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| Product | Description | |
|---|---|---|
| CBF? Activator, Kartogenin | The CBF? Activator, Kartogenin modulates the biological activity of CBF?. This small molecule/inhibitor is primarily used for Biochemicals applications. Group: Fluorescence/luminescence spectroscopy. |  |
| CBFβ Inhibitor | Core binding factors (CBFs) are heterodimeric transcription factors containing a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBFβ Inhibitor cellular studies indicate a good correlation between the inhibitor's antiproliferative activity and the Runx1 expression level in the target cells. Synonyms: Core Binding Factor-β Inhibitor; 2-Thiazolamine, 5-ethyl-4-(4-methoxyphenyl)-; 5-Ethyl-4-(4-methoxyphenyl)-2-thiazolamine; Sc 221405; 5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine. Grade: ≥98%. CAS No. 493028-20-9. Molecular formula: C12H14N2OS. Mole weight: 234.32. |  |
| CBF beta-Runx1 Inhibitor II, Ro5-3335 ([7-chloro-5-(2-pyrryl)-3H-1,4 benzodiazapin-2-(H)-one], Ro53335, CBFalpha-CBFbeta Inhibitor II) | A cell-permeable benzodiazepine that suppresses CBFalpha/Runx1-CBFbeta transactivation activity (25uM; 293-0 cells) via direct bindings to both subunits of the heterodimeric transcription factor complex. Shown to inhibit oncogenic fusion CBFB-MYH11-, TEL-RUNX1-, and RUNX1-ETO-, dependent leukemia cells proliferation (IC50 = 1.1 to 21.7uM) in vitro and more effectively reduce peripheral blood c-kit+ population (300mg/kg/d via animal feed) than Cytarabine in a murine Cbfb-MYH11 leukemia model in vivo. Comparing to CBFbeta-Runx1 Inhibitor I, Ro5-3335 modulates the Runx1-CBFbeta heterodimer formation without completely disrupting the subunits interaction. Group: Biochemicals. Grades: Highly Purified. CAS No. 30195-30-3. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| CBHA | Histone deacetylase (HDAC) inhibitors hyperacetylate histones and increase transcriptional activity in selected genes. CBHA is a cell-permeable second generation hybrid polar agent that acts as a HDAC inhibitor. It exhibits ID50 values of 0.01 and 0.07 μM in vitro for HDAC1 and HDAC3, respectively. CBHA also induces apoptosis in nine different neuroblastoma cell lines in culture. Uses: Histone deacetylase inhibitors. Synonyms: Histone Deacetylase Inhibitor II; m-Carboxycinnamic acid bis-hydroxamide. Grade: ≥98%. CAS No. 174664-65-4. Molecular formula: C10H10N2O4. Mole weight: 222.2. | |
| Cbi-bb zero/001606 | Cbi-bb zero/001606. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CBI-BB ZERO/001606;TIMTEC-BB SBB001518;4,6-DIMETHYL-1,2,4-TRIAZOLO[1,5-A]PYRIMIDINE-2-SULPHONYL CHLORIDE;5,7-DIMETHYL-1,2,4-TRIAZOLO [1,5A] PYRIMIDINE SULPHONYL CHLORIDE. Product Category: Heterocyclic Organic Compound. CAS No. 98169-74-5. Molecular formula: C7H7ClN4O2S. Mole weight: 246.67. Product ID: ACM98169745. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Cbi-bb zero/006283 | Cbi-bb zero/006283. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CHEMBRDG-BB 9071636;CBI-BB ZERO/006283;2-HYDROXY-3-(2-METHYLPHENOXY)PROPANOIC ACID;PROPANOIC ACID, 2-HYDROXY-3-(2-METHYLPHENOXY)-;TIMTEC-BB SBB014000. Product Category: Heterocyclic Organic Compound. CAS No. 26114-38-5. Molecular formula: C10H12O4. Mole weight: 196.2. Product ID: ACM26114385. Alfa Chemistry ISO 9001:2015 Certified. | |
| CBiPES hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| CBiPES hydrochloride | CBiPES hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 856702-40-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| CBiPES hydrochloride | CBiPES hydrochloride is a selective positive allosteric modulator of the mGlu2 receptor (IC50 = 98.2 nM). Synonyms: N-(4'-Cyano-[1,1'-biphenyl]-3-yl-N-(3-pyridinylmethyl)-ethanesulfonamide hydrochloride. Grade: ≥99% by HPLC. CAS No. 856702-40-4. Molecular formula: C21H19N3O2S.HCl. Mole weight: 413.92. | |
