A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
2-Chlorotrityl-Chloride-Resin is less acid-labile than Trityl Resin, and is widely used for solid phase immobilization. It has been used with the Fmoc/tBu methodology in the microwave-assisted solid phase peptide synthesis.
H-Ser(Trt)-2-Cl-Trt Resin
Alfa Chemistry's amino acid 2-Cl-Trt resins are available in loadings ranging from 0.4 to 0.7 mmol/g. Since the linked amino acids are N-protected, these resins can be used without pretreatment. Group: Amino acid 2-cl-trt resins. Alternative Names: O-Trityl-L-serine-2-chlorotrityl resin. Pack Sizes: 5g, 25g.
H-Ser-tyr-gly-leu-arg-pro-gly-nh2. Uses: Designed for use in research and industrial production. Additional or Alternative Names: LH-RH Fragment 4-10, Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, Luteinizing hormone releasing hormone Fragment 4-10, AC1N71DH, SureCN11884805, L5387_SIGMA, 1-[2-[[2-[[2-[[2-[(2-amino-3-hydroxypropanoyl)amino]-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]-N-(2-amino-2-oxoethyl)pyrrolidine-2-carboxamide, 51776-33-1. Product Category: Heterocyclic Organic Compound. CAS No. 51776-33-1. Molecular formula: C33H53N11O9. Mole weight: 747.84. Purity: 0.96. IUPACName: 1-[2-[[2-[[2-[[2-[(2-amino-3-hydroxypropanoyl)amino]-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]-N-(2-amino-2-oxoethyl)pyrrolidine-2-carboxamide. Canonical SMILES: CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NCC(=O)N)NC(=O)CNC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CO)N. Product ID: ACM51776331. Alfa Chemistry ISO 9001:2015 Certified.
H-SER-TYR-OH
H-SER-TYR-OH. Synonyms: Ser-Tyr; L-seryl-L-tyrosine; Serinyltyrosine; SY dipeptide; L-Ser-L-Tyr; Serine Tyrosine dipeptide. CAS No. 21435-27-8. Molecular formula: C12H16N2O5. Mole weight: 268.27.
H-Ser-tyr-ser-met-glu-his-phe-arg-trp-gly-lys-pro-val-nh2. Uses: Designed for use in research and industrial production. Additional or Alternative Names: des-Ac-|A-Melanocyte Stimulating Hormone; SYSMEHFRWGKPV-NH2. Product Category: Heterocyclic Organic Compound. CAS No. 53697-27-1. Molecular formula: C75H107N21O18S. Mole weight: 1622.85. Purity: 0.96. IUPACName: SYSMEHFRWGKPV amide. Canonical SMILES: CC(C)C(C(=O)N)NC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)CNC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CC5=CNC=N5)NC(=O)C(CCC(=O)O)NC(=O)C(CCSC)NC(=O)C(CO)NC(=O)C(CC6=CC=C(C=C6)O)NC(=O)C(CO)N. Product ID: ACM53697271. Alfa Chemistry ISO 9001:2015 Certified.
HSF1A
HSF1A is a cell-permeable human heat shock factor protein (HSP1) activator. Synonyms: 4-Ethyl-N-(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-5-yl)benzenesulfonamide. Grade: 99%. CAS No. 1196723-93-9. Molecular formula: C21H19N3O2S2. Mole weight: 409.52.
HSF1A
HSF1A is a cell-permeable activator of heat shock transcription factor 1 (HSF1)[1]. HSF1A also acts as a specific inhibitor of TRiC/CCT. Chaperonin TCP-1 ring complex (TRiC)/chaperonin containing TCP-1 (CCT) plays a pivotal role in toxin translocation and/or refolding[4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1196723-93-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103000.
HSF1B
HSF1B is a human heat shock factor protein (HSF1) activator. Synonyms: N-[2,5-bis(4-chlorophenyl)pyrazol-3-yl]-4-butylbenzamide. Grade: 99%. CAS No. 1196723-95-1. Molecular formula: C26H23Cl2N3O. Mole weight: 464.39.
HSF1, GST tagged human
recombinant, expressed in E. coli, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy.
HSG-75, Electrically conductive heat sink grease, Ag ?75%
HSK0935 is a new class of Glucose Cotransporter 2 (SGLT2) inhibitor, which is for the treatment of Type 2 diabetes research. Synonyms: HSK-0935. CAS No. 1638851-44-1. Molecular formula: C22H25ClO7. Mole weight: 436.88.
