A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the suppliers website for prices or more information.
| Product | Description | |
|---|---|---|
| CAY10621 | Sphingosine kinase (SphK) is a conserved lipid kinase that catalyzes formation sphingosine-1-phosphate (S1P) from the precursor sphingolipid sphingosine. The two known kinases, sphingosine kinase 1 (SphK1) and sphingosine kinase 2 (SphK2), have different developmental and tissue expression patterns, suggesting that they have distinct physiological functions. CAY10621 is an inhibitor of SPHK1 with IC50 of 3.3 μM. It is selective for SphK1 over Sph2 at 10 μM and PKC at concentrations less than 100 μM. CAY10621 inhibits SphK1 activity by 70% in U937 cells at 5 μM. Synonyms: SKI 5C; SPHK1 Inhibitor 5C; CAY 10621; CAY-10621. Grades: ≥98%. CAS No. 120005-55-2. Molecular formula: C26H45NO4. Mole weight: 435.6. |  |
| CAY10622 | Rho-associated protein kinase (ROCK) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine kinases. It is involved mainly in regulating the shape and movement of cells by acting on the cytoskeleton. Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions. CAY10622 is a potent, ureidobenzamide inhibitor of ROCK-I and ROCK-II kinases with IC50 values of 6 and 4 nM, respectively. Synonyms: CAY 10622; CAY-10622. Grades: ≥98%. CAS No. 1038549-25-5. Molecular formula: C25H25N5O3. Mole weight: 443.5. | |
| CAY10626 | Phosphatidylinositol 3-kinases (PI3K) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. PI3K catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. CAY10626 demonstrates IC50 values of <3 and 13 nM for MDA361 (breast) and PC3 (prostate) cancer cell lines, respectively. Synonyms: CAY 10626; CAY-10626. Grades: ≥98%. CAS No. 1202884-94-3. Molecular formula: C31H35F3N8O3. Mole weight: 624.7. | |
| CAY10638 | Peroxisome proliferator-activated receptor gamma (PPARγ), also known as the glitazone receptor, or NR1C3, is a type II nuclear receptor that in humans is encoded by the PPARG gene. Thiazolidinediones (TZDs) are a class of PPARγ agonists that have potent 15-PGDH inhibitory activity. CAY10638 is a TZD derivative that inhibits 15-PGDH activity with IC50 of 31 nM. Synonyms: CAY 10638; CAY-10638. Grades: ≥98%. CAS No. 1221413-57-5. Molecular formula: C16H13NO3S2. Mole weight: 331.4. | |
| CAY10640 | Soluble epoxide hydrolase (sEH) is a bifunctional enzyme that in humans is encoded by the EPHX2 gene. sEH is a member of the epoxide hydrolase family. CAY10640 is a 1-aryl-3-(1-acylpiperidin-4-yl)urea analog that inhibits recombinant human and mouse sEH with IC50 values both equal to 0.4 nM. Synonyms: sEHi; Soluble Epoxide Hydrolase Inhibitor; CAY 10640; CAY-10640. Grades: ≥98%. CAS No. 1208549-68-1. Molecular formula: C17H20F3N3O3. Mole weight: 371.4. | |
| CAY10649 | Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme that in humans is encoded by the ALOX5 gene. 5-LO initiates the synthesis of (LTs) from arachidonic acid, primarily in certain leukocyte populations. CAY10649 is a thiazolinone compound that demonstrates direct inhibition of 5-lipoxygenase (5-LO) product formation in intact polymorphonuclear leukocytes (PMNL) with IC50 of 0.28 μM. Synonyms: CAY 10649; CAY-10649. Grades: ≥98%. CAS No. 1272519-89-7. Molecular formula: C17H12ClNO2S. Mole weight: 329.8. | |
| CAY10650 | Cytosolic phospholipase A2α (cPLA2α) specifically catalyzes the hydrolysis of arachidonic acid from the sn-2-ester position of membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes, both important mediators of the inflammatory process. CAY10650 is a highly potent (IC50 = 12 nM) cPLA2α inhibitor. It demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis. Synonyms: CAY 10650; CAY-10650. Grades: >98%. CAS No. 1233706-88-1. Molecular formula: C28H25NO6. Mole weight: 471.5. | |
| CAY10669 | P300/CBP-associated factor (PCAF), also known as K(lysine) acetyltransferase 2B (KAT2B), is a co-activator of p53-target genes and moreover it regulates p53 activity by acetylating K320, which promotes p53-dependent p21 transcription and cell cycle arrest during DNA damage. CAY10669 is an inhibitor of the histone acetyltransferase PCAF, which displays 2-fold improvement in inhibitory potency over anacardic acid. Synonyms: CAY 10669; CAY-10669. Grades: ≥98%. CAS No. 1243583-88-1. Molecular formula: C20H22O4. Mole weight: 326.4. | |
