A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
HJC 0350. Group: Biochemicals. Grades: Purified. CAS No. 885434-70-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
HJC0416 hydrochloride
HJC0416 hydrochloride is a potent anticancer agent, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). Synonyms: HJC0416 (hydrochloride). CAS No. 2415263-08-8. Molecular formula: C18H18Cl2N2O4S. Mole weight: 429.32.
HJM-561
HJM-561 is a selective and effective orally active EGFR PROTAC degrader. HJM-561 is able to overcome the triple EGFR mutations that are resistant to Osimertinib (HY-15772). HJM-561 exhibits potent degradation of EGFR Del19/T790M/C797S (DC50: 9.2 nM) and L858R/T790M/C797S (DC50: 5.8 nM), and has anti-tumor activity (pink: EGFR ligand (HY-12857); blue: CRBN ligand (HY-A0003); black: linker)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2570251-68-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156698.
HKB99
HKB99 is an allosteric inhibitor of phosphoglycerate mutase 1 (PGAM1). HKB99 induces apoptosis. HKB99 inhibits the formation of invasive pseudopodia and inhibits migration. HKB99 increases the oxidative stress, activates JNK/c-Jun and suppresses AKT and ERK. HKB99 can be used for the research of non-small-cell lung cancer (NSCLC)[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2414908-90-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148510.
H+/K+-exchanging ATPase
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. A gastric mucosal enzyme that catalyses the efflux of one H+ and the influx of one K+ per ATP hydrolysed. Group: Enzymes. Synonyms: H+-K+-ATPase; H,K-ATPase; (K+ + H+)-ATPase. Enzyme Commission Number: EC 3.6.3.10. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4647; H+/K+-exchanging ATPase; EC 3.6.3.10; H+-K+-ATPase; H,K-ATPase; (K+ + H+)-ATPase. Cat No: EXWM-4647.
HKI 357. Group: Biochemicals. Grades: Purified. CAS No. 848133-17-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
HKI 357
HKI 357 is a potent and irreversible dual inhibitor of ErbB2 (HER2) and EGFR (IC50 = 33 and 34 nM, respectively). It inhibits EGFR autophosphorylation and proliferation of NCI-H1975 cells containing L858R and T790M mutations. Uses: Antitumor agent. Synonyms: HKI 357; HKI357; HKI-357; (2E)-N-[[4-[[(3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide. Grade: ≥98% by HPLC. CAS No. 848133-17-5. Molecular formula: C31H29ClFN5O3. Mole weight: 574.05.
HKI-357
HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation. Uses: Designed for use in research and industrial production. Additional or Alternative Names: HKI-357; HKI357; HKI 357. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 848133-17-5. Molecular formula: C31H29ClFN5O3. Mole weight: 574.05. Purity: >98%. IUPACName: (E)-N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide. Canonical SMILES: O=C(NC1=C(OCC)C=C2N=CC(C#N)=C(NC3=CC=C(OCC4=CC=CC(F)=C4)C(Cl)=C3)C2=C1)/C=C/CN(C)C. Product ID: ACM848133175. Alfa Chemistry ISO 9001:2015 Certified.
HKOCl-3
HKOCl-3 is a highly sensitive and selective fluorescent probe for detecting hypochlorous acid.Ex: 490 nm; Em 527 nm[1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 2031170-80-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130025.
HKOH-1r
HKOH-1r is a highly sensitive green fluorescent probe for the specific detection of ·OH in living cells with a maximum excitation wavelength and emission wavelength of 500 nm and 520 nm, respectively [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 2138472-08-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-D1159.
HKPerox-2
HKPerox-2 is a highly sensitive green fluorescent probe for the specific detection of H 2 O 2 in living cells with a maximum excitation wavelength and emission wavelength of 520 nm and 543 nm, respectively [2]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 2245230-79-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-D1157.
HKPLP
HKPLP is an antibacterial peptide isolated from Hippocampus kuda. Synonyms: Phe-Leu-Gly-Leu-Ile-Phe-His-Gly-Leu-Val-His-Ala-Gly-Lys-Leu-Ile-His-Gly-Leu-Ile-His-Arg-Asn-Arg-Gly. Grade: 96.1%.
