A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway. Uses: Scientific research. Group: Signaling pathways. Alternative Names: endo-IWR 1; IWR-1-endo. CAS No. 1127442-82-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12238.
IWR-1-endo
IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM. Synonyms: IWR-1; IWR 1; IWR1; IWR-1-endo. Grades: >98%. CAS No. 1127442-82-3. Molecular formula: C25H19N3O3. Mole weight: 409.44.
IWR-1 (IWR-1-endo)
Potent and reversible cell permeable Wnt pathway signaling inhibitor. Inhibits Wnt-induced accumulation of β-catenin, leading to proteasomal degradation of this protein through a destruction complex which consists of Apc, Axin2, CK1 and GSK-3 β. Stabilizes the destruction complex, increasing the level of Axin2 protein without changing the levels of Apc or GSK-3 β. Tankyrase-1 (TNKS1/PARP5a) and Tankyrase-2 (TNKS2/PARP5b) inhibitor (in vitro auto-PARsylation assay). Group: Biochemicals. Alternative Names: 4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide. Grades: Highly Purified. CAS No. 1127442-82-3. Pack Sizes: 5mg, 25mg. Molecular Formula: C??H??N?O?, Molecular Weight: 409.4. US Biological Life Sciences.
Worldwide
IXA4
IXA4 is a highly selective, non-toxic IRE1/XBP1s activator. IXA4 transiently activates protective IRE1/XBP1s signaling in liver without inducing RIDD or TRAF2/JNK signaling. IXA4 treatment improves systemic glucose metabolism and liver insulin action through IRE1-dependent remodeling of the hepatic transcriptome that reduces glucose production and steatosis. IXA4-stimulated IRE1 activation also enhances pancreatic function. Our findings indicate that systemic, transient activation of IRE1/XBP1s signaling engenders multi-tissue benefits that integrate to mitigate obesity-driven metabolic dysfunction. Uses: Designed for use in research and industrial production. Additional or Alternative Names: IXA4; IXA-4; IXA 4. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1185329-96-7. Molecular formula: C24H28N4O4. Mole weight: 436.51. Purity: >98%. IUPACName: N-(1-(2-(methyl(2-(p-tolyloxy)ethyl)amino)-2-oxoethyl)-1H-pyrazol-4-yl)-3-phenoxypropanamide. Canonical SMILES: CC1=CC=C(OCCN(C(CN2N=CC(NC(=O)CCOC3=CC=CC=C3)=C2)=O)C)C=C1. Product ID: ACM1185329967. Alfa Chemistry ISO 9001:2015 Certified. Categories: Ixazomib.
Ixabepilone
Ixabepilone (BMS-247550) is an orally bioavailable microtubule inhibitor, which binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arrests cells in the G2-M phase of the cell cycle and induces tumor cell apoptosis. Uses: Designed for use in research and industrial production. Additional or Alternative Names: IXABEPILONE;(1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-1,5,7,9,9-pentamethyl-14-[(E) -1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-13-azabicyclo[14. 1.0]heptadecane-8,12-dione;Aza-epothilone B;Bms 247550-1;Ixempra;Ixempra kit;Unii-K27005np0a;Azi-epothilone B. Product Category: Inhibitors. Appearance: Solid. CAS No. 219989-84-1. Molecular formula: C27H42N2O5S. Mole weight: 506.7. Purity: 0.9984. Canonical SMILES: O=C([C@@H]([C@H]([C@H](CCC[C@]1(O[C@]1(C[C@H](N2)/C(C)=C/C3=CSC(C)=N3)[H])C)C)O)C)C(C)([C@H](CC2=O)O)C. Product ID: ACM219989841. Alfa Chemistry ISO 9001:2015 Certified.
Ixabepilone
Ixabepilone (BMS-247550) is an orally bioavailable microtubule inhibitor, which binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arrests cells in the G2-M phase of the cell cycle and induces tumor cell apoptosis. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-247550; Aza-epothilone B. CAS No. 219989-84-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-10222.
Ixabepilone
Ixabepilone (also known as azaepothilone B, or BMS-247550) is an orally bioavailable microtubule inhibitor. Ixabepilone was a semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane-resistant cell lines. Ixabepilone was approved in 2007. Synonyms: Azaepothilone B; BMS247550; BMS-247550; BMS 247550; Ixempra. Grades: >98%. CAS No. 219989-84-1. Molecular formula: C27H42N2O5S. Mole weight: 506.7.
