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| Product | Description | |
|---|---|---|
| JNJ 28871063 hydrochloride | The hydrochloride salt form of JNJ 28871063, which has been found to be a nonquinazoline Pan-ErbB kinase inhibitor and probably could restrain the growth of human tumor xenografts. Synonyms: JNJ28871063 hydrochloride; JNJ-28871063 hydrochloride; 5E-4-Amino-6-(4-benzyloxy-3-chlorophenylamino)pyrimidine-5-carboxaldehyde N-(2-morpholin-4-ylethyl) oxime hydrochloride; 5-Pyrimidinecarboxaldehyde, 4-amino-6-[[3-chloro-4-(phenylmethoxy)phenyl]amino]-, O-[2-(4-morpholinyl)ethyl]oxime, hydrochloride (1:1), [C(E)]-; JNJ 28871063; (E)-4-amino-6-((4-(benzyloxy)-3-chlorophenyl)amino)pyrimidine-5-carbaldehyde O-(2-morpholinoethyl) oxime hydrochloride. Grades: ≥97% by HPLC. CAS No. 944342-90-9. Molecular formula: C24H27ClN6O3.HCl. Mole weight: 519.42. |  |
| JNJ 28871063 hydrochloride | JNJ 28871063 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 944342-90-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| JNJ 303 | JNJ 303 has been found to be a potent IKs blocker (IC50 = 64 nM) as well as a 11β-HSD1 inhibitor. Synonyms: JNJ303; JNJ-303; JNJ 303; AC-1; AC 1; AC1; 2-(4-Chlorophenoxy)-2-methyl-N-[5-[(methylsulfonyl)amino]tricyclo[3. 3. 1. 13, 7]dec-2-yl]-propanamide. Grades: ≥98% by HPLC. CAS No. 878489-28-2. Molecular formula: C21H29ClN2O4S. Mole weight: 440.98. | |
| JNJ-31020028 | JNJ-31020028 is a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptor. JNJ-31020028 bound with high affinity (IC50 = 8.07, human) and was 100-fold selective versus human Y(1), Y(4), and Y(5) receptors. JNJ-31020028 was demonstrated to be an antagonist (pK(B) = 8.04) in functional assays. Synonyms: JNJ31020028; JNJ 31020028; JNJ-31020028. Grades: 98%. CAS No. 1094873-14-9. Molecular formula: C34H36FN5O2. Mole weight: 565.6. | |
| JNJ-37822681 dihydrochloride | JNJ-37822681 dihydrochloride is a potent, specific, centrally active and fast-dissociating antagonist of dopamine D2 receptor with a moderate binding affinity to dopamine D2L receptor (Ki = 158 nM). It has the potential to treat schizophrenia and bipolar disorder. Synonyms: 3-Pyridazinamine, N-(1-((3,4-difluorophenyl)methyl)-4-piperidinyl)-6-(trifluoromethyl)-, hydrochloride (1:2); N-(1-(3,4-difluorobenzyl)piperidin-4-yl)-6-(trifluoromethyl)pyridazin-3-amine dihydrochloride; N-[1-(3,4-Difluorobenzyl)-4-piperidinyl]-6-(trifluoromethyl)-3-pyridazinamine dihydrochloride. Grades: ≥98%. CAS No. 2108806-02-4. Molecular formula: C17H19Cl2F5N4. Mole weight: 445.26. | |
| JNJ-37822681 dihydrochloride | JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D 2 receptor antagonist with a moderate binding affinity for the dopamine D 2L receptor ( K i =158 nM), which has potential for the treatment of schizophrenia and bipolar disorder [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2108806-02-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111066A. |  |
| JNJ-38877605 | JNJ-38877605 is an orally active ATP-competitive inhibitor of c-Met with an IC 50 of 4 nM, 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases [1] [2]. JNJ-38877605 inhibits c-Met phosphorylation and regulates lipid accumulation. JNJ-38877605 can be used for tumor and metabolic disease reseach [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 943540-75-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50683. | |
| JNJ-38877605 | JNJ-38877605 is an ATP-competitive inhibitor of c-Met with IC50 of 4 nM, 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases. Synonyms: JNJ-38877605; JNJ 38877605; JNJ38877605. Grades: >98%. CAS No. 943540-75-8. Molecular formula: C19H13F2N7. Mole weight: 377.36. | |
