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| Product | Description | |
|---|---|---|
| KPI-10 | KPI-10, also known as WQ3810, is a new compound currently being studied for its efficacy in the treatment of infections caused by multidrug-resistant bacteria. WQ-3810 demonstrated high potent activity against the antimicrobial-resistant pathogens tested. WQ-3810 (MIC(90)=4 mg/L and 0.06 mg/L, respectively) was also more active than ciprofloxacin (64 mg/L and 2 mg/L) and levofloxacin (32 mg/L and 2 mg/L). Furthermore, WQ-3810 was the most potent among the fluoroquinolones tested against meticillin-resistant Staphylococcus aureus (MRSA) and Neisseria gonorrhoeae, including FQR isolates. Group: Others. Alternative Names: KPI-10; KPI10; KPI 10; WQ3810; WQ-3810; WQ 3810. CAS No. 888032-58-4. Molecular formula: C22H22F3N5O3. Mole weight: 461.45. Appearance: Solid powder. Purity: >98%. IUPACName: 1-(6-Amino-3,5-difluoropyridin-2-yl)-6-fluoro-7-(3-(isopropylamino)azetidin-1-yl)-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid. Canonical SMILES: O=C (C1=CN (C2=NC (N)=C (F)C=C2F)C3=C (C=C (F)C (N4CC (NC (C)C)C4)=C3C)C1=O)O. Catalog: ACM888032584. |  |
| KPM-2 | KPM-2 is an inhibitor of sirtuin-2 (SIRT2), an NAD-dependent protein deacetylase, which is thought to be involved in cancer progression and in neurodegeneration. It shows antiproliferative activity in cancer cells and inhibits neurite growth. KMP-2 is hopefully used for the treatment of cancer progression and neurodegenerative disorders. Uses: The potential treatment of cancer. Synonyms: KPM-2; KPM 2; KPM2. |  |
| Kpn I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 20-fold overdigestion with enzyme more than 90% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 2000U; 10000U. GGTAC↑C C↓CATGG. Activity: 20000u.a./ml. Appearance: 10 X SE-buffer B, BSA. Storage: -20°C. Form: Liquid. Source: An E.coli strain that carries the cloned Kpn I gene from Klebsiella pneumonia. Pack: 10 mM Tris-HCl(pH 7.5); 50 mM NaCl; 0,1 mM EDTA; 1 mM DTT; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1125RE. |  |
| KPT185 | KPT185. Group: Biochemicals. Alternative Names: (2Z) -3-[3-[3-Methoxy-5- (trifluoromethyl) phenyl]-1H-1, 2, 4-triazol-1-yl]-2-Propenoic Acid 1-Methylethyl Ester. Grades: Highly Purified. CAS No. 1333151-73-7. Pack Sizes: 10mg. Molecular Formula: C16H16F3N3O3, Molecular Weight: 355.31. US Biological Life Sciences. |  Worldwide |
| KPT-185 | KPT-185 is an orally bioavailable and selective inhibitor of CRM1 and displays potent antiproliferative properties at submicromolar concentrations ( IC 50 =100-500 nM), induces apoptosis, cell-cycle arrest, and myeloid differentiation in AML cell lines and patient blasts [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1333151-73-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15611. |  |
| KPT 251 | KPT 251. Group: Biochemicals. Alternative Names: (Z) -2- (2- (3- (3, 5-Bis (trifluoromethyl) phenyl) -1H-1, 2, 4-triazol-1-yl) vinyl) -1, 3, 4-oxadiazole. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Kpt-330, (E)- | Cas No. 1421923-86-5. | |
| KPT 330 Hydrochloride | KPT 330 Hydrochloride, is a chromosome maintenance protein 1 (CRM1) inhibitor. KPT 330 suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C17H11F6N7O; HCl, Molecular Weight: 443.313646. US Biological Life Sciences. | Worldwide |
| KPT9274 | KPT9274 Inhibitor. Uses: Scientific use. Product Category: T4354. CAS No. 1643913-93-2. |  |
