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| Product | Description | |
|---|---|---|
| Histone H4 (1-103) human | recombinant, expressed in E. coli, ?95% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. |  |
| Histone H4 (2-58) human | recombinant, expressed in E. coli, ?70% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Histone H4 full length human | recombinant, expressed in E. coli, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Histone H4 peptide (1-21), biotin | ?90% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Histone H4 peptide (1-21) human | ?90% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Histone H4 peptide (Di-methylated R3), biotin | ?90% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Histone Lysine Demethylase Inhibitor IX, PBIT (2-(4-Methylphenyl)-1,2-benzisothiazol-3(2H)-one, JHDM Inhibitor V) | A cell-permeable iron chelating benzisothiazolone compound with microbicide and fungicide properties that acts as a potent, selective, and reversible inhibitor of Jumonji AT-Rich Interactive Domain 1 (JARID1) histone demethylases (IC50 = 3uM for JARID1B). Also blocks the activity of other related demethylases at higher concentration (IC50 = 6, 4.9, and 28uM for JARID1A, JARID1C, and JMJD2E, respectively). However, it does affect the activity of unrelated UTX and JMJD3 H3K27me3 demethylases. HeLa cells overexpressing full length JARID1B show a significant reduction in H3K4Me3 activity following PBIT treatment (~10uM). Blocks the proliferation of UACC-812 tumor cells expressing higher levels of JARDID1B, but does not significantly affect MCF7 or MCF10A cells expressing lower levels of JARDID1B. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??NOS, Primary Target: JARID1 Histone Demethylases. US Biological Life Sciences. |  Worldwide |
| Histone Lysine Demethylase Inhibitor VII, GSK-J1 (3-(6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-ylamino)propanoic Acid, JHDM Inhibitor II) | A pyridinyl -pyrimidinyl aminopropanoic acid that effectively inhibits KDM6 family H3K27m3 demethylases JMJD3 and UTX (IC50 = 18 and 56uM, respectively, by MALDI Mass detection) in an alpha-ketoglutarate-competitive, peptide substrate-non-competitive manner, displaying much reduced potency against JARID1C, JMJD1a, JMJD2a, JMJD2c, JMJD2d, JMJD2e, as well as112 kinases and 60 non-kinase enzymes. Recommended for cell-free assays only. For culture treatment, use the cell-permeable pro-drug GSK-J4. Group: Biochemicals. Grades: Highly Purified. CAS No. 1373422-53-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Histone Lysine Demethylase Inhibitor VIII, GSK-J4 (Ethyl-3-(6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-ylamino)propanoate, GSK-J1 Pro-Drug, JHDM Inhibitor II Pro-Drug) | A cell-permeable GSK-J1 prodrug that is ineffective in cell-free assays, but is effectively converted to GSK-J1 intracellularly for effective JMJD3 and UTX inhibition (effective conc. 25 to 50uM in HeLa cultures). GSK-J4 treatment is shown to block LPS-induced TNF-alpha production in primary human macrophage cultures (IC50 = 9uM by ELISA). Group: Biochemicals. Grades: Highly Purified. CAS No. 1373423-53-0. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?, Primary Target: H3K27me3 demethylases JMJD3 & UTX. US Biological Life Sciences. | Worldwide |
| histone-lysine N-methyltransferase | One of a group of enzymes methylating proteins; see also EC 2.1.1.59, [cytochrome-c]-lysine N-methyltransferase and EC 2.1.1.60, calmodulin-lysine N-methyltransferase. Group: Enzymes. Synonyms: protein methylase III; protein methylase 3; protein (lysine) methyltransferase; protein methyltransferase II; protein-lysine N-methyltransferase; histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase; S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase. Enzyme Commission Number: EC 2.1.1.43. CAS No. 9055-8-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1947; histone-lysine N-methyltransferase; EC 2.1.1.43; 9055-08-7; protein methylase III; protein methylase 3; protein (lysine) methyltransferase; protein methyltransferase II; protein-lysine N-methyltransferase; histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase; S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase. Cat No: EXWM-1947. |  |
