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| Product | Description | |
|---|---|---|
| JIB-04 | JIB-04 Inhibitor. Uses: Scientific use. Product Category: T1868. CAS No. 199596-05-9. |  |
| JIB-04 | JIB-04 is a potent, selective and cell-permeable inhibitor used in compound for cancer research. It targets the histone demethylase KDM5A and effectively suppresses the growth of various cancer cells like triple-negative breast cancer and acute myeloid leukemia. Synonyms: JIB04; JIB-04; JIB 04; NSC 693627; NSC-693627; NSC 693627. CAS No. 199596-05-9. Molecular formula: C17H13ClN4. Mole weight: 308.769. |  |
| JIB-04 | JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC 50 s of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 199596-05-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13953. |  |
| Jietacin A | Jietacin A is originally isolated from Str. sp. KP-197. It is found to be resistant to nematode, it can 100% kill Burs helenchus Lignicolus with the concentration of 0.25μg/mL, which is 10 times stronger than Avermectin B1a. Synonyms: Jietacine A; BRN 5538455; 1-(Ethenyl-ONN-azoxy)-14-methyl-8-pentadecanone. CAS No. 109766-61-2. Molecular formula: C18H34N2O2. Mole weight: 310.47. | |
| Jietacin B | Jietacin B is originally isolated from Str. sp. KP-197. It is found to be resistant to nematode, it can 100% kill Burs helenchus Lignicolus with the concentration of 0.25μg/mL, which is 10 times stronger than Avermectin B1a. CAS No. 109766-62-3. Molecular formula: C19H36N2O2. Mole weight: 324.50. | |
| Jindongenin-1a | Jindongenin-1a is an antibacterial peptide isolated from Amolops jingdongensis (Chinese torrent frog). It has activity against gram-positive bacteria, gram-negative bacteria and fungi. Jindongenin-1a can help to solve the serious problem of bacterial resistance to currently used antibiotics. Synonyms: Ser-Met-Gly-Ala-Val-Lys-Leu-Ala-Lys-Leu-Leu-Ile-Asp-Lys-Met-Lys-Cys-Glu-Val-Thr-Lys-Ala-Cys. Grades: 95.6%. | |
| Jingdongin-1 | Jingdongin-1 is an antibacterial peptide isolated from Amolops jingdongensis (Chinese torrent frog). It has activity against gram-positive bacteria, gram-negative bacteria and fungi. Synonyms: Phe-Leu-Pro-Leu-Phe-Leu-Pro-Lys-Ile-Ile-Cys-Val-Ile-Thr-Lys-Lys-Cys. Grades: 96.4%. Mole weight: 1976.6. | |
| Jingzhaotoxin III | Jingzhaotoxin III. Group: Biochemicals. Grades: Purified. CAS No. 925463-91-8. Pack Sizes: 100ug. US Biological Life Sciences. |  Worldwide |
| Jingzhaotoxin III | Jingzhaotoxin III is a selective blocker of NaV1.5 channels with IC50 value of 348 nM. It is selective for NaV1.5 channels and shows no effect on other isoforms. It inhibits the activation of cardiac sodium channels by binding to the NaV1.5 S3-S4 linker of domain II. It has no effect on sodium channels in dorsal root ganglion neurons. Synonyms: H-Asp-Gly-Glu-Cys(1)-Gly-Gly-Phe-Trp-Trp-Lys-Cys(2)-Gly-Arg-Gly-Lys-Pro-Pro-Cys(3)-Cys(1)-Lys-Gly-Tyr-Ala-Cys(2)-Ser-Lys-Thr-Trp-Gly-Trp-Cys(3)-Ala-Val-Glu-Ala-Pro-OH; L-alpha-aspartyl-glycyl-L-alpha-glutamyl-L-cysteinyl-glycyl-glycyl-L-phenylalanyl-L-tryptophyl-L-tryptophyl-L-lysyl-L-cysteinyl-glycyl-L-arginyl-glycyl-L-lysyl-L-prolyl-L-prolyl-L-cysteinyl-L-cysteinyl-L-lysyl-glycyl-L-tyrosyl-L-alanyl-L-cysteinyl-L-seryl-L-lysyl-L-threonyl-L-tryptophyl-glycyl-L-tryptophyl-L-cysteinyl-L-alanyl-L-valyl-L-alpha-glutamyl-L-alanyl-L-proline (4->19),(11->24),(18->31)-tris(disulfide). Grades: >98%. CAS No. 925463-91-8. Molecular formula: C174H241N47O46S6. Mole weight: 3918.44. | |
| Jionoside A1 | Jionoside A1. Group: Biochemicals. CAS No. 120444-60-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Jionoside B1 | Jionoside B1. Group: Biochemicals. Grades: Plant Grade. CAS No. 120406-37-3. Pack Sizes: 5mg. Molecular Formula: C37H50O20, Molecular Weight: 814.79. US Biological Life Sciences. | Worldwide |
| JIP-1 (153-163) | JIP-1 (153-163) has been found to be a peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (JIP-1). Synonyms: TI-JIP. Grades: >98%. CAS No. 438567-88-5. Molecular formula: C61H104N20O14. Mole weight: 1341.6. | |
