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| Product | Description | |
|---|---|---|
| BI-2536 | BI-2563 is a small molecule compound with potential antineoplastic activities. BI 2536 binds to and inhibits Polo-like kinase 1 (Plk1), resulting in mitotic arrest, disruption of cytokinesis, and apoptosis in susceptible tumor cell populations. Plk1, a serine/threonine-protein kinase, is a key regulator of multiple processes fundamental to mitosis and cell division. Synonyms: BI2536; BI 2536. Grades: 0.98. CAS No. 755038-02-9. Molecular formula: C28H39N7O3. Mole weight: 521.65. |  |
| BI-2545 | BI-2545 is a potent autotaxin (ATX) inhibitor that significantly reduces LPA, with IC 50 s of 2.2 nM and 3.4 nM for human ATX and rat ATX, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2162961-71-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124772. |  |
| BI-2545 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| BI-2852 | BI-2852 is a KRAS inhibitor. It blocks the interaction of GEF, GAP and effectors with KRAS, thereby inhibiting downstream signal transduction and producing anti-proliferative effects in KRAS mutant cells. Synonyms: BI-2852; 2375482-51-0; CHEMBL4750445; (3~{S})-3-[2-[[[1-[(1-methylimidazol-4-yl)methyl]indol-6-yl]methylamino]methyl]-1~{H}-indol-3-yl]-5-oxidanyl-2,3-dihydroisoindol-1-one; (3S)-5-hydroxy-3-[2-[[[1-[(1-methylimidazol-4-yl)methyl]indol-6-yl]methylamino]methyl]-1H-indol-3-yl]-2,3-dihydroisoindol-1-one; F0K; SCHEMBL24414712; BCP31539; EX-A4793; BDBM50549225; s8959; AKOS040732592; BI2852; BI 2852; MS-29593; HY-126247; CS-0100975; A934943; (S)-5-Hydroxy-3-(2-((((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methyl)amino)methyl)-1H-indol-3-yl)isoindolin-1-one; (S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methylamino)methyl)-1H-indol-3-yl)isoindolin-1-one. Grades: ≥98% by HPLC. CAS No. 2375482-51-0. Molecular formula: C31H28N6O2. Mole weight: 516.6. | |
| BI-2852 | BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based agent design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) and binds ten-fold more strongly to active KRASG12D versus KRASwt (740 nM vs 7.5 ?M). BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells. Uses: Scientific research. Group: Signaling pathways. CAS No. 2375482-51-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126247. | |
| BI-2865 | BI-2865 is a none-covalent pan-KRAS Inhibitor. BI-2865 binds to WT, G12C, G12D, G12V and G13D mutant KRAS with KDs of 6.9, 4.5, 32, 26, 4.3 nM respectively. BI-2865 inhibits the proliferation of G12C, G12D or G12V mutant KRAS expressing BaF3 cells (mean IC50: roughly 140 nM)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2937327-93-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153724. | |
| Bi2Te3 Crystal | Bi2Te3 Crystal. Uses: Designed for use in research and industrial production. Additional or Alternative Names: bismuthsesquitelluride;bismuthtelluride(bi2te3);bismuthtelluride,undoped;bismuthtritelluride;tellurobismuthite;tellururedebismuth;BISMUTH TELLURIDE;BISMUTH (III) TELLURIDE. Product Category: Graphene-like Materials Series. CAS No. 1304-82-1. Molecular formula: Bi2Te3. Mole weight: 800.76. Purity: 0.99995. Product ID: ACM1304821. Alfa Chemistry ISO 9001:2015 Certified. |  |
| BI-3406 | BI-3406 (compound I-6) is an orally active, highly potent and selective inhibitor of the interaction between KRAS and Son of Sevenless 1 (SOS1) with an IC50 of 6 nM. BI-3406 potently reduces the formation of GTP-loaded KRAS, and inhibits MAPK pathway signaling. BI-3406 has anticancer activity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2230836-55-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-125817. | |
