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| Product | Description | |
|---|---|---|
| IWR-1 | IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway. Uses: Scientific research. Group: Signaling pathways. Alternative Names: endo-IWR 1; IWR-1-endo. CAS No. 1127442-82-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12238. |  |
| IWR-1 | IWR-1. CAS No: 430429-02-0 |  Sarchem Laboratories New Jersey NJ |
| IWR-1-endo | IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM. Synonyms: IWR-1; IWR 1; IWR1; IWR-1-endo. Grades: >98%. CAS No. 1127442-82-3. Molecular formula: C25H19N3O3. Mole weight: 409.44. |  |
| IWR-1 (IWR-1-endo) | Potent and reversible cell permeable Wnt pathway signaling inhibitor. Inhibits Wnt-induced accumulation of β-catenin, leading to proteasomal degradation of this protein through a destruction complex which consists of Apc, Axin2, CK1 and GSK-3 β. Stabilizes the destruction complex, increasing the level of Axin2 protein without changing the levels of Apc or GSK-3 β. Tankyrase-1 (TNKS1/PARP5a) and Tankyrase-2 (TNKS2/PARP5b) inhibitor (in vitro auto-PARsylation assay). Group: Biochemicals. Alternative Names: 4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide. Grades: Highly Purified. CAS No. 1127442-82-3. Pack Sizes: 5mg, 25mg. Molecular Formula: C??H??N?O?, Molecular Weight: 409.4. US Biological Life Sciences. |  Worldwide |
| IXA4 | IXA4 is a highly selective, non-toxic IRE1/XBP1s activator. IXA4 transiently activates protective IRE1/XBP1s signaling in liver without inducing RIDD or TRAF2/JNK signaling. IXA4 treatment improves systemic glucose metabolism and liver insulin action through IRE1-dependent remodeling of the hepatic transcriptome that reduces glucose production and steatosis. IXA4-stimulated IRE1 activation also enhances pancreatic function. Our findings indicate that systemic, transient activation of IRE1/XBP1s signaling engenders multi-tissue benefits that integrate to mitigate obesity-driven metabolic dysfunction. Uses: Designed for use in research and industrial production. Additional or Alternative Names: IXA4; IXA-4; IXA 4. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1185329-96-7. Molecular formula: C24H28N4O4. Mole weight: 436.51. Purity: >98%. IUPACName: N-(1-(2-(methyl(2-(p-tolyloxy)ethyl)amino)-2-oxoethyl)-1H-pyrazol-4-yl)-3-phenoxypropanamide. Canonical SMILES: CC1=CC=C(OCCN(C(CN2N=CC(NC(=O)CCOC3=CC=CC=C3)=C2)=O)C)C=C1. Product ID: ACM1185329967. Alfa Chemistry ISO 9001:2015 Certified. Categories: Ixazomib. |  |
| Ixabepilone | 16-Aza-epothilone B. CAS No. 219989-84-1. Product ID: 8-04669. Molecular formula: C27H42N2O5S. Mole weight: 506.7. |  |
| Ixabepilone | Ixabepilone (BMS-247550) is an orally bioavailable microtubule inhibitor, which binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arrests cells in the G2-M phase of the cell cycle and induces tumor cell apoptosis. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-247550; Aza-epothilone B. CAS No. 219989-84-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-10222. | |
| Ixabepilone | Ixabepilone (BMS-247550) is an orally bioavailable microtubule inhibitor, which binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arrests cells in the G2-M phase of the cell cycle and induces tumor cell apoptosis. Uses: Designed for use in research and industrial production. Additional or Alternative Names: IXABEPILONE;(1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-1,5,7,9,9-pentamethyl-14-[(E) -1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-13-azabicyclo[14. 1.0]heptadecane-8,12-dione;Aza-epothilone B;Bms 247550-1;Ixempra;Ixempra kit;Unii-K27005np0a;Azi-epothilone B. Product Category: Inhibitors. Appearance: Solid. CAS No. 219989-84-1. Molecular formula: C27H42N2O5S. Mole weight: 506.7. Purity: 0.9984. Canonical SMILES: O=C([C@@H]([C@H]([C@H](CCC[C@]1(O[C@]1(C[C@H](N2)/C(C)=C/C3=CSC(C)=N3)[H])C)C)O)C)C(C)([C@H](CC2=O)O)C. Product ID: ACM219989841. Alfa Chemistry ISO 9001:2015 Certified. | |
