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| Product | Description | |
|---|---|---|
| KKL-35 | KKL-35 is a trans-translation tagging reaction inhibitor (IC50= 0.9 μM), thereby inhibiting bacterial growth by blocking ribosome rescue. Synonyms: KKL-35; KKL 35; KKL35; 4-chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]benzamide; F1374-0110; 4-chloro-N-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)benzamide. CAS No. 865285-29-6. Molecular formula: C15H9ClFN3O2. Mole weight: 317.7. |  |
| KKL-40 | KKL-40 is a small molecule inhibitor that targets the trans-transcription process and is effective against methicillin-sensitive and -resistant Staphylococcus aureus (S. aureus) as well as other Gram-positive pathogens including vancomycin-resistant Enterococcus faecium, Bacillus subtilis, and Streptococcus pyogenes. KKL-40 synergizes with the human antimicrobial peptide LL-37 to inhibit S. aureus, but does not synergize with other antibiotics such as daptomycin, kanamycin, or erythromycin. Trans-transcription is an extreme form of recoding, and KKL-40 inhibits trans-transcription but is nontoxic to HeLa cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 865285-47-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-116863. |  |
| KL001 | KL001 is a small molecule that specifically interacts with cryptochrome (CRY), blocks proteasome-mediated degradation of CRY1 and CRY2. Lengthens circadian period in mouse NIH-3T3 fibroblasts without altering casein kinase activity. Uses: Cryptochrome protein (cry) stabilizer. Synonyms: KL 001; KL-001; N-(3-(9H-carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide. Grades: ≥98%. CAS No. 309928-48-1. Molecular formula: C21H22N2O4S. Mole weight: 398.48. | |
| KL001 | KL001 is a Cryptochrome protein (CRY) stabilizer. KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. In combination with mathematical modeling, our studies using KL001 revealed that CRY1 and CRY2 share a similar functional role in the period regulation. Furthermore, KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes. KL001 thus provides a tool to study the regulation of CRY-dependent physiology and aid development of clock-based therapeutics of diabetes. Uses: Designed for use in research and industrial production. Additional or Alternative Names: KL001; KL-001; KL 001. Product Category: Others. Appearance: Solid powder. CAS No. 309928-48-1. Molecular formula: C21H22N2O4S. Mole weight: 398.48. Purity: >98%. IUPACName: N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)methanesulfonamide. Canonical SMILES: CS(=O)(N(CC(O)CN1C2=C(C3=C1C=CC=C3)C=CC=C2)CC4=CC=CO4)=O. Product ID: ACM309928481. Alfa Chemistry ISO 9001:2015 Certified. Categories: Kl2017. |  |
| KL001 | KL001. Group: Biochemicals. Alternative Names: N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-methanesulfonamide. Grades: Highly Purified. CAS No. 309928-48-1. Pack Sizes: 5mg, 10mg, 50mg. Molecular Formula: C21H22N2O4S, Molecular Weight: 398.48. US Biological Life Sciences. |  Worldwide |
| KL 001 | KL 001. Group: Biochemicals. Grades: Purified. CAS No. 309928-48-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| KL002 | KL002. Group: Biochemicals. Alternative Names: N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-iodophenyl)-methanesulfonamide. Grades: Highly Purified. CAS No. 439141-72-7. Pack Sizes: 5mg, 10mg, 50mg. Molecular Formula: C22H21IN2O3S, Molecular Weight: 520.38. US Biological Life Sciences. | Worldwide |