| CBIQ | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| CBL0137 | CBL0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 μM and inhibits NF-κB with an EC50 of 0.47 μM. It also inhibits histone chaperone FACT (facilitates chromatin transcription) and MYC signal. Synonyms: CBL0137; CBL-0137; CBL 0137; CBLC137; CBLC-137; CBLC 137; Curaxin 137; 1,1'-(9-(2-(Isopropylamino)ethyl)-9H-carbazole-3,6-diyl)diethanone; 1-[6-acetyl-9-[2-(propan-2-ylamino)ethyl]carbazol-3-yl]ethanone. CAS No. 1197996-80-7. Molecular formula: C21H24N2O2. Mole weight: 336.435. | |
| CBL0137 | CBL0137, a curaxin compound, is a histone chaperone facilitates chromatin transcription (FACT) inhibitor. CBL0137 downregulates NF- B and activates p53. CBL0137 restores both histone H3 acetylation and trimethylation. CBL0137 is an anticancer agent. CBL0137 induces cancer cell apoptosis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Curaxin 137; CBL-C137. CAS No. 1197996-80-7. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18935. |  |
| CBL0137 hydrochloride | CBL0137 hydrochloride is an inhibitor of the histone chaperone, FACT. CBL0137 hydrochloride can also activate p53 and inhibits NF-κB with EC 50 s of 0.37 and 0.47 μM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Curaxin-137 hydrochloride; CBL-C137 hydrochloride. CAS No. 1197397-89-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18935A. | |
| CBL0137 hydrochloride | NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. CBL0137 activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It functionally inactivates the facilitates chromatin transcription complex, driving the effects on p53 and NF-κB and promoting cancer cell death. Synonyms: CBLC137; CBL-0137; Curaxin 137. Grade: ≥98%. CAS No. 1197397-89-9. Molecular formula: C21H24N2O2·HCl. Mole weight: 372.9. | |
| Cbl-b-IN-1 | Cbl-b-IN-1 (Example 519) is an inhibitor of Cbl-b, with an IC50 of less than 100 nM. Cbl-b-IN-1 can promote the secretion of cytokines such as IL-2, IFN-?, and TNF-?, facilitate T cell activation, and enhance the TCR signaling pathway. Cbl-b-IN-1 can be used in research on immunomodulation[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2368841-84-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136339. | |
| Cbl-b-IN-3 | Cbl-b-IN-3 inhibits proto-oncogene-B (CPL-B). CBL-B is an E3 ubiquitin ligase that ubiquitinates proteins downstream of immune receptors to downregulate positive signaling cascades. Synonyms: 2-{3-[(1S,3R)-3-methyl-1-(4-methyl-4H-1,2,4-triazol-3-yl)cyclobutyl]phenyl}-6-{[(3S)-3-methylpiperidin-1-yl]methyl}-4-(trifluoromethyl)-2,3-dihydro-1H-isoindol-1-one. Grade: >98.0%. CAS No. 2573775-59-2. Molecular formula: C30H34F3N5O. Mole weight: 537.63. | |
| CBLC000 trifluoroacetate | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| CBM 301940 | Malonyl-CoA decarboxylase (MCD) is found from bacteria to humans, which has important roles in regulating fatty acid metabolism and food intake. CBM 301940 is a potent malonyl-CoA decarboxylase (MCD) inhibitor with IC50 of 23 nM. It suppresses malonyl-CoA degradation and fatty acid oxidation in isolated rat hearts, leading to secondary increase in glucose oxidation. Synonyms: (2S,3R,4S)-3-ethenyl-2-(beta-D-glucopyranosyloxy)-3,4-dihydro-4-(2-oxoethyl)-2H-pyran-5-carboxylic acid, methyl ester; CBM301940; CBM-301940. Grade: ≥98%. CAS No. 902146-11-6. Molecular formula: C15H20F6N2O5. Mole weight: 422.32. | |
| CBP | CBP. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4,4'-Bis(carbazol-9-yl)biphenyl. Product Category: Organic Light Emitting Diode (OLED). CAS No. 58328-31-7. Molecular formula: C36H24N2. Mole weight: 484.59 g/mol. Purity: 95%+. IUPACName: 9-[4-(4-carbazol-9-ylphenyl)phenyl]carbazole. Canonical SMILES: C1=CC=C2C(=C1)C3=CC=CC=C3N2C4=CC=C(C=C4)C5=CC=C(C=C5)N6C7=CC=CC=C7C8=CC=CC=C86. Density: 1.19 g/ml. Product ID: ACM58328317. Alfa Chemistry ISO 9001:2015 Certified. | |