| KPU-300 | KPU-300, a diketopiperazine derivative, has been found to be an antimicrotubule agent and exhibit cytotoxicity against HT-29 cells. IC50: 7.0 nM. Synonyms: KPU-300; KPU 300; KPU300; (E)-3-((E)-3-benzoylbenzylidene)-6-(pyridin-2-ylmethylene)piperazine-2,5-dione. Grades: 98%. CAS No. 1620692-60-5. Molecular formula: C24H17N3O3. Mole weight: 395.42. | |
| KR-12 | KR-12 is an antibacterial peptide. It has activity against gram-positive bacteria and gram-negative bacteria. Synonyms: KR-12 (human); Antibacterial Protein LL-37 amide (human) (18-29); H-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-NH2. Grades: 95.6%. CAS No. 1218951-51-9. Molecular formula: C71H127N25O15. Mole weight: 1570.9. | |
| KR30031 | KR30031 is a novel P-glycoprotein inhibitor with potential anticancer activity. KR30031 is a verapamil analog with fewer cardiovascular effects. The ability of KR-30031 to reduce this efflux transport is equal to that of verapamil, a well-known P-glycoprotein inhibitor. The bioavailability of paclitaxel could be enhanced by coadministration of a P-glycoprotein inhibitor, KR-30031. Synonyms: KR-30031; KR 30031; 1- (3- ( (3, 4-dimethoxyphenethyl) (methyl)amino)propyl)-4, 5-dimethoxy-2, 3-dihydro-1H-indene-1-carbonitrile. Grades: 98%. CAS No. 205535-74-6. Molecular formula: C26H34N2O4. Mole weight: 438.56. | |
| KR-32568 | KR-32568 is a sodium-hydrogen exchanger isoform-1 (NHE-1) inhibitor (IC50 = 230 nM). KR-32568 inhibited NHE-1-mediated rabbit platelet swelling induced by intracellular acidification. It reduced myocardial infarct size in an anesthetized rat model. Synonyms: [5-(2-Methyl-5-fluorophenyl)furan-2-ylcarbonyl]guanidine. Grades: ≥98%. CAS No. 852146-73-7. Molecular formula: C13H12FN3O2. Mole weight: 261.3. | |
| Kras4B G12D-IN-1 | Kras4B G12D-IN-1 is a Kras4B G12D inhibitor with anticancer effects. Kras4B G12D-IN-1 decreases Kras protein expression in mouse embryonic fibroblasts (MEF) expressing Kras4B G12D (WO2016179558A1, Comp 994566) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2042365-85-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153413. | |
| K-Ras G12C-IN-1 | K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C extracted from patent WO 2014152588 A1. Uses: Scientific research. Group: Signaling pathways. CAS No. 1629265-17-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18604. | |
| K-Ras G12C-IN-1 | K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C. Synonyms: K-Ras G12C-IN-1. Grades: >98%. CAS No. 1629265-17-3. Molecular formula: C22H23Cl2N3O3. Mole weight: 448.34. | |
| K-Ras G12C-IN-2 | K-Ras G12C-IN-2 is a novel and irreversible inhibitor of mutant K-ras G12C. Synonyms: K-Ras G12C-IN-2. Grades: >98%. CAS No. 1629267-75-9. Molecular formula: C21H27ClN4O3. Mole weight: 418.92. | |
| K-Ras G12C-IN-3 | K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C. Synonyms: K-Ras G12C-IN-3. Grades: >98%. CAS No. 1629268-19-4. Molecular formula: C21H19Cl3N2O3. Mole weight: 453.75. | |
| K-Ras G12C-IN-4 | K-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRAS G12C [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2376328-55-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128771. | |
| K-Ras(G12C) inhibitor 12 | K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C). Synonyms: MDK-7958; MDK7958; MDK 7958; K-Ras(G12C) inhibitor 12. Grades: >98%. CAS No. 1469337-95-8. Molecular formula: C15H17ClIN3O3. Mole weight: 449.67. | |
| K-Ras(G12C) inhibitor 12 | K-Ras(G12C) inhibitor 12 is a K-Ras(G12C) inhibitor. K-Ras(G12C) inhibitor 12 acts on H1792 cells with an EC50 of 0.32 μM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1469337-95-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18707. | |
