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| Product | Description | |
|---|---|---|
| CB-6644 | CB-6644 is a novel allosteric selective inhibitor of the ruvbl1/2 complex with anti-cancer activity. CB-6644 blocks the ATPase activity of RUVBL1/2 with an IC50 of 15 nM. CB-6644 interacts specifically with RUVBL1/2 in cancer cells, leading to cell death. Importantly, drug-acquired-resistant cell clones have amino acid mutations in either RUVBL1 or RUVBL2, suggesting that cell killing is an on-target consequence of RUVBL1/2 engagement. In xenograft models of acute myeloid leukemia and multiple myeloma, CB-6644 significantly reduced tumor growth without obvious toxicity. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CB-6644; CB 6644; CB6644. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2316817-88-4. Molecular formula: C29H34ClFN4O5. Mole weight: 573.06. Purity: >96%. IUPACName: 5-Chloro-2-ethoxy-4-fluoro-N-(4-((3-(methoxymethyl)-1-oxo-6,7-dihydro-1H,5H-benzo[c]pyrazolo[1,2-a][1,2]diazepin-2-yl)amino)-2,2-dimethyl-4-oxobutyl)benzamide. Canonical SMILES: O=C(NCC(C)(C)CC(NC(C1=O)=C(COC)N2N1C3=CC=CC=C3CCC2)=O)C4=CC(Cl)=C(F)C=C4OCC. Product ID: ACM2316817884. Alfa Chemistry ISO 9001:2015 Certified. |  |
| CB7646 | CB7646 is a stable analogue of trimelamol (TM). It is used as an anti-tumour agent. Uses: Cb7646 is used as an anti-tumour agent. Synonyms: CB-7646; CB 7646; CB7646; UNII-LYO93N5MEB. Methanol, ((6-(methylamino)-1,3,5-triazine-2,4-diyl)bis(methylimino))bis-; [[4-[Hydroxymethyl(methyl)amino]-6-(methylamino)-1,3,5-triazin-2-yl]-methylamino]methanol. Grade: >98 %. CAS No. 104880-54-8. Molecular formula: C8H16N6O2. Mole weight: 228.25. |  |
| CB-7921220 | CB-7921220 is an adenylate cyclase inhibitor which is selective, reducing adenylyl cyclase type I and VI activity by 60% while having no effect on types II and V in Sf9 membranes stimulated by forskolin at a concentration of 100 μM. CB-7921220 has a binding conformation similar to ATP and P-site inhibitors, which may explain its lack of selectivity between AC1 and AC6. Synonyms: CB7921220; CB 7921220; CB-7921220; 6-[(E)-2-(4-aminophenyl)ethenyl]pyridine-2-carboxylic acid. CAS No. 115453-99-1. Molecular formula: C14H12N2O2. Mole weight: 240.26. | |
| CB-839 | CB-839 an is orally bioavailable inhibitor of glutaminase, with potential antineoplastic activity. Upon oral administration, CB-839 selectively and irreversibly inhibits glutaminase, a mitochondrial enzyme that is essential for the conversion of the amino acid glutamine into glutamate. By blocking glutamine utilization, proliferation in rapidly growing cells is impaired. Glutamine-dependent tumors rely on the conversion of exogenous glutamine into glutamate and glutamate metabolites to both provide energy and generate building blocks for the production of macromolecules, which are needed for cellular growth and survival. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). ( ). Synonyms: CB-839; CB839; CB 839. Grade: 98%. CAS No. 1439399-58-2. Molecular formula: C26H24F3N7O3S. Mole weight: 571.57. | |
| CB-86 | Cannabinoid receptors (CB) are of a class of cell membrane receptors in the G protein-coupled receptor superfamily. CB-86 is a resorcinol-anandamide hybrid compound that acts as a partial agonist for the CB1 receptor with Ki of 5.6 nM and a neutral antagonist for CB2 receptor with Ki of 7.9 nM. CB-86 exhibits antinociceptive effects in mice treated with formalin. Synonyms: CB86; CB 86. Grade: ≥98%. CAS No. 1150586-64-3. Molecular formula: C26H43NO3. Mole weight: 417.6. | |
| CB 966 | CB 966 is a novel analogues of 1,25-dihydroxyvitamin D3 and it was found to significantly delay the rejection of allogeneic skin grafts in CBA (H-2k) recipient mice. Synonyms: CB 966; CB966; CB-966. (1R-(1alpha(R*),3abeta,4E(1R*,3S*,5Z),7aalpha))-5-((1-(6-ethyl-6-hydroxy-1-methyloctyl)octahydro-7a-methyl-4H-inden-4-ylidene)ethylidene)-4-methylene-1,3-Cyclohexanediol. Grade: 98%. CAS No. 128312-71-0. Molecular formula: C30H50O3. Mole weight: 458.72. | |
