 nM). Anti-tumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 942507-42-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117273.
AZ304
AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits wild type BRAF, V600E mutant BRAF and wild type CRAF, with IC50s of 79 nM, 38 nM and 68 nM, respectively. AZ304 also has significant effect on other kinases, such as p38 with IC50 of 6 nM, CSF1R with IC50 of 35 nM. It shows antitumor activity. Synonyms: AZ-304; AZ 304. Grades: ≥98%. CAS No. 942507-42-8. Molecular formula: C27H25N5O2. Mole weight: 451.52.
AZ5104
AZ5104 is a potent EGFR inhibitor and a derivative of AZD 9291. AZ5104 exhibits reduced selectivity against wild-type EGFR but five-fold potentcy compared to AZD 9291. Synonyms: AZ-5104; AZ 5104; N-[2-[2-(dimethylamino)ethyl-methylamino]-5-[[4-(1H-indol-3-yl)pyrimidin-2-yl]amino]-4-methoxyphenyl]prop-2-enamide. CAS No. 1421373-98-9. Molecular formula: C27H31N7O2. Mole weight: 485.592.
AZ 628
AZ628 is a potent, ATP-competitive inhibitor of Raf kinases (IC50 values are 29, 34 and 105 nM for c-Raf1, B-RafV600E and wild-type B-Raf, respectively). It displays selectivity for Raf kinases over a panel of 150 other kinases and inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 and Fms. Synonyms: AZ628; AZ-628; AZ 628. Grades: >98%. CAS No. 878739-06-1. Molecular formula: C27H25N5O2. Mole weight: 451.52.
AZD-9291
AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors. AZD9291 is highly active in preclinical models and is well tolerated in animal models. AZD 9291 is an irreversible inhibitor of epidermal growth factor receptor (EGFR) sensitizing and T790M resistance mutations (IC50s = 15-17 nM) while sparing the wild-type form of the receptor (IC50 = 480 nM). It binds the related IGF1R and hERG receptors with significantly reduced potency (IC50s = 2.9 and 16.2 μM, respectively). Uses: For research used only. Synonyms: Mereletinib; EGFR inhibitor; AZD9291; AZD 9291. Grades: 98%. CAS No. 1421373-65-0. Molecular formula: C28H33N7O2. Mole weight: 499.61.
Batoprotafib
Batoprotafib (TNO155) is a potent selective and orally active allosteric inhibitor of wild-type SHP2 ( IC 50 =0.011 μM). Batoprotafib has the potential for the study of RTK-dependent malignancies, especially advanced solid tumors [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TNO155. CAS No. 1801765-04-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136173.
Bavdegalutamide
Bavdegalutamide, also known as ARV-110, effectively targets the wild type Androgen Receptor (AR) and certain genomic alterations of the AR (amplification, T878A, H875Y, F877L, M895V, but not L702H or AR-V7) for degradation in both enzalutamide sensitive and resistant preclinical models. ARV-110 showed promising anti-tumor activity in heavily pretreated men with metastatic castration-resistant prostate cancer (mCRPC). Group: Others. Alternative Names: ARV-110; ARV 110; ARV110; Bavdegalutamide. CAS No. 2222112-77-6. Molecular formula: C41H43ClFN9O6. Mole weight: 812.3. Appearance: Solid powder. Purity: >98%. IUPACName: N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)methyl)piperidin-1-yl)pyridazine-3-carboxamide. Canonical SMILES: ClC1=CC (O[C@H]2CC[C@@H] (CC2)NC (C3=CC=C (N=N3)N4CCC (CC4)CN5CCN (CC5)C6=CC (C (N7C8CCC (NC8=O)=O)=O)=C (C=C6F)C7=O)=O)=CC=C1C#N. Catalog: ACM2222112776.
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