A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the suppliers website for prices or more information.
| Product | Description | |
|---|---|---|
| JNJ-7706621 | JNJ-7706621 is a novel cell cycle inhibitor that showed potent inhibition of several cyclin-dependent kinases (CDK) and Aurora kinases and selectively blocked proliferation of tumor cells of various origins but was about 10-fold less effective at inhibiting normal human cell growth in vitro. In human cancer cells, treatment with JNJ-7706621 inhibited cell growth independent of p53, retinoblastoma, or P-glycoprotein status; activated apoptosis; and reduced colony formation. At low concentrations, JNJ-7706621 slowed the growth of cells and at higher concentrations induced cytotoxicity. Synonyms: JNJ-7706621; JNJ-7706621; JNJ-7706621. CAS No. 443797-96-4. Molecular formula: C15H12F2N6O3S. Mole weight: 394.36. |  |
| JNJ-7777120 | JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM, exhibits >1000-fold selectivity over the other histamin receptors. Synonyms: JNJ7777120; JNJ-7777120; JNJ 7777120. Grades: >98%. CAS No. 459168-41-3. Molecular formula: C14H16ClN3O. Mole weight: 277.75. | |
| JNJ-7777120 | JNJ-7777120 is a potent and selective histamine H 4 receptor antagonist ( K i =4.5 nM). JNJ-7777120 effectively blocks histamine-induced migration of mouse tracheal mast cells from connective tissue to epithelial cells. JNJ-7777120 also significantly blocks neutrophil infiltration in a mouse Zymosan-induced peritonitis model. JNJ-7777120 has a good potential to study antipruritic and anti-inflammatory [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 459168-41-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13508. |  |
| JNJ7925476 HCl | JNJ7925476 HCl is a novel triple monoamine uptake inhibitor. It blocks the serotonin transporter (SERT), norepinephrine transporter (NET) and dopamine transporter (DAT) in the central nervous system. Its ED50 values for SERT, NET, and DATwere 0.18, 0.09 and 2.4 mg/kg, respectively in rat brain. It is used as a TRI antidepressant. It was under the development by Johnson & Johnson. Uses: Jnj7925476 hcl is used as a tri antidepressant. Synonyms: JNJ-7925476; JNJ 7925476; JNJ7925476; JNJ-7925476 HCl. Pyrrolo(2,1-a)isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, hydrochloride (1:1), (6R,10bS)-rel-;Pyrrolo(2,1-a)isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, hydrochloride, trans-;JNJ-7925476 HCl;(6S,10bR)-6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline hydrochloride. Grades: >98%. CAS No. 109085-56-5. Molecular formula: C20H20ClN. Mole weight: 309.84. | |
| JNJ DGAT2-A | JNJ DGAT2-A has been found to be a DGAT2 inhibitor (IC50 = 140 nM) and also a useful intermediate. Synonyms: JNJ-DGAT2-A; JNJDGAT2A; JNJ DGAT2 A; 3-Bromo-4-[2-fluoro-4-[[4-oxo-2-[[2- (pyridin-2-yl) ethyl]amino]-1, 3-thiazol-5- (4H) ylidene]methyl]phenoxy]benzonitrile. Grades: ≥98% by HPLC. CAS No. 1962931-71-0. Molecular formula: C24H16BrFN4O2S. Mole weight: 523.38. | |
| JNK-IN-7 | Covalent modification of IRAK1 by JNK-IN-7 is a possibility and subsequent biochemical kinase assay revealed anIC50 of ~10 nM against IRAK1. JNK-IN-7 exhibited binding inhibition of 95% or more to approximately 14 kinases at the concentration of 1.0 μM. JNK-IN-7 was next tested for its ability to inhibit the enzymatic activity of a panel of 121 kinases at a concentration of 1.0 μM. Synonyms: JNK-IN-7; JNK inhibitor;JNKIN7; JNK IN 7; JNK-IN-7. Grades: >98%. CAS No. 1408064-71-0. Molecular formula: C28H27N7O2. Mole weight: 493.56. | |