| JNJ-38877618 | JNJ-38877618 is a potent and selective inhibitor of hepatocyte growth factor receptor (HGFR; MET) that exhibits inhibitory effects against solid tumors. Synonyms: OMO-1; HY-111050; 6-[Difluoro-(6-pyridin-4-yl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl]quinoline. CAS No. 943540-74-7. Molecular formula: C20H12F2N6. Mole weight: 374.35. | |
| JNJ-39327041 | JNJ-39327041 is a bio-active chemical compound. Synonyms: JNJ-39327041; JNJ 39327041; JNJ39327041. N-[(4R)-4-(3,4-dimethoxyphenyl)-4-[7-(4-ethylpiperazin-1-yl)-3-oxo-1H-isoindol-2-yl]butyl]-1,2-dimethylimidazole-4-sulfonamide;JNJ39327041;1H-Imidazole-4-sulfonamide, N-((4R)-4-(3,4-dimethoxyphenyl)-4-(4-(4-ethyl-1-piperazinyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl)butyl)-1,2-dimethyl-. Grades: 95%. CAS No. 1093069-32-9. Molecular formula: C31H42N6O5S. Mole weight: 610.77. | |
| JNJ-39758979 dihydrochloride | JNJ-39758979 is a potent and selective histamine H4 antagonist (Ki = 12.5 nM) with >80-fold selectivity for H4 over other histamine receptors. It was shown to inhibit histamine-induced pruritus in healthy subjects. Synonyms: 4-[(3R)-3-Amino-1-pyrrolidinyl]-6-(1-methylethyl)-2-pyridinamine dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1620648-30-7. Molecular formula: C11H19N5·2HCl. Mole weight: 294.22. | |
| JNJ-39933673 hemihydrate | TA-1887 is a selective Sodium Glucose Cotransporter 2 Inhibitor with pronounced antihyperglycemic effects in high-fat diet-fed KK (HF-KK) mice. It may be used for treatment of Type 2 Diabetes in the future. Uses: Type 2 diabetes. Synonyms: JNJ-39933673 hemihydrate; TA-1887 hemihydrate; JNJ 39933673 hemihydrate; TA 1887 hemihydrate; JNJ39933673 hemihydrate; TA1887 hemihydrate; (2R,3R,4S,5S,6R)-2-(3-(4-cyclopropylbenzyl)-4-fluoro-1H-indol-1-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol hemihydrate;1003005-29-5(Free). Grades: 98%. CAS No. 1404307-42-1. Molecular formula: 2(C24H26FNO5).H2O. Mole weight: 872.95. | |
| JNJ-40355003 | JNJ-40355003 is a selective fatty acid amide hydrolase (FAAH) inhibitor. JNJ-40355003 can elevate the plasma levels of anandamide, oleoyl ethanolamide, and palmitoyl ethanolamide in animal model. Synonyms: JNJ-40355003; JNJ 40355003; JNJ40355003; 4-((3-(4-chlorophenoxy)phenyl)methyl)-N-3-pyridinyl-1-Piperazinecarboxamide. Grades: 98%. CAS No. 1394894-41-7. Molecular formula: C23H23ClN4O2. Mole weight: 422.91. | |
| JNJ-40411813 | JNJ-40411813, also known as ADX71149, is a positive allosteric modulator of the mGlu2 receptor. JNJ-40411813 acts as a PAM at the cloned mGlu2 receptor: EC50=147 ± 42 nmol/L in a [(35)S]GTPγS binding assay with human metabotropic glutamate type 2 (hmGlu2) CHO cells and EC50=64 ± 29 nmol/L in a Ca(2+) mobilization assay with hmGlu2 G α16 cotransfected HEK293 cells. JNJ-40411813 displaced [(3)H]JNJ-40068782 and [(3)H]JNJ-46281222 (mGlu2 receptor PAMs), while it failed to displace [(3)H]LY341495 (a competitive mGlu2/3 receptor antagonist). JNJ-40411813 is an interesting candidate to explore the therapeutic potential of mGlu2 PAMs, in in vivo rodents experiments as well as in clinical studies. Uses: Designed for use in research and industrial production. Additional or Alternative Names: JNJ-40411813; JNJ 40411813; JNJ40411813; ADX71149; ADX 71149; ADX-71149. Product Category: Others. Appearance: Solid powder. CAS No. 1127498-03-6. Molecular formula: C20H25ClN2O. Mole weight: 344.88. Purity: >98%. IUPACName: 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone. Canonical SMILES: ClC1=C(N2CCC(C3=CC=CC=C3)CC2)C=CN(CCCC)C1=O. Product ID: ACM1127498036. Alfa Chemistry ISO 9001:2015 Certified. |  |