| JIP-1 (153-163) acetate | JIP-1 (153-163) acetate is a c-Jun N-terminal kinase (JNK) peptide inhibitor based on JNK-interacting protein-1 (JIP-1) residues 153-163. It binds to JNK with affinity in the micromolar range and minimally inhibits p38 and ERK. Synonyms: L-Phenylalaninamide, L-arginyl-L-prolyl-L-lysyl-L-arginyl-L-prolyl-L-threonyl-L-threonyl-L-leucyl-L-asparaginyl-L-leucyl-, acetate (1:1); H-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH2.CH3CO2H; L-arginyl-L-prolyl-L-lysyl-L-arginyl-L-prolyl-L-threonyl-L-threonyl-L-leucyl-L-asparagyl-L-leucyl-L-phenylalaninamide acetate salt. Grades: ≥95%. CAS No. 1417623-78-9. Molecular formula: C61H104N20O14.C2H4O2. Mole weight: 1401.66. | |
| JJH260 | JJH260 is an inhibitor of androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). JJH260 was shown to found members of an evolutionarily conserved class of transmembrane threonine hydrolases involved in bioactive lipid metabolism. Synonyms: 7-(4-(dimethylamino)benzoyl)-1,3-dioxohexahydroimidazo[1,5-a]pyrazin-2(3H)-yl 4-(4-chlorophenethyl)piperidine-1-carboxylate. Grades: ≥90%. CAS No. 1831135-30-8. Molecular formula: C29H34ClN5O5. Mole weight: 568.1. | |
| JJKK 048 | JJKK 048 is a highly selective and potent monoacylglycerol lipase (MAGL) inhibitor with IC 50 values of 214 pM, 275 pM and 363 pM for human, rat, and mouse MAGL. JJKK 048 displays low cross-reactivity with other endocannabinoid targets. JJKK 048 can be used in the research of diseases such as cancer, neurodegenerative diseases, and pain [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1515855-97-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108613. | |
| JJKK 048 | JJKK 048. Group: Biochemicals. Grades: Purified. CAS No. 1515855-97-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| JJKK 048 | JJKK 048, a benzodioxol derivative, has been found to a MAGL inhibitor that could probably be significant in anticancer and anti-inflammatory studies. IC50: 0.4 nM. Synonyms: JJKK048; JJKK-048; JJKK 048; MolPort-035-941-193; BDBM50065646; AKOS025142062; ZINC103287208; [4-[bis(1,3-benzodioxol-5-yl)methyl]piperidin-1-yl]-(1,2,4-triazol-1-yl)methanone. Grades: 98%. CAS No. 1515855-97-6. Molecular formula: C23H22N4O5. Mole weight: 434.44. | |
| JK 184 | JK 184. Group: Biochemicals. Grades: Purified. CAS No. 315703-52-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| JK-184 | JK-184 is a potent downstream hedgehog (Hh) signaling antagonist that functions by alcohol dehydrogenase 7 (Adh7) inhibition, preventing Gli-dependent transcriptional activity (IC50 = 30 nM). Hedgehog signaling plays a key role in a wide variety of developmental processes as well as cancer progression. JK-184 exhibits antiproliferative activity. Uses: Differentiation. Synonyms: JK184; JK 184. Grades: 98%. CAS No. 315703-52-7. Molecular formula: C19H18N4OS. Mole weight: 350.44. | |
| JK 184 (N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine) | An imidazopyridine derivative that acts as a potent downstream antagonist of Hedgehog(Hh) signaling pathway. JK184 functions by inhibiting class IV alcohol dehydrogenase (Aldh7) (IC50 = 210 nM). Group: Biochemicals. Alternative Names: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine. Grades: Highly Purified. CAS No. 315703-52-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| JKC 363 | JKC 363. Group: Biochemicals. Grades: Purified. CAS No. 436083-30-6. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| JKC 363 | JKC 363 has been found to be a melanocortin MC4 receptor antagonist and could suppress the release of thyrotropin-releasing hormone (TRH). Synonyms: (Deamino-Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide; JKC363; JKC-363; 3-Mercaptopropionyl-Glu-His-D-2-Nal-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bond); deamino-Cys-Glu-His-D-2Nal-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asn-OH (Disulfide bridge: Cys1-Cys8); deamino-cysteinyl-L-alpha-glutamyl-L-histidyl-3-(2-naphthyl)-D-alanyl-L-arginyl-L-tryptophyl-glycyl-L-cysteinyl-L-prolyl-L-prolyl-L-lysyl-L-asparagine (1->8)-disulfide; beta-MSH (11-12)-amide, mercaptopropionic acid(11)-naphthylalanyl(14)-cysteinyl(18)-aspartyl(22)-; beta-MSH (11-22)-amide, Mrp(11)-Nal(14)-Cys(18)-Asp(22)-; [Deamino-Cys11,β-(2-Naphthyl)-D-Ala14,Cys18]-β-Melanocyte Stimulating Hormone Amide Fragment 11-22. Grades: ≥95% by HPLC. CAS No. 436083-30-6. Molecular formula: C69H91N19O16S2. Mole weight: 1506.72. | |