| Histone-lysine N-methyltransferase EZH2 (120-128) | Histone-lysine N-methyltransferase EZH2 (120-128) is a bioactive peptide of Histone-lysine N-methyltransferase EZH2. Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. Synonyms: ENX-1 (120-128); Enhancer of zeste homolog 2 (120-128); Lysine N-methyltransferase 6 (120-128). |  |
| Histone-lysine N-methyltransferase EZH2 (165-174) | Histone-lysine N-methyltransferase EZH2 (165-174) is a bioactive peptide of Histone-lysine N-methyltransferase EZH2. Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. Synonyms: ENX-1 (165-174); Enhancer of zeste homolog 2 (165-174); Lysine N-methyltransferase 6 (165-174). | |
| Histone-lysine N-methyltransferase EZH2 (291-299) | Histone-lysine N-methyltransferase EZH2 (291-299) is a bioactive peptide of Histone-lysine N-methyltransferase EZH2. Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. Synonyms: ENX-1 (291-299); Enhancer of zeste homolog 2 (291-299); Lysine N-methyltransferase 6 (291-299). | |
| Histone-lysine N-methyltransferase EZH2 (735-743) | Histone-lysine N-methyltransferase EZH2 (735-743) is a bioactive peptide of Histone-lysine N-methyltransferase EZH2. Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. Synonyms: ENX-1 (735-743); Enhancer of zeste homolog 2 (735-743); Lysine N-methyltransferase 6 (735-743). | |
| Histone Methyltransferase EZH2 Inhibitor, DZNep (3-deazaneplanocin A, HCl, (1S, 2R, 5R) -5- (4-amino-1H-imidazo[4, 5-c]pyridin-1-yl) -3- (hydroxymethyl) cyclopent-3-ene-1, 2-diol, HCl, HMTase Inhibitor X) | A cell-permeable compound that is shown (at 1uM concentrations) to inhibit EZH2-mediated trimethylation of K27 on histone H3 and induces the expression of cell-cycle regulatory genes, p21 and p27, as well as the cell death regulator, FBXO32, in OCI-AML3 and HL-60 cells, whereby treatment with inhibitor increases p16 levels in the former, but not the latter of the two cultures. At concentrations between 200nM and 2000nM, this compound is found to dose-dependently deplete the expression of polycomb group proteins EZH2, SUZ12, and EED in cultured and primary AML cell extracts. At concentrations up to ≥ 1000nM, DZNep dose-dependently increases the percentage of apoptotic cells up to > ~ 38%, with greater potency against OCI-AML3 than HL-60 cultures and inhibits colony growth up to > ~ 85% for both cell lines. In OCI-AML3 cultures, 1000nM of treatment demonstrates a significant increase in the accumulation of cells in the G0/G1 phase (58.5%) with a concomitant decrease in the number of c Group: Biochemicals. Grades: Highly Purified. CAS No. 102052-95-9. Pack Sizes: 2mg. Molecular Formula: C??H??N?O?; HCl; H?O. US Biological Life Sciences. | Worldwide |
| Histone Modification Compound Library | A unique collection of 362 histone modification related compounds for high throughput screening (HTS) and high content screening (HCS); - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L3500. Categories: Histone Modification Compounds Libraries. |  |
| Histone Octamer full length human | recombinant, expressed in E. coli, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Histrelin acetate | Histrelin acetate, a GnRH analogue, is a GnRH Receptor agonist. Histrelin acetate increases serum luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone levels. Histrelin acetate can be used in the research of prostate cancer, endometriosis [1] [2] [5]. Uses: Scientific research. Group: Peptides. CAS No. 220810-26-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0056A. |  |
