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| Product | Description | |
|---|---|---|
| AMG-47a | AMG-47a is a potent inhibitor of Lck and T cell proliferation. It has anti-inflammatory activity (ED50 = 11 mg/kg) in the anti-CD3 induced production of IL-2 in mice. It displays subnanomolar inhibition against Lck, and low inhibition against other hard to inhibit kinases in several other in vitro assays. It effectively inhibits the JNK family of kinases including TYK2 at ~ 1.2 μM but well under 10 μM. It selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells. Uses: Amg-47a has anti-inflammatory activity. Synonyms: AMG-47a; AMG 47a; AMG47a; AMG-47; AMG 47; AMG47. 4-Methyl-3-[2-[[2-(4-morpholinyl)ethyl]amino]-6-quinazolinyl]-N-[3-(trifluoromethyl)phenyl]benzamide. Grade: 95%. CAS No. 882663-88-9. Molecular formula: C29H28F3N5O2. Mole weight: 535.56. |  |
| AMG-47a | AMG-47a is an orally active, ATP-competitive Lck inhibitor (IC50=0.2 nM). AMG-47a inhibits VEGF2, p38?, p38?, Jak3, MLR, and IL-2 with IC50 of 1 nM, 3 nM, 72 nM, 30 nM, and 21 nM, respectively. AMG-47a reduces T cell activation and the production of cytokines such as TGF-?, exerting anti-inflammatory and anti-fibrotic activities. AMG-47a can be used in the research of autoimmune diseases, pulmonary fibrosis, and KRAS mutation-associated cancers[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 882663-88-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-18303. |  |
| AMG 487 | AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 473719-41-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15319. | |
| AMG 487 | AMG 487 is a CXCR3 antagonist that inhibits cell migration and metastasis. Synonyms: AMG-487; AMG 487; AMG487. Benzeneacetamide, N-((1R)-1-(3-(4-ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl)ethyl)-N-(3-pyridinylmethyl)-4-(trifluoromethoxy)-; N-[(1R)-1-[3-(4-ethoxyphenyl)-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(pyridin-3-ylmethyl)-2-[4-(trifluorome. CAS No. 473719-41-4. Molecular formula: C32H28F3N5O4. Mole weight: 603.59. | |
| AMG 487 (S-enantiomer) | AMG 487 (S-enantiomer), the S-enantiomer of AMG 487, is an antagonist of the chemokine receptor CXCR3. Synonyms: N-{(1S)-1-[3-(4-Ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl]ethyl}-N-(3-pyridinylmethyl)-2-[4-(trifluoromethoxy)phenyl]acetamide; Benzeneacetamide, N-[(1S)-1-[3-(4-ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(3-pyridinylmethyl)-4-(trifluoromethoxy)-. Grade: ≥98%. CAS No. 473720-30-8. Molecular formula: C32H28F3N5O4. Mole weight: 603.59. | |
| AMG510 | AMG-510 is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity. At the 2019 World Conference on Lung Cancer (WCLC), Amgen declared the efficacy of AMG 510 for treating non-small cell lung cancer (NSCLC) with KRAS G12 C-mutated solid tumors. Amgen also announced prospective directions for AMG510 through academic scholars and reports the few limitations on official drug release as evidence for potential investors to consider the value of AMG 510. Synonyms: AMG 510; AMG-510; Sotorasib. Grade: ≥98%. CAS No. 2252403-56-6. Molecular formula: C30H30F2N6O3. Mole weight: 560.59. | |
| AMG-510 | AMG-510 Inhibitor. Uses: Scientific use. Product Category: T8684. CAS No. 2296729-00-3. |  |
| AMG510 racemate | AMG510 is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity. At the 2019 World Conference on Lung Cancer (WCLC), Amgen declared the efficacy of AMG510 for treating non-small cell lung cancer (NSCLC) with KRAS G12 C-mutated solid tumors. Amgen also announced prospective directions for AMG510 through academic scholars and reports the few limitations on official drug release as evidence for potential investors to consider the value of AMG510. Uses: Immune checkpoint inhibitors. Synonyms: AMG-510 racemate; AMG 510 racemate; Sotorasib racemate. CAS No. 2296729-00-3. Molecular formula: C30H30F2N6O3. Mole weight: 560.59. | |