| JK-P3 | JK-P3 is a VEGFR2 inhibitor with IC50 values of 7.8 μM. JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but exhibits no effect on FGFR signaling in cell-based assays. It suppresses wound healing and tube formation in HUVEC without effecting endothelial cell proliferation. Synonyms: 3,4-dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)benzamide. CAS No. 942655-44-9. Molecular formula: C18H17N3O3. Mole weight: 323.352. | |
| JLK 6 | JLK 6, under the IUPAC name 7-amino-4-chloro-3-methoxyisochromen-1-one, an inhibitor of γ-secretase (IC50 = between 10 μM-1 mM) that belongs to the class of isocoumarin analogs, prevents recovery of Aβ40 and Aβ42 (IC50 < 100 μM) in HEK293 cells overexpressing wild-type and Swedish-mutant β-amyloid precursor protein (APP). Synonyms: JCP-251; JCP 251; JCP251 7-amino-4-chloro-3-methoxyisochromen-1-one; 7-Amino-4-chloro-3-methoxyisocoumarin; jlk6; 62252-26-0; JLK 6; 7-Amino-4-chloro-3-methoxy-isocoumarin; gamma-Secretase Inhibitor XI; 7-amino-4-chloro-3-methoxyisochromen-1-one; AC1L1GQZ; AC1Q3FXG; JLK-6; CHEMBL149518; SCHEMBL3056620; CTK2F1888; AMDGKLWVCUXONP-UHFFFAOYSA-N; HMS3269N03; ZINC2523036; AR-1H3136; ZINC02523036; 7-amino-3-methoxy-4-chloroisocoumarin; AKOS024457236; NCGC00167827-01; AK396360; HE005374; HE366264; TX-017351; 7-Amino-4-chloro-3-methoxy-isochromen-1-one; 7-Amino-4-chloro-3-methoxy-1H-isochromen-1-one; 1H-2-Benzopyran-1-one, 7-amino-4-chloro-3-methoxy-; BRD-K22010301-001-01-2; JLK 6|7-Amino-4-chloro-3-methoxy-1H-2-benzopyran; JLK 6; 7-AMINO-4-CHLORO-3-METHOXY-1H-2-BENZOPYRAN. CAS No. 62252-26-0. Molecular formula: C10H8ClNO3. Mole weight: 225.63. | |
| JLK 6 | JLK 6. Group: Biochemicals. Grades: Purified. CAS No. 62252-26-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| JM-6 | JM6 is a prodrug inhibitor of kynurenine 3-monooxygenase (KMO). It could increase kynurenic acid levels and reduces extracellular glutamate in the brain. It prevents spatial memory deficits, anxiety-related behavior, and synaptic loss in mouse model of Alzheimer disease. It also extends life span, prevents synaptic loss, and decreases microglial activation in a mouse model of Huntington's disease. It also plays an important role in the inhibitory effects towards kynurenine 3-monooxygenase in blood ameliorates neurodegeneration, including Alzheimer's and Huntington's diseases. Uses: Jm6 plays an important role in the inhibitory effects towards kynurenine 3-monooxygenase in blood ameliorates neurodegeneration, including alzheimer's and huntington's diseases. Synonyms: JM6; JM-6; JM 6. 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-5-(1-piperidinylmethyl)-2-thiazolyl]-benzenesulfonamide;2-(3,4-Dimethoxybenzenesulfonylamino)-4-(3-nitrophenyl)-5-(piperidin-1-yl)methylthiazole. Grades: >98 %. CAS No. 1008119-83-2. Molecular formula: C23H26N4O6S2. Mole weight: 518.60. | |
| JMJD Histone Demethylase Inhibitor III ( (E) -4- (Hydroxy (4- (4- ( (naphthalen-1-ylcarbamoyloxy) methyl) benzylamino) butyl) amino) -4-oxobut-2-enoic Acid) | A substrate (methyl lysine) and cofactor (a-ketoglutarate) mimicking bivalent benzylamino-butylamino-N-hydroxybutenoic acid compound that acts as a selective in vitro inhibitor of Jumonji domain-containing histone demethylases (JHDMs; IC50=4.3, 3.4, 5.9, 10 and 43uM for JMJD2A, JMJD2C, JMJD2E, PHF8 and JMJD3, respectively) over LSD1, asparaginyl and prolyl hydroxylases, and histone deacetylases (IC50=54, 83, 31, 22, 620, 680 and >800uM for PHD1, PHD2, PHD3, FIH, LSD1 and HDACs, respectively). The cellular active JHDM Inhibitor, Methylstat is also available. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| JMJD Histone Demethylase Inhibitor IV, Methylstat ( (E) -Methyl-4- (hydroxy (4- ( (4- ( ( (naphthalen-1-ylcarbamoyl) oxy) methyl) benzyl) amino) butyl) amino) -4-oxobut-2-enoate, Histone Lysine Demethylase Inhibitor VII, Methylstat) | A methyl ester prodrug of in vitro active N-hydroxybutenoic acid compound that is shown to preferentially induce hypermethylation of histone proteins (EC50 for H3K4me3 and H3K9me3=10.3 and 8.6uM in KYSE150 cells, and 6.7 and 6.3uM in MCF7 cells, respectively), and arrests cell growth. Acts as a selective inhibitor of Jumonji domain-containing histone demethylases (JHDMs) over prolyl hydroxylases (PHDs), and prevents myogenesis through inhibition of H3K27 demethylase UTX in C2C12 cells at 2uM. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| JMS-17-2 | JMS-17-2 is a potent and selective antagonist of CX3CR1. Uses: Designed for use in research and industrial production. Additional or Alternative Names: JMS-17-2; JMS172; JMS 17 2; JMS17-2; JMS-172; JMS 17-2; JMS-17 2. Product Category: Antagonists. Appearance: Solid powder. CAS No. 1380392-05-1. Molecular formula: C25H26ClN3O. Mole weight: 419.95. Purity: >98%. IUPACName: 5-(3-(4-(4-Chlorophenyl)piperidin-1-yl)propyl)pyrrolo[1,2-a]quinoxalin-4(5H)-one. Canonical SMILES: O=C1C2=CC=CN2C3=C(C=CC=C3)N1CCCN4CCC(C5=CC=C(Cl)C=C5)CC4. Product ID: ACM1380392051. Alfa Chemistry ISO 9001:2015 Certified. Categories: J-M172. |  |
| JMS-17-2 | JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC 50 of 0.32 nM. JMS-17-2 impairs metastatic seeding and colonization of breast cancer cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1380392-05-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-123918. | |
| JMS 17-2 hydrochloride | JMS 17-2 is a CX3CR1 antagonist. Inhibition of CX3CR1 by JMS 17-2 was indicated to impair metastatic seeding and colonization of breast cancer cells. Synonyms: 5-[3-[4-(4-Chlorophenyl)-1-piperidinyl]propyl]pyrrolo[1,2-a]quinoxalin-4(5H)-one hydrochloride. Grades: ≥98% by HPLC. Molecular formula: C25H26ClN3O·HCl. Mole weight: 456.41. | |
| JMV3002 | JMV3002 is an endogenous ligand for the growth hormone secretagogue receptor (GHSR). It decreased food intake in fasted lean mice in a dose-dependent manner with ED50 value of 2.05 mg/kg, suggesting its potential use in diet-induced obesity (DIO) treatment. Synonyms: N-[1-[4-[(2,4-dimethoxyphenyl)methyl]-5-(2-phenylethyl)-1,2,4-triazol-3-yl]-2-(1H-indol-3-yl)ethyl]pyridine-2-carboxamide. Grades: ≥98%. CAS No. 925239-03-8. Molecular formula: C35H34N6O3. Mole weight: 586.7. | |
| JMV 390-1 | JMV 390-1. Group: Biochemicals. Grades: Purified. CAS No. 148473-36-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| JMV 390-1 | JMV 390-1 has been found to be an inhibitor of the major neurotensin and neuromedin N degrading enzymes and could probably show analgesic activities. Synonyms: Jmv-390-1; Jmv390-1; N-[(2R)-4-Hydroxyamino)-1,4-dioxo-2-(phenylmethyl)butyl]-L-isoleucyl-L-leucine. Grades: ≥95% by HPLC. CAS No. 148473-36-3. Molecular formula: C23H35N3O6. Mole weight: 449.54. | |
| JMV 449 | JMV 449. Group: Biochemicals. Grades: Purified. CAS No. 139026-66-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| JMV 449 | JMV 449 could be a neurotensin receptor agonist peptide and has been found to show hypothermic and analgesic activities in the mouse. Synonyms: JMV-449; JMV449; (S)-1-de-L-lysine-2-[N2-(2,6-diaminohexyl)-L-lysine]-neuromedin N (pig spinal cord); H-Lysy(CH2NH)Lys-Pro-Tyr-Ile-Leu-OH. Grades: ≥95% by HPLC. CAS No. 139026-66-7. Molecular formula: C38H66N8O7. Mole weight: 746.96. | |
| JMV 449 acetate | JMV 449 acetate is a potent neurotensin receptor agonist. JMV 449 acetate shows an IC 50 of 0.15 nM for inhibition of 125 I-neurotensin binding to neonatal mouse brain and an EC 50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 acetate has highly potent and long-lasting hypothermic and analgesic effects in the mouse [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 141863-45-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1256C. | |
