American Chemical Suppliers
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Product | Description | |
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KRN7000 Quick inquiry Where to buy Suppliers range | KRN7000. Uses: For analytical and research use. Group: Building Blocks. CAS No. 158021-47-7. IUPAC Name: N-[(2S,3S,4R)-3,4-dihydroxy-1-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadecan-2-yl]hexacosanamide. Molecular formula: C50H99NO9. Mole weight: 858.32. Catalog: APS158021477. SMILES: CCCCCCCCCCCCCCCCCCCCCCCCCC (=O)N[C@@H] (CO[C@H]1O[C@H] (CO)[C@H] (O)[C@H] (O)[C@H]1O)[C@H] (O)[C@H] (O)CCCCCCCCCCCCCC. Format: Neat. | |
KRN7000 Quick inquiry Where to buy Suppliers range | KRN7000 is a synthetic analog of α-galactosylceramide and the marine natural product agelasphin. It is a specific ligand for human and mouse NKT cells and remains the best studied ligand of the lipid-binding MHC class I-like protein CD1d. It protects against LPS-induced shock and displays potent antitumor activity in various in vivo models. Synonyms: a-Gal-Cer N-[(1S,2S,3R)-1-[(a-D-Galactopyranosyloxy)methyl]-2,3-dihydroxyheptadecyl]hexacosanamide KRN7000. Grades: >99%. CAS No. 158021-47-7. Molecular formula: C50H99NO9. Mole weight: 858.32. | |
KRP-203 Quick inquiry Where to buy Suppliers range | KRP-203 is a selective Sphingosine-1-phosphate receptor agonist that has been shown to reduce peripheral lymphocyte infiltration and to prolong survival in rat transplant models. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in many critical cellular processes including proliferation, survival, and migration, as well as angiogenesis and immune responses. Activation of sphingosine kinase by a variety of agonists increases intracellular S1P, which in turn can function intracellularly as a second messenger or be secreted out of the cell and act extracellularly by signaling through S1P (S1P1-5) receptors. The phosphorylated form of KRP 203 demonstrates a high affinity for the S1P1 receptor with an ED50 value in the nM range and an ED50 value >1 μM for the S1P3 receptor. Synonyms: Mocravimod hydrochloride; 2-Amino-2-(4-((3-(benzyloxy)phenyl)thio)-2-chlorophenethyl)propane-1,3-diol hydrochloride; 1,3-Propanediol, 2-amino-2-[2-[2-chloro-4-[[3- (phenylmethoxy) phenyl]thio]phenyl]ethyl]-, hydrochloride (1:1). Grades: ≥98%. CAS No. 509088-69-1. Molecular formula: C24H27Cl2NO3S. Mole weight: 480.45. | |
KRP-203 Quick inquiry Where to buy Suppliers range | KRP-203. Group: Biochemicals. Alternative Names: 2-Amino-2- [2- [2-chloro-4- [ [3- (phenylmethoxy) phenyl] thio] phenyl] ethyl] -1, 3-propanediol hydrochloride. Grades: Highly Purified. CAS No. 509088-69-1. Pack Sizes: 50mg, 100mg. Molecular Formula: C24H27Cl2NO3S. US Biological Life Sciences. | Worldwide |
KRP297 Quick inquiry Where to buy Suppliers range | KRP297, also called as L4 10198 or MK 767, is a Peroxisome proliferator-activated receptor (PPAR) alpha and gamma (PPARα and PPARγ) agonist. With potential to treat type 2 diabetes and dyslipidemia, KRP297 is able to decrease plasma glucose and insulin levels. Synonyms: 5-[ (2, 4-dioxo-1, 3-thiazolidin-5-yl) methyl]-2-methoxy-N-[[4- (trifluoromethyl) phenyl]methyl]benzamide; KCL1998001079; KRP 297; KRP-297; KRP297; L 410198; L-410198; L410198; MK 767; MK-767; MK767. Grades: >98%. CAS No. 213252-19-8. Molecular formula: C20H17F3N2O4S. Mole weight: 438.42. | |
KRpep-2d Quick inquiry Where to buy Suppliers range | KRpep-2d is a K-Ras(G12D) selective inhibitory cyclic peptide with selectivity against wild-type (WT) K-Ras and the K-Ras(G12C) mutant. The IC50 value is 1.6 nM. Uses: Peptide Inhibitors. Product ID: R1941. | |
KRpep-2d Quick inquiry Where to buy Suppliers range | KRpep-2d is a K-Ras(G12D) selective inhibitory cyclic peptide that has the potential as the treatment of cancers expressing K-Ras(G12C) mutant. Synonyms: s8499. Molecular formula: C108H182N44O25S2. Mole weight: 2561.01. | |