| JNJ-40411813 | JNJ-40411813 is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM. Synonyms: JNJ-40411813; JNJ 40411813; JNJ40411813; ADX71149; ADX 71149; ADX-71149. Grades: >98%. CAS No. 1127498-03-6. Molecular formula: C20H25ClN2O. Mole weight: 344.88. | |
| JNJ-40418677 | JNJ-40418677 is an orally active modulator of γ-secretase , can cross the blood-brain barrier. JNJ-40418677 inhibits Aβ42 and NS2B-NS3 protease , with IC 50 s of 200 nM and 3.9 μM, respectively. JNJ-40418677 displays good biological tolerance, can be use for Alzheimers disease research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1146594-87-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100604. | |
| JNJ-40418677 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| JNJ-41443532 | JNJ-41443532 (CCR2 antagonist 5) is a selective, orally active hCCR2 inhibitor with good binding affinity ( IC 50 =37 nM) and potent functional antagonism ( chemotaxis IC 50 =30 nM). JNJ-41443532 displays a K i of 9.6 μM for mCCR2 binding. JNJ-41443532 can be used in the research of inflammatory disease [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CCR2 antagonist 5. CAS No. 1228650-83-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13499. | |
| JNJ-41443532 | This active molecular is a CCR2 receptor antagonist which is applicated for the treatment of type-2 diabetes mellitus under the development of Janssen Research & Development. In 2010, Phase-I clinical trials in Type-2 diabetes mellitus was on-going. in Belgium and USA. Uses: Type-2 diabetes mellitus. Synonyms: JNJ-41443532; JNJ 41443532; JNJ41443532; JNJ-41443532 Free Base; N-(2-((1-(trans-4-hydroxy-4-(5-thiazolyl)cyclohexyl)-3-azetidinyl)amino)-2-oxoethyl)-3-(trifluoromethyl)Benzamide. Grades: 98%. CAS No. 1228650-83-6. Molecular formula: C22H25F3N4O3S. Mole weight: 482.52. | |
| JNJ-42041935 | JNJ-42041935 is a potent, competitive and selective inhibitor of prolyl hydroxylase PHD ; inhibits PHD1, PHD2, and PHD3 with pK i values of 7.91±0.04, 7.29 ±0.05, and 7.65±0.09, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1193383-09-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12832. | |
| JNJ-42041935 | JNJ-42041935 is a potent (pK(I) = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes. JNJ-42041935 is a new pharmacological tool, which can investigate PHD inhibition and demonstrate that PHD inhibitors offer great promise for the treatment of inflammation-induced anemia. Synonyms: JNJ-42041935; JNJ 42041935; JNJ42041935. Grades: 98%. CAS No. 1193383-09-3. Molecular formula: C12H6ClF3N4O3. Mole weight: 346.65. | |
| JNJ-42153605 | JNJ-42153605 is a selective positive allosteric modulator of the metabotropic glutamate 2 (mGlu2) receptor (EC50 = 17 Nm) with an acceptable pharmacokinetic profile in rodent and nonrodent species. Synonyms: 3-(cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine; 3-cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl(1,2,4)triazolo(4,3-a)pyridine; JNJ-42153605; JNJ 42153605; JNJ42153605. CAS No. 1254977-87-1. Molecular formula: C22H23F3N4. Mole weight: 400.44. | |
| JNJ-42165279 | JNJ-42165279 is a fatty acid amide hydrolase (FAAH) inhibitor developed by Janssen Pharmaceutica and IC50 value is 70 nM. It is described as a covalently binding but slowly reversible selective inhibitor of FAAH. Phase II human trials for the treatment of anxiety disorders and major depressive disorder is on-going. Uses: Anxiety disorders and major depressive disorder. Synonyms: N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methyl)piperazine-1-carboxamide; JNJ-42165279; JNJ 42165279; JNJ42165279. Grades: 98%. CAS No. 1346528-50-4. Molecular formula: C18H17ClF2N4O3. Mole weight: 410.81. | |