| Ixabepilone | Ixabepilone (also known as azaepothilone B, or BMS-247550) is an orally bioavailable microtubule inhibitor. Ixabepilone was a semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane-resistant cell lines. Ixabepilone was approved in 2007. Synonyms: Azaepothilone B; BMS247550; BMS-247550; BMS 247550; Ixempra. Grades: >98%. CAS No. 219989-84-1. Molecular formula: C27H42N2O5S. Mole weight: 506.7. | |
| Ixabepilone Impurity 1 | Grades: > 95%. Molecular formula: C27H42N2O5S. Mole weight: 506.71. | |
| Ixabepilone Impurity 2 | an impurity of Ixabepilone. Synonyms: (Z)-Ixabepilone; (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-((Z)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione. Grades: > 95%. CAS No. 1220999-07-4. Molecular formula: C27H42N2O5S. Mole weight: 506.71. | |
| Ixabepilone Impurity 3 | Grades: > 95%. Molecular formula: C27H42N2O5S. Mole weight: 506.71. | |
| Ixabepilone Impurity 4 | Grades: > 95%. Molecular formula: C27H44N2O6S. Mole weight: 524.73. | |
| Ixabepilone Impurity 6 | an impurity of ixabepilone. Synonyms: (4S,7R,8S,9S,13R,14R)-14-((S,E)-2-Amino-3-methyl-4-(2-methylthiazol-4-yl)but-3-en-1-yl)-4,8,13-trihydroxy-5,5,7,9,13-pentamethyloxacyclotetradecane-2,6-dione. Grades: > 95%. CAS No. 1220999-09-6. Molecular formula: C27H44N2O6S. Mole weight: 524.73. | |
| Ixabepilone Impurity 7 | an impurity of ixabepilone. Synonyms: (3S,6R,7S,8S)-11-((2R,3S)-3-((S,E)-2-Azido-3-methyl-4-(2-methylthiazol-4-yl)but-3-en-1-yl)-2-methyloxiran-2-yl)-3,7-dihydroxy-4,4,6,8-tetramethyl-5-oxoundecanoic Acid. Grades: > 95%. Molecular formula: C27H42N4O6S. Mole weight: 550.72. | |
| Ixazomib | Ixazomib is a proteasome inhibitor and the biologically active form of MLN9708. Ixazomib exhibits an improved pharmacodynamic profile and antitumor activity compared with bortezomib in both OCI-Ly10 and PHTX22L models. Although both Ixazomib and bortezomib prolonged overall survival, reduced splenomegaly, and attenuated IgG2a levels in the iMyc(Cα)/Bcl-X(L) GEM model, only Ixazomib alleviated osteolytic bone disease in the DP54-Luc model. Synonyms: MLN2238; MLN-2238; MLN 2238; Ixazomib. Trade name: Ninlaro. (R)-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)boronic acid. Grades: > 95%. CAS No. 1072833-77-2. Molecular formula: C14H19BCl2N2O4. Mole weight: 361.026. | |
| Ixazomib | Ixazomib (MLN2238) is a selective, potent, and reversible proteasome inhibitor, which inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC 50 of 3.4 nM ( K i of 0.93 nM). Uses: Scientific research. Group: Signaling pathways. Alternative Names: MLN2238. CAS No. 1072833-77-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10453. | |
| Ixazomib citrate | Ixazomib citrate (MLN9708) is a selective, orally active, second-generation proteasome inhibitor. Ixazomib citrate can be used for the study of a broad range of human malignancies [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MLN9708. CAS No. 1239908-20-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10452. | |
| Ixazomib Impurity 1 | Grades: > 95%. CAS No. 1201903-02-7. Molecular formula: C24H33BCl2N2O4. Mole weight: 495.26. | |
| Ixazomib Impurity 15 | Ixazomib Impurity 15. Uses: For analytical and research use. Group: Impurity standards. CAS No. 10203-08-4. Molecular formula: C7H4Cl2O. Mole weight: 175.01. Catalog: APB10203084. |  |
| Ixazomib Impurity 19 | Ixazomib Impurity 19. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1239908-20-3. Molecular formula: C20H23BCl2N2O9. Mole weight: 517.12. Catalog: APB1239908203. | |
| Ixazomib Impurity 2 | Grades: > 95%. Molecular formula: C24H33BCl2N2O4. Mole weight: 495.26. | |
