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| Product | Description | |
|---|---|---|
| JNJ16259685 | JNJ16259685 is a selective antagonist of mGlu1 receptor , and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC 50 of 19 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 409345-29-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100407. |  |
| JNJ 16259685 | JNJ 16259685, a pyrano-quinolin derivative, has been found to be a metabotropic glutamate receptor-1 antagonist. Synonyms: JNJ16259685; JNJ 16259685; JNJ-16259685; (3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone. Grades: ≥98% by HPLC. CAS No. 409345-29-5. Molecular formula: C20H23NO3. Mole weight: 325.41. |  |
| JNJ 16259685 | JNJ 16259685. Group: Biochemicals. Alternative Names: (3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)(cis-4-methoxycyclohexyl)-methanone. Grades: Highly Purified. CAS No. 409345-29-5. Pack Sizes: 10mg. Molecular Formula: C20H23NO3, Molecular Weight: 325.399999999999. US Biological Life Sciences. |  Worldwide |
| JNJ 1661010 | JNJ 1661010. Group: Biochemicals. Grades: Purified. CAS No. 681136-29-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| JNJ-1661010 | JNJ-1661010 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 10 nM (rat) and 12 nM (human), exhibits >100-fold selectivity for FAAH-1 when compared to FAAH-2. Synonyms: Takeda-25; N1-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide; JNJ 1661010; JNJ1661010; N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide. Grades: ≥98%. CAS No. 681136-29-8. Molecular formula: C19H19N5OS. Mole weight: 365.45. | |
| JNJ 17029259 | JNJ 17029259 is an selective, nanomolar inhibitors of the vascular endothelial growth factor receptor-2 (VEGF-R2), blocks VEGF-stimulated mitogen-activated protein kinase signaling, proliferation/migration. Uses: Vascular endothelial growth factor receptor-2 (vegf-2) kinase inhibitor. Synonyms: JNJ-17029259; JNJ 17029259; JNJ17029259. 4-[4-(2-aminopropan-2-yl)phenyl]-2-[4-(2-morpholin-4-ylethyl)anilino]pyrimidine-5-carbonitrile. Grades: ≥98%. CAS No. 314267-57-7. Molecular formula: C26H30N6O. Mole weight: 442.56. | |
| JNJ17156516 | JNJ17156516 is a potent, novel and selective cholecystokinin 1 receptor antagonist. It showed high-affinity at the cloned human and canine CCK1 receptors. It was also highly selective for the CCK1 receptor compared with the CCK2 receptor across the same species. Synonyms: JNJ-17156516; JNJ 17156516; JNJ17156516; (S)-3-(5-(3,4-Dichlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl)-2-(3-methylphenyl)propionic acid. Grades: 98%. CAS No. 649551-06-4. Molecular formula: C26H22Cl2N2O3. Mole weight: 481.37. | |
| JNJ17156516 sodium | JNJ17156516 sodium is the sodium salt form of JNJ17156516, which is a potent, novel and selective cholecystokinin 1 receptor antagonist. It showed high-affinity at the cloned human and canine CCK1 receptors. It was also highly selective for the CCK1 receptor compared with the CCK2 receptor across the same species. Synonyms: JNJ-17156516 sodium; JNJ 17156516 sodium; JNJ17156516 sodium; 1H-Pyrazole-3-propanoic acid, 5-(3,4-dichlorophenyl)-1-(4-methoxyphenyl)-alpha-(3-methylphenyl)-, sodium salt (1:1), (alphaS)-;(S)-3-(5-(3,4-Dichlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl)-2-(3-methylphenyl)propionic acid sodium s. Grades: 98%. CAS No. 648861-58-9. Molecular formula: C26H21Cl2N2NaO3. Mole weight: 503.35. | |
| JNJ 17203212 | JNJ 17203212. Group: Biochemicals. Grades: Purified. CAS No. 821768-06-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| JNJ-17203212 | JNJ-17203212 is a selective, potent and competitive TRPV1 antagonist. JNJ-17203212 is developed for researching pain management, such as migraine [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 821768-06-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100129. | |