| CAY10677 | Isoprenylcysteine Carboxyl Methyltransferase (ICMT) is a protein coding gene. Diseases associated with ICMT include Hallermann-Streiff syndrome and Legionnaire disease. CAY10677 is an analog of the ICMT inhibitor cysmethynil that was developed for improved solubility and cell permeability. It inhibits ICMT with an IC50 value of 0.86 μM and demonstrates nearly 10-fold more potent antiproliferative activity than cysmethynil on human breast cancer MDA-MB-231 cells and human prostate cancer PC3 cells. Synonyms: Icmt Inhibitor 15; CAY 10677; CAY-10677. Grades: ≥98%. CAS No. 1443253-20-0. Molecular formula: C25H37N5. Mole weight: 407.6. | |
| CAY10678 | Microsomal prostaglandin E synthase-1 (mPGES-1) or Prostaglandin E synthase is an enzyme that in humans is encoded by the PTGES gene. The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The IC50s of mPGES-1 inhibitor are 900 nM for human and 90 nM for rat. CAY10678 is a selective microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor. Synonyms: mPGES-1 Inhibitor III; CAY 10678; CAY-10678. Grades: ≥98%. CAS No. 1268709-57-4. Molecular formula: C23H34N4O. Mole weight: 382.5. | |
| CAY10680 | The monoamine oxidases A and B are the products of two abutting X-linked genes, and play an important role in the metabolism of biogenic amines in the central nervous system. Inhibition of MAO-B is considered as a strategy to treat Parkinson's disease. CAY10680 is a benzothiazinone compound that selectively inhibits MAO-B with IC50 = 34.9 nM in human. The blockade of adenosine A2A receptors has emerged as a potential treatment for Parkinson's disease. CAY10680 has been shown to abolish cAMP accumulation in CHO cells transfected with adenosine A2A receptors. It can selectively inhibits with Ki of 39.5 nM in human. Synonyms: CAY 10680; CAY-10680. Grades: ≥98%. CAS No. 1439488-21-7. Molecular formula: C18H16N2O2S. Mole weight: 324.4. | |
| CAY10681 | NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. CAY10681 is an orally active, small molecule that inhibits p53-MDM2 interaction and NF-κB pathway thus inhibiting tumor growth. It also inhibits phosphorylation of IκBα and dose-dependently reduces nuclear accumulation of p65. Synonyms: CAY 10681; CAY-10681. Grades: ≥98%. CAS No. 1542066-69-2. Molecular formula: C30H26BrN5O. Mole weight: 552.5. | |
| CAY10682 | The MDM2 protein is a negative regulator of p53. After binding to p53, it inhibits its transcriptional activity, favours its nuclear export and stimulates its degradation. The MDM2-TP53 pathway is a tumor-suppressor pathway that is often disrupted in cancer. CAY10682 is a pyrrolo[3,4c]pyrazole derivative that inhibits the p53-Mdm2 interaction as potently as (±)-nutlin-3 with Ki of 83 nM. It also blocks the growth of cancer cells with IC50 of 2-6 μM in vitro and inhibits the growth of A549 cell xenografts in mice. Synonyms: CAY 10682; CAY-10682. Grades: ≥98%. CAS No. 1542066-74-9. Molecular formula: C30H25BrFN5O. Mole weight: 570.5. | |
| CAY10683 | Santacruzamate A (CAY10683) is a potent and selective HDAC inhibitor with IC50 of 119 pM for HDAC2, >3600-fold selectivity over other HDACs. Uses: Histone deacetylase inhibitors. Synonyms: CAY10683; CAY-10683; CAY 10683; Santacruzamate A. Grades: >98%. CAS No. 1477949-42-0. Molecular formula: C15H22N2O3. Mole weight: 278.35. | |
| CAY10684 | Prostaglandin E2 receptor 4 (EP4) is a prostaglandin receptor for prostaglandin E2 (PGE2) encoded by the PTGER4 gene in humans. EP4 is a G protein-coupled receptor, which plays important roles in bone formation and resorption. CAY10684 is an EP4 receptor agonist. It displays more than 1,000-fold selectivity for EP4 over other EP receptors. Synonyms: CAY 10684; CAY-10684; 7-((2R)-2-((E)-3-(4'-Chloro-2'-methyl-[1,1'-biphenyl]-3-yl)-3-hydroxyprop-1-en-1-yl)-5-oxopyrrolidin-1-yl)heptanoic acid. Grades: ≥98%. CAS No. 493035-81-7. Molecular formula: C27H32ClNO4. Mole weight: 470. | |
| CAY10685 | CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating the Gcn5 network. Histone Acetyltransferase (HAT) inhibitor modulating Gcn5 network. CAY10685 is a cell-active analog of the lysine acetyltransferase inhibitor CPTH2 that contains an alkyne moiety. It can inhibit N-acetyltransferase, which shows potential applicaiton in studying the changes in nuclear architecture associated with cancer and certain laminopathies. Synonyms: CAY 10685; CAY-10685. Grades: ≥98%. CAS No. 1613116-16-7. Molecular formula: C17H16ClN3S. Mole weight: 329.8. | |
