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The N-Fmoc protected Sphingosine, a selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets; does not inhibit protein kinase A or myosin light chain kinase; inhibits calmodulin-dependent enzymes. Group: Biochemicals. Alternative Names: (2S, 3R, 4E) -2-Fluorenyl methoxycarbonyl amino-4-octadecen-1, 3-diol. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences.
A useful tool for the synthesis of branched, side-chain modified, cyclic peptides and peptide tools for click chemistry by Fmoc SPPS. The side-chain azido group is completely stable to piperidine and TFA, but can be readily converted to an amine on the solid phase or in solution by reduction with thiols or phosphines. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-γ-azidohomoalanine. Product Category: Amino Acids. CAS No. 942518-20-9. Molecular formula: C19H18N4O4. Mole weight: 366.37. Purity: Peak Area by HPLC ≥95%. Product ID: ACM942518209. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-γ-benzyl ester-L-glutamyl chloride
Fmoc-γ-benzyl ester-L-glutamyl chloride. Group: Biochemicals. Alternative Names: Fmoc-L-Glu(OBzl)-Cl. Grades: Highly Purified. CAS No. 123622-36-6. Pack Sizes: 1g, 2g, 5g. US Biological Life Sciences.
Fmoc-GGFG-DXd is a drug-linker conjugate for ADC. Fmoc-GGFG-DXd contains a ADC linker Fmoc-GGFG and a DNA topoisomerase I inhibitor DXd (HY-13631D)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1599440-11-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156848.
Fmoc-GGFG-OH
Fmoc-GGFG-OH is a protease cleavable linker used for the antibody-drug conjugate (ADC). Synonyms: Fmoc-Gly-Gly-Phe-Gly-OH; (((9H-Fluoren-9-yl)methoxy)carbonyl)glycylglycyl-L-phenylalanylglycine. CAS No. 1817857-75-2. Molecular formula: C30H30N4O7. Mole weight: 558.60.
Fmoc-Gla(OtBu)2-OH
Fmoc-Gla(OtBu)2-OH is a building block for the introduction of γ-carboxyglutamic acid (Gla). γ-Carboxylation of glutamic acid is a rare post-translational modification that occurs in blood coagulation factors and in some snake and cone snail venoms. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Gla(OtBu)2-OH, Fmoc-γ-carboxy-Glu(OtBu) 2-OH, Fmoc-gamma-carboxy-L-glutamic acid gamma,gamma-di-t-butyl ester. Product Category: Amino Acids. CAS No. 111662-64-7. Molecular formula: C29H35NO8. Mole weight: 525.59. Purity: Peak Area by HPLC ≥95%. Product ID: ACM111662647-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Gln(Dmcp)-OH
A superior derivative to Fmoc-Gln(Trt)-OH for the synthesis of Gln-containing peptides by Fmoc SPPS. Fmoc-Gln(Dmcp)-OH is more soluble in DMF than Fmoc-Gln(Trt)-OH, thereby facilitating coupling reactions at higher concentration. Cleavage of the Dmcp group is rapid, even when the residue is located at the N-terminus of a peptide. Coupling of Dmcp-protected derivatives is faster than that of the corresponding hindered Trt derivatives. Dmcp-protected peptides have enhanced solubility. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Gln(Dmcp)-OH, N-α-Fmoc-N-γ-(1-cyclopropyl-1-methylethyl)-L-glutamine. Product Category: Amino Acids. CAS No. 172947-20-5. Mole weight: 450.53. Product ID: ACM172947205. Alfa Chemistry ISO 9001:2015 Certified.
Building block for introduction of glutamine by Fmoc SPPS. Not compatible with uronium and phosphonium coupling reagents. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Gln-OH, N-α-Fmoc-L-glutamine. Product Category: Amino Acids. CAS No. 71989-20-3. Mole weight: 368.38. Product ID: ACM71989203. Alfa Chemistry ISO 9001:2015 Certified. Categories: N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamine.