HSK16149
HSK16149 is a voltage-gated calcium channel (VGCC) α2δ subunit selective ligand with analgesic activity in animal models of chronic pain. Synonyms: HSK 16149; HSK-16149; 2-((1S,2S,3R,6S,8S)-2-(aminomethyl)tricyclo[4.2.1.03,8]nonan-2-yl)acetic acid. Grade: ≥95%. CAS No. 2209104-84-5. Molecular formula: C12H19NO2. Mole weight: 209.28.
HSL-IN-1
HSL-IN-1 (compound 24b) is a potent and orally active hormone sensitive lipase (HSL) inhibitor (IC50=2 nM) with a significantly reduced reactive metabolite liability[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2095156-13-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101509.
HslU-HslV peptidase
The HslU subunit of the HslU-HslV complex functions as an ATP dependent 'unfoldase'. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolysed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. In peptidase family T1. Group: Enzymes. Synonyms: HslUV; HslV-HslU; HslV peptidase; ATP-dependent HslV-HslU proteinase; caseinolytic protease X; caseinolytic proteinase X; ClpXP ATP-dependent protease; ClpXP protease; ClpXP serine proteinase; Escherichia coli ClpXP serine proteinase; HslUV protease; HslUV proteinase; HslVU protease; HslVU proteinase; protease HslVU; proteinase HslUV. Enzyme Commission Number: EC 3.4.25.2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4375; HslU-HslV peptidase; EC 3.4.25.2; HslUV; HslV-HslU; HslV peptidase; ATP-dependent HslV-HslU proteinase; caseinolytic protease X; caseinolytic proteinase X; ClpXP ATP-dependent protease; ClpXP protease; ClpXP serine proteinase; Escherichia coli ClpXP serine proteinase; HslUV protease; HslUV proteinase; HslVU protease; HslVU proteinase; protease HslVU; proteinase HslUV. Cat No: EXWM-4375.
hSMG-1 inhibitor 11e
hSMG-1 inhibitor 11e is a potent, selective hSMG-1 kinase inhibitor with an IC50 of <0.05 nM. It shows>900-fold selectivity over mTOR (IC50 of 45 nM), PI3Kα/γ (IC50s of 61 nM and 92 nM) and CDK1/CDK2 (IC50s of 32 μM and 7.1 μM). Grade: 99%. CAS No. 1402452-10-1. Molecular formula: C26H27N7O3S. Mole weight: 517.61.
hSMG-1 inhibitor 11e
hSMG-1 inhibitor 11e is a potent and selective hSMG-1 kinase inhibitor with an IC50 of <0.05 nM. hSMG-1 inhibitor 11e shows>900-fold selectivity over mTOR (IC50 of 45 nM), PI3K?/? (IC50s of 61 nM and 92 nM) and CDK1/CDK2 (IC50s of 32 ?M and 7.1 ?M)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1402452-10-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124760.
hSMG-1 inhibitor 11j
hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1, with an IC50 of 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3K?/? (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 ?M). hSMG-1 inhibitor 11j can be used for the research of cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1402452-15-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124719.
Hsp110-STAT3 interaction-IN-1
Row174336 (compound 29) is a potent inhibitor of Hsp110-STAT3 interaction that shows antiproliferative activity against HPAEC cell line, with the IC 50 of 22.67 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 882582-26-5. Pack Sizes: 1 mg. Product ID: HY-Q43097.
Hsp25 Kinase Inhibitor
The Hsp25 Kinase Inhibitor controls the biological activity of Hsp25 KInase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
HSP27 inhibitor J2
HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: J2. CAS No. 2133499-85-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124653.
HSP27 inhibitor J2
HSP27 inhibitor J2 is an HSP27 inhibitor that can significantly induce abnormal formation of HSP27 dimer and inhibit the production of HSP27 giant polymers, thereby inhibiting the chaperone function of HSP27 and reducing its cellular protective function. It significantly enhances the anti-proliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition. Synonyms: J2; 4H-1-Benzopyran-4-one, 5-hydroxy-2-methyl-7-(2-thiiranylmethoxy)-; 5-Hydroxy-2-methyl-7-(thiiran-2-ylmethoxy)-4H-chromen-4-one; 5-Hydroxy-2-methyl-7-(2-thiiranylmethoxy)-4H-chromen-4-one. Grade: ≥95%. CAS No. 2133499-85-9. Molecular formula: C13H12O4S. Mole weight: 264.30.
