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Product
Jervine Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC 50 of 500-700 nM [1]. Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum nigrum. Jervine has anti-inflammatory and antioxidant properties [2]. Uses: Scientific research. Group: Natural products. Alternative Names: 11-Ketocyclopamine. CAS No. 469-59-0. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0836. MedChemExpress MCE
Jervine Jervine - Product ID: NST-10-170. Category: Alkaloids. Purity: 98%. Test method: HPLC. CAS No. 469-59-0. Pack Sizes: 0,05g, 0,1g, 0,25g, 0,5g. Appearance: White to off-white powder. Molecular formula: C27H39NO3. Mole weight: 425.61. Storage: +2 … +8 °C. NATURE SCIENCE TECHNOLOGIES
Jervine Jervine. Group: Biochemicals. Grades: Purified. CAS No. 469-59-0. Pack Sizes: 10mg. US Biological Life Sciences. USBiological 5
Worldwide
Jervine Jervine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling. It is an inhibitor of Smo and derived from the Veratrum plant species. Jervine can be used to induce abnormal morphogenesis in a number of experimental models. Uses: Antibacterial. Synonyms: Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one, 2, 3, 3'a, 4, 4', 5', 6, 6', 6a, 6b, 7, 7', 7'a, 8, 11a, 11b-hexadecahydro-3-hydroxy-3', 6', 10, 11b-tetramethyl-, (2'R, 3S, 3'R, 3'aS, 6'S, 6aS, 6bS, 7'aR, 11aS, 11bR)-; (2'R, 3S, 3'R, 3'aS, 6'S, 6aS, 6bS, 7'aR, 11aS, 11bR)-2, 3, 3'a, 4, 4', 5', 6, 6', 6a, 6b, 7, 7', 7'a, 8, 11a, 11b-Hexadecahydro-3-hydroxy-3', 6', 10, 11b-tetramethylspiro[9H-benzo[a]fluorene-9, 2'(3'H)-furo[3, 2-b]pyridin]-11(1H)-one; Veratraman-11-one, 17,23-epoxy-3-hydroxy-, (3β,23β)-; Jervin; NSC 23898; NSC 7520; Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one, 2, 3, 3'a, 4, 4', 5', 6, 6', 6a, 6b, 7, 7', 7'a, 8, 11a, 11b-hexadecahydro-3-hydroxy-3', 6', 10, 11b-tetramethyl-, [3S-(3α, 6aα, 6bβ, 9α(3'S*, 3'aR*, 6'R*, 7'aS*), 11aβ, 11bα)]-. Grades: >98%. CAS No. 469-59-0. Molecular formula: C27H39NO3. Mole weight: 425.60. BOC Sciences 9
Jervine ((3ß,23ß)-17,23-Epoxy-3-hydroxyveratraman-11-one) Has antibacterial properties. Jervine demonstrates teratogenic properties. It is the starting material for C-nor-D-homosteroids. Jervine induces holoprosencephaly and blocks endogenous Sonic hedgehog signaling. Group: Biochemicals. Alternative Names: (3ß,23ß)-17,23-Epoxy-3-hydroxyveratraman-11-one. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. USBiological 1
Worldwide
Jesaconitine Jesaconitine. Group: Biochemicals. Grades: Highly Purified. CAS No. 16298-90-1. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 20mg. Molecular Formula: C35H49NO12. US Biological Life Sciences. USBiological 7
Worldwide
JF5 hydrochloride ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. Alfa Chemistry Analytical Products
Jfd00244 JFD00244 is a sirtuin 2 (SIRT2) inhibitor, with anti-tumor effect. JFD00244 is also a Nsp-16 inhibitor against SARS-CoV-2. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Solid. CAS No. 96969-83-4. Molecular formula: C30H26N2O4. Mole weight: 478.54. Purity: 0.9803. Canonical SMILES: O=C1C2=C(C=CC=C2)C(C3=C(NCCC4=CC=C(O)C=C4)C=CC(NCCC5=CC=C(O)C=C5)=C13)=O. Product ID: ACM96969834. Alfa Chemistry — ISO 9001:2015 Certified. Alfa Chemistry.
