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| Product | Description | |
|---|---|---|
| BAY 11-7082 | BAY 11-7082 completely and specifically abrogates NF-κB DNA binding, downregulating the NF-κB-inducible cytokine IL-6 and inducing apoptosis. Synonyms: BAY 11-7821; BAY 11-7082; BAY11-7082; BAY-11-7082; BAY 117082; BAY117082; BAY-117082. Grades: >98%. CAS No. 19542-67-7. Molecular formula: C10H9NO2S. Mole weight: 207.25. |  |
| BAY 11-7082 | BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 ( IC 50 =0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY 11-7821. CAS No. 19542-67-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13453. |  |
| BAY 11-7082 ((E)-3-(4-Methylphenylsulfonyl)-2-propenenenitrile) | Potential anti-inflammatory agent. Selectively and irreversibly inhibits NF-kB activation by blocking TNF-a-induced phosphorylation of IkB-a without affecting constitutive IkB-a phosphorylation. Inhibits the TNF-a-induced surface expression of adhesion molecules ICAM-1, VCAM-1, and E-selectin in human endothelial cells with IC50 values of 5-10uM. Group: Biochemicals. Grades: Highly Purified. CAS No. 195462-67-7. Pack Sizes: 10mg, 50ug. US Biological Life Sciences. |  Worldwide |
| Bay 11-7085 | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. |  |
| Bay 11-7085 | BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM. Synonyms: Bay 11-7085; Bay-11-7085; Bay11-7085; Bay 117085; Bay-117085; Bay117085. Grades: >98%. CAS No. 196309-76-9. Molecular formula: C13H15NO2S. Mole weight: 249.33. | |
| Bay 11-7085 | Bay 11-7085. Group: Biochemicals. Grades: Purified. CAS No. 196309-76-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| BAY 11-7085 | BAY 11-7085 (BAY 11-7083) is an inhibitor of NF-?B activation and phosphorylation of I?B?; it stabilizes I?B? with an IC50 of 10 ?M[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY 11-7083. CAS No. 196309-76-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10257. | |
| Bay 11-7821 | Bay 11-7821. Group: Biochemicals. Grades: Purified. CAS No. 19542-67-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| BAY 1214784 | BAY 1214784 is a potent, selective, and orally active antagonist of the human gonadotropin-releasing hormone receptor ( hGnRH-R ). BAY 1214784 is a spiroindoline derivative compound. BAY 1214784 effectively lowers plasma luteinizing hormone levels by up to 49%, at the same time being associated with low pharmacokinetic variability and good tolerability. BAY 1214784 has the potential for the research of uterine fibroids [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1631164-25-4. Pack Sizes: 5 mg. Product ID: HY-144863. | |
| BAY1217389 | BAY 1217389 is a potent, and selective inhibitor of the monopolar spindle 1 (MPS1) kinase with an IC50 value less than 10 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1554458-53-5. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12859. | |
| BAY-1217389 | BAY-1217389, an imidazopyridazin derivative, has been found to be a TTK protein inhibitor that could probably be effective as an antineoplastic agent and also be a potentialcell death stimulant. It is still under Phase I trail for solid tumor. Synonyms: BAY1217389; BAY-1217389; BAY 1217389; N-cyclopropyl-4-(6-(2,3-difluoro-4-methoxyphenoxy)-8-((3,3,3-trifluoropropyl)amino)imidazo[1,2-b]pyridazin-3-yl)-2-methylbenzamide. Grades: 98%. CAS No. 1554458-53-5. Molecular formula: C27H24F5N5O3. Mole weight: 561.51. | |
| BAY-1251152 | BAY-1251152 is a potent and selective CDK9 inhibitor with anti-tumor activity. Synonyms: BAY 1251152; BAY1251152; (+)-BAY-1251152. Grades: ≥98% by HPLC. CAS No. 1610358-56-9. Molecular formula: C19H18F2N4O2S. Mole weight: 404.4. | |
