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| Product | Description | |
|---|---|---|
| American Ginseng Root Powder | American Ginseng Root Powder. |  CA, FL & NJ |
| Americium dioxide | Americium dioxide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Americium dioxide, 12005-67-3. Product Category: Heterocyclic Organic Compound. CAS No. 12005-67-3. Molecular formula: AmO2. Mole weight: 275.060181 [g/mol]. Purity: 0.96. IUPACName: americium;oxygen(2-). Product ID: ACM12005673. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Ametantrone | Ametantrone (AM) is a topoisomerase II inhibitor leading to covalent cross-links in DNA of tumor cells. It is a synthetic 9,10-anthracenedione containing two (hydroxyethylamino)ethylamino residues at positions 1 and 4. Along with other anthraquinones and anthracyclines, it shares a polycyclic intercalating moiety and charged side chains that stabilize DNA binding. Synonyms: CI881; CI 881; CI-881; NSC196473; NSC 287513; NSC-196473; NSC 287513; 1,4-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione. CAS No. 64862-96-0. Molecular formula: C22H28N4O4. Mole weight: 412.49. |  |
| Ametantrone Acetate | Ametantrone is a topoisomerase II inhibitor of the anthrapyrazole family. It can cause covalent cross-links in DNA, so it can be used as a antineoplastic agent. Uses: Antineoplastic agent. Synonyms: CI-881; CI 881; CI881; NSC 287513; NSC-287513; NSC287513; 1,4-bis((2-((2-hydroxyethyl)amino)ethyl)amino)anthracene-9,10-dione diacetate. Grade: 98%. CAS No. 70711-40-9. Molecular formula: C26H36N4O8. Mole weight: 532.59. | |
| a-Methyl-2-piperidinemethanol | a-Methyl-2-piperidinemethanol. Group: Biochemicals. Alternative Names: 1-(2-Piperidyl)ethanol; 2- (1'-Hydroxyethyl) piperidine; Methyl(2-piperidyl)carbinol. Grades: Highly Purified. CAS No. 54160-32-6. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. Molecular Formula: C7H15NO. US Biological Life Sciences. |  Worldwide |
| a-Methyl-(3-benzyloxy)benzyl alcohol ≥97% (GC) | a-Methyl-(3-benzyloxy)benzyl alcohol ≥97% (GC). Group: Biochemicals. Grades: GC. Pack Sizes: 250mg, 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| a-Methyl-5-(2-thienylmethoxy)-1H-indole-3-ethanamine monohydrochloride | a-Methyl-5-(2-thienylmethoxy)-1H-indole-3-ethanamine monohydrochloride. Group: Biochemicals. Alternative Names: BW 723C86. Grades: Highly Purified. CAS No. 160521-72-2. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C16H19ClN2OS. US Biological Life Sciences. | Worldwide |
| a-Methyl-5H-[1]benzopyrano[2,3-b]pyridine-7-acetic acid | a-Methyl-5H-[1]benzopyrano[2,3-b]pyridine-7-acetic acid. Group: Biochemicals. Alternative Names: Pranoprofen ; (+/-)-Pranoprofen; 2-(5H-[1]-Benzopyrano[2,3-b]pyridin-7-yl)propionic acid. Grades: Highly Purified. CAS No. 52549-17-4. Pack Sizes: 5g, 10g, 25g, 50g, 100g. Molecular Formula: C15H13NO3. US Biological Life Sciences. | Worldwide |
| a-Methyl-5-pyrimidinemethanol | a-Methyl-5-pyrimidinemethanol. Group: Biochemicals. Alternative Names: 1-(Pyrimidin-5-yl)ethan-1-ol. Grades: Highly Purified. CAS No. 79691-74-0. Pack Sizes: 25mg, 50mg, 100mg, 250mg, 500mg. Molecular Formula: C6H8N2O. US Biological Life Sciences. | Worldwide |
| A-METHYLBENZYLZINC BROMIDE | A-METHYLBENZYLZINC BROMIDE. Group: Salt. Alternative Names: 85459-20-7, 498777_ALDRICH, |A-Methylbenzylzinc bromide solution, AKOS016018002, alpha-Methylbenzylzinc bromide solution, a-Methylbenzylzinc bromide 0.5 M in Tetrahydrofuran. CAS No. 85459-20-7. Product ID: bromozinc(1+); ethylbenzene. Molecular formula: 250.45. Mole weight: C8H9BrZn. C[CH-]C1=CC=CC=C1.[Zn+]Br. LCPVHNNFHPWFCI-UHFFFAOYSA-M. 96%. |  |