| CBA | Transient Receptor Potential Cation Channel Subfamily M Member 4 (TRPM 4) is a Protein Coding gene. Diseases associated with TRPM4 include Progressive Familial Heart Block, Type Ib and Erythrokeratodermia Variabilis Et Progressiva. TRPM4-IN-5 is a potent and selective inhibitor of the cation channel TRPM4 blocker with IC 50 of 1.5 μM. Synonyms: 4-Chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid; TRPM4-IN-5; TRPM4IN-5; TRPM4-IN5; TRPM4 IN-5. Grade: ≥98%. CAS No. 351424-20-9. Molecular formula: C15H11Cl2NO4. Mole weight: 340.16. | |
| CBB1003 | CBB1003, a piperazine derivative, has been found to be a histone demethylase LSD1 inhibitor that could restrain the proliferation and colony formation of CRC cell in mice. IC50: 10.54 uM. Uses: Cbb1003 has been found to be a histone demethylase lsd1 inhibitor that could restrain the proliferation and colony formation of crc cell in mice. Synonyms: CBB1003; SCHEMBL16273292; CS-3476. Grade: 98%. CAS No. 1379573-88-2. Molecular formula: C25H31N9O4. Mole weight: 521.57. | |
| CBB1003 hydrochloride | CBB1003 hydrochloride is an inhibitor of histone demethylase LSD1 with an IC50 of 10.54 μM. Synonyms: 4-(3-{[4-(4-Carbamimidoylbenzoyl)-1-piperazinyl]carbonyl}-5-nitrobenzyl)-1-piperazinecarboximidamide pentahydrochloride; 1-Piperazinecarboximidamide, 4-[[3-[[4-[4-(aminoiminomethyl)benzoyl]-1-piperazinyl]carbonyl]-5-nitrophenyl]methyl]-, hydrochloride (1:5). Molecular formula: C25H36Cl5N9O4. Mole weight: 703.88. | |
| CBB1007 | CBB1007, an amidino-guanidinium derivative, has been found to have biological activity in anticancer-study by acting as a LSD1 inhibitor. IC50: 5.27 uM. Uses: Cbb1007 has been found to have biological activity in anticancer-study by acting as a lsd1 inhibitor. Synonyms: CBB1007; SCHEMBL16273312; CS-1737. Grade: 98%. CAS No. 1379573-92-8. Molecular formula: C27H34N8O4. Mole weight: 534.61. | |
| CBB1007 hydrochloride | CBB1007 hydrochloride, a cell-permeable amidino-guanidinium compound, is a potent, reversible and substrate competitive LSD1 selective inhibitor with an IC50 of 5.27 μM for hLSD1. Synonyms: Methyl 3-{[4-(4-carbamimidoylbenzoyl)-1-piperazinyl]carbonyl}-5-[(4-carbamimidoyl-1-piperazinyl)methyl]benzoate pentahydrochloride; Benzoic acid, 3-[[4-[4-(aminoiminomethyl)benzoyl]-1-piperazinyl]carbonyl]-5-[[4-(aminoiminomethyl)-1-piperazinyl]methyl]-, methyl ester, hydrochloride (1:5). Grade: ≥98%. Molecular formula: C27H39Cl5N8O4. Mole weight: 716.91. | |
| CBB1007 trihydrochloride | CBB1007 trihydrochloride, a cell-permeable amidino-guanidinium compound, is a potent, reversible and substrate competitive LSD1 selective inhibitor with an IC50 of 5.27 μM for hLSD1. Synonyms: Methyl 3-{[4-(4-carbamimidoylbenzoyl)-1-piperazinyl]carbonyl}-5-[(4-carbamimidoyl-1-piperazinyl)methyl]benzoate trihydrochloride; Benzoic acid, 3-[[4-[4-(aminoiminomethyl)benzoyl]-1-piperazinyl]carbonyl]-5-[[4-(aminoiminomethyl)-1-piperazinyl]methyl]-, methyl ester, hydrochloride (1:3). Grade: ≥96%. Molecular formula: C27H37Cl3N8O4. Mole weight: 643.99. | |
| CbBPCb | CbBPCb. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3,3'-Di(9H-pyrido[2,3-b]-indol-9-yl)biphenyl. Product Category: Organic Light Emitting Diode (OLED). CAS No. 1469997-91-8. Molecular formula: C34H22N4. Mole weight: 486.57 g/mol. Product ID: ACM1469997918. Alfa Chemistry ISO 9001:2015 Certified. | |
| CBBPE | CBBPE. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9,9'-(Oxybis([1,1'-biphenyl]-4',3-diyl))bis(9H-carbazole). Product Category: Organic Light Emitting Diode (OLED). CAS No. 1470161-29-5. Molecular formula: C48H32N2O. Mole weight: 652.78 g/mol. Product ID: ACM1470161295. Alfa Chemistry ISO 9001:2015 Certified. Categories: CB Peñas Huesca. | |
| CBD-1 | CBD-1 is isolated from Canis lupus. It has antibacterial and antifungal activity. | |