| BI-3406 | BI-3406 is a potent and selective inhibitor of the interaction between KRAS and Son of Sevenless 1 (SOS1). SOS1 is the guanine nucleotide exchange factor (GEF) and activator of RAS, and mutants of RAS are major oncogenes and occur in many human cancers. Inhibition of SOS1 in a mutant KRAS cell line can suppress tumor growth. Synonyms: BI 3406; BI3406. CAS No. 2230836-55-0. Molecular formula: C23H25F3N4O3. Mole weight: 462.5. | |
| BI-3406 | BI-3406 is Potent & Selective SOS1:KRAS Inhibitor (IC50=5 nM), which Opens a New Approach for Treating KRAS-Driven Tumours. BI 3406 selectively binds to SOS1 and blocks the interaction with KRAS, irrespective of the KRAS mutation. BI 3406 causes RAS GTP and pERK reduction and inhibits cell growth of KRAS mutated cell lines, carrying most of the typical KRAS mutations (i.e. G12D, G12V, G13D and others). BI 3406, when administered orally to tumour bearing mice, causes a dose dependent tumour static effect that can be converted into regressions when combined with MEK1 inhibition. Uses: Designed for use in research and industrial production. Additional or Alternative Names: BI-3406; BI 3406; BI3406. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2230836-55-0. Molecular formula: C23H25F3N4O3. Mole weight: 462.47. Purity: >98%. IUPACName: N-((R)-1-(3-amino-5-(trifluoromethyl)phenyl)ethyl)-7-methoxy-2-methyl-6-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-4-amine. Canonical SMILES: C[C@H](C1=CC(N)=CC(C(F)(F)F)=C1)NC2=C3C(C=C(OC)C(O[C@H]4CCOC4)=C3)=NC(C)=N2. Product ID: ACM2230836550. Alfa Chemistry ISO 9001:2015 Certified. | |
| BI-3802 | BI-3802 is a highly potent BCL6 degrader that inhibits the Bric-à-brac (BTB) domain of BCL6 with an IC50 of ≤3 nM. It induces BCL6 polymerization and degradation via E3 ligase SIAH1, showing antitumor activity. Grades: ≥98% by HPLC. CAS No. 2166387-65-9. Molecular formula: C24H29ClN6O3. Mole weight: 484.98. | |
| BI-3802 | BI-3802 is a highly potent BCL6 degrader and inhibits the Bric-à-brac (BTB) domain of BCL6 with an IC50 of ?3 nM. BI-3802 induces the polymerization of BCL6 and promotes BCL6 degration depended on E3 ligase SIAH1. BI-3802 has antitumor activity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2166387-65-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108705. | |
| BI-3812 | BI-3812 is potent and efficacious BCL6 inhibitor. It inhibits the BTB domain of BCL6 with an IC50 of ≤3 nM. The high potency and good permeability properties of BI-3812 make this molecule a very good cellular probe compound for testing hypotheses around BCL6 biology. The transcription factor BCL6 is a known driver of oncogenesis in lymphoid malignancies, including diffuse large B cell lymphoma (DLBCL). Synonyms: BI-3812; 2166387-64-8; CHEMBL4755229; 1-(5-chloro-4-((8-methoxy-1-methyl-3-(2-(methylamino)-2-oxoethoxy)-2-oxo-1,2-dihydroquinolin-6-yl)amino)pyrimidin-2-yl)-N,N-dimethylpiperidine-4-carboxamide; SCHEMBL20284237; AMY16876; BCP31903; EX-A2841; BDBM50546197; s8735; AKOS040741329; SB40386; BI 3812; BI3812; AC-31571; MS-30157; HY-111381; CS-0040299; A935150; EN300-22885148; Z3417458909; 1-[5-chloro-4-({8-methoxy-1-methyl-3-[(methylcarbamoyl)methoxy]-2-oxo-1,2-dihydroquinolin-6-yl}amino)pyrimidin-2-yl]-N,N-dimethylpiperidine-4-carboxamide; 1-[5-Chloro-4-({8-methoxy-1-methyl-3-[2-(methylamino)-2-oxoethoxy]-2-oxo-1,2-dihydro-6-quinolinyl}amino)-2-pyrimidinyl]-N,N-dimethyl-4-piperidinecarboxamide; 1-[5-chloro-4-[[8-methoxy-1-methyl-3-[2-(methylamino)-2-oxoethoxy]-2-oxoquinolin-6-yl]amino]pyrimidin-2-yl]-N,N-dimethylpiperidine-4-carboxamide. Grades: ≥98%. CAS No. 2166387-64-8. Molecular formula: C26H32ClN7O5. Mole weight: 558.03. | |
| BI-4394 | BI-4394 (MMP13-IN-3) is a potent, selective, and orally active MMP-13 inhibitor ( IC 50=1 nM [1] ) for the potential treatment of osteoarthritis [2]. BI-4394 is >1000 selective over other MMPs [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MMP13-IN-3. CAS No. 1222173-37-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124029. | |