| JNJ-17203212 | JNJ-17203212 is a novel, reversible, and selective TRPV1 antagonist which could not inhibit related TRP channels. Its IC50 values are 65 nM and 102 nM for human TRPV1 and rat TRPV1. It could reduce sensitivity to luminal distension in both an acute, noninflammatory and a chronic, post-inflammatory rodent model of colonic hypersensitivity. It inhibits capsaicin- and H+-induced channel activation, which pIC50 values are 6.32 and 7.23 respectively. It exhibits antitussive and analgesic activity in vivo. Uses: Jnj-17203212 could reduce sensitivity to luminal distension in both an acute, noninflammatory and a chronic, post-inflammatory rodent model of colonic hypersensitivity. it inhibits capsaicin- and h+-induced channel activation. it exhibits antitussive and analgesic activity in vivo. Synonyms: JNJ-17203212; JNJ 17203212; JNJ17203212. 4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide;1-PiperazinecarboxaMide, 4-[3-(trifluoroMethyl)-2-pyridinyl]-N-[5-(trifluoroMethyl)-2-pyridinyl]-;N1-(3-Trifluoromethylpyrid-2-yl)-N4-(4-trifluoromethylpyrid-2-yl)carbamoylpiperazine. Grades: >99 %. CAS No. 821768-06-3. Molecular formula: C17H15F6N5O. Mole weight: 419.32. | |
| JNJ-18038683 | JNJ-18038683 is a 5-Hydroxytryptamine Type 7 ( 5-HT 7 ) receptor antagonist, with pK i s of 8.19, 8.20 for rat and human 5-HT 7 in HEK293 cells, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 851376-05-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19889. | |
| JNJ-19567470 | JNJ-19567470 is a selective Corticotropin releasing factor (CRF) receptor antagonist. It is a novel target for developing anti-panic drugs. JNJ-19567470 is as effective as benzodiazepines in treatment of a panic attack which prevents sodium lactate-induced acute panic-like responses. In Oct 2009, preclinical development in Anxiety disorders was ongoing in Japan. Uses: Anxiety disorders. Synonyms: JNJ-19567470; JNJ19567470; JNJ 19567470; TAI-041; TAI 041; TAI041; R-317573;1-(7-(4-bromo-2,6-dimethylphenyl)-2,5-dimethyl-7H-pyrrolo(2,3-d)pyrimidin-4-yl)-4-Piperidinemethanol. Grades: 98%. CAS No. 724471-26-5. Molecular formula: C22H27BrN4O. Mole weight: 443.38. | |
| JNJ 20788560 | JNJ-20788560 is a delta opioid agonist analgesics. No recent reports of development identified for preclinical development in Inflammatory-pain in USA. Uses: Inflammatory pain; pain. Synonyms: JNJ-20788560; JNJ 20788560; JNJ20788560; 9-(8-Azabicyclo(3.2.1)oct-3-ylidene)-9H-xanthene-3-carboxylic acid diethylamide. Grades: 98%. CAS No. 825649-28-3. Molecular formula: C25H28N2O2. Mole weight: 388.51. | |
| JNJ-2408068 | JNJ-2408068 is a potent inhibitor of respiratory syncytial virus (RSV), exhibits potent antiviral activity with 50% effective concentrations (EC50s) of 1.4 and 2.1 nM, respectively. Uses: Respiratory syncytial virus inhibitor. Synonyms: R170591; R-170591; R 170591; HE066500; HE-066500; HE 066500; JNJ-2408068; JNJ 2408068; JNJ2408068. 2-[[2-[[1-(2-aminoethyl)piperidin-4-yl]amino]-4-methylbenzimidazol-1-yl]methyl]-6-methylpyridin-3-ol. Grades: ≥98%. CAS No. 317846-22-3. Molecular formula: C22H30N6O. Mole weight: 394.52. | |
| JNJ26076713 | JNJ26076713 is an orally active alpha V integrin antagonist. It may be a potential therapeutic candidate for the treatment of age-related macular degeneration,proliferative diabetic retinopathy and macular edema. Uses: Jnj26076713 may be a potential therapeutic candidate for the treatment of age-related macular degeneration,proliferative diabetic retinopathy and macular edema. Synonyms: JNJ-26076713; JNJ26076713; JNJ 26076713;3-Quinolinepropanoic acid, 1,2,3,4-tetrahydro-beta-((1-(1-oxo-3-(1,5,6,7-tetrahydro-1,8-naphthyridin-2-yl)propyl)-4-piperidinyl)methyl)-, (betaS,3S)-;(3S)-4-[1-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propanoyl]piperidin-4-yl]-3-[(3S)-1,2. Grades: 98%. CAS No. 669076-03-3. Molecular formula: C29H38N4O3. Mole weight: 490.65. | |
| JNJ-26146900 | JNJ-26146900 is a selective, nonsteroidal androgen receptor modulator with tissue-selective activity in rats. It can bind to the rat AR with a Ki of 400nM and act as a pure androgen antagonist in an in vitro cell-based assay. But no development was reported for the treatment of Bone disorders and Cancer till now. Uses: Bone disorders; cancer. Synonyms: JNJ-26146900; JNJ 26146900; JNJ26146900. (-)(R)-2-(2-Ethylsulfonyl-1-hydroxy-1-methylethyl)-6-trifluoromethyl-1H-indole-5-carbonitrile. Grades: 98%. CAS No. 868691-50-3. Molecular formula: C15H15F3N2O3S. Mole weight: 360.35. | |