| His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt | His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt. Synonyms: L-Histidyl-L-Tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide; H-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt; L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-L-proline ethylamide. Grade: ≥95%. CAS No. 1642799-35-6. Molecular formula: C54H79N15O10. Mole weight: 1098.32. | |
| His-Val-OH | His-Val-OH. Group: Biochemicals. Grades: Highly Purified. CAS No. 76019-15-3. Pack Sizes: 100mg, 250mg. US Biological Life Sciences. | Worldwide |
| His-Val-OH 98+% (TLC) | His-Val-OH 98+% (TLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| Hitachimycin | Hitachimycin is a macrolide antibiotic produced by Streptomyces No. KG-2245. It can inhibit tumor cell growth and antiprotozoal effects. Synonyms: Stubomycin. Grade: 95%. CAS No. 77642-19-4. Molecular formula: C29H35NO5. Mole weight: 477.59. | |
| HITCI | HITCI. Group: other materials. Alternative Names: Hexacyanine3, HITCiodide, HTCiodide, LC8500, 1, 1', 3, 3, 3', 3'-Hexa methyl indotricarbocyanineiodide, 2- [7- (1, 3-Dihydro-1, 3, 3-tri methyl -2H-indol-2-ylidene) -1, 3, 5-heptatrienyl] -1, 3, 3-tri methyl -3H-indoliumiodide. CAS No. 19764-96-6. Product ID: 1,3,3-trimethyl-2-[7-(1,3,3-trimethylindol-1-ium-2-yl)hepta-2,4,6-trienylidene]indole; iodide. Molecular formula: 536.49. Mole weight: C29H33IN2. CC1 (C2=CC=CC=C2[N+] (=C1C=CC=CC=CC=C3C (C4=CC=CC=C4N3C) (C)C)C)C. [I-]. InChI=1S/C29H33N2. HI/c1-28 (2)22-16-12-14-18-24 (22)30 (5)26 (28)20-10-8-7-9-11-21-27-29 (3, 4)23-17-13-15-19-25 (23)31 (27)6; /h7-21H, 1-6H3; 1H/q+1; /p-1. JKXWXYURKUEZHV-UHFFFAOYSA-M. 98%+. |  |
| HITC perchlorate | HITC perchlorate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3,3-trimethyl-rienyl]-perchlorate;3h-indolium,2-[7-(1,3-dihydro-1,3,3-trimethyl-2h-indol-2-ylidene)-1,3,5-heptat;HITCP;1,1',3,3,3',3'-HEXAMETHYLINDOTRICARBOCYANINE PERCHLORATE;1,1',3,3,3',3'-HEXAMETHYL-2,2'-INDOTRICARBOCYANINE PERCHLORATE;3H-INDOLIUM, 1. Product Category: Photonic and Optical Device. CAS No. 16595-48-5. Molecular formula: C29H33ClN2O4. Mole weight: 509.04. Product ID: ACM16595485. Alfa Chemistry ISO 9001:2015 Certified. Categories: EINECS 240-652-5. |  |
| HI TOPK 032 | HI TOPK 032. Group: Biochemicals. Grades: Purified. CAS No. 487020-03-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| HI TOPK 032 | HI TOPK 032 is a novel TOPK inhibitor as a T-LAK-cell-originated protein kinase (TOPK) inhibitor, blocking phosphorylation of the substrate histone H2AX with an IC50 value of ~2 μM and providing complete inhibition at 5 μM. Uses: A novel topk inhibitor. Synonyms: HI-TOPK-032; HI-TOPK032; HI-TOPK 032. N-(12-Cyanoindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxamide. Grade: ≥98%. CAS No. 487020-03-1. Molecular formula: C20H11N5OS. Mole weight: 369.4. | |
| HI-TOPK-032 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| HIV-1 gag | ?95% (SDS-PAGE), recombinant, expressed in E. coli, Galactosidase-tagged. Group: Fluorescence/luminescence spectroscopy. | |
| HIV-1 gag Protein p24 (194-210) | HIV-1 gag Protein p24 (194-210). Synonyms: H-Ala-Asn-Pro-Asp-Cys-Lys-Thr-Ile-Leu-Lys-Ala-Leu-Gly-Pro-Ala-Ala-Thr-OH; L-alanyl-L-asparagyl-L-prolyl-L-alpha-aspartyl-L-cysteinyl-L-lysyl-L-threonyl-L-isoleucyl-L-leucyl-L-lysyl-L-alanyl-L-leucyl-glycyl-L-prolyl-L-alanyl-L-alanyl-L-threonine; L-Threonine, L-alanyl-L-asparaginyl-L-prolyl-L-α-aspartyl-L-cysteinyl-L-lysyl-L-threonyl-L-isoleucyl-L-leucyl-L-lysyl-L-alanyl-L-leucylglycyl-L-prolyl-L-alanyl-L-alanyl-. Grade: ≥95%. CAS No. 141281-67-6. Molecular formula: C73H126N20O23S. Mole weight: 1683.99. | |
| HIV-1 GP120 protein | recombinant, expressed in HEK 293 cells. Group: Fluorescence/luminescence spectroscopy. | |
| HIV-1 inhibitor-10 | HIV-1 inhibitor-10 is a nanomolar HIV-1 maturation inhibitor. Synonyms: 2-[(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-carboxy-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-1,2,3,4,5,6,7,7a,11,11b,12,13,13a,13b-tetradecahydrocyclopenta[a]chrysen-9-yl]spiro[3.3]hept-2-ene-6,6-dicarboxylic acid; 6-[28-Hydroxy-28-oxolupa-2,20(29)-dien-3-yl]spiro[3.3]hept-5-ene-2,2-dicarboxylic acid. Grade: ≥98% (HPLC). CAS No. 1449660-81-4. Molecular formula: C39H54O6. Mole weight: 618.84. | |