| JNJ-42165279 | JNJ-42165279 is an orally active FAAH inhibitor, with IC 50 values of 70 nM for hFAAH and 313 nM for rFAAH. JNJ-42165279 can be used in research related to the field of neuropathic pain [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1346528-50-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19636. | |
| JNJ-42165279 hydrochloride | JNJ-42165279 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor. JNJ-42165279 covalently inactivates the FAAH enzyme, but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. Synonyms: JNJ-42165279 hydrochloride; JNJ 42165279 hydrochloride; JNJ42165279 hydrochloride; 1-Piperazinecarboxamid?e, N-(4-chloro-3-pyridinyl)?-4-[(2,?2-difluoro-1,?3-benzodioxol-5-yl)?methyl]?-, hydrochloride (1:1). CAS No. 1346528-52-6. Molecular formula: C18H17ClF2N4O3. HCl. Mole weight: 447.3. | |
| JNJ-42259152 | This molecular is a phosphodiesterase 10A PET tracer. Related studies show that PDE10A activity can be reliably quantified and simplified using a reference tissue model with the frontal cortex as reference and a 60-min acquisition period. Uses: Phosphodiesterase 10a pet tracer. Synonyms: JNJ-42259152; JNJ 42259152; JNJ42259152. UNII-B1QHA9M0I6;2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)-3,5-dimethylpyridine. Grades: 98%. CAS No. 1301167-87-2. Molecular formula: C24H23FN4O. Mole weight: 402.46. | |
| JNJ 42396302 | JNJ 42396302 is an Antipsychotics originated by Janssen-Cilag. But no development has been reported yet. Uses: Antipsychotics. Synonyms: JNJ 42396302; JNJ42396302; JNJ-42396302. UNII-P5M4972608;3-(6-(2-methoxyethyl)-3-pyridinyl)-2-methyl-8-(4-morpholinyl)-Imidazo(1,2-b)pyridazine. Grades: 98%. CAS No. 1298030-18-8. Molecular formula: C19H23N5O2. Mole weight: 352.43. | |
| JNJ4796 | JNJ4796 is an oral active influenza virus fusion inhibitor. Synonyms: EZ7; JNJ-4796; JNJ 4796. Grades: 98%. CAS No. 2241664-16-2. Molecular formula: C28H27N9O3. Mole weight: 537.6. | |
| JNJ 47965567 | JNJ 47965567 has been found to be a selective P2X7 antagonist and is brain penetrant. Synonyms: JNJ-47965567; JNJ 47965567; JNJ47965567. 2-(Phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl-3-pyridinecarboxamide. Grades: ≥98% by HPLC. CAS No. 1428327-31-4. Molecular formula: C28H32N4O2S. Mole weight: 488.64. | |
| JNJ 47965567 | JNJ 47965567. Group: Biochemicals. Grades: Highly Purified. CAS No. 1428327-31-4. Pack Sizes: 10mg. Molecular Formula: C28H32N4O2S, Molecular Weight: 488.64. US Biological Life Sciences. | Worldwide |
| JNJ-47965567 | JNJ-47965567 is a centrally permeable, high-affinity, selective P2X7 antagonist, with pKis of 7.9 and 8.7 for human and rat P2X7, respectively. JNJ-47965567 can be used to probe the role of central P2X7 in rodent models of CNS pathophysiology[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1428327-31-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101418. | |
| JNJ-47965567 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| JNJ-49095397 | JNJ-49095397 (RV568) is an inhaled narrow-spectrum kinase inhibitor (NSKI) against both the ? and ? isoforms of p38 MAPK. JNJ-49095397 also inhibits SRC kinase family, specifically haematopoietic kinase (HCK) JNJ-49095397 shows potent anti-inflammatory effects and can be used for the research of chronic obstructive pulmonary disease (COPD) and asthma[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RV568. CAS No. 1220626-82-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120595. | |
