A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
The HslU subunit of the HslU-HslV complex functions as an ATP dependent 'unfoldase'. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolysed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. In peptidase family T1. Group: Enzymes. Synonyms: HslUV; HslV-HslU; HslV peptidase; ATP-dependent HslV-HslU proteinase; caseinolytic protease X; caseinolytic proteinase X; ClpXP ATP-dependent protease; ClpXP protease; ClpXP serine proteinase; Escherichia coli ClpXP serine proteinase; HslUV protease; HslUV proteinase; HslVU protease; HslVU proteinase; protease HslVU; proteinase HslUV. Enzyme Commission Number: EC 3.4.25.2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4375; HslU-HslV peptidase; EC 3.4.25.2; HslUV; HslV-HslU; HslV peptidase; ATP-dependent HslV-HslU proteinase; caseinolytic protease X; caseinolytic proteinase X; ClpXP ATP-dependent protease; ClpXP protease; ClpXP serine proteinase; Escherichia coli ClpXP serine proteinase; HslUV protease; HslUV proteinase; HslVU protease; HslVU proteinase; protease HslVU; proteinase HslUV. Cat No: EXWM-4375.
Hsp110-STAT3 interaction-IN-1
Row174336 (compound 29) is a potent inhibitor of Hsp110-STAT3 interaction that shows antiproliferative activity against HPAEC cell line, with the IC 50 of 22.67 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 882582-26-5. Pack Sizes: 1 mg. Product ID: HY-Q43097.
HSP70 Activator II, YM-08 ( (2Z, 5E) -3-ethyl-5- (3-methylbenzo[d]thiazol-2 (3H) -ylidene) -2- (pyridin-2-ylmethylene) thiazolidin-4-one, Heat Shock 70kD Protein Activator II, Hsp70 Chemical Co-Chaperone II, YM-08, YM08, YM8)
A cell-permeable, neutrally charged, pyridinium-to-pyridine substituted YM-01 and MKT-077 structural analog that exhibits higher HSP70-binding affinity, but reduced tau degradation-promoting potency in cultures (% degradation of p-tau/total tau = 42/64, 88/89, and 81/80 in HeLaC3 with 30uM YM-08, MKT-077, or YM-01, respectively) and weaker anti-cancer activity (IC50 against MDA-MB-231/MCF10A/MCF7 inuM = 1.4/3.0/2,2/MKT-077, 2.0/3.3/5.2/YM-01, and 8.5/7.8/10.5/YM-08 in 72h). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
HSP70-IN-1
HSP70-IN-1 is a heat shock protein (HSP) inhibitor that interferes with the formation of functional Hsp70-HOP-Hsp90 machinery, and it inhibits the growth of Kasumi-1 cells with an IC50 of 2.3 μM. Synonyms: HSP70-IN-1; HSP70 IN 1; 2-amino-N-[3-[2-(4-methylpiperazin-1-yl)-4-phenylmethoxypyrimidin-5-yl]sulfanylphenyl]acetamide; SCHEMBL1276103. CAS No. 1268273-90-0. Molecular formula: C24H28N6O2S. Mole weight: 464.58.
Hsp90-IN-17 hydrochloride
Hsp90-IN-17 (Example 5) hydrochloride is an HSP90 inhibitor that can be used in the study of proliferative diseases, such as cancer and neurodegenerative diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1253584-63-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148215A.
HSP90-IN-22
HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor with antiproliferative properties on cells with IC 50 values of 3.65 μM for MCF7 breast cancer cells and 2.71 μM for SKBr3 breast cancer cells, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 442898-75-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-153588.
Hsp990
HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (HSP90) with potential antineoplastic activity. HSP990 binds to and inhibits the activity of Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation. HSP90, upregulated in a variety of tumor cells, is a molecular chaperone that plays a key role in the conformational maturation, stability and function of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation and/or immune responses. Synonyms: NVP-HSP990; NVP HSP990; NVPHSP990; HSP 990; HSP-990. Grades: >98%. CAS No. 934343-74-5. Molecular formula: C20H18FN5O2. Mole weight: 379.39.
