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| Product | Description | |
|---|---|---|
| CK 666 | CK 666. Group: Biochemicals. Grades: Purified. CAS No. 442633-00-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| CK-666 | CK-666 is a cell-permeable actin-related protein Arp2/3 complex inhibitor (IC50=12 ?M). CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 442633-00-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-16926. |  |
| CK-666 | CK 666 has been found to be an inhibitor of the Arp2/3 complex and could also restrain actin polymerization. Synonyms: 442633-00-3; 2-fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide; CK-666; CK 666; CK-0944666; 2-Fluoro-N-(2-(2-methyl-1H-indol-3-yl)ethyl)benzamide; 3ukr; UXRKUKRXVWJFER-UHFFFAOYSA-N; Oprea1_850670; SCHEMBL3382638; CHEBI:78843; DTXSID70343330; 2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)-ethyl]-benzamide; CK666; NSC821559; STK766770; AKOS001725056; CK 666?; NSC-821559; NCGC00370920-01; AS-82972; CK-666, >=98% (HPLC), powder; DA-62359; HY-16926; CS-0012973; F81773; SR-01000536526; SR-01000536526-1; Q27147993; Z1038843750; CKH. Grade: ≥99% by HPLC. CAS No. 442633-00-3. Molecular formula: C18H17FN2O. Mole weight: 296.34. |  |
| CK-666 | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. |  |
| CK 683A | CK 683A is a bio-active chemical,but no detailed information has been published yet. Synonyms: CK 683A; CK683A; CK-683A. 1,7-Bis((1-adamantyl)carbamylguanidino)-4-methyl-4-azaheptane. Grade: 98%. CAS No. 83539-21-3. Molecular formula: C32H57N9O5S. Mole weight: 679.92. | |
| CK7 | CK7, a Cdk2/9 inhibitor, can be used for the synthesis of Nek1 inhibitor BSc5231 and BSc5367 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 507487-89-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103646. | |
| CK 869 | CK 869. Group: Biochemicals. Grades: Purified. CAS No. 388592-44-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| CK 869 | CK 869 has been found to inhibit actin polymerization as well as human and bovine actin-related protein 2/3 (Arp2/3) complex. Synonyms: CK-869; CK 869; CK869; CK-0157869; CK 0157869; CK0157869; 2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone. Grade: ≥98% by HPLC. CAS No. 388592-44-7. Molecular formula: C17H16BrNO3S. Mole weight: 394.28. | |
| CK-869 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| CK-869 | CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC50 of 7 ?M. Uses: Scientific research. Group: Signaling pathways. CAS No. 388592-44-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16927. | |
| CKD-516 | This active molecular is a tubulin polymerisation inhibitor which is applicated for solid cancer treatment. CKD-516 disruptes tubulin of the endothelial cytoskeleton selectively. In Jun 2012, a South Korea company, Chong Kun Dang initiated enrolment in a phase I trial for solid tumours treatment in South Korea. In Dec 2014, Phase-I clinical trials in Solid tumours in South Korea was on going. Uses: Solid tumours. Synonyms: CKD-516 HCl; CKD 516 HCl; CKD516 HCl; (2S)-2-amino-3-methyl-N-[4-[3-(1,2,4-triazol-1-yl)-4-(3,4,5-trimethoxybenzoyl)phenyl]-1,3-thiazol-2-yl]butanamide; hydrochloride; 1188371-47-2 (free base). Grade: 98%. CAS No. 1188371-47-2. Molecular formula: C26H28N6O5S. Mole weight: 536.6. | |
