A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
TFFH
TFFH. Group: Biochemicals. Alternative Names: Fluoro-N, N, N', N'-tetra methyl formamidinium hexafluorophosphate. Grades: Highly Purified. CAS No. 164298-23-1. Pack Sizes: 10g, 25g, 50g, 100g, 250g. Molecular Formula: C5H12FN2·F6P. US Biological Life Sciences.
Worldwide
TFFYGGSRGKRNNFKTEEYC
TFFYGGSRGKRNNFKTEEYC is a peptide, which can be used for glioma targeted therapy. Grades: 98%. CAS No. 906480-09-9. Molecular formula: C107H154N30O32S. Mole weight: 2404.6.
TFIIA-p12 human
recombinant, expressed in E. coli, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy.
TFIIA (p12), ? subunit, GST tagged human
recombinant, expressed in E. coli, ?70% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy.
TFIIA-p55 human
recombinant, expressed in E. coli, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy.
TFIIA, p55 subunit, GST tagged human
recombinant, expressed in E. coli, ?70% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy.
TFIIA, reconstituted human
recombinant, expressed in E. coli, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy.
TFIIB, GST tagged human
recombinant, expressed in E. coli, ?70% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy.
recombinant, expressed in E. coli, ?70% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy.
TFLLR-NH2
TFLLR-NH2, derived from the protease-activated receptor-1 (PAR1), is a selective PAR1 agonist with an EC50 of 1.9 μM. Synonyms: TFLLR amide; (Thr1)-TRAP-5 amide; (Thr1)-PAR-1 (1-5) amide (human); PAR-1-activating peptide; PAR-1-AP; L-threonyl-L-phenylalanyl-L-leucyl-L-leucyl-L-argininamide. Grades: 98%. CAS No. 197794-83-5. Molecular formula: C31H53N9O6. Mole weight: 647.81.
TFLLR-NH2
TFLLR-NH2. Group: Biochemicals. Grades: Purified. CAS No. 197794-83-5. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
TFLLR-NH2 2TFA
TFLLR-NH2 2TFA, derived from the protease-activated receptor-1 (PAR1), is a selective PAR1 agonist with an EC50 of 1.9 μM. Synonyms: H-Thr-Phe-Leu-Leu-Arg-NH2.2TFA; TFLLR-NH2.2TFA; L-threonyl-L-phenylalanyl-L-leucyl-L-leucyl-L-argininamide trifluoroacetic acid; PAR-1-AP trifluoroacetate; Protease-activated receptor-1-activating peptide trifluoroacetate. Grades: ≥95%. Molecular formula: C31H53N9O6.2C2HF3O2. Mole weight: 875.87.
TFLLR-NH2(TFA)
TFLLR-NH2, derived from the protease-activated receptor-1 (PAR1), is a selective PAR1 agonist with an EC50 of 1.9 μM. Synonyms: TFLLR-NH2 trifluoroacetate salt; L-threonyl-L-phenylalanyl-L-leucyl-L-leucyl-L-argininamide trifluoroacetic acid. Grades: 99%. CAS No. 1313730-19-6. Molecular formula: C33H54F3N9O8. Mole weight: 761.83.
TFM-4AS-1 is a selective androgen receptor modulator (SARM) , and a potent androgen receptor (AR) ligand with an IC 50 of 38 nM. TFM-4AS-1 is a gene-selective agonist [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 188589-61-9. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-103246.
TFM-4AS-1
TFM-4AS-1. Group: Biochemicals. Grades: Purified. CAS No. 188589-61-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
TFMB-(R)-2-HG
TFMB-(R)-2-HG, a cell membrane-permeable version of (R)-2-HG, is a carcinogenic factor in Acute myeloid leukemia (AML). TFMB-(R)-2-HG impairs SCF ER-Hoxb8 cells differentiation in response to estrogen withdrawal [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1445700-01-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129079.
TFP-PEG3-TFP
TFP-PEG3-TFP. Uses: Designed for use in research and industrial production. Product Category: Other PEG Linkers. CAS No. 1446282-34-3. Molecular formula: C22H18F8O7. Mole weight: 546.09. Purity: 95%+. Product ID: ACM1446282343. Alfa Chemistry ISO 9001:2015 Certified.