| CB-DMB | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| CBF? Activator, Kartogenin | The CBF? Activator, Kartogenin modulates the biological activity of CBF?. This small molecule/inhibitor is primarily used for Biochemicals applications. Group: Fluorescence/luminescence spectroscopy. | |
| CBFβ Inhibitor | Core binding factors (CBFs) are heterodimeric transcription factors containing a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBFβ Inhibitor cellular studies indicate a good correlation between the inhibitor's antiproliferative activity and the Runx1 expression level in the target cells. Synonyms: Core Binding Factor-β Inhibitor; 2-Thiazolamine, 5-ethyl-4-(4-methoxyphenyl)-; 5-Ethyl-4-(4-methoxyphenyl)-2-thiazolamine; Sc 221405; 5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine. Grade: ≥98%. CAS No. 493028-20-9. Molecular formula: C12H14N2OS. Mole weight: 234.32. | |
| CBF beta-Runx1 Inhibitor II, Ro5-3335 ([7-chloro-5-(2-pyrryl)-3H-1,4 benzodiazapin-2-(H)-one], Ro53335, CBFalpha-CBFbeta Inhibitor II) | A cell-permeable benzodiazepine that suppresses CBFalpha/Runx1-CBFbeta transactivation activity (25uM; 293-0 cells) via direct bindings to both subunits of the heterodimeric transcription factor complex. Shown to inhibit oncogenic fusion CBFB-MYH11-, TEL-RUNX1-, and RUNX1-ETO-, dependent leukemia cells proliferation (IC50 = 1.1 to 21.7uM) in vitro and more effectively reduce peripheral blood c-kit+ population (300mg/kg/d via animal feed) than Cytarabine in a murine Cbfb-MYH11 leukemia model in vivo. Comparing to CBFbeta-Runx1 Inhibitor I, Ro5-3335 modulates the Runx1-CBFbeta heterodimer formation without completely disrupting the subunits interaction. Group: Biochemicals. Grades: Highly Purified. CAS No. 30195-30-3. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| CBHA | Histone deacetylase (HDAC) inhibitors hyperacetylate histones and increase transcriptional activity in selected genes. CBHA is a cell-permeable second generation hybrid polar agent that acts as a HDAC inhibitor. It exhibits ID50 values of 0.01 and 0.07 μM in vitro for HDAC1 and HDAC3, respectively. CBHA also induces apoptosis in nine different neuroblastoma cell lines in culture. Uses: Histone deacetylase inhibitors. Synonyms: Histone Deacetylase Inhibitor II; m-Carboxycinnamic acid bis-hydroxamide. Grade: ≥98%. CAS No. 174664-65-4. Molecular formula: C10H10N2O4. Mole weight: 222.2. | |
| Cbi-bb zero/001606 | Cbi-bb zero/001606. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CBI-BB ZERO/001606;TIMTEC-BB SBB001518;4,6-DIMETHYL-1,2,4-TRIAZOLO[1,5-A]PYRIMIDINE-2-SULPHONYL CHLORIDE;5,7-DIMETHYL-1,2,4-TRIAZOLO [1,5A] PYRIMIDINE SULPHONYL CHLORIDE. Product Category: Heterocyclic Organic Compound. CAS No. 98169-74-5. Molecular formula: C7H7ClN4O2S. Mole weight: 246.67. Product ID: ACM98169745. Alfa Chemistry ISO 9001:2015 Certified. | |
| Cbi-bb zero/006283 | Cbi-bb zero/006283. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CHEMBRDG-BB 9071636;CBI-BB ZERO/006283;2-HYDROXY-3-(2-METHYLPHENOXY)PROPANOIC ACID;PROPANOIC ACID, 2-HYDROXY-3-(2-METHYLPHENOXY)-;TIMTEC-BB SBB014000. Product Category: Heterocyclic Organic Compound. CAS No. 26114-38-5. Molecular formula: C10H12O4. Mole weight: 196.2. Product ID: ACM26114385. Alfa Chemistry ISO 9001:2015 Certified. | |
| CBiPES hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| CBiPES hydrochloride | CBiPES hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 856702-40-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| CBiPES hydrochloride | CBiPES hydrochloride is a selective positive allosteric modulator of the mGlu2 receptor (IC50 = 98.2 nM). Synonyms: N-(4'-Cyano-[1,1'-biphenyl]-3-yl-N-(3-pyridinylmethyl)-ethanesulfonamide hydrochloride. Grade: ≥99% by HPLC. CAS No. 856702-40-4. Molecular formula: C21H19N3O2S.HCl. Mole weight: 413.92. | |