| CKD-516 HCl | CKD-516 is tubulin inhibitor for solid cancer, which was initiated phase 1 trial in Korea in 2010. CKD-516 selectively disrupted tubulin component of the endothelial cytoskeleton. Serial DCE-MRI showed a significant decrease in K-trans and IAUGC parameters from baseline at 4 h (39.9 % in K-trans; -45.0 % in IAUGC) and at 24 h (-32.2 % in K-trans; -36.5 % in IAUGC), and a significant recovery at 48 h (22.9 % in K-trans; 34.8 % in IAUGC) following administration of CKD-516 at a 0.7-mg/kg dose. When the tumors were stratified according to the initial K-trans value of 0.1, tumors with a high K-trans?>?0.1 which was indicative of having well-developed pre-existing vessels, showed greater reduction in K-trans and IAUGC values. On histologic examination, the degree of necrosis of treated tumors was significantly greater than that of untreated tumors. In summary, CKD-516 is an effective VDA which results in rapid vascular shutdown by targeting the tubulin component of tumor vessels and thus leads to necrosis. Synonyms: Valecobulin hydrochloride; CKD516 hydrochloride; CKD 516 hydrochloride. CAS No. 1240321-53-2. Molecular formula: C26H29ClN6O5S. Mole weight: 573.07. | |
| CKD-602 | CKD-602 Inhibitor. Uses: Scientific use. Product Category: T7551. CAS No. 213819-48-8. |  |
| CKD-711 | It is produced by the strain of Streptomyces sp. CK-4416. CKD-711 strongly inhibited mammalian α-glucosidase activity, but weakly inhibited mammalian α-amylase from microorganism and mammal, which was similar to acarbose in vivo and in vitro. Synonyms: 4-Deoxy-4-{[(1R,2R,3S,4R,5S,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)-7-oxabicyclo[4.1.0]hept-2-yl]amino}-α-D-glucopyranosyl-(1->4)-α-D-glucopyranosyl-(1->4)-D-glucopyranose. Molecular formula: C25H43NO20. Mole weight: 677.60. | |
| CKI 7 dihydrochloride | CKI 7 is a CK1 inhibitor, and also inhibits SGK, S6K1 and MSK1. In combination with SB 431542, CKI 7 was shown to induce retinal cell differentiation from human ESCs and iPSCs. Synonyms: CKI-7 dihydrochloride; N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulphonamide dihydrochloride. Grade: >98%. CAS No. 1177141-67-1. Molecular formula: C11H14Cl3N3O2S. Mole weight: 358.67. | |
| CKI-7 dihydrochloride | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| CKI-7 free base | CKI-7 free base is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC 50 of 6 μM and a K i of 8.5 μM. CKI-7 free base is a selective Cdc7 kinase inhibitor. CKI-7 free base also inhibits SGK , ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 free base has a much weaker effect on casein kinase II and other protein kinases [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 120615-25-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133028. | |
| CKI-7 free base | CKI-7 free base is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC50 of 6 μM and a Ki of 8.5 μM. CKI-7 free base also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). Uses: Found to have a potent inhibitory action against casein kinase 1 completely with respect to atp and a much weaker effect on casein kinase 2 and other protein kinases. Synonyms: CKI-7; CKI 7; 8-Isoquinolinesulfonamide, N-(2-aminoethyl)-5-chloro-. Grade: 95%. CAS No. 120615-25-0. Molecular formula: C11H12ClN3O2S. Mole weight: 285.75. | |
| c-KIT (544-end), active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?75% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| c-KIT (544-end, V654A), active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| c-KIT (D820E), active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| c-Kit-IN-2 | c-Kit-IN-2 is a c-Kit inhibitor with an IC50 of 82 nM, and has good antiproliferative activity against all the three GIST cell lines, GIST882, GIST430, and GIST48, with GI50s of 3, 1 and 2 nM, respectively. Synonyms: 1-(5-Ethyl-1,2-oxazol-3-yl)-3-[4-(2-{[6-(4-ethyl-1-piperazinyl)-4-pyrimidinyl]amino}-1,3-thiazol-5-yl)phenyl]urea; Urea, N-(5-ethyl-3-isoxazolyl)-N'-[4-[2-[[6-(4-ethyl-1-piperazinyl)-4-pyrimidinyl]amino]-5-thiazolyl]phenyl]-. Grade: ≥95%. CAS No. 2121515-37-3. Molecular formula: C25H29N9O2S. Mole weight: 519.62. | |
