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| Product | Description | |
|---|---|---|
| CB181963 | CB181963 shows excellent activity against MRSA strains resistant to other cephalosporins in both planktonic and biofilm cultures. It is a potent antistaphylococcal agent with better activity against MRSA. It may play a role in the treatment of staphylococcal infections, including those caused by MRSA and in the prophylaxis of biofilm-associated MSSA and MRSA infections. Uses: Cb181963 may play a role in the treatment of staphylococcal infections, including those caused by mrsa and in the prophylaxis of biofilm-associated mssa and mrsa infections. Synonyms: CB 181963; CB-181963; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7- ( ( (2Z) - (5-amino-1, 2, 4-thiadiazol-3-yl) ( (fluoromethoxy) imino) acetyl) amino) -3- ( (E) - ( (imino-1-piperazinylmethyl) methylhydrazono) methyl) -8-oxo-, (6R,7R)-. Grades: 98%. CAS No. 635292-67-0. Molecular formula: C19H24FN11O5S2. Mole weight: 569.59. |  |
| CB 1837 | CB 1837 was the parent member of a series of nitrophenyl aziridines evaluated for antitumour activity by Khan and Ross. Synonyms: 1-(2,4-dinitrophenyl)aziridine; CB 1837; CB1837; CB-1837; AI3-51871; NSC 3375. Grades: 95%. CAS No. 27141-65-7. Molecular formula: C8H7N3O4. Mole weight: 209.159. | |
| CB 1954 | solid. Group: Fluorescence/luminescence spectroscopy. |  |
| CB1 agonist 1 | CB1 agonist 1 (compound 22) is an agonist of CB1. CB1 agonist 1 shows affinity to CB1 receptor with an pIC 50 value of 5.7. CB1 agonist 1 can be used for the research of brain disorders [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 851212-80-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148137. |  |
| CB1 antagonist 4 | CB1 antagonist 4 (compound 8) is a peripheral selective cannabinoid receptor type 1 (CB1) receptor antagonist. CB1 antagonist 4 shows limited penetrance to the brain in order to minimize or prevent CNS adverse reactions, and preserves potential antiobesity effects. CB1 antagonist 4 reduces propensity for psychiatric side effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1253641-65-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112340. | |
| CB1 Antagonist AM251 (N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide, AM 251) | A potent and highly selective antagonist for cannabinoid subtyre 1 (CB1) receptor. Affinity for CB1 (IC50 = 8nM, Ki = 7.49nM) is more than 306-fold higher than that for CB2 receptors. Has been used in a study to determine its interaction with hippocampal neurons to enhance spatial memory in mice. Group: Biochemicals. Grades: Highly Purified. CAS No. 183232-66-8. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| CB1-IN-1 | CB1-IN-1 is an antagonist of cannabinoid receptor type 1 (CB1R) located in the peripheral nervous system, which may be significant for pain modulation. Synonyms: DBPR211; DBPR 211; DBPR-211; CB1-IN-1; CB1-IN 1; CB1-IN1; 1- (2, 4-dichlorophenyl) -N-piperidin-1-yl-4-[ (pyrrolidin-1-ylsulfonylamino) methyl]-5-[5-[2-[4- (trifluoromethyl) phenyl]ethynyl]thiophen-2-yl]pyrazole-3-carboxamideCB1-IN-1SCHEMBL14816497CS-5144; HY-12790; CS 5144; HY 12790; CS5144; HY12790N-Piperidino-1-(2,4-dichlorophenyl)-4-(pyrrolizinosu. CAS No. 1429239-98-4. Molecular formula: C33H31Cl2F3N6O3S2. Mole weight: 751.67. | |
| CB1R antagonist 1 | CB1R Allosteric modulator 5, a selective cannabinoid-1 receptor (CB1R) inverse agonist with an IC 50 value of 4.2 μM and EC 50 value of ?10 μM. CB1R Allosteric modulator 5 can be used for the research of metabolic and obesity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 334668-69-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-150067. | |