| CBIQ | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| CBL0137 | CBL0137, a curaxin compound, is a histone chaperone facilitates chromatin transcription (FACT) inhibitor. CBL0137 downregulates NF- B and activates p53. CBL0137 restores both histone H3 acetylation and trimethylation. CBL0137 is an anticancer agent. CBL0137 induces cancer cell apoptosis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Curaxin 137; CBL-C137. CAS No. 1197996-80-7. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18935. |  |
| CBL0137 | CBL0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 μM and inhibits NF-κB with an EC50 of 0.47 μM. It also inhibits histone chaperone FACT (facilitates chromatin transcription) and MYC signal. Synonyms: CBL0137; CBL-0137; CBL 0137; CBLC137; CBLC-137; CBLC 137; Curaxin 137; 1,1'-(9-(2-(Isopropylamino)ethyl)-9H-carbazole-3,6-diyl)diethanone; 1-[6-acetyl-9-[2-(propan-2-ylamino)ethyl]carbazol-3-yl]ethanone. CAS No. 1197996-80-7. Molecular formula: C21H24N2O2. Mole weight: 336.435. | |
| CBL0137 hydrochloride | NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. CBL0137 activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It functionally inactivates the facilitates chromatin transcription complex, driving the effects on p53 and NF-κB and promoting cancer cell death. Synonyms: CBLC137; CBL-0137; Curaxin 137. Grade: ≥98%. CAS No. 1197397-89-9. Molecular formula: C21H24N2O2·HCl. Mole weight: 372.9. | |
| CBL0137 hydrochloride | CBL0137 hydrochloride is an inhibitor of the histone chaperone, FACT. CBL0137 hydrochloride can also activate p53 and inhibits NF-κB with EC 50 s of 0.37 and 0.47 μM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Curaxin-137 hydrochloride; CBL-C137 hydrochloride. CAS No. 1197397-89-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18935A. | |
| Cbl-b-IN-1 | Cbl-b-IN-1 (Example 519) is an inhibitor of Cbl-b, with an IC50 of less than 100 nM. Cbl-b-IN-1 can promote the secretion of cytokines such as IL-2, IFN-?, and TNF-?, facilitate T cell activation, and enhance the TCR signaling pathway. Cbl-b-IN-1 can be used in research on immunomodulation[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2368841-84-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136339. | |
| Cbl-b-IN-3 | Cbl-b-IN-3 inhibits proto-oncogene-B (CPL-B). CBL-B is an E3 ubiquitin ligase that ubiquitinates proteins downstream of immune receptors to downregulate positive signaling cascades. Synonyms: 2-{3-[(1S,3R)-3-methyl-1-(4-methyl-4H-1,2,4-triazol-3-yl)cyclobutyl]phenyl}-6-{[(3S)-3-methylpiperidin-1-yl]methyl}-4-(trifluoromethyl)-2,3-dihydro-1H-isoindol-1-one. Grade: >98.0%. CAS No. 2573775-59-2. Molecular formula: C30H34F3N5O. Mole weight: 537.63. | |
| CBLC000 trifluoroacetate | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| CBM 301940 | Malonyl-CoA decarboxylase (MCD) is found from bacteria to humans, which has important roles in regulating fatty acid metabolism and food intake. CBM 301940 is a potent malonyl-CoA decarboxylase (MCD) inhibitor with IC50 of 23 nM. It suppresses malonyl-CoA degradation and fatty acid oxidation in isolated rat hearts, leading to secondary increase in glucose oxidation. Synonyms: (2S,3R,4S)-3-ethenyl-2-(beta-D-glucopyranosyloxy)-3,4-dihydro-4-(2-oxoethyl)-2H-pyran-5-carboxylic acid, methyl ester; CBM301940; CBM-301940. Grade: ≥98%. CAS No. 902146-11-6. Molecular formula: C15H20F6N2O5. Mole weight: 422.32. | |
| CBP | CBP. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4,4'-Bis(carbazol-9-yl)biphenyl. Product Category: Organic Light Emitting Diode (OLED). CAS No. 58328-31-7. Molecular formula: C36H24N2. Mole weight: 484.59 g/mol. Purity: 95%+. IUPACName: 9-[4-(4-carbazol-9-ylphenyl)phenyl]carbazole. Canonical SMILES: C1=CC=C2C(=C1)C3=CC=CC=C3N2C4=CC=C(C=C4)C5=CC=C(C=C5)N6C7=CC=CC=C7C8=CC=CC=C86. Density: 1.19 g/ml. Product ID: ACM58328317. Alfa Chemistry ISO 9001:2015 Certified. | |
