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| Product | Description | |
|---|---|---|
| GYY-4137 Morpholine salt | GYY-4137 Morpholine salt is a novel water-soluble and slow releasing Hydrogen sulfide(H2S) donor. It protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis in rats. It inhibits the inflammatory response by suppressing the activation of nuclear factor-kappa B and mitogen-activated protein kinases in Coxsackie virus B3-infected rat cardiomyocytes. It exhibits potent anti-cancer activity. It exhibits vasodilator and antihypertensive activity in rats, in either the acute or chronic hypertension models. It does not influence vascular smooth muscle cell viability in culture. It also protects against endotoxic shock in rats, inhibiting tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 production and reducing NF-κB activation, iNOS and cyclooxygenase-2 expression, and NO and prostaglandin E2 generation. Uses: Gyy-4137 morpholine salt inhibits the inflammatory response. it exhibits potent anti-cancer activity. it exhibits vasodilator and antihypertensive activity. Synonyms: GYY4137; GYY-4137; GYY 4137; GYY 4137 morpholine salt; ZYJ1122; ZYJ 1122; ZYJ-1122. GYY4137 Morpholine salt;(4-Methoxyphenyl)morpholino-phosphinodithioic acid compound with morpholine;ZYJ1122 morpholine salt;ZYJ-1122 morpholine salt. Grades: ≥95%. CAS No. 106740-09-4. Molecular formula: C15H25N2O3PS2. Mole weight: 376.47. |  |
| GZ-793A | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| GZD824 | GZD824 potently suppressed proliferation of Bcr-Abl-positive K562 and Ku812 human CML cells with IC(50) values of 0.2 and 0.13 nM, respectively. It also displayed good oral bioavailability (48.7%), a reasonable half-life (10.6 h), and promising in vivo antitumor efficacy. GZD824 induced tumor regression in mouse xenograft tumor models driven by Bcr-Abl(WT) or the mutants and significantly improved the survival of mice bearing an allograft leukemia model with Ba/F3 cells harboring Bcr-Abl(T315I). Synonyms: GZD824; GZD 824; GZD-824. Grades: >98%. CAS No. 1257628-77-5. Molecular formula: C29H27F3N6O. Mole weight: 532.56. | |
| GZD824 Dimesylate | GZD824 Dimesylate is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively. Synonyms: Olverembatinib dimesylate; HQP1351 dimesylate; GZD 824 Dimesylate; GZD-824 Dimesylate; 3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide dimethanesulfonate; Benzamide, 4-methyl-N-(4-((4-methyl-1-piperazinyl)methyl)-3-(trifluoromethyl)phenyl)-3-(2-(1H-pyrazolo(3,4-b)pyridin-5-yl)ethynyl)-, methanesulfonate (1:2). Grades: ≥99%. CAS No. 1421783-64-3. Molecular formula: C29H27F3N6O.2CH4O3S. Mole weight: 724.77. | |
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