KRX-0402 Quick inquiry Where to buy Suppliers range | KRX-0402 (O6-benzyl guanine or O6-BG) is a small molecule that was specifically designed to block the DNA repair protein, MGMT. MGMT confers resistance to certain alkylating agents, such as temozolomide and BCNU, that are commonly used to treat brain cancer, melanoma and non-Hodgkin's lymphoma. Recent research has shown that KRX-0402 can also potentiate the activity of other alkylating agents, such as cyclophosphamide, ifosphamide, cisplatinum and carboplatinum. These drugs are some of the most widely used chemotherapy drugs and are commonly used to treat breast cancer, non-small cell lung cancer and ovarian cancer. Accordingly, It is believed that KRX-0402 may have an important role in making cells more susceptible to the damaging effects of alkylating agents, and that KRX-0402 may have utility in the treatment of multiple forms of cancer. KRX-0402 is administered intravenously. To date, approximately 400 patients have received KRX-0402 in multiple clinical studies. Dose limiting toxicity for KRX-0402 in combination with chemotherapy was bone marrow suppression. KRX-0402 alone has no identified dose limiting toxicity. Two company-sponsored, Phase II clinical trials for KRX-0402 are ongoing. Uses: Enzyme inhibitors. Synonyms: KRX 0402; KRX0402; 6-O-Benzylguanine; 6-(Benzyloxy)-7H-purin-2-amine; O(6)-Benzylguanine; 2-Amino-6-(benzyloxy)purine; NSC-637037; O6-BG. CAS No. 1000874-21-4. Molecular formula: C12H11N5O. Mole weight: 241.254. | |
Kryptofix 111 Quick inquiry Where to buy Suppliers range | Kryptofix 111. Group: Heterocyclic Organic Compound. Alternative Names: KRYPTOFIX(R) 111;KRYPTOFIX 111;4,10,15-TRIOXA-1,7-DIAZABICYCLO-[5,5,5]HEPTADECANE;KRYPTOFIX 111 99+%. CAS No. 37095-49-1. Molecular formula: C12H24N2O3. Mole weight: 244.33. | |
Kryptofix 222 Quick inquiry Where to buy Suppliers range | Kryptofix 222. Group: Heterocyclic Organic Compound. Alternative Names: 2, 2, 2-CRYPT; 2, 2, 2-CRYPTAND; 2, 2, 2-CRYPTATE; 4, 7, 13, 16, 21, 24-HEXAOXA-1, 10-DIAZABICYCLO[8.8.8]HEXACOSANE; KRYPTAND 222;KRYPTOFIX 222;KRYPTOFIX(R) 222;CRYPTOFIX 222. CAS No. 23978-09-8. Molecular formula: C18H36N2O6. Mole weight: 376.49. Symbol: GHS07. Melting Point: 68-71°C(lit.). Safty Description: 26-36-36/37/39. Hazard statements: Xi, Xn. Supplemental Hazard Statements: H315-H319-H335. | |
Kryptofix(R)211 Quick inquiry Where to buy Suppliers range | Kryptofix(R)211. Group: Heterocyclic Organic Compound. Alternative Names: 4, 7, 13, 18-TETRAOXA-1, 10-DIAZABICYCLO[8.5.5]EICOSANE; KRYPTOFIX 211;KRYPTOFIX(R) 211;4,7,13,18-tetraoxa-1,10-diazabicyclo[8.5.5]icosane;KRYPTOFIX 211 95+%;cryptating agent 211;[2.1.1]Cryptand;4,10-(Ethylenebisoxybisethylene)-1,7-dioxa-4,10-diazacyclododecane. CAS No. 31250-06-3. Molecular formula: C14H28N2O4. Mole weight: 288.38. Boiling Point: 130°C0.002mm Hg(lit.). Flash Point: >230°F. Density: 1.097g/mL at 25°C(lit.). Safty Description: 23-26-28-37/39. Hazard statements: Xn. | |
Kryptofix(R)221 Quick inquiry Where to buy Suppliers range | Kryptofix(R)221. Group: Heterocyclic Organic Compound. Alternative Names: KRYPTOFIX 221;KRYPTOFIX(R) 221;4, 7, 13, 16, 21-PENTAOXA-1, 10-DIAZABICYCLO[8.8.5]TRICOSANE;4, 7, 16, 21-Pentaoxa-1, 10-diazabicyclo[8.8.5.]tricosane;4, 7, 13, 16, 21-pentaoxa-1, 10-*diazabicyclo(8.8.5)tr;4, 7, 13, 16, 21-pentaoxa-1, 10-diazabicylco-(8.8.5)tricosane;4, 7, 13, 16, 21-PENTAOXA-1, 10-*DIAZABICYCLO (8.8.5)TRIC;KRYPTOFIX 221 98+%. CAS No. 31364-42-8. Molecular formula: C16H32N2O5. Mole weight: 332.44. Symbol: GHS07. Flash Point: >230°F. Density: 1.111g/mL at 20°C(lit.). Safty Description: 23-24/25. Supplemental Hazard Statements: H315-H319-H335. | |
KS 176 Quick inquiry Where to buy Suppliers range | KS 176. Group: Biochemicals. Grades: Purified. CAS No. 1253452-78-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
KS176 Quick inquiry Where to buy Suppliers range | KS176 is a breast cancer resistance protein inhibitor and also exhibits some extent of inhibition of ATP-binding cassette sub-family G member 2. IC50: 1.39 μM. Uses: Ks176 is a breast cancer resistance protein inhibitor and also exhibits some extent of inhibition of atp-binding cassette sub-family g member 2. Synonyms: KS-176; KS176; KS 176. ZINC86032128; AKOS024458013; CS-5435; HY-19753; CS 5435; HY 19753; CS5435; HY19753. Grades: 98%. CAS No. 1253452-78-6. Molecular formula: C22H19N3O5. Mole weight: 405.40. | |