HL 010183
HL 010183 is a metformin derivative exhibiting potent antitumor effect. It inhibits proliferation and invasion of Hs578T triple-negative (TN) breast cancer cells. Uses: Antitumor agent. Synonyms: HL 010183; HL010183; HL-010183. Grade: 99%. CAS No. 1429218-03-0. Molecular formula: C14H20N6.HCl. Mole weight: 308.81.
HL1
HL1 is a ligand for tridentate Schiff bases and is a potential fluorescent probe for metal ions. HL1 exhibits photoluminescence at a weak and strong excitation wavelength of 415 nm [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 202828-10-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164055.
HL-60 Electroporation Kit
Electroporation buffer optimized for HL60 Plasmacytoma Cells. Optimized electroporation protocol provided for transfection of si/miRNA, DNA, mRNA, and small proteins. Feature high transfection efficacy and cell viability. Uses: Electroporation of DNA, RNA, protein and small molecules. Product ID: 1752.
HLA class II histocompatibility antigen, DO beta chain (232-240)
HLA class II histocompatibility antigen, DO beta chain (232-240) is a bioactive peptide of HLA class II histocompatibility antigen, DO beta chain. HLA class II histocompatibility antigen, DO beta chain binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. Synonyms: HLA class II histocompatibility antigen, DX beta chain (232-240); MHC class II antigen DQB2 (232-240).
H-L-Beta-homothr-oh hcl
H-L-Beta-homothr-oh hcl. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (3R,4R)-3-Amino-4-hydroxypentanoic acid hydrochloride, 336182-14-0, L-beta-Homo-Thr-OH HCl, 03767_FLUKA, L-beta-Homothreonine hydrochloride, MolPort-003-925-341, AKOS006282796, AK-23909, BR-23909, KB-207532, W5530, (3R,4R)-3-AMINO-4-HYDROXYPENTANOIC ACID HCL. Product Category: Heterocyclic Organic Compound. CAS No. 336182-14-0. Molecular formula: C5H11NO3.HCl. Mole weight: 169.6. Purity: 0.95. IUPACName: (3R,4R)-3-amino-4-hydroxypentanoic acid;hydrochloride. Canonical SMILES: CC(C(CC(=O)O)N)O.Cl. Product ID: ACM336182140. Alfa Chemistry ISO 9001:2015 Certified.
HLCL61
HLCL61 is a potent and selective protein arginine methyltransferase 5 (PRMT5) inhibitor. It is used for treatment of acute myeloid leukemia. It resulted in significantly increased expression of miR-29b and consequent suppression of Sp1 and FLT3 in acute myeloid leukemia cells. Uses: Hlcl61 is used for treatment of acute myeloid leukemia. Synonyms: HLCL-61; HLCL 61; 9-Ethyl-N-[(2-methoxyphenyl)methyl]-9H-carbazole-3-methanamine. Grade: 98%. CAS No. 586395-74-6. Molecular formula: C23H24N2O. Mole weight: 344.19.
HLCL-61 hydrochloride
The hydrochloride salt form of HLCL-61, an effective inhibitor of PRMT5, could probably useful in the treatment of acute myeloid leukemia. Uses: The hydrochloride salt form of hlcl-61 is an effective inhibitor of prmt5 and could probably useful in the treatment of acute myeloid leukemia. Synonyms: 1-(9-ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride; HLCL61; HLCL 61; HLCL-61. Grade: 98%. CAS No. 1158279-20-9. Molecular formula: C23H25ClN2O. Mole weight: 380.91.
HLCL65 hydrochloride
HLCL65 hydrochloride is a first-in-class inhibitor of PRMT5. HLCL65 selectively inhibits Th1 cell proliferation (IC50 value 1.1 μM). In vivo, HLCL65 suppresses recall T cell responses and reduces inflammation in delayed-type hypersensitivity and clinical disease in experimental autoimmune encephalomyelitis mouse models; In vitro, HLCL65 effectively inhibits symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples. Synonyms: HLCL65 hydrochloride; HLCL 65 hydrochloride; HLCL-65 hydrochloride; 1-(6-bromo-9-ethylcarbazol-3-yl)-N-[(2-methoxyphenyl)methyl]methanamine hydrochloride. Grade: 99%. Molecular formula: C23H23BrN2O.HCl. Mole weight: 459.81.