| c-Kit-IN-3 | c-Kit-IN-3 is a selective inhibitor of c-KIT kinase. c-Kit-IN-3 displays great potencies against most of the gain-of function mutations in the juxtamembrane domain, drugresistant mutations in the ATP binding pocket, and activation loops. Synonyms: c-Kit IN 3; c-Kit IN-3; c-Kit-IN 3. CAS No. 2363169-01-9. Molecular formula: C26H20ClF3N2O4. Mole weight: 516.90. | |
| c-Kit-IN-5-1 | c-Kit-IN-5 is potent inhibitor of c-Kit, with IC50s of 22 nM and 16 nM in kinase assay and cell assay, respectively. c-Kit-IN-5 shows more than 200-fold selectivity for c-Kit over KDR, p38, Lck, and Src. c-Kit-IN-5 also exhibits desirable pharmacokinetic properties[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1003311-62-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-18302. | |
| c-KIT (N822K), active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| c-KIT (T670E), active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| c-KIT (T670I), active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| c-KIT (Y823D), active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| CKK-E12 | CKK-E12 is a ionizable lipid in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based research. CKK-E12 is highly selective toward liver parenchymal cell in vivo. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 1432494-65-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134781. | |
| CL075 | CL075 is a thiazoloquinolone derivative that stimulates TLR8 in human peripheral blood mononuclear cells. It activates NF-κB and triggers preferentially the production of TNF-α and IL-12. CL075 seems also to induce the secretion of IFN-α through TLR7 but to a lesser extend. It induces the activation of NF-κB at 0.4 uM (0.1 ug/ml) in TLR8-transfected HEK293 cells, and ~ 10 times more CL075 is required to activate NF-κB in TLR7-transfected HEK293 cells. Group: Others. Mole weight: 243.33. Stability: Lyophilized product is stable 1 year at -20°C when properly stored. Resuspended CL075 should be aliquoted and stored at -20°C. Resuspended product is stable 6 months at -20°C. Avoid repeated freeze-thaw cycles. Appearance: Yellow lyophilized powder. Storage: Store at -20°C. CL075. Cat No: LIGC-007. |  |
| CL075 | CL075 is a thiazoloquinolone derivative that stimulates TLR8 in human peripheral blood mononuclear cells. Uses: Toll-like receptor agonists. Synonyms: CL 075; CL-075; Thiazolo[4,5-c]quinolin-4-amine, 2-propyl-; 2-Propylthiazolo[4,5-c]quinolin-4-amine; 3M 002; 3M-002; 3M002. Grade: ≥95%. CAS No. 256922-53-9. Molecular formula: C13H13N3S. Mole weight: 243.33. | |
| CL075 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| CL097 | CL097 is a human TLR7/8 and mouse TLR7 agonist. Synonyms: CL 097; CL-097; 3H-Imidazo[4,5-c]quinolin-4-amine, 2-(ethoxymethyl)-; 2-(Ethoxymethyl)-1H-imidazo[4,5-C]quinolin-4-amine. Grade: ≥95%. CAS No. 1026249-18-2. Molecular formula: C13H14N40. Mole weight: 242.28. | |
| CL097 | CL097, a potent TLR7 and TLR8 agonist, induces pro-inflammatory cytokines in macrophages[1]. CL097 induces NADPH oxidase priming, resulting in an increase of the fMLF-stimulated ROS production[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1026249-18-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128799. | |
| CL 218872 | CL 218872 has been found to be a benzodiazepine agonist and has been found to exhibit anxiolytic and anticonvulsant activities. Synonyms: CL 218872; CL218872; CL-218872; 3-Methyl-6-[-3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine. Grade: ≥99% by HPLC. CAS No. 66548-69-4. Molecular formula: C13H9F3N4. Mole weight: 278.24. | |
