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This enzyme is important for the maintenance of the correct reading frame during translation. Unlike TrmD from Escherichia coli, which recognizes the G36pG37 motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37. Group: Enzymes. Synonyms: TrmD; tRNA (m1G37) methyltransferase; transfer RNA (m1G37) methyltransferase; Trm5p; TRMT5; tRNA-(N1G37) methyltransferase; MJ0883 (gene name). Enzyme Commission Number: EC 2.1.1.228. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1831; tRNA (guanine37-N1)-methyltransferase; EC 2.1.1.228; TrmD; tRNA (m1G37) methyltransferase; transfer RNA (m1G37) methyltransferase; Trm5p; TRMT5; tRNA-(N1G37) methyltransferase; MJ0883 (gene name). Cat No: EXWM-1831.
tRNA (guanine46-N7)-methyltransferase
The enzyme specifically methylates guanine46 at N7 in tRNA. Group: Enzymes. Synonyms: Trm8/Trm82; TrmB; tRNA (m7G46) methyltransferase; transfer ribonucleate guanine 7-methyltransferase; 7-methylguanine transfer ribonucleate methylase; tRNA guanine 7-methyltransferase; N7-methylguanine methylase; S-adenosyl-L-methionine:tRNA (guanine-7-N-)-methyltransferase. Enzyme Commission Number: EC 2.1.1.33. CAS No. 37257-00-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1937; tRNA (guanine46-N7)-methyltransferase; EC 2.1.1.33; 37257-00-4; Trm8/Trm82; TrmB; tRNA (m7G46) methyltransferase; transfer ribonucleate guanine 7-methyltransferase; 7-methylguanine transfer ribonucleate methylase; tRNA guanine 7-methyltransferase; N7-methylguanine methylase; S-adenosyl-L-methionine:tRNA (guanine-7-N-)-methyltransferase. Cat No: EXWM-1937.
tRNA (guanine6-N2)-methyltransferase
The enzyme specifically methylates guanine6 at N2 in tRNA. Group: Enzymes. Synonyms: methyltransferase Trm14; m2G6 methyltransferase. Enzyme Commission Number: EC 2.1.1.256. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1860; tRNA (guanine6-N2)-methyltransferase; EC 2.1.1.256; methyltransferase Trm14; m2G6 methyltransferase. Cat No: EXWM-1860.
tRNA (guanine9-N1)-methyltransferase
The enzyme from Saccharomyces cerevisiae specifically methylates guanine9. The bifunctional enzyme from Thermococcus kodakaraensis also catalyses the methylation of adenine9 in tRNA (cf. EC 2.1.1.218, tRNA (adenine9-N1)-methyltransferase). Group: Enzymes. Synonyms: Trm10p (ambiguous); tRNA(m1G9/m1A9)-methyltransferase; tRNA(m1G9/m1A9)MTase; tRNA (guanine-N(1)-)-methyltransferase; tRNA m1G9-methyltransferase; tRNA m1G9 MTase. Enzyme Commission Number: EC 2.1.1.221. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1824; tRNA (guanine9-N1)-methyltransferase; EC 2.1.1.221; Trm10p (ambiguous); tRNA(m1G9/m1A9)-methyltransferase; tRNA(m1G9/m1A9)MTase; tRNA (guanine-N(1)-)-methyltransferase; tRNA m1G9-methyltransferase; tRNA m1G9 MTase. Cat No: EXWM-1824.
tRNA (guanosine18-2'-O)-methyltransferase
The enzyme catalyses the methylation of guanosine18 in tRNA. Group: Enzymes. Synonyms: tRNA (Gm18) 2'-O-methyltransferase; tRNA (Gm18) methyltransferase; TrmH; SpoU. Enzyme Commission Number: EC 2.1.1.34. CAS No. 37257-01-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1938; tRNA (guanosine18-2'-O)-methyltransferase; EC 2.1.1.34; 37257-01-5; tRNA (Gm18) 2'-O-methyltransferase; tRNA (Gm18) methyltransferase; TrmH; SpoU. Cat No: EXWM-1938.
