A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Tixagevimab (AZD8895) is a human monoclonal antibody that targets the SARS-CoV-2 receptor binding domain (RBD). It exhibits neutralizing activity against SARS-CoV-2 by binding to the RBD and the S-glycoprotein ectodomain and blocking S-glycoprotein-mediated binding to the receptor [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: AZD8895. CAS No. 2420564-02-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99556.
Tixosil
Tixosil. Group: Polymers.
Tizanidine
Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons. Uses: Scientific research. Group: Signaling pathways. CAS No. 51322-75-9. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0194.
Tizanidine-d4
Tizanidine-d 4 is the deuterium labeled Tizanidine. Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons[1][2]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 1188331-19-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B0194S.
Tizanidine-d4
Labeled Tizanidine, a muscle relaxant. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
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Tizanidine-[d4]
Tizanidine-[d4] is the labelled analogue of Tizanidine. Tizanidine is an α2 adrenergic agonist used as a muscle relaxant. Synonyms: Tizanidine D4; 5-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl-d4)-2,1,3-benzothiadiazol-4-amine. Grade: 100% HPLC; 99% atom D. CAS No. 1188331-19-2. Molecular formula: C9H4DClN5S. Mole weight: 257.74.
Tizanidine-[d4] Hydrochloride
Tizanidine-[d4] Hydrochloride is the labelled analogue of Tizanidine, which has been found to be an α2-adrenergic agonist and could be used as a muscle as well as skeletal relaxant. Synonyms: Tizanidine-d4 Hydrochloride; 5-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl-d4)-2,1,3-benzothiadiazol-4-amine Hydrochloride. Grade: 95% by HPLC; 95% atom D. CAS No. 1188263-51-5. Molecular formula: C9H5D4Cl2N5S. Mole weight: 294.20.
Tizanidine hydrochloride
Tizanidine hydrochloride is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons. Uses: Scientific research. Group: Signaling pathways. CAS No. 64461-82-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0194A.
Tizanidine hydrochloride
Tizanidine hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 64461-82-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Tizanidine hydrochloride
5g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C9H8N5ClS ¢HCl. CAS No. 64461-82-1. Prepack ID 71395830-5g. Molecular Weight 290.17. See USA prepack pricing.
Tizanidine, Hydrochloride
An α2-adrenergic agonist; centrally active myotonolytic. A muscle relaxant (skeletal). Group: Biochemicals. Grades: Highly Purified. CAS No. 64461-82-1. Pack Sizes: 10mg, 50mg, 100mg, 250mg. Molecular Formula: C?H?Cl?N?S. US Biological Life Sciences.
Worldwide
Tizanidine Related Compound A
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Tizanidine Related Compound B
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Tizanidine Related Compound C
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Tizoxanide
A metabolite of Nitazoxonide. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
Tizoxanide
Tizoxanide (TIZ) is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide (TIZ) has anti-HIV-1 activities and potent inhibition of both HBV and HCV replication with values EC50 of 0.46μM and 0.15 μM, respectively. Tizoxanide also exerts anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and suppressing of the activation of the NF-κB and the MAPK signaling pathways in LPS-treated macrophage cells. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Solid. CAS No. 173903-47-4. Molecular formula: C10H7N3O4S. Mole weight: 265.243. Purity: 0.97. Canonical SMILES: O=C(NC1=NC=C([N+]([O-])=O)S1)C2=CC=CC=C2O. Product ID: ACM173903474. Alfa Chemistry ISO 9001:2015 Certified.
Tizoxanide
Tizoxanide (TIZ) is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide (TIZ) has anti-HIV-1 activities and potent inhibition of both HBV and HCV replication with values EC 50 of 0.46μM and 0.15 μM, respectively. Tizoxanide also exerts anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and suppressing of the activation of the NF-κB and the MAPK signaling pathways in LPS-treated macrophage cells [1] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TIZ. CAS No. 173903-47-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12687.