JFD00244 JFD00244 is an inhibitor of sirtuin 2 (SIRT2), a NAD+-dependent protein deacetylase. It induces granulocytic differentiation in the acute promyelocytic leukemia (APL) cell line NB4. Synonyms: BML-266; 1,4-Bis[(P-hydroxyphenethyl)amino]-anthraquinone. Grades: ≥95%. CAS No. 96969-83-4. Molecular formula: C30H26N2O4. Mole weight: 478.5. BOC Sciences 10
JFD01307SC ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. Alfa Chemistry Analytical Products
JF-NP-26 JF-NP-26 is a photoactive mGlu5 receptor negative allosteric modulator. Activated by visible light, JF-NP-26 releases the active molecule (raseglurant) that blocks the mGlu5 receptor. Synonyms: (7-(Diethylamino)-2-oxo-2H-chromen-4-yl)methyl (2-((3-fluorophenyl)ethynyl)-4,6-dimethylpyridin-3-yl)carbamate. Grades: ≥98% by HPLC. CAS No. 2341841-03-8. Molecular formula: C30H28FN3O4. Mole weight: 513.56. BOC Sciences 10
JG26 JG26 is an ADAM17 inhibitor, with IC 50 values of 12 nM, 1.9 nM, 150 nM and 9.4 nM for ADAM8, ADAM17, ADAM10 and MMP-12, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1464910-32-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120852. MedChemExpress MCE
JGB1741 JGB1741 is a small-molecule inhibitor of SIRT1, a NAD+-dependent class III histone deacetylase (HDAC) which is overexpressed in many cancer cells. JGB1741 shows potent inhibitory effects against the proliferation of human metastatic breast cancer cells, MDA-MB 231. Synonyms: ILS-JGB-1741; N-Benzyl-2-[(E)-(2-hydroxynaphthalen-1-yl)methylideneamino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide. Grades: ≥98%. CAS No. 1256375-38-8. Molecular formula: C27H24N2O2S. Mole weight: 440.6. BOC Sciences 10
JH295 JH295 is an irreversible, cysteine-targeted inhibitor of the human centrosomal kinase, Nek2. JH295 irreversibly inhibited cellular Nek2 without affecting the mitotic kinases, Cdk1, Aurora B, or Plk1. Moreover, JH295 did not perturb bipolar spindle assembly or the spindle assembly checkpoint. To our knowledge, JH295 is the first small molecule shown to inactivate Nek2 kinase activity in cells. Synonyms: JH 295; JH-295; 3-[(2-Ethyl-4-methyl-1H-imidazole)-5-ylmethylene]-5-[(1-oxo-2-propynyl)amino]-1H-indole-2(3H)-one. CAS No. 1311143-71-1. Molecular formula: C18H16N4O2. Mole weight: 320.35. BOC Sciences 11
JH-II-127 JH-II-127, a Pyrrolopyrimidine derivative, is a highly potent, selective, and brain penetrant LRRK2 inhibitor, of both wild-type and G2019S mutant LRRK2. IC50: LRRK2-wild-type= 6.6 nM, LRRK2-G2019S= 2.2 nM ,LRRK2-A2016T= 47.7 nM. Synonyms: [4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone JH-II-127 (4-((5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone 1700693-08-8 JH-II127 JH-II. CAS No. 1700693-08-8. Molecular formula: C19H21ClN6O3. Mole weight: 416.86. BOC Sciences 10
JHU-083 JHU-083, a proagent of 6-diazo-5-oxo-L-norleucine (DON; HY-108357), is an orally active and selective glutaminase antagonist. JHU-083 blocks glutaminase activity in brain CD11b + cells and experimental cerebral malaria (ECM) resulting in a net decrease of glutamate levels in the animals [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1998725-11-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122218. MedChemExpress MCE
