A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
ISS610 is a Signal transducer and activator of transcription 3 (STAT3) inhibitor. Reported has shown that aberrant activation of oncogenic signal transducer and activator of STAT3 protein signaling pathways is implicated in human cancers. Uses: Cancer. Synonyms: ((S)-2-(4-cyanobenzamido)-3-(4-(phosphonooxy)phenyl)propanoyl)-L-leucine. Grades: 98%. CAS No. 725233-55-6. Molecular formula: C23H26N3O8P. Mole weight: 503.45.
Istamycin A
Istamycin A is produced by the strain of Str. tenjimariensis S5-939. It has strong anti-gram positive and negative bacteria action, and Istamycin B has stronger antibacterial activity than A. Synonyms: Sannamycin A; Antibiotic KA 7038I; L-chiro-Inositol, 4-amino-1-((aminoacetyl)methylamino)-3-O-(2-amino-2,3,4,6-tetradeoxy-6-(methylamino)-alpha-D-erythro-hexopyranosyl)-1,4,5-trideoxy-6-O-methyl-. CAS No. 72503-79-8. Molecular formula: C17H35N5O5. Mole weight: 389.49.
Istamycin B
Istamycin B is produced by the strain of Str. tenjimariensis S5-939. It has strong anti-gram positive and negative bacteria action, and Istamycin B has stronger antibacterial activity than A. Synonyms: L-chiro-Inositol, 4-amino-1-(2-amino-N-methylacetamido)-3-O-(2-amino-6-methylamino-2,3,4,6-tetradeoxy-beta-D-lyxo-hexopyranosyl)-6-O-methyl-1,4,5-trideoxy-. CAS No. 72523-64-9. Molecular formula: C17H35N5O5. Mole weight: 389.49.
Istaroxime
Istaroxime, also called as PST 2744, is an inhibitor of sodium-potassium ATPase that exhibits the unique property of increasing SERCA2a activity. This has been demonstrated in sarcoplasmic reticulum vesicles from normal guinea pigs, where istaroxime incre. Synonyms: PST-2744; PST 2744; PST2744; Istaroxime; (3E,5S,8R,9S,10R,13S,14S)-3-(2-aminoethoxyimino)-10,13-dimethyl-1,2,4,5,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-6,17-dione3-((2-aminoethoxy)imino)androstane-6,17-dione3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochlorideIstaroxi. CAS No. 203737-93-3. Molecular formula: C21H32N2O3. Mole weight: 360.49.
Istaroxime hydrochloride
Istaroxime is a adenosine triphosphatase inhibitor, inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase). Uses: Inhibitor of na+/k+ atpase. Synonyms: PST-2744 HCl; PST 2744 HCl; PST2744 HCl(3E,5α)-3-[(2-Aminoethoxy)imino]androstane-6,17-dione hydrochloride. Grades: ≥95%. CAS No. 374559-48-5. Molecular formula: C21H33ClN2O3. Mole weight: 396.95.
Istaroxime hydrochloride
Istaroxime hydrochloride is a Na + /K + -ATPase inhibitor ( IC 50 =0.11 μM) and a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ( SERCA 2 ) activator. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PST2744 hydrochloride. CAS No. 374559-48-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15718A.
Istradefyline
Istradefyline. Group: Biochemicals. Alternative Names: (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methylxanthine,; 8-[ (1E) -2- (3, 4-Dimethoxyphenyl) ethenyl]-1, 3-diethyl-3, 7-dihydro-7-methyl-1H-purine-2, 6-dione. Grades: Highly Purified. CAS No. 155270-99-8. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. Molecular Formula: C20H24N4O4. US Biological Life Sciences.
Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist with K i of 2.2 nM in experimental models of Parkinson's disease. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KW-6002. CAS No. 155270-99-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10888.
Istradefylline
Istradefylline is a selective A(2A) antagonist used in the treatment of Parkinsons disease. Group: Biochemicals. Alternative Names: (E) -8-[2- (3, 4-Dimethoxyphenyl) ethenyl]-1, 3-diethyl-3, 7-dihydro-7-methyl-1H-Purine-2, 6-dione; Istradefylline; KW 6002. Grades: Highly Purified. CAS No. 155270-99-8. Pack Sizes: 1g. US Biological Life Sciences.
Worldwide
Istradefylline
Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist (Ki=2.2 nM). Uses: Adenosine a2 receptor antagonists. Synonyms: KW6002; KW 6002; KW-6002; Istradefylline. 8-[(1E)-2-(2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione. Grades: > 95%. CAS No. 155270-99-8. Molecular formula: C20H24N4O4. Mole weight: 384.43.