| BI-4464 | BI-4464 is a highly selective, ATP competitive PTK2/FAK protein kinase inhibitor with an IC50 value of 17 nM. BI-4464 can be used as a PTK2 ligand for constructing proteolysis targeting chimeras (PROTAC). Uses: Scientific research. Group: Signaling pathways. CAS No. 1227948-02-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124625. | |
| BI-44847 | BI-44847 is a synthetic bio-active chemical had been in phase II clinical trials for the treatment of type 2 diabetes. Uses: Sodium-glucose transporter 2 inhibitors. Synonyms: BI-44847; BI 44847; BI44847; UNII-43WJ33399D; beta-D-Glucopyranoside,4-((2-fluoro-4-methoxyphenyl)methyl)- 5-methyl-1-(1-methylethyl)-1H-pyrazol-3-yl. Grades: ≥98%. CAS No. 421592-30-5. Molecular formula: C21H29FN2O7. Mole weight: 440.46. | |
| BI-4834 | BI-4834 is a potent and selective Polo-like kinase 1 (PLK1) inhibitor. Synonyms: BI4834; BI 4834. Grades: >98%. CAS No. 876371-13-0. Molecular formula: C21H42N4O3S3. Mole weight: 593.76. | |
| BI-4916 | BI-4916 is a proagent of BI-4924. BI-4924 is a NADH/NAD+-competitive PHGDH inhibitor. BI-4916 inhibits cancer cell migration. BI-4916 can be used for cancer, inflammation and infection study[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2244451-48-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126253. | |
| BI 6015 | BI 6015 is a hepatocyte nuclear factor 4α (HNF4α) antagonist that suppresses expression of known HNF4α target genes. BI 6015 produces cytotoxicity in a range of tumor cell lines, including human hepatocellular carcinoma. Synonyms: BI6015; BI 6015; BI-6015. 2-Methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole. Grades: ≥98% by HPLC. CAS No. 93987-29-2. Molecular formula: C15H13N3O4S. Mole weight: 331.35. | |
| BI 6015 | BI 6015. Group: Biochemicals. Grades: Purified. CAS No. 93987-29-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| BI-6015 | BI-6015 is a hepatocyte nuclear factor 4? (HNF4?) antagonist that can inhibit the expression of known HNF4? target genes. BI6015 represses insulin promoter activity through HNF4? antagonism. BI-6015 can be used for the research of cancer and diabetes[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 93987-29-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108469. | |
| BI605906 | BI605906 is a novel pharmacological inhibitors of the IKK family. It inhibits IKKβ with an IC50 value of 380 nM when assayed at 0.1 mM ATP in vitro. It also inhibits TNFα-dependent IκB degradation and expression of pro-inflammatory mediators IL-6, IL-1b, and CXCL1/2. It not only prevents the phosphorylation of physiological substrates, but also prevents the phosphorylation of the serine residues in IKKβ that trigger its activation. Uses: Bi605906 not only prevents the phosphorylation of physiological substrates, but also prevents the phosphorylation of the serine residues in ikkβ that trigger its activation. Synonyms: BI605906; BI-605906; BI 605906;3-AMino-4-(1,1-difluoropropyl)-6-(4-Methylsulfonylpiperidin-1-yl)thieno[2,3-b]pyridine-2-carboxaMide. Grades: >98 %. CAS No. 960293-88-3. Molecular formula: C17H22F2N4O3S2. Mole weight: 432.51. | |
| BI 639667 | BI 639667 (compound 19n), a third azaindazole series compound, is a CCR1 antagonist, with an IC 50 of 1.8 nM in Ca 2+ flux assay [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CCR1 antagonist 8. CAS No. 1295298-26-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-120588. | |
| BI671800 | BI671800 is a CRTH2 antagonist. It is used to treat patients with asthma. It is associated with a small improvement in FEV1 in symptomatic controller-naïve asthma patients, and in patients on inhaled corticosteroid (ICS) therapy. Uses: Bi671800 is used to treat patients with asthma. Synonyms: AP-761; AP 761; AP761; 5-Pyrimidineacetic acid, 4, 6-bis (dimethylamino) -2-[[4-[[4- (trifluoromethyl) benzoyl]amino]phenyl]methyl]-; 2- (4, 6-Bis (dimethylamino) -2- (4- (4- (trifluoromethyl) benzamido) benzyl) pyrimidin-5-yl) acetic acid; BI-671800; BI 671800; BI671800. Grades: >98%. CAS No. 1093108-50-9. Molecular formula: C25H26F3N5O3. Mole weight: 501.51. | |
