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| Product | Description | |
|---|---|---|
| VU 0364739 hydrochloride | VU 0364739 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1244640-48-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| VU0364770 | VU0364770 is a selective and potent positive allosteric modulator ( PAM ) of mGlu4. VU0346770 exhibits EC 50 s of 290 nM and 1.1 μM at rat mGlu4 and human mGlu4 receptor , respectively. VU0364770 exhibits antagonist activity at mGlu5 with a potency of 17.9 μM and PAM activity at mGlu6 with a potency of 6.8 μM. VU0364770 also possesses activity at MAO with K i values of 8.5 and 0.72 μM for human MAO-A and human MAO-B, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 61350-00-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100588. |  |
| VU 0364770 | VU 0364770. Group: Biochemicals. Grades: Purified. CAS No. 61350-00-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| VU0364770 hydrochloride | VU0364770 hydrochloride is a selective and potent positive allosteric modulator ( PAM ) of mGlu4. VU0346770 hydrochloride exhibits EC 50 s of 290 nM and 1.1 μM at rat mGlu4 and human mGlu4 receptor , respectively. VU0364770 hydrochloride exhibits antagonist activity at mGlu5 with a potency of 17.9 μM and PAM activity at mGlu6 with a potency of 6.8 μM. VU0364770 hydrochloride also possesses activity at MAO with K i values of 8.5 and 0.72 μM for human MAO-A and human MAO-B, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1414842-70-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100588A. | |
| VU 0365114 | VU 0365114. Group: Biochemicals. Grades: Purified. CAS No. 1208222-39-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| VU0405601 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| VU0420373 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| VU0463271 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| VU0463271 | VU0463271 is a selective KCC2 antagonist, with an IC50 of 61 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1391737-01-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110110. | |
| VU 0463271 | VU 0463271. Group: Biochemicals. Grades: Purified. CAS No. 1391737-01-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| VU0463597 | VU0463597, also known as ML-289, is a negative allosteric modulator of mGlu3 (IC50 = 0.66 μM) that displays 15-fold selectivity over mGlu2 and inactivity against mGlu5.1. Uses: Designed for use in research and industrial production. Additional or Alternative Names: VU0463597, VU 0463597, VU-0463597, ML-289, ML 289; ML289. Product Category: Others. Appearance: Solid powder. CAS No. 1382481-79-9. Molecular formula: C22H23NO3. Mole weight: 349.43. Purity: >98%. IUPACName: [(3R)-1-({4-[2-(4-methoxyphenyl)ethynyl]phenyl}carbonyl)piperidin-3-yl]methanol. Canonical SMILES: OC[C@H]1CN(C(C2=CC=C(C#CC3=CC=C(OC)C=C3)C=C2)=O)CCC1. Product ID: ACM1382481799. Alfa Chemistry ISO 9001:2015 Certified. |  |
| VU0486321 | VU0486321 is a compound in a class of mGlu1 positive allosteric modulators (PAMs). VU0486321 maintains acceptable mGlu1 PAM potency, DMPK profile, CNS permeability, and mGluR selectivity. Uses: Scientific research. Group: Signaling pathways. CAS No. 1816301-67-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-118179. | |
| VU0486846 | VU0486846 is an orally active and selective muscarinic acetylcholine receptor M1 positive allosteric modulator (PAM) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1788055-11-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-121806. | |
| VU0529331 | VU0529331 is a modestly selective non-GIRK1-containing G protein-gated, inwardly-rectifying, potassium channel (non-GIRK1/X) activator, with EC50s of 5.1 μM and 5.2 μM for GIRK2 and GIRK1/2 in HEK293 cells, respectively, also effective on GIRK4 homomeric channel[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1286725-49-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112705. | |
| VU0650786 | VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM), with an IC50 of 392 nM. VU0650786 has antidepressant and anxiolytic activity in rodents[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1809085-30-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-108710. | |
| VU 10010 | VU 10010. Group: Biochemicals. Grades: Purified. CAS No. 633283-39-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| VU 152100 | VU 152100. Group: Biochemicals. Grades: Purified. CAS No. 409351-28-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| VU 1545 | VU 1545. Group: Biochemicals. Grades: Purified. CAS No. 890764-63-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| VU 29 | VU 29. Group: Biochemicals. Grades: Purified. CAS No. 890764-36-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| VU-29 | VU-29 is a positive allosteric modulator of metabotropic glutamate 5 (mGlu5) receptor ( EC 50 =9 nM and K i =244 nM for rmGluR5). VU-29 is selective for mGluR5 relative to other mGluR subtypes (EC 50 : rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 890764-36-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107508. | |