| JNK-IN-8 | JNK-IN-8 inhibits c-Jun phosphorylation in HeLa and A375 cells with EC50 of 486 nM and 338 nM, respectively. Uses: Protein kinase inhibitors. Synonyms: JNK-IN-8; JNK-IN 8; JNK-IN8; JNK Inhibitor XVI; c-Jun N-terminal Kinase Inhibitor XVI. Grades: >98%. CAS No. 1410880-22-6. Molecular formula: C29H29N7O2. Mole weight: 507.59. | |
| JNK Inhibitor II (Anthra[1,9-cd]pyrazol-6(2H)-one, 1,9-pyrazoloanthrone, SP600125, SAPK Inhibitor II) | A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50=40nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-y, TNF-a, and COX-2 in cells. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription. Group: Biochemicals. Grades: Highly Purified. CAS No. 129-56-6. Pack Sizes: 5mg, 25mg, 50mg. Molecular Formula: C14H8N2O, Molecular Weight: 220.2. US Biological Life Sciences. |  Worldwide |
| JNK Inhibitor IX | JNK inhibitor IX is a selective and potent JNK inhibitor with pIC50 of 6.5 and 6.7 for JNK2 and JNK3, respectively. Synonyms: TCS JNK 5a, TCS-JNK-5a, JNK Inhibitor IX, SC-202671, SC 202671, SC202671. Grades: >98%. CAS No. 312917-14-9. Molecular formula: C20H16N2OS. Mole weight: 332.42. | |
| JNK Inhibitor XVI, JNK-IN-8 ( (E) -3- (4- (dimethylamino) but-2-enamido) -N- (3-methyl-4- ( (4- (pyridin-3-yl) pyrimidin-2-yl) amino) phenyl) benzamide) | A cell-permeable, selective, and irreversible type 2 inhibitor of c-Jun N-terminal kinases (JNK) (IC50=4.67nM, 18.7nM, 980pM for JNK1, JNK2, and JNK3, respectively). Forms a covalent adduct with the conserved cysteine residue (Cys116 in JNK1) and binds to JNK in an extended type 2 conformation. Blocks the phosphorylation of c-Jun in cells (EC50=486nM in HeLa cells; 338nM in A375 cells). Exhibits greater cellular specificity for JNK when compared to 40 other kinases screened using a cell-based assay. Shows weaker binding to KIT mutants (IC50=92nM for V559D and 56nM for T670I) and RIOK2 (120nM). Does not show any significant inhibitory activity against various other kinases, including ERK, p38, Akt, MSK, and RSK. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| JNK Inhibitor XV, IQ-1S (11H-Indeno[1,2-b]quinoxalin-11-one oxime, sodium salt) | A cell-permeable indenoquinoxalinone-oxime (IQ) compound that acts as a potent, non-toxic, reversible, ATP-competitive, high-affinity inhibitor of JNK (=390, 360 and 87nM for JNK1, JNK2 and JNK3, respectively) with moderate selectivity over CK1d, PI 3-Ky, and MKNK2 (IC50=1.4, 1.2, and 1.8uM, respectively). Shown to reduce c-Jun-Ser63 phosphorylation, and block the production of LPS-induced TNF-a (IC50 = 250nM) and IL-6 (IC50=610nM) in MonoMac-6 monocytic cells and in human hPBMCs, respectively. Also shown to inhibit NF-kB/AP-1 reporter activity (IC50=1.8uM) in human THP1-Blue monocytic cells and diminish nitric oxide production in murine J774-A.1 macrophages (IC50=12.5uM). Exhibits favorable pharmacokinetics properties and efficiently reduces ovalbumin-induced CD+ T-cell immune inflammation in a murine delayed-type hypersensitivity model (12.5mg/kg, two per day dosage, i.p.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H?N?Ona, Primary Target: JNK1,2,3. US Biological Life Sciences. | Worldwide |
| Jojoba Castor Beads | Tiny, spherically shaped beads consisting of natural jojoba oil and castor oil, round shape warrants effective but gentle exfoliation, not animal tested. 40/60 mesh size, white/vanilla color, ideal for exfoliation on delicate skin such as the face, lip and cuticle exfoliation. Uses: Facial scrubs, specialty bar soap, body washes, body scrubs, shower gels. Group: Sensory modifiers. CAS No. 92457-12-0/8001-78-3. Appearance: Small, round beads, faint odor. Catalog: CI-SC-0175. |  |