| a-Methyl cinnamic acid | a-Methyl cinnamic acid. Group: Biochemicals. Grades: Highly Purified. CAS No. 1199-77-5. Pack Sizes: 50g, 100g. Molecular Formula: C10H10O2. US Biological Life Sciences. | Worldwide |
| a-Methyl-D-4-Fluorophenylalanine 98+% (HPLC) | a-Methyl-D-4-Fluorophenylalanine 98+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 100mg, 250mg, 1g, 2.5g. US Biological Life Sciences. | Worldwide |
| a-Methyl-DL-phenylalanine 98+% (HPLC) | a-Methyl-DL-phenylalanine 98+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| a-Methyl-DL-phenylalanine methyl ester hydrochloride | a-Methyl-DL-phenylalanine methyl ester hydrochloride. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| a-Methyl-D,L-serine (D, L-a- (Hydroxymethyl) alanine) | A serine derivative. Used in the synthesis of constrained amino acid buildings blocks and their incorporation into biologically active peptidomimetics. Group: Biochemicals. Alternative Names: D, L-a- (Hydroxymethyl) alanine. Grades: Highly Purified. CAS No. 5424-29-3. Pack Sizes: 1g, 5g, 10g. US Biological Life Sciences. | Worldwide |
| a-Methyl-D,L-tryptophan, Methyl Ester | a-Methyl-D,L-tryptophan, Methyl Ester. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| a-Methyl-D,L-tyrosine | A tyrosine hydroxylase inhibitor. An antihypertensive in pheochromocytoma. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| a-Methyl-DL-valine 99+% | a-Methyl-DL-valine 99+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g, 100g. US Biological Life Sciences. | Worldwide |
| a-Methyl-D-phenylalanine | a-Methyl-D-phenylalanine. Group: Biochemicals. Alternative Names: a-Me-D-Phe-OH; (R)-2-Amino-2-methyl-3-phenylpropanoic acid. Grades: Highly Purified. CAS No. 17350-84-4. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. US Biological Life Sciences. | Worldwide |
| a-Methyl-D-phenylalanine 99+% (Chiral HPLC) | a-Methyl-D-phenylalanine 99+% (Chiral HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 250mg, 1g, 5g. US Biological Life Sciences. | Worldwide |
| a-Methyl-D-serine ((-)-2-Methyl-D-serine, (R)-(-)-2-Amino-3-hydroxy-2-methylpropionic Acid) | Melting Point: >260°C (dec). Group: Biochemicals. Alternative Names: (-)-2-Methyl-D-serine; (R)-(-)-2-Amino-3-hydroxy-2-methylpropionic Acid. Grades: Highly Purified. CAS No. 81132-44-7. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| a-Methyl-D-valine 98+% (NMR) | a-Methyl-D-valine 98+% (NMR). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 100mg, 250mg, 1g, 5g. US Biological Life Sciences. | Worldwide |
| a-Methylene-gamma-butyrolactone | a-Methylene-gamma-butyrolactone. Group: Biochemicals. Alternative Names: 3-Methylenedihydro-2(3H)-furanone; Tulipane. Grades: Highly Purified. CAS No. 547-65-9. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C5H6O2. US Biological Life Sciences. | Worldwide |
| a-Methyl-L-4-Fluorophenylalanine 98+% (HPLC) | a-Methyl-L-4-Fluorophenylalanine 98+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 100mg, 250mg, 1g, 2.5g. US Biological Life Sciences. | Worldwide |
| a-Methyl-L-phenylalanine 99+% | a-Methyl-L-phenylalanine 99+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 250mg, 1g, 5g. US Biological Life Sciences. | Worldwide |
