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| Product | Description | |
|---|---|---|
| TGF?R1 (80-end), active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. |  |
| TGF?R1 (80-end), GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| TGF?R2 (190-end), active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| TGN 020 | TGN 020. Group: Biochemicals. Grades: Purified. CAS No. 51987-99-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| TGN 020 | TGN 020 is a derivative of thiadiazole and an aquaporin 4 (AQP4) channel blocker (IC50 = 3.1 μM). TGN 020 increases regional cerebral blood flow and reduces ischemia-induced brain edema in mice. Synonyms: TGN-020; TGN 020; TGN020; N-1,3,4-Thiadiazol-2-yl-3-pyridinecarboxamide; 2-(Nicotinamido)-1,3,4-thiadiazole. Grades: ≥99% by HPLC. CAS No. 51987-99-6. Molecular formula: C8H6N4OS. Mole weight: 206.22. |  |
| TGN-020 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| TGN-020 | TGN-020 is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 ?M[1][2]. TGN-020 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[3].TGN-020 alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats[4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 51987-99-6. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-W008574. |  |
| TGN-020 sodium | TGN-020 sodium is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 ?M[1][2]. TGN-020 sodium is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[3]. TGN-020 sodium alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats[4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1313731-99-5. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-W008574A. | |
| TGR-1202 hydrochloride | TGR-1202 hydrochloride is the hydrochloride salt of TGR-1202.TGR-1202, also known as RP5264, is a highly specific, orally available, PI3Kdelta inhibitor which is approximately 1000 -fold selective over alpha isoform, >30-50 fold over beta isoform and >15-. Synonyms: RP5264 hydrochloride; TGR1202 hydrochloride; RP 5264 hydrochloride; TGR 1202 hydrochloride; RP-5264 hydrochloride; TGR-1202 hydrochloride. CAS No. 1532533-78-0. Molecular formula: C31H25ClF3N5O3. Mole weight: 608.01. | |
| TGR5 | A potent TGR5(GPCR19) agonist that showed improved potency in the U2-OS cell assay (pEC50 = 6.8) and in melanophore cells (pEC50 = 7.5). Synonyms: TGR5; TGR 5; TGR-5; TGR5 Receptor Agonist; MDK00245; MDK-00245; MDK 00245. CAS No. 1197300-24-5. Molecular formula: C18H14Cl2N2O2. Mole weight: 361.222. | |
| TGR5 Receptor Agonist | TGR5 Receptor Agonist (CCDC), a potent Takeda G protein-coupled receptor 5 (TGR5; GPCR19) agonist, shows improved potency in the U2-OS cells and melanophore cells with pEC 50 s of 6.8 and 7.5, respectively. TGR5 Receptor Agonist can induce peripheral and central hypersensitivity to bladder distension in mice, and increase intracellular Ca 2+ concentration. TGR5 Receptor Agonist can also reduces food intake and improves insulin responsiveness, in diet-induced obese mice. TGR5 Receptor Agonist can be used to research diabetes, bladder hypersensitivity and anti-obesity [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CCDC. CAS No. 1197300-24-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14229. | |