tRNA-guanosine34 transglycosylase
Certain prokaryotic and eukaryotic tRNAs contain the modified base queuine at position 34. In eukaryotes queuine is salvaged from food and incorporated into tRNA directly via a base-exchange reaction, replacing guanine. In eubacteria, which produce queuine de novo, the enzyme catalyses the exchange of guanine with the queuine precursor preQ1, which is ultimately modified to queuosine. The eubacterial enzyme can also use an earlier intermediate, preQ0, to replace guanine in unmodified tRNATyr and tRNAAsn. This enzyme acts after EC 1.7.1.13, preQ1 synthase, in the queuine-biosynthesis pathway. Group: Enzymes. Synonyms: guanine insertion enzyme (ambiguous); tRNA transglycosylase (ambiguou. Enzyme Commission Number: EC 2.4.2.29. CAS No. 72162-89-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2656; tRNA-guanosine34 transglycosylase; EC 2.4.2.29; 72162-89-1; guanine insertion enzyme (ambiguous); tRNA transglycosylase (ambiguous); Q-insertase (ambiguous); queuine34 transfer ribonucleate ribosyltransferase; transfer ribonucleate glycosyltransferase (ambiguous); tRNA guanine34 transglycosidase; queuine tRNA-ribosyltransferase (ambiguous); TGT; [tRNA]-guanine34:queuine tRNA-D-ribosyltransferase; transfer ribonucleic acid guanine34 transglycosylase. Cat No: EXWM-2656.
tRNAHis guanylyltransferase
In eukarya an additional guanosine residue is added post-transcriptionally to the 5'-end of tRNAHis molecules. The addition occurs opposite a universally conserved adenosine73 and is thus the result of a non-templated 3'-5' addition reaction. The additional guanosine residue is an important determinant for aminoacylation by EC 6.1.1.21, histidyl-tRNA ligase.The enzyme requires a divalent cation for activity. ATP activation is not required when the substrate contains a 5'-triphosphate (ppp-tRNAHis). Group: Enzymes. Synonyms: histidine tRNA guanylyltransferase; Thg1p (ambiguous); Thg1 (ambiguous). Enzyme Commission Number: EC 2.7.7.79. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3291; tRNAHis guanylyltransferase; EC 2.7.7.79; histidine tRNA guanylyltransferase; Thg1p (ambiguous); Thg1 (ambiguous). Cat No: EXWM-3291.
tRNAIle2-agmatinylcytidine synthase
The enzyme from the archaeon Archaeoglobus fulgidus modifies the wobble base of the CAU anticodon of the archaeal tRNAIle2 at the oxo group in position 2 of cytidine34. This modification is crucial for accurate decoding of the genetic code. In bacteria EC 6.3.4.19, tRNAIle-lysidine synthase, catalyses the modification of [tRNAIle2]-cytidine34 to [tRNAIle2]-lysidine34. Group: Enzymes. Synonyms: TiaS; AF2259; tRNAIle-2-agmatinylcytidine synthetase; tRNAIle-agm2C synthetase; tRNAIle-agmatidine synthetase. Enzyme Commission Number: EC 6.3.4.22. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5792; tRNAIle2-agmatinylcytidine synthase; EC 6.3.4.22; TiaS; AF2259; tRNAIle-2-agmatinylcytidine synthetase; tRNAIle-agm2C synthetase; tRNAIle-agmatidine synthetase. Cat No: EXWM-5792.
tRNAIle-lysidine synthase
The bacterial enzyme modifies the wobble base of the CAU anticodon of tRNAIle at the oxo group in position 2 of cytidine34. This modification determines both codon and amino acid specificities of tRNAIle. Group: Enzymes. Synonyms: TilS; mesJ (gene name); yacA (gene name); isoleucine-specific transfer ribonucleate lysidine synthetase; tRNAIle-lysidine synthetase. Enzyme Commission Number: EC 6.3.4.19. CAS No. 635304-92-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5788; tRNAIle-lysidine synthase; EC 6.3.4.19; 635304-92-6; TilS; mesJ (gene name); yacA (gene name); isoleucine-specific transfer ribonucleate lysidine synthetase; tRNAIle-lysidine synthetase. Cat No: EXWM-5788.
tRNA-intron lyase
The enzyme catalyses the final stage in the maturation of tRNA molecules. Group: Enzymes. Synonyms: transfer ribonucleate intron endoribonuclease; tRNA splicing endonuclease; splicing endonuclease; tRNATRPintron endonuclease; transfer splicing endonuclease. Enzyme Commission Number: EC 4.6.1.16. CAS No. 117444-13-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5353; tRNA-intron lyase; EC 4.6.1.16; 117444-13-0; transfer ribonucleate intron endoribonuclease; tRNA splicing endonuclease; splicing endonuclease; tRNATRPintron endonuclease; transfer splicing endonuclease. Cat No: EXWM-5353.
tRNA:m4X modification enzyme
The enzyme from Saccharomyces cerevisiae 2'-O-methylates cytidine4 in tRNAPro and tRNAGly(GCC), and adenosine4 in tRNAHis. Group: Enzymes. Synonyms: TRM13; Trm13p; tRNA:Xm4 modification enzyme. Enzyme Commission Number: EC 2.1.1.225. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1828; tRNA:m4X modification enzyme; EC 2.1.1.225; TRM13; Trm13p; tRNA:Xm4 modification enzyme. Cat No: EXWM-1828.