| CBP (1319-1710), GST tagged human | recombinant, expressed in E. coli, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| CBP501 | CBP501 is a peptide with G2 checkpoint-abrogating activity. G2 checkpoint inhibitor CBP501 inhibits multiple serine/threonine kinases, including MAPKAP-K2, C-Tak1, and CHK1, that phosphorylate serine 216 of the dual-specific phosphatase Cdc25C (cell division checkpoint 25 C); disruption of Cdc25C activity results in the inhibition of Cdc25C dephosphorylation of the mitotic cyclin-dependent kinase complex Cdc2/cyclin B, preventing entry into the mitotic phase of the cell cycle. Check for active clinical trials or closed clinical trials using this agent. Synonyms: CBP-501; CBP 501; H-D-Bpa-D-Ser-D-Trp-D-Ser-D-Phe(F5)-D-Cha-D-Arg-D-Arg-D-Arg-D-Gln-D-Arg-D-Arg-OH. CAS No. 565434-85-7. Molecular formula: C86H122F5N29O17. Mole weight: 1929.06. | |
| CBP501 Affinity Peptide | CBP501 Affinity Peptide exhibits similarity to part of the human 14-3-3e αC helix, suggesting that CBP501 may bind to this region. Synonyms: H-Asn-Ser-Asp-Cys-Ile-Ile-Ser-Arg-Lys-Ile-Glu-Gln-Lys-Glu-OH; L-Glutamic acid, L-asparaginyl-L-seryl-L-α-aspartyl-L-cysteinyl-L-isoleucyl-L-isoleucyl-L-seryl-L-arginyl-L-lysyl-L-isoleucyl-L-α-glutamyl-L-glutaminyl-L-lysyl-. Grade: ≥95%. CAS No. 1351804-17-5. Molecular formula: C68H119N21O25S. Mole weight: 1662.89. | |
| CBP-93872 | CBP-93872 is a G2 checkpoint inhibitor. CBP-93872 specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint through inhibiting maintenance. CBP-93872 is an inhibitor of maintenance of the DSB-specific G2 checkpoint and thus might be a strong candidate as the basis for a drug that specifically sensitizes p53-mutated cancer cells to DSB-inducing DNA damage therapy. Synonyms: CBP 93872; CBP93872; 1-amino-3-((2-bromo-4-methylphenyl)amino)propan-2-ol. Grade: 98%. CAS No. 67427-51-4. Molecular formula: C10H15BrN2O. Mole weight: 259.14. | |
| CBP-aminomethylenevancomycin | CBP-aminomethylenevancomycin is an analogue of vancomycin which overcomes the drug resistance and induces cell permeability. It significantly increases the antibacterial activity and decreases the side effects. Uses: Antibacterial agent. Synonyms: CBP aminomethylenevancomycin. | |
| CBP-C1-aminomethylenevancomycin | CBP-C1-aminomethylenevancomycin is an analogue of vancomycin which overcomes the drug resistance and induces cell permeability. It significantly increases the antibacterial activity and decreases the side effects. Uses: Antibacterial agent. Synonyms: CBP C1 aminomethylenevancomycin. | |
| CBPD-409 | CBPD-409 is an orally active PROTAC degrader for CBP/p300, with DC50 of 0.2-0.4 nM. CBPD-409 exhibits antiproliferative effects in AR+ prostate cancer cell lines VCaP, LNCaP and 22Rv1, with IC50s of 1.2-2.0 nM. CBPD-409 exhibits antitumor efficacy (Red: CBP inhibitor GNE049 (HY-108435); Blue: CRBN/cullin 4A Thalidomide (HY-14658); Black: Linker)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3037549-86-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-158113. | |
| CBP/EP300-IN-2 | CBP/EP300-IN-2 is a CBP/EP300 inhibitor with IC50s of 1.07 and 5.96 nM for CBP/HTRF and Myc, respectively. (Extracted from patent WO2017205538A1, example 25). Synonyms: 5H-Pyrazolo[4,3-c]pyridine-5-carboxamide, 3-[6-(difluoromethyl)-7-(1-methyl-1H-pyrazol-4-yl)-4-isoquinolinyl]-1,4,6,7-tetrahydro-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-; CBP/p300-IN-2; 3-[6-(Difluoromethyl)-7-(1-methyl-1H-pyrazol-4-yl)-4-isoquinolinyl]-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide. Grade: ≥95%. CAS No. 2158265-96-2. Molecular formula: C27H29F2N7O2. Mole weight: 521.56. | |
| CBP-iminomethylenevancomycin | CBP-iminomethylenevancomycin is an analogue of vancomycin which overcomes the drug resistance and induces cell permeability. It significantly increases the antibacterial activity and decreases the side effects. Uses: Antibacterial agent. Synonyms: CBP iminomethylenevancomycin. | |
| CBP/p300-IN-1 | CBP/p300-IN-1 is an inhibitor of CBP/EP300 bromodomain. Synonyms: 2-Methyl-2-propanyl 3-{[(1-acetyl-5-methoxy-1H-indol-3-yl)carbonyl]amino}-4-fluorobenzoate; tert-Butyl 3-(1-acetyl-5-methoxy-1H-indole-3-carboxamido)-4-fluorobenzoate; Benzoic acid, 3-[[(1-acetyl-5-methoxy-1H-indol-3-yl)carbonyl]amino]-4-fluoro-, 1,1-dimethylethyl ester. Grade: ≥95%. CAS No. 2443789-32-8. Molecular formula: C23H23FN2O5. Mole weight: 426.44. | |