| JNJ 26481585 dihydrochloride | JNJ 26481585 dihydrochloride is a potent and second-generation pan-HDAC inhibitor (IC50 value 0.11 nM for HDAC1, and sub-nanomolar for HDAC2, HDAC4, HDAC10, and HDAC11 in vitro) with antineoplastic activity. JNJ-26481585 inhibiting HDAC leads to continuous acetylation of histone H3, activation of the caspase cascade, upregulation of p21, and tumor cell apoptosis. Uses: Antitumor agent. Synonyms: JNJ 26481585 dihydrochloride; JNJ26481585 dihydrochloride; JNJ-26481585 dihydrochloride; Quisinostat HCl; N-hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)methyl)piperidin-1-yl)pyrimidine-5-carboxamide dihydrochloride. Grades: 99%. CAS No. 875320-31-3. Molecular formula: C21H26N6O2.2HCl. Mole weight: 467.39. | |
| JNJ-26483327 | JNJ-26483327 is an orally bioavailable, small-molecule, multitargeted reversible tyrosine kinase inhibitor with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor JNJ-26483327 binds to and inhibits several members of the epidermal growth factor receptor (EGFR) family, including EGFR, HER2 and HER4; Src family kinases (Lyn, Yes, Fyn, Lck and Src); and vascular endothelial growth factor receptor type 3 (VEGFR3). By inhibiting several different signaling molecules that play crucial roles at various stages in tumorigenesis, this agent may inhibit tumor growth, invasion, migration and metastasis. In addition, JNJ-26483327 crosses the blood-brain barrier (BBB). Synonyms: JNJ-26483327; JNJ 26483327; JNJ26483327. CAS No. 807640-87-5. Molecular formula: C22H25BrN4O2. Mole weight: 457.372. | |
| JNJ26483327 dihydrobromide | JNJ26483327 is an orally bioavailable multitargeted reversible tyrosine kinase inhibitor. It binds to and inhibits several members of the epidermal growth factor receptor (EGFR) family, Src family kinases and vascular endothelial growth factor receptor type 3 (VEGFR3). It has potential antineoplastic activity. It may inhibit tumor growth, invasion, migration and metastasis by inhibiting several different signaling molecules. Uses: Jnj26483327 has potential antineoplastic activity and may inhibit tumor growth, invasion, migration and metastasis. Synonyms: (Z)-35-bromo-17-methoxy-5-methyl-13,14-dihydro-11-oxa-2,5-diaza-1(4,6)-quinazolina-3(1,2)-benzenacycloundecaphane;JNJ 26483327; JNJ-26483327; JNJ26483327. Grades: >98 %. CAS No. 1021686-80-5. Molecular formula: C22H27Br3N4O2. Mole weight: 619.19. | |
| JNJ-26489112 | JNJ-26489112 is a CNS active agent that can be used to treat depression and photosensitive epilepsy. Synonyms: JNJ26489112; JNJ 26489112. CAS No. 871824-55-4. Molecular formula: C9H11ClN2O4S. Mole weight: 278.71. | |
| JNJ 26854165 dihydrochloride | JNJ 26854165 dihydrochloride is a HDM2 inhibitor. It potently inhibits multiple myeloma (MM) cells and mantle cell lymphoma (MCL). In addition, JNJ 26854165 suppresses the mutant (mut) p53 cell lines and results in apoptosis. Synonyms: Serdemetan dihydrochloride; N1-(2-(1H-indol-3-yl)ethyl)-N4-(pyridin-4-yl)benzene-1,4-diamine dihydrochloride. Grades: 99%. CAS No. 2109414-74-4. Molecular formula: C21H20N4.2HCl. Mole weight: 401.33. | |
| JNJ 27141491 | JNJ 27141491 is a potent and selective human CCR2 antagonist. Synonyms: JNJ27141491; JNJ 27141491; JNJ-27141491; 4,4-difluoro-N-((1S)-3-(exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo(3.2.1)oct-8-yl)-1-phenylpropyl)cyclohexanecarboxamide; maraviroc; Pfizer Brand of maraviroc; Selzentry; UK-427,857; UK-427857. CAS No. 871313-59-6. Molecular formula: C17H15F2N3O3S. Mole weight: 379.38. | |
| JNJ 27141491 | JNJ 27141491. Group: Biochemicals. Grades: Purified. CAS No. 871313-59-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| JNJ-28312141 | JNJ-28312141 is an orally active CSF1R inhibitor (Colony-stimulating factor-1 receptor, CRF1R) and also a FLT3 inhibitor. CSF1R is expressed by many tumors and is a growth factor for macrophages and mediates osteoclast differentiation. JNJ-28312141 represents a new agent with potential therapeutic activity in acute myeloid leukemia and in settings where CSF-1-dependent macrophages and osteoclasts contribute to tumor growth and skeletal events. Synonyms: JNJ28312141; JNJ 28312141; 4-cyano-N-(5-(1-(2-(dimethylamino)acetyl)piperidin-4-yl)-2',3',4',5'-tetrahydro-[1,1'-biphenyl]-2-yl)-1H-imidazole-2-carboxamide. CAS No. 885692-52-4. Molecular formula: C26H32N6O2. Mole weight: 460.58. | |