TfR-T12
TfR-T12 is a BBB-penetrated transferrin receptor (TfR) binding peptide. CAS No. 344618-30-0. Molecular formula: C71H99N19O15S. Mole weight: 1490.73.
TfR Targeting Peptide
The 12-mer peptide sequence is a transferrin receptor (TfR) targeting peptide. It binds to TfR and is internalized via endocytosis into TfR-expressing cells. TfR targeting peptide is a potential carrier for transportation of small molecules across the blood-brain barrier to the brain, or into malignant tissues. Synonyms: H-Thr-His-Arg-Pro-Pro-Met-Trp-Ser-Pro-Val-Trp-Pro-OH; L-threonyl-L-histidyl-L-arginyl-L-prolyl-L-prolyl-L-methionyl-L-tryptophyl-L-seryl-L-prolyl-L-valyl-L-tryptophyl-L-proline; TfR-T12. Grades: ≥95%. Molecular formula: C71H99N19O15S. Mole weight: 1490.75.
TG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor with IC50 of 20 nM, 200 nM, and 15 nM for Clk1, Clk2, and Clk4, respectively. No inhibitory effect on Clk3, SRPK1, SRPK2, or PKC. Synonyms: (E/Z)-TG003; TG 003; TG-003; 1-(3-Ethyl-5-methoxy-1,3-benzothiazol-2(3H)-ylidene)acetone; 2-Propanone, 1-(3-ethyl-5-methoxy-2(3H)-benzothiazolylidene)-; 1-(3-ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone. Grades: >98%. CAS No. 300801-52-9. Molecular formula: C13H15NO2S. Mole weight: 249.33.
TG 003
TG 003. Group: Biochemicals. Grades: Purified. CAS No. 719277-26-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
TG100-115
TG100-115 is a potent and selective PI3K γ and -δ inhibitor (IC50 values of 83 and 235 nM, respectively) with no effect on PI3Kα or -β (IC50 values > 1 μM). As a gauge of general specificity, TG100-115 was also assayed against a 133 protein kinase panel, none of which was inhibited at IC50 values < 1 μM. Synonyms: TG100115; TG-100115; TG 100115; TG-100-115; TG100-115 ; TG 100-115. 6,7-Bis(3-hydroxyphenyl)pteridine-2,4-diamine; 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol. CAS No. 677297-51-7. Molecular formula: C18H14N6O2. Mole weight: 346.35.
TG 100572
TG 100572 is a multi-targeted kinase inhibitor that inhibits select growth factor receptor tyrosine kinases and Src familt kinases. Synonyms: TG 100572; TG100572; TG-10057. Grades: >98%. CAS No. 867334-05-2. Molecular formula: C26H26ClN5O2. Mole weight: 475.97.
TG 100572 Hydrochloride
TG 100572 is a multi-targeted kinase inhibitor that inhibit select growth factor receptor tyrosine kinases and Src familt kinases for VEGFR1/VEGFR2/FGFR1/Src/Fyn kianse. Synonyms: TG 100572 Hydrochloride; TG100572 Hydrochloride; TG-100572 Hydrochloride. Grades: >98%. CAS No. 867331-64-4. Molecular formula: C26H27Cl2N5O2. Mole weight: 512.43.
TG100713
TG100713 is an inhibitor of PI3-kinase (IC50 values are 24, 50, 165 and 215 nM for PI3Kδ, γ, α and β isoforms respectively). Inhibits endothelial cell proliferation. Synonyms: TG 100713; TG-100713; 3-(2,4-diamino-pteridin-6-yl)-phenol. Grades: 99%. CAS No. 925705-73-3. Molecular formula: C12H10N6O. Mole weight: 254.25.