Ixabepilone
16-Aza-epothilone B. CAS No. 219989-84-1. Product ID: 8-04669. Molecular formula: C27H42N2O5S. Mole weight: 506.7.
an impurity of ixabepilone. Synonyms: (4S,7R,8S,9S,13R,14R)-14-((S,E)-2-Amino-3-methyl-4-(2-methylthiazol-4-yl)but-3-en-1-yl)-4,8,13-trihydroxy-5,5,7,9,13-pentamethyloxacyclotetradecane-2,6-dione. Grades: > 95%. CAS No. 1220999-09-6. Molecular formula: C27H44N2O6S. Mole weight: 524.73.
Ixabepilone Impurity 7
an impurity of ixabepilone. Synonyms: (3S,6R,7S,8S)-11-((2R,3S)-3-((S,E)-2-Azido-3-methyl-4-(2-methylthiazol-4-yl)but-3-en-1-yl)-2-methyloxiran-2-yl)-3,7-dihydroxy-4,4,6,8-tetramethyl-5-oxoundecanoic Acid. Grades: > 95%. Molecular formula: C27H42N4O6S. Mole weight: 550.72.
Ixaconazole chloride
Ixaconazole chloride. Uses: For analytical and research use. Group: Impurity standards. CAS No. 497235-79-7. Molecular Formula: C35H36Cl2F2N8O5S. Mole Weight: 789.68. Catalog: APB497235797.
Ixaconazole Impurity31
Ixaconazole Impurity31. Uses: For analytical and research use. Group: Impurity standards. CAS No. 40805-50-3. Molecular Formula: C9H6ClNO. Mole Weight: 179.6. Catalog: APB40805503.
Ixaconazole-Intermediate 11 (p-cyanoacetophenone)
Ixaconazole-Intermediate 11 (p-cyanoacetophenone). Uses: For analytical and research use. Group: Impurity standards. CAS No. 1443-80-7. Molecular Formula: C9H7NO. Mole Weight: 145.16. Catalog: APB1443807.
Ixaconazole side chain intermediate 3
Ixaconazole side chain intermediate 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 20099-89-2. Molecular Formula: C9H6BrNO. Mole Weight: 224.05. Catalog: APB20099892.
Ixaconazole side chain intermediate 4
Ixaconazole side chain intermediate 4. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C14H19CIN2O4. Mole Weight: 314.77. Catalog: APB10584.
Ixazomib
Ixazomib (MLN2238) is a selective, potent, and reversible proteasome inhibitor, which inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC 50 of 3.4 nM ( K i of 0.93 nM). Uses: Scientific research. Group: Signaling pathways. Alternative Names: MLN2238. CAS No. 1072833-77-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10453.
Ixazomib
Ixazomib is a proteasome inhibitor and the biologically active form of MLN9708. Ixazomib exhibits an improved pharmacodynamic profile and antitumor activity compared with bortezomib in both OCI-Ly10 and PHTX22L models. Although both Ixazomib and bortezomib prolonged overall survival, reduced splenomegaly, and attenuated IgG2a levels in the iMyc(Cα)/Bcl-X(L) GEM model, only Ixazomib alleviated osteolytic bone disease in the DP54-Luc model. Synonyms: MLN2238; MLN-2238; MLN 2238; Ixazomib. Trade name: Ninlaro. (R)-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)boronic acid. Grades: > 95%. CAS No. 1072833-77-2. Molecular formula: C14H19BCl2N2O4. Mole weight: 361.026.
Ixazomib citrate
Ixazomib citrate (MLN9708) is a selective, orally active, second-generation proteasome inhibitor. Ixazomib citrate can be used for the study of a broad range of human malignancies [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MLN9708. CAS No. 1239908-20-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10452.
Ixazomib Impurity 1
Ixazomib Impurity 1. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-2,2'-(2-(1-(2,5-dichlorobenzamido)-3-methylbutyl)-5-oxo-1,3,2-dioxaborolane-4,4-diyl)diacetic acid. Molecular Formula: C18H20BCl2NO8. Mole Weight: 460.07. Catalog: APB02180.
Ixazomib Impurity 20. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1429055-05-9. Molecular Formula: C14H16Cl2N2O2. Mole Weight: 315.19. Catalog: APB1429055059.
Ixazomib Impurity 21
Ixazomib Impurity 21. Uses: For analytical and research use. Group: Impurity standards. CAS No. 54730-36-8. Molecular Formula: C7H3Cl5. Mole Weight: 264.35. Catalog: APB54730368.