| BAY 1436032 | BAY-1436032 is a highly selective, potent and orally available inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1). It is a double-digit nanomolar and selective pan-inhibitor of the enzymatic activity of various IDH1-R132X mutants in vitro and displays potent inhibition of 2-HG release (nanomolar range) in patient derived and engineered cell lines expressing different IDH1 mutants. BAY 1436032 strongly reduces 2-HG (2-hydroxyglutarate) levels in cells carrying IDH1-R132H, -R132C, -R132G, -R132S and -R132L mutations. BAY 1436032 showed a favourable selectivity profile against wtIDH1/2 and a large panel of off-targets in vitro. Synonyms: 3-(2-[[4-(Trifluoromethoxy)phenyl]amino]-1-[(1R,5R)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)propanoic Acid; BAY-1436032. Grades: ≥98%. CAS No. 1803274-65-8. Molecular formula: C26H30F3N3O3. Mole weight: 489.53. | |
| BAY-1436032 | BAY-1436032 is a potent, selective and orally available inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1). BAY 1436032 is a double-digit nanomolar and selective pan-inhibitor of the enzymatic activity of various IDH1-R132X mutants in vitro and displayed potent inhibition of 2-HG release (nanomolar range) in patient derived and engineered cell lines expressing different IDH1 mutants. In line with the proposed mode of action, a concentration-dependent lowering of 2-HG was observed in vitro accompanied by differentiation and maturation of mIDH1 tumor cells. Furthermore, BAY 1436032 showed a favourable selectivity profile against wtIDH1/2 and a large panel of off-targets in vitro. Uses: Designed for use in research and industrial production. Additional or Alternative Names: BAY-1436032; BAY 1436032; BAY1436032. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1803274-65-8. Molecular formula: C26H30F3N3O3. Mole weight: 489.54. Purity: >98%. IUPACName: 3-(2-((4-(trifluoromethoxy)phenyl)amino)-1-((1R,5R)-3,3,5-trimethylcyclohexyl)-1H-benzo[d]imidazol-5-yl)propanoic acid. Canonical SMILES: O=C(O)CCC1=CC=C2N([C@H]3CC(C)(C)C[C@@H](C)C3)C(NC4=CC=C(OC(F)(F)F)C=C4)=NC2=C1. Product ID: ACM1803274658. Alfa Chemistry ISO 9001:2015 Certified. |  |
| BAY-179 | BAY-179 is a potent, selective, and species cross-reactive OXPHOS complex I inhibitor. Uses: Designed for use in research and industrial production. Additional or Alternative Names: BAY-179; BAY 179; BAY179. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2764880-87-5. Molecular formula: C23H21N5OS. Mole weight: 415.52. Purity: >98%. IUPACName: 2-(1-((1H-Imidazo[4,5-b]pyridin-2-yl)methyl)piperidin-4-yl)-4-(benzofuran-2-yl)thiazole. Canonical SMILES: C1(C2CCN(CC3=NC4=NC=CC=C4N3)CC2)=NC(C5=CC6=CC=CC=C6O5)=CS1. Product ID: ACM2764880875. Alfa Chemistry ISO 9001:2015 Certified. Categories: BAY 1896953. | |
| BAY-179 | BAY-179 is a potent, selective, and species cross-reactive complex I inhibitor. BAY-179 shows IC50 values of 79 nM, 38 nM, 27 nM, and 47 nM for human, mouse, rat, and dog complex I, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2764880-87-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145707. | |
| BAY-1797 | BAY-1797 is a potent, orally active, and selective P2X4 antagonist, with an IC50 of 211 nM against human P2X4. BAY-1797 displays no or very weak activity on the other P2X ion channels. BAY-1797 shows anti-nociceptive and anti-inflammatory effects[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2055602-83-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130605. | |