| HIV-1 inhibitor-3 | HIV-1 inhibitor-3 is an inhibitor of HIV infection. (Extracted from patent US2018360927). Synonyms: 1-((2R,3R,4S,5S)-3,5-Difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 1-(2-Deoxy-2,4-difluoro-beta-D-ribofuranosyl)uracil; Uridine, 2'-deoxy-2'-fluoro-4'-C-fluoro-. Grade: ≥95%. CAS No. 1612841-22-1. Molecular formula: C9H10F2N2O5. Mole weight: 264.18. | |
| HIV-1 inhibitor-6 | HIV-1 inhibitor-6 (compound 9), a diheteroarylamide-based compound, is a potent HIV-1 pre-mRNA alternative splicing inhibitor. HIV-1 inhibitor-6 blocks HIV replication. HIV-1 inhibitor-6 is active against wild-type HIV-1IIIB (subtype B, X4-tropic) and HIV-1 97USSN54 (subtype A, R5-tropic) with EC 50 s of 0.6 μM and 0.9 μM, respectively. HIV-1 inhibitor-6 inhibits HIV strains resistant to agents targeting HIV reverse transcriptase, protease, integrase, and coreceptor CCR5 with EC 50 s ranging from 0.9 to 1.5 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1821309-39-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134851. | |
| HIV-1 inhibitor-60 | GSK2838232 is a novel human immune virus (HIV) maturation inhibitor being developed for the treatment of chronic HIV infection. GSK2838232 is a betulin derivative. Synonyms: 1443461-21-9; HIV-1 inhibitor-60; HIV Inhibitor GSK2838232; SCHEMBL15038672; EX-A202; HIV Inhibitor GSK2838232?; BDBM271422; BCP07297; US10064873, Example 45; GSK 2838232; AC-33624; HY-108255; CS-0027803; A926344; 4- (((3aR,5aR,5bR,7aR, 9S,11aR,11bR,13aS)- 3a-((R)-2-((3- Chlorobenzyl)(2- (dimethylamino)ethyl) amino)-1-hydroxyethyl)- 1-isopropyl- 5a,5b,8,8,11a- pentamethyl-2-oxo- 3,3a,4,5,5a,5b,6,7. Grade: 98%. CAS No. 1443461-21-9. Molecular formula: C48H73ClN2O6. Mole weight: 809.56. | |
| HIV-1 inhibitor-8 | HIV-1 inhibitor-8 is a potent, low-toxic and orally active HIV - 1 non-nucleoside reverse transcriptase inhibitor (NNRTI) with an IC50 of 0.081 μM against WT HIV-1 reverse transcriptase. It has particularly strong antiviral activity with EC50s of 4.44-54.5 nM against various HIV-1 strains. Synonyms: (E)-4-((4-(4-(2-cyanovinyl)-2,6-dimethylphenoxy)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-yl)amino)benzonitrile. Molecular formula: C25H21N5OS. Mole weight: 439.53. | |
| HIV-1 inhibitor-9 | HIV-1 inhibitor-9 is a potent inhibitor against the wild-type (WT) HIV-1 strains or multiple NNRTI-resistant strains at low nanomolar levels. Synonyms: CHEMBL4875519|HIV-1 inhibitor-9|BDBM50575074|CS-0226407. Grade: ≥98% (HPLC). CAS No. 2708201-36-7. Molecular formula: C24H21N5O. Mole weight: 395.46. | |
| HIV-1 integrase inhibitor | HIV-1 integrase inhibitor is uesful for anti-HIV, which can target HIV-1 integrase and depress the activity in the treatment of HIV infection, AIDS, and other similar diseases characterized by integration of a retroviral genome into a host chromosome. Synonyms: (Z)-4-(3-(azidomethyl)phenyl)-2-hydroxy-4-oxobut-2-enoic acid. Grade: >98%. CAS No. 544467-07-4. Molecular formula: C11H9N3O4. Mole weight: 247.21. | |
| HIV-1 integrase inhibitor | HIV-1 integrase inhibitor is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 544467-07-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13025. | |
| HIV-1 integrase inhibitor 2 | HIV-1 integrase inhibitor 2 is useful for anti-HIV, which can target HIV-1 integrase and depress the activity in the treatment of HIV infection, AIDS, and other similar diseases characterized by integration of a retroviral genome into a host chromosome. It did not affect integrase-DNA binding and only weakly inhibited the catalytic activities of integrase. Synonyms: CX04328; CX-04328; CX 04328; 3-Quinolineacetic acid, 6-chloro-2-methyl-4-phenyl-a-propyl-. Grade: >98%. CAS No. 957890-42-5. Molecular formula: C21H20ClNO2. Mole weight: 353.84. | |