| CBP (1319-1710), GST tagged human | recombinant, expressed in E. coli, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| CBP501 | CBP501 is a peptide with G2 checkpoint-abrogating activity. G2 checkpoint inhibitor CBP501 inhibits multiple serine/threonine kinases, including MAPKAP-K2, C-Tak1, and CHK1, that phosphorylate serine 216 of the dual-specific phosphatase Cdc25C (cell division checkpoint 25 C); disruption of Cdc25C activity results in the inhibition of Cdc25C dephosphorylation of the mitotic cyclin-dependent kinase complex Cdc2/cyclin B, preventing entry into the mitotic phase of the cell cycle. Check for active clinical trials or closed clinical trials using this agent. Synonyms: CBP-501; CBP 501; H-D-Bpa-D-Ser-D-Trp-D-Ser-D-Phe(F5)-D-Cha-D-Arg-D-Arg-D-Arg-D-Gln-D-Arg-D-Arg-OH. CAS No. 565434-85-7. Molecular formula: C86H122F5N29O17. Mole weight: 1929.06. | |
| CBP501 Affinity Peptide | CBP501 Affinity Peptide exhibits similarity to part of the human 14-3-3e αC helix, suggesting that CBP501 may bind to this region. Synonyms: H-Asn-Ser-Asp-Cys-Ile-Ile-Ser-Arg-Lys-Ile-Glu-Gln-Lys-Glu-OH; L-Glutamic acid, L-asparaginyl-L-seryl-L-α-aspartyl-L-cysteinyl-L-isoleucyl-L-isoleucyl-L-seryl-L-arginyl-L-lysyl-L-isoleucyl-L-α-glutamyl-L-glutaminyl-L-lysyl-. Grade: ≥95%. CAS No. 1351804-17-5. Molecular formula: C68H119N21O25S. Mole weight: 1662.89. | |
| CBP-93872 | CBP-93872 is a G2 checkpoint inhibitor. CBP-93872 specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint through inhibiting maintenance. CBP-93872 is an inhibitor of maintenance of the DSB-specific G2 checkpoint and thus might be a strong candidate as the basis for a drug that specifically sensitizes p53-mutated cancer cells to DSB-inducing DNA damage therapy. Synonyms: CBP 93872; CBP93872; 1-amino-3-((2-bromo-4-methylphenyl)amino)propan-2-ol. Grade: 98%. CAS No. 67427-51-4. Molecular formula: C10H15BrN2O. Mole weight: 259.14. | |
| CBP-aminomethylenevancomycin | CBP-aminomethylenevancomycin is an analogue of vancomycin which overcomes the drug resistance and induces cell permeability. It significantly increases the antibacterial activity and decreases the side effects. Uses: Antibacterial agent. Synonyms: CBP aminomethylenevancomycin. | |
| CBP-C1-aminomethylenevancomycin | CBP-C1-aminomethylenevancomycin is an analogue of vancomycin which overcomes the drug resistance and induces cell permeability. It significantly increases the antibacterial activity and decreases the side effects. Uses: Antibacterial agent. Synonyms: CBP C1 aminomethylenevancomycin. | |
| CBPD-409 | CBPD-409 is an orally active PROTAC degrader for CBP/p300, with DC50 of 0.2-0.4 nM. CBPD-409 exhibits antiproliferative effects in AR+ prostate cancer cell lines VCaP, LNCaP and 22Rv1, with IC50s of 1.2-2.0 nM. CBPD-409 exhibits antitumor efficacy (Red: CBP inhibitor GNE049 (HY-108435); Blue: CRBN/cullin 4A Thalidomide (HY-14658); Black: Linker)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3037549-86-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-158113. | |
| CBP/EP300-IN-2 | CBP/EP300-IN-2 is a CBP/EP300 inhibitor with IC50s of 1.07 and 5.96 nM for CBP/HTRF and Myc, respectively. (Extracted from patent WO2017205538A1, example 25). Synonyms: 5H-Pyrazolo[4,3-c]pyridine-5-carboxamide, 3-[6-(difluoromethyl)-7-(1-methyl-1H-pyrazol-4-yl)-4-isoquinolinyl]-1,4,6,7-tetrahydro-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-; CBP/p300-IN-2; 3-[6-(Difluoromethyl)-7-(1-methyl-1H-pyrazol-4-yl)-4-isoquinolinyl]-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide. Grade: ≥95%. CAS No. 2158265-96-2. Molecular formula: C27H29F2N7O2. Mole weight: 521.56. | |
| CBP-iminomethylenevancomycin | CBP-iminomethylenevancomycin is an analogue of vancomycin which overcomes the drug resistance and induces cell permeability. It significantly increases the antibacterial activity and decreases the side effects. Uses: Antibacterial agent. Synonyms: CBP iminomethylenevancomycin. | |