| KL-11743 | KL-11743 is a potent, orally active and glucose-competitive inhibitor of the class I glucose transporters, with IC50s of 115, 137, 90 and 68 nM for GLUT1, GLUT2, GLUT3 and GLUT4, respectively. It specifically blocks glucose metabolism and induces cell death in concert with electron transport inhibitors. Synonyms: NSC783733; Acetamide, 2-[3-[6-ethoxy-4-[[4-(1H-pyrazol-4-yl)phenyl]amino]-2-quinazolinyl]phenoxy]-N-(1-methylethyl)-. Grades: ≥98%. CAS No. 1369452-53-8. Molecular formula: C30H30N6O3. Mole weight: 522.60. | |
| KL1333 | KL1333, a derivative of β-lapachone, is an orally available NAD+ modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1800405-30-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-128895. | |
| KL-50 | KL-50 is a selective toxin toward tumors that lack the DNA repair protein O 6 -methylguanine-DNA-methyltransferase (MGMT), which reverses the formation of O 6 -alkylguanine lesions. KL-50 activates DNA damage response pathways and cycle arrest in MGMT-cells, independent of mismatch repair (MMR). KL-50 is promising for research of brain tumors that lack the DNA repair protein MGMT [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1161826-19-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164496. | |
| KLD12 | KLD12, a hydrogel obtained from the self-assembled peptide, regulates in vitro chondrogenesis of bovine bone marrow stromal cells. Synonyms: Ac-Lys-Leu-Asp-Leu-Lys-Leu-Asp-Leu-Lys-Leu-Asp-Leu-NH2; N-acetyl-L-lysyl-L-leucyl-L-alpha-aspartyl-L-leucyl-L-lysyl-L-leucyl-L-alpha-aspartyl-L-leucyl-L-lysyl-L-leucyl-L-alpha-aspartyl-L-leucinamide; L-Leucinamide, N2-acetyl-L-lysyl-L-leucyl-L-α-aspartyl-L-leucyl-L-lysyl-L-leucyl-L-α-aspartyl-L-leucyl-L-lysyl-L-leucyl-L-α-aspartyl-. Grades: ≥95% by HPLC. CAS No. 800379-47-9. Molecular formula: C68H122N16O19. Mole weight: 1467.79. | |
| Kleermount, in Xylene, Laboratory Grade, 100 mL | Kleermount®, in Xylene, Laboratory Grade, 100 mL - A permanent neutral mounting medium that will not turn acid or darken with age. Storage Code: Red; flammable. DOT Class: Flammable. Grades: chem-grade laboratory. Product ID: 871343. -- SOLD FOR EDUCATIONAL USE ONLY -- |  |
| Klemm's No.2 Reagent | Stain or tint etch for etching cast iron, copper and tin. Group: Etchants. |  |
| Klemm's Reagent | For etching alpha-beta brass, bonze, tin, cast iron phosphides, ferrite, martensite, retained austenite, zinc and steel temper embrittlement. Group: Etchants. | |
| KLF5 Inhibitor, CID 5951923 (2- ( (1, 1-Dioxidotetra hydrothiophen-3-yl, methyl)amino)-2-oxoethyl-(2E)-3-(3-nitrophenyl)prop-2-enoate) | A cell-permeable phenylpropenoate compound that inhibits the proliferation of colon cancer cell lines exhibiting high levels of KLF5 (IC50=1.6uM in DLD-1 cells). Downregulates the expression of early growth response protein 1 (EGR1), which modulates KLF5 expression at transcription level. Shown to activate the EGFR/ERK pathway by stimulating phosphorylation of EGFR-Tyr1068 and ERK1/2-Thr202/Tyr204. Also, up-regulates the phosphorylation of p38 MAPK-Thr180/Tyr182. Group: Biochemicals. Grades: Highly Purified. CAS No. 749872-43-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| KLH 45 | KLH 45 is a selective, potent and irreversible inhibitor of DDHD domain containing 2 (DDHD2) with IC50 value of 1.3 nM. It is selective for DDHD2 over 40 other serine hydrolases. It shows cross-reactivity with ABHD6. It is active in vivo and increases brain triacylglycerol levels in mouse brain. Synonyms: KLH45; KLH-45; KLH 45; N-Cyclohexyl-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]-2H-1,2,3-triazole-2-carboxamide. Grades: ≥98% by HPLC. CAS No. 1632236-44-2. Molecular formula: C24H25F3N4O2. Mole weight: 458.48. | |