tRNAMet cytidine acetyltransferase
The enzyme acetylates the wobble base cytidine34 of the CAU anticodon of elongation-specific tRNAMet. Escherichia coli TmcA strictly discriminates elongator tRNAMet from tRNAIle, which is structurally similar and has the same anticodon loop, mainly by recognizing the C27-G43 pair in the anticodon stem. The enzyme can use GTP in place of ATP for formation of N4-acetylcytidine. Group: Enzymes. Synonyms: YpfI; TmcA. Enzyme Commission Number: EC 2.3.1.193. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2136; tRNAMet cytidine acetyltransferase; EC 2.3.1.193; YpfI; TmcA. Cat No: EXWM-2136.
The enzyme, which is a member of the S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes superfamily, binds two [4Fe-4S] clusters as well as the transferred sulfur. The sulfur donor is believed to be one of the [4Fe-4S] clusters, which is sacrificed in the process, so that in vitro the reaction is a single turnover. The identity of the electron donor is not known. Group: Enzymes. Synonyms: MtaB; methylthio-threonylcarbamoyl-adenosine transferase B; CDKAL1 (gene name). Enzyme Commission Number: EC 2.8.4.5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3431; tRNA (N6-L-threonylcarbamoyladenosine37-C2)-methylthiotransferase; EC 2.8.4.5; MtaB; methylthio-threonylcarbamoyl-adenosine transferase B; CDKAL1 (gene name). Cat No: EXWM-3431.
tRNA nucleotidyltransferase
Brings about the final exonucleolytic trimming of the 3'-terminus of tRNA precursors in Escherichia coli by a phosphorolysis, producing a mature 3'-terminus on tRNA and nucleoside diphosphate. Not identical with EC 2.7.7.8 polyribonucleotide nucleotidyltransferase. Group: Enzymes. Synonyms: phosphate-dependent exonuclease; RNase PH; ribonuclease PH. Enzyme Commission Number: EC 2.7.7.56. CAS No. 116412-36-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3267; tRNA nucleotidyltransferase; EC 2.7.7.56; 116412-36-3; phosphate-dependent exonuclease; RNase PH; ribonuclease PH. Cat No: EXWM-3267.
The enzyme, which is found in all eukaryotes and in the majority of Euryarchaeota (but not in the Crenarchaeota), is involved in the hypermodification of the guanine nucleoside at position 37 of tRNA leading to formation of assorted wye bases. This modification is essential for translational reading-frame maintenance. The eukaryotic enzyme is involved in biosynthesis of the tricyclic base wybutosine, which is found only in tRNAPhe. Group: Enzymes. Synonyms: TYW2; tRNA-yW synthesizing enzyme-2; TRM12 (gene name); taw2 (gene name). Enzyme Commission Number: EC 2.5.1.114. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2730; tRNAPhe (4-demethylwyosine37-C7) aminocarboxypropyltransferase; EC 2.5.1.114; TYW2; tRNA-yW synthesizing enzyme-2; TRM12 (gene name); taw2 (gene name). Cat No: EXWM-2730.
The enzyme is involved in the biosynthesis of hypermodified tricyclic bases found at position 37 of certain tRNAs. These modifications are important for translational reading-frame maintenance. The enzyme is found in all eukaryotes and in some archaea, but not in bacteria. The eukaryotic enzyme is involved in the biosynthesis of wybutosine. Group: Enzymes. Synonyms: TYW3 (gene name); tRNA-yW synthesizing enzyme-3. Enzyme Commission Number: EC 2.1.1.282. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1889; tRNAPhe 7-[(3-amino-3-carboxypropyl)-4-demethylwyosine37-N4]-methyltransferase; EC 2.1.1.282; TYW3 (gene name); tRNA-yW synthesizing enzyme-3. Cat No: EXWM-1889.
Requires Fe2+. The enzyme is not active with wybutosine. Group: Enzymes. Synonyms: TYW5; tRNA yW-synthesizing enzyme 5. Enzyme Commission Number: EC 1.14.11.42. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0661; tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase; EC 1.14.11.42; TYW5; tRNA yW-synthesizing enzyme 5. Cat No: EXWM-0661.
The enzyme is found only in eukaryotes, where it is involved in the biosynthesis of wybutosine, a hypermodified tricyclic base found at position 37 of certain tRNAs. The modification is important for translational reading-frame maintenance. In some species that produce hydroxywybutosine the enzyme uses 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine37 in tRNAPhe as substrate. The enzyme also has the activity of EC 2.3.1.231, tRNAPhe 7-[(3S)-4-methoxy-(3-amino-3-carboxypropyl)wyosine37-O]-carbonyltransferase. Group: Enzymes. Synonyms: TYW4 (ambiguous); tRNA-yW synthesizing enzyme-4 (ambiguous). Enzyme Commission Number: EC 2.1.1.290. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1897; tRNAPhe [7-(3-amino-3-carboxypropyl)wyosine37-O]-methyltransferase; EC 2.1.1.290; TYW4 (ambiguous); tRNA-yW synthesizing enzyme-4 (ambiguous). Cat No: EXWM-1897.