| CBP/p300-IN-1 | CBP/p300-IN-1 is an inhibitor of CBP/EP300 bromodomain. Synonyms: 2-Methyl-2-propanyl 3-{[(1-acetyl-5-methoxy-1H-indol-3-yl)carbonyl]amino}-4-fluorobenzoate; tert-Butyl 3-(1-acetyl-5-methoxy-1H-indole-3-carboxamido)-4-fluorobenzoate; Benzoic acid, 3-[[(1-acetyl-5-methoxy-1H-indol-3-yl)carbonyl]amino]-4-fluoro-, 1,1-dimethylethyl ester. Grade: ≥95%. CAS No. 2443789-32-8. Molecular formula: C23H23FN2O5. Mole weight: 426.44. | |
| CBP/p300-IN-12 | CBP/p300-IN-12 is a potent and selective covalent histone acetyltransferases p300 (IC50 = 166 nM) and CBP inhibitor that reduces H3K27Ac levels in PC-3 cells (EC50 = 37 nM). CBP/p300-IN-12 forms a covalent adduct with C1450. Synonyms: N-(3-(3-((R)-3'-(2-((4-fluorobenzyl)((S)-1,1,1-trifluoropropan-2-yl)amino)-2-oxoethyl)-2',4'-dioxo-2,3-dihydrospiro[indene-1,5'-oxazolidin]-5-yl)ureido)phenyl)acrylamide. Molecular formula: C33H29F4N5O6. Mole weight: 667.61. | |
| CBP/p300-IN-14 | CBP/p300-IN-14 is a potent CBP/EP300 (lysine acetyltransferase) inhibitor with an IC50 of 3.3 nM. (Extracted from patent WO2021213521A1, compound 27). Synonyms: 3-Isoquinolinecarboxamide, 1-[7-(difluoromethyl)-3,4-dihydro-6-(1-methyl-1H-pyrazol-4-yl)-1(2H)-quinolinyl]-N-methyl-6-(4-methyl-2-oxo-1-piperazinyl)-; 1-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-methyl-6-(4-methyl-2-oxopiperazin-1-yl)isoquinoline-3-carboxamide. CAS No. 2725036-10-0. Molecular formula: C30H31F2N7O2. Mole weight: 559.61. | |
| CBP/p300-IN-19 hydrochloride | CBP/p300-IN-19 hydrochloride is a potent and selective p300/CBP HAT inhibitor with IC 50 s of 1.4, 2.2, >100, >100 μM for p300-HAT, CBP-HAT, PCAF, Myst3, respectively. CBP/p300-IN-19 hydrochloride shows antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2592638-14-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-146277A. | |
| CBP/p300-IN-5 | P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase with an IC50 of 18.8 nM. (Extracted from patent WO2016044770A1, Example 715). Synonyms: CBP/p300-IN-5; 2-[4-[(3'R,4S)-3'-fluoro-1-[2-[(4-fluorophenyl)methyl-[(1S)-2,2,2-trifluoro-1-methyl-ethyl]amino]-2-oxo-ethyl]-2,5-dioxo-spiro[imidazolidine-4,1'-indane]-5'-yl]pyrazol-1-yl]-N-methylacetamide; 2-((3'R,4S)-3'-Fluoro-5'-(1-(2-(methylamino)-2-oxoethyl)-1H-pyrazol-4-yl)-2,5-dioxo-2',3'-dihydrospiro[imidazolidine-4,1'-inden]-1-yl)-N-(4-fluorobenzyl)-N-((S)-1,1,1-trifluoropropan-2-yl)acetamide; N-(4-Fluorobenzyl)-2-[(3'R,4S)-3'-fluoro-5'-{1-[2-(methylamino)-2-oxoethyl]-1H-pyrazol-4-yl}-2,5-dioxo-2',3'-dihydro-1H-spiro[imidazolidine-4,1'-inden]-1-yl]-N-[(2S)-1,1,1-trifluoro-2-propanyl]acetamide. Grade: ≥95%. CAS No. 1889284-33-6. Molecular formula: C29H27F5N6O4. Mole weight: 618.55. | |
| CBP/p300-IN-8 | CBP/p300-IN-8, a potent inhibitor of the CBP/P300 family of bromodomains, inhibits CBP and BRD4 activity with IC50s of 0.01-0.1 μM and 1-1000 μM, respectively. Synonyms: 6H-Imidazo[4,5-f]quinoline-6-carboxylic acid, 3-[(1S,3S)-3-carboxycyclohexyl]-3,7,8,9-tetrahydro-7-methyl-2-(phenylmethyl)-, 6-methyl ester, (7S)-; NSC-828853; (1S,3S)-3-[(7S)-2-Benzyl-6-(methoxycarbonyl)-7-methyl-6,7,8,9-tetrahydro-3H-imidazo[4,5-f]quinolin-3-yl]cyclohexanecarboxylic acid. Grade: ≥95%. CAS No. 2304416-91-7. Molecular formula: C27H31N3O4. Mole weight: 461.55. | |
| CBP/p300 ligand 2 | CBP/p300 ligand 2 is a ligand for target protein for PROTAC of dCBP-1. dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2484741-78-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138539. | |
| CBP-V | CBP-V. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9,9'-([1,1'-Biphenyl]-4,4'-diyl)bis(3-ethenyl-9H-carbazole). Product Category: Organic Light Emitting Diode (OLED). CAS No. 908147-48-8. Molecular formula: C40H28N2. Mole weight: 536.66 g/mol. Product ID: ACM908147488. Alfa Chemistry ISO 9001:2015 Certified. Categories: CBPV. | |
| CBR-470-1 | CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalent Nrf2 activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP+-induced cytotoxicity through activation of the Keap1-Nrf2 cascade[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2416095-06-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134205A. | |