| KLS-13019 | KLS-13019, an azetidine derivative, could be a neuroprotective agent and has been found to exbihit much more effective than cannabidiol. Synonyms: KLS-13019; KLS 13019; KLS13019; 1-(3-(((1'R,2'R)-2,6-dihydroxy-5'-methyl-2'-(prop-1-en-2-yl)-1',2',3',4'-tetrahydro-[1,1'-biphenyl]-4-yl)methyl)azetidin-1-yl)ethan-1-one. Grades: 98%. CAS No. 1801243-39-9. Molecular formula: C22H29NO3. Mole weight: 355.48. | |
| KM11060 | KM11060 is a mutated F508del cystic fibrosis transmembrane conductance regulator (CFTR) corrector. KM11060 is an analog of sildenafil, which restores a function of the F508del mutated CFTR chloride channel. KM11060 appears to be more potent than sildenafil, forskolin, and genistein. Synonyms: KM11060; KM-11060; KM 11060. Grades: 98%. CAS No. 774549-97-2. Molecular formula: C19H17Cl2N3O2S. Mole weight: 422.324. | |
| KM 11060 | KM 11060. Group: Biochemicals. Grades: Purified. CAS No. 774549-97-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| KM 91104 | KM 91104. Group: Biochemicals. Alternative Names: 3,4-Dihydroxybenzoic Acid 2-[ (2-Hydroxyphenyl) methylene]hydrazide; 3, 4-Dihydroxy-N- (2-hydroxybenzylidene) benzohydrazide. Grades: Highly Purified. CAS No. 304481-60-5. Pack Sizes: 25mg. Molecular Formula: C14H12N2O4 , Molecular Weight: 272.26. US Biological Life Sciences. | Worldwide |
| KML-29 | KML-29 is an extremely specific monoacylglycerol lipase (MAGL) inhibitor. KML-2 should be useful to distinguish between actions of 2-arachidonoyl glycerol (an endogenous ligand of cannabinoid receptors that is deactivated by MAGL) and anandamide, another endocannabinoid. Group: Biochemicals. Alternative Names: 4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic Acid 2,2,2-Trifluoro-1-(trifluoromethyl)ethyl Ester; 1,1,1,3,3,3-Hexafluoropropan-2-yl 4- (Bis (benzo[d][1, 3]dioxol-5-yl) (hydroxy) methyl) piperidine-1-carboxylate; KML29. Grades: Highly Purified. CAS No. 1380424-42-9. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| KML-29 | KML-29, a effective MAGL inhibitor, has been found to have probable effect against neuropathic pain. IC50: 15, 43, and 5.9 nM (mouse, rat, and human brain proteomes). Uses: Kml-29 is a effective magl inhibitor that has been found to have probable effect against neuropathic pain. Synonyms: KML-29; KML29; KML 29; SCHEMBL15100615; SXHQLPHDBLTFPM-UHFFFAOYSA-N; BDBM179929; IN2183; ZINC97949367. Grades: 98%. CAS No. 1380424-42-9. Molecular formula: C24H21F6NO7. Mole weight: 549.42. | |
| KMO Inhibitor I, Ro 61-8048 (Kynurenine-3-Monooxygenase Inhibitor I, Ro 61-8048 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide Dimethoxy-nitrophenyl-thiazolyl-benzenesulfonamide, Kynurenine-3-Hydroxylase Inhibitor I, Ro 61-8048) | A cell-permeable thiazolyl Benzene sulfonamide compound that acts as a potent, competitive and reversible inhibitor of kynurenine-3-monooxygenase activity (Ki=4.8nM; IC50=37nM). Reported to increase the circulating levels of kynurenic acid (KYNA), an excitatory amino acid receptors antagonist, lower reactive oxygen species [ROS], reduce neuronal loss and enhance the survival rate in several neuronal disease models. An orally bioavilable KMO Inhibitor II, JM6, a prodrug of Ro 61-8048 is also available. Group: Biochemicals. Grades: Highly Purified. CAS No. 199666-03-0. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S?, Molecular Weight: 421.5. US Biological Life Sciences. | Worldwide |