| Bi-6c9 | BI-6C9 is a highly specific BH3 interacting domain (Bid) inhibitor, which prevents mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protects the cells from mitochondrial apoptosis inducing factor (AIF) release and caspase-independent cell death in neurons. Uses: Designed for use in research and industrial production. Additional or Alternative Names: BI-6C9, N-[4-(4-aminophenyl)sulfanylphenyl]-4-[(4-methoxyphenyl)sulfonylamino]butanamide, N-[4-[(4-Aminophenyl)thio]phenyl]-4-[[(4-methoxyphenyl)sulfonyl]amino]-Butanamide, 791835-21-7, AGN-PC-00BBZS, SureCN3088138, B0186_SIGMA, AC1Q4C26, CTK8E8904, NCGC00165738-01. Product Category: Inhibitors. Appearance: Solid. CAS No. 791835-21-7. Molecular formula: C23H25N3O4S2. Mole weight: 471.59. Purity: 0.96. IUPACName: N-[4-(4-aminophenyl)sulfanylphenyl]-4-[(4-methoxyphenyl)sulfonylamino]butanamide. Canonical SMILES: COC1=CC=C(C=C1)S(=O)(=O)NCCCC(=O)NC2=CC=C(C=C2)SC3=CC=C(C=C3)N. Density: 1.368g/cm³. Product ID: ACM791835217. Alfa Chemistry ISO 9001:2015 Certified. | |
| BI-6C9 | ?97% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| BI-6C9 | BI-6C9 ( N-[4-[(4-Aminophenyl)thio]phenyl]-4-[[(4-methoxyphenyl)sulfonyl]amino]-Butanamide) is a tBid inhibitor that possesses antiapoptotic properties. Bid plays an essential role in matrine-induced AIF translocation. BI-6C9 also blocked matrine-induced AIF translocation detected by confocal microscopy. Bid inhibitor BI-6C9 was applied to confirm the essential role of Bid in cell death induced by matrine. Synonyms: N-[4-[(4-aminophenyl)thio]phenyl]-4-[[(4-methoxyphenyl)sulfonyl]amino]-butanamide. Grades: ≥98%. CAS No. 791835-21-7. Molecular formula: C23H25N3O4S2. Mole weight: 471.6. | |
| BI-7273 | BI-7273 is a potent BRD9 bromodomain inhibitor (Ki = 15.4 nM; IC50=19 nM). BI-7273 structurally related BRD7 bromodomain (IC50 = 117 nM) without effect against the BRD2 and BRD4 bromodomain or a panel of kinases. BI-7273 has potential for use in treating acute myeloid leukemia according to a study in vitro (EC50 = 1.4 μM). Uses: A potent brd9 bromodomain inhibitor for the treatment of leukemia. Synonyms: 4-{4-[(dimethylamino)methyl]-2,6-dimethoxyphenyl}-2-methyl-1,2-dihydro-2,7-naphthyridin-1-one; 4-(4-((Dimethylamino)methyl)-3,5-dimethoxyphenyl)-2-methyl-2,7-naphthyridin-1(2H)-one; 2,7-Naphthyridin-1(2H)-one, 4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methyl-; BI7273; BI 7273. Grades: >98%. CAS No. 1883429-21-7. Molecular formula: C20H23N3O3. Mole weight: 353.41. | |
| BI-7273 | BI-7273 is a selective, and cell-permeable BRD9 inhibitor, with an IC50 and a Kd of 19 and 0.75 nM; also shows high effect on BRD7, with an IC50 and a Kd of 117 nM and 0.3 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1883429-21-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100351. | |
| BI-749327 | BI-749327 is a potent, high selectivity and orally bioavailable TRPC6 antagonist, with IC50s of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively. BI-749327 is 85-fold more selective for mouse TRPC6 than TRPC3 and 42-fold versus TRPC7[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2361241-23-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-111925. | |
| BI 78D3 | BI 78D3 is a competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 = 280 nM) with > 100 fold selectivity over p38α and no effect on mTOR and PI-3K. BI 78D3 inhibits JNK interacting protein 1 (JIP1) binding to JNK (IC50 = 500 nM) and prevents JNK substrate phosphorylation. It blocks JNK-dependent Con A-induced liver damage and also restores insulin sensitivity in a mouse model of type II diabetes. Synonyms: JNK Inhibitor X; BI-78D3; BI78D3; BI 78D3; 4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2,4-dihydro-5-[(5-nitro-2-thiazolyl)thio]-3H-1,2,4-triazol-3-one. Grades: ≥99% by HPLC. CAS No. 883065-90-5. Molecular formula: C13H9N5O5S2. Mole weight: 379.37. | |