| CBP/p300-IN-12 | CBP/p300-IN-12 is a potent and selective covalent histone acetyltransferases p300 (IC50 = 166 nM) and CBP inhibitor that reduces H3K27Ac levels in PC-3 cells (EC50 = 37 nM). CBP/p300-IN-12 forms a covalent adduct with C1450. Synonyms: N-(3-(3-((R)-3'-(2-((4-fluorobenzyl)((S)-1,1,1-trifluoropropan-2-yl)amino)-2-oxoethyl)-2',4'-dioxo-2,3-dihydrospiro[indene-1,5'-oxazolidin]-5-yl)ureido)phenyl)acrylamide. Molecular formula: C33H29F4N5O6. Mole weight: 667.61. | |
| CBP/p300-IN-14 | CBP/p300-IN-14 is a potent CBP/EP300 (lysine acetyltransferase) inhibitor with an IC50 of 3.3 nM. (Extracted from patent WO2021213521A1, compound 27). Synonyms: 3-Isoquinolinecarboxamide, 1-[7-(difluoromethyl)-3,4-dihydro-6-(1-methyl-1H-pyrazol-4-yl)-1(2H)-quinolinyl]-N-methyl-6-(4-methyl-2-oxo-1-piperazinyl)-; 1-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-methyl-6-(4-methyl-2-oxopiperazin-1-yl)isoquinoline-3-carboxamide. CAS No. 2725036-10-0. Molecular formula: C30H31F2N7O2. Mole weight: 559.61. | |
| CBP/p300-IN-19 hydrochloride | CBP/p300-IN-19 hydrochloride is a potent and selective p300/CBP HAT inhibitor with IC 50 s of 1.4, 2.2, >100, >100 μM for p300-HAT, CBP-HAT, PCAF, Myst3, respectively. CBP/p300-IN-19 hydrochloride shows antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2592638-14-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-146277A. | |
| CBP/p300-IN-5 | P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase with an IC50 of 18.8 nM. (Extracted from patent WO2016044770A1, Example 715). Synonyms: CBP/p300-IN-5; 2-[4-[(3'R,4S)-3'-fluoro-1-[2-[(4-fluorophenyl)methyl-[(1S)-2,2,2-trifluoro-1-methyl-ethyl]amino]-2-oxo-ethyl]-2,5-dioxo-spiro[imidazolidine-4,1'-indane]-5'-yl]pyrazol-1-yl]-N-methylacetamide; 2-((3'R,4S)-3'-Fluoro-5'-(1-(2-(methylamino)-2-oxoethyl)-1H-pyrazol-4-yl)-2,5-dioxo-2',3'-dihydrospiro[imidazolidine-4,1'-inden]-1-yl)-N-(4-fluorobenzyl)-N-((S)-1,1,1-trifluoropropan-2-yl)acetamide; N-(4-Fluorobenzyl)-2-[(3'R,4S)-3'-fluoro-5'-{1-[2-(methylamino)-2-oxoethyl]-1H-pyrazol-4-yl}-2,5-dioxo-2',3'-dihydro-1H-spiro[imidazolidine-4,1'-inden]-1-yl]-N-[(2S)-1,1,1-trifluoro-2-propanyl]acetamide. Grade: ≥95%. CAS No. 1889284-33-6. Molecular formula: C29H27F5N6O4. Mole weight: 618.55. | |
| CBP/p300-IN-8 | CBP/p300-IN-8, a potent inhibitor of the CBP/P300 family of bromodomains, inhibits CBP and BRD4 activity with IC50s of 0.01-0.1 μM and 1-1000 μM, respectively. Synonyms: 6H-Imidazo[4,5-f]quinoline-6-carboxylic acid, 3-[(1S,3S)-3-carboxycyclohexyl]-3,7,8,9-tetrahydro-7-methyl-2-(phenylmethyl)-, 6-methyl ester, (7S)-; NSC-828853; (1S,3S)-3-[(7S)-2-Benzyl-6-(methoxycarbonyl)-7-methyl-6,7,8,9-tetrahydro-3H-imidazo[4,5-f]quinolin-3-yl]cyclohexanecarboxylic acid. Grade: ≥95%. CAS No. 2304416-91-7. Molecular formula: C27H31N3O4. Mole weight: 461.55. | |
| CBP/p300 ligand 2 | CBP/p300 ligand 2 is a ligand for target protein for PROTAC of dCBP-1. dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2484741-78-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138539. | |
| CBP-V | CBP-V. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9,9'-([1,1'-Biphenyl]-4,4'-diyl)bis(3-ethenyl-9H-carbazole). Product Category: Organic Light Emitting Diode (OLED). CAS No. 908147-48-8. Molecular formula: C40H28N2. Mole weight: 536.66 g/mol. Product ID: ACM908147488. Alfa Chemistry ISO 9001:2015 Certified. Categories: CBPV. | |
| CBR-470-1 | CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalent Nrf2 activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP+-induced cytotoxicity through activation of the Keap1-Nrf2 cascade[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2416095-06-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134205A. | |