| HIV-1 integrase inhibitor 3 | HIV-1 integrase inhibitor 3 is an HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 2.7 nM. Synonyms: 1,8-Naphthyridine-3-carboxamide, 4-amino-N-[(2,4-difluorophenyl)methyl]-1,2-dihydro-1-hydroxy-6-(5-hydroxypentyl)-2-oxo-; 4-Azanyl-N-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-6-(5-oxidanylpentyl)-1,8-naphthyridine-3-carboxamide; 4-Amino-N-(2,4-difluorobenzyl)-1-hydroxy-6-(5-hydroxypentyl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide. Grade: ≥95%. CAS No. 1638504-56-9. Molecular formula: C21H22F2N4O4. Mole weight: 432.42. | |
| HIV-1 integrase inhibitor 4 | HIV-1 integrase inhibitor 4 is an HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 3.7 nM. Synonyms: 1,8-Naphthyridine-3-carboxamide, 4-amino-N-[(2,4-difluorophenyl)methyl]-1,2-dihydro-1-hydroxy-2-oxo-6-[2-(phenylsulfonyl)ethyl]-; 4-Azanyl-N-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-6-[2-(phenylsulfonyl)ethyl]-1,8-naphthyridine-3-carboxamide; 4-Amino-N-(2,4-difluorobenzyl)-1-hydroxy-2-oxo-6-[2-(phenylsulfonyl)ethyl]-1,2-dihydro-1,8-naphthyridine-3-carboxamide. Grade: ≥95%. CAS No. 1638504-66-1. Molecular formula: C24H20F2N4O5S. Mole weight: 514.50. | |
| HIV-1 Nef-IN-1 | HIV-1 Nef-IN-1, an inhibitor of HIV-1 Nef protein, can effectively compete for Nef-SH3Hck interactions with a Kd of 6.7 μM. Synonyms: 4-(3-Phenanthryl)butanoic acid; 3-Phenanthrenebutanoic Acid; 3-Phenanthrenebutyric Acid; NSC 92828; 3-(1-Phenanthryl)butanoic acid; 1-Phenanthrenepropanoic acid, β-methyl-. Grade: ≥95%. CAS No. 13728-56-8. Molecular formula: C18H16O2. Mole weight: 264.32. | |
| HIV-1 Protease, Recombinant | HIV-1 protease is a retroviral aspartyl protease (retropepsin) that is essential for the life-cycle of HIV. HIV protease cleaves newly synthesized viral polyproteins at the appropriate places into functional protein products as mature protein components of an infectious HIV virion. The mutation of HIV protease's active site or inhibition of its activity disrupts HIVs ability to replicate and infect additional cells. Group: Enzymes. Synonyms: HIV-1 retropepsin; HIV-1 Protease (PR); cd05482. Enzyme Commission Number: EC 3.4.23.-. Purity: > 90%. Mole weight: 38.4 kDa (1-99 aa + N-terminal GST and C-terminal Poly-his tags). It runs at ~31 kDa during SEC and SDS-PAGE analyses. Activity: > 1mU/mg. Stability: Stable for at least 6 months as supplied. It can be further diluted to 0.5-1 mg/ml with 50 mM Sodium acetate, 100 mM NaCl, 5 mM DTT, 5 mM EDTA, pH 5.0 containing 10% glycerol, and stored at -80°C in aliquots. Do not keep the enzyme at 4°C or -20°C for extended time. Avoid repeated freezing and thawing cycles. Storage: Store at -80°C. Form: Liquid. Source: E. coli. HIV-1 retropepsin; HIV-1 Protease (PR); cd05482; HIV1 protease. Cat No: NATE-1662. | |
| HIV-1 retropepsin | Present in human immunodeficiency virus type 1. Contributes to the maturation of the viral particle, and is a target of antiviral drugs. Active enzyme is a dimer of identical 11-kDa subunits. Similar enzymes occur in other retroviruses. Type example of peptidase family A2. Group: Enzymes. Synonyms: human immunodeficiency virus type 1 protease; gag protease; HIV aspartyl protease; HIV proteinase; retroproteinase; HIV-1 protease; HIV-2 protease. Enzyme Commission Number: EC 3.4.23.16. CAS No. 144114-21-6. HIV Protease. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4253; HIV-1 retropepsin; EC 3.4.23.16; 144114-21-6; human immunodeficiency virus type 1 protease; gag protease; HIV aspartyl protease; HIV proteinase; retroproteinase; HIV-1 protease; HIV-2 protease. Cat No: EXWM-4253. | |
| HIV-1 Rev 34-50 | HIV-1 Rev (34-50) is a 17-aa cell-penetrating peptide derived from HIV-1 Rev protein residue 34-50. It is an RNA-binding peptide that has been used to deliver macromolecules into cells. Synonyms: H-Thr-Arg-Gln-Ala-Arg-Arg-Asn-Arg-Arg-Arg-Arg-Trp-Arg-Glu-Arg-Gln-Arg-OH; HIV-1 Rev Protein (34-50); L-Arginine, L-threonyl-L-arginyl-L-glutaminyl-L-alanyl-L-arginyl-L-arginyl-L-asparaginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-tryptophyl-L-arginyl-L-α-glutamyl-L-arginyl-L-glutaminyl-; Revprotein (Human immunodeficiency virus 1 fragment); L-threonyl-L-arginyl-L-glutaminyl-L-alanyl-L-arginyl-L-arginyl-L-asparagyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-tryptophyl-L-arginyl-L-alpha-glutamyl-L-arginyl-L-glutaminyl-L-arginine; Rev34-50; HIV-1 Rev (34-50). Grade: ≥95%. CAS No. 141237-50-5. Molecular formula: C97H173N51O24. Mole weight: 2437.74. | |