| a-Methyl-L-phenylalanine methyl ester hydrochloride ≥97% (HPLC) | a-Methyl-L-phenylalanine methyl ester hydrochloride ≥97% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 250mg, 1g, 5g. US Biological Life Sciences. | Worldwide |
| a-Methyl-L-p-tyrosine (AMPT, Metyrosine,) | A tyrosine hydroxylase inhibitor. An antihypertensive in pheochromocytoma. Group: Biochemicals. Alternative Names: AMPT, Metyrosine. Grades: Highly Purified. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| a-Methyl-L-tryptophan | Atmosphere: Group: Biochemicals. Alternative Names: (-)-a--Methyltryptophan; a-Methyl-(S)-tryptophan; L-a-Methyltryptophan. Grades: Highly Purified. CAS No. 16709-25-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| a-Methyl-L-valine | a-Methyl-L-valine. Group: Biochemicals. Alternative Names: a-Me-L-Val-OH. Grades: Highly Purified. CAS No. 53940-83-3. Pack Sizes: 500mg, 1g, 2g, 5g. US Biological Life Sciences. | Worldwide |
| a-Methyl-L-valine 99+% (TLC) | a-Methyl-L-valine 99+% (TLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 250mg, 1g, 5g. US Biological Life Sciences. | Worldwide |
| a-Methyl-phenothiazine-10-ethanal | a-Methyl-phenothiazine-10-ethanal. Group: Biochemicals. Alternative Names: 1-(10H-Phenothiazin-10-yl)-2-propanone; Phenothiazin-10-yl-2-propanone. Grades: Highly Purified. CAS No. 15375-56-1. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. Molecular Formula: C15H13NOS. US Biological Life Sciences. | Worldwide |
| a-Methyl-phenothiazine-10-ethanol | a-Methyl-phenothiazine-10-ethanol. Group: Biochemicals. Alternative Names: a-Methyl-10H-phenothiazine-10-ethanol; 10- (b-Hydroxypropyl) phenothiazine. Grades: Highly Purified. CAS No. 32209-47-5. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C15H15NOS. US Biological Life Sciences. | Worldwide |
| Amethyst violet | Amethyst violet. Uses: Designed for use in research and industrial production. Additional or Alternative Names: AMETHYST VIOLET;CI 50225. Product Category: Heterocyclic Organic Compound. CAS No. 3562-38-7. Molecular formula: C26H31ClN4. Mole weight: 435. Purity: biological stain. Product ID: ACM3562387. Alfa Chemistry ISO 9001:2015 Certified. | |
| Ametoctradin | Ametoctradin ist eine chemische Verbindung aus der Gruppe der Triazol-Pyrimidylamine. Synonyms: 5-Ethyl-6-octyl[1,2,4]?triazolo[1,5-a]pyrimidin-7-amin. Grade: > 95%. CAS No. 865318-97-4. Molecular formula: C15H25N5. Mole weight: 275.4. | |
| Ametoctradin | Ametoctradin acts as a pesticide, and is used in fomulations of insecticides and fungicides. Group: Biochemicals. Grades: Highly Purified. CAS No. 865318-97-4. Pack Sizes: 25mg, 50mg. Molecular Formula: C15H25N5, Molecular Weight: 275.39. US Biological Life Sciences. | Worldwide |
| Ametoctradin | analytical standard. Group: Pesticides & metabolites standardspesticides & metabolitespesticides & metabolites. |  |
| Ametryn | Ametryn. Group: Biochemicals. Alternative Names: Ametryne; Cemerin; Doruplant; Evik; G 34162; Gesapax; N-Ethyl-N'-(1-methylethyl)-6-(methylthio)-1,3,5-triazine-2,4-diamine; NSC 163044; Primatol Z 80; 2-Ethylamino-4-isopropylamino-6-methylmercapto-s-triazine; 2-Ethylamino-4-isopropylamino-6-methylthio-1,3,5-triazine; 2-Ethylamino-4-isopropylamino-6-methylthio-s-triazine; 2-Ethylamino-4-methylthio-6-isopropylamino-1,3,5-triazine; 2-Methylmercapto-4-ethylamino-6-isopropylamino-s-triazine; 2-Methylthio-4-ethylamino-6-isopropylamino-s-triazine; 2-Methylthio-4-ethylamino-6-isopropylamino-sym-triazine; A 1093; Amephyt; Ametrex; 2-(Ethylamino)-4-(isopropylamino)-6-(methylthio)-s-triazine; N-Ethyl-N'-(1-methylethyl)-6-(methylthio)-1,3,5-triazine-2,4-diamine; N2-Ethyl-N4-(1-methylethyl)-6-(methylthio)-1,3,5-triazine-2,4-diamine. Grades: Highly Purified. CAS No. 834-12-8. Pack Sizes: 1g. Molecular Formula: C9H17N5S, Molecular Weight: 227.33. US Biological Life Sciences. | Worldwide |