| CBR-470-1 | CBR-470-1, a non-covalent Nrf2 activator, is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). It protects SH-SY5Y neuronal cells from MPP+ induced cytotoxicity by activating the Keap1-Nrf2 cascade. Synonyms: 3-Thiophenamine, 4-[(4-chlorophenyl)sulfonyl]tetrahydro-N-(2-methylpropyl)-, 1,1-dioxide, (3R,4S)-rel-; (3S,4R)-4-[(4-Chlorophenyl)sulfonyl]-N-isobutyltetrahydro-3-thiophenamine 1,1-dioxide; (3S,4R)-4-[(4-chlorophenyl)sulfonyl]-3-[(2-methylpropyl)amino]thiolane-1,1-dione. Grade: ≥98%. CAS No. 2416095-06-0. Molecular formula: C14H20ClNO4S2. Mole weight: 365.90. | |
| CBR-470-2 | CBR-470-2, an analogue of glycine substitution, activates NRF2 signaling and can be used to study modulation glycolysis. Synonyms: N-{(3S,4R)-4-[(3,4-Dichlorophenyl)sulfonyl]-1,1-dioxidotetrahydro-3-thiophenyl}glycine; Glycine, N-[(3R,4S)-4-[(3,4-dichlorophenyl)sulfonyl]tetrahydro-1,1-dioxido-3-thienyl]-, rel-. Grade: ≥95%. CAS No. 2416095-00-4. Molecular formula: C12H13Cl2NO6S2. Mole weight: 402.27. | |
| CBR 5884 | CBR 5884 is a 3-Phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50 = 33 μM), does not affect other NAD+-dependent dehydrogenases. Uses: 3-phosphoglycerate dehydrogenase (phgdh) inhibitor. Synonyms: CBR-5884; CBR 5884; CBR5884. Ethyl 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylate. Grade: ≥98%. CAS No. 681159-27-3. Molecular formula: C14H12N2O4S2. Mole weight: 336.39. | |
| CBR-5884 | CBR-5884 is an active, selective inhibitor of phosphoglycerate dehydrogenase (PHGDH) with an IC50 of 33 ?M. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 681159-27-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100012. | |
| CBR-5884 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| CBS1117 | CBS1117 is an effective inhibitor of influenza A virus entry, which can inhibit influenza virus hemagglutinin. Synonyms: 2,6-Dichloro-N-[1-(Propan-2-Yl)Piperidin-4-Yl]Benzamide. Grade: 98%. CAS No. 959245-08-0. Molecular formula: C15H20Cl2N2O. Mole weight: 315.2. | |
| CBS9106 | CBS9106, also known as BMS-566419, is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity. CRM1 plays an important role in the nuclear export of cargo proteins bearing nuclear exporting signal sequences. CBS9106 inhibits CRM1-dependent nuclear export, causing arrest of the cell cycle and inducing apoptosis in a time- and dose-dependent manner for a broad spectrum of cancer cells, including multiple myeloma cells. CBS9106 reduces CRM1 protein levels significantly without affecting CRM1 mRNA expression. Oral administration of CBS9106 significantly suppresses tumor growth and prolongs survival in mice bearing tumor xenograft without a significant loss in body weight. A reduced level of CRM1 protein is also observed in tumor xenografts isolated from mice treated with CBS9106. Taken together, these results indicate that CBS9106 is a novel reversible CRM1 inhibitor and a promising clinical candidate. Synonyms: SL-801; SL801; SL 801; CBS-9106; CBS 9106; BMS-566419; BMS566419; BMS 566419; 1H-Pyrrole-2,5-dione, 1-[[6-chloro-5-(trifluoromethyl)-2-pyridinyl]amino]-3-[(3,3-dimethylbutoxy)methyl]-4-methyl-. Grade: 98%. CAS No. 1076235-04-5. Molecular formula: C18H21ClF3N3O3. Mole weight: 419.83. | |
| CBS, N-Cyclohexyl -2-benzothiazolesulfenami de | CBS, N-Cyclohexyl -2-benzothiazolesulfenami de . Group: Biochemicals. Grades: Highly Purified. CAS No. 95-33-0. Pack Sizes: 250g, 500g. US Biological Life Sciences. | Worldwide |
| CBT-161 | CBT-161 is an ADC that STI-A0602, the monoclonal antibody targeting c-Met, links tubulin inhibitors or DNA damaging agents via C-lock. Preclinical study showed that CBT-161 significantly inhibited tumor growth. Uses: Antitumor drug. Synonyms: Anti-cMET ADC. | |
| c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-Agm | c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-Agm is an effective and selective short-acting peptide V2 receptor (V2R) agonist. Synonyms: D-Argininamide, 4-chloro-N-(4-mercapto-1-oxobutyl)-L-phenylalanyl-3-(2-thienyl)-L-alanyl-L-valyl-L-asparaginyl-L-cysteinyl-L-prolyl-N,N-diethyl-, cyclic (1→5)-thioether. CAS No. 1647119-71-8. Molecular formula: C47H69ClN12O9S2. Mole weight: 1045.71. | |