| JNJ 28871063 hydrochloride | The hydrochloride salt form of JNJ 28871063, which has been found to be a nonquinazoline Pan-ErbB kinase inhibitor and probably could restrain the growth of human tumor xenografts. Synonyms: JNJ28871063 hydrochloride; JNJ-28871063 hydrochloride; 5E-4-Amino-6-(4-benzyloxy-3-chlorophenylamino)pyrimidine-5-carboxaldehyde N-(2-morpholin-4-ylethyl) oxime hydrochloride; 5-Pyrimidinecarboxaldehyde, 4-amino-6-[[3-chloro-4-(phenylmethoxy)phenyl]amino]-, O-[2-(4-morpholinyl)ethyl]oxime, hydrochloride (1:1), [C(E)]-; JNJ 28871063; (E)-4-amino-6-((4-(benzyloxy)-3-chlorophenyl)amino)pyrimidine-5-carbaldehyde O-(2-morpholinoethyl) oxime hydrochloride. Grades: ≥97% by HPLC. CAS No. 944342-90-9. Molecular formula: C24H27ClN6O3.HCl. Mole weight: 519.42. | |
| JNJ 28871063 hydrochloride | JNJ 28871063 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 944342-90-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| JNJ 303 | JNJ 303 has been found to be a potent IKs blocker (IC50 = 64 nM) as well as a 11β-HSD1 inhibitor. Synonyms: JNJ303; JNJ-303; JNJ 303; AC-1; AC 1; AC1; 2-(4-Chlorophenoxy)-2-methyl-N-[5-[(methylsulfonyl)amino]tricyclo[3. 3. 1. 13, 7]dec-2-yl]-propanamide. Grades: ≥98% by HPLC. CAS No. 878489-28-2. Molecular formula: C21H29ClN2O4S. Mole weight: 440.98. | |
| JNJ-31020028 | JNJ-31020028 is a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptor. JNJ-31020028 bound with high affinity (IC50 = 8.07, human) and was 100-fold selective versus human Y(1), Y(4), and Y(5) receptors. JNJ-31020028 was demonstrated to be an antagonist (pK(B) = 8.04) in functional assays. Synonyms: JNJ31020028; JNJ 31020028; JNJ-31020028. Grades: 98%. CAS No. 1094873-14-9. Molecular formula: C34H36FN5O2. Mole weight: 565.6. | |
| JNJ-37822681 dihydrochloride | JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D 2 receptor antagonist with a moderate binding affinity for the dopamine D 2L receptor ( K i =158 nM), which has potential for the treatment of schizophrenia and bipolar disorder [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2108806-02-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111066A. | |
| JNJ-37822681 dihydrochloride | JNJ-37822681 dihydrochloride is a potent, specific, centrally active and fast-dissociating antagonist of dopamine D2 receptor with a moderate binding affinity to dopamine D2L receptor (Ki = 158 nM). It has the potential to treat schizophrenia and bipolar disorder. Synonyms: 3-Pyridazinamine, N-(1-((3,4-difluorophenyl)methyl)-4-piperidinyl)-6-(trifluoromethyl)-, hydrochloride (1:2); N-(1-(3,4-difluorobenzyl)piperidin-4-yl)-6-(trifluoromethyl)pyridazin-3-amine dihydrochloride; N-[1-(3,4-Difluorobenzyl)-4-piperidinyl]-6-(trifluoromethyl)-3-pyridazinamine dihydrochloride. Grades: ≥98%. CAS No. 2108806-02-4. Molecular formula: C17H19Cl2F5N4. Mole weight: 445.26. | |
| JNJ-38877605 | JNJ-38877605 is an ATP-competitive inhibitor of c-Met with IC50 of 4 nM, 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases. Synonyms: JNJ-38877605; JNJ 38877605; JNJ38877605. Grades: >98%. CAS No. 943540-75-8. Molecular formula: C19H13F2N7. Mole weight: 377.36. | |
| JNJ-38877605 | JNJ-38877605 is an orally active ATP-competitive inhibitor of c-Met with an IC 50 of 4 nM, 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases [1] [2]. JNJ-38877605 inhibits c-Met phosphorylation and regulates lipid accumulation. JNJ-38877605 can be used for tumor and metabolic disease reseach [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 943540-75-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50683. | |
| JNJ-38877618 | JNJ-38877618 is a potent and selective inhibitor of hepatocyte growth factor receptor (HGFR; MET) that exhibits inhibitory effects against solid tumors. Synonyms: OMO-1; HY-111050; 6-[Difluoro-(6-pyridin-4-yl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl]quinoline. CAS No. 943540-74-7. Molecular formula: C20H12F2N6. Mole weight: 374.35. | |