| BAY-1816032 | BAY-1816032 is a potent and oral available BUB1 (budding uninhibited by benzimidazoles 1) kinase inhibitor with an IC50 of 7 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1891087-61-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103020. | |
| BAY-1895344 | BAY-1895344 is a selective ATR (ataxia-telangiectasia and Rad3 related protein) inhibitor that inhibits proliferation of a broad spectrum of human tumor cell lines (median IC50 = 78 nM). BAY-1895344 is developed for the treatment of patients with advanced solid tumors and lymphomas, and it is undergoing a phase I clinical trial of safety and tolerability for cancer patients. Uses: A selective atr (ataxia-telangiectasia and rad3 related protein) inhibitor used for the treatment of advanced solid tumors and lymphomas. Synonyms: BAY-1895344; BAY 1895344; BAY1895344; (R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine. Grades: ≥98 %. CAS No. 1876467-74-1. Molecular formula: C20H21N7O. Mole weight: 375.181. | |
| BAY-1895344 hydrochloride | BAY-1895344 is a potent, orally available and highly selective ATR inhibitor (IC50= 7 nM), which potently inhibits proliferation of a broad spectrum of human tumor cell lines (median IC50 = 78 nM). In cellular mechanistic assays BAY 1895344 potently inhibited hydroxyurea-induced H2AX phosphorylation (IC50 = 36 nM). Synonyms: Elimusertib hydrochloride; BAY 1895344 hydrochloride; BAY1895344 hydrochloride; 2-[(3R)-3-Methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-3-yl)-1,7-naphthyridine hydrochloride; 2-[(3R)-3-methylmorpholin-4-yl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine hydrochloride; Bay 1895344; 1,7-Naphthyridine, 2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-3-yl)-, hydrochloride (1:1). Grades: ≥95%. Molecular formula: C20H22ClN7O. Mole weight: 411.89. | |
| BAY 19-8004 | BAY 19-8004 is a selective inhibitor of phosphodiesterase-4 (PDE4) used for the treatment of COPD. Uses: The treatment of copd. Synonyms: Lirimilast; SMR004703312; [3-(carbamoylamino)-2-(2,4-dichlorobenzoyl)-1-benzofuran-6-yl] methanesulfonate. Grades: 98%. CAS No. 329306-27-6. Molecular formula: C17H12Cl2N2O6S. Mole weight: 443.26. | |
| BAY-204 | BAY-204 is an inhibitor of Casein kinase 1 alpha and delta (CSNK1? and ?) useful for the research of proliferative disorders. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BRD3727. CAS No. 2468784-57-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-145940. | |
| BAY-218 | BAY-218, which is known as BAY-2335218, is a potent and selective small-molecule AhR inhibitor with an IC50 of 39.9 nM in human cell line. It is a new modality to counteract tumor immunosuppression. Synonyms: BAY 218; BAY218; BAY-2335218; BAY 2335218; BAY2335218; (S)-6-(4-chlorophenyl)-2-(3-fluorophenyl)-N-(1-hydroxypropan-2-yl)-3-oxo-2,3-dihydropyridazine-4-carboxamide; AHR antagonist 1. Grades: ≥98%. CAS No. 2162982-11-6. Molecular formula: C20H17ClFN3O3. Mole weight: 401.82. | |
| BAY-218 | BAY-218 (AHR antagonist 1) is an aryl hydrocarbon receptor (AHR) antagonist. BAY-218 has AHR inhibitory activity with an IC 50 of 39.9 nM in in U87 glioblastoma cells. BAY-218 can be used for the research of cancer or conditions with dysregulated immune responses [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AHR antagonist 1. CAS No. 2162982-11-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111449. | |
| BAY-2402234 | BAY-2402234 is a selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of myeloid malignancies. Uses: Scientific research. Group: Signaling pathways. CAS No. 2225819-06-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112645. | |