| AMG 511 | AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks, with Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3K?, ?, ? and ?, respectively. AMG 511 significantly suppresses PI3K signaling that is indicated by p-Akt (Ser473) decrease. AMG 511 exhibits anti-tumor activity in mouse glioblastoma xenograft model[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1253573-53-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg. Product ID: HY-13440. | |
| AMG 517 | AMG 517 is a potent and selective vanilloid receptor-1 ( TRPV1 ) antagonist with an IC 50 of 0.5 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 659730-32-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10634. | |
| AMG-517 | AMG-517 is a potent and selective TRPV1 antagonist, antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM. Synonyms: AMG-517; AMG 517; AMG517; BD-0082; BD 0082; BD0082; BAY E 9736. Grade: >98%. CAS No. 659730-32-2. Molecular formula: C20H13F3N4O2S. Mole weight: 430.4. | |
| AMG 548 | AMG-548 is a selective p38α inhibitor with Ki value of 0.5nM. It displays >1000-fold selectivity against 36 other kinases, and it can inhibit whole blood LPS-stimulated TNFα. In Sep 2008, Preclinical for Rheumatoid arthritis in USA was discontinued. Uses: Inflammation; rheumatoid arthritis. Synonyms: AMG 548; AMG-548; AMG548; UNII-PGR0H531I4; 2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone. Grade: 98%. CAS No. 864249-60-5. Molecular formula: C29H27N5O. Mole weight: 461.56. | |
| AMG 548 | AMG 548. Group: Biochemicals. Grades: Purified. CAS No. 864249-60-5. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| AMG-548 | AMG-548, an orally active and selective p38α inhibitor ( K i=0.5 nM), shows slightly selective over p38β ( K i=36 nM) and >1000 fold selective against p38γ and p38&delta. AMG 548 is also extremely potent in the inhibition of whole blood LPS stimulated TNFα ( IC 50 =3 nM) [1]. AMG-548 inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 864249-60-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108642. | |
| AMG 548 (2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone) | Potent and selective inhibitor of p38alpha (Ki values are 0.5, 3.6, 2600 and 4100nm for p38a, p38beta, p38gamma and p38delta respectively). Displays >1000-fold selectivity against 36 other kinases; inhibits whole blood LPS-stimulated TNFalpha (IC50 = 3nm). Group: Biochemicals. Grades: Highly Purified. CAS No. 864249-60-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| AMG-548 dihydrochloride | AMG-548 dihydrochloride, an orally active and selective p38α inhibitor ( K i=0.5 nM), shows slightly selective over p38β ( K i=36 nM) and >1000 fold selective against p38γ and p38&delta. AMG-548 dihydrochloride is also extremely potent in the inhibition of whole blood LPS stimulated TNFα ( IC 50 =3 nM) [1]. AMG-548 dihydrochloride inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2518299-32-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108642B. | |
| AMG-548 dihydrochloride | AMG-548 dihydrochloride is an orally active and selective p38α inhibitor (Ki = 0.5 nM). It shows slightly selective over p38β (Ki = 36 nM) and >1000 fold selective against p38γ and p38δ. Grade: 99%. Molecular formula: C29H29Cl2N5O. Mole weight: 534.48. | |
| AMG-548 dihydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| AMG-628 | AMG-628 is a highly selective, ATP-competitive inhibitor of Raf kinases. It can inhibit activation of tyrosine protein kinases. AMG-628 can also inhibit growth, and induce cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-RafV600E mutation. Synonyms: AMG-628; AMG 628; AMG628; UNII-28J966TN3X; CHEMBL226574; N-(4-((6-(4-(1-(4-fluorophenyl)ethyl)-1-piperazinyl)-4-pyrimidinyl)oxy)-2-benzothiazolyl)-Acetamide. Grade: 98%. CAS No. 862269-73-6. Molecular formula: C25H25FN6O2S. Mole weight: 492.57. | |