| Ametryn | Ametryn, a member of the Triazine chemical family, is a herbicide which inhibits photosynthesis and other enzymatic processes. Ametryn is effective against annual broadleaf weeds and grasses [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 834-12-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 500 mg. Product ID: HY-B0866. |  |
| Amezinium methylsulfate | Amezinium metilsulfate has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition ofnoradrenaline and tyramine uptake. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Amezinium metilsulfate; Lu-1631. CAS No. 30578-37-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-A0275. | |
| Amezinium methylsulfate | Amezinium methylsulfate, a sympathomimetic drug used for the treatment of low blood pressure, increases the arterial blood pressure and heart rate of anaesthetized animals and of pithed rats by stimulating vascular alpha- and cardiac beta 1-adrenoceptors. Synonyms: Amezinium Metilsulfate; LU-1631; LU 1631; LU1631; Regulton; Risumic. 6-methoxy-1-phenylpyridazin-1-ium-4-amine methylsulfate; AMEZINIUM METHYL SULFATE; SUPRATONIN (GRUNENTHAL); RISUMIC (DAINIPPON); REGULTON (KNOLL); 4-amino-6-methoxy-1-phenyl-pyridaziniumethylsulfate; 4-amino-6-methoxy-1-phenylpyridazinium-methylsulfat; 4-amino-. CAS No. 30578-37-1. Molecular formula: C11H12N3O.CH3O4S. Mole weight: 313.33. | |
| Amezinium Methyl Sulfate | Amezinium Methyl Sulfate. Group: Biochemicals. Grades: Highly Purified. CAS No. 30578-37-1. Pack Sizes: 250mg, 5mg, 10g, 25g, 50g. Molecular Formula: C12H15N3O5S. US Biological Life Sciences. | Worldwide |
| AMF | AMF. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4'-(Aminomethyl)fluorescein. Product Category: Fluorescein Fluorophores. CAS No. 91539-64-9. Molecular formula: C21H16ClNO5. Mole weight: 397.81. Purity: 95%+. IUPACName: 7-(aminomethyl)-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one;hydrochloride. Product ID: ACM91539649-1. Alfa Chemistry ISO 9001:2015 Certified. | |
| Amfenac | Amfenac (2-Amino-3-benzoylbenzeneacetic acid) is a non-steroidal anti-inflammatory drug with acetic acid moiety. Synonyms: 2-Amino-3-benzoylphenylacetic acid; 2-Amino-3-benzoylbenzeneacetic acid; 2-(2-amino-3-benzoyl-phenyl)acetic acid. Grade: > 95%. CAS No. 51579-82-9. Molecular formula: C15H13NO3. Mole weight: 255.28. | |
| Amfenac-[d5] Sodium Salt | Amfenac-[d5] Sodium Salt is a labelled sodium compound of Amfenac. Amfenac is a COX inhibitor with IC50 of 0.25 and 0.15 μM for COX-1 and COX-2, respectively. Synonyms: 2-Amino-3-(benzoyl-d5)benzeneacetic Acid Sodium Salt. Grade: 95% by HPLC; 98% atom D. Molecular formula: C15H7D5NNaO3. Mole weight: 282.28. | |
| Amfenac Ethyl Ester | Amfenac Ethyl Ester. Uses: For analytical and research use. Group: Impurity standards. CAS No. 61941-57-9. IUPAC Name: ethyl 2-(2-amino-3-benzoylphenyl)acetate. Molecular formula: C17H17NO3. Mole weight: 283.32. Catalog: APS61941579. SMILES: CCOC(=O)Cc1cccc(C(=O)c2ccccc2)c1N. Format: Neat. Shipping: Room Temperature. | |
| Amfenac Lactam | A metabolite of Amfenac and Nepafenac. Synonyms: 7-Benzoyl-1,3-dihydro-2H-indol-2-one; 7-Benzoyl-2-indolinone. Grade: > 95%. CAS No. 51135-38-7. Molecular formula: C15H11NO2. Mole weight: 237.26. | |