| VU590 | VU590 is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC 50 of 290 nM. VU590 also inhibits Kir7.1 , with an IC 50 of 8 μM. VU590 is not a good probe of ROMK function in the kidney [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 313505-85-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108595. | |
| VU 590 dihydrochloride | VU 590 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 313505-85-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| VU591 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| VU 591 hydrochloride | VU 591 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1315380-70-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| VU6005649 | VU6005649 is a CNS penetrant mGlu7/8 receptor agonist with EC50s of 0.65 ?M and 2.6 ?M for mGlu7 receptor and mGlu8 receptor, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 2137047-43-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107982. | |
| VU6036720 | VU6036720 is a potent and specific in vitro inhibitor of Kir4.1/5.1. VU6036720 can inhibit Kir4.1/5.1 channels with an IC 50 value of 0.24 μM. VU6036720 can be used for the research of brain and kidney [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3026597-12-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-148304. | |
| VUAA1 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Vudalimab | Vudalimab is a potent dual PD-1 and CTLA-4 inhibitor as a fully humanized bispecific monoclonal antibody. Vudalimab targets immune checkpoint receptors PD-1 and CTLA-4 and promotes tumor-selective T-cell activation [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2329669-72-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99166. | |
| VUF10166 | VUF10166 is a potent and high-affinity 5-HT 3 receptor antagonist, with K i values of 0.04 nM (5-HT 3 A) and 22 nM (5-HT 3 AB). VUF10166 inhibits 5-HT-induced responses at 5-HT 3 A and 5-HT 3 AB receptors at nanomolar concentrations. At 5-HT 3 receptor , VUF10166 at higher concentrations also acts as a partial agonist, with an EC 50 of 5.2 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 155584-74-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100552. | |
| VUF 10166 | VUF 10166. Group: Biochemicals. Grades: Purified. CAS No. 155584-74-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| VUF 10460 | VUF 10460. Group: Biochemicals. Grades: Purified. CAS No. 1028327-66-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| VUF10661 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| VUF 11207 fumarate | VUF 11207 fumarate. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| VUF11207 fumarate | VUF11207 fumarate is a CXCR7 agonist that binds specifically to CXCR7. VUF11207 fumarate reduces CXCL12-mediated osteoclastogenesis and bone resorption by inhibiting ERK phosphorylation[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1785665-61-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110318. | |
| VUF11207 trifluoroacetate salt | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| VUF 5574 | VUF 5574. Group: Biochemicals. Grades: Purified. CAS No. 280570-45-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| VUF 5681 dihydrobromide | VUF 5681 dihydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 639089-06-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| VUF 8430 dihydrobromide | ?97% (NMR). Group: Fluorescence/luminescence spectroscopy. | |
| VUF 8430 dihydrobromide | VUF 8430 (dihydrobromide) is a potent and selective histamine H4 receptor agonist with a K i of 31.6 nM and an EC 50 of 50 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 100130-32-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-107555. | |
| VUF 8430 dihydrobromide | VUF 8430 dihydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 100130-32-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| vulcanization agents | vulcanization agents. Group: Polymers. |  |
| VULM 1457 | VULM 1457. Group: Biochemicals. Grades: Purified. CAS No. 228544-65-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Vulpinic acid | Vulpinic acid. Group: Biochemicals. Alternative Names: (a-E) -a- (3-Hydroxy-5-oxo-4-phenyl-2 (5H) -furanylidene) benzeneacetic Acid Methyl Ester. Grades: Highly Purified. CAS No. 521-52-8. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C19H14O5. US Biological Life Sciences. | Worldwide |