KS2100 Hydrogenated rosin resin Quick inquiry Where to buy Suppliers range | ||
KS 370G Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 105955-01-9. Pack Sizes: 5MG, 25MG. Mole weight: 283.32. Catalog: AP105955019. Assay: ≥98% (HPLC). | |
KS-501 Quick inquiry Where to buy Suppliers range | It is produced by the strain of Sporothrix sp. KAC-1989. KS-501 inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of 1.8 μmol/L. Synonyms: KS 501; 3-Heptyl-5-hydroxyphenyl 2-heptyl-6-(hexofuranosyloxy)-4-hydroxybenzoate. CAS No. 120634-86-8. Molecular formula: C33H48O10. Mole weight: 604.73. | |
KS 502 Quick inquiry Where to buy Suppliers range | It is produced by the strain of Sporothrix sp. KAC-1989. KS 502 inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of 4.4 μmol/L. Synonyms: Benzoic acid, 2-(beta-D-galactofuranosyloxy)-6-heptyl-4-hydroxy-, 4-carboxy-3-heptyl-5-hydroxyphenyl ester. Grades: >98%. CAS No. 120634-85-7. Molecular formula: C34H48O12. Mole weight: 648.74. | |
KS 504a Quick inquiry Where to buy Suppliers range | It is produced by the strain of Mollisia ventosa KAC-1148. KS 504a inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of 122 μmol/L. Synonyms: KS-504a; KS-504b; BRN 4354490; 1-Oxaspiro(2.4)heptan-5-ol, 2,4,4,6,6-pentachloro-7-(dichloromethylene)-. CAS No. 122022-77-9. Molecular formula: C7H3Cl7O2. Mole weight: 367.27. | |
KS-504d Quick inquiry Where to buy Suppliers range | It is produced by the strain of Mollisia ventosa KAC-1148. KS-504d inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of >500 μmol/L. Synonyms: KS 504d; BRN 4322179; (+)-1-(Dichloromethyl)-5-(dichloromethylene)-2,2,4,4-tetrachloro-1,3-cyclopentanediol. CAS No. 122005-23-6. Molecular formula: C7H4Cl8O2. Mole weight: 403.73. | |
KS-504e Quick inquiry Where to buy Suppliers range | It is produced by the strain of Mollisia ventosa KAC-1148. KS-504e inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of 139 μmol/L. Synonyms: KS 504e; BRN 4321107; (+)-4-Hydroxy-3,3,5,5-tetrachloro-2-(trichloromethyl)-1-cyclopentene-1-carboxaldehyde; 1-Cyclopentene-1-carboxaldehyde, 3,3,5,5-tetrachloro-4-hydroxy-2-(trichloromethyl)-, (+)-. CAS No. 122006-32-0. Molecular formula: C7H3Cl7O2. Mole weight: 367.27. | |
KS-619-1 Quick inquiry Where to buy Suppliers range | It is produced by the strain of Streptomyces californicus KS-619-1. KS-619-1 inhibited Ca2+ and CAM-PDE in bovine brain and heart with an IC50 of 2.0 and 1.5 μmol/L. Synonyms: KS 619-1; Benzo(a)naphthacene-2-carboxylic acid, 5,6,8,13-tetrahydro-1,7,9,11-tetrahydroxy-8,13-dioxo-3-(2-oxopropyl)-. CAS No. 103370-21-4. Molecular formula: C26H18O9. Mole weight: 474.41. | |
KT109 Quick inquiry Where to buy Suppliers range | KT109 is a selective and irreversible inhibitor of DAGLβ with an IC50 value of 42 nM. Inhibition of DAGLβ by KT109 reduced the LPS-induced allodynia in the LPS model of inflammatory pain. Synonyms: (4-([1,1'-Biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl)(2-benzylpiperidin-1-yl)methanone. Grades: ≥98%. CAS No. 1402612-55-8. Molecular formula: C27H26N4O. Mole weight: 422.5. | |
KT182 Quick inquiry Where to buy Suppliers range | KT182 is a potent inhibitor of α/β-hydrolase domain-containing protein 6 (ABHD6). ABHD6 is a transmembrane serine hydrolase hydrolyzing transmembrane serine hydrolase in nernous system. ABHD6 inhibition was shown to decrease seizure incidence in several mouse models of epilepsy, suggesting its potential for Dravet Syndrome treatment. Uses: Enzyme inhibitors. Synonyms: [4-[4-[3-(hydroxymethyl)phenyl]phenyl]triazol-1-yl]-(2-phenylpiperidin-1-yl)methanone. Grades: ≥98%. CAS No. 1402612-62-7. Molecular formula: C27H26N4O2. Mole weight: 438.5. | |