| Jojoba Gel | Anhydrous transparent viscous gel consisting of jojoba oil (Simmondsia chinensis) combined with polymers (ethylene-propylene-styrene copolymer & ethylene-butylene-styrene copolymer). Uses: All kinds of emulsions (creams, lotions, cleansers, hair creams, makeup foundations), lip care products, massage oils, baby oils. Group: Skin actives. CAS No. 61789-91-1/66070-58-4/68648-89-5. Appearance: Viscous pale yellow fluid, odorless. Catalog: CI-SC-0726. | |
| Jojoba Meal Extract | Extract obtained from Simmondsia Chinensis (Jojoba) seeds. Contains 20% extract dissolved in water and glycerin. Has good moisturizing and soothing properties. Widely used to for blemished, irritated or sensitive skin. Uses: Creams and lotions, bath care products. Group: Skin actives. CAS No. 7732-18-5 / 56-81-5 / 90045-98-0 / 122-99-6. Appearance: Light to medium yellow liquid, characteristic odor. Catalog: CI-SC-0903. | |
| Jojoba Oil Golden | Jojoba Oil Golden. |  CA, FL & NJ |
| Jojoba Pearls, Green | Jojoba pearls are tiny, spherically shaped beads consisting of hydrogenated natural jojoba oil (= jojoba wax), round shape warrants effective but gentle exfoliation. Ultrafine pearl size (40/60 mesh size or 250-425 microns) is ideal for exfoliation on delicate skin such as the face, lip and cuticle exfoliation. Uses: Shampoos, specialty bar soap, lotions, creams, body washes, body scrubs, shower gels. Group: Surfactants/emulsifiers. CAS No. 61789-91-1/12001-99-9. Appearance: Small, round green beads, faint odor. Catalog: CI-SC-0261. | |
| Jojoba Pearls, Orange | Jojoba pearls are tiny, spherically shaped beads consisting of hydrogenated natural jojoba oil (= jojoba wax), round shape warrants effective but gentle exfoliation. Ultrafine pearl size (40/60 mesh size or 250-425 microns) is ideal for exfoliation on delicate skin such as the face, lip and cuticle exfoliation. Uses: Shampoos, specialty bar soap, lotions, creams, body washes, body scrubs, shower gels. Group: Surfactants/emulsifiers. CAS No. 61789-91-1/2379-74-0/51274-00-1. Appearance: Small, round orange beads, faint odor. Catalog: CI-SC-0263. | |
| Jojoba Pearls, Red | Jojoba pearls are tiny, spherically shaped beads consisting of hydrogenated natural jojoba oil (= jojoba wax), round shape warrants effective but gentle exfoliation. Ultrafine pearl size (40/60 mesh size or 250-425 microns) is ideal for exfoliation on delicate skin such as the face, lip and cuticle exfoliation. Uses: Shampoos, specialty bar soap, lotions, creams, body washes, body scrubs, shower gels. Group: Surfactants/emulsifiers. CAS No. 61789-91-1/2379-74-0. Appearance: Small, round red beads, faint odor. Catalog: CI-SC-0262. | |
| Jojoba Protein HP, Hydrolyzed | Hydrolyzed (fragmented) proteins enzymatically extracted from the jojoba plant, 100% natural, MW 1800-2400 kD. Precipitations of proteins in the bottom of the container is normal. Uses: Lotions, creams, sun care products & after sun products, hair shampoos, leave-in-conditioners, hair mousse, shower gels, makeup products (mascara, foundations). Group: Skin actives. CAS No. 100684-35-3 / 7732-18-5 / 122-99-6 / 24634-61-5. Appearance: Dark brown, cloudy, faint odor. Catalog: CI-SC-0582. | |