HspA I
One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 20-fold overdigestion with enzyme more than 90% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 1000U; 5000U. G↑CGC CGC↓G. Activity: 20000u.a./ml. Appearance: 10 X SE-buffer Y. Storage: -20°C. Form: Liquid. Source: An E.coli strain that carries the cloned HspA I gene from Haemophilus species A1. Pack: 10 mM Tris-HCl (pH 7.5); 50 mM NaCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1124RE.
Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. in addition to pegylation, activated peg derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity. Group: Poly(ethylene glycol) and poly(ethylene oxide). Alternative Names: HS-PEG-SH, Thiol-PEG-Thiol. Molecular formula: average Mn 1,500.
HS-PEG2K-NH2
Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. in addition to pegylation, activated peg derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity. Group: Poly(ethylene glycol) and poly(ethylene oxide). Alternative Names: HS-PEG-NH2. Molecular formula: average Mn 2000.
HS-PEG3500-NH2
Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. in addition to pegylation, activated peg derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity. Group: Poly(ethylene glycol) and poly(ethylene oxide). Alternative Names: HS-PEG-NH2. Molecular formula: average Mn 3500.
Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. in addition to pegylation, activated peg derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity. Group: Poly(ethylene glycol) and poly(ethylene oxide). Alternative Names: HS-PEG-NH2. Molecular formula: average Mn 5000.
HS-PEG7500-COOH
Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. in addition to pegylation, activated peg derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity. Group: Poly(ethylene glycol) and poly(ethylene oxide). Alternative Names: Thiol-PEG-Carboxyl, HS-PEG-COOH, HS-PEG-COOH. Molecular formula: average Mn 7,500.
HS-PEG7500-NH2
Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. in addition to pegylation, activated peg derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity. Group: Poly(ethylene glycol) and poly(ethylene oxide). Alternative Names: HS-PEG-NH2. Molecular formula: average Mn 7,500.
HSPyU. Group: Biochemicals. Alternative Names: Dipyrrolidino (N-succinimidyloxy) carbenium hexafluorophosphate; N,N,N',N'-Bis(tetramethylene)-O-(N-succinimidyl)uronium hexafluorophosphate; O- (N-Succinimidyl) -N, N, N', N'-bis (tetramethylene) uronium hexafluorophosphate. Grades: Highly Purified. CAS No. 207683-26-9. Pack Sizes: 25g, 50g, 100g, 250g, 500g. Molecular Formula: C13H20F6N3O3P. US Biological Life Sciences.
Worldwide
HSR6071
HSR60716071, a novel pyrazinecarboxamide derivative, exhibits potent inhibition of the IgE-mediated passive cutaneous anaphylaxis (PCA) in rats on oral administration, and that its inhibition of PCA is at least in part due to the depression of allergic histamine release from mast cells. Synonyms: 6-pyrrolidin-1-yl-N-(2H-tetrazol-5-yl)pyrazine-2-carboxamide; 6-(1-pyrrolidinyl)-N-(1H-tetrazol-5-yl)-2-pyrazinecarboxamide; HSR 6071l; HSR-6071. CAS No. 111374-21-1. Molecular formula: C10H12N8O. Mole weight: 260.26.
HSTU
HSTU. Group: Biochemicals. Alternative Names: N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate; O-(N-Succinimidyl)-N,N,N',N'-tetramethyluronium hexafluorophosphate. Grades: Highly Purified. CAS No. 265651-18-1. Pack Sizes: 50g, 100g, 250g, 500g, 1kg. Molecular Formula: C9H16F6N3O3P. US Biological Life Sciences.