| VUN32779 | VUN32779, also known as 7-benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4H)-one is a chemical reagent for research use. Uses: Designed for use in research and industrial production. Additional or Alternative Names: VUN32779; VUN 32779; VUN-32779. Product Category: Others. Appearance: Solid powder. CAS No. 1616632-77-9. Molecular formula: C24H26N4O. Mole weight: 386.5. Purity: >98%. IUPACName: 7-benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4H)-one. Canonical SMILES: O=C1N(CC2=CC=CC=C2C)C3=NCCN3C4=C1CN(CC5=CC=CC=C5)CC4. Product ID: ACM1616632779. Alfa Chemistry ISO 9001:2015 Certified. | |
| VUN73874 | VUN73874, also known as GOT1 inhibitor 2c, is a glutamate-oxaloacetate transaminase 1 (GOT1)? inhibitor. This compound was first reported in Bioorg Med Chem Lett. 2018 Sep 1;28(16):2675-2678. Uses: Designed for use in research and industrial production. Additional or Alternative Names: GOT1 inhibitor 2c; VUN73874; VUN-73874; VUN 73874. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 732973-87-4. Molecular formula: C19H19ClN4O. Mole weight: 354.84. Purity: >98%. IUPACName: N-(4-Chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide. Canonical SMILES: O=C(N1CCN(C2=CC=CC3=C2C=CN3)CC1)NC4=CC=C(Cl)C=C4. Product ID: ACM732973874. Alfa Chemistry ISO 9001:2015 Certified. | |
| Vunakizumab | Vunakizumab (Anti-Human IL17A Recombinant Antibody) is a recombinant human IgGκ monoclonal antibody that targets IL-17A and inhibits its interaction with the IL-17 receptor. Vunakizumab can be used to study autoimmune diseases such as psoriatic arthritis, ankylosing spondylitis, multiple sclerosis and inflammatory arthritis [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Anti-Human IL17A Recombinant Antibody. CAS No. 1792181-33-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99335. | |
| VUT-MK142 | VUT-MK142 is a potent new cardiomyogenic synthetic agent promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes, which may be useful to differentiate stem cells into cardiomyocytes for cardiac repair [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1313491-22-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122610. | |
| VV116 | VV116, also known as JT001, is an oral drug candidate of nucleoside analog against SARS-CoV-2. VV116 is a deuterated, tri-isobutyrate ester prodrug of the RDV parent nucleoside, and is rapidly metabolized into the parent nucleoside (116-N1) in the body. 116-N1 is intracellularly converted to the nucleoside triphosphate active form, which would interfere with the function of RNA-dependent RNA polymerase of SARS-CoV-2, thus exerting antiviral effects (Fig. 1). VV116 showed potent activity against a panel of SARS-CoV-2 variants (alpha, beta, delta, and omicron) and excellent therapeutic efficacy in the mice model. Uses: Designed for use in research and industrial production. Additional or Alternative Names: VV116; VV 116; VV-116; JT001; JT-001; JT 001. Product Category: Others. Appearance: Solid powder. CAS No. 2647442-33-7. Molecular formula: C24H30DN5O7. Mole weight: 502.55. Purity: >98%. IUPACName: (2R,3R,4R,5R)-2-(4-amino-5-deuteropyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-cyano-5-((isobutyryloxy)methyl)tetrahydrofuran-3,4-diyl bis(2-methylpropanoate). Canonical SMILES: CC(C(OC[C@H]1O[C@](C#N)([C@@H]([C@@H]1OC(C(C)C)=O)OC(C(C)C)=O)C2=CC([2H])=C3N2N=CN=C3N)=O)C. Product ID: ACM2647442337. Alfa Chemistry ISO 9001:2015 Certified. | |
| Vv-AMP1 | Vv-AMP1 is an antibacterial peptide isolated from Vit is vinifera. It has activity against fungi. Synonyms: Arg-Thr-Cys-Glu-Ser-Gln-Ser-His-Arg-Phe-Lys-Gly-Thr-Cys-Val-Arg-Gln-Ser-Asn-Cys-Ala-Ala-Val-Cys-Gln-Thr-Glu-Gly-Phe-His-Gly-Gly-Asn-Cys-Arg-Gly-Phe-Arg-Arg-Arg-Cys-Phe-Cys-Thr-Lys-His-Cys. Molecular formula: C216H343N81O64S8. Mole weight: 5355.08. |  |
| VVD-130037 | VVD-130037 (BAY-3605349) is an orally active covalent activator of KEAP 1 (Kelch-like ECH-associated protein 1) with anti-tumor activity. VVD-130037 degrades NRF2 (nuclear factor-erythroid 2 p45-related factor 2), resulting in significant inhibition of tumor growth in advanced solid tumors[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY-3605349. CAS No. 3034880-93-5. Pack Sizes: 10 mM * 1 mL; 5 mg. Product ID: HY-159641. | |
| VVD-214 | VVD-214 is a synthetic lethal allosteric inhibitor of WRN helicase with an IC50 of 0.1316 μM. VVD-214 covalently binds to cysteine 727 of WRN and inhibits ATP hydrolysis and helicase activity. VVD-214 is potent in causing double-stranded DNA breaks, nuclear swelling, and cell death in high microsatellite instability (MSI) cancers[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RO7589831; VVD-133214. CAS No. 3026500-20-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158116. | |
| VX-11e | VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK with Ki < 2 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 896720-20-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14178. | |