| HIV-1 TAT (48-60) | HIV-1 TAT (48-60) is a cell-penetrating peptide generated from the human immunodeficient virus (HIV)-1 Tat protein residue 48-60. It has been used to deliver exogenous macromolecules into cells in a non-disruptive way. Synonyms: H-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Gln-OH; glycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-prolyl-L-prolyl-L-glutamine. Grade: ≥95%. Molecular formula: C70H131N35O16. Mole weight: 1719.04. | |
| HIV-1 TAT Protein Peptide | It is a cell-permeable peptide (CPP) derived from the HIV-1 tat protein transduction domain (PTD), which has been shown to promote the entry of nucleic acids into several cell types. Synonyms: HIV-1 Tat Protein (47-57); H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-OH; TAT (47-57); L-tyrosyl-glycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginine. Grade: 98%. CAS No. 191936-91-1. Molecular formula: C64H118N32O14. Mole weight: 1559.83. | |
| HIV-2 env antigen | ?95% (SDS-PAGE), recombinant, expressed in E. coli, Galactosidase-tagged. Group: Fluorescence/luminescence spectroscopy. | |
| HIV-2 Peptide | HIV-2 Peptide. Synonyms: HIV-2 env Protein gp41 (86-104); H-Lys-Asp-Gln-Ala-Gln-Leu-Asn-Ser-Trp-Gly-Cys-Ala-Phe-Arg-Gln-Val-Cys-His-Thr-OH (Disulfide bridge: Cys11-Cys17). Grade: ≥95%. CAS No. 172486-63-4. Molecular formula: C93H140N30O28S2. Mole weight: 2190.45. | |
| HIV-2 Protease, Recombinant | HIV-2 Protease, an aspartyl protease (retropepsin), is essential for the life-cycle of HIV-2 sub-type virus. It is expressed in the infected cells as a part of Gag-Pol polyprotein from which it is auto-catalytically released after formation of an immature viral particle. The enzyme subsequently cleaves the other parts of viral polyproteins resulting in the maturation of the virus. In HIV-infected patients, the enzyme is subjected to intensive mutagenesis and mutants resistant to applied medicines are produced as a result of the selection pressure. The mutation of HIV protease's active site or inhibition of its activity disrupts HIVs ability to replicate and infect additional ce...epsin; HIV-2 Protease (PR2); cd05482. Enzyme Commission Number: EC 3.4.23.-. Purity: > 85%. Mole weight: 38.3 kDa (1-99 aa + N-terminal GST and C-terminal Poly-his tags). It runs at ~31.5 kDa during SEC and SDS-PAGE analyses. Stability: Stable for at least 6 months as supplied. It can be further diluted to 0.5-1 mg/ml with 50 mM Sodium acetate, 100 mM NaCl, 5 mM DTT, 5 mM EDTA, pH 5.0 containing 10% glycerol, and stored at -80°C in aliquots. Do not keep the enzyme at 4°C or -20°C for extended time. Avoid repeated freezing and thawing cycles. Storage: Store at -80°C. Form: Liquid. Source: E. coli. HIV-2 retropepsin; HIV-2 Protease (PR2); cd05482; HIV2 protease. Cat No: NATE-1661. | |
| HIV-2 retropepsin | In peptidase family A2. Responsible for the post-translational processing of the human immunodeficiency virus polyprotein. Group: Enzymes. Enzyme Commission Number: EC 3.4.23.47. CAS No. 144114-21-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4284; HIV-2 retropepsin; EC 3.4.23.47; 144114-21-6. Cat No: EXWM-4284. | |
| H-Iva-Ome HCl | H-Iva-Ome HCl. Synonyms: (S)-Methyl 2-amino-2-methylbutanoate hydrochloride; (S)-2-amino-2-methylbutyric acid methyl ester hydrochloride; H Iva Ome HCl. Grade: 95%. CAS No. 92760-72-0. Molecular formula: C6H14ClNO2. Mole weight: 167.63. | |
| Hivernal® Neo | Hivernal® Neo. CAS No. 300371-33-9. Kosher: Y. VIGON Item # 508452. Categories: Speciality Ingrdients Suppliers, Fragrances, Perfumers. |  America & Internationally |