Tizoxanide-[d4]
Tizoxanide-[d4] is the labelled analogue of Tizoxanide. Tizoxanide is the active metabolite of nitazoxanide, an anti-infective that has been approved for the treatment of diarrhea caused by Giardia lamblia or Crytosporidium parvum. Tizoxanide is active against anaerobic bacteria, protozoan parasites, and viruses. Synonyms: Tizoxanide D4; 2-Hydroxy-N-(5-nitro-2-thiazolyl)benzamide-d4. Grade: 95% by HPLC; 98% atom D. CAS No. 1246817-56-0. Molecular formula: C10H3D4N3O4S. Mole weight: 269.27.
TiZrVTa High-Entropy Alloy
Unlike most current alloy materials, high-entropy alloys are alloy materials that contain equimolar or approximately equimolar elements. TiZrVTa High-Entropy Alloy is composed of Ti, Zr, V, and Ta. Uses: Military use, replace part of superalloy. Group: High entropy alloys. Pack Sizes: Our TiZrVTa High-Entropy Alloy is carefully handled during storage and transportation to preserve the quality of our product in its original condition.
TJ-M2010-5
TJ-M2010-5 is a MyD88 inhibitor that binds to the TIR domain of MyD88 to interfere with its homodimerization, and the TLR/MyD88 signal pathway[1][2]. TJ-M2010-5 can be used for the research of myocardial ischemia/reperfusion injury (MIRI)[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1357471-57-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139397.
TK05
TK05 is a potent and selective inhibitor of leukotriene C 4 synthase (LTC4S) with an IC 50 of 95 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1245734-61-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117143.
TK-129
TK-129 is an orally active, low-toxicity, potent KDM5B inhibitor (with high affinity; IC50=44 nM). TK-129 exerts cardioprotective effects by inhibiting KDM5B and blocking the KDM5B-associated Wnt pathway. TK-129 reduces ang II-induced activation of cardiac fibroblasts in vitro and reduces isoprenaline-induced myocardial remodelling and fibrosis in vivo. TK-129 can be used in studies of cardiovascular disease[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3031476-73-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151483.
TK216
TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor[1]. TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1903783-48-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122903.
TKIM
TKIM is a TREK-1 channel inhibitor with an IC 50 of 2.96 μM. TKIM binds to the pocket of the intermediate (IM) state of TREK-1 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 326921-25-9. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-134559.
TL02-59
TL02-59 is an orally active, selective Src-family kinase Fgr inhibitor with an IC 50 of 0.03 nM. TL02-59 inhibits Lyn and Hck with IC 50 s of 0.1 nM and 160 nM, respectively. TL02-59 potently suppresses acute myelogenous leukemia (AML) cell growth [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1315330-17-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112852.
TL-119
TL-119 is an antibiotic isolated from Bacillus subtilis. It is effective against gram-positive bacteria and fungi. Synonyms: Antibiotic TL-119; TL 119. CAS No. 55599-68-3. Molecular formula: C42H57N7O9. Mole weight: 803.9.
TL-1A human
recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
TL8-506
TL8-506 is a specific TLR8 agonist with an EC50 of 30?nM. TL8-506 has immunomodulatory effects and can be used in the study of tuberculosis and cancer immunotherapy[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1268163-15-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-20457.
TL-895
TL-895 is a potent, orally active, ATP-competitive, and highly selective irreversible BTK inhibitor with an IC 50 and a K i of 1.5 nM and 11.9 nM, respectively [1]. TL-895 is used be for JAKi-relapsed/refractory myelofibrosis, acute myeloid leukemia, COVID-19 and cancer research [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1415823-49-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139481.
TLQP 21 is a VGF-derived peptide. TLQP 21 has been shown to protect cerebellar granule cells (CGCs) from serum and potassium deprivation-induced apoptosis. TLQP 21 has the potential for the prevention of early phase diet-induced diabetes. Synonyms: TLQP 21; TLQP21; TLQP-21. Grade: ≥95%. CAS No. 869988-94-3. Molecular formula: C107H170N40O26. Mole weight: 2432.7.