| CB-25 | CB-25 is a ligand of CB1 cannabinoid receptors , acting as a partial agonist. CB-25 enhances Forskolin (HY-15371)-induced cAMP formation in cancer cells but not hCB1-CHO cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 869376-63-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121541. | |
| CB-25 | Δ9-Tetrahydrocannabinol (THC) is the primary psychoactive constituent of cannabis and an active cannabinoid pharmacotherapy component. Anandamide (AEA), also known as N-arachidonoylethanolamine, is an endogenous lipid with cannabinergic activity. CB-25 is a stable analog of Δ9-tetrahydrocannabinol (THC) and anandamide (AEA). It exhibits high affinity for the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors with Ki values of 5.2 and 13 nM, respectively. Synonyms: CB25; CB 25. Grades: ≥98%. CAS No. 869376-63-6. Molecular formula: C25H41NO3. Mole weight: 403.6. | |
| CB-25-I | CB-25-I, a water-soluble dipeptide, is produced by the strain of Serratia plymuthica. It has an inhibitory effect on individual Candida bacteria (Condida albicans M-9, C. guilliermondii IFO 0454). Synonyms: N-(R,R)-3-epoxysuccinamoyl-(S)-2,3-diaminopropanoyl-L-valine; Nbeta-(R,R)-epoxysuccinamoyl-(S)-2,3-diaminopropanoyl-L-valine. Molecular formula: C12H20N4O6. Mole weight: 316.31. | |
| CB2 Agonist, JWH 015 ((2-Methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone, JWH-015, JWH 015) | A potent and highly selective agonist for cannabinoid subtye 2 (CB2) receptor. Affinity for CB2 (Ki = 13.8nM) is more than 28-fold higher than that for CB1 (Ki = 383nM) receptors. Group: Biochemicals. Grades: Highly Purified. CAS No. 155471-08-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| CB2 Inverse Agonist, SR 144528 (5- (4- chloro- 3- methylphenyl)- 1- [(4- methylphenyl)methyl]- N- [(1S, 2S, 4R)- 1, 3, 3- trimethylbicyclo[2. 2. 1]hept- 2- yl]- 1H- pyrazole-3) | A selective inverse agonist for peripheral cannabinoid (CB2) receptors (Ki = 0.6nM and 400nM for CB2 and CB1 receptors, respectively). Has been used in studies related to control of pain initiation, suppression of inflammation, and immune activation. Group: Biochemicals. Grades: Highly Purified. CAS No. 192703-06-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| CB2 receptor agonist 10 | CB2 receptor agonist 10 is a CB2 receptor agonist with a K i of 3.7 nM for hCB2 , a K i of 110 nM for hCB1 , and an EC 50 of 0.52 nM for hCB2 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1046140-32-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-113591. | |
| CB2 receptor agonist 2 | CB2 receptor agonist 2 is a potent and selective agonist for the CB2 (cannabinoid type 2) receptor with a K i of 8.5 nM. CB2 receptor agonist 2 has high affinity and selectivity for CB2 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1314230-75-5. Pack Sizes: 5 mg. Product ID: HY-132217. | |
| CB 300919 | CB 300919 is a water-soluble analogue of CB30865; has a continuous exposure (96 h) growth inhibition IC50 value of 2 nM in human CH1 ovarian tumor xenograft. Synonyms: CB-300919; CB300919; CB 300919; UNII-55I8ETE76Y. Grades: >98%. CAS No. 289715-28-2. Molecular formula: C32H34ClN7O2. Mole weight: 584.11. | |
| CB30865 | CB30865 is a highly potent cytotoxic agent. The compound inhibits isolated mammalian thymidylate synthase (TS), but this inhibition is insufficient to account for its cellular toxicity. Thymidylate synthase (TS) is a critical enzyme in the de novo synthesis of thymidylate (dTTP) and has long been recognized as a target for chemotherapeutic intervention. Synonyms: CB-30865; CB 30865; CB30865; ZM 242421; ZM242421; ZM-242421. Grades: >98%. CAS No. 206275-15-2. Molecular formula: C26H22BrN5O2. Mole weight: 516.39. | |