| AMG-747 | AMG-747 is a GlyT-1 inhibitor. It has been under investigation to treat various CNS disorders that may be ameliorated by modulation of either inhibitory glycinergic or excitatory glutamatergic neurotransmission. It was used as an antipsychotic drug. It was developed by Amgen and was terminated in Cilnic phase 2. Uses: Amg-747 was used as an antipsychotic drug. Synonyms: 1-Piperazineacetic acid, 4-((R)-phenyl(3-(trifluoromethyl)phenyl)methyl)-; 2-[4-[(R)-phenyl-[3-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]acetic acid; Tilapertin; AMG747; AMG-747; AMG 747. Grade: >98 %. CAS No. 1000690-85-6. Molecular formula: C20H21F3N2O2. Mole weight: 378.39. | |
| AMG 837 | AMG 837 sodium salt is a potent GPR40 agonist with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. It displayed the expected two-fold increase in potency on GPR4 compared to the racemic compound and its activity crossed over to the rat and mouse forms of GPR40. It is a highly potent stimulator of insulin secretion in MIN6 cells with an EC50 comparable to that seen in the aequorin Ca2+-flux assay. It was a potent partial agonist in the calcium flux assay on the GPR40 receptor and potentiated glucose stimulated insulin secretion in vitro and in vivo. Synonyms: AMG-837, AMG837, AMG 837. Grade: >98%. CAS No. 865231-46-5. Molecular formula: C26H21F3O3. Mole weight: 438.44. | |
| AMG 837 calcium hydrate | AMG 837 calcium hydrate is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. Synonyms: AMG-837; AMG837; AMG 837. Grade: 0.98. CAS No. 1259389-38-2. Molecular formula: C52H42CaF6O7. Mole weight: 455.45. | |
| AMG 837 hemicalcium salt | The calcuim salt form of AMG 837, which has been found to be a GPR40 partial agonist and could probably be used as an antidiabetic agent. Synonyms: AMG 837 hemicalcium salt; AMG837 hemicalcium salt; AMG-837 hemicalcium salt; (βS)-β-1-Propyn-1-yl-4-[[4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]methoxy]benzenepropanoic acid hemicalcium salt. Grade: ≥98% by HPLC. CAS No. 1291087-14-3. Molecular formula: C26H20F3O3.½Ca. Mole weight: 457.47. | |
| AMG 837 sodium salt | AMG 837 sodium salt is a potent GPR40 agonist with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. It displayed the expected two-fold increase in potency on GPR4 compared to the racemic compound and its activity crossed over to the rat and mouse forms of GPR40. It is a highly potent stimulator of insulin secretion in MIN6 cells with an EC50 comparable to that seen in the aequorin Ca2+-flux assay. It was a potent partial agonist in the calcium flux assay on the GPR40 receptor and potentiated glucose stimulated insulin secretion in vitro and in vivo. Synonyms: AMG-837 sodium; AMG837 sodium; AMG 837 sodium; AMG-837 sodium salt. Grade: >98%. CAS No. 865231-45-4. Molecular formula: C26H20F3NaO3. Mole weight: 460.42. | |
| AMG8380 | AMG8380 is a potent and selective of the Voltage-Gated Sodium Channel Na V 1.7. Synonyms: AMG8379; (Rac)-AMG8380. CAS No. 1642112-32-0. Molecular formula: C25H16ClF2N3O5S. Mole weight: 543.93. | |
| AMG8562 | AMG8562 is a novel vanilloid receptor TRPV1 modulator. Synonyms: AMG-8562; AMG8562; AMG 8562; (E)-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-4-yl]-3-[2-piperidin-1-yl-4-(trifluoromethyl)phenyl]prop-2-enamide; AMG-8562; 2-Propenamide, N-((2R)-2,3-dihydro-2-hydroxy-1H-inden-4-yl)-3-(2-(1-piperidinyl)-4-(trifluoromethyl)phenyl)-, (2E)-. Grade: >98 %. CAS No. 1041478-78-7. Molecular formula: C24H25F3N2O2. Mole weight: 430.47. | |