| TGR5 Receptor Agonist (3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethylisoxazole-4-carboxamide) | Cell-permeable, small molecule agonist of TGR5 G-protein coupled receptor. This agonist has shown to increase glucagon like peptide-1 (GLP-1) secretion from primary intestinal cells. Group: Biochemicals. Alternative Names: 3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethylisoxazole-4-carboxamide. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| TGR5 Receptor Agonist, Cpd23g ( (4-cyclopropyl-3, 4-dihydroquinoxalin-1 (2H) -yl) (4- (2, 5-dimethylphenoxy) pyridin-3-yl) methanone, Bile Acid Receptor GPBAR-1 Agonist, Bile Acid Receptor Agonist, G Protein-coupled Bile Acid Receptor 1 Agonist) | A cell-permeable, orally available, phenoxypyrimidine carboxamide derivative that acts as a highly potent and selective agonist of Protein coupled receptor TGR5 (EC50 = 720 pM and 6.2nM for human and mouse TGR5, respectively). Does not exhibit any significant affinity towards other related targets such as GPR40, GPR119, and GPR120. Shown to increase glucagon-like peptide-1 (GLP-1) secretion in a dose-dependent manner and significantly reduce blood glucose levels in db/db mice following a single oral dose (50mg/kg). Exhibits desirable pharmacokinetic properties in rodent models (t½ = 1.5h, Cmax = 56ng/ml; and AUC = 147ng.h/ml following an oral dose of 5mg/kg). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| TGX-115, PI3K Inhibitor (8-(2-Methylphenoxy)-2-(4-morphonilyl)-4(1H)-quinolinone) | Cell-permeable. A potent and selective inhibitor of PI 3-K isoforms p110b/p110e (IC?? p110b=0.13uM, p110e=0.63uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 351071-62-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| TGX-221 | TGX-221 is a potent, selective, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit. Recent studies showed that TGX-221 has antiproliferative activity against PTEN-deficient tumor cell lines including prostate cancers. Synonyms: TGX221; TGX 221; 7-methyl-2-morpholino-9-(1-(phenylamino)ethyl)-4H-pyrido[1,2-a]pyrimidin-4-one. Grades: 98%. CAS No. 663619-89-4. Molecular formula: C21H24N4O2. Mole weight: 364.449. | |
| TGX-221 | TGX-221 is a potent, selective, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, used for cancer treatment. Uses: Scientific research. Group: Signaling pathways. CAS No. 663619-89-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10114. | |
| TGX-221, PI3K Inhibitor (±)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)-pyrido[1,2-a]-pyrimidin-4-one) | Cell-permeable. A potent, selective and ATP-competitive inhibitor of PI 3-kinase b (IC?? = 5nM for p110b). Inhibits other PI3K isoforms at higher concentrations (IC?? = 0.1uM for p110e, 5uM for p110a, and 3.5uM for p110g). Group: Biochemicals. Grades: Highly Purified. CAS No. 663619-89-4. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| TH1020 | TH1020 is a potent and selective toll-like receptor 5 (TLR5)/flagellin complex antagonist with an IC50 of 0.85 ?M. TH1020 inhbits flagellin-induced TLR5 signaling. TH1020 is inactive against TLR2, TLR3, TLR4, TLR7 and TLR8[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1841460-82-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116961. | |
| TH1020 | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| TH 1020 | TH 1020 is a toll-like receptor (TLR) 5/Flagellin complex antagonist (IC50 = 0.85 μM). TH 1020 competes with flagellin for TLR5 binding to inhibit the downstream TNF-α signaling pathways. Synonyms: TH1020; TH-1020; TH 1020; 4-[[4-(Phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine. Grades: ≥98% by HPLC. CAS No. 1841460-82-9. Molecular formula: C23H15N7S2. Mole weight: 453.54. | |
| TH10785 | TH10785 is a DNA glycosylase 1 (OGG1) activator, TH10785 can interact with the phenylalanine-319 and glycine-42 amino acids of OGG1 and increase the enzyme activity, generates ?, ?-lyase enzymatic function. TH10785 can control the catalytic activity mediated by a nitrogen base within its molecular structure. TH10785 can be used for the research of various diseases and aging connected with DNA oxidative lesions[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1002801-51-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147313. | |