| CB30900 | CB30900 has been found to be a thymidylate synthase inhibitor that could have some extent of activity in models with low or defective folylpolyglutamate synthetase. Synonyms: CB 30900; CB30900; CB-30900; N-(N-(4-(N-((3,4-Dihydro-2,7-dimethyl-4-oxo-6-quinazolinyl)methyl)-N-prop-2-ynylamino)-2-fluorobenzoyl)-L-gamma-glutamyl)-D-glutamic acid. Grades: 98%. CAS No. 145788-82-5. Molecular formula: C31H32FN5O9. Mole weight: 637.61. | |
| CB 3703 | CB 3703 is an inhibitor of hydrofolate reductase. Uses: An inhibitor of hydrofolate reductase. Synonyms: CB 3703; CB3703; CB-3703; NSC 289522. N-(p-(((2,4-Diamino-5-methyl-6-quinazolinyl)methyl)amino)benzoyl)-L-glutamic acid;L-Glutamic acid, N-(4-(((2,4-diamino-5-methyl-6-quinazolinyl)methyl)amino)benzoyl)-. Grades: ≥95%. CAS No. 32093-09-7. Molecular formula: C22H24N6O5. Mole weight: 452.18. | |
| CB-3705 | CB-3705 is a bio-active chemical compound. Synonyms: CB 3705; CB3705; 5,8-Dideazafolic acid; 2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid. Grades: 98%. CAS No. 5854-11-5. Molecular formula: C21H21N5O6. Mole weight: 439.42. | |
| CB 3731 | CB 3731 can be used in fluorine-19 nuclear magnetic resonance studies of binary and ternary complexes of thymidylate synthase. Synonyms: CB 3731; CB-3731; CB3731. N-(4-((N-(2-Amino-4-hydroxy-6-quinazolinyl)methyl)-N-(fluoroethyl)amino)benzoyl)glutamic acid. Grades: 98%. CAS No. 80015-07-2. Molecular formula: C23H24FN5O6. Mole weight: 458.47. | |
| CB-3988 | CB 3988 is a bio-active chemical compound. Synonyms: CB 3988; CB-3988; CB3988. (2S)-2-[2-Trifluoromethyl-4-[N-[(3,4-dihydro-2-methyl-4-oxoquinazolin)-6-ylmethyl]-N-(2-propynyl)amino]benzoylamino]glutaric acid;N-[2-Trifluoromethyl-4-[2-propynyl[(3,4-dihydro-4-oxo-2-methylquinazolin)-6-ylmethyl]amino]benzoyl]-L-glutamic acid; (2S) -2-[[4-[ (2-methyl-4-oxo-1H-quinazolin-6-yl) methyl-prop-2-ynylamino]-2- (trifluoromethyl) benzoyl]amino]pentanedioic acid. Grades: >98%. CAS No. 112888-26-3. Molecular formula: C26H23F3N4O6. Mole weight: 544.48. | |
| CB-403 | CB-403, a cinnamaldehyde derivative, which has antitumor effect through the arrest of cell cycle progression in the G2/M phase. Uses: Antitumor effect through the arrest of cell cycle progression in the g2/m phase. Synonyms: CB-403; CB403; CB 403; UNII-4V9Q0C88UK. 2-Propenal, 3-[2-[(2-methylphenyl)?methoxy]?phenyl]?-, (2E)?-. Grades: ≥96%. CAS No. 302356-18-9. Molecular formula: C17H16O2. Mole weight: 252.11. | |
| CB5083 | CB-5083 is a novel first in class, potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models. CB-5083 causes rapid and sustained accumulation of poly-ubiquitin in tumor xenografts after a single administration. CB-5083 showed activity to inhibit tumor growth in multiple rodent models of human cancer. Furthermore, CB-5083 appears to exhibit greater potency over current proteasome inhibitors that further validate targeting p97 and protein homeostasis in the treatment of cancer. Synonyms: CB5083; CB-5083; CB 5083. Grades: >98%. CAS No. 1542705-92-9. Molecular formula: C24H23N5O2. Mole weight: 413.4. | |
| CB-5083 | CB-5083 is a first-in-class, potent, selective, and orally bioavailable inhibitor of the p97 AAA ATPase / VCP. CB-5083 selectively inhibits p97 through its D2 site with the IC 50 of 11 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1542705-92-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12861. | |
| CB-52 | Δ9-Tetrahydrocannabinol (THC) is the primary psychoactive constituent of cannabis and an active cannabinoid pharmacotherapy component. Anandamide (AEA), also known as N-arachidonoylethanolamine, is an endogenous lipid with cannabinergic activity. CB-52 is a stable analog of Δ9-tetrahydrocannabinol (THC) and anandamide (AEA). It exhibits high affinity for the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors with Ki values of 210 and 30 nM, respectively. Synonyms: CB52;CB 52. Grades: ≥98%. CAS No. 869376-90-9. Molecular formula: C26H43NO3. Mole weight: 417.6. | |