| c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2 | c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2 is an effective and selective short-acting peptide V2 receptor (V2R) agonist. Synonyms: Velmupressin; L-Prolinamide, 4-chloro-N-(4-mercapto-1-oxobutyl)-L-phenylalanyl-3-(2-thienyl)-L-alanyl-L-valyl-L-asparaginyl-L-cysteinyl-N-(4-((aminoiminomethyl)amino)butyl)-, cyclic (1->5)-thioether. Grade: ≥98%. CAS No. 1647119-61-6. Molecular formula: C42H60ClN11O8S2. Mole weight: 946.58. | |
| c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2 acetate | It is a potent, selective and short-acting peptide V2 receptor (V2R) agonist. Synonyms: 1-{[(3R,6S,9S,12S,15S)-6-(2-Amino-2-oxoethyl)-15-(4-chlorobenzyl)-9-isopropyl-5,8,11,14,17-pentaoxo-12-(2-thienylmethyl)-1-thia-4,7,10,13,16-pentaazacycloicosan-3-yl]carbonyl}-N-(4-carbamimidamidobutyl)-L-prolinamide acetate (1:1). Grade: ≥98%. CAS No. 1647120-04-4. Molecular formula: C44H64ClN11O10S2. Mole weight: 1006.63. | |
| Cbz-1-amino-1-cyclooctanecarboxylic acid | Cbz-1-amino-1-cyclooctanecarboxylic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CBZ-1-AMINO-1-CYCLOOCTANECARBOXYLIC ACID. Product Category: Heterocyclic Organic Compound. CAS No. 175407-63-3. Molecular formula: C17H23NO4. Mole weight: 305.37. Purity: 0.96. IUPACName: 1-(phenylmethoxycarbonylamino)cyclooctane-1-carboxylate. Canonical SMILES: C1CCCC(CCC1)(C(=O)O)NC(=O)OCC2=CC=CC=C2. Product ID: ACM175407633. Alfa Chemistry ISO 9001:2015 Certified. | |
| CBZ-8-amino-3,6-dioxaoctanoic acid | CBZ-8-amino-3,6-dioxaoctanoic acid. Group: Polymers. CAS No. 16545-06-8. |  |
| CBZ-9-amino-4,7-dioxanonanoic acid | CBZ-9-amino-4,7-dioxanonanoic acid. Group: Polymers. CAS No. 462100-05-6. | |
| Cbz-Aib-Leu-OMe | Cbz-Aib-Leu-OMe is a protected dipeptide used in peptide synthesis. The Cbz (Carbobenzyloxy) group protects the N-terminus of the α-aminoisobutyric acid (Aib) residue, preventing unwanted reactions during synthesis. Aib is a non-natural amino acid that induces helical structures in peptides due to its steric properties. Leu (Leucine) is the second amino acid in the sequence, known for its hydrophobic character, contributing to the overall structure and stability of the peptide. The OMe (methyl ester) group at the C-terminus indicates that the carboxyl group is esterified, which can be useful in strategies where further peptide extension or specific cleavage is required. This compound is employed to introduce both structural constraints and hydrophobic properties into peptides, enhancing their desired functional characteristics. Synonyms: N-Benzoxycarbonyl-alpha-methyl-alanyl-L-leucine methyl ester; Methyl (2-(((benzyloxy)carbonyl)amino)-2-methylpropanoyl)-L-leucinate; Z-Aib-Leu-OMe; L-Leucine, 2-methyl-N-[(phenylmethoxy)carbonyl]alanyl-, methyl ester; 2-Methyl-N-[(phenylmethoxy)carbonyl]alanyl-L-leucine methyl ester. Grade: ≥95%. CAS No. 866919-63-3. Molecular formula: C19H28N2O5. Mole weight: 364.44. | |
| Cbz-allo-thr(tbu)-oh·dcha | Cbz-allo-thr(tbu)-oh·dcha. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 198828-94-3, Z-Allo-thr(tbu)-oh dcha, MolPort-020-004-628, AKOS015911533, AK105242, B-7696, I14-37239, Dicyclohexylamine (2S,3S)-2-(((benzyloxy)carbonyl)amino)-3-(tert-butoxy)butanoate. Product Category: Heterocyclic Organic Compound. CAS No. 198828-94-3. Molecular formula: C28H46N2O5. Mole weight: 490.68. Purity: 0.96. IUPACName: N-cyclohexylcyclohexanamine;(2S,3S)-3-[(2-methylpropan-2-yl)oxy]-2-(phenylmethoxycarbonylamino)butanoic acid. Product ID: ACM198828943. Alfa Chemistry ISO 9001:2015 Certified. | |
| Cbz-Asp(OtBu)-Phe-Glu(OtBu)-Glu(OtBu)-Ile-Pro-OH | Cbz-Asp(OtBu)-Phe-Glu(OtBu)-Glu(OtBu)-Ile-Pro-OH is a protected hexapeptide used in peptide synthesis. It consists of aspartic acid (Asp), phenylalanine (Phe), glutamic acid (Glu), isoleucine (Ile), and proline (Pro). The Cbz (Carbobenzyloxy) group protects the N-terminus of aspartic acid, while the OtBu (tert-butyl) groups protect the hydroxyl groups of the glutamic acid residues. The remaining amino acids are in their free forms, with the C-terminus of the proline residue indicated by -OH, allowing for further coupling or modifications. This hexapeptide is designed for controlled reactivity and stability during peptide synthesis. Synonyms: Cbz-Asp(OtBu)-Phe-Glu(OtBu)-Glu(OtBu)-Ile-Pro; ((S)-2-((S)-2-((S)-2-((S)-2-(((Benzyloxy)carbonyl)amino)-4-(tert-butoxy)-4-oxobutanamido)-3-phenylpropanamido)-5-(tert-butoxy)-5-oxopentanamido)-5-(tert-butoxy)-5-oxopentanoyl)-L-isoleucyl-L-proline; Cbz-Asp(tBu)-Phe-Glu(tBu)-Glu(tBu)-Ile-Pro-OH. Grade: ≥90%. Molecular formula: C54H78N6O15. Mole weight: 1051.25. | |