| CBR-470-1 | CBR-470-1, a non-covalent Nrf2 activator, is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). It protects SH-SY5Y neuronal cells from MPP+ induced cytotoxicity by activating the Keap1-Nrf2 cascade. Synonyms: 3-Thiophenamine, 4-[(4-chlorophenyl)sulfonyl]tetrahydro-N-(2-methylpropyl)-, 1,1-dioxide, (3R,4S)-rel-; (3S,4R)-4-[(4-Chlorophenyl)sulfonyl]-N-isobutyltetrahydro-3-thiophenamine 1,1-dioxide; (3S,4R)-4-[(4-chlorophenyl)sulfonyl]-3-[(2-methylpropyl)amino]thiolane-1,1-dione. Grade: ≥98%. CAS No. 2416095-06-0. Molecular formula: C14H20ClNO4S2. Mole weight: 365.90. | |
| CBR-470-2 | CBR-470-2, an analogue of glycine substitution, activates NRF2 signaling and can be used to study modulation glycolysis. Synonyms: N-{(3S,4R)-4-[(3,4-Dichlorophenyl)sulfonyl]-1,1-dioxidotetrahydro-3-thiophenyl}glycine; Glycine, N-[(3R,4S)-4-[(3,4-dichlorophenyl)sulfonyl]tetrahydro-1,1-dioxido-3-thienyl]-, rel-. Grade: ≥95%. CAS No. 2416095-00-4. Molecular formula: C12H13Cl2NO6S2. Mole weight: 402.27. | |
| CBR 5884 | CBR 5884 is a 3-Phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50 = 33 μM), does not affect other NAD+-dependent dehydrogenases. Uses: 3-phosphoglycerate dehydrogenase (phgdh) inhibitor. Synonyms: CBR-5884; CBR 5884; CBR5884. Ethyl 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylate. Grade: ≥98%. CAS No. 681159-27-3. Molecular formula: C14H12N2O4S2. Mole weight: 336.39. | |
| CBR-5884 | CBR-5884 is an active, selective inhibitor of phosphoglycerate dehydrogenase (PHGDH) with an IC50 of 33 ?M. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 681159-27-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100012. | |
| CBR-5884 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| CBS1117 | CBS1117 is an effective inhibitor of influenza A virus entry, which can inhibit influenza virus hemagglutinin. Synonyms: 2,6-Dichloro-N-[1-(Propan-2-Yl)Piperidin-4-Yl]Benzamide. Grade: 98%. CAS No. 959245-08-0. Molecular formula: C15H20Cl2N2O. Mole weight: 315.2. | |
| CBS9106 | CBS9106, also known as BMS-566419, is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity. CRM1 plays an important role in the nuclear export of cargo proteins bearing nuclear exporting signal sequences. CBS9106 inhibits CRM1-dependent nuclear export, causing arrest of the cell cycle and inducing apoptosis in a time- and dose-dependent manner for a broad spectrum of cancer cells, including multiple myeloma cells. CBS9106 reduces CRM1 protein levels significantly without affecting CRM1 mRNA expression. Oral administration of CBS9106 significantly suppresses tumor growth and prolongs survival in mice bearing tumor xenograft without a significant loss in body weight. A reduced level of CRM1 protein is also observed in tumor xenografts isolated from mice treated with CBS9106. Taken together, these results indicate that CBS9106 is a novel reversible CRM1 inhibitor and a promising clinical candidate. Synonyms: SL-801; SL801; SL 801; CBS-9106; CBS 9106; BMS-566419; BMS566419; BMS 566419; 1H-Pyrrole-2,5-dione, 1-[[6-chloro-5-(trifluoromethyl)-2-pyridinyl]amino]-3-[(3,3-dimethylbutoxy)methyl]-4-methyl-. Grade: 98%. CAS No. 1076235-04-5. Molecular formula: C18H21ClF3N3O3. Mole weight: 419.83. | |
| CBS, N-Cyclohexyl -2-benzothiazolesulfenami de | CBS, N-Cyclohexyl -2-benzothiazolesulfenami de . Group: Biochemicals. Grades: Highly Purified. CAS No. 95-33-0. Pack Sizes: 250g, 500g. US Biological Life Sciences. | Worldwide |
| CBT-161 | CBT-161 is an ADC that STI-A0602, the monoclonal antibody targeting c-Met, links tubulin inhibitors or DNA damaging agents via C-lock. Preclinical study showed that CBT-161 significantly inhibited tumor growth. Uses: Antitumor drug. Synonyms: Anti-cMET ADC. | |