Hsp40 active human
recombinant, expressed in E. coli, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy.
HSP40, GST tagged human
recombinant, expressed in E. coli, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy.
HSP47 inhibitor III
An inhibitor of the collagen-specific chaperone HSP47 with IC50 of 3.1 μM. HSP47 inhibitor III suppressed collagen type I expression in human and mouse cells and suppressed the viability and migration of lung fibroblasts. Synonyms: CBTC; Methyl 6-chloro-2-oxo-3H-1,2λ4,3-benzodithiazole-4-carboxylate. Grade: 98%. CAS No. 287917-38-8. Molecular formula: C8H6ClNO3S2. Mole weight: 263.72.
HSP70 Activator II, YM-08 ( (2Z, 5E) -3-ethyl-5- (3-methylbenzo[d]thiazol-2 (3H) -ylidene) -2- (pyridin-2-ylmethylene) thiazolidin-4-one, Heat Shock 70kD Protein Activator II, Hsp70 Chemical Co-Chaperone II, YM-08, YM08, YM8)
A cell-permeable, neutrally charged, pyridinium-to-pyridine substituted YM-01 and MKT-077 structural analog that exhibits higher HSP70-binding affinity, but reduced tau degradation-promoting potency in cultures (% degradation of p-tau/total tau = 42/64, 88/89, and 81/80 in HeLaC3 with 30uM YM-08, MKT-077, or YM-01, respectively) and weaker anti-cancer activity (IC50 against MDA-MB-231/MCF10A/MCF7 inuM = 1.4/3.0/2,2/MKT-077, 2.0/3.3/5.2/YM-01, and 8.5/7.8/10.5/YM-08 in 72h). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Hsp70-derived octapeptide
Hsp70-derived octapeptide is a C-terminal conserved octapeptide of HSP70 that interacts with the motif of tetratricopeptide repeat (TPR). Synonyms: H-Gly-Pro-Thr-Ile-Glu-Glu-Val-Asp-OH; glycyl-L-prolyl-L-threonyl-L-isoleucyl-L-alpha-glutamyl-L-alpha-glutamyl-L-valyl-L-aspartic acid. Grade: ≥95%. CAS No. 736171-62-3. Molecular formula: C36H58N8O16. Mole weight: 858.89.
HSP70, GST tagged human
recombinant, expressed in E. coli, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy.
HSP70-IN-1 is a heat shock protein (HSP) inhibitor that interferes with the formation of functional Hsp70-HOP-Hsp90 machinery, and it inhibits the growth of Kasumi-1 cells with an IC50 of 2.3 μM. Synonyms: HSP70-IN-1; HSP70 IN 1; 2-amino-N-[3-[2-(4-methylpiperazin-1-yl)-4-phenylmethoxypyrimidin-5-yl]sulfanylphenyl]acetamide; SCHEMBL1276103. CAS No. 1268273-90-0. Molecular formula: C24H28N6O2S. Mole weight: 464.58.
Hsp90a Active human
recombinant, expressed in E. coli, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy.
Hsp90b Active human
recombinant, expressed in E. coli, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy.
Hsp90-Cdc37-IN-1
Hsp90-Cdc37-IN-1, an Hsp90-Cdc37 interaction disruptor, can inhibit cell migration and reverse drug resistance, with an IC50 of 140 nM. Synonyms: Olean-12-en-29-oic acid, 3-[4-[(6-fluoro-2-benzothiazolyl)amino]-1,4-dioxobutoxy]-11-oxo-, ethyl ester, (3β,20β)-; Ethyl (3β)-3-({4-[(6-fluoro-1,3-benzothiazol-2-yl)amino]-4-oxobutanoyl}oxy)-11-oxoolean-12-en-30-oate. Grade: ≥95%. CAS No. 2227303-22-0. Molecular formula: C43H57FN2O6S. Mole weight: 748.99.
Hsp90-IN-17 (Example 5) hydrochloride is an HSP90 inhibitor that can be used in the study of proliferative diseases, such as cancer and neurodegenerative diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1253584-63-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148215A.
HSP90-IN-22
HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor with antiproliferative properties on cells with IC 50 values of 3.65 μM for MCF7 breast cancer cells and 2.71 μM for SKBr3 breast cancer cells, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 442898-75-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-153588.