| Ixazomib Impurity 22 | Ixazomib Impurity 22. Uses: For analytical and research use. Group: Impurity standards. CAS No. 10541-71-6. Molecular formula: C7H3Cl5. Mole weight: 264.35. Catalog: APB10541716. | |
| Ixazomib Impurity 9 | Ixazomib Impurity 9. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1092351-67-1. Molecular formula: C16H16N6O. Mole weight: 308.35. Catalog: APB1092351671. | |
| ixekizumab | Ixekizumab is a humanized monoclonal antibody that inhibits interleukin 17A (IL-17A). It was approved by FDA for the treatment of moderate to severe plaque psoriasis in adult patients. Uses: The treatment of plaque psoriasis. Synonyms: LY2439821; Taltz. Grades: ≥98%. CAS No. 1143503-69-8. Molecular formula: C6492H10012N1728O2028S46. Mole weight: 146200. | |
| Ixekizumab | Ixekizumab (LY2439821) is a humanized IgG4 monoclonal antibody that selectively binds and neutralizes interleukin IL-17A ( K D <3 pM). Ixekizumab directly blocks IL-17A binding to IL-17RA (IL-17A receptor) but does not bind to other IL-17 family members. Ixekizumab is used for the research of moderate-to-severe plaque psoriasis [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: LY2439821. CAS No. 1143503-69-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P9924. | |
| Ixoroside | Ixoroside is an intriguing biomedical compound used for studying malignant tumors, spanning from the intricate lung to the formidable breast and pancreatic neoplasms. Synonyms: (1S,4aS,7S,7aS)-1-(b-D-Glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-7-hydroxy-7-methylcyclopenta[c]pyran-4-carboxaldehyde. CAS No. 58514-30-0. Molecular formula: C16H24O9. Mole weight: 360.36. | |
| Ixosin | Ixosin is an antibacterial peptide isolated from Ixodes sinensis (Hard tick). It has activity against gram-negative bacteria and fungi. Synonyms: Gly-Leu-His-Lys-Val-Met-Arg-Glu-Val-Leu-Gly-Tyr-Glu-Arg-Asn-Ser-Tyr-Lys-Lys-Phe-Phe-Leu-Arg. Grades: 96.7%. Molecular formula: C132H208N38O32S. Mole weight: 2871.4. | |
| Ixosin-B | Ixosin-B is an antibacterial peptide isolated from Ixodes sinensis (Hard tick). It has activity against gram-positive bacteria, gram-negative bacteria and fungi. Synonyms: Ixosin-B-amide; Gln-Leu-Lys-Val-Asp-Leu-Trp-Gly-Thr-Arg-Ser-Gly-Ile-Gln-Pro-Glu-Gln-His-Ser-Ser-Gly-Lys-Ser-Asp-Val-Arg-Arg-Trp-Arg-Ser-Arg-Tyr-NH2. Grades: 97.2%. Molecular formula: C165H263N57O48. Mole weight: 3813.2. | |
| I-XW-053 | I-XW-053 is an inhibitor of HIV-1 capsid protein that can suppress the replication of HIV-189BZ167 with an IC 50 value of 164.2 μM. I-XW-053 exhibits antiviral activity and can block the interface between capsid protein (CA) N-terminal domains (NTD-NTD interface) with micromolar affinity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 5496-35-5. Pack Sizes: 10 mM * 1 mL; 250 mg; 1 g; 5 g. Product ID: HY-103078. | |
| Izonsteride | Izonsteride, a benzothiazolyl derivative, has been found to be a cholestenone 5-alpha reductase inhibitor that was once studied in prostate cancer and probably be useful against androgenic alopecia and benign prostatic hyperplasia. Synonyms: Izonsteride; LY-320236; LY 320236; LY320236; UNII-A5E8C36F34.; (4AR,10BR)-8-[(4-ETHYL-1,3-BENZOTHIAZOL-2-YL)SULFANYL]-4,10B-DIMETHYL-1H,2H,3H,4H,4AH,5H,6H,10BH-BENZO[F]QUINOLIN-3-ONE. Grades: 98%. CAS No. 176975-26-1. Molecular formula: C24H26N2OS2. Mole weight: 422.62. | |
| Izumenolide | It is produced by the strain of Micromonospora chalcea subsp. izumensis. Izumenolide inhibited some β-lactamases, and the IC50 concentration of TEM-2 β-lactamase was 0.01 μg/mL. Synonyms: EM-4615-A; Oxacyclotriacont-3-en-2-one, 16,18-bis(sulfooxy)-30-(2-(sulfooxy)-9-undecenyl)-. CAS No. 76265-39-9. Molecular formula: C40H74O14S3. Mole weight: 875.20. | |
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