| HIV gag peptide 197-205 | HIV gag peptide 197-205 is an H-2Kd-restricted epitope consisting of amino acids 197-205 derived from the p24 portion of HIV-1 gag protein. Synonyms: H-Ala-Met-Gln-Met-Leu-Lys-Glu-Thr-Ile-OH; L-alanyl-L-methionyl-L-glutaminyl-L-methionyl-L-leucyl-L-lysyl-L-alpha-glutamyl-L-threonyl-L-isoleucine. Grade: ≥95%. CAS No. 214978-47-9. Molecular formula: C45H81N11O14S2. Mole weight: 1064.32. | |
| Hiv(gp120)antigenic peptide | Hiv(gp120)antigenic peptide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CYS-GLY-LYS-ILE-GLU-PRO-LEU-GLY-VAL-ALA-PRO-THR-LYS-ALA-LYS-ARG-ARG-VAL-VAL-GLN-ARG-GLU-LYS-ARG;HIV (GP120) ANTIGENIC PEPTIDE;H-CYS-GLY-LYS-ILE-GLU-PRO-LEU-GLY-VAL-ALA-PRO-THR-LYS-ALA-LYS-ARG-ARG-VAL-VAL-GLN-ARG-GLU-LYS-ARG-OH. Product Category: Heterocyclic Organic Compound. CAS No. 198636-94-1. Molecular formula: C117H211N41O31S. Mole weight: 2720.25. Product ID: ACM198636941. Alfa Chemistry ISO 9001:2015 Certified. | |
| HIV-IN-6 | HIV-IN-6 is a HIV-1 viral replication inhibitor by targeting Src family kinases (SFK) that interact with Nef protein of the virus, such as Hck [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 301357-74-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-147314. | |
| HIV-IN-8 | HIV-IN-8 is a HIV inhibitor. Synonyms: (2R)-2-(3-{[(1R)-2-(3,4-Dihydroxyphenyl)-1-carboxyethyl]oxycarbonyl}(4S,3R)-4-(3,4-dihydroxyphenyl)-6,7-dihydroxy(2-3,4-dihydronaphthylcarbonyloxy))-3-(3,4-dihydroxyphenyl)propanoic acid; (2R)-3-(3,4-dihydroxyphenyl)-2-[(1S,2R)-1-(3,4-dihydroxyphenyl)-3-[(1R)-1-[(3,4-dihydroxyphenyl)methyl]-2-hydroxy-2-oxo-ethoxy]carbonyl-6,7-dihydroxy-1,2-dihydronaphthalene-2-carbonyl]oxy-propanoic acid. CAS No. 130286-75-8. Molecular formula: C36H30O16. Mole weight: 718.61. | |
| HIV inhibitor 18A | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| HIV-IN petide | Arg-Val-Leu-(R)-Phe-Glu-Ala-Nle-NH2 contains a reduced peptide bond and is a competitive inhibitor of the HIV-1 protease with a Ki of 50 nM. Synonyms: 167875-35-6; HIV-IN petide; H-Arg-Val-Leu-psi(CH2NH)Phe-Glu-Ala-Nle-NH2; (4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentyl]amino]-3-phenylpropanoyl]amino]-5-[[(2S)-1-[[(2S)-1-amino-1-oxohexan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid; Arg-Val-Leu-(R)-Phe-Glu-Ala-Nle-NH2; 107475-09-2; N-[(2r)-2-({n~5~-[amino(Iminio)methyl]-L-Ornithyl-L-Valyl}amino)-4-Methylpentyl]-L-Phenylalanyl-L-Alpha-Glutamyl-L-Alanyl-L-Norleucinamide; 2aoe; 0Q4; Peptide Inhibitor CA/p2; N-1270; R-V-L-r-F-E-A-Nle; BDBM13935; HY-P4543; MFCD00237446; H-Arg-Val-Leu-r-Phe-Glu-Ala-Nle-NH2; DA-53842; CS-0655006; (4S)-4-[(2S)-2-{[(2S)-2-[(2S)-2-[(2S)-2-amino-5-carbamimidamidopentanamido]-3-methylbutanamido]-4-methylpentyl]amino}-3-phenylpropanamido]-4-{[(1S)-1-{[(1S)-1-carbamoylpentyl]carbamoyl}ethyl]carbamoyl}butanoic acid. Grade: ≥95%. CAS No. 167875-35-6. Molecular formula: C40H69N11O8. Mole weight: 832.04. | |
| HIV p17 Gag 77-85 | HIV p17 Gag 77-85 is used in the research of anti-HIV. Synonyms: HIV-1 gag Protein p17 (76-84); H-Ser-Leu-Tyr-Asn-Thr-Val-Ala-Thr-Leu-OH; L-seryl-L-leucyl-L-tyrosyl-L-asparagyl-L-threonyl-L-valyl-L-alanyl-L-threonyl-L-leucine; HIV P17 GAG (77-85). Grade: ≥95%. CAS No. 147468-65-3. Molecular formula: C44H72N10O15. Mole weight: 981.10. | |
| HIV Protease Fluorescent Substrate | Ex: 320nm, Em: 420nm. Group: Fluorescence/luminescence spectroscopy. | |
| HIV Protease Mutant, Recombinant | HIV-1 protease is a retroviral aspartyl protease (retropepsin) that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins at the appropriate places to create the mature protein components of an infectious HIV virion. Without effective HIV protease, HIV virions remain uninfectious. Thus, mutation of HIV protease's active site or inhibition of its activity disrupts HIVs ability to replicate and infect additional cells, making HIV protease inhibition the subject of considerable pharmaceutical research. Group: Enzymes. Synonyms: human immunodeficiency virus type 1 protease; gag protease; HIV aspartyl protease; HIV proteinase; retroproteinase; HIV-1 