| JNJ 5207787 | JNJ 5207787 has been found to be a selective NPY Y2 antagonist (IC50 = 0.1 μM). Synonyms: JNJ-5207787; JNJ 5207787; JNJ5207787; (2E)-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)-4-piperidinyl]-2-propenamide; trans-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)piperidin-4-yl]acrylamide. Grades: ≥98% by HPLC. CAS No. 683746-68-1. Molecular formula: C32H38N4O2. Mole weight: 510.67. | |
| JNJ 5207852 | JNJ 5207852. Group: Biochemicals. Alternative Names: 1-[3- (4- ( (Piperidin-1-yl) methyl) phenoxy) propyl]piperidine. Grades: Highly Purified. CAS No. 398473-34-2. Pack Sizes: 10mg. Molecular Formula: C20H32N2O, Molecular Weight: 316.48. US Biological Life Sciences. | Worldwide |
| JNJ-5207852 | JNJ-5207852 is a selective and potent histamine H 3 receptor (H 3 R) antagonist, with pK i s of 8.9, 9.24 for rat and human H 3 R, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 398473-34-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12190. | |
| JNJ 5207852 dihydrochloride | Cas No. 398473-34-2. | |
| JNJ-54717793 | JNJ-54717793 is a selective antagonist with a preference for Ox1R over Ox2R. Ox1R and Ox2R were indicated to play important roles in the control of sleep-wake, the regulation of food intake, addiction, reward, mood, panic, anxiety and stress. JNJ-54717793 disrupted REM time sleep in Ox2R knockout mice model, and attenuated panic in a CO2-induced model. Uses: Disrupt rem time sleep, attenuate panic. Synonyms: JNJ 54717793; JNJ54717793. CAS No. 1628843-99-1. Molecular formula: C22H18F4N6O. Mole weight: 458.41. | |
| JNJ-55308942 | JNJ-55308942 is a high-affinity, selective, brain-penetrant P2X7 functional antagonist (hP2X7: IC50=10 nM, Ki=7.1 nM; rP2X7: IC50=15 nM, Ki=2.9 nM). JNJ-55308942 is orally bioavailable, binds to brain P2X7 and blocks IL-1? release from adult rodent brain[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2166558-11-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123857. | |
| JNJ 55511118 | JNJ 55511118 has been found to be an AMPA receptor modulator and could probably be used as an anticonvulsant. Synonyms: JNJ-55511118; JNJ 55511118; JNJ55511118; 5-[2-Chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro-2H-benzimidazol-2-one. Grades: ≥98% by HPLC. CAS No. 2036081-86-2. Molecular formula: C14H8ClF3N2O2. Mole weight: 328.67. | |
| JNJ-55511118 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| JNJ-632 | JNJ-632 is a modulator of hepatitis B virus (HBV) capsid assembly. It induces the formation of morphologically intact viral capsids, as demonstrated by size exclusion chromatography and electron microscopy studies. Uses: Antiviral agents. Synonyms: N-(4-fluoro-3-methylphenyl)-3-[[(3S)-oxolan-3-yl]sulfamoyl]benzamide. Grades: ≥98%. CAS No. 1572510-42-9. Molecular formula: C18H19FN2O4S. Mole weight: 378.42. | |
| JNJ 63533054 | JNJ 63533054 is a potent and selective GPR139 agonist (EC50 = 16 nM) that is brain and cell penetrant. JNJ 63533054 is selective for GPR139 over a panel of GPCRs, ion channels and transporters, including GPR142 and is orally bioavailable. Uses: Designed for use in research and industrial production. Additional or Alternative Names: JNJ 63533054; JNJ63533054; JNJ-63533054. Product Category: Agonists. Appearance: Solid powder. CAS No. 1802326-66-4. Molecular formula: C17H17ClN2O2. Mole weight: 316.79. Purity: >98%. IUPACName: 3-Chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide. Canonical SMILES: O=C(NCC(N[C@H](C1=CC=CC=C1)C)=O)C2=CC=CC(Cl)=C2. Product ID: ACM1802326664. Alfa Chemistry ISO 9001:2015 Certified. | |