Istradefylline Dimer 2 is a dimer of Istradefylline, which is a selective A(2A) antagonist used in the treatment of Parkinson's disease. Synonyms: 8,8'-((1R,2R,3S,4S)-2,4-Bis(3,4-dimethoxyphenyl)cyclobutane-1,3-diyl)bis(1,3-diethyl-7-methyl-1H-purine-2,6(3H,7H)-dione); 1H-Purine-2,6-dione, 8,8'-[(1α,2α,3β,4β)-2,4-bis(3,4-dimethoxyphenyl)-1,3-cyclobutanediyl]bis[1,3-diethyl-3,7-dihydro-7-methyl-; Istradefylline Impurity 25. CAS No. 702697-27-6. Molecular formula: C40H48N8O8. Mole weight: 768.86.
Istradefylline Impurity 3 is one of Istradefylline impurities, a selective A(2A) antagonist used in the treatment of Parkinson's disease. Molecular formula: C19H23N3O5. Mole weight: 373.40.
Istradefylline Impurity 4
Istradefylline Impurity 4 is one of Istradefylline impurities, a selective A(2A) antagonist used in the treatment of Parkinson's disease. Molecular formula: C30H34N4O8. Mole weight: 578.61.
Istradefylline Impurity 5
Istradefylline Impurity 5 is one of Istradefylline impurities, a selective A(2A) antagonist used in the treatment of Parkinson's disease. Molecular formula: C19H22N4O6. Mole weight: 402.40.
Istradefylline Impurity 6
Istradefylline Impurity 6 is one of Istradefylline impurities, a selective A(2A) antagonist used in the treatment of Parkinson's disease. Molecular formula: C19H23N3O5. Mole weight: 373.40.
Istradefylline Impurity 7
Istradefylline Impurity 7 is one of Istradefylline impurities, a selective A(2A) antagonist used in the treatment of Parkinson's disease. CAS No. 1453190-01-6. Molecular formula: C20H24N4O4. Mole weight: 384.43.
Istradefylline Impurity 8
Istradefylline Impurity 8 is one of Istradefylline impurities, a selective A(2A) antagonist used in the treatment of Parkinson's disease. Synonyms: 3,4-Dimethoxycinnamamide; 14773-40-1; 3-(3,4-Dimethoxyphenyl)propenamide; (E)-3-(3,4-dimethoxyphenyl)prop-2-enamide; (2E)-3-(3,4-dimethoxyphenyl)prop-2-enamide; 130973-10-3; CINNAMAMIDE, 3,4-DIMETHOXY-; SCHEMBL8153880; SCHEMBL8153885; 3-(3,4-Dimethoxyphenyl)acrylamide; LT0108; AKOS003421127; NCGC00385957-01; (2E)-3-(3,4-dimethoxyphenyl)-2-propenamide; NCGC00385957-01_C11H13NO3_(2E)-3-(3,4-Dimethoxyphenyl)acrylamide. CAS No. 14773-40-1. Molecular formula: C11H13NO3. Mole weight: 207.23.
Istradefylline M8. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C20H24N4O5, Molecular Weight: 400.43. US Biological Life Sciences.
Worldwide
Istradefylline M8
Istradefylline M8 is one of Istradefylline metabolites, a selective A(2A) antagonist used in the treatment of Parkinson's disease. Synonyms: 8-[(E)-2-(3,4-Dimethoxyphenyl)vinyl]-3-ethyl-1-(2-hydroxyethyl)-7-methyl-3,7-dihydro-1H-purine-2,6-dione; 1H-Purine-2,6-dione, 8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-3-ethyl-3,7-dihydro-1-(2-hydroxyethyl)-7-methyl-; (E)-8-(3,4-dimethoxystyryl)-3-ethyl-1-(2-hydroxyethyl)-7-methyl-1H-purine-2,6(3H,7H)-dione. CAS No. 1798429-54-5. Molecular formula: C20H24N4O5. Mole weight: 400.43.
Istradefylline M8-d3,13C
Istradefylline M8-d3,13C. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C1913CH21D3N4O5, Molecular Weight: 404.44. US Biological Life Sciences.
Worldwide
Istradefylline (Standard)
Istradefylline (Standard) is the analytical standard of Istradefylline. This product is intended for research and analytical applications. Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist with K i of 2.2 nM in experimental models of Parkinson's disease. Uses: Scientific research. Group: Signaling pathways. CAS No. 155270-99-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10888R.