| CAY10698 | Platelet-type 12-lipoxygenase (12-LO) catalyzes the formation of 12-HpETE from arachidonic acid, which has been found to be expressed in various tumor cells. CAY10698 is an inhibitor of 12-LO with an IC50 value of 5.1 uM. It shows potenital applicaiton in biological characterization for development of potential 12-LO inhibitors. Synonyms: CAY 10698; CAY-10698. Grades: ≥98%. CAS No. 684236-01-9. Molecular formula: C17H17N3O4S2. Mole weight: 391.5. | |
| CAY10700 | Microsomal prostaglandin E synthase-1 (mPGES-1) or Prostaglandin E synthase is an enzyme that in humans is encoded by the PTGES gene. The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. CAY10700 is a novel selective and orally bioavailable inhibitor of mPGES-1 with IC50 of 0.24 μM for human whole blood assay. Uses: Enzyme inhibitors. Synonyms: mPGES-1 Inhibitor-1; CAY 10700; CAY-10700. Grades: ≥98%. CAS No. 1381846-21-4. Molecular formula: C16H19ClN4O2. Mole weight: 334.8. | |
| CAY10704 | Hepatitis C is a liver infection caused by the hepatitis C virus (HCV). It is a blood-borne virus, which can cause both acute and chronic hepatitis. CAY10704 is a potent inhibitor of hepatitis C virus (HCV) infection with EC50 of 17 nM. It displays good pharmacokinetics in mice with preferential liver distribution without significant hepatotoxicity. CAY10704 is also selective for HCV over dengue virus with EC50 of 4.62 μM. Synonyms: CAY 10704; CAY-10704. Grades: ≥98%. CAS No. 101784-44-5. Molecular formula: C18H20Cl2N2. Mole weight: 335.3. | |
| CAY10711 | CAY10711 is a substituted diamine that produces rapid bactericidal activity against both Gram-positive and Gram-negative bacteria. It can reduce biofilm formation and promotes biofilm dispersal in P. aeruginosa. CAY10711 displays MIC99 values of 2.9, 11.5, 2.9, and 2.9 μM against S. aureus RN4220, P. aeruginosa PAO1, E. coli ANS1, and MRSA 10082B, respectively. Synonyms: CAY 10711; CAY-10711. Grades: ≥95%. CAS No. 1666171-29-4. Molecular formula: C41H54N6S2. Mole weight: 695. | |
| CAY10717 | CAY10717 is a multi-targeted kinase inhibitor that exhibits greater than 40% inhibition of 34 of 104 kinases in an enzymatic assay at 100 nM. CAY10717 is highly cytotoxic against a cancer cell panel that includes chemotherapy-sensitive and -resistant cell lines (EC50s = 0.4-158 nM). It also inhibits the growth of human umbilical vein endothelial cells (HUVECs) with EC50 of 34 nM. Synonyms: CAY 10717; CAY-10717. Grades: ≥95%. CAS No. 1240322-54-6. Molecular formula: C29H25F3N6O3. Mole weight: 562.5. | |
| CAY10719 | ABCG2 is a constitutively expressed ATP-binding cassette (ABC) transporter that protects many tissues against xenobiotic molecules. CAY10719 is a selective inhibitor of the breast cancer resistance protein ABCG2 with IC50 of 0.23 μM. It has been shown to reverse the ABCG2-mediated resistance toward SN 38 and inhibit ATPase activity. Synonyms: CAY 10719; CAY-10719. Grades: ≥98%. CAS No. 1942919-63-2. Molecular formula: C25H20Cl2N2O2. Mole weight: 451.3. | |
| CAY10721 | Sirtuins (SIRTs) are a family of proteins that regulate cellular health. Sirtuins play a key role in regulating cellular homeostasis. SIRT1 Activator 3 is a member of the sirtuins (SIRTs), which is a distinctive class of trichostatin A-insensitive lysyl-deacetylases. CAY10721 is an inhibitor of SIRT3. It is a class III HDAC (39% SIRT3 inhibition at 200 μM). Synonyms: CAY 10721; CAY-10721. Grades: ≥98%. CAS No. 848688-62-0. Molecular formula: C18H13N3O3S. Mole weight: 351.4. | |
| CAY10722 | Sirtuins (SIRTs) are a family of proteins that regulate cellular health. Sirtuins play a key role in regulating cellular homeostasis. SIRT1 Activator 3 is a member of the sirtuins (SIRTs), which is a distinctive class of trichostatin A-insensitive lysyl-deacetylases. CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 μM). Synonyms: CAY 10722; CAY-10722. Grades: ≥98%. CAS No. 388086-13-3. Molecular formula: C21H14Cl2N2O2. Mole weight: 397.3. | |