| BAY-2402234 | BAY-2402234 is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of myeloid malignancies. BAY 2402234 is a selective low-nanomolar inhibitor of human DHODH enzymatic activity. In vitro, it potently inhibits proliferation of AML cell lines in the sub-nanomolar to low-nanomolar range. BAY 2402234 induces differentiation of AML cell lines also in a sub-nanomolar to low-nanomolar range, demonstrating the anticipated mode of action in cellular mechanistic assays. In vivo, BAY 2402234 exhibits strong in vivo anti-tumor efficacy in monotherapy in several subcutaneous and disseminated AML xenografts as well as AML patient-derived xenograft (PDX) models. Uses: Designed for use in research and industrial production. Additional or Alternative Names: BAY-2402234; BAY 2402234; BAY2402234; Orludodstat; Orludodstatum. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2225819-06-5. Molecular formula: C21H18ClF5N4O4. Mole weight: 520.84. Purity: >98%. IUPACName: (S)-N-(2-chloro-6-fluorophenyl)-4-(4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-5-fluoro-2-((1,1,1-trifluoropropan-2-yl)oxy)benzamide. Canonical SMILES: FC1=C(NC(C2=CC(F)=C(N3N=C(CO)N(CC)C3=O)C=C2O[C@@H](C)C(F)(F)F)=O)C(Cl)=CC=C1. Product ID: ACM2225819065. Alfa Chemistry ISO 9001:2015 Certified. | |
| BAY 2416964 | BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 192, has an IC 50 of 341 nM. BAY 2416964 has the potential for solid tumors treatment [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2242464-44-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135829. | |
| BAY 2416964 | BAY 2416964 is a potent, orally active, aromatic hydrocarbon receptor (AHR) antagonist, which has the potential to treat solid tumors. Synonyms: BAY2416964; (S)-6-(4-Chlorophenyl)-N-(1-Hydroxypropan-2-Yl)-2-(1-Methyl-1H-Pyrazol-4-Yl)-3-Oxo-2,3-Dihydropyridazine-4-Carboxamide. Grades: ≥98% by HPLC. CAS No. 2242464-44-2. Molecular formula: C18H18ClN5O3. Mole weight: 387.8. | |
| BAY-27-9955 | BAY-27-9955 is a specific glucagon receptor antagonist. Synonyms: 1-[2-(4-fluorophenyl)-4,6-di(propan-2-yl)-3-propylphenyl]ethanol; BAY-27-9955; BAY-27-9955; BAY-27-9955; BAY-279955; BAY-279955; BAY-279955; (+)-3,5-diisopropyl-2-(1-hydroxyethyl)-6-propyl-4'-fluoro-1,1'-biphenyl. Grades: >98%. CAS No. 202855-56-9. Molecular formula: C23H31FO. Mole weight: 342.49. | |
| BAY-293 | BAY-293 is a potent and cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction with IC50 of 21 nM. It shows antiproliferative activity against wild-type KRAS cell lines with IC50 of 1 uM and cell lines with KRASG12C mutation with IC50 of 3 uM by preventing formation of the KRAS-SOS1 complex. It is a valuable chemical probe for future investigations. Synonyms: BAY 293; BAY293; (R)-6,7-dimethoxy-2-methyl-N-(1-(4-(2-((methylamino)methyl)phenyl)thiophen-2-yl)ethyl)quinazolin-4-amine. Grades: ≥98%. CAS No. 2244904-70-7. Molecular formula: C25H28N4O2S. Mole weight: 448.58. | |
| BAY-293 | BAY-293, a valuable chemical probe, blocks RAS activation via disruption of the KRAS-SOS1 interaction with an IC50 of 21 nM. BAY-293 is a potent inhibitor of Son of Sevenless 1 (SOS1). SOS1 is the guanine nucleotide exchange factor (GEF) and activator of RAS[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2244904-70-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114398. | |
| BAY 2965501 | BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGK?) inhibitor. BAY 2965501 induces pERK activation. BAY 2965501 can be used for the research of cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2732902-08-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153343. | |