HSP990
HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (HSP90) with potential antineoplastic activity. HSP990 binds to and inhibits the activity of Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation. HSP90, upregulated in a variety of tumor cells, is a molecular chaperone that plays a key role in the conformational maturation, stability and function of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation and/or immune responses. Synonyms: NVP-HSP990; NVP HSP990; NVPHSP990; HSP 990; HSP-990. Grade: >98%. CAS No. 934343-74-5. Molecular formula: C20H18FN5O2. Mole weight: 379.39.
HspA I
One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 20-fold overdigestion with enzyme more than 90% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 1000U; 5000U. G↑CGC CGC↓G. Activity: 20000u.a./ml. Appearance: 10 X SE-buffer Y. Storage: -20°C. Form: Liquid. Source: An E.coli strain that carries the cloned HspA I gene from Haemophilus species A1. Pack: 10 mM Tris-HCl (pH 7.5); 50 mM NaCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1124RE.
average Mn 1,500. Group: Poly(ethylene glycol) and poly(ethylene oxide).
HS-PEG1500-SH
Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. in addition to pegylation, activated peg derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity. Group: Poly(ethylene glycol) and poly(ethylene oxide). Alternative Names: HS-PEG-SH, Thiol-PEG-Thiol. Molecular formula: average Mn 1,500.
HS-PEG2K-NH2
HCl Salt, average Mn 2,000. Group: Poly(ethylene glycol) and poly(ethylene oxide).
HS-PEG2K-NH2
Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. in addition to pegylation, activated peg derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity. Group: Poly(ethylene glycol) and poly(ethylene oxide). Alternative Names: HS-PEG-NH2. Molecular formula: average Mn 2000.
HS-PEG3500-NH2
HCl Salt, average Mn 3,500. Group: Poly(ethylene glycol) and poly(ethylene oxide).
HS-PEG3500-NH2
Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. in addition to pegylation, activated peg derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity. Group: Poly(ethylene glycol) and poly(ethylene oxide). Alternative Names: HS-PEG-NH2. Molecular formula: average Mn 3500.
HS-PEG5K-NH2
HCl Salt, average Mn 5,000. Group: Poly(ethylene glycol) and poly(ethylene oxide).
HS-PEG5K-NH2
Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. in addition to pegylation, activated peg derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity. Group: Poly(ethylene glycol) and poly(ethylene oxide). Alternative Names: HS-PEG-NH2. Molecular formula: average Mn 5000.
HS-PEG7500-COOH
Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. in addition to pegylation, activated peg derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity. Group: Poly(ethylene glycol) and poly(ethylene oxide). Alternative Names: Thiol-PEG-Carboxyl, HS-PEG-COOH, HS-PEG-COOH. Molecular formula: average Mn 7,500.
HS-PEG7500-COOH
average Mn 7,500. Group: Poly(ethylene glycol) and poly(ethylene oxide).
HS-PEG7500-NH2
HCl Salt, average Mn 7,500. Group: Poly(ethylene glycol) and poly(ethylene oxide).
HS-PEG7500-NH2
Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. in addition to pegylation, activated peg derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity. Group: Poly(ethylene glycol) and poly(ethylene oxide). Alternative Names: HS-PEG-NH2. Molecular formula: average Mn 7,500.
HSPyU
HSPyU. Group: Biochemicals. Alternative Names: Dipyrrolidino (N-succinimidyloxy) carbenium hexafluorophosphate; N,N,N',N'-Bis(tetramethylene)-O-(N-succinimidyl)uronium hexafluorophosphate; O- (N-Succinimidyl) -N, N, N', N'-bis (tetramethylene) uronium hexafluorophosphate. Grades: Highly Purified. CAS No. 207683-26-9. Pack Sizes: 25g, 50g, 100g, 250g, 500g. Molecular Formula: C13H20F6N3O3P. US Biological Life Sciences.
Worldwide
HSR6071
HSR60716071, a novel pyrazinecarboxamide derivative, exhibits potent inhibition of the IgE-mediated passive cutaneous anaphylaxis (PCA) in rats on oral administration, and that its inhibition of PCA is at least in part due to the depression of allergic histamine release from mast cells. Synonyms: 6-pyrrolidin-1-yl-N-(2H-tetrazol-5-yl)pyrazine-2-carboxamide; 6-(1-pyrrolidinyl)-N-(1H-tetrazol-5-yl)-2-pyrazinecarboxamide; HSR 6071l; HSR-6071. CAS No. 111374-21-1. Molecular formula: C10H12N8O. Mole weight: 260.26.