Worldwide
HSV-1-amide UL 26 Open Reading Frame (242-255)
HSV-1-amide UL 26 Open Reading Frame (242-255) is a highly characteristic substrate of the herpes simplex virus type 1 protease (HSV-1), which is essential for viral nucleocapsid formation and viral replication. The C-terminal cleavage product of HTYLQASEKFKMWG-amide is detected by fluorescence detector at 280 nm (excitation) and 350 nm (emission), respectively. Synonyms: H-His-Thr-Tyr-Leu-Gln-Ala-Ser-Glu-Lys-Phe-Lys-Met-Trp-Gly-NH2; L-histidyl-L-threonyl-L-tyrosyl-L-leucyl-L-glutaminyl-L-alanyl-L-seryl-L-alpha-glutamyl-L-lysyl-L-phenylalanyl-L-lysyl-L-methionyl-L-tryptophyl-glycinamide; Glycinamide, L-histidyl-L-threonyl-L-tyrosyl-L-leucyl-L-glutaminyl-L-alanyl-L-seryl-L-α-glutamyl-L-lysyl-L-phenylalanyl-L-lysyl-L-methionyl-L-tryptophyl-. Grades: ≥95%. CAS No. 396716-24-8. Molecular formula: C80H117N21O20S. Mole weight: 1724.98.
HSV-gB2 (498-505)
HSV-gB2 (498-505) is an immunodominant epitope from herpes simplex virus (HSV) glycoprotein B residues 498-505, acts as H-2Kb-restricted and HSV-1/2-cross-reactive cytotoxic T-lymphocyte (CTL) recognition epitope [1]. Uses: Scientific research. Group: Peptides. CAS No. 149997-91-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1862.
HT-2 toxin
HT-2 toxin is a mycotoxin produced by Fusarium sp. Symptoms of poisoning are nausea, vomiting, diarrhea, and leukopenia. The acute toxicity is lower than trichothecene. Uses: This product is used as a reference standard in quantitative analysis of food stuffs. Synonyms: Mycotoxin HT 2; Toxin HT 2. CAS No. 26934-87-2. Molecular formula: C22H32O8. Mole weight: 424.48.
HT-2 Toxin
HT-2 Toxin is a trichothecene group mycotoxin. HT-2 Toxin is the 4-hydroxy analogue of T-2 Toxin which has been shown to induce DNA damage and cell death on prolonged administration. Group: Biochemicals. Alternative Names: (3α,4 β,8α)-12,13-Epoxytrichothec-9-ene-3,4,8,15-tetrol 8-(3-Methylbutanoate) 15-Acetate; 12,13-Epoxytrichothec-9-ene-3α,4 β,8α,15-tetro 15-Acetate 8-Isovalerate; 3,4-Dihydroxy-15-acetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-Δ9-trichothecene; Isovaleric Acid 8-Ester with 12,13-epoxytrichothec-9-ene-3α,4 β,8α,15-tetrol 15-Acetate; HT 2; HT 2 Toxin; Mycotoxin HT 2; NSC 278571; Toxin HT 2. Grades: Highly Purified. CAS No. 26934-87-2. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
HT-61
HT-61, also known as HY-50A, is a pyrroloquinolone antibiotic potentially for the treatment of staphylococcal infections. HT61 was effective at reducing biofilm viability and was associated with increased expression of cell wall stress and division proteins, confirming its potential as a treatment for S. aureus biofilm infections. HT61 enhances the effect of tobramycin against Pseudomonas aeruginosa in vitro and in vivo. Group: Others. Alternative Names: HT-61; HT61; HT 61; HY-50A; HY 50A; HY50A. CAS No. 936622-80-9. Molecular formula: C26H24N2O. Mole weight: 380.49. Appearance: Solid powder. Purity: >98%. IUPACName: 4-methyl-1-phenethyl-8-phenoxy-2,3-dihydro-1H-pyrrolo[3,2-c]quinoline. Canonical SMILES: CC1=NC2=CC=C (OC3=CC=CC=C3) C=C2C4=C1CCN4CCC5=CC=CC=C5. Catalog: ACM936622809.
HTBA
HTBA(3-Hydroxy-2,4,6-triiodobenzoic acid) for your research needs. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 53279-72-4. Pack Sizes: 10 mM * 1 mL; 5 g. Product ID: HY-15919.
HTH-01-015 is a potent and selective inhibitor of NUAK1 with IC50 of 100 nM, does not significantly inhibit NUAK2 (IC50 of >10 μM). Synonyms: HTH-01-015; HTH01-015; HTH 01-015; HTH-01015; HTH01015; HTH 01015. Grades: >98%. CAS No. 1613724-42-7. Molecular formula: C26H28N8O. Mole weight: 468.55.