| CAY10729 trifluoroacetate salt | Peptidyl Arginine Deiminases (PADs) perform post-translational deiminations of proteins. PADs are calcium-dependent enzymes that catalyze the conversion of L-arginine residues to L-citrulline. CAY10729 is a tetrazole derivative of the PAD inhibitor Cl-amidine that selectively inhibits PAD1 over PAD2, PAD3, and PAD4 (kinact/KI = 162,200, 60,000, 17,500, and 25,400 M-1min-1 for PAD1-4, respectively). Synonyms: CAY 10729; CAY-10729. Grades: ≥70%. Molecular formula: C19H26ClN7O3·xCF3COOH. Mole weight: 435.91. | |
| CAY10734 | Sphingosine-1-phosphate receptor (S1P) modulators are a class of drugs used as immunomodulators, most notably in cases of multiple sclerosis. CAY10734 is an agonist of sphingosine-1-phosphate receptor 1 (S1P1) with IC50=0.6 nM). It selectively binds S1P1 over S1P2, S1P3, and S1P4 receptors (IC50s = >10,000, 12,000, and 70 nM, respectively) but does also bind S1P5 receptors (IC50 = 1 nM) in radioligand binding assays. Synonyms: CAY 10734; CAY-10734. Grades: ≥98%. CAS No. 635701-59-6. Molecular formula: C23H25N3O3. Mole weight: 391.5. | |
| CAY10739 | Sphingosine-1-phosphate receptor (S1P) modulators are a class of drugs used as immunomodulators, most notably in cases of multiple sclerosis. CAY10739 is a soft-drug agonist of the sphingosine-1-phosphate receptor 1 (S1P1) with IC50=25.12 nM in a β-arrestin recruitment assay, which was designed to prevent systemic effects following topical application. It is selective for S1P1 over S1P2, S1P3, and S1P4 (IC50s = 1,000, >10,000, >10,000 nM, respectively). Synonyms: CAY 10739; CAY-10739. Grades: ≥98%. Molecular formula: C23H24N2O3S. Mole weight: 408.51. | |
| Cayenne Pepper Powder | Cayenne Pepper Powder. |  CA, FL & NJ |
| Caylin-2 | Caylin-2, a Nutlin-3 analog, is a MDM2 inhibitor. Caylin-2 can bind to Bcl-X L [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1392830-09-9. Pack Sizes: 1 mg. Product ID: HY-117585. |  |
| cAzapentacene polysulfonate sodium | cAzapentacene polysulfonate sodium. Group: Biochemicals. Alternative Names: Phacolysine sodium salt. Grades: Highly Purified. Pack Sizes: 1g, 2g, 5g, 10g, 25g. US Biological Life Sciences. |  Worldwide |
| CAzomethine-H monosodium salt monohydrate | CAzomethine-H monosodium salt monohydrate. Group: Biochemicals. Grades: Highly Purified. CAS No. 206752-32-1. Pack Sizes: 10g, 25g, 50g, 100g, 250g. Molecular Formula: C17H12NNaO8S2·H2O. US Biological Life Sciences. | Worldwide |
| CB10-277 | CB10-277 is a synthetic derivative of dimethylphenyl-triazene related to dacarbazine, with antineoplastic properties. Related to the agent dacarbazine, CB10-277 is converted in vivo to a monomethyl triazene form that alkylates DNA, resulting in inhibition of DNA replication and repair; in addition, this agent may act as a purine analogue, resulting in inhibition of DNA synthesis, and may interact with protein sulfhydryl groups. Uses: Antineoplastic agents. Synonyms: CB10-277; CB10 277; CB10277; 1-p-carboxy-3,3-dimethylphenyltriazine. CAS No. 7203-91-0. Molecular formula: C9H11N3O2. Mole weight: 193.21. | |
| CB-103 | CB-103 is a γ-secretase inhibitor. CB-103 inhibits Notch signaling in primary human T cell acute lymphoblastic leukemia and other Notch-dependent human tumor cell lines, and concomitantly induces cell cycle arrest and apoptosis, thereby impairing proliferation, including in GSI-resistant human tumor cell lines with chromosomal translocations and rearrangements in Notch genes. CB-103 produces Notch loss-of-function phenotypes in flies and mice and inhibits the growth of human breast cancer and leukemia xenografts, notably without causing the dose-limiting intestinal toxicity associated with other Notch inhibitors. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CB-103; CB 103; CB103. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 218457-67-1. Molecular formula: C15H18N2O. Mole weight: 242.32. Purity: >98%. IUPACName: 5-Amino-2-(4-tert-butylphenoxy)pyridine. Canonical SMILES: CC(C)(C)C1=CC=C(C=C1)OC2=NC=C(C=C2)N. Product ID: ACM218457671-1. Alfa Chemistry ISO 9001:2015 Certified. Categories: CB-13. |  |