| VX-561 | VX-561, also known as d9-ivacaftor, is an agonist of cystic fibrosis transmembrane conductance regulator (CFTR) channel developed for the treatment of cystic fibrosis. VX-561 is in a phase II clinical trial for safety and efficacy evaluation. Uses: Potential treatment of cystic fibrosis. Synonyms: CTP-656; N-(2-(tert-butyl)-5-hydroxy-4-(2-(methyl-d3)propan-2-yl-1,1,1,3,3,3-d6)phenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide; d9-ivacaftor. CAS No. 1413431-07-8. Molecular formula: C24H19D9N2O3. Mole weight: 401.55. | |
| VX-680 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| VX 702 | VX 702. Group: Biochemicals. Grades: Purified. CAS No. 479543-46-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| VX-702 | VX-702. Group: Biochemicals. Alternative Names: 6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide. Grades: Highly Purified. CAS No. 745833-23-2. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C19H12F4N4O2. US Biological Life Sciences. | Worldwide |
| VX-702 | VX-702 is a highly selective inhibitor of p38? MAPK, 14-fold higher potency against the p38? versus p38?[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 745833-23-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10401. | |
| VX 745 | VX 745 is a potent and selective inhibitor of p38α mitogen-activated protein (MAP) kinase. VX 745 is a potential anti-inflammatory agents. Studies suggest that VX 745 may be useful in the treatment of Werner syndrome. Group: Biochemicals. Alternative Names: 5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one. Grades: Highly Purified. CAS No. 209410-46-8. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| VX-745 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| VX-765 | VX-765. Group: Biochemicals. Alternative Names: N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-L-prolinamide; Belnacasan. Grades: Highly Purified. CAS No. 273404-37-8. Pack Sizes: 5mg. Molecular Formula: C24H33ClN4O6, Molecular Weight: 509. US Biological Life Sciences. | Worldwide |
| VX-809 (Lumacaftor) | VX-809 (Lumacaftor). Group: Biochemicals. Alternative Names: 3- [6- [ [ [1- (2, 2-Difluoro-1, 3-benzodioxol-5-yl) cyclopropyl] carbonyl] amino] -3-methyl-2-pyridinyl] benzoic Acid; Lumacaftor; VRT 826809. Grades: Highly Purified. CAS No. 936727-05-8. Pack Sizes: 50mg, 100mg, 250mg. Molecular Formula: C??H??F?N?O?, Molecular Weight: 452.51. US Biological Life Sciences. | Worldwide |
| VX-984 | VX-984 is an orally active, potent, selective and BBB-penetrated DNA-PK inhibitor. VX-984 efficiently inhibits NHEJ (non-homologous end joining) and increases DSBs (DNA double-strand breaks). VX-984 can be used for glioblastomas (GBM) and non-small cell lung cancer (NSCLC) research. VX-984 is a de novo deuterium[1][2][3]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: M9831. CAS No. 1476074-39-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19939S. | |
| VY-3-135 | VY-3-135 is a potent, orally active, and stable ACSS2 inhibitor with an IC50 value of 44 nM. VY-3-135 is specific to ACSS2 among the AcCoA synthetase family of enzymes. VY-3-135 does not inhibit ACSS1 or ACSS3 enzymatic activity. VY-3-135 can be used for the research of breast cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1824637-41-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145953. | |
| VY-3-135 | VY-3-135 is a potent ACSS2 inhibitor. VY-3-135 acts as a transition-state mimetic to block ACSS2 activity in vitro and in vivo. Pharmacologic inhibition of ACSS2 as a single agent impaired breast tumor growth. The aqueous solubility of VY-3-135 was 21.7 μM. The aqueous solubility of VY-3-135 was 21.7 μM. VY-3-135 is a potent low nanomolar inhibitor of ACSS2 in cancer cells in vitro. VY-3-135 potently inhibits ACSS2 dependent fatty acid metabolism but has no effect on gene expression in tumors. Uses: Designed for use in research and industrial production. Additional or Alternative Names: VY-3-135; VY3-135; VY 3-135; VY-3135; VY3135; VY 3135. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1824637-41-3. Molecular formula: C26H27N3O3. Mole weight: 429.52. Purity: >98%. IUPACName: (R)-1-Ethyl-2-(hydroxydiphenylmethyl)-N-(2-hydroxypropyl)-1H-benzo[d]imidazole-6-carboxamide. Canonical SMILES: O=C(C1=CC=C2C(N(CC)C(C(C3=CC=CC=C3)(O)C4=CC=CC=C4)=N2)=C1)NC[C@H](O)C. Product ID: ACM1824637413. Alfa Chemistry ISO 9001:2015 Certified. | |
| VZ185 | VZ185 is a potent, fast, and selective von Hippel-Lindau based dual degrader probe of BRD9 and BRD7 with DC50s of 4.5 and 1.8 nM, respectively. VZ185 is cytotoxic in EOL-1 and A-402 cells, with EC50s of 3 nM and 40 nM, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2306193-61-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114322. | |
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