| BI 78D3 | BI 78D3. Group: Biochemicals. Grades: Purified. CAS No. 883065-90-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| BI-78D3 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BI-847325 | BI-847325 is an orally available dual inhibitor of mitogen-activated protein kinase kinase (MEK) and Aurora kinases, with potential antineoplastic activity. Upon oral administration, MEK/Aurora kinase inhibitor BI 847325 selectively binds to and inhibits the activity of MEK, which both prevents the activation of MEK-dependent effector proteins and inhibits growth factor-mediated cell signaling. BI 847325 also binds to and inhibits the activity of the Aurora kinases A, B and C which may disrupt the assembly of the mitotic spindle apparatus, prevent chromosome segregation, and inhibit both cellular division and proliferation in Aurora kinase-overexpressing tumor cells. Uses: Designed for use in research and industrial production. Additional or Alternative Names: BI-847325; BI 847325; BI847325. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1207293-36-4. Molecular formula: C29H28N4O2. Mole weight: 464.57. Purity: >98%. IUPACName: (Z)-3-(3-((4-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide. Canonical SMILES: O=C(NCC)C#CC1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(CN(C)C)C=C3)/C4=CC=CC=C4. Product ID: ACM1207293364-1. Alfa Chemistry ISO 9001:2015 Certified. | |
| BI-847325 | BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Synonyms: BI-847325; BI 847325; BI847325. Grades: 98%. CAS No. 1207293-36-4. Molecular formula: C29H28N4O2. Mole weight: 464.56. | |
| BI8622 | BI8622 is a specific inhibitor of the ubiquitin ligase HUWE1 with an IC50 of 3.1 ?M. BI8622 can decrease the protein expression levels of c-myc and glycolytic markers as well as immune modulatory markers after HUWE1 inhibition in triple-negative breast cancer (TNBC) cell lines. BI8622 significantly protects against cisplatin (HY-17394)-induced acute kidney injury (AKI). BI8622 significantly reduces the growth of multiple myeloma (MM) cell lines and induces cell cycle arrest. BI8622 can prevent HUWE1-dependent TTBK2 ubiquitination. BI8622 can be studied in research for various diseases including medulloblastoma, acute kidney injury, breast cancer and MM[1][2][3][4][5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1875036-74-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120929. | |
| BI8626 | BI8626 is a specific inhibitor of the ubiquitin ligase HUWE1 with an IC50 of 0.9 ?M[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1875036-75-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-120204. | |
| BI-87G3 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BI-882370 | BI-882370 is a highly potent, selective, orally active RAF inhibitor with IC50 of 0.4, 0.8 and 0.6 nM for BRAF V600E, BRAF WT and CRAF, respectively. BI-882370 is a potent and selective RAF inhibitor uniquely binding to the DFG-out conformation, whereas marketed BRAF inhibitors occupy the DFG-in conformation. BI-882370 inhibits proliferation of human BRAF-mutant melanoma cells with 100× higher potency (1-10 nmol/L) than vemurafenib. BI-882370 may provide an improved therapeutic window, enabling more pronounced and longer-lasting pathway suppression and thus resulting in improved efficacy. Synonyms: BI882370; BI 882370. Grades: ≥95%. CAS No. 1392429-79-6. Molecular formula: C28H33F2N7O2S. Mole weight: 569.7. | |