| KN62 | KN62 is a P2X7R antagonist (hP2X7 IC50=51 nM) and Ca2+/calmodulin-dependent protein kinase II inhibitor. KN62 inhibits the invasiveness of cancer cells in vitro and in vivo KN62 causes retrograde amnesia in the rat. KN62 attenuates glutamate release by inhibiting voltage-dependent Ca(2+)-channels. The effect of KN62 on Ca(2+)-influx appears to be specific to slowly-or non-inactivating conductances, and therefore presents KN62 as a potentially useful tool. Uses: Designed for use in research and industrial production. Additional or Alternative Names: KN62; KN-62; KN 62. Product Category: Antagonists. Appearance: Solid powder. CAS No. 127191-97-3. Molecular formula: C38H35N5O6S2. Mole weight: 721.85. Purity: >98%. IUPACName: (S)-4-(2-(N-methylisoquinoline-5-sulfonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl isoquinoline-5-sulfonate. Canonical SMILES: CN([C@@H](CC1=CC=C(OS(=O)(C2=C3C(C=NC=C3)=CC=C2)=O)C=C1)C(N4CCN(C5=CC=CC=C5)CC4)=O)S(C6=CC=CC7=C6C=CN=C7)(=O)=O. Product ID: ACM127191973. Alfa Chemistry ISO 9001:2015 Certified. | |
| KN 62 | 1-[N,O-bis(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, (S)-5-Isoquinolinesulfonic acid 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester C38H35N5O6S2Fw 721.88 98% white solid, selectively inhibits rat brain, Ca2+/cadmodulin-dependent protein kinase II, soluble in DMSO, MeOH. selectively inhibits rat brain Ca2+/cadmodulin-dependent protein kinase II. CAS No. 127191-97-3. Product ID: 1-01108. Molecular formula: C38H35N5O6S2. Mole weight: 721.88. Purity: 0.98. Properties: white solid, soluble in DMSO, MeOH, 4°C. Reference: J. Biol. Chem., 267, 12511, 1992; J. Biol. Chem., 265, 4315, 1990. Categories: KN-62. |  |
| KN-62 | KN-62. Group: Biochemicals. Grades: Purified. CAS No. 127191-97-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| KN-62 | KN-62 suppresses the A23187-induced autophosphorylation of Ca2+/CaM kinase in PC12 D cells. Uses: Enzyme inhibitors. Synonyms: KN-62; KN 62; KN62. Grades: >98%. CAS No. 127191-97-3. Molecular formula: C38H35N5O6S2. Mole weight: 721.84. | |
| KN-62 (1-(N,O-Bis-[5-isoquinolinesulfonyl]-N-methyl-L-tyrosyl)-4-phenylpiperazine, (S)-5-Isoquinolinesulfonic Acid 4- (2-[ (5-Isoquinolinylsulfonyl) methylamino]- 3-oxo-3-[4-phenyl-1-piperazinyl]propyl) phenyl Ester,) | A specific inhibitor of Ca2+/Calmodulin-dependent protein kinase II. Group: Biochemicals. Alternative Names: 1-(N,O-Bis-[5-isoquinolinesulfonyl]-N-methyl-L-tyrosyl)-4-phenylpiperazine, (S)-5-Isoquinolinesulfonic Acid 4- (2-[ (5-Isoquinolinylsulfonyl) methylamino]- 3-oxo-3-[4-phenyl-1-piperazinyl]propyl) phenyl Ester. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| KN 92 | KN 92. Group: Biochemicals. Grades: Purified. CAS No. 1135280-28-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| KN-92 | KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cell. Synonyms: KN 92; KN92. Grades: >98%. CAS No. 176708-42-2. Molecular formula: C24H25ClN2O3S. Mole weight: 456.98. | |
| KN-92 hydrochloride | KN-92 is an inactive derivative of KN-93, the selective inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMKII). At concentrations up to 25 μM, KN-92 is ineffective at inhibiting CaMKII or arresting cell growth of NIH 3T3 fibroblasts. It is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. Synonyms: KN 92 hydrochloride; KN92 hydrochloride. Grades: >98%. CAS No. 1431698-47-3. Molecular formula: C24H26Cl2N2O3S. Mole weight: 493.45. | |
| KN-92 phosphate | KN-92 is an inactive analog of the CaM kinase II inhibitor KN 93. Synonyms: KN-92 phosphate; KN 92 phosphate; KN92 phosphate. Grades: >98%. CAS No. 1135280-28-2. Molecular formula: C24H28ClN2O7PS. Mole weight: 554.98. | |
| KN 93 | KN 93. Group: Biochemicals. Grades: Purified. CAS No. 139298-40-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| KN-93 | KN-93 is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II ( CaMKII ) with a K i of 370 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 139298-40-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15465. | |