Ixazomib Impurity 22
Ixazomib Impurity 22. Uses: For analytical and research use. Group: Impurity standards. CAS No. 10541-71-6. Molecular Formula: C7H3Cl5. Mole Weight: 264.35. Catalog: APB10541716.
Ixazomib Impurity 23
Ixazomib Impurity 23. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C14H16Cl2N2O2. Mole Weight: 315.19. Catalog: APB10563.
Ixazomib Impurity 24
Ixazomib Impurity 24. Uses: For analytical and research use. Group: Impurity standards. CAS No. 50-82-8. Molecular Formula: C7H3Cl3O2. Mole Weight: 225.45. Catalog: APB50828.
Ixazomib Impurity 25
Ixazomib Impurity 25. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C14H8Cl4N2O4S. Mole Weight: 442.09. Catalog: APB10564.
Ixazomib Impurity 26
Ixazomib Impurity 26. Uses: For analytical and research use. Group: Impurity standards. CAS No. 6660-65-7. Molecular Formula: C8H4Cl2O4. Mole Weight: 235.02. Catalog: APB6660657.
Ixazomib Impurity 27
Ixazomib Impurity 27. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R) - (3-methyl-1- (2- (2, 3, 5-trichlorobenzamido) acetamido) butyl) boronic acid. Molecular Formula: C14H18BCl3N2O4. Mole Weight: 395.47. Catalog: APB02173.
Ixazomib Impurity 28
Ixazomib Impurity 28. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C20H23BCl2N2O9. Mole Weight: 517.12. Catalog: APB10565.
Ixazomib Impurity 29
Ixazomib Impurity 29. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-(2,3,5-trichlorobenzamido)acetic acid. Molecular Formula: C9H6Cl3NO3. Mole Weight: 282.51. Catalog: APB02172.
Ixazomib Impurity 3
Ixazomib Impurity 3. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-(2-(2,5-dichlorobenzamido)acetamido)acetic acid. Molecular Formula: C11H10Cl2N2O4. Mole Weight: 305.11. Catalog: APB02178.
Ixazomib Impurity 30
Ixazomib Impurity 30. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-2,2'-(2-(3-methyl-1-(2,3,5-trichlorobenzamido)butyl)-5-oxo-1,3,2-dioxaborolane-4,4-diyl)diacetic acid. Molecular Formula: C18H19BCl3NO8. Mole Weight: 494.52. Catalog: APB02171.
Ixazomib Impurity 31
Ixazomib Impurity 31. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R) - (3-methyl-1- (2- (2, 4, 5-trichlorobenzamido) acetamido) butyl) boronic acid. Molecular Formula: C14H18BCl3N2O4. Mole Weight: 395.47. Catalog: APB02169.
Ixazomib Impurity 32
Ixazomib Impurity 32. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-2,2'-(2-(3-methyl-1-(2-(2,4,5-trichlorobenzamido)acetamido)butyl)-5-oxo-1,3,2-dioxaborolane-4,4-diyl)diacetic acid. Molecular Formula: C20H22BCl3N2O9. Mole Weight: 551.57. Catalog: APB02170.
Ixazomib Impurity 33
Ixazomib Impurity 33. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-(2,4,5-trichlorobenzamido)acetic acid. Molecular Formula: C9H6Cl3NO3. Mole Weight: 282.51. Catalog: APB02166.
Ixazomib Impurity 34
Ixazomib Impurity 34. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-2,2'-(2-(3-methyl-1-(2,4,5-trichlorobenzamido)butyl)-5-oxo-1,3,2-dioxaborolane-4,4-diyl)diacetic acid. Molecular Formula: C18H19BCl3NO8. Mole Weight: 494.52. Catalog: APB02168.
Ixazomib Impurity 39
Ixazomib Impurity 39. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2,5-dichloro-N-(2-(isopentylamino)-2-oxoethyl)benzamide. Molecular Formula: C14H18Cl2N2O2. Mole Weight: 317.21. Catalog: APB02167.
Ixazomib Impurity 4
Ixazomib Impurity 4. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-2,5-dichloro-N-(2-((1-hydroxy-3-methylbutyl)amino)-2-oxoethyl)benzamide. Molecular Formula: C14H18Cl2N2O3. Mole Weight: 333.21. Catalog: APB02177.