HSTU
HSTU. Group: Biochemicals. Alternative Names: N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate; O-(N-Succinimidyl)-N,N,N',N'-tetramethyluronium hexafluorophosphate. Grades: Highly Purified. CAS No. 265651-18-1. Pack Sizes: 50g, 100g, 250g, 500g, 1kg. Molecular Formula: C9H16F6N3O3P. US Biological Life Sciences.
Worldwide
HSV-1-amide UL 26 Open Reading Frame (242-255)
HSV-1-amide UL 26 Open Reading Frame (242-255) is a highly characteristic substrate of the herpes simplex virus type 1 protease (HSV-1), which is essential for viral nucleocapsid formation and viral replication. The C-terminal cleavage product of HTYLQASEKFKMWG-amide is detected by fluorescence detector at 280 nm (excitation) and 350 nm (emission), respectively. Synonyms: H-His-Thr-Tyr-Leu-Gln-Ala-Ser-Glu-Lys-Phe-Lys-Met-Trp-Gly-NH2; L-histidyl-L-threonyl-L-tyrosyl-L-leucyl-L-glutaminyl-L-alanyl-L-seryl-L-alpha-glutamyl-L-lysyl-L-phenylalanyl-L-lysyl-L-methionyl-L-tryptophyl-glycinamide; Glycinamide, L-histidyl-L-threonyl-L-tyrosyl-L-leucyl-L-glutaminyl-L-alanyl-L-seryl-L-α-glutamyl-L-lysyl-L-phenylalanyl-L-lysyl-L-methionyl-L-tryptophyl-. Grade: ≥95%. CAS No. 396716-24-8. Molecular formula: C80H117N21O20S. Mole weight: 1724.98.
HSV-gB2 (498-505)
HSV-gB2 (498-505) is an immunodominant epitope from herpes simplex virus (HSV) glycoprotein B residues 498-505, acts as H-2Kb-restricted and HSV-1/2-cross-reactive cytotoxic T-lymphocyte (CTL) recognition epitope [1]. Uses: Scientific research. Group: Peptides. CAS No. 149997-91-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1862.
HSV-gB2 498-505
HSV-gB2 498-505 is an immunodominant epitope derived from the herpes simplex virus (HSV) glycoprotein B residues 498-505, and is a cytotoxic T lymphocyte (CTL) recognition epitope with H-2kB restriction and HSV-1/2 cross-reaction. Synonyms: H-Ser-Ser-Ile-Glu-Phe-Ala-Arg-Leu-OH; L-seryl-L-seryl-L-isoleucyl-L-alpha-glutamyl-L-phenylalanyl-L-alanyl-L-arginyl-L-leucine. Grade: ≥95%. CAS No. 149997-91-1. Molecular formula: C41H67N11O13. Mole weight: 922.04.
HT-2157 (SNAP 37889) is a selective, high-affinity, competitive antagonists of galanin-3 receptor (Gal3). Uses: Scientific research. Group: Signaling pathways. Alternative Names: SNAP 37889. CAS No. 303149-14-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100717.
HT-2 toxin
HT-2 toxin is a mycotoxin produced by Fusarium sp. Symptoms of poisoning are nausea, vomiting, diarrhea, and leukopenia. The acute toxicity is lower than trichothecene. Uses: This product is used as a reference standard in quantitative analysis of food stuffs. Synonyms: Mycotoxin HT 2; Toxin HT 2. CAS No. 26934-87-2. Molecular formula: C22H32O8. Mole weight: 424.48.