| BI 9321 | BI 9321 is a nuclear receptor-binding SET domain (NSD) 3 antagonist with IC50 of 1.2 μM. It is also selectively binds the PWWP1 domain of NSD3 with Kd of 166 nM. BI 9321 antagonizes the interaction of H3 with NSD3-PWWP1 in U2OS cells. High selectivity of BI-9321 was confirmed using in vitro assays and quantitative chemical proteomics. Cellular target engagement was confirmed with FRAP (Fluorescence Recovery After Photobleaching) and BRET (Bioluminescence Resonance Energy Transfer) at 1 μM. Synonyms: (4-(5-(7-Fluoroquinolin-4-yl)-1-methyl-1H-imidazol-4-yl)-3,5-dimethylphenyl)methanamine trihydrochloride. Grades: ≥98%. Molecular formula: C22H21FN4·3HCl. Mole weight: 469.81. | |
| BI-9321 trihydrochloride | BI-9321 trihydrochloride is a potent, selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist with a Kd value of 166 nM. BI-9321 trihydrochloride is inactive against NSD2-PWWP1 and NSD3-PWWP2. BI-9321 trihydrochloride specifically disrupts histone interactions of the NSD3-PWWP1 domain with an IC50 of 1.2 ?M in U2OS cells[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2387510-87-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114208A. | |
| BI-9564 | BI-9564 is a potent, selective and cell-permeable BRD9/BRD7 bromodomains inhibitor, with IC50s of 75 nM and 3.4 ?M and Kds of 14 nM and 239 nM, respectively. BI-9564 has an IC50 of > 100 ?M for BET family[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1883429-22-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100352. | |
| BI-9564 | BI-9564 is a potent and selective inhibitor of BRD9 and BRD7 bromodomains (Kds = 14.1 and 239 nM; IC50s = 75 nM and 3.4 μM, respectively), with selectivity for BRD9/7 over 48 other bromodomains, 324 kinases and 55 GPCRs. Synonyms: 4-(4-((dimethylamino)methyl)-2,5-dimethoxyphenyl)-2-methyl-2,7-naphthyridin-1(2H)-one; BI-9564; BI 9564; BI9564. CAS No. 1883429-22-8. Molecular formula: C20H23N3O3. Mole weight: 353.42. | |
| BI-9564 | ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BI-9627 | BI-9627 is a potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor (IC50 = 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays). BI-9627 displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 decreases autophagy in HTR-8/SVneo cells. BI-9627 can significantly reduce the pHi of human sperm and partially reverse the effect of DMA. BI-9627 prolongs Ca2+ recovery time in KO hiPSC-CMs. BI-9627 shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1204329-34-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18071. | |
| BI 99179 | BI 99179 is a potent and selective type I fatty acid synthase ( FAS ) inhibitor with an IC 50 of 79 nM. BI 99179 is a tool compound suitable for the in vivo validation of FAS as a target for lipid metabolism related diseases. BI 99179 exhibits significant exposure (both peripheral and central) upon oral administration in rats [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1291779-76-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16100. | |
| BIA 10-2474 | BIA 10-2474 is an inhibitor of fatty acid amide hydrolase ( FAAH ) with IC 50 values of 50 to 70mg/kg in various rat brain regions. Uses: Scientific research. Group: Signaling pathways. CAS No. 1233855-46-3. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19740. | |
| BIA10-2474 | This active molecular is a reversible FAAH (fatty acid amide hydrolase) inhibitor that increases levels of the neurotransmitter anandamide in the central nervous system and in peripheral tissues (except the brain and spinal cord) under the development of Bial-Portela & Ca. SA. BIA 10-2474 can interact with the human endocannabinoid system and was inpplicated in the treatment of a range of different medical conditions including anxiety, Parkinson's disease, chronic pain of multiple sclerosis, cancer, hypertension and obesity. Clinical trial with BIA 10-2474 was on-going. However, severe adverse events occurred in January 2016 affecting 5 patients, including leading to the death of one. Uses: Neurological disorders; pain; psychiatric disorders. Synonyms: BIA 10-2474; BIA-10-2474; BIA10-2474; N-cyclohexyl-N-methyl-4-(1-oxidopyridin-1-ium-3-yl)imidazole-1-carboxamide;UNII-5AP1ZW859M; SCHEMBL427970; 5AP1ZW859M; GTPL9001; DOWVMJFBDGWVML-UHFFFAOYSA-N. Grades: 98%. CAS No. 1233855-46-3. Molecular formula: C16H20N4O2. Mole weight: 300.36. | |