| CB-5339 | CB-5339 is an oral activity potent p97 inhibitor with an IC 50 <30 nM. CB-5339 can be used for leukemia research [1]. CB-5339 extracted from WO2015109285A1 compound FF07. Uses: Scientific research. Group: Signaling pathways. CAS No. 1863952-15-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128724. | |
| CB 65 | CB 65 is a high affinity and selective CB2 receptor agonist with Ki of 3.3 nM for CB2 receptor and Ki of > 1000 nM for CB1 receptor. Uses: Cannabinoid receptor agonists. Synonyms: N-Cyclohexyl-7-chloro-1-[2-(4-morpholinyl)ethyl]quinolin-4(1H)-one-3-carboxamide. Grades: ≥99%. CAS No. 913534-05-1. Molecular formula: C22H28ClN3O3. Mole weight: 417.93. | |
| CB-6644 | CB-6644 is a selective inhibitor of RUVBL1/2 complex with anti-cancer activity. CB-6644 blocks the ATPase activity of RUVBL1/2 with an IC50 of 15 nM[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2316817-88-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg. Product ID: HY-114429. | |
| CB-6644 | CB-6644 is a novel allosteric selective inhibitor of the ruvbl1/2 complex with anti-cancer activity. CB-6644 blocks the ATPase activity of RUVBL1/2 with an IC50 of 15 nM. CB-6644 interacts specifically with RUVBL1/2 in cancer cells, leading to cell death. Importantly, drug-acquired-resistant cell clones have amino acid mutations in either RUVBL1 or RUVBL2, suggesting that cell killing is an on-target consequence of RUVBL1/2 engagement. In xenograft models of acute myeloid leukemia and multiple myeloma, CB-6644 significantly reduced tumor growth without obvious toxicity. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CB-6644; CB 6644; CB6644. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2316817-88-4. Molecular formula: C29H34ClFN4O5. Mole weight: 573.06. Purity: >96%. IUPACName: 5-Chloro-2-ethoxy-4-fluoro-N-(4-((3-(methoxymethyl)-1-oxo-6,7-dihydro-1H,5H-benzo[c]pyrazolo[1,2-a][1,2]diazepin-2-yl)amino)-2,2-dimethyl-4-oxobutyl)benzamide. Canonical SMILES: O=C(NCC(C)(C)CC(NC(C1=O)=C(COC)N2N1C3=CC=CC=C3CCC2)=O)C4=CC(Cl)=C(F)C=C4OCC. Product ID: ACM2316817884. Alfa Chemistry ISO 9001:2015 Certified. |  |
| CB7646 | CB7646 is a stable analogue of trimelamol (TM). It is used as an anti-tumour agent. Uses: Cb7646 is used as an anti-tumour agent. Synonyms: CB-7646; CB 7646; CB7646; UNII-LYO93N5MEB. Methanol, ((6-(methylamino)-1,3,5-triazine-2,4-diyl)bis(methylimino))bis-;[[4-[Hydroxymethyl(methyl)amino]-6-(methylamino)-1,3,5-triazin-2-yl]-methylamino]methanol. Grades: >98 %. CAS No. 104880-54-8. Molecular formula: C8H16N6O2. Mole weight: 228.25. | |
| CB-7921220 | CB-7921220 is an adenylate cyclase inhibitor which is selective, reducing adenylyl cyclase type I and VI activity by 60% while having no effect on types II and V in Sf9 membranes stimulated by forskolin at a concentration of 100 μM. CB-7921220 has a binding conformation similar to ATP and P-site inhibitors, which may explain its lack of selectivity between AC1 and AC6. Synonyms: CB7921220; CB 7921220; CB-7921220; 6-[(E)-2-(4-aminophenyl)ethenyl]pyridine-2-carboxylic acid. CAS No. 115453-99-1. Molecular formula: C14H12N2O2. Mole weight: 240.26. | |
| CB-839 | CB-839 an is orally bioavailable inhibitor of glutaminase, with potential antineoplastic activity. Upon oral administration, CB-839 selectively and irreversibly inhibits glutaminase, a mitochondrial enzyme that is essential for the conversion of the amino acid glutamine into glutamate. By blocking glutamine utilization, proliferation in rapidly growing cells is impaired. Glutamine-dependent tumors rely on the conversion of exogenous glutamine into glutamate and glutamate metabolites to both provide energy and generate building blocks for the production of macromolecules, which are needed for cellular growth and survival. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). ( ). Synonyms: CB-839; CB839; CB 839. Grades: 98%. CAS No. 1439399-58-2. Molecular formula: C26H24F3N7O3S. Mole weight: 571.57. | |