HTH-01-015
HTH-01-015 is a potent and selective inhibitor of NUAK1 (IC50 = 100 nM) and does not affect the activity of a panel of 139 other kinases, including additional AMPK family members. The administration of HTH-01-015 to MEFs (mouse embryonic fibroblasts) significantly inhibits migration in a wound-healing assay to a similar extent as NUAK1-knockout. HTH-01-015 also inhibit proliferation of MEFs to the same extent as NUAK1 knockout and U2OS cells to the same extent as NUAK1 shRNA knockdown. HTH-01-015 impaired the invasive potential of U2OS cells in a 3D cell invasion assay to the same extent as NUAK1 knockdown. HTH-01-015 will serve as useful chemical probes to delineate the biological roles of the NUAK kinases. Group: Inhibitors. Alternative Names: HTH-01-015; HTH01-015; HTH 01-015; HTH-01015; HTH01015; HTH 01015. CAS No. 1613724-42-7. Molecular formula: C26H28N8O. Mole weight: 468.57. Appearance: Solid powder. Purity: >98%. IUPACName: 4,5,13-trimethyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5,13-dihydro-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one. Canonical SMILES: CC1=C (N (C)C (C2=CC (C=CC=C3)=C3C=C2N4C)=O)C4=NC (NC5=CN (N=C5)C6CCNCC6)=N1. Catalog: ACM1613724427.
H-Thr-asp-oh
Heterocyclic Organic Compound. Alternative Names: H-THR-ASP-OH;Thr-Asp. CAS No. 108320-97-4. Molecular formula: C8H14N2O6. Mole weight: 234.21. Catalog: ACM108320974.
H-Thr-Pro-Asn-Gln-Arg-Gln-Asn-Val-Cys-OH is a naturally presented epitope of HLA-B7 molecules recognized by CTL RP1 on the cell surface. Synonyms: L-Threonyl-L-prolyl-L-asparaginyl-L-glutaminylarginyl-L-glutaminyl-L-asparaginyl-L-valyl-L-cysteine. Grades: ≥95%. CAS No. 2022956-41-6. Molecular formula: C41H70N16O15S. Mole weight: 1059.17.
H-Thr-Pro-OH HCl
Cas No. 281670-51-7. Molecular formula: C9H17ClN2O4. Mole weight: 252.69.
H-Thr(tBu)-2-Cl-Trt Resin
Alfa Chemistry's amino acid 2-Cl-Trt resins are available in loadings ranging from 0.4 to 0.7 mmol/g. Since the linked amino acids are N-protected, these resins can be used without pretreatment. Group: Amino acid 2-cl-trt resins. Alternative Names: O-t-Butyl-L-threonine-2-chlorotrityl resin. Pack Sizes: 5g, 25g.
H-Thr(tBu)-OMe.HCl
H-Thr(tBu)-OMe.HCl is a threonine derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 71989-43-0. Pack Sizes: 10 g; 25 g; 100 g. Product ID: HY-W042013.
HTL-001 is a novel inhibitor of HOX/PBX binding. In mouse models, it inhibited the growth of prostate and breast tumor. Besides, HTL-001 can significantly increase the expression of cFos and DUSP1, which are targets of HXR9. Uses: Anti-prostate and breast tumor. Synonyms: HTL-001; HTL001.
HTL26119
HTL26119 is a glucagon-like peptide-1 receptor (GLP-1R) antagonist. Synonyms: HTL-26119; HTL 26119. Grades: ≥98% by HPLC. Molecular formula: C28H23Cl3N2O5. Mole weight: 573.85.
It is a cell penetrating peptide. Synonyms: H-Thr-Arg-Arg-Gln-Arg-Thr-Arg-Arg-Ala-Arg-Arg-Asn-Arg-OH; L-threonyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-threonyl-L-arginyl-L-arginyl-L-alanyl-L-arginyl-L-arginyl-L-asparagyl-L-arginine. Grades: ≥95%. Molecular formula: C68H131N39O18. Mole weight: 1783.05.