| JNJ-39327041 | JNJ-39327041 is a bio-active chemical compound. Synonyms: JNJ-39327041; JNJ 39327041; JNJ39327041. N-[(4R)-4-(3,4-dimethoxyphenyl)-4-[7-(4-ethylpiperazin-1-yl)-3-oxo-1H-isoindol-2-yl]butyl]-1,2-dimethylimidazole-4-sulfonamide;JNJ39327041;1H-Imidazole-4-sulfonamide, N-((4R)-4-(3,4-dimethoxyphenyl)-4-(4-(4-ethyl-1-piperazinyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl)butyl)-1,2-dimethyl-. Grades: 95%. CAS No. 1093069-32-9. Molecular formula: C31H42N6O5S. Mole weight: 610.77. | |
| JNJ-39758979 dihydrochloride | JNJ-39758979 is a potent and selective histamine H4 antagonist (Ki = 12.5 nM) with >80-fold selectivity for H4 over other histamine receptors. It was shown to inhibit histamine-induced pruritus in healthy subjects. Synonyms: 4-[(3R)-3-Amino-1-pyrrolidinyl]-6-(1-methylethyl)-2-pyridinamine dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1620648-30-7. Molecular formula: C11H19N5·2HCl. Mole weight: 294.22. | |
| JNJ-39933673 hemihydrate | TA-1887 is a selective Sodium Glucose Cotransporter 2 Inhibitor with pronounced antihyperglycemic effects in high-fat diet-fed KK (HF-KK) mice. It may be used for treatment of Type 2 Diabetes in the future. Uses: Type 2 diabetes. Synonyms: JNJ-39933673 hemihydrate; TA-1887 hemihydrate; JNJ 39933673 hemihydrate; TA 1887 hemihydrate; JNJ39933673 hemihydrate; TA1887 hemihydrate; (2R,3R,4S,5S,6R)-2-(3-(4-cyclopropylbenzyl)-4-fluoro-1H-indol-1-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol hemihydrate;1003005-29-5(Free). Grades: 98%. CAS No. 1404307-42-1. Molecular formula: 2(C24H26FNO5).H2O. Mole weight: 872.95. | |
| JNJ-40355003 | JNJ-40355003 is a selective fatty acid amide hydrolase (FAAH) inhibitor. JNJ-40355003 can elevate the plasma levels of anandamide, oleoyl ethanolamide, and palmitoyl ethanolamide in animal model. Synonyms: JNJ-40355003; JNJ 40355003; JNJ40355003; 4-((3-(4-chlorophenoxy)phenyl)methyl)-N-3-pyridinyl-1-Piperazinecarboxamide. Grades: 98%. CAS No. 1394894-41-7. Molecular formula: C23H23ClN4O2. Mole weight: 422.91. | |
| JNJ-40411813 | JNJ-40411813, also known as ADX71149, is a positive allosteric modulator of the mGlu2 receptor. JNJ-40411813 acts as a PAM at the cloned mGlu2 receptor: EC50=147 ± 42 nmol/L in a [(35)S]GTPγS binding assay with human metabotropic glutamate type 2 (hmGlu2) CHO cells and EC50=64 ± 29 nmol/L in a Ca(2+) mobilization assay with hmGlu2 G α16 cotransfected HEK293 cells. JNJ-40411813 displaced [(3)H]JNJ-40068782 and [(3)H]JNJ-46281222 (mGlu2 receptor PAMs), while it failed to displace [(3)H]LY341495 (a competitive mGlu2/3 receptor antagonist). JNJ-40411813 is an interesting candidate to explore the therapeutic potential of mGlu2 PAMs, in in vivo rodents experiments as well as in clinical studies. Group: Others. Alternative Names: JNJ-40411813; JNJ 40411813; JNJ40411813; ADX71149; ADX 71149; ADX-71149. CAS No. 1127498-03-6. Molecular formula: C20H25ClN2O. Mole weight: 344.88. Appearance: Solid powder. Purity: >98%. IUPACName: 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone. Canonical SMILES: ClC1=C (N2CCC (C3=CC=CC=C3)CC2)C=CN (CCCC)C1=O. Catalog: ACM1127498036. |  |
| JNJ-40411813 | JNJ-40411813 is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM. Synonyms: JNJ-40411813; JNJ 40411813; JNJ40411813; ADX71149; ADX 71149; ADX-71149. Grades: >98%. CAS No. 1127498-03-6. Molecular formula: C20H25ClN2O. Mole weight: 344.88. | |
| JNJ-40418677 | JNJ-40418677 is an orally active modulator of γ-secretase , can cross the blood-brain barrier. JNJ-40418677 inhibits Aβ42 and NS2B-NS3 protease , with IC 50 s of 200 nM and 3.9 μM, respectively. JNJ-40418677 displays good biological tolerance, can be use for Alzheimers disease research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1146594-87-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100604. | |
| JNJ-41443532 | This active molecular is a CCR2 receptor antagonist which is applicated for the treatment of type-2 diabetes mellitus under the development of Janssen Research & Development. In 2010, Phase-I clinical trials in Type-2 diabetes mellitus was on-going. in Belgium and USA. Uses: Type-2 diabetes mellitus. Synonyms: JNJ-41443532; JNJ 41443532; JNJ41443532; JNJ-41443532 Free Base; N-(2-((1-(trans-4-hydroxy-4-(5-thiazolyl)cyclohexyl)-3-azetidinyl)amino)-2-oxoethyl)-3-(trifluoromethyl)Benzamide. Grades: 98%. CAS No. 1228650-83-6. Molecular formula: C22H25F3N4O3S. Mole weight: 482.52. | |