| KRAS G12C inhibitor 14 | KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 17, has an IC 50 of 18 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2349393-95-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125872. | |
| K-Ras(G12C) inhibitor 6 | K-Ras(G12C) inhibitor 6 is an irreversible, allosteric inhibitor of the K-Ras(G12C) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2060530-16-5. Pack Sizes: 2 mg. Product ID: HY-107841. | |
| K-Ras(G12C) inhibitor 9 | K-Ras (G12C) inhibitor 9 is an allosteric inhibitor of the K-Ras (G12C) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1469337-91-4. Pack Sizes: 2 mg. Product ID: HY-12446. | |
| K-Ras(G12C) inhibitor 9 | K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C). Synonyms: K-RAS inhibitor 9; N-(1-{2-[(4-chloro-5-iodo-2-methoxyphenyl)amino]acetyl}piperidin-4-yl)ethene-1-sulfonamide. Grades: >98%. CAS No. 1469337-91-4. Molecular formula: C16H21ClIN3O4S. Mole weight: 513.78. | |
| K-Ras-IN-1 | K-Ras-IN-1 is a K-Ras inhibitor. It binds to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure. Synonyms: MDK-3017; MDK3017; MDK 3017; K-Ras-IN-2; K-Ras Inhibitor-2. 1-(2-Hydroxythiobenzoyl)pyrrolidine;6-[pyrrolidin-1-yl(sulfanyl)methylidene]cyclohexa-2,4-dien-1-one. Grades: >98%. CAS No. 84783-01-7. Molecular formula: C11H13NOS. Mole weight: 207.29. | |
| KRC-108 | KRC-108 is a multiple kinase inhibitor. KRC-108 is a potent inhibitor of Ron, Flt3 and TrkA as well as c-Met. KRC-108 inhibited oncogenic c-Met M1250T and Y1230D more strongly than wild type c-Met. The anti-proliferative activity of KRC-108 was measured by performing a cytotoxicity assay on a panel of cancer cell lines. The GI(50) values (i.e., 50% inhibition of cell growth) for KRC-108 ranged from 0.01 to 4.22 μM for these cancer cell lines. KRC-108 was also effective for the inhibition of tumor growth in human HT29 colorectal cancer and NCI-H441 lung cancer xenograft models in athymic BALB/c nu/nu mice. This molecule should serve as a useful lead for inhibitors targeting kinases and may lead to new therapeutics for the treatment of cancer. Synonyms: KRC 108; KRC108; 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine. CAS No. 1146944-35-5. Molecular formula: C20H20N6O. Mole weight: 360.41. | |
| KRCA 0008 | KRCA 0008. Group: Biochemicals. Grades: Purified. CAS No. 1472795-20-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| KRCA-0008 | Potent and selective dual ALK (anaplastic lymphoma kinase ) and ACK1 inhibitor (IC50 values 12 nM and 4 nM for ALK and Ack1, respectively) with good drug-like properties: good water-solubility with moderate plasma protein binding and low brain exposure. It has good liver microsomal stability and little to no CYP inhibition. KRCA0008 also shows promising pharmacokinetic parameters in both mice and rat (oral bioavailability=66-94.5%) and a modest tumor growth inhibition in vivo activity in H3122 human lung cancer bearing mice model comparable to Crizotinib without significant body weight change. Synonyms: KRCA-0008; KRCA 0008; KRCA0008. Grades: >98%. CAS No. 1472795-20-2. Molecular formula: C30H37ClN8O4. Mole weight: 609.12. | |
| Kresoxim-methyl | Kresoxim-methyl (BAS 490 F), a Strobilurin-based fungicide, inhibits the respiration at the complex III (cytochrome bc1 complex). Kresoxim-methyl binds to complex III from yeast with an apparent K d of 0.07 μM proving a high affinity for this enzyme [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAS 490 F. CAS No. 143390-89-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-125776. | |