| BAY 299 | BAY 299 is a potent and selective inhibitor of BRD1 and TAF1 (IC50 = 6-67 and 8-13 nM, respectively) with selectivity over other bromodomains (>30-fold over other members of the BRPF family; BRD9 and ATAD2; >300-fold over BRD4). BAY 299 suppresses binding of BRD1 and TAF1 to histone H4 (IC50 = 575 nM and 0.9 μM, respectively) and histone H3.3 (IC50 = 825 nM and 1.4 μM, respectively). Synonyms: BAY-299; BAY 299; BAY299. 6-(3-Hydroxypropyl)-2-(1,3,6-trimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione. Grades: ≥98% by HPLC. CAS No. 2080306-23-4. Molecular formula: C25H23N3O4. Mole weight: 429.47. | |
| BAY-299 | BAY-299 is a very potent, dual inhibitor with IC50s of 67 nM for BRPF2 bromodomains (BD), 8 nM for TAF1 BD2, and 106 nM for TAF1L BD2. Uses: Scientific research. Group: Signaling pathways. CAS No. 2080306-23-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107424. | |
| BAY-299 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BAY32-5915 | BAY32-5915 is a potent IKK? inhibitor with an IC50 value of 60 nM. BAY32-5915 has not affect Doxorubicin (HY-15142A)-induced NF-?B activation[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1571-30-8. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-W067427. | |
| BAY-364 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Bay 36-7620 | BAY 36-7620 elective mGlu1 receptor non-competitive antagonist (IC50 = 0.16 μM) with inverse agonist activity. Synonyms: (3aS,6aS)-5-methylidene-3a-(naphthalen-2-ylmethyl)-1,4,6,6a-tetrahydrocyclopenta[c]furan-3-one; BAY-36-7620; BAY 36-7620; BAY367620; UNII-0P934RSF8B. Grades: >98 %. CAS No. 232605-26-4. Molecular formula: C19H18O2. Mole weight: 278.349. | |
| BAY-3827 | BAY-3827 is a potent and selective AMPK inhibitor with IC50 values of 1.4 nM at low (10 ?M ATP concentration) and 15 nM at high (2 mM ATP concentration). BAY-3827 shows over 500-fold selectivity for most of the 331 kinases. BAY-3827 prevents phosphorylation of acetyl-CoA carboxylase 1 and shows strongest anti-proliferative activity in androgen-dependent prostate cancer cell lines[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2377576-35-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-112083. | |
| BAY-386 | BAY-386 is a novel PAR1 receptor inhibitor that suppresses activation of thrombin and platelet. It is orally active, and has the potential to treat coagulation disorders such as arterial thrombosis. Uses: The potential treatment of coagulation disorders. Synonyms: BAY 386; BAY386. CAS No. 1256941-06-6. Molecular formula: C22H25F3N4O5S. Mole weight: 514.52. | |
| BAY 41-2272 | BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator. Synonyms: BAY 41-2272; BAY-41-2272; BAY41-2272; BAY412272; BAY-412272; BAY 412272. Grades: 98%. CAS No. 256376-24-6. Molecular formula: C20H17FN6. Mole weight: 360.39. | |
| BAY 41-2272 | ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BAY 41-2272 | BAY 41-2272. Group: Biochemicals. Alternative Names: 5-Cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyrimidinamine. Grades: Highly Purified. CAS No. 256376-24-6. Pack Sizes: 10mg. Molecular Formula: C20H17FN6, Molecular Weight: 360.39. US Biological Life Sciences. | Worldwide |
| BAY 41-2272 | BAY 41-2272 is an orally active and soluble guanylate cyclases ( sGC ) activator, which increases sGC activity by 400-fold in synergy with NO. BAY 41-2272 potently unloaded the heart, increased cardiac output, thus can be used for cardiovascular diseases research [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 256376-24-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12376. | |