| Amfenac Sodium Hydrate | Amfenac is an antibacterial agent. Group: Biochemicals. Alternative Names: 2-Amino-3-benzoylbenzeneacetic Acid Sodium Salt Hydrate; (2-Amino-3-benzoylphenyl)acetic Acid; NSC 309467. Grades: Highly Purified. CAS No. 61618-27-7. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Amfenac Sodium Hydrate | Amfenac Sodium Hydrate is a COX-2 inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 61618-27-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-17479A. | |
| Amfenac sodium salt hydrate | Amfenac sodium salt hydrate. Group: Biochemicals. Alternative Names: 2-Amino-3-benzoylbenzeneacetic acid sodium salt hydrate; (2-Amino-3-benzoylphenyl)acetic acid; NSC 309467. Grades: Highly Purified. CAS No. 61618-27-7. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C15H14NNaO4. US Biological Life Sciences. | Worldwide |
| Amflutizole | Amflutizole is a xanthine oxidase inhibitor. It inhibits free radical generation in the ischemic/reperfused rat cerebral cortex. Synonyms: 4-Amino-3-(3-(trifluoromethyl)phenyl)isothiazole-5-carboxylic acid. CAS No. 82114-19-0. Molecular formula: C11H7F3N2O2S. Mole weight: 288.25. | |
| AMG-009 | AMG-009 is an orally active, small molecule dual D prostanoid(DP) receptor and chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) antagonist. It was in preclinical development for the treatment of asthma and allergic rhinitis. It was developed by Amgen Inc. Uses: Amg-009 was in preclinical development for the treatment of asthma and allergic rhinitis. Synonyms: AMG-009; AMG 009; AMG009; 2-[4-[4-(Butylcarbamoyl)-2-[(2,4-dichlorophenyl)sulfonylamino]phenoxy]-3-methoxyphenyl]acetic acid; AMG009; Benzeneacetic acid, 4-(4-((butylamino)carbonyl)-2-(((2,4-dichlorophenyl)sulfonyl)amino)phenoxy)-3-methoxy-. Grade: >98 %. CAS No. 1027847-67-1. Molecular formula: C26H26Cl2N2O7S. Mole weight: 581.46. | |
| AMG-1 | AMG-1 is a potent inhibitor of human c-Met and RON with IC50 of 4 nM and 9 nM, respectively. Synonyms: c-Met/RON Dual Kinase Inhibitor; RON-IN-1. CAS No. 913376-84-8. Molecular formula: C31H29FN4O5. Mole weight: 556.58. | |
| AMG-126737 | AMG-126737 is a potent inhibitor of human lung mast cell tryptase (Ki = 90 nM), with greater than 10- to 200-fold selectivity versus other serine proteases. Synonyms: 3-[[4-[5-[4-[[(3-carbamimidoylphenyl)sulfonylamino]methyl]phenoxy]pentoxy]phenyl]methylsulfamoyl]benzenecarboximidamide; 1,5-bis-(4-((3-carbamimidoyl-benzenesulfonylamino)-methyl)-phenoxy)-pentane; AMG-126737; AMG 126737; AMG126737. Grade: >98%. CAS No. 224054-76-6. Molecular formula: C33H38N6O6S2. Mole weight: 678.82. | |
| AMG131 | AMG131 (INT131) is a potent non-thiazolidinedione (TZD) selective peroxisome proliferator-activated receptor ? modulator (SPPARM). AMG131 binds to PPAR? within the same binding pocket as the TZDs, but occupies a unique space in the pocket and contacts the receptor at distinct points from the TZDs. AMG131 is promising for research of type-2 diabetes mellitus[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: INT131. CAS No. 315224-26-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117103. | |
| AMG 18 hydrochloride | AMG-18 hydrochloride is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM. AMG-18 is a potent and selective IRE1α inhibitor with IC50 of 13 nM for recombinant and IC50 of 99 nM for cellular IRE1α. Synonyms: 2-Chloro-N-[6-methyl-5-[[3-[2-[(3S)-3-piperidinylamino]-4-pyrimidinyl]-2-pyridinyl]oxy]-1-naphthalenyl]benzenesulfonamide hydrochloride; Kira8 hydrochloride. Grade: ≥98% by HPLC. Molecular formula: C31H29ClN6O3S·HCl. Mole weight: 637.58. | |