The enzyme is found only in eukaryotes, where it is involved in the biosynthesis of wybutosine, a hypermodified tricyclic base found at position 37 of certain tRNAs. The modification is important for translational reading-frame maintenance. In some species that produce hydroxywybutosine the enzyme uses 7-[2-hydroxy-3-amino-3-(methoxycarbonyl)propyl]wyosine37 in tRNAPhe as substrate. The enzyme also has the activity of EC 2.1.1.290, tRNAPhe [7-(3-amino-3-carboxypropyl)wyosine37-O]-methyltransferase. Group: Enzymes. Synonyms: TYW4 (ambiguous); tRNA-yW synthesizing enzyme-4 (ambiguous). Enzyme Commission Number: EC 2.3.1.231. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2179; tRNAPhe {7-[3-amino-3-(methoxycarbonyl)propyl]wyosine37-N}-methoxycarbonyltransferase; EC 2.3.1.231; TYW4 (ambiguous); tRNA-yW synthesizing enzyme-4 (ambiguous). Cat No: EXWM-2179.
tRNA pseudouridine13 synthase
Pseudouridine synthase TruD from Escherichia coli specifically acts on uridine13 in tRNA. The Pus7 protein from Saccharomyces cerevisiae is a multisite-multisubstrate pseudouridine synthase that is able to modify uridine13 in several yeast tRNAs, uridine35 in the pre-tRNATyr, uridine35 in U2 small nuclear RNA, and uridine50 in 5S rRNA. Group: Enzymes. Synonyms: TruD; YgbO; tRNA PSI13 synthase; RNA:PSI-synthase Pus7p; Pus7p; RNA:pseudouridine-synthase Pus7p; Pus7 protein. Enzyme Commission Number: EC 5.4.99.27. CAS No. 430429-15-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5567; tRNA pseudouridine13 synthase; EC 5.4.99.27; 430429-15-5; TruD; YgbO; tRNA PSI13 synthase; RNA:PSI-synthase Pus7p; Pus7p; RNA:pseudouridine-synthase Pus7p; Pus7 protein. Cat No: EXWM-5567.
tRNA pseudouridine31 synthase
The enzyme specifically acts on uridine31 in tRNA. Group: Enzymes. Synonyms: Pus6p. Enzyme Commission Number: EC 5.4.99.42. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5584; tRNA pseudouridine31 synthase; EC 5.4.99.42; Pus6p. Cat No: EXWM-5584.
tRNA pseudouridine32 synthase
The dual-specificity enzyme from Escherichia coli also catalyses the formation of pseudouridine746 in 23S rRNA. cf. EC 5.4.99.29 (23S rRNA pseudouridine746 synthase). Group: Enzymes. Synonyms: RluA (ambiguous); pseudouridine synthase RluA (ambiguous); Pus9p; Rib2/Pus8p. Enzyme Commission Number: EC 5.4.99.28. CAS No. 430429-15-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5568; tRNA pseudouridine32 synthase; EC 5.4.99.28; 430429-15-5; RluA (ambiguous); pseudouridine synthase RluA (ambiguous); Pus9p; Rib2/Pus8p. Cat No: EXWM-5568.
tRNA pseudouridine38/39 synthase
The enzyme from Saccharomyces cerevisiae is active only towards uridine38 and uridine39, and shows no activity with uridine40 (cf. EC 5.4.99.12, tRNA pseudouridine38-40 synthase). In vitro the enzyme from mouse is active on uridine39 and very slightly on uridine38 (human tRNALeu). Group: Enzymes. Synonyms: Deg1; Pus3p; pseudouridine synthase 3. Enzyme Commission Number: EC 5.4.99.45. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5587; tRNA pseudouridine38/39 synthase; EC 5.4.99.45; Deg1; Pus3p; pseudouridine synthase 3. Cat No: EXWM-5587.
tRNA pseudouridine38-40 synthase
The uridylate residues at positions 38, 39 and 40 of nearly all tRNAs are isomerized to pseudouridine. TruA specifically modifies uridines at positions 38, 39, and/or 40 in the anticodon stem loop of tRNAs with highly divergent sequences and structures. Group: Enzymes. Synonyms: TruA; tRNA pseudouridine synthase I; PSUI; hisT (gene name). Enzyme Commission Number: EC 5.4.99.12. CAS No. 61506-89-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5551; tRNA pseudouridine38-40 synthase; EC 5.4.99.12; 61506-89-6; TruA; tRNA pseudouridine synthase I; PSUI; hisT (gene name). Cat No: EXWM-5551.