ISX-3
ISX-3 is a potent anti-adipogenic and pro-osteogenic agent. ISX-3 increases the expression of PPAR&gamma. ISX-3 has the potential for the research of osteopenia and osteoporosis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 912789-08-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148694.
ISX 9
ISX 9. Group: Biochemicals. Grades: Purified. CAS No. 832115-62-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
ISX-9
ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation. ISX-9 activates Ca 2+ influx through both voltage-gated Ca 2+ channels and NMDA receptors and increases neuroD expression. ISX-9 also induces cardiomyogenic differentiation of Notch-activated epicardium-derived cells (NECs) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Isoxazole 9. CAS No. 832115-62-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12323.
IT-143A
IT-143A is a bacterial metabolite produced by the strain of Streptomyces sp. IT-143. It is active against the bacterium M. luteus (MIC = 6.25 μg/ml) and the fungi A. fumigatus and T. rubrum in vitro (MICs = 12.5-25 μg/ml). Synonyms: IT-143-A. Grades: >95% by HPLC. CAS No. 183485-32-7. Molecular formula: C29H43NO4. Mole weight: 469.65.
IT-143-A
IT-143-A is produced by the strain of Streptomyces sp.IT-143. It has activity against individual gram-positive bacteria (Micrococcus gaminerae) and individual fungi (Aspergillus fumigatus). And it is also cytotoxic to KB cells. Synonyms: IT-143A. Molecular formula: C29H43NO4. Mole weight: 469.65.
IT-143-B
IT-143-B is produced by the strain of Streptomyces sp.IT-143. It has activity against individual gram-positive bacteria (Micrococcus gaminerae) and individual fungi (Aspergillus fumigatus). And it is also cytotoxic to KB cells. Synonyms: IT-143B. Grades: ≥95%. CAS No. 183485-34-9. Molecular formula: C28H41NO4. Mole weight: 455.63.
IT1t
IT1t is a selective CXCR4 antagonist with IC50 value of 1.1 nM in calcium mobilization assays.It may be potential useful as anti-HIV agent. Uses: Anti-hiv agent. Synonyms: N,N'-Dicyclohexylcarbamimidothioic Acid (5,6-Dihydro-6,6-dimethylimidazo[2,1-b]thiazol-3-yl)methyl Ester;1092776-63-0 (HCl salt). Grades: 98%. CAS No. 864677-55-4. Molecular formula: C21H34N4S2. Mole weight: 406.65.
IT1t dihydrochloride
IT1t dihydrochloride is a potent and orally CXCR4 antagonist (IC50 = 1.1 nM in calcium mobilization assays). Synonyms: N,N'-Dicyclohexylcarbamimidothioic acid (5,6-dihydro-6,6-dimethylimidazo[2,1-b]thiazol-3-yl)methyl ester dihydrochloride; IT1t; IT1t dihydrochloride. Grades: ≥98% (HPLC). CAS No. 1092776-63-0. Molecular formula: C21H34N4S2.2HCl. Mole weight: 479.57.
IT1t dihydrochloride
IT1t dihydrochloride is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4 interaction with an IC 50 of 2.1 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1092776-63-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101458A.
IT1t dihydrochloride
IT1t dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1092776-63-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
IT-62-B
IT-62-B is originally isolated from Streptomyces sp. IT-62. It had moderate anti-Gram-positive bacteria activity (MIC 6.25-12.5 μg/mL), and anti-L1210, P388, adriamycin-resistant P388 and KB tumor cells activity. Molecular formula: C39H47NO15. Mole weight: 769.79.
IT 901
IT 901, a bioactive naphthalenethiobarbiturate derivative, potently inhibits the NF-κB subunit c-Rel with IC50 value of 3 μM. It shows its anticancer properties in Hematologic Malignancies by inhibiting the oxidative stress response in lymphoma cells. It suppressed graft-versus-host disease while preserving graft-versus-lymphoma activity during allogeneic transplantation. It did not elicit increased levels of reactive oxygen species in normal leukocytes, illustrating its cancer selective properties. It is used for the treatment of human B-cell lymphoma and reveals antitumor properties in vitro and in vivo. It is also a novel therapeutic agent to ameliorate graft-versus-host disease. Synonyms: IT-901; IT 901; IT901; 5-[(2,4-Dimethoxy-1-naphthalenyl)methylene]dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione. Grades: ≥98% by HPLC. CAS No. 1584121-99-2. Molecular formula: C17H14N2O4S. Mole weight: 342.37.