| JNJ-41443532 | JNJ-41443532 (CCR2 antagonist 5) is a selective, orally active hCCR2 inhibitor with good binding affinity ( IC 50 =37 nM) and potent functional antagonism ( chemotaxis IC 50 =30 nM). JNJ-41443532 displays a K i of 9.6 μM for mCCR2 binding. JNJ-41443532 can be used in the research of inflammatory disease [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CCR2 antagonist 5. CAS No. 1228650-83-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13499. | |
| JNJ-42041935 | JNJ-42041935 is a potent, competitive and selective inhibitor of prolyl hydroxylase PHD ; inhibits PHD1, PHD2, and PHD3 with pK i values of 7.91±0.04, 7.29 ±0.05, and 7.65±0.09, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1193383-09-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12832. | |
| JNJ-42041935 | JNJ-42041935 is a potent (pK(I) = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes. JNJ-42041935 is a new pharmacological tool, which can investigate PHD inhibition and demonstrate that PHD inhibitors offer great promise for the treatment of inflammation-induced anemia. Synonyms: JNJ-42041935; JNJ 42041935; JNJ42041935. Grades: 98%. CAS No. 1193383-09-3. Molecular formula: C12H6ClF3N4O3. Mole weight: 346.65. | |
| JNJ-42153605 | JNJ-42153605 is a potent and selective mGlu2 receptor positive allosteric modulator with an EC50 of 17 nM. Group: Fluorinated apis. Alternative Names: 3-(Cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1, 2, 4]triazolo[4, 3-a]pyridine. CAS No. 1254977-87-1. Molecular formula: C22H23F3N4. Mole weight: 400.45. Appearance: White to off-white solid powder. Purity: >98%. IUPACName: 3-(cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1, 2, 4]triazolo[4, 3-a]pyridine. Catalog: OFC1254977871. | |
| JNJ-42153605 | JNJ-42153605 is a selective positive allosteric modulator of the metabotropic glutamate 2 (mGlu2) receptor (EC50 = 17 Nm) with an acceptable pharmacokinetic profile in rodent and nonrodent species. Synonyms: 3-(cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine; 3-cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl(1,2,4)triazolo(4,3-a)pyridine; JNJ-42153605; JNJ 42153605; JNJ42153605. CAS No. 1254977-87-1. Molecular formula: C22H23F3N4. Mole weight: 400.44. | |
| JNJ-42165279 | JNJ-42165279 is a fatty acid amide hydrolase (FAAH) inhibitor developed by Janssen Pharmaceutica and IC50 value is 70 nM. It is described as a covalently binding but slowly reversible selective inhibitor of FAAH. Phase II human trials for the treatment of anxiety disorders and major depressive disorder is on-going. Uses: Anxiety disorders and major depressive disorder. Synonyms: N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methyl)piperazine-1-carboxamide; JNJ-42165279; JNJ 42165279; JNJ42165279. Grades: 98%. CAS No. 1346528-50-4. Molecular formula: C18H17ClF2N4O3. Mole weight: 410.81. | |
| JNJ-42165279 | JNJ-42165279 is an orally active FAAH inhibitor, with IC 50 values of 70 nM for hFAAH and 313 nM for rFAAH. JNJ-42165279 can be used in research related to the field of neuropathic pain [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1346528-50-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19636. | |
| JNJ-42165279 hydrochloride | JNJ-42165279 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor. JNJ-42165279 covalently inactivates the FAAH enzyme, but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. Synonyms: JNJ-42165279 hydrochloride; JNJ 42165279 hydrochloride; JNJ42165279 hydrochloride; 1-Piperazinecarboxamid?e, N-(4-chloro-3-pyridinyl)?-4-[(2,?2-difluoro-1,?3-benzodioxol-5-yl)?methyl]?-, hydrochloride (1:1). CAS No. 1346528-52-6. Molecular formula: C18H17ClF2N4O3. HCl. Mole weight: 447.3. | |
| JNJ-42259152 | This molecular is a phosphodiesterase 10A PET tracer. Related studies show that PDE10A activity can be reliably quantified and simplified using a reference tissue model with the frontal cortex as reference and a 60-min acquisition period. Uses: Phosphodiesterase 10a pet tracer. Synonyms: JNJ-42259152; JNJ 42259152; JNJ42259152. UNII-B1QHA9M0I6;2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)-3,5-dimethylpyridine. Grades: 98%. CAS No. 1301167-87-2. Molecular formula: C24H23FN4O. Mole weight: 402.46. | |