| CL 218872 | CL 218872 is a selective and orally active benzodiazepine of α1 subunit-containing GABA A receptor with a K i of 130 nM. CL 218872 exerts anxiolytic and anticonvulsant in vivo [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 66548-69-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103505. | |
| CL 218872 | CL 218872. Group: Biochemicals. Grades: Purified. CAS No. 66548-69-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| CL264 | CL264 is a small-molecule agonist of TLR7. Synonyms: Glycine, N-[4-[[6-amino-2-(butylamino)-7,8-dihydro-8-oxo-9H-purin-9-yl]methyl]benzoyl]-; N-[4-[[6-Amino-2-(butylamino)-7,8-dihydro-8-oxo-9H-purin-9-yl]methyl]benzoyl]glycine; CL 246; CL 264; CL-264; (4-((6-amino-2-(butylamino)-8-oxo-7,8-dihydro-9H-purin-9-yl)methyl)benzoyl)glycine. Grade: ≥95%. CAS No. 1510712-69-2. Molecular formula: C47H73N13O7S. Mole weight: 413.43. | |
| CL2A-SN 38 | CL2A-SN 38 is a drug-linker conjugate for ADC by using SN 38 (a DNA Topoisomerase I inhibitor), linked via CL2A. Synonyms: CL2A-SN-38. CAS No. 1279680-68-0. Molecular formula: C73H97N11O22. Mole weight: 1480.63. | |
| CL2A-SN-38 | CL2A-SN-38 is a agent-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody agent conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A-SN-38 uses hydrolyzable linker to deliver active agents within tumor cells and in the tumor microenvironment, resulting in bystander effects[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1279680-68-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128946. | |
| CL2-MMT-SN38 | CL2-MMT-SN38 is a derivative of SN-38, an anticancer drug that is an active metabolite of the topoisomerase I inhibitor Irinotecan. Synonyms: 4-((2S,5S)-5-benzyl-38-(4-((4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexane-1-carboxamido)methyl)-1H-1,2,3-triazol-1-yl)-2-(4-(((4-methoxyphenyl)diphenylmethyl)amino)butyl)-4,7,11-trioxo-9,15,18,21,24,27,30,33,36-nonaoxa-3,6,12-triazaoctatriacontanamido)benzyl ((S)-4,11-diethyl-9-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl) carbonate. Grade: ≥90%. CAS No. 1084888-82-3. Molecular formula: C102H122N12O24. Mole weight: 1900.13. | |
| CL307 | CL307 is an agonist of TLR7. Synonyms: Benzamide, 4-[[6-amino-2-(butylamino)-7,8-dihydro-8-oxo-9H-purin-9-yl]methyl]-N-[2-[[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]amino]-2-oxoethyl]-; CL 307; CL-307; N1-glycinyl[4-((6-amino-2-(butylamino)-8-hydroxy-9H-purin-9-yl)methyl)benzoyl]spermine; 4-((6-amino-2-(butylamino)-8-oxo-7,8-dihydro-9H-purin-9-yl)methyl)-N-(2-((3-((4-((3-aminopropyl)amino)butyl)amino)propyl)amino)-2-oxoethyl)benzamide; 4-[[6-Amino-2-(butylamino)-7,8-dihydro-8-oxo-9H-purin-9-yl]methyl]-N-[2-[[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]amino]-2-oxoethyl]benzamide. Grade: ≥95%. CAS No. 1548551-79-6. Molecular formula: C29H47N11O3. Mole weight: 597.76. | |
| CL 316243 | CL316243 is a highly potent selective β3-adrenoceptor agonist with a EC 50 of 3 nM, but is an extremely poor to β1/2- receptors [1].CL316243 is a effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate [2]. CL316243 has the potential for the treatment obesity, diabetes and urge urinary incontinence [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 138908-40-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116771A. | |