| AMG-8718 | This active molecular is a potent BACE1 inhibitor that is a potential target for the treatment of Alzheimer's disease. AMG-8718 produced significantly reductions of CSF and brain Aβ levels in animal models. It also exhibited reduced potential for QTc elongation in a cardiovascular safety model. BACE1 inhibition has direct efficacy in the Alzheimer's disease pathology but it does not affect viability largely. Uses: The treatment of alzheimer's disease. Synonyms: AMG8718; AMG 8718; AMG-8718. (4S)-7'-(2-fluoropyridin-3-yl)-3'-[2-(3-methyloxetan-3-yl)ethynyl]spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-b]pyridine]-2-amine. Grade: 98%. CAS No. 1215868-94-2. Molecular formula: C25H19FN4O3. Mole weight: 442.45. | |
| AMG 900 | AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor with IC 50 of 5 nM, 4 nM and 1 nM for Aurora A , B and C , respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 945595-80-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13253. | |
| AMG-900 | AMG 900 is a small-molecule inhibitor of Aurora kinases A, B and C with potential antineoplastic activity. Aurora kinase inhibitor AMG 900 selectively binds to and inhibits the activities of Aurora kinases A, B and C, which may result in inhibition of cellular division and proliferation in tumor cells that overexpress these kinases. Synonyms: AMG900; AMG-900; AMG 900. Grade: 0.98. CAS No. 945595-80-2. Molecular formula: C28H21N7OS. Mole weight: 503.57764. | |
| AMG 925 | AMG-925 is a potent, selective, and bioavailable FLT3/cyclin-dependent kinase 4 (CDK4) dual kinase inhibitor. AMG 925 inhibited AML xenograft tumor growth by 96% to 99% without significant body weight loss. The antitumor activity of AMG 925 correlated with the inhibition of STAT5 and RB phosphorylation, the pharmacodynamic markers for inhibition of FLT3 and CDK4, respectively. In addition, AMG 925 was also found to inhibit FLT3 mutants (e.g., D835Y) that are resistant to the current FLT3 inhibitors (e.g., AC220 and sorafenib). AMG 925, which combines inhibition of two kinases essential for proliferation and survival of FLT3-mutated AML cells, may improve and prolong clinical responses. Synonyms: AMG925; AMG-925; AMG 925; FLX925; FLX-925; FLX 925. Grade: >98%. CAS No. 1401033-86-0. Molecular formula: C26H29N7O2. Mole weight: 471.55. | |
| AMG 925 HCl | AMG 925 HCl is a potent, selective and orally available dual inhibitor of FLT3/CDK4 with IC50s of 2±1 nM and 3±1 nM, respectively. Synonyms: 2-Hydroxy-1-[2-{[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino}-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]ethanone hydrochloride (1:1); Ethanone, 1-[7,8-dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxy-, hydrochloride (1:1). Grade: ≥98%. CAS No. 1401034-19-2. Molecular formula: C26H30ClN7O2. Mole weight: 508.02. | |
| AMG-978 | AMG-978 is an inhibitor of beta-secretase 1 (BACE1) (IC50 = 27 nM) which is in the preclinical study for the treatment of Alzheimer's disease. Uses: The potential treatment of alzheimer's disease. Synonyms: AMG 978; AMG978. | |
| AMG9810 | AMG9810 is a selective and competitive vanilloid receptor 1 ( TRPV1 ) antagonist with IC 50 values of 24.5 and 85.6 nM for human and rat TRPV1, repectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 545395-94-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-101736. | |
| AMG 9810 | AMG 9810. Group: Biochemicals. Grades: Purified. CAS No. 545395-94-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| AMG 9810 | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. | |