| CB-86 | Cannabinoid receptors (CB) are of a class of cell membrane receptors in the G protein-coupled receptor superfamily. CB-86 is a resorcinol-anandamide hybrid compound that acts as a partial agonist for the CB1 receptor with Ki of 5.6 nM and a neutral antagonist for CB2 receptor with Ki of 7.9 nM. CB-86 exhibits antinociceptive effects in mice treated with formalin. Synonyms: CB86; CB 86. Grades: ≥98%. CAS No. 1150586-64-3. Molecular formula: C26H43NO3. Mole weight: 417.6. | |
| CB 966 | CB 966 is a novel analogues of 1,25-dihydroxyvitamin D3 and it was found to significantly delay the rejection of allogeneic skin grafts in CBA (H-2k) recipient mice. Synonyms: CB 966; CB966; CB-966. (1R-(1alpha(R*), 3abeta, 4E(1R*, 3S*, 5Z), 7aalpha))-5-((1-(6-ethyl-6-hydroxy-1-methyloctyl)octahydro-7a-methyl-4H-inden-4-ylidene)ethylidene)-4-methylene-1, 3-Cyclohexanediol. Grades: 98%. CAS No. 128312-71-0. Molecular formula: C30H50O3. Mole weight: 458.72. | |
| CBA | Transient Receptor Potential Cation Channel Subfamily M Member 4 (TRPM 4) is a Protein Coding gene. Diseases associated with TRPM4 include Progressive Familial Heart Block, Type Ib and Erythrokeratodermia Variabilis Et Progressiva. TRPM4-IN-5 is a potent and selective inhibitor of the cation channel TRPM4 blocker with IC 50 of 1.5 μM. Synonyms: 4-Chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid; TRPM4-IN-5; TRPM4IN-5; TRPM4-IN5; TRPM4 IN-5. Grades: ≥98%. CAS No. 351424-20-9. Molecular formula: C15H11Cl2NO4. Mole weight: 340.16. | |
| CBB1003 | CBB1003, a piperazine derivative, has been found to be a histone demethylase LSD1 inhibitor that could restrain the proliferation and colony formation of CRC cell in mice. IC50: 10.54 uM. Uses: Cbb1003 has been found to be a histone demethylase lsd1 inhibitor that could restrain the proliferation and colony formation of crc cell in mice. Synonyms: CBB1003; SCHEMBL16273292; CS-3476. Grades: 98%. CAS No. 1379573-88-2. Molecular formula: C25H31N9O4. Mole weight: 521.57. | |
| CBB1007 | CBB1007, an amidino-guanidinium derivative, has been found to have biological activity in anticancer-study by acting as a LSD1 inhibitor. IC50: 5.27 uM. Uses: Cbb1007 has been found to have biological activity in anticancer-study by acting as a lsd1 inhibitor. Synonyms: CBB1007; SCHEMBL16273312; CS-1737. Grades: 98%. CAS No. 1379573-92-8. Molecular formula: C27H34N8O4. Mole weight: 534.61. | |
| CbBPCb | CbBPCb. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3,3'-Di(9H-pyrido[2,3-b]-indol-9-yl)biphenyl. Product Category: Organic Light Emitting Diode (OLED). CAS No. 1469997-91-8. Molecular formula: C34H22N4. Mole weight: 486.57 g/mol. Product ID: ACM1469997918. Alfa Chemistry ISO 9001:2015 Certified. | |
| CBBPE | CBBPE. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9,9'-(Oxybis([1,1'-biphenyl]-4',3-diyl))bis(9H-carbazole). Product Category: Organic Light Emitting Diode (OLED). CAS No. 1470161-29-5. Molecular formula: C48H32N2O. Mole weight: 652.78 g/mol. Product ID: ACM1470161295. Alfa Chemistry ISO 9001:2015 Certified. Categories: CB Peñas Huesca. | |
| CBD-1 | CBD-1 is isolated from Canis lupus. It has antibacterial and antifungal activity. | |
| CB-DMB | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| CBF? Activator, Kartogenin | The CBF? Activator, Kartogenin modulates the biological activity of CBF?. This small molecule/inhibitor is primarily used for Biochemicals applications. Group: Fluorescence/luminescence spectroscopy. | |