| KN-93 | KN-93 is a selective Ca2+/calmodulin-dependent protein kinase II inhibitor, which has been implicated in the regulation of smooth muscle contractility. CaM kinase II activation was inhibited by KN-93 pretreatment (IC50 ~1 μM). KN-93 inhibited histamine-induced tonic force maintenance, whereas early force development and MLC20 phosphorylation responses during the entire time course were unaffected. Both force development and maintenance in response to KCl were inhibited by KN-93. Rapid increases in KCl-induced MLC20 phosphorylation were also inhibited by KN-93, whereas steady-state MLC20 phosphorylation responses were unaffected. In contrast, phorbol 12,13-dibutyrate (PDBu) did not activate CaM kinase II and PDBu-stimulated force development was unaffected by KN-93. Thus KN-93 appears to target a step(s) essential for force maintenance in response to physiological stimuli, suggesting a role for CaM kinase II in regulating tonic contractile responses in arterial smooth muscle. Pharmacological activation of protein kinase C bypasses the KN-93 sensitive step. Uses: Protein kinase inhibitors. Synonyms: KN 93; KN93. Grades: >98%. CAS No. 139298-40-1. Molecular formula: C26H29ClN2O4S. Mole weight: 501.04. | |
| KN-93 | KN-93. Group: Biochemicals. Alternative Names: N- [2- [ [ [3- (4-Chlorophenyl) -2-propen-1-yl] methylamino] methyl] phenyl] -N- (2-hydroxyethyl) -4-methoxy Benzene sulfonamide. Grades: Highly Purified. CAS No. 139298-40-1. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C26H29ClN2O4S. US Biological Life Sciences. | Worldwide |
| KN-93 hydrochloride | KN-93 hydrochloride is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II ( CaMKII ) with a K i of 370 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1956426-56-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15465A. | |
| KN-93 hydrochloride | KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMKII), a multifunctional serine/threonine protein kinase that transmits calcium signals in various cellular processes. KN-93 is commonly used for determining cellular functions. Synonyms: KN-93 HCl; N-[2-[[[(E)-3-(4-chlorophenyl)prop-2-enyl]-methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide hydrochloride. Grades: ≥98%. CAS No. 1956426-56-4. Molecular formula: C26H29ClN2O4S·HCl. Mole weight: 537.5. | |
| KN 93 phosphate | KN 93 phosphate. Group: Biochemicals. Grades: Purified. CAS No. 1188890-41-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| KN-93 phosphate | KN-93 phosphate is a novel membrane-permeant synthetic inhibitor of purified neuronal CaMK-II , with K i of 370 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1913269-12-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-15465B. | |
| KN-93 Phosphate | KN-93 Phosphate is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.37 μM, no remarkable inhibitory effects on APK, PKC, MLCK or Ca2+-PDE activities. Synonyms: (E)-N- (2- ( ( (3- (4-chlorophenyl)allyl) (methyl)amino)methyl)phenyl)-N- (2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate; KN93; KN 93; KN-93; KN-93 phosphate. Grades: >98%. CAS No. 1188890-41-6. Molecular formula: C26H32ClN2O8PS. Mole weight: 599.03. | |
| KN-93 (Water Soluble) | Selective Ca2+/calmodulin-dependent protein kinase II inhibitor. Insulin release inhibitor. Acid secretion inhibitor. G1 cell cycle arrest inducer. Apoptosis inducer. Ion channel inhibitor. ROS inducer. Androgen receptor inhibitor. Group: Biochemicals. Alternative Names: 2-amino-N-(4-chlorocinnamyl)-N-methylbenzylamine. Grades: Highly Purified. CAS No. 139298-40-1. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C26H29ClN2O4S H3PO4. US Biological Life Sciences. | Worldwide |