| AMG-9810 | AMG-9810 is potent, non-vanilloid and selective TRPV1 receptor antagonist with IC50 value of 17 nM. It inhibits capsaicin-, proton-, heat- and endogenous ligand-induced activation of human and rat recombinant TRPV1 receptors. It displays antihyperalgesic properties in a rat model of inflammatory pain. It was developed by Amgen. Uses: Amg-9810 displays antihyperalgesic properties. Synonyms: AMG-9810; AMG9810; AMG 9810. (2E)-N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-propanamide; 2-PropenaMide, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-diMethylethyl)phenyl]-, (2E)-; (E)-3-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)prop-2-enami. Grade: 98%. CAS No. 545395-94-6. Molecular formula: C21H23NO3. Mole weight: 337.41. | |
| Amgen-23 | Amgen-23 is a potent sphingosine kinases (SPHK) inhibitor. Grade: 98% by HPLC. CAS No. 1448706-15-7. Molecular formula: C23H25Cl2N3O2S. Mole weight: 478.4. | |
| AMG PERK 44 | AMG PERK 44 is a potent and selective PERK inhibitor with IC50 of 6 nM, which exhibits 160-fold selectivity over B-Raf, GCN2 and a panel of 387 other kinases. Synonyms: 4-[2-Amino-4-methyl-3-(2-methyl-6-quinolinyl)benzoyl]-1,2-dihydro-1-methyl-2,5-diphenyl-3H-pyrazol-3-one hydrochloride. Grade: ≥98%. CAS No. 1883548-84-2. Molecular formula: C34H28N4O2·HCl. Mole weight: 561.07. | |
| AMG PERK 44 | AMG PERK 44 is an orally active and highly selective PERK inhibitor with an IC50 of 6 nM. AMG PERK 44 has 1000-fold and 160-fold selectivity over GCN2 (IC50=7300 nM) and B-Raf (IC50 >1000 nM), respectively. AMG PERK 44 induces autophagy[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1883548-84-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12661A. | |
| AMI-1 | Potent, cell permeable and specific protein arginine N-methyltransferase 1 (PRMT1) inhibitor (IC50 = 8.8uM). Does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site. Blocks peptide substrate binding. HIV-1 RT polymerase inhibitor (IC50 = 5.0uM). Group: Biochemicals. Alternative Names: Arginine N-methyltransferase inhibitor-1. Grades: Highly Purified. CAS No. 160994-87-6, 134-47-4. Pack Sizes: 5mg, 25mg. Molecular Formula: C21H12N2O9S2Na4. US Biological Life Sciences. | Worldwide |
| AMI-1 | AMI-1 is a cell-permeable inhibitor which inhibits protein arginine N-methyltransferase (PRMT) activity with IC50 of 8.81 μM for PRMT1 and IC50 of 3.04 μM for Hmt1p in vitro. MI-1 does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site and exhibits minimal effects on both SET (Sub39H1, Suv39H2, SET7) and non-SET (DOT1) lysine N-methyltransferases. Furthermore, AMI-1 prevents in vivo arginine methylation of cellular proteins and can modulate nuclear receptor-regulated transcription from estrogen and androgen response elements, thus operating as a brake on certain hormone actions. Synonyms: 7,7'-(Carbonyldiimino)bis[4-hydroxy-2-naphthalenesulfonic acid] disodium salt; 5,5'-Dihydroxy-2,2'-dinaphthylcarbamide-7,7'-disulfonic acid disodium salt; 6,6'-Ureylenebis(1-naphthol-3-sulfonic acid) disodium salt; 7,7'-Ureylenebis(4-hydroxy-2-naphthalenesulfonic acid) disodium salt; Carbonyl J disodium salt; I Acid Urea disodium salt; N,N'-Bis(5-hydroxy-7-sulfo-2-naphthyl)urea disodium salt; N,N'-Bis(7-sulfo-5-hydroxy-2-naphthyl)urea disodium salt; N,N'-Bis[1-hydroxy-3-sulfonaphthyl(6)]urea disodium salt; N,N'-Bis[1-oxy-3-sulfonaphthyl(6)]urea disodium salt; AMI-1 sodium salt; AMI 1; AMI1; J Acid Urea disodium salt. Grade: ≥98%. CAS No. 20324-87-2. Molecular formula: C21H14N2Na2O9S2. Mole weight: 548.45. | |
| AMI-193 | AMI-193 has been found to be a selective 5-HT antagonist and could be also used as a starting reagent in some pharmaceutical synthesis. Synonyms: Spiramide; R 5808; R-5808; R5808; 8-[3-(4-Fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]-decanone. Grade: ≥99% by HPLC. CAS No. 510-74-7. Molecular formula: C22H26FN3O2. Mole weight: 383.46. | |