JHU-16907 Cas No. 942063-86-7. BOC Sciences 11
JHU-292 JHU-292 is the prodrug of 6-diazo-5-oxo-L-norleucine (DON), a glutaminase antagonist with therapeutic effect on hematological malignancies. Compared to DON, JH-292 exhibits excellent stability in human plasma and reduced gastrointestinal side effects. It would be metabolized to DON in tumor cells with the tumor cell/plasma DON ratio enhanced 15-fold. Uses: The treatment of hematological malignancies. Synonyms: JHU-292; JHU292. BOC Sciences 11
JHU37160 JHU37160 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist. It has high affinity in vitro for hM3Dq and hM4Di (Ki values are 1.9 nM (hM3Dq) and 3.6 nM (hM4Di). Synonyms: JHU 37160; JHU-37160. CAS No. 2369979-68-8. Molecular formula: C19H20ClFN4. Mole weight: 358.84. BOC Sciences 8
JHU395 JHU395 is an orally-bioavailable and a plasma stable lipophilic glutamine antagonists (GA) proagent. JHU395 delivers 6-diazo-5-oxo-L-norleucine (DON) to malignant peripheral nerve sheath tumor (MPNST) in vitro and in vivo, and has antitumor activity in MPNST [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2079938-92-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128775. MedChemExpress MCE
JHW 007 hydrochloride JHW 007 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 202645-74-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. USBiological 5
Worldwide
JHW 007 hydrochloride The hydrochloride salt form of JHW 007, which is a dopamine uptake inhibitor and could also restrain the effects of cocaine in a dose-dependent manner. Synonyms: JHW 007 hydrochloride; JHW007 hydrochloride; JHW-007 hydrochloride; (3-endo)-3-[Bis(4-fluorophenyl)methoxy]-8-butyl-8-azabicyclo[3.2.1]octane hydrochloride. Grades: ≥99% by HPLC. CAS No. 202645-74-7. Molecular formula: C24H29F2NO.HCl. Mole weight: 421.95. BOC Sciences 11
JH-X-119-01 Jh-X-119-01 is a novel potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 irreversibly labels IRAK1 at C302. This compound exhibited cytotoxic activity at single digit micromolar concentrations in a panel of WM, DLBCL, and lymphoma cell lines expressing MYD88. Cotreatment of JH-X-119-01 with the BTK inhibitor ibrutinib resulted in synergistic killing effects in these systems. Uses: Designed for use in research and industrial production. Additional or Alternative Names: JH-X-119-01; JH-X119-01; JH-X 119-01; JH-X-11901; JH-X11901; JH-X 11901; JHX-11901; JHX11901; JHX 11901. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2227368-54-7. Molecular formula: C25H20N6O3. Mole weight: 452.47. Purity: >98%. IUPACName: N-(4-(3-Acrylamidobenzamido)phenyl)-6-(1H-pyrazol-5-yl)picolinamide. Canonical SMILES: O=C(NC1=CC=C(NC(C2=CC=CC(NC(C=C)=O)=C2)=O)C=C1)C3=NC(C4=CC=NN4)=CC=C3. Product ID: ACM2227368547. Alfa Chemistry — ISO 9001:2015 Certified. Alfa Chemistry.