Fmoc-Gln-OH-[13C5,15N2]
Fmoc-Gln-OH-[13C5,15N2] is a labelled L-Glutamine-N-FMOC. Glutamine is an α-amino acid used in the biosynthesis of proteins. Synonyms: L-Glutamine-13C5,15N2-N-FMOC; Nalpha-Fmoc-L-glutamine 13C5,15N2. Grade: 98% by CP; 99% atom 13C; 99% atom 15N. Molecular formula: C15[13C]5H20[15N]2O5. Mole weight: 375.33.
2-Chlorotrityl-Chloride-Resin is less acid-labile than Trityl Resin, and is widely used for solid phase immobilization. It has been used with the Fmoc/tBu methodology in the microwave-assisted solid phase peptide synthesis.
Fmoc-Gln(Trt)-Alko-PEG Resin
Wang resins are the standard supports for the preparation of peptide acids by the Fmoc batch solid phase synthesis strategy. Fmoc amino acids are pre-loaded to Wang resins so that that epimerization and dipeptide formation are minimized. Synonyms: Fmoc-Gln(Trt)-Wang-PEG Resin; N-α-(9-Fluorenylmethoxycarbonyl)-N-δ-trityl-L-glutamine p-methoxybenzyl alcohol polyethyleneglycol resin.
Fmoc-Gln(Trt)-OH. Group: Biochemicals. Alternative Names: N-a-Fmoc-N-γ-trityl-L-glutamine. Grades: Highly Purified. CAS No. 132327-80-1. Pack Sizes: 50g, 100g, 250g, 500g, 1kg. Molecular Formula: C39H34N2O5. US Biological Life Sciences.
Worldwide
Fmoc-Gln(Trt)-OH
Fmoc-Gln(Trt)-OH is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 132327-80-1. Pack Sizes: 10 mM * 1 mL; 10 g; 25 g. Product ID: HY-W013081.
Fmoc-Gln(Trt)-OH
High purity Fmoc-protected amino acid for research and process production of peptides, with very low levels of dipeptide, free-amino acids and acetic acid impurities. Fmoc-Gln(Trt)-OH has good solubility properties in most organic solvents, and its use has been shown to result in significantly purer peptides than other derivatives used for the introduction of Gln. Coupling can be performed by standard procedures. The trityl-protecting group is normally removed by 95% TFA in 1-3 hours, with no alkylation of Trp. Literature references P. Sieber, et al. (1991) Tetrahedron Lett., 32, 739. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Gln(Trt)-OH, N-α-Fmoc-N-γ-trityl-L-glutamine. Product Category: Amino Acids. CAS No. 132327-80-1. Molecular formula: C39H34N2O5. Mole weight: 610.7. Product ID: ACM132327801. Alfa Chemistry ISO 9001:2015 Certified. Categories: (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-[(triphenylmethyl)carbamoyl]butanoic acid.
Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-136154.
Fmoc-Glu(Cys(Fmoc)-Gly-OH)-OH
N,S-Bis-Fmoc-glutathione is a very potent inhibitor of mammalian glyoxalase II (Ki = 0.08 μM for glyoxalase II purified from calf liver). Synonyms: N,S-Bis-Fmoc-glutathione. CAS No. 149438-56-2. Molecular formula: C40H37N3O10S. Mole weight: 751.80.
Fmoc-Glu-O-2-PhiPr
An excellent tool for the synthesis of head-to-tail cyclic peptides by Fmoc SPPS. The 2-PhiPr group can be selectively removed on the resin with 1% TFA in DCM in the presence of the standard t-butyl-based side-chain protecting groups. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Glu-O-2-PhiPr, N-α-Fmoc-L-glutamic acid α-2-phenylisopropyl ester. Product Category: Amino Acids. CAS No. 207305-97-3. Mole weight: 487.54. Product ID: ACM207305973-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Glu(O-2-PhiPr)-OH
Quasi-orthogonally-protected Glu derivative. The 2-PhiPr group can be removed selectively in the presence of tBu-based protecting groups by treatment with 1% TFA in DCM , making this derivative an extremely useful tool for the preparation of cyclic peptides by Fmoc SPPS. or for library synthesis. For the on-resin synthesis of side-chain to side-chain lactam bridged peptides, the combination of Lys(Mtt) and Glu(O-2-PhiPr) is particularly advantageous since both side-chains can be simultaneously unmasked in a single step. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Glu(O-2-PhiPr)-OH, N-α-Fmoc-L-glutamic acid γ-2-phenylisopropyl ester. Product Category: Amino Acids. CAS No. 200616-39-3. Mole weight: 487.54. Product ID: ACM200616393-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Glu(OAII)-OH
Fmoc-Glu(OAII)-OH. Group: Biochemicals. Grades: Highly Purified. CAS No. 133464-46-7. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C23H23NO6. US Biological Life Sciences.