TG 100713
TG 100713. Group: Biochemicals. Grades: Purified. CAS No. 925705-73-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
TG 100801
TG 100801 is the prodrug of TG 100572, which is a multi-targeted kinase inhibitor that inhibit select growth factor receptor tyrosine kinases and Src familt kinases. It is currently in a clinical trial as a first in class, VEGFr2 targeting, topically applied compound for the treatment of AMD. It is a new drug that inhibits ocular angiogenesis, vascular leak, and inflammation in laboratory studies. Synonyms: TG 100801; TG100801; TG-100801. Grades: >98%. CAS No. 867331-82-6. Molecular formula: C33H30ClN5O3. Mole weight: 580.08.
TG 100801
TG 100801 is a proagent that generates TG 100572 by de-esterification in development to treat age-related macular degeneration. TG 100572 is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases ; has IC 50 s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1 , VEGFR2 , FGFR1 , FGFR2 , PDGFRβ , Fgr , Fyn , Hck , Lck , Lyn , Src , Yes , respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 867331-82-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10186.
TG 100801 Hydrochloride
TG 100801 is the prodrug of TG 100572, which is a multi-targeted kinase inhibitor that inhibit select growth factor receptor tyrosine kinases and Src familt kinases with IC50 values of 2/7/2/1/0.5 nM or VEGFR1/VEGFR2/FGFR1/Src/Fy. Synonyms: TG 100801 Hydrochloride; TG100801 Hydrochloride; TG-100801 Hydrochloride. Grades: >98%. CAS No. 1018069-81-2. Molecular formula: C33H31Cl2N5O3. Mole weight: 616.54.
TG101209
TG101209 is a selective JAK2 inhibitor with IC 50 of 6 nM, less potent to Flt3 and RET with IC 50 of 25 nM and 17 nM, appr 30-fold selective for JAK2 than JAK3, and sensitive to JAK2V617F and MPLW515L/K mutations. Uses: Scientific research. Group: Signaling pathways. CAS No. 936091-14-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10410.
TG101209
TG101209. Group: Biochemicals. Alternative Names: N- (1, 1-Dimethylethyl) -3- [ [5-methyl-2- [ [4- (4-methyl-1-piperazinyl) phenyl] amino] -4-pyrimidinyl] amino] benzenesulfonamide. Grades: Highly Purified. CAS No. 936091-14-4. Pack Sizes: 2.5mg. Molecular Formula: C26H35N7O2S, Molecular Weight: 509.67. US Biological Life Sciences.
Worldwide
TG101209
TG101209 is a novel and potent JAK2 inhibitor. The induction of cytotoxicity was associated with inhibition of cell cycle progression and induction of apoptosis in myeloma cell lines and patient-derived plasma cells. Exploring the mechanism of action of TG101209 indicated downregulation of pJak2, pStat3, and Bcl-xl levels with upregulation of pErk and pAkt levels indicating cross talk between signaling pathways. TG101209, when used in combination with the PI3K inhibitor LY294002, demonstrated synergistic cytotoxicity against myeloma cells. Synonyms: TG101209; TG-101209; TG 101209. Grades: 0.98. CAS No. 936091-14-4. Molecular formula: C26H35N7O2S. Mole weight: 509.67.
TG101348
Fedratinib is a potent and selective JAK2 inhibitor with IC50 value of 6 nM. It also exhibits inhibitory effects against FLT3 (IC50 = 25 nM), RET (IC50 = 17 nM) and JAK3 (IC50 = 169 nM). Synonyms: TG101348; TG 101348; TG-101348; SAR302503; SAR-302503; SAR 302503; Fedratinib; N-tert-butyl-3-[[5-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]pyrimidin-4-yl]amino]benzenesulfonamide. Grades: >98%. CAS No. 936091-26-8. Molecular formula: C27H36N6O3S. Mole weight: 524.68.