| TH1217 | TH1217 (ZINC1775962367) is a potent and selective dCTPase pyrophosphatase 1 (dCTPase) inhibitor, with an IC50 of 47 nM. TH1217 enhances the cytotoxic effect of cytidine analogues in leukemia cells. TH1217 also could modulate SARS-Cov-2 interactors, so it shows activity of against COVID-19[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ZINC1775962367. CAS No. 1862212-48-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135909. | |
| TH 1217 | TH 1217 is a potent dCTPase pyrophosphatase 1 inhibitor with IC50 value of 47 nM. Synonyms: 2-[4-[[5,6-Dichloro-2-methyl-4-nitro-1H-benzo[d]-imidazol-1-yl]methyl]phenyl]-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione. Grades: ≥98% by HPLC. CAS No. 1862212-48-3. Molecular formula: C20H17BCl2N4O6. Mole weight: 491.09. | |
| TH1834 | TH1834 is a specific Tip60 (KAT5) histone acetyltransferase (HAT) inhibitor. TH1834 induces apoptosis and increases DNA damage in breast cancer. TH1834 does not affect the activity of related histone acetyltransferase MOF. Anticancer activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2108830-08-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123604. | |
| TH 1834 | TH 1834 is a Tip60 histone acetyltransferase inhibitor. TH 1834 causes apoptosis and increases unrepaired DNA damage (following ionizing radiation treatment) in breast cancer cells, yet not control cell lines or affect the activity of related HAT MOF. Synonyms: TH 1834; TH1834; TH-1834; 2-[5- (4-{[ (2-phenylethyl) ({4-[4- (pyrrolidin-1-ylmethyl) phenoxy]butyl}) amino]methyl}phenyl) -2H-1, 2, 3, 4-tetrazol-2-yl]acetic acid. Grades: 99%. Molecular formula: C33H40N6O3.2HCl. Mole weight: 641.63. | |
| TH-237A | TH-237A(meso-GS 164) is a novel neuroprotective agent exhibiting favorable permeation across the blood brain barrier. Synonyms: TH237A; TH 237A; TH237A. mesoGS 164. Grades: 0.98. CAS No. 935467-97-3. Molecular formula: C18H17F2NO3. Mole weight: 333.33. | |
| TH257 | TH257 is a Potent and selective allosteric LIMK 1/2 inhibitor. Uses: Designed for use in research and industrial production. Additional or Alternative Names: TH257; TH-257; TH 257. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2244678-29-1. Molecular formula: C24H26N2O3S. Mole weight: 422.54. Purity: >98%. IUPACName: N-Butyl-4-[(phenylamino)sulfonyl]-N-(phenylmethyl)benzamide. Canonical SMILES: O=C(N(CCCC)CC1=CC=CC=C1)C2=CC=C(S(=O)(NC3=CC=CC=C3)=O)C=C2. Product ID: ACM2244678291. Alfa Chemistry ISO 9001:2015 Certified. Categories: TH 257 (MN). |  |
| TH-257 | TH-257 is an effective inhibitor of LIMK1 and LIMK2. The IC50 values of LIMK1 and LIMK2 are 84 nM and 39 nM, respectively, and can be used as a chemical probe for LIMK1 and LIMK2. Synonyms: TH 257; TH257; N-Butyl-4-[(Phenylamino)Sulfonyl]-N-(Phenylmethyl)Benzamide; BCP31775; EX-A4475. Grades: 98%. CAS No. 2244678-29-1. Molecular formula: C24H26N2O3S. Mole weight: 422.5. | |
| TH-257 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| TH-263 | TH-263 is a diarylsulfonamide derivative and can be used as a control for inactive analogs of TH-257, TH-255 and TH-251. Synonyms: TH263; Oprea1_207287; BCP32731; TH 263. Grades: 98%. CAS No. 313520-94-4. Molecular formula: C21H20N2O3S. Mole weight: 380.5. | |
| TH-263 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| TH287 | TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM. Synonyms: TH 287; TH-287. Grades: 98%. CAS No. 1609960-30-6. Molecular formula: C11H10Cl2N4. Mole weight: 269.13. | |