Worldwide
Fmoc-Glu-OAll
Orthogonally-protected building block for the synthesis of head-to-tail cyclic peptides by Fmoc SPPS.The α-allyl ester can be selectively removed in the presence of Fmoc- and tBu-based protecting groups by treatment with Pd(Ph3P)4/ CHCl3/AcOH/NMM, thereby facilitating the synthesis of branched esters and amides, and lactones and lactams incorporating a glutamyl unit. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Glu-OAll, N-α-Fmoc-L-glutamic acid α-allyl ester. Product Category: Amino Acids. CAS No. 144120-54-7. Molecular formula: C23H23NO6. Mole weight: 409.43. Product ID: ACM144120547. Alfa Chemistry ISO 9001:2015 Certified. Categories: N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-glutamic-acid-alpha allyl ester.
Fmoc-Glu-OAll
Fmoc-Glu-OAll is a glutamic acid derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 144120-54-7. Pack Sizes: 5 g; 10 g; 25 g; 100 g. Product ID: HY-W008475.
Fmoc-Glu(OAll)-OH
Fmoc-Glu(OAll)-OH is a glutamic acid derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 133464-46-7. Pack Sizes: 5 g; 10 g. Product ID: HY-W010965.
Fmoc-Glu(OAll)-OH
Orthogonally-protected building block for the synthesis of peptides modified at the Glu side chain by Fmoc SPPS. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Glu(OAll)-OH. Product Category: Amino Acids. CAS No. 133464-46-7. Molecular formula: C23H23NO6. Mole weight: 409.43. Product ID: ACM133464467. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Glu(OAll)-Wang Resin
Fmoc-Glu(OAll)-Wang Resin. Group: Fmoc-amino acid-wang resins. Alternative Names: N-Fmoc-L-glutamic acid gamma-allyl ester Wang resin. Pack Sizes: 1g, 5g.
Fmoc-Glu-OBzl
Building block for introduction of aspartic acid bearing TFA-labile benzyl ester protection. Benzyl group is removed by hydrogenation over Pd/C or with strong acids such as TFMSA. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Glu-OBzl, N-α-Fmoc-L-glutamic acid α-benzyl ester. Product Category: Amino Acids. CAS No. 122350-52-1. Mole weight: 459.49. Product ID: ACM122350521-1. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-Glu(OBzl)-OH
Building block for introduction of glutamic acid bearing TFA-labile benzyl ester side-chain protection. Benzyl group is removed by hydrogenation over Pd/C or with strong acids such as TFMSA. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Glu(OBzl)-OH, N-α-Fmoc-L-glutamic acid γ-benzyl ester. Product Category: Amino Acids. CAS No. 123639-61-2. Mole weight: 459.49. Product ID: ACM123639612. Alfa Chemistry ISO 9001:2015 Certified. Categories: DTXSID10553436.
Fmoc-Glu-ODmab
Quasi-orthogonally-protected Glu derivative. The Dmab group can be removed selectively in the presence of tBu-based protecting groups by treatment with 2% hydrazine in DMF , making this derivative an extremely useful tool for the preparation of cyclic peptides by Fmoc SPPS. or for library synthesis. For the on-resin synthesis of side-chain to side-chain lactam bridged peptides, the combination of Lys(ivDde) and Glu(ODmab) is particularly advantageous since both side-chains can be simultaneously unmasked in a single step. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-Glu-ODmab, N-α-Fmoc-L-glutamic acid α-4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]-amino} benzyl ester. Product Category: Amino Acids. CAS No. 172611-75-5. Mole weight: 680.79. Product ID: ACM172611755. Alfa Chemistry ISO 9001:2015 Certified.