| KNK437 | KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40. Synonyms: KNK437; KNK-437; KNK 437. Grades: 98%. CAS No. 218924-25-5. Molecular formula: C13H11NO4. Mole weight: 245.23. | |
| Knorr-2-Chlorotrityl Resin | Knorr-2-Chlorotrityl Resin. Group: Unsubstituted resins. Alternative Names: Knorr-2-Chlorotrityl Resin. Pack Sizes: 5g, 25g. | |
| KNT-127 | KNT-127 is a potent δ-opioid receptor agonist that crosses the blood-brain barrier (BBB). KNT-127 is highly selective to the δ receptor, with K i values of 0.16, 21.3 and 153 nM for δ, μ and κ receptors, respectively. KNT-127 increases the release of dopamine and L-glutamate in the striatum, nucleus accumbens, and prefrontal cortex. KNT-127 has analgesic, antidepressant and antianxiety activities [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1256921-89-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-120511. | |
| Ko 143 | Ko 143 is a potent and selective inhibitor of BCRP, preventing the export of mitoxantrone and topotecan in breast cancer cell lines. It is much less effective at the transporters P-glycoprotein and multidrug resistance-associated protein 1, MRP1. Ko 143 is effective in vivo in mice. Synonyms: Ko-143; Ko-143; Ko-143. Grades: >98%. CAS No. 461054-93-3. Molecular formula: C26H35N3O5. Mole weight: 469.57. | |
| Ko 143 | Ko 143. Group: Biochemicals. Grades: Purified. CAS No. 461054-93-3. Pack Sizes: 1mg, 10mg. US Biological Life Sciences. | Worldwide |
| Koaburaside | Koaburaside is a cytoprotective and anti-inflammatory natural compound. Koaburaside shows antioxidant activity with an IC50 of 9.0 μM for DPPH-free radical scavenging assay. Koaburaside inhibits histamine release and expressions of IL-6 and TNF-α in human mast cells. Koaburaside also effectively inhibits influenza A neuraminidase. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Powder. CAS No. 41653-73-0. Molecular formula: C14H20O9. Mole weight: 332.3. Purity: 0.98. IUPACName: (2S,3R,4S,5S,6R)-2-(4-hydroxy-3,5-dimethoxyphenoxy)-6-(hydroxymethyl)oxane-3,4,5-triol. Canonical SMILES: COC1=CC(=CC(=C1O)OC)OC2C(C(C(C(O2)CO)O)O)O. Product ID: ACM41653730. Alfa Chemistry ISO 9001:2015 Certified. | |
| Kobe0065 | Kobe0065 is a small-molecule Ras inhibitor that displays antitumor activity by blocking the Ras-effector interaction. Kobe0065 binds to Ras-GTP, blocking interactions with Raf kinase. Synonyms: Kobe0065; Kobe 0065; Kobe0065. CAS No. 436133-68-5. Molecular formula: C15H11ClF3N5O4S. Mole weight: 449.79. | |
| kobe2602 | Kobe2602, an analog of Kobe0065 , is a potent and selective RAS inhibitor, which exhibits inhibitory activity toward H-Ras GTP-c-Raf-1 binding both in vivo and in vitro. Synonyms: Kobe2602; Kobe 2602; Kobe-2602. CAS No. 454453-49-7. Molecular formula: C14H9F4N5O4S. Mole weight: 419.31. | |
| Kobophenol A | Kobophenol A, an oligomeric stilbene, blocks the interaction between the ACE2 receptor and S1-RBD with an IC50 of 1.81 μM and inhibits SARS-CoV-2 viral infection in cells with an EC50 of 71.6 μM. Kobophenol A inhibits the activity of partially purified rat brain protein kinase C (PKC) with an IC50 of 52 μM. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Powder. CAS No. 124027-58-3. Molecular formula: C56H44O13. Mole weight: 925. Purity: 0.98. IUPACName: 5-[(2S,3R,4S,5S)-4-[(2S,3S)-3-[(2R,3R)-3-(3,5-dihydroxyphenyl)-6-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-1-benzofuran-4-yl]-6-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-1-benzofuran-4-yl]-2,5-bis(4-hydroxyphenyl)oxolan-3-yl]benzene-1,3-diol. Canonical SMILES: C1=CC(=CC=C1C2C(C(C(O2)C3=CC=C(C=C3)O)C4=CC(=CC5=C4C(C(O5)C6=CC=C(C=C6)O)C7=CC(=CC8=C7C(C(O8)C9=CC=C(C=C9)O)C1=CC(=CC(=C1)O)O)O)O)C1=CC(=CC(=C1)O)O)O. Product ID: ACM124027583. Alfa Chemistry ISO 9001:2015 Certified. | |