| CB181963 | CB181963 shows excellent activity against MRSA strains resistant to other cephalosporins in both planktonic and biofilm cultures. It is a potent antistaphylococcal agent with better activity against MRSA. It may play a role in the treatment of staphylococcal infections, including those caused by MRSA and in the prophylaxis of biofilm-associated MSSA and MRSA infections. Uses: Cb181963 may play a role in the treatment of staphylococcal infections, including those caused by mrsa and in the prophylaxis of biofilm-associated mssa and mrsa infections. Synonyms: CB 181963; CB-181963; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7- ( ( (2Z) - (5-amino-1, 2, 4-thiadiazol-3-yl) ( (fluoromethoxy) imino) acetyl) amino) -3- ( (E) - ( (imino-1-piperazinylmethyl) methylhydrazono) methyl) -8-oxo-, (6R,7R)-. Grades: 98%. CAS No. 635292-67-0. Molecular formula: C19H24FN11O5S2. Mole weight: 569.59. | |
| CB 1837 | CB 1837 was the parent member of a series of nitrophenyl aziridines evaluated for antitumour activity by Khan and Ross. Synonyms: 1-(2,4-dinitrophenyl)aziridine; CB 1837; CB1837; CB-1837; AI3-51871; NSC 3375. Grades: 95%. CAS No. 27141-65-7. Molecular formula: C8H7N3O4. Mole weight: 209.159. | |
| CB 1954 | solid. Group: Fluorescence/luminescence spectroscopy. |  |
| CB1 agonist 1 | CB1 agonist 1 (compound 22) is an agonist of CB1. CB1 agonist 1 shows affinity to CB1 receptor with an pIC 50 value of 5.7. CB1 agonist 1 can be used for the research of brain disorders [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 851212-80-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148137. | |
| CB1 antagonist 4 | CB1 antagonist 4 (compound 8) is a peripheral selective cannabinoid receptor type 1 (CB1) receptor antagonist. CB1 antagonist 4 shows limited penetrance to the brain in order to minimize or prevent CNS adverse reactions, and preserves potential antiobesity effects. CB1 antagonist 4 reduces propensity for psychiatric side effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1253641-65-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112340. | |
| CB1 Antagonist AM251 (N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide, AM 251) | A potent and highly selective antagonist for cannabinoid subtyre 1 (CB1) receptor. Affinity for CB1 (IC50 = 8nM, Ki = 7.49nM) is more than 306-fold higher than that for CB2 receptors. Has been used in a study to determine its interaction with hippocampal neurons to enhance spatial memory in mice. Group: Biochemicals. Grades: Highly Purified. CAS No. 183232-66-8. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| CB1-IN-1 | CB1-IN-1 is an antagonist of cannabinoid receptor type 1 (CB1R) located in the peripheral nervous system, which may be significant for pain modulation. Synonyms: DBPR211; DBPR 211; DBPR-211; CB1-IN-1; CB1-IN 1; CB1-IN1; 1- (2, 4-dichlorophenyl) -N-piperidin-1-yl-4-[ (pyrrolidin-1-ylsulfonylamino) methyl]-5-[5-[2-[4- (trifluoromethyl) phenyl]ethynyl]thiophen-2-yl]pyrazole-3-carboxamideCB1-IN-1SCHEMBL14816497CS-5144; HY-12790; CS 5144; HY 12790; CS5144; HY12790N-Piperidino-1-(2,4-dichlorophenyl)-4-(pyrrolizinosu. CAS No. 1429239-98-4. Molecular formula: C33H31Cl2F3N6O3S2. Mole weight: 751.67. | |
| CB1R antagonist 1 | CB1R Allosteric modulator 5, a selective cannabinoid-1 receptor (CB1R) inverse agonist with an IC 50 value of 4.2 μM and EC 50 value of ?10 μM. CB1R Allosteric modulator 5 can be used for the research of metabolic and obesity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 334668-69-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-150067. | |
| CB-25 | Δ9-Tetrahydrocannabinol (THC) is the primary psychoactive constituent of cannabis and an active cannabinoid pharmacotherapy component. Anandamide (AEA), also known as N-arachidonoylethanolamine, is an endogenous lipid with cannabinergic activity. CB-25 is a stable analog of Δ9-tetrahydrocannabinol (THC) and anandamide (AEA). It exhibits high affinity for the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors with Ki values of 5.2 and 13 nM, respectively. Synonyms: CB25; CB 25. Grades: ≥98%. CAS No. 869376-63-6. Molecular formula: C25H41NO3. Mole weight: 403.6. | |
| CB-25 | CB-25 is a ligand of CB1 cannabinoid receptors , acting as a partial agonist. CB-25 enhances Forskolin (HY-15371)-induced cAMP formation in cancer cells but not hCB1-CHO cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 869376-63-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121541. | |