| TH287 hydrochloride | TH287 hydrochloride, with potent anti-cancer property, is a novel inhibitor of the MTH1 protein which is required for cancer cell survival and is overexpressed in cancer cells. IC50: MTH1 (NUDT1)= 0.8 nM. Synonyms: 6-(2,3-dichlorophenyl)-4-N-methylpyrimidine-2,4-diamine;hydrochloride; TH287 (hydrochloride); TH 287 hydrochloride; TH-287 hydrochloride. CAS No. 1638211-05-8. Molecular formula: C11H11Cl3N4. Mole weight: 305.59. | |
| TH287 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| TH34 | TH34 is a HDAC inhibitor with selectivity for HDAC6, 8 and 10. It has been shown to induce DNA damage and G2/M phase cell cycle arrest in neuroblastoma cell lines as well as primary neuroblastoma cells, suggesting that it is identified as a potential antineoplastic agent. Synonyms: 3-(benzylamino)-N-hydroxy-4-methylbenzamide. CAS No. 2196203-96-8. Molecular formula: C15H16N2O2. Mole weight: 256.30. | |
| TH5427 | TH5427 is a promising, targeted inhibitor that can be used to further study NUDT5 activity and ADP-ribose metabolism. TH5427, blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells. NUDT5 is recently identified as a rheostat of hormone-dependent gene regulation and proliferation in breast cancer cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2253744-56-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125209. | |
| TH 5427 hydrochloride | TH 5427 is a potent nudix hydrolase 5 (NUDT5) inhibitor with IC50 value of 29 nM, displaying >650-fold selectivity for NUDT5 over NUDT1/MTH1. Synonyms: 7-[[5-(3,4-Dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-1,3-dimethyl-8-(piperazine-1-yl)-1H-purine-2,6-dione hydrochloride. Grades: ≥98% by HPLC. Molecular formula: C20H20Cl2N8O3·HCl. Mole weight: 527.79. | |
| TH5487 | TH5487 is a potent 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC50 of 342 nM. TH5487 stops OGG1 from recognizing its DNA substrate, inhibits DNA repair and modifies OGG1 chromatin dynamics, which results in the inhibition of proinflammatory pathway genes[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2304947-71-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-125276. | |
| TH 5487 | TH 5487 is a selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with IC50 value of 342 nM. It inhibits OGG1 binding to 8-oxoG in DNA, suppressing proinflammatory gene expression in TNF-α stimulated lung epithelial cells in vitro, and also inhibiting proinflamatory gene expression and neutrophil recruitment in TNF-α-challenged mouse lungs in vivo. Synonyms: 4-(4-Bromo-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-N-(4-iodophenyl)-1-piperidinecarboxamide. Grades: ≥98% by HPLC. CAS No. 2304947-71-3. Molecular formula: C19H18BrIN4O2. Mole weight: 541.18. | |
| TH588 | TH588 is a potent inhibitor of human 7,8-Dihydro-8-oxoguaninetriphosphatase MTH1 (NUDT1) with an IC50 value of 5 nM and good metabolic stability. Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA replication. TH588 a first-in-class nudix hydrolase family inhibitor that potently and selectively engages and inhibits the MTH1 protein in cells. Protein co-crystal structures demonstrate that the inhibitor binds in the active site of MTH1. Uses: Designed for use in research and industrial production. Additional or Alternative Names: TH588; TH-588; TH 588. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1609960-31-7. Molecular formula: C13H12Cl2N4. Mole weight: 295.17. Purity: >98%. IUPACName: N4-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine. Canonical SMILES: NC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC3CC3)=N1. Product ID: ACM1609960317. Alfa Chemistry ISO 9001:2015 Certified. Categories: TH 88 (MN). | |