| JNJ 42396302 | JNJ 42396302 is an Antipsychotics originated by Janssen-Cilag. But no development has been reported yet. Uses: Antipsychotics. Synonyms: JNJ 42396302; JNJ42396302; JNJ-42396302. UNII-P5M4972608;3-(6-(2-methoxyethyl)-3-pyridinyl)-2-methyl-8-(4-morpholinyl)-Imidazo(1,2-b)pyridazine. Grades: 98%. CAS No. 1298030-18-8. Molecular formula: C19H23N5O2. Mole weight: 352.43. | |
| JNJ4796 | JNJ4796 is an oral active influenza virus fusion inhibitor. Synonyms: EZ7; JNJ-4796; JNJ 4796. Grades: 98%. CAS No. 2241664-16-2. Molecular formula: C28H27N9O3. Mole weight: 537.6. | |
| JNJ 47965567 | JNJ 47965567 has been found to be a selective P2X7 antagonist and is brain penetrant. Synonyms: JNJ-47965567; JNJ 47965567; JNJ47965567. 2-(Phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl-3-pyridinecarboxamide. Grades: ≥98% by HPLC. CAS No. 1428327-31-4. Molecular formula: C28H32N4O2S. Mole weight: 488.64. | |
| JNJ 47965567 | JNJ 47965567. Group: Biochemicals. Grades: Highly Purified. CAS No. 1428327-31-4. Pack Sizes: 10mg. Molecular Formula: C28H32N4O2S, Molecular Weight: 488.64. US Biological Life Sciences. | Worldwide |
| JNJ 5207787 | JNJ 5207787 has been found to be a selective NPY Y2 antagonist (IC50 = 0.1 μM). Synonyms: JNJ-5207787; JNJ 5207787; JNJ5207787; (2E)-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)-4-piperidinyl]-2-propenamide; trans-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)piperidin-4-yl]acrylamide. Grades: ≥98% by HPLC. CAS No. 683746-68-1. Molecular formula: C32H38N4O2. Mole weight: 510.67. | |
| JNJ 5207852 | JNJ 5207852. Group: Biochemicals. Alternative Names: 1-[3- (4- ( (Piperidin-1-yl) methyl) phenoxy) propyl]piperidine. Grades: Highly Purified. CAS No. 398473-34-2. Pack Sizes: 10mg. Molecular Formula: C20H32N2O, Molecular Weight: 316.48. US Biological Life Sciences. | Worldwide |
| JNJ-5207852 | JNJ-5207852 is a selective and potent histamine H 3 receptor (H 3 R) antagonist, with pK i s of 8.9, 9.24 for rat and human H 3 R, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 398473-34-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12190. | |
| JNJ 5207852 dihydrochloride | Cas No. 398473-34-2. | |
| JNJ-54717793 | JNJ-54717793 is a selective antagonist with a preference for Ox1R over Ox2R. Ox1R and Ox2R were indicated to play important roles in the control of sleep-wake, the regulation of food intake, addiction, reward, mood, panic, anxiety and stress. JNJ-54717793 disrupted REM time sleep in Ox2R knockout mice model, and attenuated panic in a CO2-induced model. Uses: Disrupt rem time sleep, attenuate panic. Synonyms: JNJ 54717793; JNJ54717793. CAS No. 1628843-99-1. Molecular formula: C22H18F4N6O. Mole weight: 458.41. | |
| JNJ 55511118 | JNJ 55511118 has been found to be an AMPA receptor modulator and could probably be used as an anticonvulsant. Synonyms: JNJ-55511118; JNJ 55511118; JNJ55511118; 5-[2-Chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro-2H-benzimidazol-2-one. Grades: ≥98% by HPLC. CAS No. 2036081-86-2. Molecular formula: C14H8ClF3N2O2. Mole weight: 328.67. | |
| JNJ-632 | JNJ-632 is a modulator of hepatitis B virus (HBV) capsid assembly. It induces the formation of morphologically intact viral capsids, as demonstrated by size exclusion chromatography and electron microscopy studies. Uses: Antiviral agents. Synonyms: N-(4-fluoro-3-methylphenyl)-3-[[(3S)-oxolan-3-yl]sulfamoyl]benzamide. Grades: ≥98%. CAS No. 1572510-42-9. Molecular formula: C18H19FN2O4S. Mole weight: 378.42. | |
| JNJ 63533054 | JNJ 63533054 is a potent and selective GPR139 agonist (EC50 = 16 nM) that is brain and cell penetrant. JNJ 63533054 is selective for GPR139 over a panel of GPCRs, ion channels and transporters, including GPR142. Synonyms: 3-chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide; GTPL8766; GTPL 8766; GTPL-8766; JNJ 63533054; JNJ63533054; JNJ-63533054. Grades: 98%. CAS No. 1802326-66-4. Molecular formula: C17H17ClN2O2. Mole weight: 316.785. | |