| Jolkinolide B | Jolkinolide B. Group: Biochemicals. Grades: Plant Grade. CAS No. 37905-08-1. Pack Sizes: 10mg. Molecular Formula: C20H26O4, Molecular Weight: 330.42. US Biological Life Sciences. | Worldwide |
| Joro spider toxin(jstx-3) | Heterocyclic Organic Compound. Alternative Names: JSTX-3;JORO SPIDER TOXIN;JORO-SPIDER-TOXIN, [125I];JORO SPIDER TOXIN JSTX-3; N1- (5- (3- (3- (4-Aminobutylamino) propylamino) propanamido) pentyl) -2- (2- (2, 4-dihydroxyphenyl) acetamido) succinamide; (S) -N-[5-[[3-[[4-[ (3-Aminopropyl) amino]butyl]amino]propionyl]amino]. CAS No. 112163-33-4. Molecular formula: C27H47N7O6. Mole weight: 565.71. Appearance: Off-white lyophilized solid. Catalog: ACM112163334. | |
| Josamycin | Josamycin is a main component of YL-704, a macrolide antibiotic complex isolated from Streptomyces platensis subsp. malvinus. It is active against gram-positive bacteria. Synonyms: YL-704A3; YL 704A3; YL 704 A3; Leucomycin A3; Turimycin A5; Kitasamycin A3; Josamycine. Grades: 95%. CAS No. 16846-24-5. Molecular formula: C42H69NO15. Mole weight: 828. | |
| Josamycin | Josamycin (EN-141) is an orally active macrolide antibiotic exhibiting antimicrobial activity against a wide spectrum of pathogens, such as bacteria. The dissociation constant K d from ribosome for Josamycin is 5.5 nM [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: EN-141. CAS No. 16846-24-5. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-B1920. | |
| Josamycin | A 16-membered ring macrolide antibiotic with antimicrobial activity against a wide range of pathogens. Particularly used in the treatment of Mycoplasma infection. Alternative Names: Iosalide;Vilprafen;Leucomycin A3;EN 141. CAS No. 16846-24-5. Molecular formula: C42H69NO15. Mole weight: 827.99. Appearance: light yellow powder. Purity: 0.98. IUPACName: josamycin. Density: 1.2 g/cm³. ECNumber: 240-871-6. Catalog: ACM16846245. | |
| Josamycin 10-propionate | Josamycin 10-propionate. Uses: For analytical and research use. Group: Impurity standards. CAS No. 83310-75-2. Molecular Formula: C45H73NO16. Mole Weight: 884.07. Catalog: APB83310752. |  |
| Josamycin 5-propionate | Josamycin 5-propionate. Uses: For analytical and research use. Group: Impurity standards. CAS No. 31674-19-8. Molecular Formula: C45H73NO16. Mole Weight: 884.07. Catalog: APB31674198. | |
| Josamycin 9-propionate | Josamycin 9-propionate. Uses: For analytical and research use. Group: Impurity standards. CAS No. 40922-77-8. Molecular Formula: C45H73NO16. Mole Weight: 884.07. Catalog: APB40922778. | |
| Josamycin Deisovaleryl Impurity | Josamycin Deisovaleryl Impurity. Uses: For analytical and research use. Group: Impurity standards. CAS No. 31642-61-2. Molecular Formula: C37H61NO14. Mole Weight: 743.89. Catalog: APB31642612. | |
| Josamycin dipropionate | Josamycin dipropionate. Uses: For analytical and research use. Group: Impurity standards. CAS No. 52719-27-4. Molecular Formula: C48H77NO17. Mole Weight: 940.13. Catalog: APB52719274. | |
| Josamycin EP Impurity A | Josamycin EP Impurity A. Uses: For analytical and research use. Group: Impurity standards. CAS No. 18361-46-1. Molecular Formula: C41H67NO15. Mole Weight: 813.98. Catalog: APB18361461. | |
| Josamycin EP Impurity B | Josamycin EP Impurity B. Uses: For analytical and research use. Group: Impurity standards. CAS No. 40361-41-9. Molecular Formula: C42H71NO15. Mole Weight: 830.02. Catalog: APB40361419. | |
| Josamycin EP Impurity D | Josamycin EP Impurity D. Uses: For analytical and research use. Group: Impurity standards. CAS No. 22340-94-9. Molecular Formula: C42H69NO15. Mole Weight: 828.01. Catalog: APB22340949. | |