HTMT dimaleate
HTMT dimaleate. Group: Biochemicals. Grades: Purified. CAS No. 195867-54-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
HTMT dimaleate
HTMT dimaleate is a histamine H1 and H2 receptor agonist with 4x104 fold activity over histamine in H2-mediated effects in natural suppressor cells. HTMT dimaleate increases intracellular Ca2+ and IP3 in lymphocytes through a binding site except for H1, H2 or H3. Synonyms: 6-[2- (4-Imidazolyl) ethylamino]-N- (4-trifluoromethylphenyl) heptanecarboxamide dimaleate; Histamine trifluoromethyl toluidide. Grades: ≥99% by HPLC. CAS No. 195867-54-0. Molecular formula: C19H25F3N4O.2C4H4O4. Mole weight: 614.57.
HtrA2 peptidase
This enzyme is upregulated in mammalian cells in response to stress induced by both heat shock and tunicamycin treatment. It can induce apoptosis in a caspase-independent manner through its peptidase activity and in a caspase-dependent manner by disrupting the interaction between caspase and the inhibitor of apoptosis (IAP). Belongs in peptidase family S1C. Group: Enzymes. Synonyms: high temperature requirement protein A2; HtrA2; Omi stress-regulated endoprotease; serine proteinase OMI; HtrA2 protease; OMI/HtrA2 protease; HtrA2/Omi; Omi/HtrA2. Enzyme Commission Number: EC 3.4.21.108. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4103; HtrA2 peptidase; EC 3.4.21.108; high temperature requirement protein A2; HtrA2; Omi stress-regulated endoprotease; serine proteinase OMI; HtrA2 protease; OMI/HtrA2 protease; HtrA2/Omi; Omi/HtrA2. Cat No: EXWM-4103.
H+-transporting two-sector ATPase
A multisubunit non-phosphorylated ATPase that is involved in the transport of ions. Large enzymes of mitochondria, chloroplasts and bacteria with a membrane sector (Fo, Vo, Ao) and a cytoplasmic-compartment sector (F1, V1, A1). The F-type enzymes of the inner mitochondrial and thylakoid membranes act as ATP synthases. All of the enzymes included here operate in a rotational mode, where the extramembrane sector (containing 3 α- and 3 β-subunits) is connected via the Δ-subunit to the membrane sector by several smaller subunits. Within this complex, the γ- and ε-subunits, as well as the 9-12 c subunits rotate by consecutive 120° angles and perform...cal conditions, they pump H+ rather than synthesize ATP. Group: Enzymes. Synonyms: ATP synthase; F1-ATPase; FoF1-ATPase; H+-transporting ATPase; mitochondrial ATPase; coupling factors (F0, F1 and CF1); chloroplast ATPase; bacterial Ca2+/Mg2+ ATPase. Enzyme Commission Number: EC 7.1.2.2 (Formerly EC 3.6.3.14). Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4650; H+-transporting two-sector ATPase; EC 3.6.3.14; ATP synthase; F1-ATPase; FoF1-ATPase; H+-transporting ATPase; mitochondrial ATPase; coupling factors (F0, F1 and CF1); chloroplast ATPase; bacterial Ca2+/Mg2+ ATPase. Cat No: EXWM-4650.
Tryptophanyl-asparagine is a dipeptide composed of Tryptophan and asparagine. Synonyms: Trp-Asn. CAS No. 175027-11-9. Molecular formula: C15H18N4O4. Mole weight: 318.33.
H-Trp(Boc)-2-Cl-Trt Resin
Alfa Chemistry's amino acid 2-Cl-Trt resins are available in loadings ranging from 0.4 to 0.7 mmol/g. Since the linked amino acids are N-protected, these resins can be used without pretreatment. Group: Amino acid 2-cl-trt resins. Alternative Names: Nin-Boc-L-tryptophan-2-chlorotrityl resin. Pack Sizes: 5g, 25g.