KT195 Quick inquiry Where to buy Suppliers range | KT195 is a selective inhibitor of α/β-hydrolase domain-containing protein 6 (ABHD6) (IC50 = 10 nM). ABHD6 is a transmembrane serine hydrolase hydrolyzing transmembrane serine hydrolase in nernous system. ABHD6 inhibition was shown to decrease seizure incidence in several mouse models of epilepsy, suggesting its potential for Dravet Syndrome treatment. Synonyms: ML-295; (4-(4'-Methoxy-[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl)(2-phenylpiperidin-1-yl)methanone. Grades: ≥98%. CAS No. 1402612-58-1. Molecular formula: C27H26N4O2. Mole weight: 438.5. | |
KT203 Quick inquiry Where to buy Suppliers range | KT203 is a potent inhibitor of α/β-hydrolase domain-containing protein 6 (ABHD6). ABHD6 is a transmembrane serine hydrolase hydrolyzing transmembrane serine hydrolase in nervous system. ABHD6 inhibition was shown to decrease seizure incidence in several mouse models of epilepsy, suggesting its potential for Dravet Syndrome treatment. Synonyms: ML-296; 3-[4-[1-(2-Benzylpiperidine-1-carbonyl)triazol-4-yl]phenyl]benzoic acid. Grades: ≥95%. CAS No. 1402612-64-9. Molecular formula: C28H26N4O3. Mole weight: 466.5. | |
KT 5720 Quick inquiry Where to buy Suppliers range | KT 5720. Group: Biochemicals. Grades: Purified. CAS No. 108068-98-0. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
KT 5720 Quick inquiry Where to buy Suppliers range | ≥98% (HPLC), powder. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 108068-98-0. Pack Sizes: 0.1MG. Mole weight: 537.61. Catalog: AP108068980-B. Assay: ≥98% (HPLC). | |
KT5720 Quick inquiry Where to buy Suppliers range | KT 5720, an anti-bacterial agent synthesized by the fungus Nocardiopsis sp, specifically blocks PKA signaling through competitive inhibition of ATP with a Ki value of 60 nM. Uses: Anti-bacterial agents. Synonyms: 2,3,9,10,11,12-hexahydro-10S-hydroxy-9-methyl-1-oxo-9R,12S-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, hexyl ester; KT 5720; KT5720; KT-5720. Grades: 98%. CAS No. 108068-98-0. Molecular formula: C32H31N3O5. Mole weight: 537.60. | |
KT 5823 Quick inquiry Where to buy Suppliers range | KT 5823. Group: Biochemicals. Grades: Purified. CAS No. 126643-37-6. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
KT5823 Quick inquiry Where to buy Suppliers range | KT 5823 is a cell-permeable, selective inhibitor of cGMP-dependent protein kinase (PKG) (Ki values are 0.23, 4 and > 10 μM for inhibition of PKG, PKC and PKA respectively). KT 5823 is often used in intact cells to assess the role of PKG in signaling, although there are cases where it poorly inhibits PKG in cells. Uses: Kt5823 induces apoptotic fragmentation of dna. Synonyms: KT 5823; KT-5823; KT5823; 2,3,9,10,11,12-hexahydro-10R-methoxy-2,9-dimethyl-1-oxo-9S,12R-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester. Grades: ≥98%. CAS No. 126643-37-6. Molecular formula: C29H25N3O5. Mole weight: 495.52. | |
KT5823 (2, 3, 9, 10, 11, 12- hexahydro- 10R- methoxy- 2, 9- dimethyl- 1- oxo- 9S, 12R- epoxy- 1H- diindolo[1, 2, 3- fg:3, 2, 1- kl]pyrrolo[3, 4- i][1, ]benzodiazocine- 10- carboxylic acid, methyl ester) Quick inquiry Where to buy Suppliers range | Cell-permeable. KT5823 is a derivative of K-252a that acts as a selective inhibitor of Protein kinase G (PKG) (Ki = 0.234um). Inhibits other kinases at much higher concentrations (Kis for PKA=4um and for MLCK=>10um). Group: Biochemicals. Grades: Highly Purified. CAS No. 126643-37-6. Pack Sizes: 50ug. US Biological Life Sciences. | Worldwide |
KT 5926 Quick inquiry Where to buy Suppliers range | KT 5926, an organic heterooctacyclic compound, selectively inhibits nerve growth factor-dependent neurite elongation. Uses: Enzyme inhibitors. Synonyms: 9-hydroxy-9-methoxycarbonyl-8-methyl-14-n-propoxy-2, 3, 9, 10-tetrahydro-8, 11-epoxy-1H, 8H, 11H-2, 7b, 11a-triazadibenzo(a, g)cycloocta[cde]trinden-1-on; KT5926; KT-5926; KT 5926. CAS No. 126643-38-7. Molecular formula: C30H27N3O6. Mole weight: 525.55. | |
K-Type, High Flow Concentric Nebulizer Quick inquiry Where to buy Suppliers range | K-Type, High Flow Concentric Nebulizer. Uses: For analytical and research use. Group: Laboratory consumables. Catalog: APS009269. | |
KU-0058684 Quick inquiry Where to buy Suppliers range | KU-0058684 is a potent PARP and DNA-PK inhibitors. Synonyms: KU0058684; KU 0058684; KU58684; KU 58684; KU-58684; 1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)phenyl)pyrrolidine-2,5-dione. Grades: 98%. CAS No. 623578-11-0. Molecular formula: C19H14FN3O3. Mole weight: 351.34. | |