| Kresoxim-methyl | An agricultural fungicide. Group: Biochemicals. Alternative Names: (α E) -α - (methoxyimino) -2-[ (2-methylphenoxy) methyl]benzeneacetic acid methyl ester; BAS 490-02F; BAS 490F; Candit; Cygnus; Discus; Discus (fungicide); RIL-FA 200; Strob 1; Stroby; Stroby WG. Grades: Highly Purified. CAS No. 143390-89-0. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Kresoxim-methyl-d7 | Kresoxim-methyl-d7. Group: Biochemicals. Alternative Names: (α E) -α - (methoxyimino) -2-[ (2-methylphenoxy) methyl]benzeneacetic Acid Methyl Ester-d7; BAS 490-02F-d7; BAS 490F-d7; Candit-d7; Cygnus-d7; Discus-d7; Discus (fungicide)-d7; RIL-FA 200-d7; Strob 1-d7; Stroby-d7; Stroby WG-d7. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C18H12D7NO4, Molecular Weight: 320.39. US Biological Life Sciences. | Worldwide |
| Kresoxim-methyl Impurity 1 | Kresoxim-methyl Impurity 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 181373-11-5. Molecular Formula: C17H17NO5. Mole Weight: 315.3. Catalog: APB181373115. |  |
| Kresoxim-methyl Impurity 2 | Kresoxim-methyl Impurity 2. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1639810-41-5. Molecular Formula: C17H17NO5. Mole Weight: 315.33. Catalog: APB1639810415. | |
| Kresoxim-methyl Impurity 3 | Kresoxim-methyl Impurity 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 913614-77-4. Molecular Formula: C18H19NO4. Mole Weight: 313.15. Catalog: APB913614774. | |
| Kresoxim-methyl Impurity 4 | Kresoxim-methyl Impurity 4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 141517-21-7. Molecular Formula: C20H19F3N2O4. Mole Weight: 408.38. Catalog: APB141517217. | |
| Kresoxim-methyl Impurity 5 | Kresoxim-methyl Impurity 5. Uses: For analytical and research use. Group: Impurity standards. CAS No. 149961-52-4. Molecular Formula: C19H22N2O3. Mole Weight: 326.39. Catalog: APB149961524. | |
| Kreysigine | (-)-Kreysigine is an alkaloid originally isolated from B. vernum. Synonyms: (-)-Kreysigine. Grades: >95% by HPLC. CAS No. 23117-57-9. Molecular formula: C22H27NO5. Mole weight: 385.45. | |
| KRH1636 | KRH1636 is an orally active, selective and extremely potent CXC chemokine receptor 4(CXCR4) antagonist. It exhibits a potent and selective anti-HIV-1 activity. It efficiently blocked replication of various T cell line-tropic (X4) HIV type 1 (HIV-1) in MT-4 cells and peripheral blood mononuclear cells through the inhibition of viral entry and membrane fusion via the CXCR4 coreceptor. It also inhibits binding of the CXC chemokine, stromal cell-derived factor 1alpha, to CXCR4 specifically and subsequent signal transduction. It prevented monoclonal antibodies from binding to CXCR4 without down-modulation of the coreceptor. It seems to be a promising agent for the treatment of HIV-1 infection. Uses: Krh1636 seems to be a promising agent for the treatment of hiv-1 infection. Synonyms: KRH-1636; KRH 1636; KRH1636. N-[(2S)-5-(diaminomethylideneamino)-1-[[(1S)-1-naphthalen-1-ylethyl]amino]-1-oxopentan-2-yl]-4-[[methyl(pyridin-2-yl)amino]methyl]benzamide;KRH-1636;N-((S)-5-guanidino-1-(((S)-1-(naphthalen-1-yl)ethyl)amino)-1-oxopentan-2-yl)-4-(((pyridin-2-ylmethyl)amino. Grades: 98%. CAS No. 568526-77-2. Molecular formula: C32H37N7O2. Mole weight: 551.70. | |
| KRH3955 | KRH3955 is a novel CXCR4 antagonist. It is an orally bioavailable compound. It inhibits SDF-1alpha-mediated chemotaxis and HIV-1 infection. Uses: Krh3955 inhibits sdf-1alpha-mediated chemotaxis and hiv-1 infection. Synonyms: KRH-3955; KRH 3955; KRH3955; KRH3955 Salt;N1-(4-((((1H-imidazol-2-yl)methyl)((1-methyl-1H-imidazol-2-yl)methyl)amino)methyl)benzyl)-N1-methyl-N4,N4-dipropylbutane-1,4-diamine tris((2R,3R)-2,3-dihydroxysuccinate);2,3-Dihydroxybutanedioic acid N-[[4-[[1H-imidazol-2-ylmethyl-[ (1-methylimidazol-2-yl) methyl]amino]methyl]phenyl]methyl]-N-methyl-N', N'-dipropylbutane-1, 4-diamine. Grades: >98%. CAS No. 1097732-62-1. Molecular formula: C40H63N7O18. Mole weight: 929.97. | |