| Josamycin EP Impurity E | Josamycin EP Impurity E. Uses: For analytical and research use. Group: Impurity standards. CAS No. 40615-47-2. Molecular Formula: C43H71NO15. Mole Weight: 842.03. Catalog: APB40615472. | |
| Josamycin EP Impurity F | Josamycin EP Impurity F. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C35H59NO13. Mole Weight: 701.85. Catalog: APB10552. | |
| Josamycin EP Impurity G | Josamycin EP Impurity G. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C37H61NO14. Mole Weight: 743.89. Catalog: APB10553. | |
| Josamycin EP Impurity H | Josamycin EP Impurity H. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C40H67NO14. Mole Weight: 785.97. Catalog: APB10555. | |
| Josamycin EP Impurity I | Josamycin EP Impurity I. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C38H63NO14. Mole Weight: 757.92. Catalog: APB10554. | |
| Josamycin EP Impurity J | Josamycin EP Impurity J. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C43H71NO15. Mole Weight: 842.03. Catalog: APB10556. | |
| Josamycin EP Impurity K | Josamycin EP Impurity K. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C40H65NO15. Mole Weight: 799.95. Catalog: APB10557. | |
| Josamycin fosfomycin | Josamycin fosfomycin. Uses: For analytical and research use. Group: Impurity standards. CAS No. 96740-84-0. Molecular Formula: C45H76NO19P. Mole Weight: 966.06. Catalog: APB96740840. | |
| Josamycin Hydrochloride | Josamycin Hydrochloride. Uses: For analytical and research use. Group: Impurity standards. CAS No. 11033-19-5. Molecular Formula: C42H70ClNO15. Mole Weight: 864.46. Catalog: APB11033195. | |
| JP104 | JP104 is an irreversible fatty acid amide hydrolase (FAAH) inhibitor. JP104 is in the carbamate class with an IC50 of 7.3 nM for the human recombinant enzyme when tested using radiolabeled oleamide as the substrate. Synonyms: 3'-Carbamoyl-biphenyl-3-yl-undecynecarbamate. Grades: ≥98%. CAS No. 887264-45-1. Molecular formula: C25H30N2O3. Mole weight: 406.5. | |
| JP 1302 dihydrochloride | JP 1302 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1259314-65-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| JP 1302 dihydrochloride | The hydrochloride salt form of JP 1302, which has been found to be an α2-adrenoceptor blocker and could probably be used for prevention or treatment of nephropathy. Synonyms: JP 1302 dihydrochloride; JP1302 dihydrochloride; JP-1302 dihydrochloride; N-[4-(4-Methyl-1-piperazinyl)phenyl]-9-acridinamine dihydrochloride; N-[4-(4-Methyl-1-piperazinyl)phenyl]-9-acridinamine Hydrochloride (1:2). Grades: ≥99% by HPLC. CAS No. 1259314-65-2. Molecular formula: C24H24N4.2HCl. Mole weight: 441.40. | |
| JP83 | JP83 is an irreversible fatty acyl amide hydrolase (FAAH) inhibitor with an IC 50 of 1.6 nM in competitive activity-based protein profiling (ABPP) experiments [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 887264-44-0. Pack Sizes: 1 mg. Product ID: HY-111199. | |
| JP83 | JP83 is an irreversible fatty acyl amide hydrolase (FAAH) inhibitor. JP83 is in the carbamate class with an IC50 of 14 nM for the human recombinant enzyme when tested using radiolabeled oleamide as the substrate. Synonyms: 3'-Carbamoyl-biphenyl-3-yl-hexylphenylcarbamate. Grades: ≥98%. CAS No. 887264-44-0. Molecular formula: C26H28N2O3. Mole weight: 416.5. | |