| JNJ 63533054 | JNJ 63533054 is a potent and selective GPR139 agonist (EC50 = 16 nM) that is brain and cell penetrant. JNJ 63533054 is selective for GPR139 over a panel of GPCRs, ion channels and transporters, including GPR142. Synonyms: 3-chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide; GTPL8766; GTPL 8766; GTPL-8766; JNJ 63533054; JNJ63533054; JNJ-63533054. Grades: 98%. CAS No. 1802326-66-4. Molecular formula: C17H17ClN2O2. Mole weight: 316.785. | |
| JNJ-63533054 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| JNJ-63576253 | JNJ-63576253 (TRC-253) is a potent and orally active full antagonist of androgen receptor (AR) , with IC 50 s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 can be used for the research of castration-resistant prostate cancer (CRPC) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TRC-253. CAS No. 2110428-64-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115282A. | |
| JNJ-63576253 | JNJ63576253, also known as TRC253, is a potent and orally active androgen receptor antagonist. TRC253 specifically binds to both wild-type and certain mutant forms of AR, thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus. This prevents binding to and transcription of AR-responsive genes, inhibits the expression of genes that regulate prostate cancer cell proliferation, and may lead to an inhibition of growth of tumor cells in which AR is overexpressed and/or mutated. AR is often overexpressed and/or mutated in prostate cancers and plays a key role in proliferation, survival and chemoresistance of tumor cells. Uses: Designed for use in research and industrial production. Additional or Alternative Names: TRC253; TRC-253; TRC 253; JNJ63576253; JNJ 63576253; JNJ 63576253. Product Category: Antagonists. Appearance: Solid powder. CAS No. 2110426-27-0. Molecular formula: C23H21F3N6O2S. Mole weight: 502.52. Purity: >98%. IUPACName: 5-(8-Oxo-5-(6-(piperidin-4-yloxy)pyridin-3-yl)-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)-picolinonitrile. Canonical SMILES: N#CC1=NC=C(N(C2=O)C(N(C3=CC=C(OC4CCNCC4)N=C3)C52CCC5)=S)C=C1C(F)(F)F. Product ID: ACM2110426270. Alfa Chemistry ISO 9001:2015 Certified. | |
| JNJ-64264681 | JNJ-64264681 is a potent, orally active, selective and irreversible covalent BTK inhibitor. JNJ-64264681 exhibits good pharmacokinetic characteristics and can be used for cancer and autoimmune diseases research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2101524-34-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153245. | |
| JNJ-64413739 | JNJ-64413739 is a potential P2X7 receptor positron emission tomography (PET) tracer, which is potent and selective of human and mice P2X7 receptor. Uses: Potential p2x7 receptor positron emission tomography (pet) tracer. Synonyms: JNJ 64413739; JNJ64413739. Molecular formula: C17H13F4N7O. Mole weight: 407.3. | |
| JNJ-64619178 | JNJ-64619178 is a selective PRMT5 inhibitor with potent in vitro and in vivo activity. JNJ-64619178 binds simultaneously to the SAM- and protein substrate- binding pockets of the PRMT5/MEP50 complex with a pseudo-irreversible mode-of-action. It can be developed as the treatment of some malignancies. Uses: Enzyme inhibitors. Synonyms: (1S,2R,3S,5R)-3-[2-(2-Amino-3-bromoquinolin-7-yl)ethyl]-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol. CAS No. 2086772-26-9. Molecular formula: C22H23BrN6O2. Mole weight: 483.36. | |