JH-X-119-01 JH-X-119-01 is a potent and selective interleukin-1 receptor-associated kinases 1 ( IRAK1 ) inhibitor. JH-X-119-01 ameliorates LPS-induced sepsis in mice [1]. JH-X-119-01 inhibits IRAK1 biochemically with an apparent IC 50 of 9 nM while exhibiting no inhibition of IRAK4 at concentrations up to 10 μM [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2227368-54-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103017A. MedChemExpress MCE
JH-X-119-01 hydrochloride JH-X-119-01 hydrochloride is a potent and selective interleukin-1 receptor-associated kinases 1 ( IRAK1 ) inhibitor. JH-X-119-01 hydrochloride ameliorates LPS-induced sepsis in mice [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2591344-30-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-103017. MedChemExpress MCE
JH-X-119-01 hydrochloride A potent IRAK1 inhibitor. Synonyms: JH-X-119-01 (hydrochloride). CAS No. 2591344-30-6. Molecular formula: C25H21ClN6O3. Mole weight: 488.93. BOC Sciences 9
JI-101 JI-101 is an orally active inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor beta (PDGFRb), and the ephrin B4 receptor B4 (EphB4) with potential antiangiogenic and antineoplastic activities. Angiogenesis inhibitor JI-101 binds to and inhibits VEGFR2, PDGFRb and EphB4, which may inhibit tumor angiogenesis and, so, cellular proliferation in tumor cells overexpressing VEGFR2, PDGFRb and EphB4. The receptor tyrosine kinases VEGFR2, PDGFRb and EphB4 may be overexpressed in a number of different cancer cell types and may play crucial roles in tumor angiogenesis. Synonyms: N-[1-[(2-Amino-4-pyridinyl)methyl]-1H-indol-4-yl]-N'-(5-bromo-2-methoxyphenyl)urea; 1-[1-[(2-Aminopyridin-4-yl)methyl]-1H-indol-4-yl]-3-(5-bromo-2-methoxyphenyl)urea; CGI 1842; JI101; JI 101. Grades: 98%. CAS No. 900573-88-8. Molecular formula: C22H20BrN5O2. Mole weight: 466.33. BOC Sciences 10
JIB 04 JIB 04. Group: Biochemicals. Grades: Purified. CAS No. 199596-05-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. USBiological 5
Worldwide
JIB-04 JIB-04 Inhibitor. Uses: Scientific use. Product Category: T1868. CAS No. 199596-05-9. TARGETMOL CHEMICALS
JIB-04 ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. Alfa Chemistry Analytical Products
JIB-04 JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC 50 s of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 199596-05-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13953. MedChemExpress MCE
JIB-04 JIB-04 is a potent, selective and cell-permeable inhibitor used in compound for cancer research. It targets the histone demethylase KDM5A and effectively suppresses the growth of various cancer cells like triple-negative breast cancer and acute myeloid leukemia. Synonyms: JIB04; JIB-04; JIB 04; NSC 693627; NSC-693627; NSC 693627. CAS No. 199596-05-9. Molecular formula: C17H13ClN4. Mole weight: 308.769. BOC Sciences 10
Jietacin A Jietacin A is originally isolated from Str. sp. KP-197. It is found to be resistant to nematode, it can 100% kill Burs helenchus Lignicolus with the concentration of 0.25μg/mL, which is 10 times stronger than Avermectin B1a. Synonyms: Jietacine A; BRN 5538455; 1-(Ethenyl-ONN-azoxy)-14-methyl-8-pentadecanone. CAS No. 109766-61-2. Molecular formula: C18H34N2O2. Mole weight: 310.47. BOC Sciences 5
Jietacin B Jietacin B is originally isolated from Str. sp. KP-197. It is found to be resistant to nematode, it can 100% kill Burs helenchus Lignicolus with the concentration of 0.25μg/mL, which is 10 times stronger than Avermectin B1a. CAS No. 109766-62-3. Molecular formula: C19H36N2O2. Mole weight: 324.50. BOC Sciences 5