| JPC-211 | JPC-211 is a selective dopamine D3 receptor agonist. Uses: Dopamine antagonists. Synonyms: JPC-211; JPC 211; JPC211; 234757-41-6(maleate); PNU-99194A free base;2,3-dihydro-5,6-dimethoxy-N,N-dipropyl- 1H-Inden-2-amine. Grades: 98%. CAS No. 82668-33-5. Molecular formula: C17H27NO2. Mole weight: 277.41. | |
| JPH203 | JPH203 Inhibitor. Uses: Scientific use. Product Category: TQ0081. CAS No. 1037592-40-7. |  |
| JPH203 | JPH203 is a potent and selective L-type amino acid transporter 1 (LAT1) inhibitor. It inhibits 14C-leucine uptake and cell growth in human colon cancer-derived HT-29 cells in vitro. It also inhibits 14C-leucine uptake in mouse renal proximal tubule cells expressing l-type amino acid transporter 1, and inhibits cell growth. It completely inhibits the proliferation of YD-38 cells in a dose- and time-dependent manner. It suppresses proliferation in cancer cell lines and is used for cancer research. It was developed by J-Pharma and in clinic phase 1 trials. Uses: Jph203 suppresses proliferation in cancer cell lines and is used for cancer research. Synonyms: KYT-0353;KYT0353;JPH-203; KYT 0353;JPH 203;(S)-2-amino-3-(4-((5-amino-2-phenylbenzo[d]oxazol-7-yl)methoxy)-3,5-dichlorophenyl)propanoic acid. Grades: >98 %. CAS No. 1037592-40-7. Molecular formula: C23H19Cl2N3O. Mole weight: 472.32. | |
| JPH203 dihydrochloride | JPH203 is a potent and selective inhibitor of L-type amino acid transporter 1 (LAT1), which is highly expressed in many tumor cells. Study has shown that JPH203 inhibited L-leucine uptake, and increased apoptosis rates and formed DNA ladder in Saos2 cells. Synonyms: KYT 0353; O-[(5-Amino-2-phenyl-7-benzoxazolyl)methyl]-3,5-dichloro-L-tyrosine dihydrochloride; (2S)-2-amino-3-[4-[(5-amino-2-phenyl-1,3-benzoxazol-7-yl)methoxy]-3,5-dichlorophenyl]propanoic acid dihydrochloride. Grades: ≥96% by HPLC. CAS No. 1597402-27-1. Molecular formula: C23H19Cl2N3O4·2HCl. Mole weight: 545.24. | |
| JQ1 | JQ1 Inhibitor. Uses: Scientific use. Product Category: T2110. CAS No. 1268524-70-4. | |
| JQ1 Enantiomers Set ((S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate, SGCBD01, BRD2 Inhibitor III, BRD3 Inhibitor II, BRD4 Inhibitor III, BRD6 Inhibitor I, BRDT Inhibitor I) | A cell-permeable I-BET class of thienodiazepine derivative whose (S)-(+), but not (R)-(-), enantiomer is shown to target both bromodomains (BD1 & BD2) of BET family members BRD2, BRD3, BRD4, and BRD6/BRDT in a Kac- (epsilon-N-acetylated lysine) competitive manner, exhibiting little affinity toward 23 other BD-containing proteins, BRD1 and BRD9, and little or no activity against a panel of more than 50 receptors, ion channels, and transporters. Effectively inhibits the oncogenic BRD4-NUT fusion-dependent NUT midline carcinoma and c-Myc oncoprotein-dependent multiple myeloma proliferation both in cultures (IC50 <1uM) in vitro and in mice (50mg/kg/day i.p.) in vivo. Also reported to cross the blood-testis boundary in male mice and effectively block BRDT-mediated spermatogenesis without affecting hormone levels. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1set. US Biological Life Sciences. | Worldwide |
| JQEZ5 | JQEZ5 is a potent and selective inhibitor of EZH2 lysine methyltransferase (IC50 = 11.1 nM). JQEZ5 is developed for the treatment of some cancers in which EZH2 is overexpressed, such as non-small cell lung carcinoma (NSCLC). Synonyms: N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1-propan-2-ylpyrazolo[3,4-b]pyridine-4-carboxamide. Grades: ≥98%. CAS No. 1913252-04-6. Molecular formula: C30H38N8O2. Mole weight: 542.68. | |