| BAY 41-4109 | BAY 41-4109 is a novel drug inhibiting hepatitis B virus capsid formation and replication. Synonyms: BAY-41-4109; BAY41-4109; BAY 41-4109; BAY-414109; BAY414109; BAY 414109. methyl (4R)-4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate. Grades: >98%. CAS No. 298708-81-3. Molecular formula: C18H13ClF3N3O2. Mole weight: 395.766. | |
| Bay 41-4109 less active enantiomer | Bay 41-4109 less active enantiomer exhibits less activity than Bay 41-4109 that is a novel class of drugs and inhibits hepatitis B virus (HBV) capsid formation and replication. Synonyms: methyl (4R)-4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate; BAY 41-4109; methyl-(R)-4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridinyl)-6-methyl-1,4-dihydro-pyrimidine-5-carboxylate. Grades: ≥98% (HPLC). CAS No. 476617-51-3. Molecular formula: C18H13ClF3N3O2. Mole weight: 395.76. | |
| BAY41-4109 racemic | BAY41-4109 racemic, a mixture of R-isomer of BAY41-4109 and S-isomer of BAY41-4109, is an antiviral compound that inhibits HBV replication by destabilizing capsid assembly, with an IC50 of 53 nM. Synonyms: Methyl 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate; BAY-41-4109; BAY41-4109; BAY 41-4109; BAY-414109; BAY414109; BAY 414109. Grades: ≥98.0%. CAS No. 298708-79-9. Molecular formula: C18H13ClF3N3O2. Mole weight: 395.76. | |
| BAY-41-8543 | BAY-41-8543, with antihypertensive, is a heme-dependent stimulator of NO-independent guanylyl cyclase (sGC). In vivo, BAY 41-8543 decreases blood pressure dose-dependently, prolongs bleeding time, and reduces thrombosis. In vitro, BAY 41-8543 induces relaxation of aorta, saphenous arteries, coronary arteries and veins. Synonyms: -[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]-5-morpholin-4-ylpyrimidine-4,6-diamine; BAY-41-8543; BAY418543; BAY41-8543; UNII-323T2C09SG. Grades: 95%. CAS No. 256498-66-5. Molecular formula: C21H21FN8O. Mole weight: 420.44. | |
| BAY-545 | BAY-545 is a potent and selective A2B adenosine receptor antagonist with IC50 of 59 nM. Synonyms: GTPL11224; EX-A2960; BAY 545; BAY545. Grades: 98%. CAS No. 1699717-32-2. Molecular formula: C18H22F3N3O4S. Mole weight: 433.4. | |
| BAY-549 | BAY-549 (Azaindole 1) is an orally active and ATP-competitive ROCK inhibitor with IC 50 s of 0.6 and 1.1?nM for human ROCK-1 and ROCK-2 , respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ROCK-IN-2; Azaindole 1; TC-S 7001. CAS No. 867017-68-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10319. | |
| BAY-5516 | BAY-5516 is a inverse-agonist o PPAR G, with the IC 50 value of 6.1±3.6 nM that has anti-tumor effect [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2891706-79-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-160160. | |
| Bay 55-9837 | Bay 55-9837. Group: Biochemicals. Grades: Purified. CAS No. 463930-25-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Bay 55-9837 | Bay 55-9837 is a selective VPAC2 receptor agonist (EC50 = 0.4, 100 and >1000 nM for VPAC2, VPAC1 and PAC1, respectively in a cAMP accumulation assay; IC50=60, 8700 and >10000 nM for VPAC2, VPAC1 and PAC1, respectively in a competition binding assay). It promotes glucose-dependent insulin secretion in isolated human pancreatic islets and inhibits HIV-1 viral replication. CAS No. 463930-25-8. Molecular formula: C167H270N52O46. Mole weight: 3742.29. | |