Jindongenin-1a Jindongenin-1a is an antibacterial peptide isolated from Amolops jingdongensis (Chinese torrent frog). It has activity against gram-positive bacteria, gram-negative bacteria and fungi. Jindongenin-1a can help to solve the serious problem of bacterial resistance to currently used antibiotics. Synonyms: Ser-Met-Gly-Ala-Val-Lys-Leu-Ala-Lys-Leu-Leu-Ile-Asp-Lys-Met-Lys-Cys-Glu-Val-Thr-Lys-Ala-Cys. Grades: 95.6%. BOC Sciences 4
Jingdongin-1 Jingdongin-1 is an antibacterial peptide isolated from Amolops jingdongensis (Chinese torrent frog). It has activity against gram-positive bacteria, gram-negative bacteria and fungi. Synonyms: Phe-Leu-Pro-Leu-Phe-Leu-Pro-Lys-Ile-Ile-Cys-Val-Ile-Thr-Lys-Lys-Cys. Grades: 96.4%. Mole weight: 1976.6. BOC Sciences 4
Jingzhaotoxin III Jingzhaotoxin III. Group: Biochemicals. Grades: Purified. CAS No. 925463-91-8. Pack Sizes: 100ug. US Biological Life Sciences. USBiological 5
Worldwide
Jingzhaotoxin III Jingzhaotoxin III is a selective blocker of NaV1.5 channels with IC50 value of 348 nM. It is selective for NaV1.5 channels and shows no effect on other isoforms. It inhibits the activation of cardiac sodium channels by binding to the NaV1.5 S3-S4 linker of domain II. It has no effect on sodium channels in dorsal root ganglion neurons. Synonyms: H-Asp-Gly-Glu-Cys(1)-Gly-Gly-Phe-Trp-Trp-Lys-Cys(2)-Gly-Arg-Gly-Lys-Pro-Pro-Cys(3)-Cys(1)-Lys-Gly-Tyr-Ala-Cys(2)-Ser-Lys-Thr-Trp-Gly-Trp-Cys(3)-Ala-Val-Glu-Ala-Pro-OH; L-alpha-aspartyl-glycyl-L-alpha-glutamyl-L-cysteinyl-glycyl-glycyl-L-phenylalanyl-L-tryptophyl-L-tryptophyl-L-lysyl-L-cysteinyl-glycyl-L-arginyl-glycyl-L-lysyl-L-prolyl-L-prolyl-L-cysteinyl-L-cysteinyl-L-lysyl-glycyl-L-tyrosyl-L-alanyl-L-cysteinyl-L-seryl-L-lysyl-L-threonyl-L-tryptophyl-glycyl-L-tryptophyl-L-cysteinyl-L-alanyl-L-valyl-L-alpha-glutamyl-L-alanyl-L-proline (4->19),(11->24),(18->31)-tris(disulfide). Grades: >98%. CAS No. 925463-91-8. Molecular formula: C174H241N47O46S6. Mole weight: 3918.44. BOC Sciences 3
Jionoside A1 Jionoside A1. Group: Biochemicals. CAS No. 120444-60-2. Pack Sizes: 5mg. US Biological Life Sciences. USBiological 9
Worldwide
Jionoside B1 Jionoside B1. Group: Biochemicals. Grades: Plant Grade. CAS No. 120406-37-3. Pack Sizes: 5mg. Molecular Formula: C37H50O20, Molecular Weight: 814.79. US Biological Life Sciences. USBiological 9
Worldwide
JIP-1 (153-163) JIP-1 (153-163) has been found to be a peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (JIP-1). Synonyms: TI-JIP. Grades: >98%. CAS No. 438567-88-5. Molecular formula: C61H104N20O14. Mole weight: 1341.6. BOC Sciences 3
JIP-1 (153-163) acetate JIP-1 (153-163) acetate is a c-Jun N-terminal kinase (JNK) peptide inhibitor based on JNK-interacting protein-1 (JIP-1) residues 153-163. It binds to JNK with affinity in the micromolar range and minimally inhibits p38 and ERK. Synonyms: L-Phenylalaninamide, L-arginyl-L-prolyl-L-lysyl-L-arginyl-L-prolyl-L-threonyl-L-threonyl-L-leucyl-L-asparaginyl-L-leucyl-, acetate (1:1); H-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH2.CH3CO2H; L-arginyl-L-prolyl-L-lysyl-L-arginyl-L-prolyl-L-threonyl-L-threonyl-L-leucyl-L-asparagyl-L-leucyl-L-phenylalaninamide acetate salt. Grades: ≥95%. CAS No. 1417623-78-9. Molecular formula: C61H104N20O14.C2H4O2. Mole weight: 1401.66. BOC Sciences 6
