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The side-chain Trt group can be selectively removed with 1% TFA in DCM containing 5% TIS, enabling the side-chain hydroxyl group to be selectively modified whilst the derivative is attached to the solid support. This is an excellent derivative for synthesizing phosphothreonine-containing peptides and peptides modified at the threonine side-chain. The use of trityl-protected amino acids resulted in purer products than when standard t-Bu-protected amino acids were utilized. Uses: Fmoc solid-phase peptide synthesis. Additional or Alternative Names: Fmoc-Thr(Trt)-OH, N-α-Fmoc-O-trityl-L-threonine. Product Category: Amino Acids. CAS No. 133180-01-5. Molecular formula: C38H33NO5. Mole weight: 583.7. Product ID: ACM133180015. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Tic-OH
Standard building block for introduction of Tic amino-acid residues by Fmoc SPPS. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Tic-OH, N-1-Fmoc-L-1,2,3,4,-tetrahydro-isoquinoline-3-carboxylic acid. Product Category: Amino Acids. CAS No. 136030-33-6. Mole weight: 399.44. Product ID: ACM136030336. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-TOAC-OH is a useful tool for the incorporation of the ESR spin-label TOAC into peptide sequences by Fmoc SPPS. Incorporation of this derivative and the following residue is best achieved using HATU activation. TFA/water/TIS should be used for cleavage of TOAC-containing peptides. The use of EDT should be avoided as it can cause permanent reduction of the nitroxide radical. Following cleavage, the TOAC peptide should be treated with aqueous ammonia in air to regenerate the nitroxide from the hydroxylamine that is generated by the TFA treatment. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-TOAC-OH, 2,2,6,6-Tetramethylpiperidine-N-oxyl-4-(9-fluorenylmethyloxycarbonyl-amino)-4-carboxylic acid. Product Category: Amino Acids. CAS No. 93372-25-9. Mole weight: 437.51. Product ID: ACM93372259-1. Alfa Chemistry ISO 9001:2015 Certified.
This pseudoproline dipeptide is undoubtedly the most effective and simplest to use tool for overcoming aggregation and enhancing peptide quality in Fmoc SPPS for peptide containing the Trp-Ser dipeptide motif. It consists of a dipeptide in which the serine residue has been reversibly protected as a structure-breaking proline-like TFA-labile oxazolidine. The reason the pseudoproline residue is introduced as a dipeptide is because it avoids the need to acylate the hindered oxazolidine nitrogen. This has the added advantage of extending the peptide chain by two residues in one step. The serine residue is regenerated during the normal TFA-mediated cleavage reaction. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Trp(Boc)-Ser(psiMe,Mepro)-OH. Product Category: Amino Acids. CAS No. 908601-15-0. Mole weight: 653.72. Product ID: ACM908601150. Alfa Chemistry ISO 9001:2015 Certified. Categories: Fmoc-Trp(Boc)-Ser(Psi(Me,Me)pro)-OH.
This pseudoproline dipeptide is undoubtedly the most effective and simplest to use tool for overcoming aggregation and enhancing peptide quality in Fmoc SPPS for peptide containing the Trp-Thr dipeptide motif. It consists of a dipeptide in which the threonine residue has been reversibly protected as a structure-breaking proline-like TFA-labile oxazolidine. The reason the pseudoproline residue is introduced as a dipeptide is because it avoids the need to acylate the hindered oxazolidine nitrogen. This has the added advantage of extending the peptide chain by two residues in one step. The threonine residue is regenerated during the normal TFA-mediated cleavage reaction. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Trp(Boc)-Thr(psiMe,Mepro)-OH. Product Category: Amino Acids. CAS No. 936707-21-0. Mole weight: 667.75. Product ID: ACM936707210. Alfa Chemistry ISO 9001:2015 Certified.