| CL-316243 | CL-316243 is a potent and highly selective β3-adrenoceptor agonist (EC50 = 3 nM) with > 10000-fold selective over β1 and β2 receptors. CL 316243 possesses anti-obesity and anti-diabetic effects due to increasing brown adipose tissue thermogenesis and metabolic rate, and consequently may be useful for treating obesity as well as non-insulin-dependent diabetes mellitus in obese persons, without causing excessive side effects. Synonyms: CL-316243; CL 316243; CL316243; 5-[(2R)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate; 138908-40-4 (CL-316243 sodium). Grade: >98%. CAS No. 183720-02-7. Molecular formula: C20H20ClNNa2O7. Mole weight: 419.794. | |
| CL 316243 disodium salt | The sodium salt form of CL 316243, which has been found to be a β3-adrenoceptor agonist and could probably decrease blood insulin as well as glucose levels. Synonyms: CL 316243 disodium salt; CL316243 disodium salt; CL-316243 disodium salt; 5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid disodium salt. Grade: ≥98% by HPLC. CAS No. 151126-84-0. Molecular formula: C20H18ClNNa2O7. Mole weight: 465.80. | |
| CL 316243 free acid | CL316243 free acid is a highly potent selective β3-adrenoceptor agonist with a EC 50 of 3 nM, but is an extremely poor to β1/2- receptors. CL316243 free acid is a effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate. CL316243 free acid has the potential for the treatment obesity, diabetes and urge urinary incontinence [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 183720-02-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-116771. | |
| CL316243 Hydrate (Disodium 5- [ (2R) -2- [ [ (2R) -2- (3-Chlorophenyl) -2-hydroxyethyl] amino] propyl] -1, 3-benzodioxole-2, 2-dicarboxylate Hydrate) | A very potent agonist highly selective for beta-3 adrenoceptors (EC50 = 3nM). Widely used to assess the functional roles of beta-3 adrenoceptors in glucose homeostasis, thermogenesis, obesity, cardiac functions, retinal neurotoxicity, and tissue inflammation. Group: Biochemicals. Grades: Highly Purified. CAS No. 138908-40-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| CL-316243 sodium | CL-316243 is a highly selective β3-adrenoceptor agonist with EC50 value of 3 nM; > 10000-fold selective over β1 and β2 receptors. CL-316243 can restore the expression of down-regulated fatty acid oxidation genes in type 2 diabetic mice and enhance insulin-stimulated glucose disposal in nonobese rats. Preclical trials for the treatment of Obesity, Overactive bladder and Type 2 diabetes mellitus were discontinued. Uses: Obesity; overactive bladder; type 2 diabetes mellitus. Synonyms: CL-316243 sodium; CL 316243 sodium; CL316243 sodium; disodium; 5-[(2R)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate; BTA 243; HP 186; BTA243; HP186; BTA-243; HP-186. Grade: 98%. CAS No. 138908-40-4. Molecular formula: C20H18ClNNa2O7. Mole weight: 465.79. | |
| CL-387785 | CL-387785, also known as EKI-785, is an irreversible inhibitor of EGF-receptor (EGFR) kinase activity in vivo (IC50 = 250-490 pM). CL-387785 covalently bound to EGF-R. It also specifically inhibited kinase activity of the protein (IC50 = 370+/-120 pM), blocked EGF-stimulated autophosphorylation of the receptor in cells (ic50 approximately 5 nM), inhibited cell proliferation (IC50 = 31-125 nM) primarily in a cytostatic manner in cell lines that overexpress EGF-R or c-erbB-2, and profoundly blocked the growth of a tumor that overexpresses EGF-R in nude mice (when given orally at 80 mg/kg/day for 10 days, daily). CL-387,785 is useful for studying the interaction of small molecules with EGF-R and may have clinical utility. Uses: Protein kinase inhibitors. Synonyms: CL-387785; CL 387785; CL-387,785; CL387785; EKI-785; EKI 785; EKI785. Grade: 0.98. CAS No. 194423-06-8. Molecular formula: C18H13BrN4O. Mole weight: 381.233. | |