H-Trp-Phe-Tyr-Ser(PO3H2)-Pro-Arg-pNA is the chromogenic substrate for Pin1, an important and conserved mitotic peptidyl-prolyl isomerase (PPIase) that specifically recognizes the phosphoserine-proline bonds present in mitotic phosphoproteins (kcat/Km = 20160 mM-1s-1). Synonyms: L-Argininamide, L-tryptophyl-L-phenylalanyl-L-tyrosyl-O-phosphono-L-seryl-L-prolyl-N-(4-nitrophenyl)-; L-Tryptophyl-L-phenylalanyl-L-tyrosyl-O-phosphono-L-seryl-L-prolyl-N-(4-nitrophenyl)-L-argininamide; WFY(p)SPR-pNA. CAS No. 202739-41-1. Molecular formula: C49H59N12O13P. Mole weight: 1055.05.
Heterocyclic Organic Compound. Alternative Names: [TRP63,64]-C3A (63-77);(TRP63,TRP64)-C3A (63-77);TRP-TRP-GLY-LYS-LYS-TYR-ARG-ALA-SER-LYS-LEU-GLY-LEU-ALA-ARG;WWGKKYRASKLGLAR;H-TRP-TRP-GLY-LYS-LYS-TYR-ARG-ALA-SER-LYS-LEU-GLY-LEU-ALA-ARG-OH. CAS No. 130154-64-2. Molecular formula: C86H134N26O18. Mole weight: 1820.15. Appearance: White powder. Catalog: ACM130154642.
H-Trp-Trp-Trp-OH
It is a highly hydrophobic tripeptide used as a model in phase distribution studies. Synonyms: Trp-Trp-Trp; L-Tryptophyl-L-tryptophyl-L-tryptophan; (S)-2-[(S)-2-[(S)-2-Amino-3-(1H-indol-3-yl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-3-(1H-indol-3-yl)-propionic acid. CAS No. 59005-82-2. Molecular formula: C33H32N6O4. Mole weight: 576.65.
H-Trp-Val-OH
H-Trp-Val-OH is an effective non-competitive inhibitor of xanthine oxidase, and also inhibits DPP IV, contrary to the inverse dipeptide. Synonyms: H-WV-OH; L-tryptophyl-L-valine; tryptophanyl-valine; L-Trp-L-Val-OH; (S)-2-[(S)-2-Amino-3-(1H-indol-3-yl)-propionylamino]-3-methyl-butyric acid. Grades: ≥95% by HPLC. CAS No. 24613-12-5. Molecular formula: C16H21N3O3. Mole weight: 303.35.
HTS01037
HTS01037, a high-affinity ligand of adipocyte fatty acid binding protein (A-FABP/aP2) (Ki = 0.67 μM), and is a competitive antagonist of protein-protein interactions mediated by AFABP/aP2 (Ki= 0.67 μM). Synonyms: HTS01037; HTS 01037; HTS-01037. 4-[(2-methoxycarbonyl-5-thiophen-2-ylthiophen-3-yl)amino]-4-oxobut-2-enoic acid; (E)-4-[(2-methoxycarbonyl-5-thiophen-2-ylthiophen-3-yl)amino]-4-oxobut-2-enoic acid; 4-{[2-(methoxycarbonyl)-5-(2-thienyl)-3-thienyl]amino}-4-oxo-2-butenoic acid. CAS No. 682741-29-3. Molecular formula: C14H11NO5S2. Mole weight: 337.37.
Heterocyclic Organic Compound. Alternative Names: H-TYR-PRO-PRO-TRP-OH. CAS No. 122409-34-1. Molecular formula: C30H35N5O6. Mole weight: 561.63. Catalog: ACM122409341.
H-Tyr(tBu)-2-Cl-Trt Resin
Alfa Chemistry's amino acid 2-Cl-Trt resins are available in loadings ranging from 0.4 to 0.7 mmol/g. Since the linked amino acids are N-protected, these resins can be used without pretreatment. Group: Amino acid 2-cl-trt resins. Alternative Names: O-t-Butyl-L-tyrosine-2-chlorotrityl resin. Pack Sizes: 5g, 25g.