| BIA 2-093 | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| Biacangelicin | analytical standard. Group: Herbal medicinal products standards. | |
| Biacangelicol (Byakangelicol) | Biacangelicol (Byakangelicol). Group: Biochemicals. Alternative Names: Biacangelicol. Grades: Plant Grade. CAS No. 26091-79-2. Pack Sizes: 20mg. Molecular Formula: C17H16O6, Molecular Weight: 316.305. US Biological Life Sciences. | Worldwide |
| Biadamantylidene | Biadamantylidene. Group: Biochemicals. Grades: Highly Purified. CAS No. 30541-56-1. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C20H28. US Biological Life Sciences. | Worldwide |
| Bialamicol hydrochloride | Bialomicol is a synthetic bio-active chemical. Uses: A synthetic bio-active chemical. Synonyms: Bialamicol Hydrochloride; Bialamicol hydrochloride [USAN]; CAM 807; CAM-807; Camoform hydrochloride; CI 301; CI301; CI-301; NSC 6386;PAA 701 dihydrochloride; PAA-701; PAA701 dihydrochloride; SN 6771 dihydrochloride; UNII-VIQ3X36S8C;2-(diethylaminomethyl)-4-[3-(diethylaminomethyl)-4-hydroxy-5-prop-2-enylphenyl]-6-prop-2-enylphenol;dihydrochloride. Grades: ≥98%. CAS No. 3624-96-2. Molecular formula: C28H42Cl2N2O2. Mole weight: 509.556. | |
| Bialaphos | 10mg Pack Size. Group: Biochemicals, Building Blocks, Organics, Peptide Reagents, Research Organics & Inorganics. Formula: C11H22N3O6P. CAS No. 35597-43-4. Prepack ID 14973551-10mg. Molecular Weight 323.28. See USA prepack pricing. |  |
| Bialaphos | Bialaphos is a phosphorus-containing tripeptide produced by Streptomyces viridochromogenes and Str. hygroscopicus. It has anti-bacterial, anti-fungal activity, and has herbicidal effect. Synonyms: Bilanafos; Herby; Antibiotic SF 1293. Grades: >98%. CAS No. 35597-43-4. Molecular formula: C11H22N3O6P. Mole weight: 323.28. | |
| Bialaphos sodium | Bialaphos (SF-1293) sodium, an antibiotic , is an effective herbicide is a metabolite of Streptomyces hygroscopicus [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SF-1293 sodium. CAS No. 71048-99-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-122494A. | |
| Bialaphos sodium | A freely soluble herbicide synthesized by streptomyces hygroscopicus and streptomyces viridochromeogenes. CAS No. 71048-99-2. Molecular formula: C11H21N3NaO6P. Mole weight: 345.27. | |
| Bialaphos Sodium Salt | Bialaphos Sodium Salt is a tripeptide antibiotic that is employed in the transformation experiments of many species of plants that make use of the bar gene for selection. It is more effective than glufosinate in corn. In wheat, bialaphos was the most reliable selection criteria used to identify bar transformed plants. Group: Biochemicals. Alternative Names: (2S) -2-Amino-4- (hydroxy methyl phosphinyl) butanoyl-L-alanyl-L-alanine Monosodium Salt; γ - (Hydroxy methyl phosphinyl) -L- α -aminobutyryl-L-alanyl-L-alanine Monosodium Salt; Bilanafos Sodium Salt; Herbi-Ace; Herbie; MW 801; SF 1293. Grades: Highly Purified. CAS No. 71048-99-2. Pack Sizes: 25mg, 50mg, 100mg. Molecular Formula: C??H??N?NaO?P, Molecular Weight: 345.26. US Biological Life Sciences. | Worldwide |
| Bianntennary N-linked core pentasaccharide | Bianntennary N-linked core pentasaccharide is a pivotal compound assuming a momentous function in the examination of glycosylation motifs and their inherent physiological mechanisms. Through its utilization, one may delve into the intricate biosynthetic pathways and alterations conversant with N-linked glycans. Synonyms: GlcNAcβ1-2Manα1-6Man3-1Manα2-1βGlcNAc. Grades: ≥95%. Molecular formula: C34H58N2O26. Mole weight: 910.82. | |