JJH260 JJH260 is an inhibitor of androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). JJH260 was shown to found members of an evolutionarily conserved class of transmembrane threonine hydrolases involved in bioactive lipid metabolism. Synonyms: 7-(4-(dimethylamino)benzoyl)-1,3-dioxohexahydroimidazo[1,5-a]pyrazin-2(3H)-yl 4-(4-chlorophenethyl)piperidine-1-carboxylate. Grades: ≥90%. CAS No. 1831135-30-8. Molecular formula: C29H34ClN5O5. Mole weight: 568.1. BOC Sciences 9
JJKK 048 JJKK 048. Group: Biochemicals. Grades: Purified. CAS No. 1515855-97-6. Pack Sizes: 10mg. US Biological Life Sciences. USBiological 5
Worldwide
JJKK 048 JJKK 048 is a highly selective and potent monoacylglycerol lipase (MAGL) inhibitor with IC 50 values of 214 pM, 275 pM and 363 pM for human, rat, and mouse MAGL. JJKK 048 displays low cross-reactivity with other endocannabinoid targets. JJKK 048 can be used in the research of diseases such as cancer, neurodegenerative diseases, and pain [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1515855-97-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108613. MedChemExpress MCE
JJKK 048 JJKK 048, a benzodioxol derivative, has been found to a MAGL inhibitor that could probably be significant in anticancer and anti-inflammatory studies. IC50: 0.4 nM. Synonyms: JJKK048; JJKK-048; JJKK 048; MolPort-035-941-193; BDBM50065646; AKOS025142062; ZINC103287208; [4-[bis(1,3-benzodioxol-5-yl)methyl]piperidin-1-yl]-(1,2,4-triazol-1-yl)methanone. Grades: 98%. CAS No. 1515855-97-6. Molecular formula: C23H22N4O5. Mole weight: 434.44. BOC Sciences 9
JJKK-048 ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. Alfa Chemistry Analytical Products 2
JK184 ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. Alfa Chemistry Analytical Products
JK 184 JK 184. Group: Biochemicals. Grades: Purified. CAS No. 315703-52-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. USBiological 5
Worldwide
JK-184 JK-184 is a potent downstream hedgehog (Hh) signaling antagonist that functions by alcohol dehydrogenase 7 (Adh7) inhibition, preventing Gli-dependent transcriptional activity (IC50 = 30 nM). Hedgehog signaling plays a key role in a wide variety of developmental processes as well as cancer progression. JK-184 exhibits antiproliferative activity. Uses: Differentiation. Synonyms: JK184; JK 184. Grades: 98%. CAS No. 315703-52-7. Molecular formula: C19H18N4OS. Mole weight: 350.44. BOC Sciences 9
JK 184 (N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine) An imidazopyridine derivative that acts as a potent downstream antagonist of Hedgehog(Hh) signaling pathway. JK184 functions by inhibiting class IV alcohol dehydrogenase (Aldh7) (IC50 = 210 nM). Group: Biochemicals. Alternative Names: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine. Grades: Highly Purified. CAS No. 315703-52-7. Pack Sizes: 1mg. US Biological Life Sciences. USBiological 1
Worldwide
JK-2 ?90% (NMR). Group: Fluorescence/luminescence spectroscopy. Alfa Chemistry Analytical Products 3
JKC 363 JKC 363 has been found to be a melanocortin MC4 receptor antagonist and could suppress the release of thyrotropin-releasing hormone (TRH). Synonyms: (Deamino-Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide; JKC363; JKC-363; 3-Mercaptopropionyl-Glu-His-D-2-Nal-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bond); deamino-Cys-Glu-His-D-2Nal-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asn-OH (Disulfide bridge: Cys1-Cys8); deamino-cysteinyl-L-alpha-glutamyl-L-histidyl-3-(2-naphthyl)-D-alanyl-L-arginyl-L-tryptophyl-glycyl-L-cysteinyl-L-prolyl-L-prolyl-L-lysyl-L-asparagine (1->8)-disulfide; beta-MSH (11-12)-amide, mercaptopropionic acid(11)-naphthylalanyl(14)-cysteinyl(18)-aspartyl(22)-; beta-MSH (11-22)-amide, Mrp(11)-Nal(14)-Cys(18)-Asp(22)-; [Deamino-Cys11,β-(2-Naphthyl)-D-Ala14,Cys18]-β-Melanocyte Stimulating Hormone Amide Fragment 11-22. Grades: ≥95% by HPLC. CAS No. 436083-30-6. Molecular formula: C69H91N19O16S2. Mole weight: 1506.72. BOC Sciences 10