| JNJ-7706621 | JNJ-7706621 is a novel cell cycle inhibitor that showed potent inhibition of several cyclin-dependent kinases (CDK) and Aurora kinases and selectively blocked proliferation of tumor cells of various origins but was about 10-fold less effective at inhibiting normal human cell growth in vitro. In human cancer cells, treatment with JNJ-7706621 inhibited cell growth independent of p53, retinoblastoma, or P-glycoprotein status; activated apoptosis; and reduced colony formation. At low concentrations, JNJ-7706621 slowed the growth of cells and at higher concentrations induced cytotoxicity. Synonyms: JNJ-7706621; JNJ-7706621; JNJ-7706621. CAS No. 443797-96-4. Molecular formula: C15H12F2N6O3S. Mole weight: 394.36. | |
| JNJ-7706621 | JNJ-770662 is a broad spectrum inhibitor of cyclin-dependent kinases and aurora kinases including CDK1/Cyclin B, CDK2/Cyclin A, CDK2/Cyclin E, Aurora-A and Aurora-B. JNJ-770662 has been shown to induce growth suppression and mitotic defects, these results suggest that JNJ-7706621 could be useful for cell cycle analysis and therapy of various cancers, including Ewing's sarcoma. Group: Biochemicals. Alternative Names: N3-[4-(Aminosulfonyl)phenyl]-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazole-3,5-diamine; 4- [ [5-Amino-1- (2, 6-difluorobenzoyl) -1H- [1, 2, 4] triazol-3-yl] amino] benzenesulfonamide; JNJ 770662. Grades: Highly Purified. CAS No. 443797-96-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| JNJ-7706621 | JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2, with IC50s of 9 nM, 3 nM, 11 nM, and 15 nM for CDK1, CDK2, aurora-A and aurora-B, respectively[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 443797-96-4. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10329. | |
| JNJ7777120 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| JNJ-7777120 | JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM, exhibits >1000-fold selectivity over the other histamin receptors. Synonyms: JNJ7777120; JNJ-7777120; JNJ 7777120. Grades: >98%. CAS No. 459168-41-3. Molecular formula: C14H16ClN3O. Mole weight: 277.75. | |
| JNJ-7777120 | JNJ-7777120 is a potent and selective histamine H 4 receptor antagonist ( K i =4.5 nM). JNJ-7777120 effectively blocks histamine-induced migration of mouse tracheal mast cells from connective tissue to epithelial cells. JNJ-7777120 also significantly blocks neutrophil infiltration in a mouse Zymosan-induced peritonitis model. JNJ-7777120 has a good potential to study antipruritic and anti-inflammatory [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 459168-41-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13508. | |
| JNJ7925476 HCl | JNJ7925476 HCl is a novel triple monoamine uptake inhibitor. It blocks the serotonin transporter (SERT), norepinephrine transporter (NET) and dopamine transporter (DAT) in the central nervous system. Its ED50 values for SERT, NET, and DATwere 0.18, 0.09 and 2.4 mg/kg, respectively in rat brain. It is used as a TRI antidepressant. It was under the development by Johnson & Johnson. Uses: Jnj7925476 hcl is used as a tri antidepressant. Synonyms: JNJ-7925476; JNJ 7925476; JNJ7925476; JNJ-7925476 HCl. Pyrrolo(2,1-a)isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, hydrochloride (1:1), (6R,10bS)-rel-;Pyrrolo(2,1-a)isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, hydrochloride, trans-;JNJ-7925476 HCl;(6S,10bR)-6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline hydrochloride. Grades: >98%. CAS No. 109085-56-5. Molecular formula: C20H20ClN. Mole weight: 309.84. | |