| CB-25-I | CB-25-I, a water-soluble dipeptide, is produced by the strain of Serratia plymuthica. It has an inhibitory effect on individual Candida bacteria (Condida albicans M-9, C. guilliermondii IFO 0454). Synonyms: N-(R,R)-3-epoxysuccinamoyl-(S)-2,3-diaminopropanoyl-L-valine; Nbeta-(R,R)-epoxysuccinamoyl-(S)-2,3-diaminopropanoyl-L-valine. Molecular formula: C12H20N4O6. Mole weight: 316.31. | |
| CB2 Agonist, JWH 015 ((2-Methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone, JWH-015, JWH 015) | A potent and highly selective agonist for cannabinoid subtye 2 (CB2) receptor. Affinity for CB2 (Ki = 13.8nM) is more than 28-fold higher than that for CB1 (Ki = 383nM) receptors. Group: Biochemicals. Grades: Highly Purified. CAS No. 155471-08-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| CB2 Inverse Agonist, SR 144528 (5- (4- chloro- 3- methylphenyl)- 1- [(4- methylphenyl)methyl]- N- [(1S, 2S, 4R)- 1, 3, 3- trimethylbicyclo[2. 2. 1]hept- 2- yl]- 1H- pyrazole-3) | A selective inverse agonist for peripheral cannabinoid (CB2) receptors (Ki = 0.6nM and 400nM for CB2 and CB1 receptors, respectively). Has been used in studies related to control of pain initiation, suppression of inflammation, and immune activation. Group: Biochemicals. Grades: Highly Purified. CAS No. 192703-06-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| CB2 receptor agonist 10 | CB2 receptor agonist 10 is a CB2 receptor agonist with a K i of 3.7 nM for hCB2 , a K i of 110 nM for hCB1 , and an EC 50 of 0.52 nM for hCB2 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1046140-32-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-113591. | |
| CB2 receptor agonist 2 | CB2 receptor agonist 2 is a potent and selective agonist for the CB2 (cannabinoid type 2) receptor with a K i of 8.5 nM. CB2 receptor agonist 2 has high affinity and selectivity for CB2 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1314230-75-5. Pack Sizes: 5 mg. Product ID: HY-132217. | |
| CB 300919 | CB 300919 is a water-soluble analogue of CB30865; has a continuous exposure (96 h) growth inhibition IC50 value of 2 nM in human CH1 ovarian tumor xenograft. Synonyms: CB-300919; CB300919; CB 300919; UNII-55I8ETE76Y. Grades: >98%. CAS No. 289715-28-2. Molecular formula: C32H34ClN7O2. Mole weight: 584.11. | |
| CB30865 | CB30865 is a highly potent cytotoxic agent. The compound inhibits isolated mammalian thymidylate synthase (TS), but this inhibition is insufficient to account for its cellular toxicity. Thymidylate synthase (TS) is a critical enzyme in the de novo synthesis of thymidylate (dTTP) and has long been recognized as a target for chemotherapeutic intervention. Synonyms: CB-30865; CB 30865; CB30865; ZM 242421; ZM242421; ZM-242421. Grades: >98%. CAS No. 206275-15-2. Molecular formula: C26H22BrN5O2. Mole weight: 516.39. | |
| CB30900 | CB30900 has been found to be a thymidylate synthase inhibitor that could have some extent of activity in models with low or defective folylpolyglutamate synthetase. Synonyms: CB 30900; CB30900; CB-30900; N-(N-(4-(N-((3,4-Dihydro-2,7-dimethyl-4-oxo-6-quinazolinyl)methyl)-N-prop-2-ynylamino)-2-fluorobenzoyl)-L-gamma-glutamyl)-D-glutamic acid. Grades: 98%. CAS No. 145788-82-5. Molecular formula: C31H32FN5O9. Mole weight: 637.61. | |
| CB 3703 | CB 3703 is an inhibitor of hydrofolate reductase. Uses: An inhibitor of hydrofolate reductase. Synonyms: CB 3703; CB3703; CB-3703; NSC 289522. N-(p-(((2,4-Diamino-5-methyl-6-quinazolinyl)methyl)amino)benzoyl)-L-glutamic acid;L-Glutamic acid, N-(4-(((2,4-diamino-5-methyl-6-quinazolinyl)methyl)amino)benzoyl)-. Grades: ≥95%. CAS No. 32093-09-7. Molecular formula: C22H24N6O5. Mole weight: 452.18. | |
| CB-3705 | CB-3705 is a bio-active chemical compound. Synonyms: CB 3705; CB3705; 5,8-Dideazafolic acid; 2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid. Grades: 98%. CAS No. 5854-11-5. Molecular formula: C21H21N5O6. Mole weight: 439.42. | |
| CB 3731 | CB 3731 can be used in fluorine-19 nuclear magnetic resonance studies of binary and ternary complexes of thymidylate synthase. Synonyms: CB 3731; CB-3731; CB3731. N-(4-((N-(2-Amino-4-hydroxy-6-quinazolinyl)methyl)-N-(fluoroethyl)amino)benzoyl)glutamic acid. Grades: 98%. CAS No. 80015-07-2. Molecular formula: C23H24FN5O6. Mole weight: 458.47. | |