tRNA (pseudouridine54-N1)-methyltransferase
While this archaeal enzyme is specific for the 54 position and does not methylate pseudouridine at position 55, the presence of pseudouridine at position 55 is necessary for the efficient methylation of pseudouridine at position 54. Group: Enzymes. Synonyms: TrmY; m1ψ methyltransferase. Enzyme Commission Number: EC 2.1.1.257. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1861; tRNA (pseudouridine54-N1)-methyltransferase; EC 2.1.1.257; TrmY; m1ψ methyltransferase. Cat No: EXWM-1861.
tRNA pseudouridine55 synthase
Pseudouridine synthase TruB from Escherichia coli specifically modifies uridine55 in tRNA molecules. The bifunctional archaeal enzyme also catalyses the pseudouridylation of uridine54. It is not known whether the enzyme from Escherichia coli can also act on position 54 in vitro, since this position is occupied in Escherichia coli tRNAs by thymine. Group: Enzymes. Synonyms: TruB; aCbf5; Pus4; YNL292w (gene name); ψ55 tRNA pseudouridine synthase; tRNA:ψ55-synthase; tRNA pseudouridine 55 synthase; tRNA:pseudouridine-55 synthase; ψ55 synthase; tRNA ψ55 synthase; tRNA:ψ55 synthase; tRNA-uridine55 uracil mutase; Pus10; tRNA-uridine54/55 uracil mutase. Enzyme Commission Number: EC 5.4.99.25. CAS No. 430429-15-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5565; tRNA pseudouridine55 synthase; EC 5.4.99.25; 430429-15-5; TruB; aCbf5; Pus4; YNL292w (gene name); ψ55 tRNA pseudouridine synthase; tRNA:ψ55-synthase; tRNA pseudouridine 55 synthase; tRNA:pseudouridine-55 synthase; ψ55 synthase; tRNA ψ55 synthase; tRNA:ψ55 synthase; tRNA-uridine55 uracil mutase; Pus10; tRNA-uridine54/55 uracil mutase. Cat No: EXWM-5565.
tRNA pseudouridine65 synthase
TruC specifically modifies uridines at positions 65 in tRNA. Group: Enzymes. Synonyms: TruC; YqcB. Enzyme Commission Number: EC 5.4.99.26. CAS No. 430429-15-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5566; tRNA pseudouridine65 synthase; EC 5.4.99.26; 430429-15-5; TruC; YqcB. Cat No: EXWM-5566.
tRNA-queuosine β-mannosyltransferase
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. Group: Enzymes. Enzyme Commission Number: EC 2.4.1.110. CAS No. 9055-6-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2337; tRNA-queuosine β-mannosyltransferase; EC 2.4.1.110; 9055-06-5. Cat No: EXWM-2337.
tRNASer (uridine44-2'-O)-methyltransferase
The 2'-O-methylation of uridine44 contributes to stability of tRNASer(CGA). Group: Enzymes. Synonyms: TRM44. Enzyme Commission Number: EC 2.1.1.211. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1813; tRNASer (uridine44-2'-O)-methyltransferase; EC 2.1.1.211; TRM44. Cat No: EXWM-1813.
tRNase Z
No cofactor requirements. An homologous enzyme to that found in Arabidopsis thaliana has been found in Methanococcus janaschii. Group: Enzymes. Synonyms: 3 tRNase; tRNA 3 endonuclease; RNase Z; 3' tRNase. Enzyme Commission Number: EC 3.1.26.11. CAS No. 98148-84-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3587; tRNase Z; EC 3.1.26.11; 98148-84-6; 3 tRNase; tRNA 3 endonuclease; RNase Z; 3' tRNase. Cat No: EXWM-3587.
tRNA sulfurtransferase
A group of enzymes transferring sulfur to various nucleotides in a tRNA chain, producing residues such as 4-thiouridylate. With some enzymes mercaptopyruvate can act as sulfur donor. Group: Enzymes. Synonyms: transfer ribonucleate sulfurtransferase; RNA sulfurtransferase; ribonucleate sulfurtransferase; transfer RNA sulfurtransferase; transfer RNA thiolase. Enzyme Commission Number: EC 2.8.1.4. CAS No. 9055-57-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3362; tRNA sulfurtransferase; EC 2.8.1.4; 9055-57-6; transfer ribonucleate sulfurtransferase; RNA sulfurtransferase; ribonucleate sulfurtransferase; transfer RNA sulfurtransferase; transfer RNA thiolase. Cat No: EXWM-3362.