| JNJ DGAT2-A | JNJ DGAT2-A has been found to be a DGAT2 inhibitor (IC50 = 140 nM) and also a useful intermediate. Synonyms: JNJ-DGAT2-A; JNJDGAT2A; JNJ DGAT2 A; 3-Bromo-4-[2-fluoro-4-[[4-oxo-2-[[2- (pyridin-2-yl) ethyl]amino]-1, 3-thiazol-5- (4H) ylidene]methyl]phenoxy]benzonitrile. Grades: ≥98% by HPLC. CAS No. 1962931-71-0. Molecular formula: C24H16BrFN4O2S. Mole weight: 523.38. | |
| JNJ-DGAT2-A | JNJ-DGAT2-A is a selective diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 value of 0.14 ?M in human DGAT2-expressing Sf9 insect cell membranes. JNJ-DGAT2-A can be used for the research of triglyceride (TG) synthesis[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1962931-71-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110381. | |
| JNK1, active, GST tagged from mouse | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| JNK2, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| JNK3, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| JNK3 Inhibitor XII, SR-3576 - CAS 1164153-22-3 | The JNK3 Inhibitor XII, SR-3576, also referenced under CAS 1164153-22-3, controls the biological activity of JNK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| JNK-IN-7 | Covalent modification of IRAK1 by JNK-IN-7 is a possibility and subsequent biochemical kinase assay revealed anIC50 of ~10 nM against IRAK1. JNK-IN-7 exhibited binding inhibition of 95% or more to approximately 14 kinases at the concentration of 1.0 μM. JNK-IN-7 was next tested for its ability to inhibit the enzymatic activity of a panel of 121 kinases at a concentration of 1.0 μM. Synonyms: JNK-IN-7; JNK inhibitor;JNKIN7; JNK IN 7; JNK-IN-7. Grades: >98%. CAS No. 1408064-71-0. Molecular formula: C28H27N7O2. Mole weight: 493.56. | |
| JNK-IN-7 | JNK-IN-7 is a potent JNK inhibitor with IC50 of 1.5, 2 and 0.7 nM for JNK1, JNK2 and JNK3, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: JNK inhibitor. CAS No. 1408064-71-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15617. | |
| JNK-IN-8 | JNK-IN-8 inhibits c-Jun phosphorylation in HeLa and A375 cells with EC50 of 486 nM and 338 nM, respectively. Uses: Protein kinase inhibitors. Synonyms: JNK-IN-8; JNK-IN 8; JNK-IN8; JNK Inhibitor XVI; c-Jun N-terminal Kinase Inhibitor XVI. Grades: >98%. CAS No. 1410880-22-6. Molecular formula: C29H29N7O2. Mole weight: 507.59. | |
| JNK-IN-8 | ?96% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| JNK-IN-8 | JNK-IN-8 (JNK Inhibitor XVI) is a potent JNK inhibitor with IC50s of 4.7 nM, 18.7 nM, and 1 nM for JNK1, JNK2, and JNK3, respectively[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: JNK Inhibitor XVI. CAS No. 1410880-22-6. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13319. | |
| JNK Inhibitor II (Anthra[1,9-cd]pyrazol-6(2H)-one, 1,9-pyrazoloanthrone, SP600125, SAPK Inhibitor II) | A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50=40nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-y, TNF-a, and COX-2 in cells. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription. Group: Biochemicals. Grades: Highly Purified. CAS No. 129-56-6. Pack Sizes: 5mg, 25mg, 50mg. Molecular Formula: C14H8N2O, Molecular Weight: 220.2. US Biological Life Sciences. | Worldwide |
| JNK Inhibitor II - CAS 129-56-6 | JNK Inhibitor II. SP600125, CAS 129-56-6, is a potent, cell-permeable, selective, and ATP competitive inhibitor of c-Jun N-terminal kinase (JNK; IC?? = 40 nM for JNK-1 & JNK-2 & 90 nM for JNK-3). Group: Fluorescence/luminescence spectroscopy. | |
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