TLQP 21
TLQP 21. Group: Biochemicals. Grades: Purified. CAS No. 869988-94-3. Pack Sizes: 1mg. US Biological Life Sciences.
A cell-permeable benzotropolone compound that competes against Pam3CSK4- for TLR1/TLR2 heterodimer binding (Ki = 410nM) and selectively antagonizes against Pam3CSK4-induced RAW264.7 cellular NO production (IC50 = 580nM) without apparent cytotoxicity (up to 100uM and 24h). Exhibits no antagonist activity toward TLR2/TLR6, TLR3, TLR4, TLR7 at 0.5uM and little inhibitory potency against a panel of 10 kinases at 5uM (by <11% inhibition). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??O?. US Biological Life Sciences.
Worldwide
TLR2-IN-C29
TLR2-IN-C29 is an inhibitor of TLR2/1 and TLR2/6 signaling. It is induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages. Uses: Designed for use in research and industrial production. Additional or Alternative Names: TLR2-IN-C29; TLR2 IN C29; TLR2INC29; TLR2-inhibitor-C29; TLR2 inhibitor-C29; TLR2 inhibitor C29. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 363600-92-4. Molecular formula: C16H15NO4. Mole weight: 285.29. Purity: >98%. IUPACName: 3-[[(2-Hydroxy-3-methoxyphenyl)methylene]amino]-2-methyl-benzoic acid. Canonical SMILES: O=C(O)C1=CC=CC(/N=C/C2=CC=CC(OC)=C2O)=C1C. Product ID: ACM363600924. Alfa Chemistry ISO 9001:2015 Certified.
TLR3, Control Peptide (Toll Like Receptor 3)
TLR3, Control Peptide (Toll Like Receptor 3). Group: Molecular Biology. Grades: Highly Purified. Pack Sizes: 100ug. US Biological Life Sciences.
A thiophene carboxamidopropionate compound that acts as a direct, competitive and high affinity inhibitor of dsRNA binding to TLR3 (Ki=2.96uM; =19nM for dsRNA binding to TLR3) and selectively antagonizes stimulated TLR3 signaling without affecting TLR1/2, TLR2/6, TLR4 and TLR7 pathways. Shown to efficiently repress TNF-a and IL-1b (IC90=27uM) and NO production (IC50=3.44uM) in Poly(I:C)-induced RAW 264.7 macrophages. Exhibits minimal cytotoxicity (IC50>100uM in RAW 264.7 cells) and is weakly active against a panel of 12-representative kinases and 4-cytochrome enzymes (in vitro assays). Group: Biochemicals. Alternative Names: (R) -2- (3-Chloro-6-fluorobenzo [b]thiophene-2-carboxamido) -3-phenylpropanoic Acid; CU CPT 4a. Grades: Highly Purified. CAS No. 1279713-77-7. Pack Sizes: 10mg. Molecular Formula: C18H13ClFNO3S, Molecular Weight: 377.8. US Biological Life Sciences.
Worldwide
TLR-3 human
recombinant, expressed in HEK 293 cells, ?95% (SDS-PAGE), ?95% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
TLR4-IN-C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 40592-88-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-107575.
A cell-permeable cyclohexenecarboxylate that disrupts TLR4, but not TLR1-3 or TLR5-10, interaction with adaptor molecules TIRAP and TRAM via direct binding to TLR4 intracellular Cys747 residue.Shown to effectively inhibit TLR4-mediated cellular events (IC50 = 1.8, 1.3, and 1.9nM, respectively, against LPS-induced NO, IL-6, and TNF-alpha production in murine RAW264.7 macrophages) in vitro and completely prevent LPS- (7mg/kg, i.p.) induced death in mice (3mg/kg; i.v.) in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 243984-11-4. Pack Sizes: 5mg. Molecular Formula: C??H??ClFNO?S, Primary Target: TLR4. US Biological Life Sciences.