| KRIBB11 | KRIBB11. Group: Biochemicals. Grades: Purified. CAS No. 342639-96-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| KRIBB11 | KRIBB11 is a heat shock factor (HSF) inhibitor (IC50 = 1.2 μM). KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter. In vivo, administration of KRIBB11 decreases tumor growth in a mouse HCT116 xenograft model. Synonyms: N2-(1H-indazole-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine; KRIBB11; KRIBB-11; KRIBB 11. CAS No. 342639-96-7. Molecular formula: C13H12N6O2. Mole weight: 284.27. | |
| KRIBB3 | KRIBB3 is novel and potent microtubule inhibitor with potential anticancer activity. KRIBB3 has anti-migratory and anti-invasive activities in MDA-MB-231 cells. KRIBB3 inhibits tumor cell migration and invasion by blocking protein kinase C-dependent phosphorylation of Hsp27 through its direct binding to Hsp27. Synonyms: KRIBB-3; KRIBB 3; (6Z)-4-ethyl-3-methoxy-6-[4-(4-methoxyphenyl)-2H-1,2-oxazol-5-ylidene]cyclohexa-2,4-dien-1-one. Grades: 98%. CAS No. 129414-88-6. Molecular formula: C19H19NO4. Mole weight: 325.36. | |
| KRN383 | KRN383 is a novel Flt3 inhibitor with potential anticancer activity. KRN383 inhibited the autophosphorylation of Flt3 bearing internal tandem duplications (ITDs) and the Asp835Tyr (D835Y) point mutation with half-maximal inhibitory concentration (IC(50)) values of < or =5.9 and 43 nM, respectively. KRN383 also inhibited the proliferation of the ITD-positive cell lines with IC(50) values of < or =2.9 nM. A single oral administration of 80 mg/kg of KRN383 eradicated ITD-positive xenograft tumors in nude mice and prolonged the survival of SCID mice carrying ITD-positive AML cells. The effectiveness of a single oral dose of KRN383 suggests that it has the potential to be used in a wide variety of clinical regimens, including multicycle and combination therapies. Synonyms: KRN 383; KRN-383. CAS No. 919767-02-5. Molecular formula: C17H17N3O4. Mole weight: 327.34. | |
| KRN4884 | KRN4884, a synthesized 3-pyridine derivative, shows a long-lasting antihypertensive effect based on its potent potassium channel-opening action. The long-lasting action may be due to a slow association/dissociation with/from the binding sites on vascular smooth muscle. Synonyms: 5-amino-N'-[2-(2-chlorophenyl)ethyl]-N-cyanopyridine-3-carboximidamide; 5-amino-N-(2-(2-chlorophenyl)ethyl)-N'-cyano-3-pyridinecarboxamidine; KRN 4884; KRN-4884; KRN4884. CAS No. 152802-84-1. Molecular formula: C15H14ClN5. Mole weight: 299.76. | |
| KRN5500 | KRN5500 is a semisynthetic derivative of the nucleoside-like antineoplastic antibiotic spicamycin, originally isolated from the bacterium Streptomyces alanosinicus. KRN 5500 inhibits protein synthesis by interfering with endoplasmic reticulum and Golgi apparatus functions. This agent also induces cell differentiation and caspase-dependent apoptosis. Synonyms: KRN-5500; KRN 5500; SPK-241; SPK241; SPK 241; NSC-650426; 4-Deoxy-N- (7H-purin-6-yl) -4- ( ( (2, 4-tetradecadienoylamino) acetyl) amino) heptopyranosylamine. CAS No. 151276-95-8. Molecular formula: C28H43N7O7. Mole weight: 589.69. | |