Building block for introduction of typtophan by Fmoc SPPS. Superceded by Fmoc-Trp(Boc)-OH. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Trp-OH, N-α-Fmoc-L-tryptophan. Product Category: Amino Acids. CAS No. 35737-15-6. Mole weight: 426.46. Product ID: ACM35737156. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Trp-OH-15N2
Fmoc-Trp-OH-15N2. Uses: Peptide synthesis. Additional or Alternative Names: L-Tryptophan-15N2, α-N-Fmoc derivative. Product Category: Amino Acids. CAS No. 1217472-80-4. Mole weight: 428.45. Canonical SMILES: OC(=O)[C@H](Cc1c[15nH]c2ccccc12)[15NH]C(=O)OCC3c4ccccc4-c5ccccc35. Product ID: ACM1217472804. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-trp-opfp
Fmoc-trp-opfp. Uses: Designed for use in research and industrial production. Additional or Alternative Names: FMOC-L-TRYPTOPHAN PENTAFLUOROPHENYL ESTER;FMOC-TRYPTOPHAN-OPFP;FMOC-TRP-OPFP;N-ALPHA-FMOC-L-TRYPTOPHAN PENTAFLUOROPHENYL ESTER;NALPHA-9-Fluorenylmethoxycarbonyl-L-tryptophanpentafluoroph;NALPHA-9-Fluorenylmethoxycarbonyl-L-tryptophan pentafluorophenyl es. Product Category: Heterocyclic Organic Compound. CAS No. 86069-87-6. Molecular formula: C32H21F5N2O4. Mole weight: 592.52. Purity: 0.96. IUPACName: (2,3,4,5,6-pentafluorophenyl) (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1H-indol-3-yl)propanoate. Canonical SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NC(CC4=CNC5=CC=CC=C54)C(=O)OC6=C(C(=C(C(=C6F)F)F)F)F. Density: 1.452g/cm³. Product ID: ACM86069876. Alfa Chemistry ISO 9001:2015 Certified.
The side-chain ClTrt group can be removed with 1% TFA/ 5% TIS in DCM, enabling the side-chain hydroxyl group to be selectively modified whilst the derivative is attached to the solid support during Fmoc SPPS. Uses: Fmoc solid-phase peptide synthesis. Additional or Alternative Names: Fmoc-Tyr(2-ClTrt)-OH, N-α-Fmoc-O-2-chlorotrityl-L-tyrosine. Product Category: Amino Acids. CAS No. 350241-80-4. Molecular formula: C43H34ClNO5. Mole weight: 680.2. Product ID: ACM350241804-2. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Tyr(2-ClTrt)-OH
The side-chain ClTrt group can be removed with 1% TFA/ 5% TIS in DCM, enabling the side-chain hydroxyl group to be selectively modified whilst the derivative is attached to the solid support during Fmoc SPPS. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Tyr(2-ClTrt)-OH, N-α-Fmoc-O-2-chlorotrityl-L-tyrosine. Product Category: Amino Acids. CAS No. 350241-80-4. Mole weight: 680.19. Product ID: ACM350241804-1. Alfa Chemistry ISO 9001:2015 Certified.
Standard building block for introduction of O-methyl-tyrosine amino-acid residues by Fmoc SPPS. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Tyr(Me)-OH, N-α-Fmoc-O-methyl-L-tyrosine. Product Category: Amino Acids. CAS No. 77128-72-4. Molecular formula: C25H23NO5. Mole weight: 417.45. Product ID: ACM77128724. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Tyr(Me)-OH
Fmoc-Tyr(Me)-OH is a tyrosine derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 77128-72-4. Pack Sizes: 10 g; 25 g; 100 g. Product ID: HY-W010943.
Fmoc-Tyr-OH
Fmoc-Tyr-OH is a tyrosine derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 92954-90-0. Pack Sizes: 25 g; 100 g. Product ID: HY-W009003.
Fmoc-Tyr-OH
Fmoc-Tyr-OH. Group: Biochemicals. Alternative Names: N-Fmoc-L-tyrosine. Grades: Highly Purified. CAS No. 92954-90-0. Pack Sizes: 5g, 10g, 25g, 50g, 100g. Molecular Formula: C24H21NO5. US Biological Life Sciences.