| AMG-193 | AMG 193 is an orally active MTA-cooperative PRMT5 inhibitor with antitumor activity. AMG 193, when complexed with MTA, preferentially inhibits the growth of MTAP-deficient tumor cells by inhibiting PRMT5 ( IC 50 =0.107 μM), thereby protecting normal cells with wild-type MTAP [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2790567-82-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153390. | |
| AMG208 | AMG 208 is a selective small-molecule inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. C-Met encodes the hepatocyte growth factor receptor tyrosine kinase, plays an important role in epithelial cell proliferation and has been shown to be overexpressed in a variety of cancers. Synonyms: AMG-208; AMG208; AMG 208. Grade: 0.98. CAS No. 1002304-34-8. Molecular formula: C22H17N5O2. Mole weight: 383.411. | |
| AMG 21629 | AMG 21629 has been found to be an effective and selective TRPV1 antagonist, which could probably be useful in the treatment of pains associated with cancer and inflammatory diseases. Synonyms: AMG21629; AMG-21629; AMG 21629; 3-Amino-5-[[2-[(2-methoxyethyl)amino]-6-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2(1H)-quinoxalinone. Grade: ≥97% by HPLC. CAS No. 939040-79-6. Molecular formula: C22H19F3N6O3. Mole weight: 472.42. | |
| AMG232 | AMG232 is an extremely potent MDM2 inhibitor with remarkable pharmacokinetic properties and in vivo antitumor activity in the SJSA-1 osteosarcoma xenograft model (ED50 = 9.1 mg/kg). AMG232 is currently under clinical development. Synonyms: AMG-232; AMG 232. Grade: 0.98. CAS No. 1352066-68-2. Molecular formula: C28H35Cl2NO5S. Mole weight: 568.55. | |
| AMG2850 | AMG2850 is a potent, selective and orally bioavailable antagonist of transient receptor potential melastatin 8 (TRPM8). Synonyms: (8R)-8-[4-(Trifluoromethyl)phenyl]-N-[(2S)-1,1,1-trifluoro-2-propanyl]-5,8-dihydro-1,7-naphthyridine-7(6H)-carboxamide; 1,7-Naphthyridine-7(6H)-carboxamide, 5,8-dihydro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-8-[4-(trifluoromethyl)phenyl]-, (8R)-; (R)-8-(4-(trifluoromethyl)phenyl)-N-((S)-1,1,1-trifluoropropan-2-yl)-5,6-dihydro-1,7-naphthyridine-7(8H)-carboxamide. Grade: ≥98%. CAS No. 1470018-52-0. Molecular formula: C19H17F6N3O. Mole weight: 417.35. | |
| AMG319 | AMG319 is a potent and selective PI3Kδ kinase inhibitor with IC 50 of 18 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1608125-21-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12948. | |
| AMG319 | AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2. Synonyms: AMG319; AMG-319; AMG 319; ACP319; ACP-319; ACP 319. Grade: 98%. CAS No. 1608125-21-8. Molecular formula: C21H16FN7. Mole weight: 385.4. | |
| AMG 333 | AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM for hTRPM8 and IC50 of 20 nM for rTRPM8, which displays high selectivity over other TRP channels (IC50>20 uM, TRPV1/V3/V4/A1). AMG-333 was well-tolerated in 28 day rat and dog preclinical safety studies and advanced to Phase 1 human clinical trials. Synonyms: 6-[[[(S)-(3-Fluoro-2-pyridinyl)[3-fluoro-4-(trifluoromethoxy)phenyl]methyl]amino]carbonyl]-3-pyridinecarboxylic acid. Grade: ≥98% by HPLC. CAS No. 1416799-28-4. Molecular formula: C20H12F5N3O4. Mole weight: 453.33. | |