tRNAThr (cytosine32-N3)-methyltransferase
The enzyme from Saccharomyces cerevisiae specifically methylates cytosine32 in tRNAThr and in tRNASer. Group: Enzymes. Synonyms: ABP140; Trm140p. Enzyme Commission Number: EC 2.1.1.268. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1873; tRNAThr (cytosine32-N3)-methyltransferase; EC 2.1.1.268; ABP140; Trm140p. Cat No: EXWM-1873.
tRNA (uracil54-C5)-methyltransferase
Unlike this enzyme, EC 2.1.1.74 (methylenetetrahydrofolate-tRNA-(uracil54-C5)-methyltransferase (FADH2-oxidizing)), uses 5,10-methylenetetrahydrofolate and FADH2 to supply the atoms for methylation of U54. Group: Enzymes. Synonyms: transfer RNA uracil54 5-methyltransferase; transfer RNA uracil54 methylase; tRNA uracil54 5-methyltransferase; m5U54-methyltransferase; tRNA:m5U54-methyltransferase; RUMT; TrmA; 5-methyluridine54 tRNA methyltransferase; tRNA(uracil-54,C5)-methyltransferase; Trm2; tRNA(m5U54)methyltransferase. Enzyme Commission Number: EC 2.1.1.35. CAS No. 37257-02-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1939; tRNA (uracil54-C5)-methyltransferase; EC 2.1.1.35; 37257-02-6; transfer RNA uracil54 5-methyltransferase; transfer RNA uracil54 methylase; tRNA uracil54 5-methyltransferase; m5U54-methyltransferase; tRNA:m5U54-methyltransferase; RUMT; TrmA; 5-methyluridine54 tRNA methyltransferase; tRNA(uracil-54,C5)-methyltransferase; Trm2; tRNA(m5U54)methyltransferase. Cat No: EXWM-1939.
tRNA-uridine 2-sulfurtransferase
The enzyme, found in bacteria, catalyses formation of the 2-thiouridine modification in the wobble position of tRNAGln, tRNALys and tRNAGlu. Group: Enzymes. Synonyms: mnmA (gene name). Enzyme Commission Number: EC 2.8.1.13. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3358; tRNA-uridine 2-sulfurtransferase; EC 2.8.1.13; mnmA (gene name). Cat No: EXWM-3358.
tRNA-uridine aminocarboxypropyltransferase
The enzyme was studied in the bacterium Escherichia coli. The modification is found in the variable loop of the tRNA. Group: Enzymes. Synonyms: S-adenosyl-L-methionine:tRNA-uridine 3-(3-amino-3-carboxypropyl)transferase. Enzyme Commission Number: EC 2.5.1.25. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2762; tRNA-uridine aminocarboxypropyltransferase; EC 2.5.1.25; S-adenosyl-L-methionine:tRNA-uridine 3-(3-amino-3-carboxypropyl)transferase. Cat No: EXWM-2762.
TRO 19622. Group: Biochemicals. Grades: Purified. CAS No. 22033-87-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Trodat
Trodat. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Ethanethiol, 2-[[2-[[[(1R,2R,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]oct-2-yl]methyl](2-mercaptoethyl)amino]ethyl]amino]-, trifluoroacetate salt (1:3);Ethanethiol, 2-[[2-[[[3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]-oct-2-yl]methyl](2-mercaptoethyl)amino]ethyl]amino]-, [1R-(exo,exo)]-, trifluoroacetate salt (1:3);TRODAT;tropantiol;2-[[2-[[[(1R,2R,3S,5S)-3-(4-Chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]oct-2-yl]methyl](2-mercaptoethyl)amino]ethyl]amino]ethanethiol;Unii-7844H41L5z. Product Category: Heterocyclic Organic Compound. CAS No. 189950-11-6. Molecular formula: C21H34ClN3S2C6H3F9O6. Mole weight: 428.1. Density: 1.143. Product ID: ACM189950116. Alfa Chemistry ISO 9001:2015 Certified.
Troethylene Tetramine 112-24-3
Troethylene Tetramine - Surface Coatings. SUPPLIERS TO BUSINESS CUSTOMERS ONLY.
North America & APAC
Trofinetide
Trofinetide (NNZ-2566), a synthetic analogue of the endogenous N-terminus tripeptide, Glycine-Proline-Glutamate (GPE), has been shown to be neuroprotective in animal models of brain injury. Uses: Scientific research. Group: Peptides. Alternative Names: NNZ-2566. CAS No. 853400-76-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16757.
Trofinetide Impurity 3
Trofinetide Impurity 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1138-80-3. Molecular formula: C10H11NO4. Mole weight: 209.2. Catalog: APB1138803.