KU-0058948 Quick inquiry Where to buy Suppliers range | KU-0058948. Uses: For analytical and research use. Group: Enzyme Activators, Inhibitors & Substrates. Alternative Names: KU 0058958, KU 0058948,1(2H)-Phthalazinone, 4-[[4-fluoro-3-[(hexahydro-1H-1,4-diazepin-1-yl)carbonyl]phenyl]methyl]-, 1H-1,4-Diazepine, 1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]hexahydro- (9CI), 4-[[4-Fluoro-3-[(hexahydro-1H-1,4-diazepin-1-yl)carbonyl]phenyl]methyl]-1(2H)-phthalazinone. CAS No. 763111-49-5. IUPAC Name: 4-[[3-(1,4-diazepane-1-carbonyl)-4-fluorophenyl]methyl]-2H-phthalazin-1-one. Molecular formula: C21H21FN4O2. Mole weight: 380.42. Catalog: APS763111495. SMILES: Fc1ccc (CC2=NNC (=O)c3ccccc23)cc1C (=O)N4CCCNCC4. Format: Neat. | |
KU-0058948 Quick inquiry Where to buy Suppliers range | KU-0058948 is a poly (ADP-ribose) polymerase (PARP) inhibitor. Studies show that KU-0058948 a potent agonist that activates transfected extracellular signal-regulated kinase 8 (ERK8) in cells. KU-0058948 induces cell cycle arrest and apoptosis of primary myeloid leukemic cells and myeloid leukemic cell lines in vitro. Group: Biochemicals. Alternative Names: 4- [ [4-fluoro-3- [ (hexahydro-1H-1, 4-diazepin-1-yl) carbonyl] phenyl] methyl] -1 (2H) -phthalazinone; KU 0058948; KU0058948; 1- [5- [ (3, 4-dihydro-4-oxo-1-phthalazinyl) methyl] -2-fluorobenzoyl] hexahydro-1H-1, 4-diazepine. Grades: Highly Purified. CAS No. 763111-49-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
KU 0058948 hydrochloride Quick inquiry Where to buy Suppliers range | KU 0058948 hydrochloride is a potent poly ADP-ribose polymeras (PARP) inhibitor (IC50: 3.4 nM for PARP1). In vitro, KU-0058948 activates transfected extracellular signal-regulated kinase 8 (ERK8) in cells and induces cell cycle arrest and apoptosis of primary myeloid leukemic cells thus KU-0058948 can be potentially used to treat myeloid leukemia and myelodysplastic syndromes. Uses: Potential treatment of myeloid leukemia and myelodysplastic syndromes. Synonyms: KU 0058948 hydrochloride; KU0058948 hydrochloride; KU-0058948 hydrochloride; 4-(3-(1,4-diazepane-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one hydrochloride. Grades: 99%. Molecular formula: C21H21FN4O2.HCl. Mole weight: 416.88. | |
KU 0060648 Quick inquiry Where to buy Suppliers range | Dual PI 3-K and DNA-PK inhibitor (IC50 values are <0.1, 0.5, 4 and 19 nM for PI 3-Kdelta, PI 3-Kbeta, PI 3-Kalpha and DNA-PK respectively). Inhibits proliferation of MCF7 cells in vitro and delays growth of MCF7 xenografts in mice. Also enhances CRISPR-Cas9-mediated homology- directed repair (HDR) efficiency, and attenuates nonhomologous end-joining (NHEJ). Group: Biochemicals. Alternative Names: 4-Ethyl-N-[4-[2-(4-morpholinyl)-4-o xo-4H-1-benzopyran-8-yl]-1-dibenzothienyl]-1-piper azineacetamide. Grades: Highly Purified. CAS No. 881375-00-4. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S, Molecular Weight: 582.71. US Biological Life Sciences. | Worldwide |
KU-0060648 Quick inquiry Where to buy Suppliers range | KU-0060648 is a dual inhibitor of DNA-PK (IC50=8.6 nM) and PI3Kα (IC50=4 nM), PI3Kβ (IC50=0.5 nM), PI3Kδ (IC50=0.1 nM) less inhibition of PI3Kγ with IC50 of 0.59 μM. Synonyms: KU0060648; KU 0060648; N-[4-(2-Morpholino-4-oxo-4H-1-benzopyran-8-yl)dibenzothiophene-1-yl]-4-ethylpiperazine-1-acetamide. Grades: >98%. CAS No. 881375-00-4. Molecular formula: C33H34N4O4S. Mole weight: 582.71. | |