| Cbz-Asp(OtBu)-Phe-Glu(OtBu)-OH | Cbz-Asp(OtBu)-Phe-Glu(OtBu)-OH is a protected tripeptide used in peptide synthesis. The Cbz (Carbobenzyloxy) group protects the N-terminus of the aspartic acid (Asp) residue, preventing it from reacting during synthesis. Both the aspartic acid and glutamic acid (Glu) residues have their side chain carboxyl groups protected by OtBu (tert-butyl) groups, ensuring these groups remain unreactive until selective deprotection is required. Phe (Phenylalanine) is the central amino acid in the sequence, contributing aromatic character. The -OH at the C-terminus indicates a free carboxyl group, allowing for further peptide coupling. This compound is used to introduce aspartic acid, phenylalanine, and glutamic acid into peptides with specific protections to control the reactivity and maintain the integrity of functional groups during synthesis. Synonyms: DFE; ((Benzyloxy)carbonyl)-O-(tert-butyl)-L-aspartyl-L-phenylalanyl-O-(tert-butyl)-L-glutamic acid; Z-Asp(OtBu)-Phe-Glu(OtBu)-OH. Grade: ≥95%. Molecular formula: C34H45N3O10. Mole weight: 655.75. | |
| Cbz-Asp(OtBu)-Phe-Glu(OtBu)-OMe | Cbz-Asp(OtBu)-Phe-Glu(OtBu)-OMe is a protected tripeptide used in peptide synthesis. The Cbz (Carbobenzyloxy) group protects the N-terminus of the aspartic acid (Asp) residue, preventing it from reacting during the synthesis process. Both the aspartic acid and glutamic acid (Glu) residues have their side chain carboxyl groups protected by OtBu (tert-butyl) groups, ensuring these groups remain unreactive until selective deprotection is required. Phe (Phenylalanine), the central amino acid in the sequence, adds hydrophobic and aromatic properties to the peptide. The OMe (methyl ester) at the C-terminus indicates that the carboxyl group of the glutamic acid is esterified, which can be useful for further synthetic modifications or coupling reactions. This compound is employed to introduce aspartic acid, phenylalanine, and glutamic acid into peptides, with controlled reactivity through specific protective groups. Synonyms: DFE; 5-(tert-Butyl) 1-methyl ((S)-2-(((benzyloxy)carbonyl)amino)-4-(tert-butoxy)-4-oxobutanoyl)-L-phenylalanyl-L-glutamate; Z-Asp(OtBu)-Phe-Glu(OtBu)-OMe. Grade: ≥95%. Molecular formula: C35H47N3O10. Mole weight: 669.77. | |
| Cbz-Asp(OtBu)-Tyr(OtBu)-Ser(OtBu)-OMe | Cbz-Asp(OtBu)-Tyr(OtBu)-Ser(OtBu)-OMe is a protected tripeptide used in peptide synthesis. The Cbz (Carbobenzyloxy) group protects the N-terminus of the aspartic acid (Asp) residue, preventing it from participating in unwanted reactions. The side chains of aspartic acid, tyrosine (Tyr), and serine (Ser) are each protected by OtBu (tert-butyl) groups, which shield their carboxyl and hydroxyl groups from reactivity until selective deprotection is desired. Tyr contributes aromatic and hydrophobic properties to the peptide, while Ser adds additional functionality. The OMe (methyl ester) at the C-terminus indicates that the carboxyl group of serine is esterified, which can facilitate further chemical modifications or reactions. This compound is used to incorporate aspartic acid, tyrosine, and serine into peptides, with specific protections to ensure controlled synthesis and reactivity of functional groups. Synonyms: DYS; Cbz-Asp(tBu)-Tyr(tBu)-Ser(tBu)-OMe; Z-Asp(OtBu)-Tyr(OtBu)-Ser(OtBu)-OMe; Methyl (5S,8S,11S)-5-(2-(tert-butoxy)-2-oxoethyl)-8-(4-(tert-butoxy)benzyl)-11-(tert-butoxymethyl)-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazadodecan-12-oate. Grade: ≥95%. Molecular formula: C37H53N3O10. Mole weight: 699.84. | |