| KRN633 | KRN633 is a potent and selective VEGFR inhibitor. which inhibits tyrosine phosphorylation of VEGFR-2 (IC50 = 1.16 nmol/L) in human umbilical vein endothelial cells. Selectivity profiling with recombinant tyrosine kinases showed that KRN633 is highly selective for VEGFR-1, -2, and -3. KRN633 inhibits tumor growth in several in vivo tumor xenograft models with diverse tissue origins, including lung, colon, and prostate, in athymic mice and rats. KRN633 also causes the regression of some well-established tumors and those that had regrown after the cessation of treatment. KRN633 was well tolerated and had no significant effects on body weight or the general health of the animals. KRN633 might be useful in the treatment of solid tumors and other diseases that depend on pathologic angiogenesis. Synonyms: KRN633; KRN-633; KRN 633. Grades: 0.98. CAS No. 286370-15-8. Molecular formula: C20H21ClN4O4. Mole weight: 416.86. | |
| KRN7000 | KRN7000 is a synthetic analog of α-galactosylceramide and the marine natural product agelasphin. It is a specific ligand for human and mouse NKT cells and remains the best studied ligand of the lipid-binding MHC class I-like protein CD1d. It protects against LPS-induced shock and displays potent antitumor activity in various in vivo models. Synonyms: a-Gal-Cer N-[(1S,2S,3R)-1-[(a-D-Galactopyranosyloxy)methyl]-2,3-dihydroxyheptadecyl]hexacosanamide KRN7000. Grades: >99%. CAS No. 158021-47-7. Molecular formula: C50H99NO9. Mole weight: 858.32. | |
| Kroll's Reagent | Excellent for titanium and alloys. Group: Etchants. |  |
| KRP-203 | KRP-203. Group: Biochemicals. Alternative Names: 2-Amino-2- [2- [2-chloro-4- [ [3- (phenylmethoxy) phenyl] thio] phenyl] ethyl] -1, 3-propanediol hydrochloride. Grades: Highly Purified. CAS No. 509088-69-1. Pack Sizes: 50mg, 100mg. Molecular Formula: C24H27Cl2NO3S. US Biological Life Sciences. | Worldwide |
| KRP-203 | KRP-203 is a selective Sphingosine-1-phosphate receptor agonist that has been shown to reduce peripheral lymphocyte infiltration and to prolong survival in rat transplant models. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in many critical cellular processes including proliferation, survival, and migration, as well as angiogenesis and immune responses. Activation of sphingosine kinase by a variety of agonists increases intracellular S1P, which in turn can function intracellularly as a second messenger or be secreted out of the cell and act extracellularly by signaling through S1P (S1P1-5) receptors. The phosphorylated form of KRP 203 demonstrates a high affinity for the S1P1 receptor with an ED50 value in the nM range and an ED50 value >1 μM for the S1P3 receptor. Synonyms: Mocravimod hydrochloride; 2-Amino-2-(4-((3-(benzyloxy)phenyl)thio)-2-chlorophenethyl)propane-1,3-diol hydrochloride; 1,3-Propanediol, 2-amino-2-[2-[2-chloro-4-[[3- (phenylmethoxy) phenyl]thio]phenyl]ethyl]-, hydrochloride (1:1). Grades: ≥98%. CAS No. 509088-69-1. Molecular formula: C24H27Cl2NO3S. Mole weight: 480.45. | |
| KRP297 | KRP297, also called as L4 10198 or MK 767, is a Peroxisome proliferator-activated receptor (PPAR) alpha and gamma (PPARα and PPARγ) agonist. With potential to treat type 2 diabetes and dyslipidemia, KRP297 is able to decrease plasma glucose and insulin levels. Synonyms: 5-[ (2, 4-dioxo-1, 3-thiazolidin-5-yl) methyl]-2-methoxy-N-[[4- (trifluoromethyl) phenyl]methyl]benzamide; KCL1998001079; KRP 297; KRP-297; KRP297; L 410198; L-410198; L410198; MK 767; MK-767; MK767. Grades: >98%. CAS No. 213252-19-8. Molecular formula: C20H17F3N2O4S. Mole weight: 438.42. | |
| KRpep-2d | KRpep-2d is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research [1]. Uses: Scientific research. Group: Peptides. CAS No. 2098181-84-9. Pack Sizes: 2 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P3277. | |