| Kodaistatin A | Kodaistatin A is originally isolated from Asperrgilus terreus Thom DSM 11237. It inhibits the glucose-6-phosphotransferase T1 (G-6-P-T1) with the IC50 of 80 nmol/L. Molecular formula: C35H34O11. Mole weight: 630.64. | |
| Kodaistatin C | Kodaistatin B is originally isolated from Asperrgilus terreus Thom DSM 11237. It inhibits the glucose-6-phosphotransferase T1 (G-6-P-T1) with the IC50 of 130 nmol/L. Synonyms: Kodaistatin B. Molecular formula: C35H34O12. Mole weight: 646.64. | |
| KOD DNA Polymerase from Thermococcus kodakaraensis, Recombinant | KOD is a high fidelity thermostable DNA polymerase that amplifies target DNA up to 6 kbp with superior accuracy and yield for PCR applications. The enzyme's 3'?5' exonuclease-dependent proofreading activity results in a lower PCR mutation frequency than any other commercially available DNA polymerase. The elongation rate and processivity are 5 times and 10 to 15 times higher, respectively, than for Pfu DNA polymerase, resulting in highly accurate and robust yield, in a short reaction time. Higher fidelity than pfu dna polymerase--excellent for cloninggreater yield--extension speed is 2x faster than taq dna polymerase and 5x faster than pfu dna polymerasehigher processivity--sequential nucleotide polymerization is 10- to 15-fold greater than pfu and tli dna polymerasesamplifies plasmid and lambda dna templates up to 6 kbpamplifies genomic dna templates up to 2 kbpno truncated amplification products. Group: Enzymes. Purity: > 90% homogeneous by SDS-PAGE. DNA Polymerase. Storage: at -20°C. Source: E. coli. Species: Thermococcus kodakaraensis. KOD DNA polymease; DNA polymease; KOD. Cat No: NATE-1632. |  |
| Kojibiose | Kojibiose, a remarkable biomedicine, stands as a powerful solution for an array of dermatological afflictions. Renowned for its profound capacity to impede tyrosinase activity, this therapeutic wonder effectively combats skin pigmentation maladies like melasma and hyperpigmentation. Synonyms: 2-O-(a-D-Glucopyranosyl)-a-D-glucopyranose; Glc-a-1,2-Glc; D-Glucose, 2-O-α-D-glucopyranosyl-; 2-O-α-D-Glucopyranosyl-D-glucose. Grades: ≥95%. CAS No. 2140-29-6. Molecular formula: C12H22O11. Mole weight: 342.30. | |
| Kojibiose | Kojibiose, an orally active prebiotic disaccharide, can specifically inhibit the activity of α-glucosidase I. kojibiose is a proliferation factor for Bifidobacterium , lactic acid bacteria, and eubacteria. kojibiose is a low-calorie sweetener capable of increasing the absorption of iron. Kojibiose exhibits antitoxic activity. Kojibiose reduces hepatic expression of inflammatory markers in vivo [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2140-29-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113133. | |
| kojibiose phosphorylase | The enzyme from Thermoanaerobacter brockii can act with α-1,2-oligoglucans, such as selaginose, as substrate, but more slowly. The enzyme is inactive when dissaccharides with linkages other than α-1,2 linkages, such as sophorose, trehalose, neotrehalose, nigerose, laminaribiose, maltose, cellobiose, isomaltose, gentiobiose, sucrose and lactose, are used as substrates. Group: Enzymes. Enzyme Commission Number: EC 2.4.1.230. CAS No. 206566-36-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2460; kojibiose phosphorylase; EC 2.4.1.230; 206566-36-1. Cat No: EXWM-2460. | |