TG101348 (SAR302503)
TG101348 is a potent, and selective inhibitor of JAK2 (IC50 = 3 nM). It has a 35- and 334-fold selectivity over JAK3 and JAK1, respectively. Group: Biochemicals. Alternative Names: N-tert-butyl-3- (5-methyl-2- (4- (2- (pyrrolidin-1-yl) ethoxy) phenylamino) pyrimidin-4-ylamino) benzenesulfonamide. Grades: Highly Purified. CAS No. 936091-26-8. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
TG 4-155
TG 4-155. Group: Biochemicals. Grades: Purified. CAS No. 1164462-05-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
TG 4-155
TG 4-155 is a high affinity and selective EP2 receptor antagonist (KB = 2.4 and 34.5 nM for EP2 and DP1 receptors, respectively) displaying >500-fold selectivity over other prostanoid receptors. TG 4-155 inhibits butaprost-induced proinflammatory cytokine production, cell proliferation and invasion of PC-3 cells in vitro. Synonyms: TG4-155; TG-4-155; TG 4-155; TG4155; TG-4155; TG 4155; (2E)-N-[2-(2-Methyl-1H-indol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)-2-propenamide. Grades: ≥98% by HPLC. CAS No. 1164462-05-8. Molecular formula: C23H26N2O4. Mole weight: 394.46.
TG4-155 is a potent, brain-permeant and selective EP2 receptor antagonist with a K i of 9.9 nM [1] [2]. TG4-155 shows low nanomolar antagonist activity against only EP2 and DP1 [1]. TG4-155 has an EP2 Schild K B of 2.4 nM and displays 550-4750-fold selectivity for EP2 over EP1, EP3, EP4 and IP, but only 14-fold selectivity against the DP1 receptor [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1164462-05-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-18971.
TG53
TG53 is a novel inhibitor of tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction. Group: Biochemicals. Grades: Highly Purified. CAS No. 946369-04-6. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C21H22ClN5O2, Molecular Weight: 411.88. US Biological Life Sciences.
Worldwide
TG6-10-1
TG6-10-1, a potent and selective antagonist for the prostaglandin E2 receptor subtype EP2, has been shown antagonist activity at human EP2 receptor expressed in rat C6 cells. It shows low-nanomolar antagonist activity against EP2 (>300-fold selectivity ov. Synonyms: (E)-N-[2-[2-(trifluoromethyl)indol-1-yl]ethyl]-3-(3,4,5-trimethoxyphenyl)prop-2-enamideTG6-10-1; TG 6-10-1; TG-6-10-1; TP6101; TP-6101; TP 6101. CHEMBL32642041415716-58-3C23H23F3N2O4BDBM50016950AKOS0274399 55CS-4637; AK-499428; HY-16978; CS 4637; AK 499428; HY 16978; CS4637; AK499428; HY16978(E)-N-(2-(2-(Trifluoromethyl)-1H-indol-1-yl)ethyl)-3-(3,4,5-trime. CAS No. 1415716-58-3. Molecular formula: C23H23F3N2O4. Mole weight: 448.43.
TG6-129
TG6-129 is an antagonist of the EP2 receptor, suppressing PGE2-induced elevation of cAMP in cells expressing EP2 with IC50 value of 1.6 μM. It reduces the expression of COX-2, IL-1β, IL-12, IL-23, IL-6, and TNF-α induced by the EP2-selective agonist butaprost in P388D1 macrophages. Synonyms: SID 17503974; (E)-N-[[4-[(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl]carbamothioyl]-3-(4-fluorophenyl)prop-2-enamide. Grades: ≥98%. CAS No. 1164464-14-5. Molecular formula: C20H18FN5O3S3. Mole weight: 491.6.
Tgf-alpha
Tgf-alpha. Uses: Designed for use in research and industrial production. Additional or Alternative Names: HUMAN TRANSFORMING GROWTH FACTOR ALPHA;HUMAN TGF-A;HUMAN TGF-ALPHA;H-VAL-VAL-SER-HIS-PHE-ASN-LYS-CYS-PRO-ASP-SER-HIS-THR-GLN-TYR-CYS-PHE-HIS-GLY-THR-CYS-ARG-PHE-LEU-VAL-GLN-GLU-GLU-LYS-PRO-ALA-CYS-VAL-CYS-HIS-SER-GLY-TYR-VAL-GLY-VAL-ARG-CYS-GLU-HIS-ALA-A. Product Category: Heterocyclic Organic Compound. CAS No. 89899-53-6. Molecular formula: C244H367N71O71S6. Mole weight: 5623.35. Product ID: ACM89899536. Alfa Chemistry ISO 9001:2015 Certified. Categories: TGF alpha.