| CBFβ Inhibitor | Core binding factors (CBFs) are heterodimeric transcription factors containing a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBF&beta. CBFβ Inhibitor cellular studies indicate a good correlation between the inhibitor's antiproliferative activity and the Runx1 expression level in the target cells. Synonyms: Core Binding Factor-β Inhibitor; 2-Thiazolamine, 5-ethyl-4-(4-methoxyphenyl)-; 5-Ethyl-4-(4-methoxyphenyl)-2-thiazolamine; Sc 221405; 5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine. Grades: ≥98%. CAS No. 493028-20-9. Molecular formula: C12H14N2OS. Mole weight: 234.32. | |
| CBF beta-Runx1 Inhibitor II, Ro5-3335 ([7-chloro-5-(2-pyrryl)-3H-1,4 benzodiazapin-2-(H)-one], Ro53335, CBFalpha-CBFbeta Inhibitor II) | A cell-permeable benzodiazepine that suppresses CBFalpha/Runx1-CBFbeta transactivation activity (25uM; 293-0 cells) via direct bindings to both subunits of the heterodimeric transcription factor complex. Shown to inhibit oncogenic fusion CBFB-MYH11-, TEL-RUNX1-, and RUNX1-ETO-, dependent leukemia cells proliferation (IC50 = 1.1 to 21.7uM) in vitro and more effectively reduce peripheral blood c-kit+ population (300mg/kg/d via animal feed) than Cytarabine in a murine Cbfb-MYH11 leukemia model in vivo. Comparing to CBFbeta-Runx1 Inhibitor I, Ro5-3335 modulates the Runx1-CBFbeta heterodimer formation without completely disrupting the subunits interaction. Group: Biochemicals. Grades: Highly Purified. CAS No. 30195-30-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| CBHA | Histone deacetylase (HDAC) inhibitors hyperacetylate histones and increase transcriptional activity in selected genes. CBHA is a cell-permeable second generation hybrid polar agent that acts as a HDAC inhibitor. It exhibits ID50 values of 0.01 and 0.07 μM in vitro for HDAC1 and HDAC3, respectively. CBHA also induces apoptosis in nine different neuroblastoma cell lines in culture. Uses: Histone deacetylase inhibitors. Synonyms: Histone Deacetylase Inhibitor II; m-Carboxycinnamic acid bis-hydroxamide. Grades: ≥98%. CAS No. 174664-65-4. Molecular formula: C10H10N2O4. Mole weight: 222.2. | |
| Cbi-bb zero/001606 | Cbi-bb zero/001606. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CBI-BB ZERO/001606;TIMTEC-BB SBB001518;4,6-DIMETHYL-1,2,4-TRIAZOLO[1,5-A]PYRIMIDINE-2-SULPHONYL CHLORIDE;5,7-DIMETHYL-1,2,4-TRIAZOLO [1,5A] PYRIMIDINE SULPHONYL CHLORIDE. Product Category: Heterocyclic Organic Compound. CAS No. 98169-74-5. Molecular formula: C7H7ClN4O2S. Mole weight: 246.67. Product ID: ACM98169745. Alfa Chemistry ISO 9001:2015 Certified. | |
| Cbi-bb zero/006283 | Cbi-bb zero/006283. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CHEMBRDG-BB 9071636;CBI-BB ZERO/006283;2-HYDROXY-3-(2-METHYLPHENOXY)PROPANOIC ACID;PROPANOIC ACID, 2-HYDROXY-3-(2-METHYLPHENOXY)-;TIMTEC-BB SBB014000. Product Category: Heterocyclic Organic Compound. CAS No. 26114-38-5. Molecular formula: C10H12O4. Mole weight: 196.2. Product ID: ACM26114385. Alfa Chemistry ISO 9001:2015 Certified. | |
| CBiPES hydrochloride | CBiPES hydrochloride is a selective positive allosteric modulator of the mGlu2 receptor (IC50 = 98.2 nM). Synonyms: N-(4'-Cyano-[1,1'-biphenyl]-3-yl-N-(3-pyridinylmethyl)-ethanesulfonamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 856702-40-4. Molecular formula: C21H19N3O2S.HCl. Mole weight: 413.92. | |