| JNJ 0966 | JNJ 0966 is a selective inhibitor of MMP-9 (IC50 = 440 nM) with no effect on MMP-1, MMP-2, MMP-3, MMP-9, or MMP-14 catalytic activity. JNJ 0966 was indicated to alleviate the pain of experimental autoimmune encephalomyelitis in a mouse model. Synonyms: JNJ-0966; JNJ0966; N-[2-[(2-Methoxyphenyl)amino]-4'-methyl[4,5'-bithiazol]-2'-yl]acetamide. Grades: ≥98% by HPLC. CAS No. 315705-75-0. Molecular formula: C16H16N4O2S2. Mole weight: 360.45. | |
| JNJ10181457 | JNJ10181457 dihydrochloride is a selective non-imidazole brain penetrant histamine H3 receptor antagonist with pKi values of 8.15 and 8.93 for rat and human H3 receptors respectively. It increases acetylcholine and extracellular norepinephrine levels in rat frontal cortex, but it does not stimulate dopamine release. It normalizes acetylcholine neurotransmission and shows efficacy in translational rat models of cognition. Uses: Jnj10181457 dihydrochloride normalizes acetylcholine neurotransmission. Synonyms: JNJ-10181457; JNJ10181457; JNJ 10181457; JNJ-10181457 dihydrochloride;4-[[3-(4-piperidin-1-ylbut-1-ynyl)phenyl]methyl]morpholine dihydrochloride. Grades: >98 %. CAS No. 544707-19-9. Molecular formula: C20H28N2O. Mole weight: 312.4. | |
| JNJ 10181457 | JNJ 10181457. Group: Biochemicals. Alternative Names: 4- [3- [4- [Piperidinyl] but-1-ynyl] benzyl] morpholine. Grades: Highly Purified. CAS No. 544707-19-9. Pack Sizes: 10mg. Molecular Formula: C20H28N2O, Molecular Weight: 312.45. US Biological Life Sciences. | Worldwide |
| JNJ 10181457 dihydrochloride | The hydrochloride salt form of JNJ 10181457, which has been found to be a histamine H3 receptor inhibitor and could be a brain penetrant. Synonyms: JNJ 10181457 dihydrochloride; JNJ10181457 dihydrochloride; JNJ-10181457 dihydrochloride; 4-[3-[4-[Piperidinyl]but-1-ynyl]benzyl]morpholine dihydrochloride. Grades: ≥98% by HPLC. CAS No. 544707-20-2. Molecular formula: C20H28N2O.2HCl. Mole weight: 385.37. | |
| JNJ-10191584 | JNJ-10191584 is a selective histamine H4 receptor antagonist. It inhibits mast cell in vitro with IC50 value of 138nM. JNJ-10191584 has antiinflammatory and analgesic effects in animal studies of acute inflammation. No development was reported for the treatment of Allergic rhinitis, Atopic dermatitis, Pruritus and Respiratory tract disorders. Uses: Allergic rhinitis; atopic dermatitis; pruritus; respiratory tract disorders. Synonyms: JNJ-10191584; JNJ10191584; JNJ 10191584; VUF-6002; VUF 6002; VUF6002; (5-Chloro-1H-benzimidazol-2-yl)(4-methylpiperazin-1-yl)methanone;869497-75-6(maleate). Grades: 98%. CAS No. 73903-17-0. Molecular formula: C13H15ClN4O. Mole weight: 278.74. | |
| JNJ 10191584 maleate | The maleate salt form of JNJ 10191584, which has been found to be a selective histamine H4 receptor silent antagonist and could restrain mast cell and eosinophil chemotaxis in vitro. Synonyms: VUF6002; VUF 6002; VUF-6002; JNJ-10191584 maleate; JNJ 10191584 maleate; JNJ10191584 maleate; 1-[(5-Chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazine maleate. Grades: ≥99% by HPLC. CAS No. 869497-75-6. Molecular formula: C13H15ClN4O.C4H4O4. Mole weight: 394.81. | |
| JNJ 10191584 maleate | JNJ 10191584 maleate. Group: Biochemicals. Grades: Purified. CAS No. 869497-75-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| JNJ-10198409 | JNJ-10198409 is a relatively selective, orally active, and ATP competitive PDGF-RTK (platelet-derived growth factor receptor tyrosine kinase) inhibitor ( IC 50 =2 nM). It is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent. JNJ-10198409 has good activity against PDGFR-β kinase ( IC 50 =4.2 nM) and PDGFR-α kinase ( IC 50 =45 nM) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 627518-40-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg. Product ID: HY-W011266. | |
| JNJ-10198409 | JNJ-10198409, also known as RWJ-540973, is an inhibitor of PDGF-BB tyrosine kinase with an IC50 value of 4.2 nM. JNJ-10198409 is a competitive antagonist of the ATP binding and hydrolysis at this receptor, resulting in a dose dependent inhibition of tumor growth and angiogenesis. Uses: Designed for use in research and industrial production. Additional or Alternative Names: JNJ-10198409; JNJ 10198409; JNJ10198409; RWJ-540973; RWJ 540973; RWJ540973. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 627518-40-5. Molecular formula: C18H16FN3O2. Mole weight: 325.34. Purity: >98%. IUPACName: N-(3-fluorophenyl)-1,4-dihydro-6,7-dimethoxy-indeno[1,2-c]pyrazol-3-amine. Canonical SMILES: COC1=CC2=C(C=C1OC)CC3=C2NN=C3NC4=CC=CC(F)=C4. Product ID: ACM627518405-1. Alfa Chemistry ISO 9001:2015 Certified. | |