I-TAC (CXCL11) from mouse
recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Itacitinib
Itacitinib (INCB039110) is an orally active and selective inhibitor of JAK1 with an IC 50 of 2 nM for human JAK1. Itacitinib shows >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2; Itacitinib is used in the research of myelofibrosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: INCB039110. CAS No. 1334298-90-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16997.
Itacitinib
Itacitinib is a potent and selective JAK1 inhibitor developed for the treatment of Graft-versus-host disease and non-small cell lung cancer. Synonyms: INCB 039110; 2-[1-[1-[3-fluoro-2-(trifluoromethyl)pyridine-4-carbonyl]piperidin-4-yl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile. Grades: >98%. CAS No. 1334298-90-6. Molecular formula: C26H23F4N9O. Mole weight: 553.51.
Itacitinib adipate
Itacitinib adipate is an orally bioavailable and selective JAK1 inhibitor which has been tested for efficacy and safety in a phase II trial in myelofibrosis. Uses: Scientific research. Group: Signaling pathways. CAS No. 1334302-63-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16997A.
Itaconic acid
1kg Pack Size. Group: Organics. Formula: C5H6O4. CAS No. 97-65-4. Prepack ID 10565984-1kg. Molecular Weight 130.1. See USA prepack pricing.
Itaconic acid
analytical standard. Group: Natural compounds.
Itaconic acid
Inhibitor of isocitrate lyase, the key enzyme of the glyoxylate cycle, essential for bacterial growth. Antimicrobial. Antibacterial. Inhibits the growth of bacteria expressing isocitrate lyase. Phosphofructokinase (PFKII) inhibitor. Suppresses glycolysis by decreasing the level of fructose 2,6-bisphosphate, resulting in decreased visceral fat. Might be involved in the regulation of metabolism. Group: Biochemicals. Alternative Names: 2-Methylenebutanedioic Acid; Methylenesuccinic Acid; 2-Methylenebutanedioic Acid; 2-Methylenesuccinic Acid; 2-Propene-1,2-dicarboxylic Acid; 4-Hydroxy-2-methylene-4-oxobutanoic Acid; Methylenebutanedioic Acid; NSC 3357; Propylenedicarboxylic Acid. Grades: Highly Purified. CAS No. 97-65-4. Pack Sizes: 1g, 5g. Molecular Formula: C?H?O?. US Biological Life Sciences.
Worldwide
Itaconic acid
Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. Itaconic acid has anti-inflammatory, anti-microbial and immunomodulatory effect [1] [2] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: Methylenesuccinic acid. CAS No. 97-65-4. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-Y0520.
Itaconic Acid
Itaconic Acid. We stock inventory in warehouses throughout the United States, allowing us to serve customers in all regions in a timely and cost effective manner.
California
Itaconic Acid
Itaconic Acid. CAS No. 97-65-4. Molecular formula: C5H6O4.
Itaconic Acid 97-65-4
Itaconic Acid - Surface Coatings. SUPPLIERS TO BUSINESS CUSTOMERS ONLY.
Itaconic acid,magnesium salt. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ITACONIC ACID, MAGNESIUM SALT;Magnesium Itaconate. Product Category: Heterocyclic Organic Compound. CAS No. 69064-18-2. Molecular formula: C5H4MgO4. Mole weight: 152.39. Product ID: ACM69064182. Alfa Chemistry ISO 9001:2015 Certified.
100g Pack Size. Group: Building Blocks, Organics. Formula: C5H4O3. CAS No. 2170-3-8. Prepack ID 89996186-100g. Molecular Weight 112.08. See USA prepack pricing.
Itaconic anhydride
Itaconic anhydride. Group: Biochemicals. Alternative Names: 3,4-Dihydro-3-methylene-2,5-furandione; Methylenesuccinic anhydride. Grades: Highly Purified. CAS No. 2170-3-8. Pack Sizes: 100g, 250g, 500g, 1kg, 2kg. Molecular Formula: C5H4O3. US Biological Life Sciences.
Worldwide
Itaconic Anhydride
Itaconic anhydride (ITA) is a biobased material that is obtained from renewable resources. It is produced from the pyrolysis of citric acid or by fermenting carbohydrates which forms itanoic acid. Itanoic acid can be dehydrated to form an anhydride. It is relatively more reactive that maleic anhydride and can be used as an alternating monomer that facilitates the introduction of polar functionalities in polymers. Uses: Ita can be copolymerized with methacrylate terminated poly(lactic acid) (pla) for potential usage in packaging and biomedical s. it can also facilitate the production of reactive polyesters which can be used as starting materials in telechelics, cross-linking agents and macromonomers. Additional or Alternative Names: 3-methyleneoxolane-2,5-dione; 3-methylideneoxolane-2,5-dione. Product Category: Polymer/MacromoleculeAnhydride Monomers. Appearance: White to Cream Crystalline Powder. CAS No. 2170-3-8. Molecular formula: C5H4O3. Mole weight: 112.08 g/mol. Purity: 0.97. Canonical SMILES: C=C1CC(=O)OC1=O. ECNumber: 218-518-2. Product ID: ACM-MO-2170038. Alfa Chemistry ISO 9001:2015 Certified.