Trofosfamide
Antineoplastic; one derivative. Group: Biochemicals. Alternative Names: N,N,3-Tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-Oxide. Grades: Highly Purified. CAS No. 22089-22-1. Pack Sizes: 250mg. US Biological Life Sciences.
Worldwide
Trofosfamide
Trofosfamide is an orally bioavailable oxazaphosphorine derivative with antineoplastic activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 22089-22-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-119824.
Troglitazone
Troglitazone. Group: Biochemicals. Grades: Purified. CAS No. 97322-87-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Troglitazone
Troglitazone is an orally active PPARγ agonist, with EC 50 s of 550 nM and 780 nM for human and murine?PPARγ receptor, respectively. Troglitazone has anticancer activity, prevents and inhibits the development of type 2 diabetes. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CS-045. CAS No. 97322-87-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50935.
An oral hypoglycemic agent which improves insulin sensitivity and decreases hepatic glucose production. Group: Biochemicals. Alternative Names: 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]-phenyl]methyl]-2,4-thiazolidinedione, Romglizone, CS-045, CI-991,Noscal. Grades: Highly Purified. CAS No. 97322-87-7. Pack Sizes: 10mg. US Biological Life Sciences.
An antidiabetic thiazolidinedione (TDZ) drug with anti-inflammatory and anti-tumor activities. A potent and selective PPARγ agonist. The EC50 values for transactivation of human and murine PPARγ in a cell-based assay are 0.55 and 0.78uM, respectively. Group: Biochemicals. Alternative Names: (±)-5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione. Grades: Highly Purified. CAS No. 97322-87-7. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Troglitazone (5-phenyl]methyl]-2,4-thiazolidinedione, Romglizone, BRN 4338399, CS-045, CI-991, GR 92132X)
Potent and selective PPARgamma agonist with no activation of PPARalpha and PPARdelta. Anti-diabetic agent with potent glucose-lowering effects and decreasing insulin resistance in adipose tissues. Stimulates adipogenesis. Apoptosis and cell cycle arrest inducer in several cancer cell lines. Anti-inflammatory. Inhibits vascular smooth muscle cell (VSMC) migration. Group: Biochemicals. Alternative Names: 5-phenyl]methyl]-2,4-thiazolidinedione, Romglizone, BRN 4338399, CS-045, CI-991, GR 92132X. Grades: Highly Purified. CAS No. 97322-87-7. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Troglitazone-[d4]
One of the isotopic labelled form of Troglitazone, which could be used for the treatment of diabetes and inflammation. Synonyms: 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione-d4. Molecular formula: C24H23NO5SD4. Mole weight: 445.57.
Troleandomycin (Triacetyloleandomycin), a macrolide acrolide antibiotic, is a selective CYP3A inhibitor. Troleandomycin is an oral corticosteroid for asthma study[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Triacetyloleandomycin. CAS No. 2751-9-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-108881.
Trolox
Trolox. Group: Biochemicals. Alternative Names: 3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic Acid; (±)-3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-Benzopyran-2-carboxylic Acid; (R,S)-6-Hydroxy-2,5,7,8-tetramethyl-2-chromanecarboxylic Acid; (±)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid; (±)-Trolox; 6-Hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carboxylic Acid; 6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic Acid; Trolox C. Grades: Highly Purified. CAS No. 53188-07-1. Pack Sizes: 1g. Molecular Formula: C14H18O4, Molecular Weight: 250.29. US Biological Life Sciences.
Worldwide
Trolox
Trolox is an analogue of vitamin E with a powerful antioxidant effect. Trolox is also a powerful inhibitor of membrane damage [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 53188-07-1. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-101445.
Trolox
Trolox. Uses: Designed for use in research and industrial production. Additional or Alternative Names: TIMTEC-BB SBB005933;TROLOX;TROLOX(R);TROLOXTM C;6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID;(+/-)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMANE-2-CARBOXYLIC ACID;6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC;6-HYDROXYTETRAMETHYLCHROMAN-2-CARBOXYLI. Product Category: Heterocyclic Organic Compound. CAS No. 56305-04-5. Molecular formula: C14H18O4. Mole weight: 250.29. Product ID: ACM56305045. Alfa Chemistry ISO 9001:2015 Certified.
Trolox is a cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties. It is commonly used as a standard or positive control in antioxidant assays. Trolox is used to assess the role of oxidative injury in processes like neuronal cell death and aging. It has been shown that lipid peroxidation, cytotoxicity, and apoptosis induced by cytochrome P450 2E1 in Hep G2 cells is blocked in the presence of Trolox. Group: Biochemicals. Grades: Highly Purified. CAS No. 53188-07-1. Pack Sizes: 50mg, 250mg. US Biological Life Sciences.