| c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-Agm | c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-Agm is an effective and selective short-acting peptide V2 receptor (V2R) agonist. Synonyms: D-Argininamide, 4-chloro-N-(4-mercapto-1-oxobutyl)-L-phenylalanyl-3-(2-thienyl)-L-alanyl-L-valyl-L-asparaginyl-L-cysteinyl-L-prolyl-N,N-diethyl-, cyclic (1→5)-thioether. CAS No. 1647119-71-8. Molecular formula: C47H69ClN12O9S2. Mole weight: 1045.71. | |
| c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2 | c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2 is an effective and selective short-acting peptide V2 receptor (V2R) agonist. Synonyms: Velmupressin; L-Prolinamide, 4-chloro-N-(4-mercapto-1-oxobutyl)-L-phenylalanyl-3-(2-thienyl)-L-alanyl-L-valyl-L-asparaginyl-L-cysteinyl-N-(4-((aminoiminomethyl)amino)butyl)-, cyclic (1->5)-thioether. Grade: ≥98%. CAS No. 1647119-61-6. Molecular formula: C42H60ClN11O8S2. Mole weight: 946.58. | |
| c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2 acetate | It is a potent, selective and short-acting peptide V2 receptor (V2R) agonist. Synonyms: 1-{[(3R,6S,9S,12S,15S)-6-(2-Amino-2-oxoethyl)-15-(4-chlorobenzyl)-9-isopropyl-5,8,11,14,17-pentaoxo-12-(2-thienylmethyl)-1-thia-4,7,10,13,16-pentaazacycloicosan-3-yl]carbonyl}-N-(4-carbamimidamidobutyl)-L-prolinamide acetate (1:1). Grade: ≥98%. CAS No. 1647120-04-4. Molecular formula: C44H64ClN11O10S2. Mole weight: 1006.63. | |
| Cbz-1-amino-1-cyclooctanecarboxylic acid | Cbz-1-amino-1-cyclooctanecarboxylic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CBZ-1-AMINO-1-CYCLOOCTANECARBOXYLIC ACID. Product Category: Heterocyclic Organic Compound. CAS No. 175407-63-3. Molecular formula: C17H23NO4. Mole weight: 305.37. Purity: 0.96. IUPACName: 1-(phenylmethoxycarbonylamino)cyclooctane-1-carboxylate. Canonical SMILES: C1CCCC(CCC1)(C(=O)O)NC(=O)OCC2=CC=CC=C2. Product ID: ACM175407633. Alfa Chemistry ISO 9001:2015 Certified. | |
| CBZ-8-amino-3,6-dioxaoctanoic acid | CBZ-8-amino-3,6-dioxaoctanoic acid. Group: Polymers. CAS No. 16545-06-8. |  |
| CBZ-9-amino-4,7-dioxanonanoic acid | CBZ-9-amino-4,7-dioxanonanoic acid. Group: Polymers. CAS No. 462100-05-6. | |
| Cbz-Aib-Leu-OMe | Cbz-Aib-Leu-OMe is a protected dipeptide used in peptide synthesis. The Cbz (Carbobenzyloxy) group protects the N-terminus of the α-aminoisobutyric acid (Aib) residue, preventing unwanted reactions during synthesis. Aib is a non-natural amino acid that induces helical structures in peptides due to its steric properties. Leu (Leucine) is the second amino acid in the sequence, known for its hydrophobic character, contributing to the overall structure and stability of the peptide. The OMe (methyl ester) group at the C-terminus indicates that the carboxyl group is esterified, which can be useful in strategies where further peptide extension or specific cleavage is required. This compound is employed to introduce both structural constraints and hydrophobic properties into peptides, enhancing their desired functional characteristics. Synonyms: N-Benzoxycarbonyl-alpha-methyl-alanyl-L-leucine methyl ester; Methyl (2-(((benzyloxy)carbonyl)amino)-2-methylpropanoyl)-L-leucinate; Z-Aib-Leu-OMe; L-Leucine, 2-methyl-N-[(phenylmethoxy)carbonyl]alanyl-, methyl ester; 2-Methyl-N-[(phenylmethoxy)carbonyl]alanyl-L-leucine methyl ester. Grade: ≥95%. CAS No. 866919-63-3. Molecular formula: C19H28N2O5. Mole weight: 364.44. | |
| Cbz-allo-thr(tbu)-oh·dcha | Cbz-allo-thr(tbu)-oh·dcha. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 198828-94-3, Z-Allo-thr(tbu)-oh dcha, MolPort-020-004-628, AKOS015911533, AK105242, B-7696, I14-37239, Dicyclohexylamine (2S,3S)-2-(((benzyloxy)carbonyl)amino)-3-(tert-butoxy)butanoate. Product Category: Heterocyclic Organic Compound. CAS No. 198828-94-3. Molecular formula: C28H46N2O5. Mole weight: 490.68. Purity: 0.96. IUPACName: N-cyclohexylcyclohexanamine;(2S,3S)-3-[(2-methylpropan-2-yl)oxy]-2-(phenylmethoxycarbonylamino)butanoic acid. Product ID: ACM198828943. Alfa Chemistry ISO 9001:2015 Certified. | |
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