| Bianthronyl | Bianthronyl. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (9,9'-Bianthracene)-10,10'(9H,9'H)-dione;9,10-Dianthrone;BIANTHRONYL;10,10'-DIHYDROBIANTHRONE;10,10'-DIHYDRODIANTHRONE;Anthrone dimer;10-(10-keto-9H-anthracen-9-yl)-10H-anthracen-9-one;10-(10-oxo-9H-anthracen-9-yl)-10H-anthracen-9-one. Product Category: Heterocyclic Organic Compound. CAS No. 434-84-4. Molecular formula: C28H18O2. Mole weight: 386.44. Purity: 0.96. IUPACName: 10-(10-oxo-9H-anthracen-9-yl)-10H-anthracen-9-one. Canonical SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C3C2=O)C4C5=CC=CC=C5C(=O)C6=CC=CC=C46. Density: 1.293g/cm³. Product ID: ACM434844. Alfa Chemistry ISO 9001:2015 Certified. | |
| Biapenem | Biapenem (CLI 86815; L 627; LJC 10627) a parenteral carbapenem antibacterial agent with a broad spectrum. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CLI 86815; L 627; LJC 10627. CAS No. 120410-24-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13573. | |
| Biapenem | An carbapenem antibacterial. Group: Biochemicals. Alternative Names: 6-[[(4R,5S,6S)-2-Carboxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium Inner Salt; Biapenern; Omegacin. Grades: Highly Purified. CAS No. 120410-24-4. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Biapenem | Biapenem is a carbapenem antibiotic with in vitro activity against anaerobes. Synonyms: Omegacin; Biapenern; L-627; L 627; L627. Grades: 98%. CAS No. 120410-24-4. Molecular formula: C15H18N4O4S. Mole weight: 350.39282. | |
| Biapenem | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopychiral molecules. Alternative Names: CL 186-815, L 627, LJC 10627, Omegacin, 6-[[(4R,5S,6S)-2-Carboxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5H-pyrazolo[1,2-a]-s-triazol-4-ium hydroxide, inner salt, Biapenem,6-[[(4R,5S,6S)-2-Carboxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium inner salt, 5H-Pyrazolo[1,2-a][1,2,4]triazol-4-ium, 6-[[2-carboxy-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-, inner salt, [4R-[4?,5?,6?(R*)]]-, 1-Azabicyclo[3.2.0]heptane, 5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium deriv., Biapenern, CL 186815. | |
| Biapenem USP | (4R,5S,6S)-3-[[(3S,5S)-5-[(Dimeth-ylamino)carbonyl]-3-pyrrolidinyl] thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2- carboxylic acid. antibiotic. Grades: USP. CAS No. 120410-24-4. Product ID: 2-08333. Molecular formula: C15H18N8O4S. Mole weight: 350.39. Purity: 0.99. |  |
| BIBB 515 | 2,3-Oxidosqualene cyclase (OSC) is an important enzyme in the biosynthesis of animal, plant, and fungal sterols. BIBB 515 is a selective and potent inhibitor of 2,3-oxidosqualene cyclase (OSC) with an ED50 value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively. It is concluded that the lipid-lowering effect of BIBB 515 is mainly the result of an inhibition of LDL production rather than due to an increase in LDL catabolism. OSC inhibitors may offer a novel approach for lipid-lowering therapy. Synonyms: BIBB-515; BIBB515. Grades: ≥98%. CAS No. 156635-05-1. Molecular formula: C22H21ClN2O2. Mole weight: 380.9. | |
| Bibenzyl | 1,2-Diphenylethane is a kind of widely used aromatic hydrocarbon compound. Synonyms: 2-phenylethylbenzene. CAS No. 103-29-7. Molecular formula: C14H14. Mole weight: 182.26. | |
| BIBF0775 | BIBF0775 is an inhibitor of transforming growth factor beta receptor I (TGFβRI) with an IC50 of 34 nM. Synonyms: (Z) -N-Ethyl-N-Methyl-2-Oxo-3- (Phenyl ( (4- (Piperidin-1-Ylmethyl) Phenyl) Amino) Methylene) Indoline-6-Carboxamide. Grades: ≥98% by HPLC. CAS No. 334951-90-5. Molecular formula: C31H34N4O2. Mole weight: 494.6. | |
| BIBN 4096 | BIBN 4096. Group: Biochemicals. Grades: Purified. CAS No. 204697-65-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| BIBO 3304 trifluoroacetate | BIBO 3304 trifluoroacetate. Group: Biochemicals. Grades: Purified. CAS No. 191868-14-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
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