| KRpep-2d | KRpep-2d is a K-Ras(G12D) selective inhibitory cyclic peptide that has the potential as the treatment of cancers expressing K-Ras(G12C) mutant. Synonyms: s8499. Molecular formula: C108H182N44O25S2. Mole weight: 2561.01. | |
| KRX-0402 | KRX-0402 (O6-benzyl guanine or O6-BG) is a small molecule that was specifically designed to block the DNA repair protein, MGMT. MGMT confers resistance to certain alkylating agents, such as temozolomide and BCNU, that are commonly used to treat brain cancer, melanoma and non-Hodgkin's lymphoma. Recent research has shown that KRX-0402 can also potentiate the activity of other alkylating agents, such as cyclophosphamide, ifosphamide, cisplatinum and carboplatinum. These drugs are some of the most widely used chemotherapy drugs and are commonly used to treat breast cancer, non-small cell lung cancer and ovarian cancer. Accordingly, It is believed that KRX-0402 may have an important role in making cells more susceptible to the damaging effects of alkylating agents, and that KRX-0402 may have utility in the treatment of multiple forms of cancer. KRX-0402 is administered intravenously. To date, approximately 400 patients have received KRX-0402 in multiple clinical studies. Dose limiting toxicity for KRX-0402 in combination with chemotherapy was bone marrow suppression. KRX-0402 alone has no identified dose limiting toxicity. Two company-sponsored, Phase II clinical trials for KRX-0402 are ongoing. Uses: Enzyme inhibitors. Synonyms: KRX 0402; KRX0402; 6-O-Benzylguanine; 6-(Benzyloxy)-7H-purin-2-amine; O(6)-Benzylguanine; 2-Amino-6-(benzyloxy)purine; NSC-637037; O6-BG. CAS No. 1000874-21-4. Molecular formula: C12H11N5O. Mole weight: 241.254. | |
| KS100 | KS100 is a potent ALDH inhibitor with IC 50 s of 230, 1542, 193 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS100 shows antiproliferative and anticancer effects with low low toxic. KS100 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS10600 induces apoptosis and cell cycle arrest at the G2/M phase [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2408477-54-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-146682. | |
| KS176 | KS176 is a breast cancer resistance protein inhibitor and also exhibits some extent of inhibition of ATP-binding cassette sub-family G member 2. IC50: 1.39 μM. Uses: Ks176 is a breast cancer resistance protein inhibitor and also exhibits some extent of inhibition of atp-binding cassette sub-family g member 2. Synonyms: KS-176; KS176; KS 176. ZINC86032128; AKOS024458013; CS-5435; HY-19753; CS 5435; HY 19753; CS5435; HY19753. Grades: 98%. CAS No. 1253452-78-6. Molecular formula: C22H19N3O5. Mole weight: 405.40. | |
| KS 176 | KS 176. Group: Biochemicals. Grades: Purified. CAS No. 1253452-78-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| KS2100 Hydrogenated rosin resin | | |
| KS370G | KS370G is an orally active hypoglycemic and cardiovascular protective agent. KS370G improves left ventricular hypertrophy and function in pressure-overload mice heart. KS370G reduces renal obstructive nephropathy [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 105955-01-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-114683. | |
| Ks 501 | Heterocyclic Organic Compound. CAS No. 120634-86-8. Catalog: ACM120634868. | |
| KS-501 | It is produced by the strain of Sporothrix sp. KAC-1989. KS-501 inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of 1.8 μmol/L. Synonyms: KS 501; 3-Heptyl-5-hydroxyphenyl 2-heptyl-6-(hexofuranosyloxy)-4-hydroxybenzoate. CAS No. 120634-86-8. Molecular formula: C33H48O10. Mole weight: 604.73. | |