H-Leu-2-Chlorotrityl Resin
2-Chlorotrityl-Chloride-Resin is less acid-labile than Trityl Resin, and is widely used for solid phase immobilization. It has been used with the Fmoc/tBu methodology in the microwave-assisted solid phase peptide synthesis.
H-Leu-2-Cl-Trt Resin
Alfa Chemistry's amino acid 2-Cl-Trt resins are available in loadings ranging from 0.4 to 0.7 mmol/g. Since the linked amino acids are N-protected, these resins can be used without pretreatment. Group: Amino acid 2-cl-trt resins. Alternative Names: L-Leucine-2-chlorotrityl resin. Pack Sizes: 5g, 25g.
H-Leu-Gly-Leu-Leu-Leu-Arg-His-Leu-Arg-His-His-Ser-Asn-Leu-Leu-Ala-Asn-Ile-OH, the peptide sequence B18 derived from membrane-associated sea urchin sperm protein-binding proteins, triggers fusion between lipid vesicles. It has many similarities with viral fusion peptides. Grade: ≥95%. CAS No. 222557-92-8. Molecular formula: C94H160N32O22. Mole weight: 2090.48.
H-Leu-Gly-OH
H-Leu-Gly-OH is a Glycine (HY-Y0966) derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 686-50-0. Pack Sizes: 1 g; 5 g; 10 g; 25 g; 100 g. Product ID: HY-W016075.
H-Leu-his-leu-oh
H-Leu-his-leu-oh. Uses: Designed for use in research and industrial production. Additional or Alternative Names: H-LEU-HIS-LEU-OH. Product Category: Heterocyclic Organic Compound. CAS No. 126828-33-9. Molecular formula: C18H31N5O4. Mole weight: 381.47. Product ID: ACM126828339. Alfa Chemistry ISO 9001:2015 Certified.
H-Leu-nh2. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (R)-2-Amino-4-methylpentanamide; L-LEUCINE AMIDE; D-Leucine amide. Product Category: Heterocyclic Organic Compound. CAS No. 687-51-4. Molecular formula: C6H14N2O. Mole weight: 130.19. Purity: 0.96. IUPACName: (2S)-2-amino-4-methylpentanamide. Canonical SMILES: CC(C)CC(C(=O)N)N. ECNumber: 211-696-2. Product ID: ACM687514. Alfa Chemistry ISO 9001:2015 Certified.
H-Leu-OBzl.TOS
H-Leu-OBzl.TOS. CAS No: 1738-77-8
Sarchem Laboratories New Jersey NJ
H-Leu-ol-2-chlorotrityl resin
2-Chlorotrityl-Chloride-Resin is less acid-labile than Trityl Resin, and is widely used for solid phase immobilization. It has been used with the Fmoc/tBu methodology in the microwave-assisted solid phase peptide synthesis. Synonyms: H-Leu-ol-Trt(2-Cl)-Resin; H-Leu-ol-Barlos Resin; L-Leucinol 2-chlorotrityl resin.
H-Leu-OMe.HCl
H-Leu-OMe.HCl is a leucine derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 7517-19-3. Pack Sizes: 500 g. Product ID: HY-W016427.
H-Leu-Phe-OMe TFA
H-Leu-Phe-OMe TFA. Synonyms: (S)-Methyl 2-((S)-2-amino-4-methylpentanamido)-3-phenylpropanoate 2,2,2-trifluoroacetate; L-Phenylalanine, N-L-leucyl-, Methyl ester, Mono(trifluoroacetate); H Leu Phe OMe TFA. CAS No. 90072-18-7. Molecular formula: C18H25F3N2O5. Mole weight: 406.40.
H-LEU-PRO-OH HCL
H-LEU-PRO-OH is a substrate for skin fibroblast prolidase. Synonyms: L-Leucyl-L-proline hydrochloride; (S)-1-((S)-2-Amino-4-methylpentanoyl)pyrrolidine-2-carboxylic acid hydrochloride. Grade: >99%. CAS No. 87178-63-0. Molecular formula: C11H21ClN2O3. Mole weight: 264.75.