| AMI-193 | AMI-193. Group: Biochemicals. Grades: Purified. CAS No. 510-74-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| AMI-1 (Arginine N-methyltransferase Inhibitor-1) (Sodium Salt) | PRMT1,3,4 & 6 Inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| AMI-1 sodium salt hydrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Amibegron hydrochloride | Amibegron hydrochloride is a selective β3-adrenoceptor agonist, with an EC 50 of 3.5 nM for β-adrenoceptor in rat colon; Amibegron hydrochloride has anxiolytic and antidepressant activity. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SR 58611A. CAS No. 121524-09-2. Pack Sizes: 10 mM * 1 mL; 5 mg. Product ID: HY-103207. | |
| Amicarbalide | Amicarbalide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Amicarbalide. Product Category: Heterocyclic Organic Compound. CAS No. 3459-96-9. Molecular formula: C15H16N6O. Mole weight: 296.332. Purity: 0.96. IUPACName: 1,3-bis(3-carbamimidoylphenyl)urea. Canonical SMILES: C1=CC(=CC(=C1)NC(=O)NC2=CC=CC(=C2)C(=N)N)C(=N)N. Density: 1.4g/cm³. ECNumber: 222-402-7. Product ID: ACM3459969. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Amicarbazone | The phenotypic responses of sensitive plants exposed to amicarbazone include chlorosis, stunted growth, tissue necrosis, and death. Its efficacy as both a foliar- and root-applied herbicide suggests that absorption and translocation of this compound is very rapid. As a result, its efficacy is susceptible to the most common form of resistance to PSII inhibitors. Nonetheless, amicarbazone has a good selectivity profile and is a more potent herbicide than atrazine, which enables its use at lower rates than those of traditional photosynthetic inhibitors. Synonyms: BAY314666; BAY-MKH 3586; BAY 314666; BAY-MKH3586. Grade: >98%. CAS No. 129909-90-6. Molecular formula: C10H19N5O2. Mole weight: 241.29. | |
| Amicarbazone | Amicarbazone (BAY-MKH3586; BAY314666) becomes an effective inhibitor of photosynthetic electron transport by binding to the Qb site of photosystem II (PSII); it is a herbicide with broad-spectrum weed control. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY314666; BAY-MKH 3586. CAS No. 129909-90-6. Pack Sizes: 100 mg. Product ID: HY-17513. | |
| Amicarbazone Impurity 1 | An impurity of Amicarbazone. Synonyms: N-(1,1-Dimethylethyl)-2,5-dihydro-3-(1-methylethyl)-5-oxo-1H-1,2,4-triazole-1-carboxamide. Grade: > 95%. CAS No. 889062-05-9. Molecular formula: C10H18N4O2. Mole weight: 226.28. | |
| Amicarbazone Impurity 2 | An impurity of Amicarbazone. Synonyms: N-(1,1-Dimethylethyl)-2,5-dihydro-3-(1-hydroxy-1-methylethyl)-5-oxo-1H-1,2,4-triazole-1-carboxamide. Grade: > 95%. CAS No. 889062-06-0. Molecular formula: C10H18N4O3. Mole weight: 242.28. | |
| Amicenomycin A | It is produced by the strain of Streptomyces sp. MJ384-46F6. It has anti-gram-positive bacterial activity. Molecular formula: C43H56O16. Mole weight: 828.89. | |
| Amicenomycin B | It is produced by the strain of Streptomyces sp. MJ384-46F6. It has weak anti-gram-positive bacterial activity. Molecular formula: C43H56O16. Mole weight: 828.89. | |
| Amicetin | It is produced by the strain of Streptomuces vinaceusdrappus. It is mainly resistant to gram-positive bacteria and Mycobacterium. The MIC for S.aureus 209P and Mycobacterium tuberculosis H37 Rv were 2.0 and 0.5 μg/mL, respectively, and for Mycoplasma pneumoniae was 12.5 μg/mL. Molecular formula: C29H42N6O9. Mole weight: 618.68. | |
| Amicetin A | It is produced by the strain of Streptomuces vinaceusdrappus. The antibacterial activity is lower than that of Amicetin. Synonyms: AMICETIN; Amicetin-A; (4S)-N-{(4S)-1-[(2R,5S,6R)-5-{[4,6-dideoxy-4-(dimethylamino)-alpha-D-glucopyranosyl]oxy}-6-methyloxan-2-yl]-2-oxo-1,2,3,4-tetrahydropyrimidin-4-yl}-4-[(2-methyl-D-seryl)amino]cyclohexa-1,5-diene-1-carboxamide. CAS No. 17650-86-1. Molecular formula: C29H42N6O9. Mole weight: 618.68. | |