Itaconic Anhydride 2170-03-8
Itaconic Anhydride - Surface Coatings. SUPPLIERS TO BUSINESS CUSTOMERS ONLY.
North America & APAC
itaconyl-CoA hydratase
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. This enzyme participates in c5-branched dibasic acid metabolism. Group: Enzymes. Synonyms: itaconyl coenzyme A hydratase; citramalyl-CoA hydro-lyase. Enzyme Commission Number: EC 4.2.1.56. CAS No. 37290-83-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5045; itaconyl-CoA hydratase; EC 4.2.1.56; 37290-83-8; itaconyl coenzyme A hydratase; citramalyl-CoA hydro-lyase. Cat No: EXWM-5045.
ITD 1
ITD 1. Group: Biochemicals. Grades: Purified. CAS No. 1099644-42-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
ITD-1
ITD-1 is an effective and highly selective TGF-β signaling inhibitor. It promotes differentiation of cardiomyocytes from embryonic stem cells (ESCs) via TGF-β type II receptor degradation. Uses: Itd-1 is an effective and highly selective tgf-β signaling inhibitor so that it might have potential application prospectin in immunity therapy. Synonyms: ITD 1; ethyl 2,7,7-trimethyl-5-oxo-4-(4-phenylphenyl)-1,4,6,8-tetrahydroquinoline-3-carboxylate. Grades: >98%. CAS No. 1099644-42-4. Molecular formula: C27H29NO3. Mole weight: 415.52.
ITE
ITE is an Aryl hydrocarbon receptor ligand that acts as an endogenous aryl hydrocarbon receptor (AhR) agonist (Ki = 3 nM). Uses: Endogenous aryl hydrocarbon receptor (ahr) agonist. Synonyms: 2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester. Grades: ≥98 %. CAS No. 448906-42-1. Molecular formula: C14H10N2O3S. Mole weight: 286.31.
ITE
ITE is a potent endogenous agonist of aryl hydrocarbon receptor ( AhR ), binding directly to AHR , with a K i of 3 nM. ITE also has immunosuppressive activity. Uses: Scientific research. Group: Signaling pathways. CAS No. 448906-42-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19317.
Itepekimab
Itepekimab (REGN-3500) is an IgG4 monoclonal antibody against IL-33. Itepekimab reduced airway inflammation and related tissue damage in preliminary clinical studies. Itepekimab has potential effects in asthma, chronic obstructive pulmonary disease (COPD), and atopic dermatitis (AD) [1] [2] [3] [4]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: REGN-3500; SAR-440340. CAS No. 2226742-52-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99673.
ITH 12575, a potent and selective inhibitor of mitochondrial Na+/Ca2+ exchange (mNCX) inhibitor, reduced Ca(2+) influx through CALHM1 at low micromolar concentrations. It can be used to study the physiological roles of the mitochondrial sodium /calcium exchanger related to neurodegeneration. Synonyms: ITH-12575; ITH 12575; ITH12575; 7-Chloro-1,5-dihydro-5-[2-(1-methylethyl)phenyl]-4,1-benzothiazepin-2(3H)-one; ITH-12575; ITH12575. Grades: ≥98% by HPLC. CAS No. 1802013-08-6. Molecular formula: C18H18ClNOS. Mole weight: 331.86.
ITI214
ITI214 is a highly selective PDE1 inhibitor (Ki = 58 pM) at picomolar concentration without disrupting other PDE family members and a panel of enzymes, receptors, transporters, and ion channels. Synonyms: Lenrispodun phosphate; PDE1-IN-1 (phosphate); ITI 214; ITI-214. CAS No. 1642303-38-5. Molecular formula: C29H29FN7O5P. Mole weight: 605.56.
ITI-214
ITI-214 is a potent, CNS-active, orally bioavailable PDE1 inhibitor ( K i of 58 pM) with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters and ion channels. ITI-214 inhibits recombinant full-length human PDE1A, PDE1B and PDE1C with K i s of 33 pM, 380 pM and 35 pM, respectively. ITI-214 shows efficacy in various animal models of motor and cognitive functions [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1642303-38-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-12501A.