Ku-0063794 Quick inquiry Where to buy Suppliers range | KU-0063794 is an inhibitor of both mTORC1 and mTORC2 with an IC50 of approximately 10 nM, but does not suppress the activity of 76 other protein kinases or seven lipid kinases, including Class 1 PI3Ks (phosphoinositide 3-kinases) at 1000-fold higher concentrations. KU-0063794 is cell permeant, suppresses activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK (ribosomal S6 kinase), an AGC kinase not regulated by mTOR. It also inhibited phosphorylation of the T-loop Thr308 residue of Akt phosphorylated by PDK1 (3-phosphoinositide-dependent protein kinase-1). It does not affect Thr308 phosphorylation in fibroblasts lacking essential mTORC2 subunits. KU-0063794 also suppressed cell growth and induced a G1-cell-cycle arrest. KU-0063794 will be useful in delineating the physiological roles of mTOR and may have utility in treatment of cancers in which this pathway is inappropriately activated. Uses: Differentiation. Synonyms: KU0063794; KU-0063794; KU 0063794; Ku0063794; Ku 0063794; Ku-0063794; KU63794; KU 63794; KU-63794; [5-[2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-morpholin-4-ylpyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol. Grades: 0.98. CAS No. 938440-64-3. Molecular formula: C25H31N5O4. Mole weight: 465.554. | |
KU14R Quick inquiry Where to buy Suppliers range | KU14R. Group: Biochemicals. Grades: Purified. CAS No. 189224-48-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
KU14R Quick inquiry Where to buy Suppliers range | KU14R is an antagonist of the atypical imidazoline binding site (putative I3 receptor) in isolated pancreatic islet beta cells. Synonyms: KU14R; KU-14R; KU 14R; 2-(2-ethyl-3H-1-benzofuran-2-yl)-1H-imidazole 2-(2-ethyl-2,3-dihydro-2-benzofuranyl)-2-imidazole KU 14R KU-14R KU14R. Grades: >99 %. CAS No. 189224-48-4. Molecular formula: C13H14N2O. Mole weight: 214.26. | |
KU-2285 Quick inquiry Where to buy Suppliers range | KU-2285 is a potent hypoxic cell radiosensitizer. At less than 100 mg/kg, KU-2285 sensitized SCCVII tumors more than MISO and SR-2508 by fractionated irradiation. KU-2285 entered clinical trials in late 1990s. Synonyms: KU2285; KU 2285; NSC 635446; alpha,alpha-Difluoro-N-(2-hydroxyethyl)-2-nitro-1H-imidazole-1-propionamide. CAS No. 121077-11-0. Molecular formula: C8H10F2N4O4. Mole weight: 264.19. | |
KU-55933 Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 587871-26-9. Pack Sizes: 5MG, 25MG. Mole weight: 395.49. Catalog: AP587871269. Assay: ≥98% (HPLC). | |
KU-55933 Quick inquiry Where to buy Suppliers range | KU-55933 is an ATM inhibitor, which blocks the phosphorylation of Akt induced by insulin and insulin-like growth factor I in cancer cells that exhibit abnormal Akt activity. Moreover, KU-55933 inhibits cancer cell proliferation by inducing G(1) cell cycle arrest. It does so through the downregulation of the synthesis of cyclin D1, a protein known to be elevated in a variety of tumors. In addition, KU-55933 treatment during serum starvation triggers apoptosis in these cancer cells. Research results suggest that KU-55933 may be a novel chemotherapeutic agent targeting cancer resistant to traditional chemotherapy or immunotherapy due to aberrant activation of Akt. Furthermore, KU-55933 completely abrogates rapamycin-induced feedback activation of Akt. Combination of KU-55933 and rapamycin not only induces apoptosis, which is not seen in cancer cells treated only with rapamycin, but also shows better efficacy in inhibiting cancer cell proliferation than each drug alone. Synonyms: KU 55933; KU-55933; KU55933. CAS No. 587871-26-9. Molecular formula: C21H17NO3S2. Mole weight: 395.49. | |
KU59403 Quick inquiry Where to buy Suppliers range | KU59403 is a potent and selective ATM (Ataxia telangiectasia mutated) inhibitor with with potential anticancer activity. KU59403 was not cytotoxic to human cancer cell lines (SW620, LoVo, HCT116, and MDA-MB-231) per se but significantly increased the cytotoxicity of topoisomerase I and II poisons: camptothecin, etoposide, and doxorubicin. Chemo- and radiosensitization by ATM inhibition was not p53-dependent. Following administration to mice, KU59403 distributed to tissues and concentrations exceeding those required for in vitro activity were maintained for at least 4 hours in tumor xenografts. KU59403 significantly enhanced the antitumor activity of topoisomerase poisons in mice bearing human colon cancer xenografts (SW620 and HCT116) at doses that were nontoxic alone and well-tolerated in combination. Chemosensitization was both dose- and schedule-dependent. KU59403 represents a major advance in ATM inhibitor development, being the first compound to show good tissue distribution and significant chemosensitization in in vivo models of human cancer, without major toxicity. KU59403 provides the first proof-of-principle preclinical data to support the future clinical development of ATM inhibitors. Synonyms: KU59403; KU 59403; KU-59403. Grades: 98%. CAS No. 845932-30-1. Molecular formula: C29H32N4O4S2. Mole weight: 564.72. | |