| CL-387,785 - CAS 194423-06-8 | A cell-permeable and irreversible inhibitor of EGF-receptor (EGFR) kinase activity in vivo (IC?? = 250-490 pM) as well as EGF-stimulated autophosphorylation of tyrosine residues in the EGFR in vivo (IC?? = 5 nM). Group: Fluorescence/luminescence spectroscopy. | |
| CL 43356 | CL 43356 is a synthetic bio-active chemical. Uses: A synthetic bio-active chemical. Synonyms: CL 43356; CL 43356; CL 43356; CL-43,356; O,O-dimethyl 1,3-dithiolan-2-ylidenephosphoramidothioate; N-dimethoxyphosphinothioyl-1,3-dithiolan-2-imine. Grade: ≥98%. CAS No. 3572-55-2. Molecular formula: C5H10NO2PS3. Mole weight: 242.96. | |
| Cl-4AS-1 | Cl-4AS-1 is a mouse mammary tumor virus (MMTV) promoter and represses MMP1 promoter activity. It also inhibits 5α-Reductase type I and II with IC50 values of 6 and 10 nM respectively, as well as is a potent steroidal androgen receptor agonist with IC50 value of 12 nM. It mimics the action of 5α-dihydrotestosterone (DHT). Synonyms: (4aα,4bβ,6aα,7α,9aβ,9bα,11aβ)-N-(2-Chlorophenyl)-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1,4,6a-trimethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxamide. Grade: ≥99% by HPLC. CAS No. 188589-66-4. Molecular formula: C26H33ClN2O2. Mole weight: 441.01. | |
| Cl-4AS-1 | Cl-4AS-1. Group: Biochemicals. Grades: Purified. CAS No. 188589-66-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| CL5D | CL5D is a SIRT6 activator which activates SIRT6 deacetylase activity. Grade: >98%. CAS No. 2488745-53-3. Molecular formula: C29H11Cl7N2O6. Mole weight: 731.57. | |
| CL 614 | CL 614, a derivative of cAIMP, is a novel STING (stimulator of interferon genes)-activating synthetic CDN. Synonyms: cAIMP Difluor; CL614; CL-614; 3'-Adenylic acid, 2'-deoxy-2'-fluoroinosinylyl-(3'→5')-2'-deoxy-2'-fluoro-, cyclic nucleotide; c-(2'FdAMP-2'FdIMP) sodium salt; 9-((2R,3R,3aR,7aR,9R,10R,10aR,14aR)-9-(6-amino-9H-purin-9-yl)-3,10-difluoro-5,12-dihydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9]tetraoxa[2,8]diphosphacyclododecin-2-yl)-1,9-dihydro-6H-purin-6-one. CAS No. 1951464-78-0. Molecular formula: C20H21F2N9O11P2. Mole weight: 663.38. | |
| CL656 | CL656 is an agonist of stimulator of interferon genes (STING) for treating cancer. Synonyms: c-[2'FdAMP(S)-2'FdIMP(S)]; cAIM(PS)2 Difluor (Rp/Sp); Adenosine, 2'-deoxy-2'-fluoro-5'-O-(hydroxymercaptophosphinyl)-P-thioinosinylyl-(3'→5')-2'-deoxy-2'-fluoro-, cyclic nucleotide; CL 656; CL-656; (Rp/Sp) c-[2'FdAM(PS)-2'FdIM(PS]); 9-((2R,3R,3aR,7aR,9R,10R,10aR,14aR)-9-(6-amino-9H-purin-9-yl)-3,10-difluoro-12-hydroxy-5-mercapto-5-oxido-12-sulfidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9]tetraoxa[2,8]diphosphacyclododecin-2-yl)-1,9-dihydro-6H-purin-6-one. Grade: >98%. CAS No. 1951464-79-1. Molecular formula: C20H21F2N9O9P2S2. Mole weight: 695.51. | |
| CL 82,198 | CL 82,198 is a selective inhibitor of human collagenase-3, also known as matrix metalloproteinase-13 (MMP-13). It doesn't have effect against MMP-1, MMP-9 or TNF-α converting enzyme. CL 82,198 is also used to evaluate the role of MMP-13 in diverse processes, including cancer cell migration, acute lung injury, and joint degeneration associated with osteoarthritis. Synonyms: CL-82198; N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide. Grade: ≥95%. CAS No. 307002-71-7. Molecular formula: C17H22N2O3. Mole weight: 302.4. | |
| CL-82198 | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. | |