| TH588 | TH588 is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC50= 5 nM). Uses: Scientific research. Group: Signaling pathways. CAS No. 1609960-31-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12814. | |
| TH588 | TH588 selectively kill U2OS and other cancer cell lines with less toxic to several primary or immortalized cells. Synonyms: TH588; TH 588; TH-588. Grades: >98%. CAS No. 1609960-31-7. Molecular formula: C13H12Cl2N4. Mole weight: 295.17. | |
| TH588 hydrochloride | TH588 hydrochloride, with potent anti-cancer property, is a novel inhibitor that highly selectively targets MTH1 protein (IC50= 5 nM) which is required for cancer cell survival and is overexpressed in cancer cells. Synonyms: 4-N-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine;hydrochloride; TH588 (hydrochloride); TH-588 hydrochloride; TH 588 hydrochloride; N4-Cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine hydrochloride; 1640282-30-9. CAS No. 1640282-30-9. Molecular formula: C13H13Cl3N4. Mole weight: 331.63. | |
| TH588 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| TH-6 | TH-6 is a potent HDAC inhibitor with IC 50 s of 0.115, 0.135, 0.242, 0.138, 2.120 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively. TH-6 inhibits cell migration and invasion. TH-6 induces apoptosis and cell cycle arrest at G2/M phase. TH-6 shows anti-tumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3031349-25-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149029. | |
| TH9402 | TH9402, a 4,5-dibromorhodamine derivative, is a novel photo-sensitizer. PDT using TH9402 triggers a caspase-dependent intrinsic apoptotic pathway. TH9402 offers an excellent potential as an ex vivo photodynamic purging agent for autologous transplantation in MM and BC treatment. Synonyms: TH9402; TH-9402; TH 9402; Xanthylium, 3,6-diamino-4,5-dibromo-9-[2-(methoxycarbonyl)phenyl]-, chloride (1:1). CAS No. 174230-05-8. Molecular formula: C21H15Br2ClN2O3. Mole weight: 538.62. | |
| TH9619 | TH9619 is a potent inhibitor of dehydrogenase and cyclohydrolase activities in both MTHFD1 and MTHFD2 with a IC50 value of 47 nM, and selectively kills cancer cells. TH9619 induces apoptosis by blocking the S phase. TH9619 has antitumor activity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2379556-22-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-155950. | |
| Thailanstatin A | Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding linker-less ADC[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1426953-21-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-129589. | |
| Thailanstatin A | Thailanstatin A is a splicesosome inhibitor that acts via suppressing RNA-polymerase II. It is effective against cancers, and can be used as a payload for ADCs. Synonyms: 1,6-Dioxaspiro[2.5]octane-5-acetic acid, 7-[(1E,3E)-5-[(2S,3S,5R,6R)-5-[[(2Z,4S)-4-(acetyloxy)-1-oxo-2-penten-1-yl]amino]tetrahydro-3,6-dimethyl-2H-pyran-2-yl]-3-methyl-1,3-pentadien-1-yl]-8-hydroxy-, (3R,5S,7R,8R)-. Grades: 95%. CAS No. 1426953-21-0. Molecular formula: C28H41NO9. Mole weight: 535.63. | |
| Thailanstatin B | Thailanstatin B is a pre-mRNA splicing inhibitor. Thailanstatin B is used as a cytotoxin for ADCs. Synonyms: EX-A5053. CAS No. 1426953-23-2. Molecular formula: C28H42ClNO9. Mole weight: 572.1. | |