| BAY 56-3722 | BAY 56-3722 is a water-soluble camptothecin derivative conjugated to a carbohydrate moiety exhibiting antineoplastic activity. BAY 56-3722 stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. The peptide carbohydrate moiety of this agent stabilizes the lactone form of camptothecin in blood. Synonyms: BAY-563722; BAY56 3722; BAY 38-3441; BAY 38 344; (S)-4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl ((4-(((2R,3S,4R,5R,6S)-3,5-dihydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)phenyl)carbamothioyl)-L-histidyl-L-valinate. CAS No. 215604-75-4. Molecular formula: C45H50ClN7O11S. Mole weight: 895.98. | |
| BAY 56-3722 hydrochloride | BAY 56-3722, a water-soluble camptothecin derivative, is a DNA-Intercalating drug that stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. Synonyms: BAY 56-3722; BAY56-3722; BAY-56-3722; N-[4- (6-Deoxy-3-O-methyl-beta-L-galactopyranosyloxy) phenylaminothiocarbonyl]-L-histidyl-L-valine 4(S)-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl ester hydrochloride; N-[4-(3-O-Methyl-beta-L-fucopyranosyloxy)p; Afeletecan hydrochloride; BAY 38-3441; L-Valine, N- ( ( (4- ( (6-deoxy-3-O-methyl-beta-L-galactopyranosyl) oxy) phenyl) amino) thioxomethyl) -L-histidyl-, (4S)-4-ethyl-3,4,12,14-tetrahydro-3,14-dioxo-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-4-yl ester, hydrochloride (1:1); 215604-75-4 (BAY 56-3722 free base); 215604-74-3 (BAY 56-3722 HCl salt; 215604-66-3 (diastereomeric mixture). Grades: >98%. CAS No. 215604-74-3. Molecular formula: C45H49N7O11S.HCl. Mole weight: 932.447. | |
| BAY-57-1293 | BAY 57-1293 represents a new class of potent inhibitors of herpes simplex virus (HSV) that target the virus helicase primase complex. Potent helicase-primase inhibitor (HPI) effective against herpes simplex virus (HSV) infections with IC50 value of 20 nM for inhibition of the replication of both HSV-1 and HSV-2 in Vero cells, and ED50 value of 0.5 mg/kg for both HSV-1 and HSV-2 in the murine lethal challenge model of disseminated herpes. Uses: For research used only. Synonyms: Pritelivir; BAY-57-1293; BAY 57-1293; BAY-57 1293; BAY 57 1293; BAY571293; AIC316; AIC 316; AIC-316. Grades: 98%. CAS No. 348086-71-5. Molecular formula: C18H18N4O3S2. Mole weight: 402.49. | |
| BAY 58-2667 hydrochloride | BAY 58-2667, also known as Cinaciguat, is a potent nitric oxide (NO)-independent soluble guanylyl cyclase (sGC) activator (EC50 = 6.4 nM). It exhibits antihypertensive effects in vivo and is used in the treatment of acute decompensated heart failure (ADHF). Synonyms: 5-Fluoro-2-methoxy-[1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]-1H-indole-3-methylcarboxylate Sulfamate; Cinaciguat HCl; BAY 582667 HCl; BAY-582667 HCl; BAY582667 HCl; BAY 58-2667 HCl; BAY-58-2667 HCl; BAY58-2667 HCl; Cinaciguat HCl. Grades: ≥98% by HPLC. CAS No. 646995-35-9. Molecular formula: C36H39NO5.HCl. Mole weight: 602.16. | |
| BAY 58-2667 hydrochloride | Nitric oxide (NO)- and heme-independent soluble guanylyl cyclase activator. Shows potent cardiovascular effects. Improves cardiopulmonary hemodynamics in patients with acute decompensated heart failure. Exhibits potent vasodilator and antiplatelet activity. Anti-aggregating agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 1240669-95-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| BAY-588 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BAY-588 | BAY-588 is a glucose transporter inhibitor and derivative of BAY-876. BAY-876 is a potent, highly selective, cell-permeable inhibitor of glucose transporter GLUT1. It selectively inhibits glucose transporter 4 (Glut4), Glut1, and Glut3 over Glut2 with IC50 values of 0.5, 1.18, 5.47, and >10 μM, respectively, in CHO cells expressing human recombinant transporters. Synonyms: BAY 588; BAY588; N4-[1-[[4-(1,1-Dimethylethyl)phenyl]methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-quinolinedicarboxamide. Grades: ≥98%. CAS No. 1799759-24-2. Molecular formula: C27H25F4N5O2. Mole weight: 527.5. | |