Worldwide
TLR7/8/9-IN-1
TLR7/8/9-IN-1 is a potent and orally bioavailable small molecule antagonist (IC50 = 43 nM) of Toll-like receptors 7/8/9 (TLR7/8/9). Uses: Scientific research. Group: Signaling pathways. CAS No. 2180127-82-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131952.
TLR7/8 agonist 4 (compound 41) is a potent TLR7/8 agonist. TLR7/8 agonist 4 has anti-cancer activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2388520-33-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139017.
TLR7/8 agonist 8
TLR7/8 agonist 8 (compound 24m) is a potent toll-like receptor 7/8 (TLR7/8) dual agonist, with EC 50 s of 27 and 12 nM for hTLR7 and hTLR8 , respectively. TLR7/8 agonist 8 can improve the antitumor activity of PD-1/PD-L1 blockade [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2649170-16-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-153543.
TLR7 agonist 1
TLR7 agonist 1 is a potent, selective and oral TLR7 agonist with an IC 50 of 90 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 2178156-33-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111358.
TLR9-IN-1
TLR9-IN-1 is a potent and selective TLR9 inhibitor with an IC50 value of 7 nM for human TLR9. TLR9-IN-1 can be used for researching diseases associated with undesirable immune response[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2226366-86-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148045.
TM-1
TM-1 is a potent inhibitor of pyruvate dehydrogenase kinase ( PDHK1 ). TM-1 inhibits PDHK1 and PDHK2 with IC 50 s of 2.97 μM and 5.2 μM, respectively. TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation, and inhibits cell proliferation [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 921099-13-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-136882.
Tm3PyP26PyB
Tm3PyP26PyB. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1,3,5-Tris(6-(3-(pyridin-3-yl)phenyl)pyridin-2-yl)benzene. Product Category: Organic Light Emitting Diode (OLED). CAS No. 1492917-78-8. Molecular formula: C54H36N6. Mole weight: 768.9 g/mol. Product ID: ACM1492917788. Alfa Chemistry ISO 9001:2015 Certified.
TM5275 sodium
TM5275 sodium is a plasminogen activator inhibitor (PAI-1) with an IC50 of 6.95 ?M. Uses: Scientific research. Group: Signaling pathways. CAS No. 1103926-82-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100447.
TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), has IC50 values between 13.9 and 51.1 ?M and induces intrinsic apoptosis in several human cancer cell lines. TM5441 attenuates N?-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1190221-43-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101761.
TMAD
TMAD. Group: Biochemicals. Alternative Names: 1,1'-Azobis(N,N'-dimethylformamide); N, N, N', N'-Tetra methyl azodicarboxamide. Grades: Highly Purified. CAS No. 10465-78-8. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C6H12N4O2. US Biological Life Sciences.
Worldwide
TMA-DPH
TMA-DPH is a hydrophobic fluorescent membrane probe (Ex=355 nm; Em=430 nm). TMA-DPH is able to anchor on the cell surface and localize to different regions of the phospholipid bilayer. By analyzing the fluorescence polarization values of TMA-DPH in the plasma membrane and membrane substructures, the fluidity of the cell membrane can be determined [1] [2] [3]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 115534-33-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-D0986.
TMAH
Tetramethylammonium hydroxide is a solid in the hydrated form or a colorless liquid with a strong ammonia-like odor. It is soluble in water. It is corrosive to metals and tissue.;Liquid. Group: Polymers. CAS No. 75-59-2. Product ID: tetramethylazanium; hydroxide. Molecular formula: 91.15g/mol. Mole weight: C4H13NO. C[N+](C)(C)C.[OH-]. InChI=1S/C4H12N.H2O/c1-5(2, 3)4;/h1-4H3;1H2/q+1;/p-1. WGTYBPLFGIVFAS-UHFFFAOYSA-M.