| Thailanstatin C | Thailanstatin C is an antiproliferative agent and pre-mRNA splicing inhibitor (IC50 = 6.84 μM) from Burkholderia thailandensis MSMB43. Synonyms: (1S,5R)-1,5-Anhydro-1-(carboxymethyl)-3-C-(chloromethyl)-2-deoxy-5-{(1E,3E)-5-[(2S,3S,5R,6R)-5-{[(2Z,4S)-4-(isobutyryloxy)-2-pentenoyl]amino}-3,6-dimethyltetrahydro-2H-pyran-2-yl]-3-methyl-1,3-pentadien-1-yl}-D-erythro-pentitol; D-arabino-Heptonic acid, 3,7-anhydro-5-C-(chloromethyl)-2,4-dideoxy-7-C-[(1E,3E)-3-methyl-5-[(2S,3S,5R,6R)-tetrahydro-3,6-dimethyl-5-[[(2Z,4S)-4-(2-methyl-1-oxopropoxy)-1-oxo-2-penten-1-yl]amino]-2H-pyran-2-yl]-1,3-pentadien-1-yl]-, (7R)-. Grades: ≥95%. CAS No. 1426953-24-3. Molecular formula: C30H46ClNO9. Mole weight: 600.14. | |
| Thailanstatin D | Thailanstatin D inhibits AR-V7 gene splicing by interfering the interaction between U2AF65 and SAP155 and preventing them from binding to polypyrimidine tract located between the branch point and the 3' splice site. Thailanstatin D exhibits a potent tumor inhibitory effect on human CRPC xenografts leading to cell apoptosis. Synonyms: Spliceostatin C. CAS No. 1609105-89-6. Molecular formula: C28H41NO8. Mole weight: 519.63. | |
| thalianol synthase | This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. Group: Enzymes. Synonyms: (S)-2,3-epoxysqualene mutase (cyclizing, thalianol-forming). Enzyme Commission Number: EC 5.4.99.31. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5572; thalianol synthase; EC 5.4.99.31; (S)-2,3-epoxysqualene mutase (cyclizing, thalianol-forming). Cat No: EXWM-5572. |  |
| Thalicarpine | Thalicarpine is a natural aporphine benzylisoquinoline vinca alkaloid with antineoplastic activity. Thalicarpine binds to and inhibits p-glycoprotein, the multidrug resistance efflux pump. Thalicarpine also induces single-strand breaks in DNA and arrests cancer cells at the G2/M and G1 phase of the cell cycle. Synonyms: Thaliblastine; Taliblastine; Taliblastin; NY-IV-34-1; NSC-68075; NSC 68075; (S)-9-(2-(((S)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-4,5-dimethoxyphenoxy)-1,2,10-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline. CAS No. 5373-42-2. Molecular formula: C41H48N2O8. Mole weight: 696.83. | |
| Thalidomide | Recruits SALL4 to cereblon-CRL4 ubiquitin ligase. Uses: Angiogenesis inhibitors; immunosuppressive agents; leprostatic agents; teratogens. Synonyms: alphaphthalimidoglutarimide. Nphthaloylglutamimide; Nphthalylglutamic acid imide. US brand names: Synovir; Thalomid. Foreign brand names: Contergan; Distaval; Kevadon; Neurosedyn; Pantosediv; Sedoval K17; Softenon Talimol; Abbreviation: THAL. Grades: ≥99% (HPLC). CAS No. 50-35-1. Molecular formula: C13H10N2O4. Mole weight: 258.23. | |
| Thalidomide | Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a K d of ?250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide can work as molecular glue to potentiate substrate. Uses: Scientific research. Group: Signaling pathways. CAS No. 50-35-1. Pack Sizes: 10 mM * 1 mL; 200 mg; 500 mg. Product ID: HY-14658. | |
| Thalidomide (2-(2,6-Dioxo-3-piperidinyl)-1H-iso-indole-1,3(2H)-dione) | Inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative. Group: Biochemicals. Alternative Names: 2-(2,6-Dioxo-3-piperidinyl)-1H-iso-indole-1,3(2H)-dione. Grades: Highly Purified. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
| Thalidomide 4'-ether-alkylC2-amine hydrochloride | Thalidomide 4'-ether-alkylC2-amine hydrochloride is a synthetic E3 ligand-linker conjugate containing a cereblon ligand based on Thalidomide and a short C2 alkyl linker with terminal amine for covalent binding, as a part of a variety of functionalized PROTAC molecules for binding to a target protein ligand. Synonyms: Thalidomide - linker 6. Grades: ≥95% by HPLC. CAS No. 2341840-99-9. Molecular formula: C15H16ClN3O5. Mole weight: 353.76. | |