JKC 363 JKC 363. Group: Biochemicals. Grades: Purified. CAS No. 436083-30-6. Pack Sizes: 500ug. US Biological Life Sciences. USBiological 5
Worldwide
JK-P3 JK-P3 is a VEGFR2 inhibitor with IC50 values of 7.8 μM. JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but exhibits no effect on FGFR signaling in cell-based assays. It suppresses wound healing and tube formation in HUVEC without effecting endothelial cell proliferation. Synonyms: 3,4-dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)benzamide. CAS No. 942655-44-9. Molecular formula: C18H17N3O3. Mole weight: 323.352. BOC Sciences 8
JK-P3 ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. Alfa Chemistry Analytical Products 3
JLK 6 JLK 6, under the IUPAC name 7-amino-4-chloro-3-methoxyisochromen-1-one, an inhibitor of γ-secretase (IC50 = between 10 μM-1 mM) that belongs to the class of isocoumarin analogs, prevents recovery of Aβ40 and Aβ42 (IC50 < 100 μM) in HEK293 cells overexpressing wild-type and Swedish-mutant β-amyloid precursor protein (APP). Synonyms: JCP-251; JCP 251; JCP251 7-amino-4-chloro-3-methoxyisochromen-1-one; 7-Amino-4-chloro-3-methoxyisocoumarin; jlk6; 62252-26-0; JLK 6; 7-Amino-4-chloro-3-methoxy-isocoumarin; gamma-Secretase Inhibitor XI; 7-amino-4-chloro-3-methoxyisochromen-1-one; AC1L1GQZ; AC1Q3FXG; JLK-6; CHEMBL149518; SCHEMBL3056620; CTK2F1888; AMDGKLWVCUXONP-UHFFFAOYSA-N; HMS3269N03; ZINC2523036; AR-1H3136; ZINC02523036; 7-amino-3-methoxy-4-chloroisocoumarin; AKOS024457236; NCGC00167827-01; AK396360; HE005374; HE366264; TX-017351; 7-Amino-4-chloro-3-methoxy-isochromen-1-one; 7-Amino-4-chloro-3-methoxy-1H-isochromen-1-one; 1H-2-Benzopyran-1-one, 7-amino-4-chloro-3-methoxy-; BRD-K22010301-001-01-2; JLK 6|7-Amino-4-chloro-3-methoxy-1H-2-benzopyran; JLK 6; 7-AMINO-4-CHLORO-3-METHOXY-1H-2-BENZOPYRAN. CAS No. 62252-26-0. Molecular formula: C10H8ClNO3. Mole weight: 225.63. BOC Sciences 10
JLK 6 JLK 6. Group: Biochemicals. Grades: Purified. CAS No. 62252-26-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. USBiological 5
Worldwide
JM6 ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. Alfa Chemistry Analytical Products
JM-6 JM6 is a prodrug inhibitor of kynurenine 3-monooxygenase (KMO). It could increase kynurenic acid levels and reduces extracellular glutamate in the brain. It prevents spatial memory deficits, anxiety-related behavior, and synaptic loss in mouse model of Alzheimer disease. It also extends life span, prevents synaptic loss, and decreases microglial activation in a mouse model of Huntington's disease. It also plays an important role in the inhibitory effects towards kynurenine 3-monooxygenase in blood ameliorates neurodegeneration, including Alzheimer's and Huntington's diseases. Uses: Jm6 plays an important role in the inhibitory effects towards kynurenine 3-monooxygenase in blood ameliorates neurodegeneration, including alzheimer's and huntington's diseases. Synonyms: JM6; JM-6; JM 6. 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-5-(1-piperidinylmethyl)-2-thiazolyl]-benzenesulfonamide;2-(3,4-Dimethoxybenzenesulfonylamino)-4-(3-nitrophenyl)-5-(piperidin-1-yl)methylthiazole. Grades: >98 %. CAS No. 1008119-83-2. Molecular formula: C23H26N4O6S2. Mole weight: 518.60. BOC Sciences 9