| JQKD82 HCl | JQKD82, also known as PCK82, is a cell-permeable and selective KDM5 inhibitor (MM.1S cells, IC50=0.42 uM). JQKD82 increases histone H3K4me3 but paradoxically inhibits downstream MYC-driven transcriptional output in vitro and in vivo. JQKD82 is a useful tool compound to block KDM5A function as a potential therapeutic strategy for MM. QKD82 is a more stable ester of KDM5-C49 that is able to deliver the active molecule KDM5-C49 to cells more efficiently. Group: Inhibitors. Alternative Names: JQKD82 HCl; JQKD82 hydrochloride; JQKD82; JQKD-82; JQKD 82; PCK82; PCK-82; PCK 82. CAS No. 2410512-38-6. Molecular formula: C27H43Cl3N4O5. Mole weight: 610.01. Appearance: Solid powder. Purity: >98%. IUPACName: 2,4-diisopropoxyphenyl 2- ( ( (2- ( (2- (dimethylamino) ethyl) (ethyl) amino) -2-oxoethyl) amino) methyl) isonicotinate trihydrochloride. Canonical SMILES: O=C (OC1=CC=C (OC (C)C)C=C1OC (C)C)C2=CC=NC (CNCC (N (CCN (C)C)CC)=O)=C2. [H]Cl. [H]Cl. [H]Cl. Catalog: ACM2410512386. | |
| JS11 | JS11 is an inhibitor for natriuretic polypeptide receptor 1 ( Npr1 ) with an IC 50 of 1.9 μM for hNpr1. JS11 ameliorates the pruritus in mouse models [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1394592-04-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-153650. | |
| JS25 | JS25 is a selective and covalent inhibitor of BTK that inactivates BTK with an IC 50 value of 5.8 nM by chelating Tyr551. JS25 inhibits cancer cells proliferation, pronounces cell death, and promotes murine xenograft model of Burkitts lymphoma. JS25 effectively crosses the blood-brain barrier [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2411771-95-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-151808. | |
| JS6 | JS6 is a Bcl3 inhibitor, and inhibits Bcl3-NF-kB1 binding. JS6 inhibits tumor cell growth in vitro and in vivo [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 950244-33-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-152177. | |
| JSH-150 | JSH-150 Inhibitor. Uses: Scientific use. Product Category: T8484. CAS No. 2247481-21-4. | |
| JSH-23 | JSH-23 is a nuclear factor-kappa B (NF-κB) nuclear translocation inhibitor. JSH-23 inhibits LPS and cytokine-induced nuclear translocation of the p65 subunit of NF-kB as analyzed by EMSA and western blot. JSH-23 treatment significantly reversed the nerve conduction and nerve blood flow deficits seen in diabetic animals. Reduction in mechanical pain threshold was also partially corrected by the treatment. Protein expression studies showed that nuclear translocation of p65/p50 subunit was inhibited by JSH-23 treatment in the sciatic nerve. The treatment also lowered the elevated IL-6, TNF-α, cyclo-oxygenase (COX-2) and inducible nitric oxide synthase (iNOS) levels/expression, indicating reduction in the inflammatory damage of the sciatic nerve. Apart from these effects, JSH-23 also increased Nrf2 and hemeoxygenase-1 (HO-1) levels which could imply its potential in increasing the strength of antioxidant defence. Synonyms: JSH-23; JSH 23; JSH23. Grades: 0.98. CAS No. 749886-87-1. Molecular formula: C16H20N2. Mole weight: 240.35. | |
| JT001 sodium | JT001 (NLRP3-IN-19) sodium is a potent, specific and orally active inhibitor of NLRP3. JT001 sodium can inhibit NLRP3 inflammasome assembly, resulting in the inhibition of cytokine release and the prevention of pyroptosis. JT001 sodium can be used for the research of nonalcoholic steatohepatitis and liver fibrosis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NLRP3-IN-19 sodium. CAS No. 2238820-09-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156034A. | |