Worldwide
Tromantadine
Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and HSV-2 replication. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 53783-83-8. Molecular formula: C16H28N2O2. Mole weight: 280.409. Product ID: ACM53783838. Alfa Chemistry ISO 9001:2015 Certified.
Tromantadine hydrochloride
Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and HSV-2 replication [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 41544-24-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-U00124B.
Tromethamine
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Trontinemab
Trontinemab (RG6102) is a brain-penetrant, anti-amyloid, bispecific and humanizedized IgG1-κ antibody, targeting to Aβ plaques and transferrin receptor 1 ( TFR1 ). Trontinemab binds to fibrillar Aβ as well as Aβ plaques triggering plaque clearance by engaging immune cells on Alzheimer disease (AD) brain sections. Trontinemab also shows specific affinity to cynomolgus and human TFR1 [1] [2] [3] [4]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: RG6102; RO-7126209. CAS No. 2568868-35-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P9999.
Tropaeolin O
Tropaeolin O. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 25g, 100g. US Biological Life Sciences.
Worldwide
Tropaeolin O
100g Pack Size. Group: Analytical Reagents, Biochemicals, Diagnostic Raw Materials, Stains & Indicators. Formula: C12H10N2O5S.Na. CAS No. 547-57-9. Prepack ID 61804883-100g. Molecular Weight 316.27. See USA prepack pricing.
Tropaeolin OO
25g Pack Size. Group: Stains & Indicators. Formula: C18H14N3O3SNa. CAS No. 554-73-4. Prepack ID 23894342-25g. Molecular Weight 375.38. See USA prepack pricing.
Tropaeolin O sodium salt
Tropaeolin O sodium salt. Group: Biochemicals. Alternative Names: 4- ([2, 4-Dihydroxyphenyl]azo) benzenesulfonic acid sodium salt; Resorcinol Yellow; Acid Orange 6; Chrysoin. Grades: Highly Purified. CAS No. 547-57-9. Pack Sizes: 100g, 250g, 500g, 1kg, 2kg. Molecular Formula: C12H9N2O5SNa. US Biological Life Sciences.
Worldwide
Tropanyl-3,5-dimethylbenzoate
Tropanyl-3,5-dimethylbenzoate. Group: Biochemicals. Grades: Purified. CAS No. 85181-40-4. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
Trophoblast glycoprotein (17-25)
Trophoblast glycoprotein (17-25) is a 9-aa peptide. Trophoblast glycoprotein is a heavily N-glycosylated transmembrane protein belonging to the leucine-rich repeat family of proteins. It is typically expressed during fetal development and cancer. Synonyms: 5T4 oncofetal antigen (17-25); 5T4 oncofetal trophoblast glycoprotein (17-25); Wnt-activated inhibitory factor 1 (17-25).
Tropicacid
Tropicacid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: N-[4-(Acetyloxy)phenyl]-N-ethylacetamide; N-Ethyl-p-aminophenol-diacetyl-deriv.; N-Ethyl-p-aminophenol,N,O-diacetyl derivative. Product Category: Heterocyclic Organic Compound. CAS No. 529-94-6. Molecular formula: C12H15NO3. Mole weight: 221.252. Purity: 0.96. IUPACName: [4-[acetyl(ethyl)amino]phenyl] acetate. Product ID: ACM529946. Alfa Chemistry ISO 9001:2015 Certified. Categories: Tropic acid.
Tropic acid
Tropic acid (DL-Tropic acid) is a laboratory reagent used in the chemical synthesis of Atropine and Hyoscyamine [1]. Uses: Scientific research. Group: Natural products. Alternative Names: DL-Tropic acid. CAS No. 552-63-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg. Product ID: HY-W041194.
Tropic Acid
Tropic Acid is a benzoic acid derivative and thus carries anti-fungal properties. Group: Biochemicals. Alternative Names: α-(Hydroxymethyl)-benzeneacetic Acid; (±)-Tropic Acid; (±)-2-Phenyl-3-hydroxypropionic Acid; (±)-3-Hydroxy-2-phenylpropionic Acid; 2-Phenyl-3-hydroxypropanoic Acid; 2-Phenyl-3-hydroxypropionic Acid; 2-Phenylhydracrylic Acid; 3-Hydroxy-2-phenylpropionic Acid; DL-Tropic Acid; NSC 20990; Tropic Acid. Grades: Highly Purified. CAS No. 529-64-6. Pack Sizes: 1g. US Biological Life Sciences.
Worldwide
Tropicamide
Ophthalmic anticholinergic. Mydriatic. Group: Biochemicals. Alternative Names: N-Ethyl-α - (hydroxymethyl) -N- (4-pyridinylmethyl) benzeneacetamide. Grades: Highly Purified. CAS No. 1508-75-4. Pack Sizes: 100mg. US Biological Life Sciences.