JMJD1A human recombinant, expressed in baculovirus infected Sf9 cells, ?40% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. Alfa Chemistry Analytical Products 2
JMJD2A Active human recombinant, expressed in baculovirus infected insect cells, ?70% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. Alfa Chemistry Analytical Products 2
JMJD2C Active human recombinant, expressed in baculovirus infected insect cells, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. Alfa Chemistry Analytical Products 2
JMJD2D active human recombinant, expressed in baculovirus infected Sf9 cells, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. Alfa Chemistry Analytical Products 2
JMJD3/KDM6B Active human recombinant, expressed in baculovirus infected insect cells, ?70% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. Alfa Chemistry Analytical Products 2
JMJD6 human recombinant, expressed in baculovirus infected Sf9 cells, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. Alfa Chemistry Analytical Products 2
JMJD Histone Demethylase Inhibitor III ( (E) -4- (Hydroxy (4- (4- ( (naphthalen-1-ylcarbamoyloxy) methyl) benzylamino) butyl) amino) -4-oxobut-2-enoic Acid) A substrate (methyl lysine) and cofactor (a-ketoglutarate) mimicking bivalent benzylamino-butylamino-N-hydroxybutenoic acid compound that acts as a selective in vitro inhibitor of Jumonji domain-containing histone demethylases (JHDMs; IC50=4.3, 3.4, 5.9, 10 and 43uM for JMJD2A, JMJD2C, JMJD2E, PHF8 and JMJD3, respectively) over LSD1, asparaginyl and prolyl hydroxylases, and histone deacetylases (IC50=54, 83, 31, 22, 620, 680 and >800uM for PHD1, PHD2, PHD3, FIH, LSD1 and HDACs, respectively). The cellular active JHDM Inhibitor, Methylstat is also available. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. USBiological 4
Worldwide
JMJD Histone Demethylase Inhibitor IV, Methylstat ( (E) -Methyl-4- (hydroxy (4- ( (4- ( ( (naphthalen-1-ylcarbamoyl) oxy) methyl) benzyl) amino) butyl) amino) -4-oxobut-2-enoate, Histone Lysine Demethylase Inhibitor VII, Methylstat) A methyl ester prodrug of in vitro active N-hydroxybutenoic acid compound that is shown to preferentially induce hypermethylation of histone proteins (EC50 for H3K4me3 and H3K9me3=10.3 and 8.6uM in KYSE150 cells, and 6.7 and 6.3uM in MCF7 cells, respectively), and arrests cell growth. Acts as a selective inhibitor of Jumonji domain-containing histone demethylases (JHDMs) over prolyl hydroxylases (PHDs), and prevents myogenesis through inhibition of H3K27 demethylase UTX in C2C12 cells at 2uM. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. USBiological 4
Worldwide
JMS-17-2 JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC 50 of 0.32 nM. JMS-17-2 impairs metastatic seeding and colonization of breast cancer cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1380392-05-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-123918. MedChemExpress MCE
JMS-17-2 JMS-17-2 is a potent and selective antagonist of CX3CR1. Uses: Designed for use in research and industrial production. Additional or Alternative Names: JMS-17-2; JMS172; JMS 17 2; JMS17-2; JMS-172; JMS 17-2; JMS-17 2. Product Category: Antagonists. Appearance: Solid powder. CAS No. 1380392-05-1. Molecular formula: C25H26ClN3O. Mole weight: 419.95. Purity: >98%. IUPACName: 5-(3-(4-(4-Chlorophenyl)piperidin-1-yl)propyl)pyrrolo[1,2-a]quinoxalin-4(5H)-one. Canonical SMILES: O=C1C2=CC=CN2C3=C(C=CC=C3)N1CCCN4CCC(C5=CC=C(Cl)C=C5)CC4. Product ID: ACM1380392051. Alfa Chemistry — ISO 9001:2015 Certified. Categories: J-M172. Alfa Chemistry.

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