Worldwide
Fmoc-Tyr-OH
A useful derivative for the synthesis of phosphotyrosine peptides by the global Fmoc SPPS phosphorylation methodology. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Tyr-OH, N-α-Fmoc-L-tyrosine. Product Category: Amino Acids. CAS No. 92954-90-0. Molecular formula: C24H21NO5. Mole weight: 403.43. Product ID: ACM92954900. Alfa Chemistry ISO 9001:2015 Certified. Categories: (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(4-hydroxyphenyl)propanoic acid.
Fmoc-Tyr-OH-15N
Fmoc-Tyr-OH-15N. Uses: Peptide synthesis. Additional or Alternative Names: N-(9-Fluorenylmethoxycarbonyl)-L-tyrosine-15N, L-Tyrosine-15N, N-Fmoc derivative. Product Category: Amino Acids. CAS No. 125700-34-7. Mole weight: 404.42. Canonical SMILES: OC(=O)[C@H](Cc1ccc(O)cc1)[15NH]C(=O)OCC2c3ccccc3-c4ccccc24. Product ID: ACM125700347-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-tyr-ome
Fmoc-tyr-ome. Uses: Designed for use in research and industrial production. Additional or Alternative Names: FMOC-TYR-OME;METHYL D-AMINOLEVULINATE HYDROCHLORIDE. Product Category: Heterocyclic Organic Compound. CAS No. 82911-79-3. Molecular formula: C25H23NO5. Product ID: ACM82911793. Alfa Chemistry ISO 9001:2015 Certified. Categories: (S)-Methyl 2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-hydroxyphenyl)propanoate.
A useful derivative for the synthesis of phosphotyrosine peptides by Fmoc SPPS. Pyrophosphate formation has been noted in peptides containing adjacent Tyr(PO3H2) residues. An evaluation of the optimal coupling conditions for introduction of this residue has been made. Uses: Peptide synthesis. Additional or Alternative Names: Nα-Fmoc-O-phospho-L-tyrosine, N-α-Fmoc-O-phospho-L-tyrosine. Product Category: Amino Acids. CAS No. 147762-53-6. Mole weight: 483.41. Canonical SMILES: OC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)OCC2c3ccccc3-c4ccccc24. Product ID: ACM147762536-1. Alfa Chemistry ISO 9001:2015 Certified. Categories: (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-[4-(phosphonooxy)phenyl]propanoic acid.
An excellent building block for the preparation of phosphotyrosine-containing peptides by Fmoc SPPS. This derivative can be introduced using standard activation methods, such as PyBOPand TBTU. Using this reagent, even peptides containing multiple phosphorylation sites have been prepared efficiently by standard Fmoc SPPS methods. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Tyr(PO(OBzl)OH)-OH, N-α-Fmoc-O-benzyl-L-phosphotyrosine. Product Category: Amino Acids. CAS No. 191348-16-0. Molecular formula: C31H28NO8P. Mole weight: 573.53. Product ID: ACM191348160-1. Alfa Chemistry ISO 9001:2015 Certified.
A novel derivative for the synthesis of sulfotyrosine-containing peptides by Fmoc SPPS. The sulfate neopentyl group is stable to TFA, and thus protects the sulfotyrosine residue from degradation during the cleavage reaction, but is easily cleaved post-cleavage by treatment of the peptide with aqueous ammonium acetate. Group: Biochemicals. Grades: Highly Purified. CAS No. 878408-63-0. Pack Sizes: 1g. Molecular Formula: C??H??NO?S, Enantiomeric. US Biological Life Sciences.