| BAY 59-3074 | Bay 59-3074 is a novel, selective CB1/CB2 receptor partial agonist(Ki values are 48.3 and 45.5 nM at human CB1 and CB2 receptors respectively). Uses: Novel cb1/cb2 receptor partial agonist. Synonyms: BAY-59-3074; BAY 59-3074; BAY59-30743-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl 4,4,4-trifluoro-1-butanesulfonic acid ester. Grades: ≥98%. CAS No. 406205-74-1. Molecular formula: C18H13F6NO4S. Mole weight: 453.358. | |
| BAY-598 | BAY-598 is a potent, peptide-competitive chemical probe for SET and MYND domain-containing protein 2 (SMYD2), IC50 values of 27 nM and 58 nM for biochemical and cellular activity, respectively. BAY 598 exhibits 100-fold selectivity for SMYD2 over other histone methyltransferases and non-epigenetic enzymes. Synonyms: (S, E) -N- (1- (N'-cyano-N- (3- (difluoromethoxy) phenyl) carbamimidoyl) -3- (3, 4-dichlorophenyl) -4, 5-dihydro-1H-pyrazol-4-yl) -N-ethyl-2-hydroxyacetamide; BAY-598; BAY 598; BAY598. CAS No. 1906919-67-2. Molecular formula: C22H20Cl2F2N6O3. Mole weight: 525.33. | |
| BAY-598 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BAY-598 R-isomer | BAY-598 R-isomer is the R-isomer of BAY589 which is a potent, peptide-competitive chemical probe for SET and MYND domain-containing protein 2 (SMYD2), IC50 values of 27 nM and 58 nM for biochemical and cellular activity, respectively. BAY 598 exhibits 100-fold selectivity for SMYD2 over other histone methyltransferases and non-epigenetic enzymes. Synonyms: (R, E) -N- (1- (N'-cyano-N- (3- (difluoromethoxy) phenyl) carbamimidoyl) -3- (3, 4-dichlorophenyl) -4, 5-dihydro-1H-pyrazol-4-yl) -N-ethyl-2-hydroxyacetamide; BAY-598 R-isomer; BAY 598 R-isomer; BAY598 R-isomer. CAS No. 1906920-28-2. Molecular formula: C22H20Cl2F2N6O3. Mole weight: 525.33. | |
| BAY 59-9435 | BAY 59-9435 is a potent and selective inhibitor of Hormone Sensitive Lipase (HSL), with an IC50 of 0.023 ?M. Uses: Scientific research. Group: Signaling pathways. CAS No. 654059-21-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-102056. | |
| BAY 60-2770 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BAY 60-2770 | BAY 60-2770 is a potent, selective, and orally active soluble guanylyl cyclase (sGC) activator. BAY 60-2770 increases the activity of sGC in a nitric oxide-independent manner. BAY 60-2770 shows antifibrotic effect[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1027642-43-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113926. | |
| BAY-6035 | BAY-6035 is an inhibitor of SET and MYND domain-containing protein 3 (SMYD3) with IC50 of 70 nMm, which exhibits >100-fold selectivity for SMYD3 over other histone methyltransferases. BAY-6035 inhibits methylation of MEKK2 peptide in a cell-free assay and in cell. Synonyms: (2S)-1-(3-azabicyclo[3.1.0]hex-3-ylcarbonyl)-N-(2-cyclopropylethyl)-2,3,4,5-tetrahydro-2-methyl-4-oxo-1H-1,5-benzodiazepine-7-carboxamide. Grades: ≥95%. CAS No. 2247890-13-5. Molecular formula: C22H28N4O3. Mole weight: 396.48. | |
| BAY-6035 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BAY-6035 | BAY-6035 is a potent, selective and substrate-competitive inhibitor of SMYD3. BAY-6035 inhibits methylation of MEKK2 peptide with an IC 50 of 88 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2247890-13-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112080. | |
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