H-Leu-Pro-Pro-OH
H-Leu-Pro-Pro-OH, the proline-rich tripeptide, has ACE-inhibiting activity as IPP and VPP, with an IC50 of 9.6 μM. Synonyms: H-LPP-OH; L-leucyl-L-prolyl-L-proline; 1-(1-L-Leucyl-L-prolyl)-L-proline; leucyl-prolyl-proline. Grade: 95%. CAS No. 121305-26-8. Molecular formula: C16H27N3O4. Mole weight: 325.41.
H-Leu-Ser-p-nitro-Phe-Nle-Ala-Leu-OMe trifluoroacetate salt
H-Leu-Trp-OH, a natural product found in Trypanosoma brucei and Aeromonas veronii, is an ACE-inhibitory dipeptide with an IC50 of 6.6 μM. It is a substrate for aminopeptidase W (Km = 0.57 mM; kcat = 6770 min-1). Synonyms: H-LW-OH; L-leucyl-L-tryptophan; L-Leu-L-Trp-OH; (S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-3-(1H-indol-3-yl)-propionic acid. Grade: ≥95%. CAS No. 5156-22-9. Molecular formula: C17H23N3O3. Mole weight: 317.38.
hLF1-11
hLF1-11 is a synthetic peptide with potential antibacterial activity. Molecular formula: C56H95N25O14S1. Mole weight: 1374.6.
H-L-Hgn(Trt)-OH
H-L-Hgn(Trt)-OH.
HLI 373
HLI 373. Group: Biochemicals. Grades: Purified. CAS No. 502137-98-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
HLI 373
HLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3) that blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53 and activates p53-dependent transcription. HLI 373 has a therapeutic effect in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS. Synonyms: HLI373; HLI-373; HLI 373; NSC-373989; NSC 373989; NSC373989. 5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione dihydrochloride. Grade: ≥99% by HPLC. CAS No. 502137-98-6. Molecular formula: C18H23N5O2.2HCl. Mole weight: 414.33.
HLI373 dihydrochloride
HLI373 dihydrochloride is an efficacious Hdm2 inhibitor. HLI373 dihydrochloride inhibits the ubiquitin ligase activity of Hdm2. HLI373 dihydrochloride is effective in inducing apoptosis of several tumor cells that are sensitive to DNA-damaging agents [1]. Antimalarial activity [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1782531-99-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-108640A.
HLM006474
HLM006474 is an E2F transcription factor inhibitor that suppresses binding of DNA. It can promote cell differentiation of human pluripotent stem cells (hPSCs). Synonyms: HLM-006474; 7-[(4-ethoxy-3-methylphenyl)-(pyridin-2-ylamino)methyl]-2-methylquinolin-8-ol. Grade: >98%. CAS No. 353519-63-8. Molecular formula: C25H25N3O2. Mole weight: 399.48.
HLM006474
HLM006474 is a pan E2F inhibitor, which inhibits E2F4 DNA-binding with an IC50 of 29.8 ?M in A375 cells. Uses: Scientific research. Group: Signaling pathways. CAS No. 353519-63-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16667.
HLY78, a Lycorine (HY-N0288) derivative, is a potent activator of the Wnt/?-catenin signaling pathway. HLY78 targets the DIX domain of Axin and promotes the Axin-LRP6 (lipoprotein receptor-related protein 6) association, thus promoting LRP6 phosphorylation and Wnt signal transduction. HLY78 can be used for subarachnoid hemorrhage (SAH) research[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 854847-61-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122816.
HLY78
HLY78 is an activator of the Wnt/β-catenin pathway. It targets the DIX domain of Axin and potentiates the Axin-LRP6 association, thus promoting LRP6 phosphorylation and Wnt signaling transduction. In zebrafish embryos, HLY78 was shown to increase the expression of the conserved hematopoietic stem cell (HSC) markers, runx1 and cmyb. Synonyms: 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine. Grade: ≥98%. CAS No. 854847-61-3. Molecular formula: C17H17NO2. Mole weight: 267.3.
2-Chlorotrityl-Chloride-Resin is less acid-labile than Trityl Resin, and is widely used for solid phase immobilization. It has been used with the Fmoc/tBu methodology in the microwave-assisted solid phase peptide synthesis.
H-Lys(Abz)-Pro-Pro-pNA
H-Lys(Abz)-Pro-Pro-pNA is an internally quenched fluorogenic (FRET) substrate. CAS No. 219138-18-8. Molecular formula: C29H37N7O6. Mole weight: 579.65.