protease; HIV-2 protease; HIV-1 retropepsin; HIV Protease Mutant; EC 3.4.23.16. Enzyme Commission Number: EC 3.4.23.16. CAS No. 144114-21-6. HIV Protease. Mole weight: mol wt ~10.8 kDa. Storage: -70°C. Form: Supplied as a solution in 0.5M Sodium Acetate, pH 4.7with 50mM Tris-HCL, 1M NaCL, 1mM EDTA, 5mM DTT and 15% glycerol. Source: E. coli. human immunodeficiency virus type 1 protease; gag protease; HIV aspartyl protease; HIV proteinase; retroproteinase; HIV-1 protease; HIV-2 protease; HIV-1 retropepsin; HIV Protease Mutant; EC 3.4.23.16. Pack: 100 unit vial containing > 100ug protein. Cat No: NATE-0344. | |
| HIV Protease Substrate V | >98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| HIV Protease Substrate VI | HIV Protease Substrate VI is a sensitive chromogenic substrate for both HIV-1 and HIV-2 proteases. Synonyms: H-Arg-Val-Nle-p-nitro-Phe-Glu-Ala-Nle-NH2; L-arginyl-L-valyl-L-norleucyl-4-nitro-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide; L-Norleucinamide, L-arginyl-L-valyl-L-norleucyl-4-nitro-L-phenylalanyl-L-α-glutamyl-L-alanyl-. Grade: ≥95%. CAS No. 130877-92-8. Molecular formula: C40H66N12O11. Mole weight: 891.04. | |
| HJC-0123 | HJC-0123 is a potent and selective STT 3 inhibitor. HJC0123 has demonstrated to inhibit STAT3 promoter activity, downregulate phosphorylation of STAT3, increase the expression of cleaved caspase-3, inhibit cell cycle progression and promote apoptosis in breast and pancreatic cancer cells with low micromolar to nanomolar IC50 values. Furthermore, HJC-0123 significantly suppressed estrogen receptor (ER)-negative breast cancer MDA-MB-231 xenograft tumor growth in vivo (p.o.), indicating its great potential as an efficacious and orally bioavailable drug candidate for human cancer therapy. Synonyms: HJC 0123; HJC0123; 2-Phenyl-quinoline-4-carboxylic acid (1,1-dioxo-1H-1lambda6-benzo[b]thiophen-6-yl)-amide. Grade: 98%. CAS No. 1430420-02-2. Molecular formula: C24H16N2O3S. Mole weight: 412.46. | |
| HJC0152 | HJC0152 is a signal transducer and activator of transcription 3 (STAT3) inhibitor against human head and neck squamous cell carcinoma (HNSCC). Uses: Designed for use in research and industrial production. Additional or Alternative Names: HJC0152; HJC 0152; HJC-0152. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1420290-99-8. Molecular formula: C15H14Cl3N3O4. Mole weight: 406.64. Purity: >98%. IUPACName: 2-(2-Amino-ethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide Hydrochloride. Canonical SMILES: O=C(NC1=CC=C([N+]([O-])=O)C=C1Cl)C2=CC(Cl)=CC=C2OCCN.[H]Cl. Product ID: ACM1420290998. Alfa Chemistry ISO 9001:2015 Certified. | |
| HJC0152 | HJC0152 is a signal transducers and activators of transcription 3 ( STAT3 ) inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 1420290-99-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100602. | |
| HJC0152 | HJC0152 Inhibitor. Uses: Scientific use. Product Category: T4234. CAS No. 1420290-99-8. | |
| HJC0197 | HJC0197 is an erythromycin propionate-N-acetylcysteinate inhibitor (EPAC) with IC50 value of 5.9 μM for Epac2. HJC0197 can inhibit Epac1-mediated Rap1-GDP exchange activity at 25 μM, but it has no effect on cAMP-induced type I and II PKA activity at this concentration. HJC0197 can be used to study the role of Epac signaling in chondrogenesis in chicken micromass cultures. EPAC inhibitor may prevent pancreatic cancer cell migration and invasion. Uses: Study the role of epac signaling. Synonyms: HJC-0197; HJC 0197; 4-cyclopentyl-2-((2,5-dimethylbenzyl)thio)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile. Grade: 98%. CAS No. 383539-73-8. Molecular formula: C19H21N3OS. Mole weight: 339.45. | |
| HJC0350 | HJC0350 is a potent and Epac2-specific inhibitor with IC50 of 0.3 μM, exhibiting no inhibition on Epac1. Synonyms: HJC 0350; HJC-0350; 1-(mesitylsulfonyl)-2,4-dimethyl-1H-pyrrole. Grade: >98%. CAS No. 885434-70-8. Molecular formula: C15H19NO2S. Mole weight: 277.38. | |
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