| JNJ10229570 | JNJ10229570 is a novel MC1R and MC5R antagonist. It was used to treat primary human sebaceous cells. It might have a potential for the treatment of acne and other sebaceous gland pathologies. It was developed by Johnson & Johnson. It was in phase II clinical trials, but has been terminated. Uses: Jnj10229570 was used to treat primary human sebaceous cells. it might have a potential for the treatment of acne and other sebaceous gland pathologies. Synonyms: JNJ-10229570; JNJ10229570; JNJ 10229570; UNII-N9IX402L35;2,3-Bis(2-methoxyphenyl)-N-phenyl-1,2,4-thiadiazol-5-imine;Benzenamine, N-(2,3-bis(2-methoxyphenyl)-1,2,4-thiadiazol-5(2H)-ylidene)-. Grades: 98%. CAS No. 524923-88-4. Molecular formula: C22H19N3O2S. Mole weight: 389.47. | |
| JNJ-10258859 | JNJ-10258859 is a novel, potent, and selective phosphodiesterase type 5 inhibitor 5 with a K(I) of 0.23 nM and displayed excellent selectivity versus phosphodiesterase types 1-4. Uses: Phosphodiesterase type 5 inhibitor. Synonyms: JNJ-10258859; JNJ 10258859; JNJ10258859; UNII-4NPX9224XR. (3R)-3-(2,3-dihydro-1-benzofuran-5-yl)-2-[5-(4-methoxyphenyl)pyrimidin-2-yl]-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one. Grades: ≥98%. CAS No. 374927-03-4. Molecular formula: C30H24N4O3. Mole weight: 488.54. | |
| JNJ10311795 | JNJ10311795 is a dual inhibitor of Chymase and leukocyte Proteases Cathepsin G. It has inflammation therapeutic efficacy in animals models. Uses: Jnj10311795 has inflammation therapeutic efficacy. Synonyms: JNJ-10311795; JNJ 10311795; JNJ10311795. [2-[3-[Methyl-[1-(naphthalene-2-carbonyl)piperidin-4-yl]carbamoyl]naphthalen-2-yl]-1-naphthalen-1-yl-2-oxoethyl]phosphonic acid;Phosphonic acid, (2-(3-((methyl(1-(2-naphthalenylcarbonyl)-4-piperidinyl)amino)carbonyl)-2-naphthalenyl)-1-(1-naph. Grades: 98%. CAS No. 518062-14-1. Molecular formula: C40H35N2O6P. Mole weight: 670.70. | |
| JNJ-10329670 | JNJ-10329670 represents a novel class of immunosuppressive compounds with a highly potent (Ki ~30 nM). Uses: Immunosuppressant. Synonyms: JNJ-10329670; JNJ 10329670; JNJ10329670. 1-(3-(4-(6-chloro-2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)propyl)-4,5,6,7-tetrahydro-5-(methylsulfonyl)-3-(4-(trifluoromethyl)phenyl)-1H-Pyrazolo(4,3-C)pyridine. Grades: ≥98%. CAS No. 400797-24-2. Molecular formula: C30H34ClF3N6O3S. Mole weight: 651.14. | |
| JNJ 10397049 | JNJ 10397049. Group: Biochemicals. Alternative Names: N-(2,4-Dibromophenyl)-N'-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]-urea; 1-(2,4-Dibromophenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)urea. Grades: Highly Purified. CAS No. 708275-58-5. Pack Sizes: 1mg. Molecular Formula: C19H20Br2N2O3, Molecular Weight: 484.18. US Biological Life Sciences. | Worldwide |
| JNJ-10397049 | JNJ-10397049 is a potent and selective orexin 2 receptor (OX 2 R) antagonist, with a pK i of 8.3. JNJ-10397049 is 600-fold selective for the OX 2 R over the OX 1 R [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 708275-58-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10896. | |
| JNJ-10397049 | JNJ-10397049 is a selective orexin-2 receptor (OX2) antagonist. pIC50 is 7.4 for chimeric OX2 receptors/ pKB values are 5.9 for OX1 and 8.5 for OX2 receptors respectively. JNJ-10397049 exhibits no significant activity in a panel of over 50 other neurotransmitters and neuropeptide receptors. It achieves high level of OX2 receptor occupancy in the rat brain. Synonyms: JNJ-10397049; JNJ 10397049; JNJ10397049; 1-(2,4-Dibromophenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-(1,3)dioxan-5-yl)urea. Grades: 98%. CAS No. 708275-58-5. Molecular formula: C19H20Br2N2O3. Mole weight: 484.19. | |