| AMG 333 | AMG 333 is an orally active and highly selective TRPM8 antagonist with an IC50 of 13 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1416799-28-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-112703. | |
| AMG-337 | AMG-337 is a potent, orally active, selective MET kinase inhibitor with IC 50 values of 1, 1, 4.7, 5, 21.5, 1077 and >4000 nM of WT MET, H1094R MET, M1250T MET, HGF-stimulated pMET (PC3 cells) MET, V1092I MET, Y1230H MET, and D1228H MET, respectively. AMG 337 inhibits the phosphorylation of MET and downstream effectors in MET-amplified cancer cell lines, resulting in an inhibition of MET-dependent cell proliferation and induction of apoptosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1173699-31-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-18696. | |
| AMG-337 | AMG 337 is an orally bioavailable inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. c-Met inhibitor AMG 337 selectively binds to c-Met, thereby disrupting c-Met signal transduction pathways. Synonyms: AMG337; AMG-337; AMG 337. Grade: 98%. CAS No. 1173699-31-4. Molecular formula: C23H22FN7O3. Mole weight: 463.47. | |
| AMG 369 | This active molecular is a S1P1/S1P5 agonist with limited activity at S1P3. AMG 369 has no activity at S1P2 and S1P4. AMG-369 is shown to reduce blood lymphocyte counts 24 hours postdose with dosed orally at 0.1 mg/kg. Till Jun 2016, no recent reports of development identified for preclinical development in Multiple-sclerosis in USA were published yet. Uses: Multiple sclerosis. Synonyms: AMG-369; AMG 369; AMG369; KB-74649; KB74649; KB 74649. 1-[[3-fluoro-4-[6-(1-phenylcyclopropyl)-[1,3]thiazolo[5,4-b]pyridin-2-yl]phenyl]methyl]azetidine-3-carboxylicacid; ZINC216149127; 1202073-26-4. Grade: 98%. CAS No. 1202073-26-4. Molecular formula: C26H22FN3O2S. Mole weight: 459.54. | |
| AMG-3969 | AMG-3969 is a potent and selective disruptor of glucokinase-glucokinase regulatory protein interaction (GK-GKRP). AMG-3969 can modulate the blood glucose levels in rodent models of diabetes. Synonyms: 2-[4-[(2S)-4-(6-aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol. Grade: 98% by HPLC. CAS No. 1361224-53-4. Molecular formula: C21H20F6N4O3S. Mole weight: 522.466. | |
| AMG410 | AMG410 is a non-covalent and selective pan-KRAS inhibitor with IC50 values of 1-4 nM for KRAS G12D, KRAS G12V, and KRAS G13D. AMG410 shows greater than 100-fold selectivity against both HRAS and NRAS. AMG410 is a dual GTP(on)- and GDP(off)-state inhibitor (Kd(GDP-state) of 1 nM; Kd(GTP-state) of 22 nM). AMG410 blocks KRAS signaling in a cycling state-independent manner and also blocks proliferation in wildtype KRAS-amplified tumor cells. AMG410 can be used for the study of colorectal, pancreatic, and lung cancers[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3040175-17-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-173632. | |
| AMG-458 | AMG 458 is a potent c-Met inhibitor with Ki of 1 nM ~ 2.0 nM. AMG-458 was found to significantly inhibit tumor growth in the NIH3T3/TPR-Met and U-87 MG xenograft models with no adverse effect on body weight. Synonyms: AMG458; AMG 458; 1-(2-Hydroxy-2-methylpropyl)-N-[5-[(7-methoxyquinolin-4-yl)oxy]pyridin-2-yl]-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide; 2,3-Dihydro-1-(2-hydroxy-2-methylpropyl)-N-[5-[(7-methoxy-4-quinolinyl)oxy]-2-pyridinyl]-5-methyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide. Grade: ≥98%. CAS No. 913376-83-7. Molecular formula: C30H29N5O5. Mole weight: 539.58. | |
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