| CBiPES hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| CBiPES hydrochloride | CBiPES hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 856702-40-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| CBIQ | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| CBL0137 | CBL0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 μM and inhibits NF-κB with an EC50 of 0.47 μM. It also inhibits histone chaperone FACT (facilitates chromatin transcription) and MYC signal. Synonyms: CBL0137; CBL-0137; CBL 0137; CBLC137; CBLC-137; CBLC 137; Curaxin 137; 1,1'-(9-(2-(Isopropylamino)ethyl)-9H-carbazole-3,6-diyl)diethanone; 1-[6-acetyl-9-[2-(propan-2-ylamino)ethyl]carbazol-3-yl]ethanone. CAS No. 1197996-80-7. Molecular formula: C21H24N2O2. Mole weight: 336.435. | |
| CBL0137 | CBL0137, a curaxin compound, is a histone chaperone facilitates chromatin transcription (FACT) inhibitor. CBL0137 downregulates NF- B and activates p53. CBL0137 restores both histone H3 acetylation and trimethylation. CBL0137 is an anticancer agent. CBL0137 induces cancer cell apoptosis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Curaxin 137; CBL-C137. CAS No. 1197996-80-7. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18935. | |
| CBL0137 hydrochloride | CBL0137 hydrochloride is an inhibitor of the histone chaperone, FACT. CBL0137 hydrochloride can also activate p53 and inhibits NF-κB with EC 50 s of 0.37 and 0.47 μM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Curaxin-137 hydrochloride; CBL-C137 hydrochloride. CAS No. 1197397-89-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18935A. | |
| CBL0137 hydrochloride | NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. CBL0137 activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It functionally inactivates the facilitates chromatin transcription complex, driving the effects on p53 and NF-κB and promoting cancer cell death. Synonyms: CBLC137; CBL-0137; Curaxin 137. Grades: ≥98%. CAS No. 1197397-89-9. Molecular formula: C21H24N2O2·HCl. Mole weight: 372.9. | |
| Cbl-b-IN-1 | Cbl-b-IN-1 (Example 519) is an inhibitor of Cbl-b, with an IC50 of less than 100 nM. Cbl-b-IN-1 can promote the secretion of cytokines such as IL-2, IFN-?, and TNF-?, facilitate T cell activation, and enhance the TCR signaling pathway. Cbl-b-IN-1 can be used in research on immunomodulation[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2368841-84-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136339. | |
| CBLC000 trifluoroacetate | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| CBM 301940 | Malonyl-CoA decarboxylase (MCD) is found from bacteria to humans, which has important roles in regulating fatty acid metabolism and food intake. CBM 301940 is a potent malonyl-CoA decarboxylase (MCD) inhibitor with IC50 of 23 nM. It suppresses malonyl-CoA degradation and fatty acid oxidation in isolated rat hearts, leading to secondary increase in glucose oxidation. Synonyms: (2S,3R,4S)-3-ethenyl-2-(beta-D-glucopyranosyloxy)-3,4-dihydro-4-(2-oxoethyl)-2H-pyran-5-carboxylic acid, methyl ester; CBM301940; CBM-301940. Grades: ≥98%. CAS No. 902146-11-6. Molecular formula: C15H20F6N2O5. Mole weight: 422.32. | |
| C(Boc) Acetic acid | A nucleobase for PNA synthesis. Synonyms: 2-Oxo-4-(tert-butoxycarbonylamino)-1,2-dihydropyrimidine-1-acetic acid; 2-(4-((Tert-Butoxycarbonyl)Amino)-2-Oxopyrimidin-1(2H)-yl)Acetic acid. Grades: 98%. CAS No. 172405-16-2. Molecular formula: C11H15N3O5. Mole weight: 269.25. | |
| CBP | CBP. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4,4'-Bis(carbazol-9-yl)biphenyl. Product Category: Organic Light Emitting Diode (OLED). CAS No. 58328-31-7. Molecular formula: C36H24N2. Mole weight: 484.59 g/mol. Purity: 95%+. IUPACName: 9-[4-(4-carbazol-9-ylphenyl)phenyl]carbazole. Canonical SMILES: C1=CC=C2C(=C1)C3=CC=CC=C3N2C4=CC=C(C=C4)C5=CC=C(C=C5)N6C7=CC=CC=C7C8=CC=CC=C86. Density: 1.19 g/ml. Product ID: ACM58328317. Alfa Chemistry ISO 9001:2015 Certified. | |