Ixazomib Impurity 44
Ixazomib Impurity 44. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2,4,5-trichloro-N-(2-(((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-2-oxoethyl)benzamide. Molecular Formula: C24H32BCl3N2O4. Mole Weight: 528.15. Catalog: APB01507.
Ixazomib Impurity 5
Ixazomib Impurity 5. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-2,5-dichloro-N-(2-((1-hydroxy-3-methylbutyl)amino)-2-oxoethyl)benzamide. Molecular Formula: C14H18Cl2N2O3. Mole Weight: 333.21. Catalog: APB02179.
Ixazomib Impurity 6
Ixazomib Impurity 6. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-2,5-dichloro-N-(2-((1-hydroperoxy-3-methylbutyl)amino)-2-oxoethyl)benzamide. Molecular Formula: C14H18Cl2N2O4. Mole Weight: 349.21. Catalog: APB02176.
Ixazomib Impurity 64
Ixazomib Impurity 64. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)boronic acid. Molecular Formula: C14H19BCl2N2O4. Mole Weight: 360.08. Catalog: APB02165.
Ixazomib Impurity 65
Ixazomib Impurity 65. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-2,2'-(2-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-5-oxo-1,3,2-dioxaborolane-4,4-diyl)diacetic acid. Molecular Formula: C20H23BCl2N2O9. Mole Weight: 517.12. Catalog: APB02164.
Ixazomib Impurity 66
Ixazomib Impurity 66. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-(1-(2,5-dichlorobenzamido)-3-methylbutyl)boronic acid. CAS No. 2806031-79-6. Molecular Formula: C12H16BCl2NO3. Mole Weight: 303.06. Catalog: APB2806031796.
Ixazomib Impurity 67
Ixazomib Impurity 67. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-(2,5-dichlorobenzamido)acetic acid. CAS No. 667403-46-5. Molecular Formula: C9H7Cl2NO3. Mole Weight: 246.98. Catalog: APB667403465.
Ixazomib Impurity 68
Ixazomib Impurity 68. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R) - (1- (2- (2- (2, 5-dichlorobenzamido) acetamido) acetamido) -3-methylbutyl) boronic acid. Molecular Formula: C16H22BCl2N3O5. Mole Weight: 417.10. Catalog: APB02163.
Ixazomib Impurity 69
Ixazomib Impurity 69. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R) -2, 2'- (2- (1- (2- (2- (2, 5-dichlorobenzamido) acetamido) acetamido) -3-methylbutyl) -5-oxo-1, 3, 2-dioxaborolane-4, 4-diyl) diacetic acid. Molecular Formula: C22H26BCl2N3O10. Mole Weight: 573.11. Catalog: APB02162.
Ixazomib Impurity 70
Ixazomib Impurity 70. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-2,2'-(2-(3-methyl-1-(2-(2,3,5-trichlorobenzamido)acetamido)butyl)-5-oxo-1,3,2-dioxaborolane-4,4-diyl)diacetic acid. Molecular Formula: C20H22BCl3N2O9. Mole Weight: 550.05. Catalog: APB02161.
Ixazomib Impurity 9
Ixazomib Impurity 9. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1092351-67-1. Molecular Formula: C16H16N6O. Mole Weight: 308.35. Catalog: APB1092351671.
ixekizumab
Ixekizumab is a humanized monoclonal antibody that inhibits interleukin 17A (IL-17A). It was approved by FDA for the treatment of moderate to severe plaque psoriasis in adult patients. Uses: The treatment of plaque psoriasis. Synonyms: LY2439821; Taltz. Grades: ≥98%. CAS No. 1143503-69-8. Molecular formula: C6492H10012N1728O2028S46. Mole weight: 146200.
Ixekizumab
Ixekizumab (LY2439821) is a humanized IgG4 monoclonal antibody that selectively binds and neutralizes interleukin IL-17A ( K D <3 pM). Ixekizumab directly blocks IL-17A binding to IL-17RA (IL-17A receptor) but does not bind to other IL-17 family members. Ixekizumab is used for the research of moderate-to-severe plaque psoriasis [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: LY2439821. CAS No. 1143503-69-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P9924.
Ixoroside
Ixoroside is an intriguing biomedical compound used for studying malignant tumors, spanning from the intricate lung to the formidable breast and pancreatic neoplasms. Synonyms: (1S,4aS,7S,7aS)-1-(b-D-Glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-7-hydroxy-7-methylcyclopenta[c]pyran-4-carboxaldehyde. CAS No. 58514-30-0. Molecular formula: C16H24O9. Mole weight: 360.36.