| CB-3988 | CB 3988 is a bio-active chemical compound. Synonyms: CB 3988; CB-3988; CB3988. (2S)-2-[2-Trifluoromethyl-4-[N-[(3,4-dihydro-2-methyl-4-oxoquinazolin)-6-ylmethyl]-N-(2-propynyl)amino]benzoylamino]glutaric acid;N-[2-Trifluoromethyl-4-[2-propynyl[(3,4-dihydro-4-oxo-2-methylquinazolin)-6-ylmethyl]amino]benzoyl]-L-glutamic acid; (2S) -2-[[4-[ (2-methyl-4-oxo-1H-quinazolin-6-yl) methyl-prop-2-ynylamino]-2- (trifluoromethyl) benzoyl]amino]pentanedioic acid. Grades: >98%. CAS No. 112888-26-3. Molecular formula: C26H23F3N4O6. Mole weight: 544.48. | |
| CB-403 | CB-403, a cinnamaldehyde derivative, which has antitumor effect through the arrest of cell cycle progression in the G2/M phase. Uses: Antitumor effect through the arrest of cell cycle progression in the g2/m phase. Synonyms: CB-403; CB403; CB 403; UNII-4V9Q0C88UK. 2-Propenal, 3-[2-[(2-methylphenyl)?methoxy]?phenyl]?-, (2E)?-. Grades: ≥96%. CAS No. 302356-18-9. Molecular formula: C17H16O2. Mole weight: 252.11. | |
| CB5083 | CB-5083 is a novel first in class, potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models. CB-5083 causes rapid and sustained accumulation of poly-ubiquitin in tumor xenografts after a single administration. CB-5083 showed activity to inhibit tumor growth in multiple rodent models of human cancer. Furthermore, CB-5083 appears to exhibit greater potency over current proteasome inhibitors that further validate targeting p97 and protein homeostasis in the treatment of cancer. Synonyms: CB5083; CB-5083; CB 5083. Grades: >98%. CAS No. 1542705-92-9. Molecular formula: C24H23N5O2. Mole weight: 413.4. | |
| CB-5083 | CB-5083 is a first-in-class, potent, selective, and orally bioavailable inhibitor of the p97 AAA ATPase / VCP. CB-5083 selectively inhibits p97 through its D2 site with the IC 50 of 11 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1542705-92-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12861. | |
| CB-52 | Δ9-Tetrahydrocannabinol (THC) is the primary psychoactive constituent of cannabis and an active cannabinoid pharmacotherapy component. Anandamide (AEA), also known as N-arachidonoylethanolamine, is an endogenous lipid with cannabinergic activity. CB-52 is a stable analog of Δ9-tetrahydrocannabinol (THC) and anandamide (AEA). It exhibits high affinity for the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors with Ki values of 210 and 30 nM, respectively. Synonyms: CB52;CB 52. Grades: ≥98%. CAS No. 869376-90-9. Molecular formula: C26H43NO3. Mole weight: 417.6. | |
| CB-5339 | CB-5339 is an oral activity potent p97 inhibitor with an IC 50 <30 nM. CB-5339 can be used for leukemia research [1]. CB-5339 extracted from WO2015109285A1 compound FF07. Uses: Scientific research. Group: Signaling pathways. CAS No. 1863952-15-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128724. | |
| CB 65 | CB 65 is a high affinity and selective CB2 receptor agonist with Ki of 3.3 nM for CB2 receptor and Ki of > 1000 nM for CB1 receptor. Uses: Cannabinoid receptor agonists. Synonyms: N-Cyclohexyl-7-chloro-1-[2-(4-morpholinyl)ethyl]quinolin-4(1H)-one-3-carboxamide. Grades: ≥99%. CAS No. 913534-05-1. Molecular formula: C22H28ClN3O3. Mole weight: 417.93. | |
| CB-6644 | CB-6644 is a novel allosteric selective inhibitor of the ruvbl1/2 complex with anti-cancer activity. CB-6644 blocks the ATPase activity of RUVBL1/2 with an IC50 of 15 nM. CB-6644 interacts specifically with RUVBL1/2 in cancer cells, leading to cell death. Importantly, drug-acquired-resistant cell clones have amino acid mutations in either RUVBL1 or RUVBL2, suggesting that cell killing is an on-target consequence of RUVBL1/2 engagement. In xenograft models of acute myeloid leukemia and multiple myeloma, CB-6644 significantly reduced tumor growth without obvious toxicity. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CB-6644; CB 6644; CB6644. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2316817-88-4. Molecular formula: C29H34ClFN4O5. Mole weight: 573.06. Purity: >96%. IUPACName: 5-Chloro-2-ethoxy-4-fluoro-N-(4-((3-(methoxymethyl)-1-oxo-6,7-dihydro-1H,5H-benzo[c]pyrazolo[1,2-a][1,2]diazepin-2-yl)amino)-2,2-dimethyl-4-oxobutyl)benzamide. Canonical SMILES: O=C(NCC(C)(C)CC(NC(C1=O)=C(COC)N2N1C3=CC=CC=C3CCC2)=O)C4=CC(Cl)=C(F)C=C4OCC. Product ID: ACM2316817884. Alfa Chemistry ISO 9001:2015 Certified. | |