| Amicetin B | It is produced by the strain of Streptomuces sp. R-285. The antibacterial activity was lower than that of Amicetin. Synonyms: Plicacetin; Benzamide, 4-amino-N-(1-(5-((4,6-dideoxy-4-(dimethylamino)-alpha-D-glucopyranosyl)oxy)tetrahydro-6-methyl-2H-pyran-2-yl)-1,2-dihydro-2-oxo-4-pyrimidinyl)-, (2R-(2-alpha,5-beta,6-alpha))-; DTXSID70962868; 4-amino-N-[1-[5-[5-(dimethylamino)-3,4-dihydroxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]-2-oxopyrimidin-4-yl]benzamide. CAS No. 43043-15-8. Molecular formula: C25H35N5O7. Mole weight: 517.57. | |
| Amicetin C | It is produced by the strain of Streptomuces vinaceusdrappus. The antibacterial activity was lower than that of Amicetin. CAS No. 102646-94-6. Molecular formula: C56H94N10O19S. Mole weight: 1243.48. | |
| Amiclenomycin | It is produced by the strain of Streptomyces lavendulae subsp. amiclenomycini. It can inhibit the activity of Mycobacterium, and also has effect on kanamycin resistant Mycobacterium nucleum. Biotin and Desthiobiocin can offset their activities. Synonyms: Amyclenomycin; 2-Amino-4-(4-amino-2,5-cyclohexadienyl)butyric acid. CAS No. 53696-70-1. Molecular formula: C10H16N2O2. Mole weight: 196.25. | |
| Amicoumacin A | It is produced by the strain of Bacillus pumilus BN-103. It has anti-gram-positive bacterial activity and can inhibit foot paw edema (inflammation) caused by carrageenan in rats, which is similar to Phenylbutazone, and has a stronger effect on preventing gastric ulcer in rats than Sulpiride. Synonyms: Antibiotic BN 103; (3S)-3alpha-[(S)-1-[[(2S,3S,4S)-1,6-Dioxo-2,3-dihydroxy-4,6-diaminohexyl]amino]-3-methylbutyl]-8-hydroxy-3,4-dihydro-1H-2-benzopyran-1-one. CAS No. 56592-30-4. Molecular formula: C20H29N3O7. Mole weight: 423.46. | |
| Amicoumacin B | It is produced by the strain of Bacillus pumilus BN-103. It is an antibiotic that resists gram-positive bacteria. Synonyms: Hexonic acid, 3-amino-2,3,6-trideoxy-6-[[1-(3,4-dihydro-8-hydroxy-1-oxo-1H-2-benzopyran-3-yl)-3-methylbutyl]amino]-6-oxo-. CAS No. 82768-33-0. Molecular formula: C20H28N2O8. Mole weight: 424.44. | |
| Amicoumacin C | It is produced by the strain of Bacillus pumilus BN-103. It is an antibiotic that resists gram-positive bacteria. Synonyms: D-ribo-Hexar-6-amic acid, 3-amino-2,3-dideoxy-N-[1-(3,4-dihydro-8-hydroxy-1-oxo-1H-2-benzopyran-3-yl)-3-methylbutyl]-, γ-lactone, [S-(R*,R*)]-; AI 77Ba; D-ribo-Hexonic acid, 3-amino-2,?3,?6-trideoxy-6-[[(1S)?-1-[(3S)?-3,?4-dihydro-8-hydroxy-1-oxo-1H-2-benzopyran-3-yl]?-3-methylbutyl]?amino]?-6-oxo-, γ-lactone. CAS No. 77682-31-6. Molecular formula: C20H26N2O7. Mole weight: 406.43. | |
| Amidantel | Amidantel is a bio-active chemical compound. It is used as anthelmintics. Uses: Amidantel is used as anthelmintics. Synonyms: Amidantel free base; Amidantelum; 4'-((1-(Dimethylamino)ethylidene)amino)-2-methoxyacetanilide; Bay-d-8815. Grade: 98%. CAS No. 49745-00-8. Molecular formula: C13H19N3O2. Mole weight: 249.31. | |
| Amidantel hydrochloride | Amidantel is a potent anthelminthic agent. Uses: Anthelminthic. Synonyms: BAY-d 8815; N-(4-((1-(Dimethylamino)-aethyliden)amino)phenyl)-2-methoxyacetamid-hydrochlorid; 49745-00-8(free base). Grade: 98%. CAS No. 69884-15-7. Molecular formula: C13H19N3O2.ClH. Mole weight: 285.77. | |
| amidase | This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is acylamide amidohydrolase. Other names in common use include acylamidase, acylase, amidohydrolase, deaminase, fatty acylamidase, and N-acetylaminohydrolase. This enzyme participates in 6 metabolic pathways: urea cycle and metabolism of amino groups, phenylalanine metabolism, tryptophan metabolism, cyanoamino acid metabolism, benzoate degradation via coa ligation, and styrene degradation. Group: Enzymes. Synonyms: acylamidase; acylase (misleading); amidohydrolase (ambiguous); deaminase (ambiguous); fatty acylamidase; N-acetylaminohydrolase (ambiguous). Enzyme Commission Number: EC 3.5.1.4. CAS No. 9012-56-0. Amidase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4428; amidase; EC 3.5.1.4; 9012-56-0; acylamidase; acylase (misleading); amidohydrolase (ambiguous); deaminase (ambiguous); fatty acylamidase; N-acetylaminohydrolase (ambiguous). Cat No: EXWM-4428. |  |