| Cbz-B3A | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Cbz-b-Alanine | Cbz-b-Alanine. Group: Biochemicals. Grades: Highly Purified. CAS No. 2304-94-1. Pack Sizes: 50g, 100g, 250g, 500g. US Biological Life Sciences. | Worldwide |
| Cbz-beta-amino-L-alanine tert-butyl ester hydrochloride | Cbz-beta-amino-L-alanine tert-butyl ester hydrochloride. Uses: Designed for use in research and industrial production. Additional or Alternative Names: AKOS022181690, AK-62642, (S)-tert-Butyl 3-amino-2-(((benzyloxy)carbonyl)amino)propanoate hydrochloride, 174796-88-4. Product Category: Heterocyclic Organic Compound. CAS No. 174796-88-4. Molecular formula: C15H23ClN2O4. Mole weight: 330.807120 [g/mol]. Purity: 0.96. IUPACName: tert-butyl (2S)-3-amino-2-(phenylmethoxycarbonylamino)propanoate;hydrochloride. Product ID: ACM174796884. Alfa Chemistry ISO 9001:2015 Certified. Categories: H-L-Dap(Z)-OtBu HCl. | |
| Cbz-(boc)Lys-(boc)-lys-(boc)-lys-(boc)-lys-OH | Cbz-(boc)Lys-(boc)-lys-(boc)-lys-(boc)-lys-OH. Molecular formula: C52H88N8O15. Mole weight: 1065.32. | |
| Cbz-Cyclohexyl-L-glycine | A gylicine derivative used in the preparation of peptides as inhibitors of serine proteases, particularly hepatitis C virus NS3-NS4A protease. Group: Biochemicals. Alternative Names: (α S) -α - [ [ (Phenylmethoxy) carbonyl] amino] cyclohexaneacetic Acid; (S) -α - [ [ (phenylmethoxy) carbonyl] amino] cyclohexaneacetic Acid. Grades: Highly Purified. CAS No. 69901-75-3. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| Cbz-D-Ala-OMe | Cbz-D-Ala-OMe. Synonyms: methyl N-[(benzyloxy)carbonyl]alaninate; (S)-methyl 2-(benzyloxycarbonylamino)propanoate. CAS No. 64562-95-4. Molecular formula: C12H15NO4. Mole weight: 237.25. | |
| Cbz-D-Aze-OH | Cbz-D-Aze-OH. Synonyms: Z-D-Azetidine-2-Carboxylic acid; Cbz D Aze OH. CAS No. 25654-51-7. Molecular formula: C12H13NO4. Mole weight: 235.24. | |
| Cbz-D-(-)-Phenylglycine | Cbz-D-(-)-Phenylglycine. Group: Biochemicals. Grades: Highly Purified. CAS No. 17609-52-8. Pack Sizes: 5g, 10g, 25g. US Biological Life Sciences. | Worldwide |
| Cbz-D-Trp-OMe | Cbz-D-Trp-OMe. Synonyms: Z-D-Trp-OMe; D-Tryptophan, N-[(phenylmethoxy)carbonyl]-, methyl ester; (R)-Methyl 2-(((benzyloxy)carbonyl)amino)-3-(1H-indol-3-yl)propanoate; N-benzyloxycarbonyl-d-tryptophan methyl ester. CAS No. 130812-44-1. Molecular formula: C20H20N2O4. Mole weight: 352.38. | |
| Cbz-Glu(OtBu)-Ile-Pro-OMe | Cbz-Glu(OtBu)-Ile-Pro-OMe is a protected tripeptide used in peptide synthesis. The Cbz (Carbobenzyloxy) group protects the N-terminus of the glutamic acid (Glu) residue, preventing it from participating in unwanted reactions. The side chain of glutamic acid is further protected by an OtBu (tert-butyl) group, which shields the carboxyl group from reactivity until selective deprotection is required. Ile (Isoleucine), the middle amino acid in the sequence, adds hydrophobic properties, while Pro (Proline) is the third amino acid, known for inducing kinks in peptide chains due to its rigid cyclic structure. The OMe (methyl ester) at the C-terminus indicates that the carboxyl group of proline is esterified, which can be useful in controlling reactivity or further synthetic modifications. This compound is used to incorporate glutamic acid, isoleucine, and proline into peptides while maintaining precise control over the reactivity of the functional groups. Synonyms: EIP; Methyl ((S)-2-(((benzyloxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoyl)-L-isoleucyl-L-prolinate; Z-Glu(OtBu)-Ile-Pro-OMe. Grade: ≥95%. Molecular formula: C29H43N3O8. Mole weight: 561.68. | |
| Cbz-Glu-Trp-OH | Cbz-Glu-Trp-OH. Synonyms: Cbz Glu Trp OH; Z-Glu-Trp; (S)-4-(((benzyloxy)carbonyl)amino)-5-(((S)-1-carboxy-2-(1H-indol-3-yl)ethyl)amino)-5-oxopentanoic acid. CAS No. 73170-51-1. Molecular formula: C24H25N3O7. Mole weight: 467.47. | |
| Cbz-glycine | Cbz-glycine. Group: Biochemicals. Grades: Highly Purified. CAS No. 1138-80-3. Pack Sizes: 50g, 100g, 250g, 500g. US Biological Life Sciences. | Worldwide |
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