| CBP (1319-1710), GST tagged human | recombinant, expressed in E. coli, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| CBP501 | CBP501 is a peptide with G2 checkpoint-abrogating activity. G2 checkpoint inhibitor CBP501 inhibits multiple serine/threonine kinases, including MAPKAP-K2, C-Tak1, and CHK1, that phosphorylate serine 216 of the dual-specific phosphatase Cdc25C (cell division checkpoint 25 C); disruption of Cdc25C activity results in the inhibition of Cdc25C dephosphorylation of the mitotic cyclin-dependent kinase complex Cdc2/cyclin B, preventing entry into the mitotic phase of the cell cycle. Check for active clinical trials or closed clinical trials using this agent. Synonyms: CBP-501; CBP 501; H-D-Bpa-D-Ser-D-Trp-D-Ser-D-Phe(F5)-D-Cha-D-Arg-D-Arg-D-Arg-D-Gln-D-Arg-D-Arg-OH. CAS No. 565434-85-7. Molecular formula: C86H122F5N29O17. Mole weight: 1929.06. | |
| CBP501 Affinity Peptide | CBP501 Affinity Peptide exhibits similarity to part of the human 14-3-3e αC helix, suggesting that CBP501 may bind to this region. Synonyms: H-Asn-Ser-Asp-Cys-Ile-Ile-Ser-Arg-Lys-Ile-Glu-Gln-Lys-Glu-OH; L-Glutamic acid, L-asparaginyl-L-seryl-L-α-aspartyl-L-cysteinyl-L-isoleucyl-L-isoleucyl-L-seryl-L-arginyl-L-lysyl-L-isoleucyl-L-α-glutamyl-L-glutaminyl-L-lysyl-. Grades: ≥95%. CAS No. 1351804-17-5. Molecular formula: C68H119N21O25S. Mole weight: 1662.89. | |
| CBP-93872 | CBP-93872 is a G2 checkpoint inhibitor. CBP-93872 specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint through inhibiting maintenance. CBP-93872 is an inhibitor of maintenance of the DSB-specific G2 checkpoint and thus might be a strong candidate as the basis for a drug that specifically sensitizes p53-mutated cancer cells to DSB-inducing DNA damage therapy. Synonyms: CBP 93872; CBP93872; 1-amino-3-((2-bromo-4-methylphenyl)amino)propan-2-ol. Grades: 98%. CAS No. 67427-51-4. Molecular formula: C10H15BrN2O. Mole weight: 259.14. | |
| CBP-aminomethylenevancomycin | CBP-aminomethylenevancomycin is an analogue of vancomycin which overcomes the drug resistance and induces cell permeability. It significantly increases the antibacterial activity and decreases the side effects. Uses: Antibacterial agent. Synonyms: CBP aminomethylenevancomycin. | |
| CBP-C1-aminomethylenevancomycin | CBP-C1-aminomethylenevancomycin is an analogue of vancomycin which overcomes the drug resistance and induces cell permeability. It significantly increases the antibacterial activity and decreases the side effects. Uses: Antibacterial agent. Synonyms: CBP C1 aminomethylenevancomycin. | |
| CBPD-409 | CBPD-409 is an orally active PROTAC degrader for CBP/p300, with DC50 of 0.2-0.4 nM. CBPD-409 exhibits antiproliferative effects in AR+ prostate cancer cell lines VCaP, LNCaP and 22Rv1, with IC50s of 1.2-2.0 nM. CBPD-409 exhibits antitumor efficacy (Red: CBP inhibitor GNE049 (HY-108435); Blue: CRBN/cullin 4A Thalidomide (HY-14658); Black: Linker)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3037549-86-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-158113. | |
| CBP-iminomethylenevancomycin | CBP-iminomethylenevancomycin is an analogue of vancomycin which overcomes the drug resistance and induces cell permeability. It significantly increases the antibacterial activity and decreases the side effects. Uses: Antibacterial agent. Synonyms: CBP iminomethylenevancomycin. | |
| CBP/p300-IN-19 hydrochloride | CBP/p300-IN-19 hydrochloride is a potent and selective p300/CBP HAT inhibitor with IC 50 s of 1.4, 2.2, >100, >100 μM for p300-HAT, CBP-HAT, PCAF, Myst3, respectively. CBP/p300-IN-19 hydrochloride shows antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2592638-14-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-146277A. | |
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