KU-60019 Quick inquiry Where to buy Suppliers range | KU-60019 is a potent and selective ATM inhibitor. KU-60019 is 10-fold more effective than KU-55933 at blocking radiation-induced phosphorylation of key ATM targets in human glioma cells. As expected, KU-60019 is a highly effective radiosensitizer of human glioma cells. KU-60019 inhibits the DNA damage response, reduces AKT phosphorylation and prosurvival signaling, inhibits migration and invasion, and effectively radiosensitizes human glioma cells. Synonyms: KU60019; KU 60019; 2-((2R,6S)-2,6-dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide. Grades: 98%. CAS No. 925701-49-1. Molecular formula: C30H33N3O5S. Mole weight: 547.67. | |
Ku70 Quick inquiry Where to buy Suppliers range | KU70 is a cell-penetrating peptide used to block the activity of KU70 antibody. Synonyms: H-Val-Pro-Met-Leu-Lys-Pro-Met-Leu-Lys-Glu-OH; L-valyl-L-prolyl-L-methionyl-L-leucyl-L-lysyl-L-prolyl-L-methionyl-L-leucyl-L-lysyl-L-glutamic acid. Grades: >98%. Molecular formula: C54H96N12O13S2. Mole weight: 1185.55. | |
Ku70 Quick inquiry Where to buy Suppliers range | KU70 Peptide is a peptide corresponds to 15 amino acids of KU70 and is used for blocking the activity of KU70 antibody. Uses: Various Peptides. Product ID: GR2137. | |
KUANONIAMINE C Quick inquiry Where to buy Suppliers range | Kuanoniamine C, 133401-12-4, N-[2-(4-thia-6,9,19-triazapentacyclo[10.7.1.03,7.08,20.013,18]icosa-1,3(7),5,8,10,12(20),13,15,17-nonaen-2-yl)ethyl]propanamide, Dercitamide, NSC705533, CHEMBL463916, SCHEMBL17243840, NSC-705533, SMP2_000225, NCI60_037644, Propanamide,3,2-mn]thiazolo[4,5-b]acridin-9-yl)ethyl]-. | |
Kudzuvine root dry extract Quick inquiry Where to buy Suppliers range | Kudzuvine root dry extract. Uses: For analytical and research use. Group: European Pharmacopoeia (Ph. Eur.); Pharmacopoeial Standards. Catalog: APS009270. Format: Neat. Product Type: API. Shipping: Ice pack (-20°C). | |
Kukoamine a Quick inquiry Where to buy Suppliers range | Kukoamine a. Group: Heterocyclic Organic Compound. Alternative Names: kukoamine A; 1, 14-Bis (dihydrocaffeoyl)spermidine; N, N-[1, 4-Butanediylbis (imino-3, 1-propanediyl)]bis[3, 4-dihydroxybenzenepropanamide]; N, N-[Tetramethylenebis (iminotrimethylene)]bis[3- (3, 4-dihydroxyphenyl)propionamide]; N1, N12-Bis (dihydrocaffeoyl) spermine. CAS No. 75288-96-9. Molecular formula: C28H42N4O6. Mole weight: 0. Density: 1.213±0.06 g/cm3 (20 ºC 760 Torr). | |
Kukoamine A Quick inquiry Where to buy Suppliers range | Kukoamine A. Group: Biochemicals. Grades: Plant Grade. CAS No. 75288-96-9. Pack Sizes: 10mg. Molecular Formula: C28H42N4O6, Molecular Weight: 530.66. US Biological Life Sciences. | Worldwide |
Kukoamine B Quick inquiry Where to buy Suppliers range | Kukoamine B. Group: Biochemicals. Grades: Plant Grade. CAS No. 164991-67-7. Pack Sizes: 10mg. Molecular Formula: C28H42N4O6, Molecular Weight: 530.66. US Biological Life Sciences. | Worldwide |
Kukui Nut Oil Quick inquiry Where to buy Suppliers range | Kukui nut oil (or candlenut oil) is a unique specialty oil used widely in the personal care and soap industry. The oils has high levels of oleic (C18:1) and linoleic (C18:2) essential fatty acids which make the oil an effective emollient. Extraction method: Cold pressed, refined. SAP Value: 185-195. Uses: Skin care and hair products. Group: Emollients/Oils/Wax. CAS No. 8015-80-3. Product ID: ACM8015803-1. Appearance: Clear honey-colored liquid. | |