| KS 502 | It is produced by the strain of Sporothrix sp. KAC-1989. KS 502 inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of 4.4 μmol/L. Synonyms: Benzoic acid, 2-(beta-D-galactofuranosyloxy)-6-heptyl-4-hydroxy-, 4-carboxy-3-heptyl-5-hydroxyphenyl ester. Grades: >98%. CAS No. 120634-85-7. Molecular formula: C34H48O12. Mole weight: 648.74. | |
| KS 504a | It is produced by the strain of Mollisia ventosa KAC-1148. KS 504a inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of 122 μmol/L. Synonyms: KS-504a; KS-504b; BRN 4354490; 1-Oxaspiro(2.4)heptan-5-ol, 2,4,4,6,6-pentachloro-7-(dichloromethylene)-. CAS No. 122022-77-9. Molecular formula: C7H3Cl7O2. Mole weight: 367.27. | |
| KS-504d | It is produced by the strain of Mollisia ventosa KAC-1148. KS-504d inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of >500 μmol/L. Synonyms: KS 504d; BRN 4322179; (+)-1-(Dichloromethyl)-5-(dichloromethylene)-2,2,4,4-tetrachloro-1,3-cyclopentanediol. CAS No. 122005-23-6. Molecular formula: C7H4Cl8O2. Mole weight: 403.73. | |
| KS-504e | It is produced by the strain of Mollisia ventosa KAC-1148. KS-504e inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of 139 μmol/L. Synonyms: KS 504e; BRN 4321107; (+)-4-Hydroxy-3,3,5,5-tetrachloro-2-(trichloromethyl)-1-cyclopentene-1-carboxaldehyde; 1-Cyclopentene-1-carboxaldehyde, 3,3,5,5-tetrachloro-4-hydroxy-2-(trichloromethyl)-, (+)-. CAS No. 122006-32-0. Molecular formula: C7H3Cl7O2. Mole weight: 367.27. | |
| KS-619-1 | It is produced by the strain of Streptomyces californicus KS-619-1. KS-619-1 inhibited Ca2+ and CAM-PDE in bovine brain and heart with an IC50 of 2.0 and 1.5 μmol/L. Synonyms: KS 619-1; Benzo(a)naphthacene-2-carboxylic acid, 5,6,8,13-tetrahydro-1,7,9,11-tetrahydroxy-8,13-dioxo-3-(2-oxopropyl)-. CAS No. 103370-21-4. Molecular formula: C26H18O9. Mole weight: 474.41. | |
| Ksp22 I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 20-fold overdigestion with enzyme more than 90% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 1000U; 5000U. T↑GATCA ACTAG↓T. Activity: 20000u.a./ml. Appearance: 10 X SE-buffer 2K, BSA. Storage: -20°C. Form: Liquid. Source: Kurthia species 22. Pack: 10 mM Tris-HCl (pH 7.5); 250 mM NaCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA, 50% glycerol. Cat No: ET-1126RE. | |
| KSPWFTTL | KSPWFTTL is an immunodominant Kb-restricted epitope from the p15E transmembrane protein. KSPWFTTL can restore susceptibility of a tumor line to anti-AKR/Gross MuLV cytotoxic T lymphocytes [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 153049-05-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P3333. | |
| KSQ-4279 | KSQ-4279 is a USP1 and PARP inhibitor. KSQ-4279 showed anti-proliferative effects in a subset of cell lines, often characterized by the presence of homologous recombination deficiencies (HRD), including mutations in BRCA1/2. The combination of KSQ-4279 with olaparib was able to induce strong and durable regressions across a number of ovarian and TNBC PDX models. Group: Inhibitors. Alternative Names: KSQ-4279; KSQ 4279; KSQ4279. CAS No. 2446480-97-1. Molecular formula: C27H25F3N8O. Mole weight: 534.55. Appearance: Solid powder. Purity: >98%. IUPACName: 1H-Pyrazolo[3,4-d]pyrimidine, 6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]-. Canonical SMILES: FC (C1=CN (C (C)C)C (C2=CC=C (CN3N=CC4=CN=C (C5=C (OC)N=CN=C5C6CC6)N=C43)C=C2)=N1) (F)F. Catalog: ACM2446480971. | |
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