| JT010 | JT010 is a TRPA1 channel activator (EC50 = 0.65 nM) with potent selectivity for TRPA1 over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 channels (EC50 values are >1 μM). It activates the TRPA1 channel by covalently and site-selectively binding to Cys621. Synonyms: 2-Chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)acetamide. Grades: ≥98% by HPLC. CAS No. 917562-33-5. Molecular formula: C16H19ClN2O3S. Mole weight: 354.85. | |
| JTC 801 | JTC 801. Group: Biochemicals. Grades: Purified. CAS No. 244218-51-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| JTC-801 | JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist with IC50 of 94 nM, weakly inhibits receptors δ, κ, and &mu. It is an opioid analgesic drug used in scientific research. Synonyms: JTC-801; JTC 801; JTC801. Grades: >98%. CAS No. 244218-51-7. Molecular formula: C26H25N3O2.HCl. Mole weight: 447.96. | |
| JTC-801 | JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist, binding to ORL1 receptor with a K i value of 8.2?nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 244218-51-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13274. | |
| JTE 013 | JTE 013. Group: Biochemicals. Grades: Purified. CAS No. 547756-93-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| JTE-013 | JTE-013 is a potent and specific S1P 2 (Sphingosine-1-Phosphate 2; EDG-5) antagonist. JTE-013 inhibits the specific binding of radiolabeled S1P to human and rat S1P 2 with IC 50 s of 17 nM and 22 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 383150-41-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-100675. | |
| JTE-013 | JTE-013 is a potent and selective sphingosine-1-phosphate (S1P) receptor 2 (S1P2) antagonist (IC50=17.6 nM). Synonyms: 1-(2,6-dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea; JTE-013; JTE 013; JTE013. Grades: >98%. CAS No. 383150-41-2. Molecular formula: C17H19Cl2N7O. Mole weight: 408.287. | |
| JTE522 | JTE522, a selective COX-2 inhibitor, can induce apoptosis and inhibit cell proliferation in human endometrial cancer cell line RL95-2 cells and to explore the molecular mechanisms. Synonyms: 4-(4-cyclohexyl-2-methyl-1,3-oxazol-5-yl)-2-fluorobenzenesulfonamide; 4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamide; JTE 522; JTE-522. CAS No. 180200-68-4. Molecular formula: C16H19FN2O3S. Mole weight: 338.4. | |
| JTE 607 dihydrochloride | The hydrochloride salt form of JTE 607, which has been found to be a cytokine release inhibitor. Synonyms: JTE 607 dihydrochloride; JTE607 dihydrochloride; JTE-607 dihydrochloride; N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride. Grades: ≥98% by HPLC. CAS No. 188791-09-5. Molecular formula: C25H31Cl2N3O5.2HCl. Mole weight: 597.36. | |
| JTE-607 HCl | JTE-607, also known as TO-207, is a cytokine production inhibitor potentially for the treatment of systemic inflammatory response, and induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells. Group: Inhibitors. Alternative Names: TO-207; TO 207; TO207; JTE-607; JTE 607; JTE 607; JTE-607 HCl; JTE-607 dihydrochloride. CAS No. 188791-09-5. Molecular formula: C25H33Cl4N3O5. Mole weight: 597.36. Appearance: Solid powder. Purity: >98%. IUPACName: N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride. Canonical SMILES: O=C (OCC)[C@H] (CC1=CC=CC=C1)NC (C2=CC (Cl)=C (OCCN3CCN (C)CC3)C (Cl)=C2O)=O. [H]Cl. [H]Cl. Catalog: ACM188791095. | |
Our database is helping our users find suppliers everyday.