| Amidase | Amidases, a member of nitrilase superfamily, catalyzes the hydrolysis of an amide, leading to the formation of carboxylic acid and ammonia. Amidases contain a conserved stretch of approximately 130 amino acids known as the AS sequence, and play a role in important metabolic processes [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9012-56-0. Pack Sizes: 250 U; 1 KU. Product ID: HY-P2736. | |
| Amidase from Pseudomonas aeruginosa, Recombinant | The amidase from Pseudomonas aeruginosa catalyzes the hydrolysis of a small range of short aliphatic amides. Each amidase monomer is formed by a globular four-layer αββα sandwich domain with an additional 81-residue long C-terminal segment. This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. Applications: The importance of these hydrolases in biotechnology is growing rapidly, because their potential applications span through chemical and pharmaceutical industries as well as in bioremediation. immobilized amidase can be used efficiently for production of ac...onyms: acylamidase; acylase (misleading); amidohydrolase (ambiguous); deaminase (ambiguous); fatty acylamidase; N-acetylaminohydrolase (ambiguous); amidase; EC 3.5.1.4; acylamide amidohydrolase. Enzyme Commission Number: EC 3.5.1.4. CAS No. 9012-56-0. Amidase. Activity: >200 units/mg protein (biuret). Storage: Store at -20°C. Form: Solution in 50% glycerol containing 7 mM 2-mercaptoethanol and phosphate buffer salt. Source: E. coli. Species: Pseudomonas aeruginosa. acylamidase; acylase (misleading); amidohydrolase (ambiguous); deaminase (ambiguous); fatty acylamidase; N-acetylaminohydrolase (ambiguous); amidase; EC 3.5.1.4; acylamide amidohydrolase. Cat No: NATE-0809. | |
| Amidases | synthesis of chiral carboxylic acids and amides. Group: Enzymes. Synonyms: Amidases; AMD. Form: 1. Enzyme Powder: 18 items*50mg / item, or other quantity2. Screening Kit: 18 items*1mg / item. Amidases; AMD; Screening Kit; library of enzyme; enzyme library. Cat No: ENLC-003. | |
| Amidated Pectin | Amidated pectin is a modified form of pectin, a natural plant-based polysaccharide found in fruits such as apples and citrus fruits. Amidated pectin is created by chemically modifying pectin with ammonia or other alkaline agents to introduce amide groups to the pectin molecule. Uses: Antidiarrheals. Synonyms: Pectin amide; Amid AF 005; INS 440; Pectin Amid AF 025; Pectin Amid AU-L 027/09; Pectin Amid CU 025; Pectin D. CAS No. 56645-02-4. | |
| Amidepsin E | It is produced by the strain of Humicola sp. FO-5969. It has a weak inhibition of DGAT activity, and the IC50 of DGAT in rat liver microparticles is 124 ?ol/L, respectively. It has no toxicity to Raji cells and no antibacterial activity. Molecular formula: C30H31NO11. Mole weight: 581.57. | |
| Amidepsine A | It is produced by the strain of Humicola sp. FO-2942. It inhibits DGAT activity, and the IC50 of rat liver microsomes DGAT is 10.1 X 10-6mol/L. It also inhibits triacylglycerol formation in intact Raji cells. Synonyms: Benzoic acid,2,4-dimethoxy-6-methyl-,4-[[4-[[(1-carboxyethyl)amino]carbonyl]-3-hydroxy-5-methylphenoxy]carbonyl]-3-hydroxy-5-methylphenylester (9ci); FO-2942A. Grade: ≥95%. CAS No. 169181-28-6. Molecular formula: C29H29NO11. Mole weight: 567.54. | |
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