| CL-82198 | CL-82198 is a selective inhibitor of MMP-13. CL-82198 binds to the entire S1 pocket of MMP-13, which is the basis for its selectivity towards MMP-13 and the lack of inhibitory activities against other MMPs[1][2]. CL-82198 is a pharmacologic treatment for preventing osteoarthritis (OA) progression[4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 307002-71-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100359. | |
| CL-82198 - CAS 1188890-36-9 | A selective inhibitor of MMP-13 (IC?? = 10 μM). Group: Fluorescence/luminescence spectroscopy. | |
| CL 82198 hydrochloride | CL 82198 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1188890-36-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| CL 82198 hydrochloride | The hydrochloride salt form of CL 82198, an inhibitor of MMP-13, has been found to restrain in vitro invasion by the human pituitary adenoma cell line HP75. Synonyms: CL 82198 hydrochloride; CL82198 hydrochloride; CL-82198 hydrochloride; N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide hydrochloride. Grade: ≥98% by HPLC. CAS No. 1188890-36-9. Molecular formula: C17H23N2O3.HCl. Mole weight: 338.83. | |
| ClAc-Gly-OH | ClAc-Gly-OH. Group: Biochemicals. Alternative Names: Chloracetyl glycine; (2-Chloro-acetylamino)-acetic acid. Grades: Highly Purified. CAS No. 6319-96-6. Pack Sizes: 10g, 25g. US Biological Life Sciences. | Worldwide |
| ClAc-Gly-OH | ClAc-Gly-OH. Synonyms: Chloracetyl glycine(2-Chloro-acetylamino)-acetic acid. Grade: ≥ 99% (TLC). CAS No. 6319-96-6. Molecular formula: C4H6ClNO3. Mole weight: 151.55. | |
| ClAc-Gly-OH 98+% (TLC) | ClAc-Gly-OH 98+% (TLC). Group: Biochemicals. Grades: Reagent Grade. CAS No. 6319-96-6. Pack Sizes: 5g, 25g. US Biological Life Sciences. | Worldwide |
| Cladinose | Cladinose, an imperative chemical modification present in the macrolide category of antibacterial medications, demonstrates its excellence in combating Gram-positive bacteria, even the drug-resistant variants. With its pivotal role, Cladinose actively treats bacterial infections involving pneumonia, respiratory tract infections, skin and soft tissue infections, as well as selective sexually transmitted diseases. Notably, the inclusion of Cladinose remarkably enhances the efficiency and potency of these antibiotics, thereby advancing their therapeutic outcomes. Synonyms: L-Cladinose; 2,6-Dideoxy-3-C-methyl-3-O-methyl-ribo-hexose; Azithromycin Impurity 4; (4R,5S,6S)-4-Methoxy-4,6-dimethyltetrahydro-2H-pyran-2,5-diol; 3-C,3-O-Dimethyl-2,6-dideoxy-D-ribo-hexose. Grade: ≥95%. CAS No. 470-12-2. Molecular formula: C8H16O4. Mole weight: 176.21. | |
| Cladospirone bisepoxide | It is produced by the strain of Cladosporium sp. F-24707. Cladospirone bisepoxide has the ability to inhibit yeast, filamentous fungi, and bacterial, and can inhibit germination of Lepidium sativum at low concentrations. Synonyms: Cladospirone bisepoxide. CAS No. 155866-40-3. Molecular formula: C20H14O7. Mole weight: 366.32. | |
| Cladospirone Bisepoxide (Palmarumycin C13, Diepoxin zeta, Antibiotic Sch53514) | Antibiotic. Antibacterial and antifungal. Antitumor compound. Germination inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 152607-03-9, 155866-40-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Cladospolide A | It is produced by the strain of Cladosporium sp. FT-0012. Cladospolide A has little antibacterial activity. Synonyms: (-)-Cladospolide A; Oxacyclododec-3-en-2-one, 5,6-dihydroxy-12-methyl-, (3E,5R,6S,12R)-. CAS No. 77663-54-8. Molecular formula: C12H20O4. Mole weight: 228.28. | |
| Cladospolide B | It is produced by the strain of Cladosporium sp. FT-0012. Cladospolide B has little antibacterial activity. Synonyms: 4,5-di-epi-Cladospolide C. CAS No. 96443-55-9. Molecular formula: C12H20O4. Mole weight: 228.28. | |
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