TGF α (1-50) (rat)
TGF α (1-50) (rat) was originally identified as an agent that can reversibly confer a transformed phenotype on normal non-tumor cells, such as normal rat renal fibroblasts. This activity requires the presence of transforming growth factor-β (TGF-β), which enhances the effects of TGF-α through a separate receptor. TGF-α is synthesized by monocytes, keratinocytes and a variety of tissues and tumors. (approx. ED50 = 0.2 ng/mL). Synonyms: H-Val-Val-Ser-His-Phe-Asn-Lys-Cys-Pro-Asp-Ser-His-Thr-Gln-Tyr-Cys-Phe-His-Gly-Thr-Cys-Arg-Phe-Leu-Val-Gln-Glu-Glu-Lys-Pro-Ala-Cys-Val-Cys-His-Ser-Gly-Tyr-Val-Gly-Val-Arg-Cys-Glu-His-Ala-Asp-Leu-Leu-Ala-OH (Disulfide bridge: Cys8-Cys21, Cys16-Cys32, Cys34-Cys43); Transforming Growth Factor-α (1-50) from rat. CAS No. 89899-53-6. Molecular formula: C244H361N71O71S6. Mole weight: 5617.38.
TGF-beta 3-E. coli human
recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
TGFβ-IN-2
TGFβ-IN-2 (Compound 9d) inhibits TGF-β-induced total collagen accumulation in NRK-49F cells with the IC 50 of 4.31 μM. TGFβ-IN-2 suppresses the TGF-β-induced protein expression of COL1A1, α-SMA, and p-Smad3 in vitro. TGFβ-IN-2 can be used as a potential effective compound for anti-fibrosis in vivo by oral administration [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2387678-02-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-146434.
TGFβ-IN-5
TGFβ-IN-5(Compd 12) is a TGFβ inhibitor useful for the study of fibroproliferative diseases associated with TGF-β signaling [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 259870-32-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128437.
TGF-beta receptor type-2 (131-139)
TGF-beta receptor type-2 (131-139) is a truncated fragment of TGF-beta receptor type-2. TGF-beta receptor type-2 is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. Synonyms: Transforming Growth Factor Beta Receptor 2 (131-139); TGF-Beta Type II Receptor (131-139).
TGF-beta/Smad Compound Library
A unique collection of 180 TGF-beta/Smad signaling targeted compounds for high throughput and high content screening; - Bioactivity and safety confirmed by pre-clinical research and clinical trials; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L4100. Categories: TGF-beta/Smad Compounds Libraries.
TGFBR1-IN-2
TGFBR1-IN-2 (Compound AQA) is a TGFBR1 inhibitor and an antibacterial agent. TGFBR1-IN-2 is a substrate for cytochrome P450s. TGFBR1-IN-2 contains the pyridyl-6-methyl moiety necessary for Mycobacterium tuberculosis inhibition and has potent inhibitory activity against non-replicating and persistent Mycobacterium tuberculosis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 733806-89-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164793.
TGR-1202 hydrochloride is the hydrochloride salt of TGR-1202.TGR-1202, also known as RP5264, is a highly specific, orally available, PI3Kdelta inhibitor which is approximately 1000 -fold selective over alpha isoform, >30-50 fold over beta isoform and >15-. Synonyms: RP5264 hydrochloride; TGR1202 hydrochloride; RP 5264 hydrochloride; TGR 1202 hydrochloride; RP-5264 hydrochloride; TGR-1202 hydrochloride. CAS No. 1532533-78-0. Molecular formula: C31H25ClF3N5O3. Mole weight: 608.01.
TGR5
A potent TGR5(GPCR19) agonist that showed improved potency in the U2-OS cell assay (pEC50 = 6.8) and in melanophore cells (pEC50 = 7.5). Synonyms: TGR5; TGR 5; TGR-5; TGR5 Receptor Agonist; MDK00245; MDK-00245; MDK 00245. CAS No. 1197300-24-5. Molecular formula: C18H14Cl2N2O2. Mole weight: 361.222.