| Thalidomide 4-fluoride | Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966)[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cereblon ligand 4; E3 ligase Ligand 4. CAS No. 835616-60-9. Pack Sizes: 1 g; 5 g. Product ID: HY-41547. | |
| Thalidomide-4-O-C4-NH2 hydrochloride | Thalidomide-4-O-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide (HY-14658) based cereblon ligand and a linker used in PROTAC technology. Uses: Scientific research. Group: Signaling pathways. CAS No. 2376990-29-1. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-130948B. | |
| Thalidomide-5-OH | Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 64567-60-8. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g; 10 g; 25 g. Product ID: HY-23095. | |
| Thalidomide-5-PEG3-NH2 hydrochloride | Thalidomide-5-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2761385-81-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-138786A. | |
| Thalidomide-d4 (2-(2,6-Dioxo-3-piperidinyl)-1H-iso-indole-1,3(2H)-dione-d4) | Labelled Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative. Group: Biochemicals. Alternative Names: 2-(2,6-Dioxo-3-piperidinyl)-1H-iso-indole-1,3(2H)-dione-d4. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Thalidomide-O-amido-C6-NH2 (TFA) | Thalidomide-O-amido-C6-Amine trifluoroacetate is a PROTAC block consist of Thalidomide linked to alkyl with Amine functional group for conjugation reactions. Synonyms: Thalidomide-O-amido-C6-NH2 (TFA); Cereblon Ligand-Linker Conjugates 11 (TFA); E3 Ligase Ligand-Linker Conjugates 25 (TFA); Thalidomide-O-amido-C6-Amine Trifluoroacetate; N-(6-aminohexyl)-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide;2,2,2-trifluoroacetic acid. CAS No. 1950635-14-9. Molecular formula: C23H27F3N4O8. Mole weight: 544.48. | |
| Thalidomide-O-amido-C8-NH2 (TFA) | Thalidomide-O-amido-C8-NH2 (TFA) is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology. Synonyms: E3 Ligase Ligand-Linker Conjugates 17. CAS No. 1950635-16-1. Molecular formula: C25H31F3N4O8. Mole weight: 572.53. | |
| Thalidomide-O-amido-PEG2-C2-NH2 TFA | Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cereblon Ligand-Linker Conjugates 10 TFA; E3 Ligase Ligand-Linker Conjugates 24 TFA. CAS No. 1957235-75-4. Pack Sizes: 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-112617A. | |
| Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride | Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2245697-84-9. Pack Sizes: 25 mg; 100 mg. Product ID: HY-107440A. | |
| Thalidomide-O-amido-PEG3-C2-NH2 TFA | Thalidomide-O-amido-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cereblon Ligand-Linker Conjugates 3 TFA; E3 ligase Ligand-Linker Conjugates 14 TFA. CAS No. 1957236-21-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103611. | |
| Thalidomide-O-C4-NH2 hydrochloride | Thalidomide-O-C4-NH2 hydrochloride is a synthetic E3 ligand-linker conjugate containing a cereblon ligand based on Thalidomide and a C4 alkyl linker with terminal amine, as a part of a variety of functionalized PROTAC molecules for binding to a target protein ligand. Synonyms: Thalidomide-linker 9. Grades: ≥95% by HPLC. CAS No. 2376990-29-1. Molecular formula: C17H20ClN3O5. Mole weight: 381.81. | |
| Thalidomide-piperazine hydrochloride | Thalidomide-piperazine hydrochloride has the potential for the research of leprosy and multiple myeloma. Thalidomide-piperazine hydrochloride used as a tool in developmental biology leads to important discoveries in the biochemical pathways of limb development [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2228029-82-9. Pack Sizes: 25 mg; 50 mg. Product ID: HY-132971. | |
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