| CB7646 | CB7646 is a stable analogue of trimelamol (TM). It is used as an anti-tumour agent. Uses: Cb7646 is used as an anti-tumour agent. Synonyms: CB-7646; CB 7646; CB7646; UNII-LYO93N5MEB. Methanol, ((6-(methylamino)-1,3,5-triazine-2,4-diyl)bis(methylimino))bis-;[[4-[Hydroxymethyl(methyl)amino]-6-(methylamino)-1,3,5-triazin-2-yl]-methylamino]methanol. Grades: >98 %. CAS No. 104880-54-8. Molecular formula: C8H16N6O2. Mole weight: 228.25. | |
| CB-7921220 | CB-7921220 is an adenylate cyclase inhibitor which is selective, reducing adenylyl cyclase type I and VI activity by 60% while having no effect on types II and V in Sf9 membranes stimulated by forskolin at a concentration of 100 μM. CB-7921220 has a binding conformation similar to ATP and P-site inhibitors, which may explain its lack of selectivity between AC1 and AC6. Synonyms: CB7921220; CB 7921220; CB-7921220; 6-[(E)-2-(4-aminophenyl)ethenyl]pyridine-2-carboxylic acid. CAS No. 115453-99-1. Molecular formula: C14H12N2O2. Mole weight: 240.26. | |
| CB-839 | CB-839 an is orally bioavailable inhibitor of glutaminase, with potential antineoplastic activity. Upon oral administration, CB-839 selectively and irreversibly inhibits glutaminase, a mitochondrial enzyme that is essential for the conversion of the amino acid glutamine into glutamate. By blocking glutamine utilization, proliferation in rapidly growing cells is impaired. Glutamine-dependent tumors rely on the conversion of exogenous glutamine into glutamate and glutamate metabolites to both provide energy and generate building blocks for the production of macromolecules, which are needed for cellular growth and survival. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). ( ). Synonyms: CB-839; CB839; CB 839. Grades: 98%. CAS No. 1439399-58-2. Molecular formula: C26H24F3N7O3S. Mole weight: 571.57. | |
| CB-86 | Cannabinoid receptors (CB) are of a class of cell membrane receptors in the G protein-coupled receptor superfamily. CB-86 is a resorcinol-anandamide hybrid compound that acts as a partial agonist for the CB1 receptor with Ki of 5.6 nM and a neutral antagonist for CB2 receptor with Ki of 7.9 nM. CB-86 exhibits antinociceptive effects in mice treated with formalin. Synonyms: CB86; CB 86. Grades: ≥98%. CAS No. 1150586-64-3. Molecular formula: C26H43NO3. Mole weight: 417.6. | |
| CB 966 | CB 966 is a novel analogues of 1,25-dihydroxyvitamin D3 and it was found to significantly delay the rejection of allogeneic skin grafts in CBA (H-2k) recipient mice. Synonyms: CB 966; CB966; CB-966. (1R-(1alpha(R*), 3abeta, 4E(1R*, 3S*, 5Z), 7aalpha))-5-((1-(6-ethyl-6-hydroxy-1-methyloctyl)octahydro-7a-methyl-4H-inden-4-ylidene)ethylidene)-4-methylene-1, 3-Cyclohexanediol. Grades: 98%. CAS No. 128312-71-0. Molecular formula: C30H50O3. Mole weight: 458.72. | |
| CBA | Transient Receptor Potential Cation Channel Subfamily M Member 4 (TRPM 4) is a Protein Coding gene. Diseases associated with TRPM4 include Progressive Familial Heart Block, Type Ib and Erythrokeratodermia Variabilis Et Progressiva. TRPM4-IN-5 is a potent and selective inhibitor of the cation channel TRPM4 blocker with IC 50 of 1.5 μM. Synonyms: 4-Chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid; TRPM4-IN-5; TRPM4IN-5; TRPM4-IN5; TRPM4 IN-5. Grades: ≥98%. CAS No. 351424-20-9. Molecular formula: C15H11Cl2NO4. Mole weight: 340.16. | |
| CBB1003 | CBB1003, a piperazine derivative, has been found to be a histone demethylase LSD1 inhibitor that could restrain the proliferation and colony formation of CRC cell in mice. IC50: 10.54 uM. Uses: Cbb1003 has been found to be a histone demethylase lsd1 inhibitor that could restrain the proliferation and colony formation of crc cell in mice. Synonyms: CBB1003; SCHEMBL16273292; CS-3476. Grades: 98%. CAS No. 1379573-88-2. Molecular formula: C25H31N9O4. Mole weight: 521.57. | |
| CBB1007 | CBB1007, an amidino-guanidinium derivative, has been found to have biological activity in anticancer-study by acting as a LSD1 inhibitor. IC50: 5.27 uM. Uses: Cbb1007 has been found to have biological activity in anticancer-study by acting as a lsd1 inhibitor. Synonyms: CBB1007; SCHEMBL16273312; CS-1737. Grades: 98%. CAS No. 1379573-92-8. Molecular formula: C27H34N8O4. Mole weight: 534.61. | |
Our database is helping our users find suppliers everyday.