| JNJ 63533054 | JNJ 63533054 is a potent and selective GPR139 agonist (EC50 = 16 nM) that is brain and cell penetrant. JNJ 63533054 is selective for GPR139 over a panel of GPCRs, ion channels and transporters, including GPR142 and is orally bioavailable. Group: Agonists. Alternative Names: JNJ 63533054; JNJ63533054; JNJ-63533054. CAS No. 1802326-66-4. Molecular formula: C17H17ClN2O2. Mole weight: 316.79. Appearance: Solid powder. Purity: >98%. IUPACName: 3-Chloro-N-[2-oxo-2-[[ (1S) -1-phenylethyl]amino]ethyl]benzamide. Canonical SMILES: O=C (NCC (N[C@H] (C1=CC=CC=C1)C)=O)C2=CC=CC (Cl)=C2. Catalog: ACM1802326664. | |
| JNJ-63576253 | JNJ-63576253 (TRC-253) is a potent and orally active full antagonist of androgen receptor (AR) , with IC 50 s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 can be used for the research of castration-resistant prostate cancer (CRPC) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TRC-253. CAS No. 2110428-64-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115282A. | |
| JNJ-63576253 | JNJ63576253, also known as TRC253, is a potent and orally active androgen receptor antagonist. TRC253 specifically binds to both wild-type and certain mutant forms of AR, thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus. This prevents binding to and transcription of AR-responsive genes, inhibits the expression of genes that regulate prostate cancer cell proliferation, and may lead to an inhibition of growth of tumor cells in which AR is overexpressed and/or mutated. AR is often overexpressed and/or mutated in prostate cancers and plays a key role in proliferation, survival and chemoresistance of tumor cells. Group: Antagonists. Alternative Names: TRC253; TRC-253; TRC 253; JNJ63576253; JNJ 63576253; JNJ 63576253. CAS No. 2110426-27-0. Molecular formula: C23H21F3N6O2S. Mole weight: 502.52. Appearance: Solid powder. Purity: >98%. IUPACName: 5- (8-Oxo-5- (6- (piperidin-4-yloxy)pyridin-3-yl)-6-thioxo-5, 7-diazaspiro[3. 4]octan-7-yl)-3- (trifluoromethyl)-picolinonitrile. Canonical SMILES: N#CC1=NC=C (N (C2=O)C (N (C3=CC=C (OC4CCNCC4)N=C3)C52CCC5)=S)C=C1C (F) (F)F. Catalog: ACM2110426270. | |
| JNJ-64264681 | JNJ-64264681 is a potent, orally active, selective and irreversible covalent BTK inhibitor. JNJ-64264681 exhibits good pharmacokinetic characteristics and can be used for cancer and autoimmune diseases research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2101524-34-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153245. | |
| JNJ-64413739 | JNJ-64413739 is a potential P2X7 receptor positron emission tomography (PET) tracer, which is potent and selective of human and mice P2X7 receptor. Uses: Potential p2x7 receptor positron emission tomography (pet) tracer. Synonyms: JNJ 64413739; JNJ64413739. Molecular formula: C17H13F4N7O. Mole weight: 407.3. | |
| JNJ-64619178 | JNJ-64619178 is a selective PRMT5 inhibitor with potent in vitro and in vivo activity. JNJ-64619178 binds simultaneously to the SAM- and protein substrate- binding pockets of the PRMT5/MEP50 complex with a pseudo-irreversible mode-of-action. It can be developed as the treatment of some malignancies. Uses: Enzyme inhibitors. Synonyms: (1S,2R,3S,5R)-3-[2-(2-Amino-3-bromoquinolin-7-yl)ethyl]-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol. CAS No. 2086772-26-9. Molecular formula: C22H23BrN6O2. Mole weight: 483.36. | |
| JNJ-7706621 | JNJ-770662 is a broad spectrum inhibitor of cyclin-dependent kinases and aurora kinases including CDK1/Cyclin B, CDK2/Cyclin A, CDK2/Cyclin E, Aurora-A and Aurora-B. JNJ-770662 has been shown to induce growth suppression and mitotic defects, these results suggest that JNJ-7706621 could be useful for cell cycle analysis and therapy of various cancers, including Ewing's sarcoma. Group: Biochemicals. Alternative Names: N3-[4-(Aminosulfonyl)phenyl]-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazole-3,5-diamine; 4- [ [5-Amino-1- (2, 6-difluorobenzoyl) -1H- [1, 2, 4] triazol-3-yl] amino] benzenesulfonamide; JNJ 770662. Grades: Highly Purified. CAS No. 443797-96-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
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