| JNJ-1250132 | JNJ-1250132, a new steroidal progestin antagonist, inhibits binding of the receptor to DNA in vitro. JNJ-1250132 induces a receptor conformation more similar to that induced by mifepristone, which promotes receptor binding to DNA. Synonyms: [(8S,11R,13S,14S,17R)-17-acetyl-13-methyl-3-oxo-11-(4-piperidin-1-ylphenyl)-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate; JNJ-1250132; JNJ 1250132; JNJ1250132. Grades: >98%. CAS No. 240805-96-3. Molecular formula: C33H41NO4. Mole weight: 515.68. | |
| JNJ16259685 | JNJ16259685 is a selective antagonist of mGlu1 receptor , and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC 50 of 19 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 409345-29-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100407. | |
| JNJ 16259685 | JNJ 16259685. Group: Biochemicals. Alternative Names: (3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)(cis-4-methoxycyclohexyl)-methanone. Grades: Highly Purified. CAS No. 409345-29-5. Pack Sizes: 10mg. Molecular Formula: C20H23NO3, Molecular Weight: 325.399999999999. US Biological Life Sciences. | Worldwide |
| JNJ 16259685 | JNJ 16259685, a pyrano-quinolin derivative, has been found to be a metabotropic glutamate receptor-1 antagonist. Synonyms: JNJ16259685; JNJ 16259685; JNJ-16259685; (3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone. Grades: ≥98% by HPLC. CAS No. 409345-29-5. Molecular formula: C20H23NO3. Mole weight: 325.41. | |
| JNJ 1661010 | JNJ 1661010. Group: Biochemicals. Grades: Purified. CAS No. 681136-29-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| JNJ-1661010 | JNJ-1661010 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 10 nM (rat) and 12 nM (human), exhibits >100-fold selectivity for FAAH-1 when compared to FAAH-2. Synonyms: Takeda-25; N1-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide; JNJ 1661010; JNJ1661010; N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide. Grades: ≥98%. CAS No. 681136-29-8. Molecular formula: C19H19N5OS. Mole weight: 365.45. | |
| JNJ 17029259 | JNJ 17029259 is an selective, nanomolar inhibitors of the vascular endothelial growth factor receptor-2 (VEGF-R2), blocks VEGF-stimulated mitogen-activated protein kinase signaling, proliferation/migration. Uses: Vascular endothelial growth factor receptor-2 (vegf-2) kinase inhibitor. Synonyms: JNJ-17029259; JNJ 17029259; JNJ17029259. 4-[4-(2-aminopropan-2-yl)phenyl]-2-[4-(2-morpholin-4-ylethyl)anilino]pyrimidine-5-carbonitrile. Grades: ≥98%. CAS No. 314267-57-7. Molecular formula: C26H30N6O. Mole weight: 442.56. | |
| JNJ17156516 | JNJ17156516 is a potent, novel and selective cholecystokinin 1 receptor antagonist. It showed high-affinity at the cloned human and canine CCK1 receptors. It was also highly selective for the CCK1 receptor compared with the CCK2 receptor across the same species. Synonyms: JNJ-17156516; JNJ 17156516; JNJ17156516; (S)-3-(5-(3,4-Dichlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl)-2-(3-methylphenyl)propionic acid. Grades: 98%. CAS No. 649551-06-4. Molecular formula: C26H22Cl2N2O3. Mole weight: 481.37. | |
| JNJ17156516 sodium | JNJ17156516 sodium is the sodium salt form of JNJ17156516, which is a potent, novel and selective cholecystokinin 1 receptor antagonist. It showed high-affinity at the cloned human and canine CCK1 receptors. It was also highly selective for the CCK1 receptor compared with the CCK2 receptor across the same species. Synonyms: JNJ-17156516 sodium; JNJ 17156516 sodium; JNJ17156516 sodium; 1H-Pyrazole-3-propanoic acid, 5-(3,4-dichlorophenyl)-1-(4-methoxyphenyl)-alpha-(3-methylphenyl)-, sodium salt (1:1), (alphaS)-;(S)-3-(5-(3,4-Dichlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl)-2-(3-methylphenyl)propionic acid sodium s. Grades: 98%. CAS No. 648861-58-9. Molecular formula: C26H21Cl2N2NaO3. Mole weight: 503.35. | |