Worldwide
Fmoc-Tyr(SO3nP)-OH
A novel derivative for the synthesis of sulfotyrosine-containing peptides by Fmoc SPPS. The sulfate neopentyl group is stable to TFA, and thus protects the sulfotyrosine residue from degradation during the cleavage reaction, but is easily cleaved post-cleavage by treatment of the peptide with aqueous ammonium acetate. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Tyr(SO3nP)-OH, N-Fmoc-O-(2,2 dimethylpropylsulfo)-L-tyrosine. Product Category: Amino Acids. CAS No. 878408-63-0. Molecular formula: C29H31NO8S. Mole weight: 553.62. IUPACName: (2S)-3-[4-(2,2-dimethylpropoxysulfonyloxy)phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid. Canonical SMILES: CC(C)(C)COS(=O)(=O)OC1=CC=C(C=C1)CC(C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24. Product ID: ACM878408630. Alfa Chemistry ISO 9001:2015 Certified. Categories: Fmoc-Tyr(SO2(ONeopentyl))-OH.
Fmoc-Tyr(tBu)-OH
Fmoc-Tyr(tBu)-OH is a tyrosine derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 71989-38-3. Pack Sizes: 25 g; 100 g; 500 g. Product ID: HY-W008016.
Fmoc-Tyr(tBu)-OH
High purity Fmoc-protected amino acid for research and process production of peptides, with very low levels of dipeptide, free-amino acids and acetic acid impurities. Standard building block for introduction of tyrosine amino-acid residues by Fmoc SPPS. Uses: Fmoc-tyr(tbu)-oh novabiochem®. cas 71989-38-3, molar mass 459.55 g/mol. Additional or Alternative Names: Fmoc-Tyr(tBu)-OH, N-α-Fmoc-O-t.-butyl-L-tyrosine. Product Category: Amino Acids. CAS No. 71989-38-3. Molecular formula: C28H29NO5. Mole weight: 459.53. Purity: Peak Area by HPLC ≥95%. Product ID: ACM71989383. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Tyr(tBu)-OH
Fmoc-Tyr(tBu)-OH. Group: Biochemicals. Grades: Highly Purified. CAS No. 71989-38-3. Pack Sizes: 50g, 100g, 250g, 500g, 1kg. Molecular Formula: C28H29NO5. US Biological Life Sciences.
This pseudoproline dipeptide is undoubtedly the most effective and simplest to use tool for overcoming aggregation and enhancing peptide quality in Fmoc SPPS for peptide containing the Tyr-Ser dipeptide motif. It consists of a dipeptide in which the serine residue has been reversibly protected as a structure-breaking proline-like TFA-labile oxazolidine. The reason the pseudoproline residue is introduced as a dipeptide is because it avoids the need to acylate the hindered oxazolidine nitrogen. This has the added advantage of extending the peptide chain by two residues in one step. The serine residue is regenerated during the normal TFA-mediated cleavage reaction. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Tyr(tBu)-Ser(psiMe,Mepro)-OH. Product Category: Amino Acids. CAS No. 878797-09-2. Mole weight: 586.67. Product ID: ACM878797092. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Tyr(tBu)-Ser[Psi(Me,Me)Pro]-OH 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. CAS No. 878797-09-2. Pack Sizes: 1g, 5g, 10g. US Biological Life Sciences.
Worldwide
Fmoc-Tyr(tBu)-Thr(psiMe,Mepro)-OH
This pseudoproline dipeptide is undoubtedly the most effective and simplest to use tool for overcoming aggregation and enhancing peptide quality in Fmoc SPPS for peptide containing the Tyr-Thr dipeptide motif. It consists of a dipeptide in which the threonine residue has been reversibly protected as a structure-breaking proline-like TFA-labile oxazolidine. The reason the pseudoproline residue is introduced as a dipeptide is because it avoids the need to acylate the hindered oxazolidine nitrogen. This has the added advantage of extending the peptide chain by two residues in one step. The threonine residue is regenerated during the normal TFA-mediated cleavage reaction. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Tyr(tBu)-Thr(psiMe,Mepro)-OH. Product Category: Amino Acids. CAS No. 920519-31-9. Mole weight: 600.7. Product ID: ACM920519319-1. Alfa Chemistry ISO 9001:2015 Certified.