Kumbicin C Quick inquiry Where to buy Suppliers range | Kumbicin C is a bis-indolyl benzenoid fungal metabolite produced by A. kumbius FRR6049. Kumbicin C was found to inhibit the growth of mouse myeloma cells (IC50 = 0.74 μg/mL) and the Gram-positive bacterium Bacillus subtilis (MIC = 1.6 μg/mL). Synonyms: 5,8-di-1H-indol-3-yl-7-methoxy-2,2-dimethyl-2H-1-benzopyran-6-ol. Grades: ≥95%. CAS No. 1878151-58-6. Molecular formula: C28H24N2O3. Mole weight: 436.50. | |
Kumquat Base Quick inquiry Where to buy Suppliers range | Kumquat Base. CAS No. MIXTURE. VIGON Item # 504913. Categories: Speciality Ingrdients Suppliers, Fragrances, Perfumers. | America & Internationally |
Kunitz-type serine protease inhibitor 1 Quick inquiry Where to buy Suppliers range | Kunitz-type serine protease inhibitor 1. Uses: Antimicrobial Peptides. Product ID: AF739. | |
Kunitz-type serine protease inhibitor 1 Quick inquiry Where to buy Suppliers range | Kunitz-type serine protease inhibitor 1 is a Kunitz protease inhibitor isolated from Xanthosoma sagittifolium. It has activity against gram-negative bacteria. Synonyms: Pro-Val-Val-Asp-Thr-Thr-Gly-Asn-Asn-Pro-Leu-Gln-Gln-Gln-Glu-Glu-Tyr-Tyr-Val. Grades: 96.4%. Molecular formula: C96H144N24O35. Mole weight: 2194.34. | |
Kurarinone Quick inquiry Where to buy Suppliers range | Kurarinone. Group: Biochemicals. CAS No. 34981-26-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Kurarinone, 2'-O-methyl- Quick inquiry Where to buy Suppliers range | Kurarinone, 2'-O-methyl-. Group: Biochemicals. Grades: Plant Grade. CAS No. 270249-38-2. Pack Sizes: 5mg. Molecular Formula: C27H32O6, Molecular Weight: 452.55. US Biological Life Sciences. | Worldwide |
Kurasoin A Quick inquiry Where to buy Suppliers range | It is produced by the strain of Paecilomyces sp. FO-3184, Kurasoin A has the effect of inhibiting the protein fannicyl transferase. Synonyms: (+)-Kurasoin A; (S)-3-Hydroxy-4-(4-hydroxyphenyl)-1-phenyl-2-butanone. CAS No. 182232-62-8. Molecular formula: C16H16O3. Mole weight: 256.30. | |
Kurasoin B Quick inquiry Where to buy Suppliers range | It is produced by the strain of Paecilomyces sp. FO-3184, Kurasoin B has the effect of inhibiting the protein fannicyl transferase. Synonyms: (+)-Kurasoin B. Molecular formula: C18H17NO2. Mole weight: 279.33. | |
Kuromanin chloride Quick inquiry Where to buy Suppliers range | Kuromanin chloride. Group: Heterocyclic Organic Compound. Alternative Names: CHRYSANTHEMIN;CYANIDIN-3-O-GLUCOSIDE CHLORIDE;CYANIDIN-3-GLUCOSIDE;CYANIDIN-3-GLUCOSIDE CHLORIDE;KUROMANIN CHLORIDE;KUROMANINE CHLORIDE;ASTERIN;1-benzopyrylium,5,7-dihydroxy-2-(3,4-dihydroxyphenyl)-3-(beta-d-glucopyranosyl. CAS No. 7084-24-4. Molecular formula: C21H21ClO11. Mole weight: 484.84. | |
Kuromanin chloride Quick inquiry Where to buy Suppliers range | Kuromanin chloride is a natural compound found in Amelanchier spicata, Acer paxii. It is a scavenger of peroxynitrite and that exert a protective effect against endothelial dysfunction and vascular failure induced by peroxynitrite. Uses: Antioxidative. Synonyms: Kuromanine; Chrysontemin; Cyanidin-3-glucoside chloride. Grades: >98%. CAS No. 7084-24-4. Molecular formula: C21H21O11 Cl. Mole weight: 484.85. | |
Kushenol A Quick inquiry Where to buy Suppliers range | Kushenol A. Group: Biochemicals. Grades: Plant Grade. CAS No. 99217-63-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Kushenol F (Sophoraflavanone G) Quick inquiry Where to buy Suppliers range | Kushenol F (Sophoraflavanone G). Group: Biochemicals. Alternative Names: 2?,4?,5,7-Tetrahydroxy-6-lavandulylflavanone; Norkurarinone;34981-24-3. Grades: Plant Grade. CAS No. 97938-30-2. Pack Sizes: 10mg. Molecular Formula: C25H28O6, Molecular Weight: 424.485999999999. US Biological Life Sciences. | Worldwide |
Kushenol I Quick inquiry Where to buy Suppliers range | Kushenol I. Group: Biochemicals. Grades: Plant Grade. CAS No. 99119-69-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Kushenol I Quick inquiry Where to buy Suppliers range | Kushenol I is a compound of the flavonoid class found in the Sophora flavescens Ait. Kushenol I is a GABAA receptor modulator and a Sodium-dependent glucose cotransporter 2(SGLT2) inhibitor. Synonyms: NSC 668937. Grades: >98%. CAS No. 99119-69-4. Molecular formula: C26H30O7. Mole weight: 454.5. |