| JNJ 17203212 | JNJ 17203212. Group: Biochemicals. Grades: Purified. CAS No. 821768-06-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| JNJ-17203212 | JNJ-17203212 is a novel, reversible, and selective TRPV1 antagonist which could not inhibit related TRP channels. Its IC50 values are 65 nM and 102 nM for human TRPV1 and rat TRPV1. It could reduce sensitivity to luminal distension in both an acute, noninflammatory and a chronic, post-inflammatory rodent model of colonic hypersensitivity. It inhibits capsaicin- and H+-induced channel activation, which pIC50 values are 6.32 and 7.23 respectively. It exhibits antitussive and analgesic activity in vivo. Uses: Jnj-17203212 could reduce sensitivity to luminal distension in both an acute, noninflammatory and a chronic, post-inflammatory rodent model of colonic hypersensitivity. it inhibits capsaicin- and h+-induced channel activation. it exhibits antitussive and analgesic activity in vivo. Synonyms: JNJ-17203212; JNJ 17203212; JNJ17203212. 4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide;1-PiperazinecarboxaMide, 4-[3-(trifluoroMethyl)-2-pyridinyl]-N-[5-(trifluoroMethyl)-2-pyridinyl]-;N1-(3-Trifluoromethylpyrid-2-yl)-N4-(4-trifluoromethylpyrid-2-yl)carbamoylpiperazine. Grades: >99 %. CAS No. 821768-06-3. Molecular formula: C17H15F6N5O. Mole weight: 419.32. | |
| JNJ-17203212 | JNJ-17203212 is a selective, potent and competitive TRPV1 antagonist. JNJ-17203212 is developed for researching pain management, such as migraine [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 821768-06-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100129. | |
| JNJ-18038683 | JNJ-18038683 is a 5-Hydroxytryptamine Type 7 ( 5-HT 7 ) receptor antagonist, with pK i s of 8.19, 8.20 for rat and human 5-HT 7 in HEK293 cells, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 851376-05-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19889. | |
| JNJ-19567470 | JNJ-19567470 is a selective Corticotropin releasing factor (CRF) receptor antagonist. It is a novel target for developing anti-panic drugs. JNJ-19567470 is as effective as benzodiazepines in treatment of a panic attack which prevents sodium lactate-induced acute panic-like responses. In Oct 2009, preclinical development in Anxiety disorders was ongoing in Japan. Uses: Anxiety disorders. Synonyms: JNJ-19567470; JNJ19567470; JNJ 19567470; TAI-041; TAI 041; TAI041; R-317573;1-(7-(4-bromo-2,6-dimethylphenyl)-2,5-dimethyl-7H-pyrrolo(2,3-d)pyrimidin-4-yl)-4-Piperidinemethanol. Grades: 98%. CAS No. 724471-26-5. Molecular formula: C22H27BrN4O. Mole weight: 443.38. | |
| JNJ 20788560 | JNJ-20788560 is a delta opioid agonist analgesics. No recent reports of development identified for preclinical development in Inflammatory-pain in USA. Uses: Inflammatory pain; pain. Synonyms: JNJ-20788560; JNJ 20788560; JNJ20788560; 9-(8-Azabicyclo(3.2.1)oct-3-ylidene)-9H-xanthene-3-carboxylic acid diethylamide. Grades: 98%. CAS No. 825649-28-3. Molecular formula: C25H28N2O2. Mole weight: 388.51. | |
| JNJ-2408068 | JNJ-2408068 is a potent inhibitor of respiratory syncytial virus (RSV), exhibits potent antiviral activity with 50% effective concentrations (EC50s) of 1.4 and 2.1 nM, respectively. Uses: Respiratory syncytial virus inhibitor. Synonyms: R170591; R-170591; R 170591; HE066500; HE-066500; HE 066500; JNJ-2408068; JNJ 2408068; JNJ2408068. 2-[[2-[[1-(2-aminoethyl)piperidin-4-yl]amino]-4-methylbenzimidazol-1-yl]methyl]-6-methylpyridin-3-ol. Grades: ≥98%. CAS No. 317846-22-3. Molecular formula: C22H30N6O. Mole weight: 394.52. | |
| JNJ26076713 | JNJ26076713 is an orally active alpha V integrin antagonist. It may be a potential therapeutic candidate for the treatment of age-related macular degeneration,proliferative diabetic retinopathy and macular edema. Uses: Jnj26076713 may be a potential therapeutic candidate for the treatment of age-related macular degeneration,proliferative diabetic retinopathy and macular edema. Synonyms: JNJ-26076713; JNJ26076713; JNJ 26076713;3-Quinolinepropanoic acid, 1,2,3,4-tetrahydro-beta-((1-(1-oxo-3-(1,5,6,7-tetrahydro-1,8-naphthyridin-2-yl)propyl)-4-piperidinyl)methyl)-, (betaS,3S)-;(3S)-4-[1-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propanoyl]piperidin-4-yl]-3-[(3S)-1,2. Grades: 98%. CAS No. 669076-03-3. Molecular formula: C29H38N4O3. Mole weight: 490.65. | |
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