HT-2 Toxin
HT-2 Toxin is a trichothecene group mycotoxin. HT-2 Toxin is the 4-hydroxy analogue of T-2 Toxin which has been shown to induce DNA damage and cell death on prolonged administration. Group: Biochemicals. Alternative Names: (3α,4 β,8α)-12,13-Epoxytrichothec-9-ene-3,4,8,15-tetrol 8-(3-Methylbutanoate) 15-Acetate; 12,13-Epoxytrichothec-9-ene-3α,4 β,8α,15-tetro 15-Acetate 8-Isovalerate; 3,4-Dihydroxy-15-acetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-Δ9-trichothecene; Isovaleric Acid 8-Ester with 12,13-epoxytrichothec-9-ene-3α,4 β,8α,15-tetrol 15-Acetate; HT 2; HT 2 Toxin; Mycotoxin HT 2; NSC 278571; Toxin HT 2. Grades: Highly Purified. CAS No. 26934-87-2. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
HT-61
HT-61, also known as HY-50A, is a pyrroloquinolone antibiotic potentially for the treatment of staphylococcal infections. HT61 was effective at reducing biofilm viability and was associated with increased expression of cell wall stress and division proteins, confirming its potential as a treatment for S. aureus biofilm infections. HT61 enhances the effect of tobramycin against Pseudomonas aeruginosa in vitro and in vivo. Uses: Designed for use in research and industrial production. Additional or Alternative Names: HT-61; HT61; HT 61; HY-50A; HY 50A; HY50A. Product Category: Others. Appearance: Solid powder. CAS No. 936622-80-9. Molecular formula: C26H24N2O. Mole weight: 380.49. Purity: >98%. IUPACName: 4-methyl-1-phenethyl-8-phenoxy-2,3-dihydro-1H-pyrrolo[3,2-c]quinoline. Canonical SMILES: CC1=NC2=CC=C(OC3=CC=CC=C3)C=C2C4=C1CCN4CCC5=CC=CC=C5. Product ID: ACM936622809. Alfa Chemistry ISO 9001:2015 Certified. Categories: HQ-6.
HTBA
HTBA(3-Hydroxy-2,4,6-triiodobenzoic acid) for your research needs. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 53279-72-4. Pack Sizes: 10 mM * 1 mL; 5 g. Product ID: HY-15919.
HTH-01-015 is a selective NUAK1/ARK5 inhibitor (IC50 is 100 nM). HTH-01-015 inhibits NUAK1 with >100-fold higher potency than NUAK2 (IC50 of >10 ?M). Uses: Scientific research. Group: Signaling pathways. CAS No. 1613724-42-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12334.
HTH-01-015
HTH-01-015 is a potent and selective inhibitor of NUAK1 (IC50 = 100 nM) and does not affect the activity of a panel of 139 other kinases, including additional AMPK family members. The administration of HTH-01-015 to MEFs (mouse embryonic fibroblasts) significantly inhibits migration in a wound-healing assay to a similar extent as NUAK1-knockout. HTH-01-015 also inhibit proliferation of MEFs to the same extent as NUAK1 knockout and U2OS cells to the same extent as NUAK1 shRNA knockdown. HTH-01-015 impaired the invasive potential of U2OS cells in a 3D cell invasion assay to the same extent as NUAK1 knockdown. HTH-01-015 will serve as useful chemical probes to delineate the biological roles of the NUAK kinases. Uses: Designed for use in research and industrial production. Additional or Alternative Names: HTH-01-015; HTH01-015; HTH 01-015; HTH-01015; HTH01015; HTH 01015. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1613724-42-7. Molecular formula: C26H28N8O. Mole weight: 468.57. Purity: >98%. IUPACName: 4,5,13-trimethyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5,13-dihydro-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one. Canonical SMILES: CC1=C(N(C)C(C2=CC(C=CC=C3)=C3C=C2N4C)=O)C4=NC(NC5=CN(N=C5)C6CCNCC6)=N1. Product ID: ACM1613724427. Alfa Chemistry ISO 9001:2015 Certified.
HTH-01-015
HTH-01-015 is a potent and selective inhibitor of NUAK1 with IC50 of 100 nM, does not significantly inhibit NUAK2 (IC50 of >10 μM). Synonyms: HTH-01-015; HTH01-015; HTH 01-015; HTH-01015; HTH01015; HTH 01015. Grade: >98%. CAS No. 1613724-42-7. Molecular formula: C26H28N8O. Mole weight: 468.55.
H-Thr(ac)-oh
H-Thr(ac)-oh. Uses: Designed for use in research and industrial production. Additional or Alternative Names: O-ACETYL-L-THREONINE;H-THR(AC)-OH. CAS No. 17012-42-9. Molecular formula: C6H11NO4. Mole weight: 161.16. Purity: 0.98. IUPACName: (2S,3R)-3-acetyloxy-2-aminobutanoicacid. Canonical SMILES: CC(C(C(=O)O)N)OC(=O)C. Product ID: ACM17012429. Alfa Chemistry ISO 9001:2015 Certified.