| Kojic acid | 100g Pack Size. Group: Aroma Chemicals, Biochemicals, Flavours and Fragrance Materials, Ligands. Formula: C6H6O4. CAS No. 501-30-4. Prepack ID 31686564-100g. Molecular Weight 142.11. See USA prepack pricing. |  |
| Kojic acid | 25g Pack Size. Group: Aroma Chemicals, Biochemicals, Flavours and Fragrance Materials, Ligands. Formula: C6H6O4. CAS No. 501-30-4. Prepack ID 31686564-25g. Molecular Weight 142.11. See USA prepack pricing. | |
| Kojic acid | Kojic acid. CAS No. 501-30-4. Product ID: 8-01277. Molecular formula: C6H6O4. Mole weight: 142.1. Purity: 0.99. Properties: | |
| Kojic acid | Kojic acid is a substance produced by Aspergillus oryzae that is orally effective and can also be absorbed transdermally. Kojic acid exhibits various biological activities, including anti-aging, anti-nematode, antimicrobial, antioxidant, and anti-inflammatory effects. Kojic acid is a Tyrosinase inhibitor with an Mushroom Tyrosinase IC 50 of 182.7 μM. Kojic acid prevents melanin production by capturing copper ions that bind to the tyrosinase active site, thus inhibiting its activation. Kojic acid also suppresses the NF-κB and p21 signaling pathways in human keratinocytes. Kojic acid derivatives have anticancer activity [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Natural products. CAS No. 501-30-4. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-W050154. | |
| Kojic Acid | Kojic Acid. Synonyms: Pyran-4-one, 5-hydroxy-2-(hydroxymethyl). CAS No. 501-30-4. Pack Sizes: 5, 10, 25 g in poly bottle. Product ID: CDC10-0055. Molecular formula: C6H6O4. Category: Antioxidant Cosmetic Chemicals. Product Keywords: Cosmetic Ingredients; Antioxidant Cosmetic Chemicals; Kojic Acid; CDC10-0055; 501-30-4; C6H6O4; Pyran-4-one, 5-hydroxy-2-(hydroxymethyl); 207-922-4; MFCD00006580; 501-30-4. Purity: ≥98.5% (HPLC). Color: White to beige-brown. EC Number: 207-922-4. Physical State: Crystalline Powder. Solubility: DMSO (Slightly), Methanol (Slightly, Sonicated). Quality Level: 200. Application: kojic acid is a skin-lightening agent that acts through anti-oxidant activity. Kojic acid is a tyrosinase inhibitor, although it is not as effective as licorice extract. When combined with allantoin and other proper ingredients in sunscreen preparations, the mixture can inhibit uV-caused erythema and accelerate wound healing. It is also found to be skin sensitizing and can be irritating. Boiling Point: 179.65°C (rough estimate). Melting Point: 152-155 °C (lit.). Density: 1.1712 g/mL(rough estimate). |  |
| Kojic Acid | It is produced from the Aspergillus parasiticus. Kojic Acid has anti-leptospira effect with MIC of 1-10 μg/mL. It is also a tyrosinase inhibitor, which acts as a chelating agent that inhibits the production of melanin and should help chloasma in vitro. Synonyms: 5-Hydroxy-2-(hydroxymethyl)-4-pyrone; 4H-PYRAN-4-ONE, 5-HYDROXY-2-(HYDROXYMETHYL)-; 2-Hydroxymethyl-5-hydroxy-gamma-pyrone; NSC 1942. Grades: ≥99%. CAS No. 501-30-4. Molecular formula: C6H6O4. Mole weight: 142.11. | |
| Kojic Acid | Kojic acid (5-hydroxy-2-hydroxymethyl-4-pyrone) is a by-product in the fermentation process of malting rice. Mild inhibitor of the formation of pigment in plant and animal tissues. Uses: All kinds of skin-lightening products including lotions, creams, fluids, makeup products. Additional or Alternative Names: Pyran-4-one, 5-hydroxy-2-(hydroxymethyl). Product Category: Inhibitors. Appearance: Solid. CAS No. 501-30-4. Molecular formula: C6H6O4. Mole weight: 142.11. Purity: 0.98. IUPACName: 5-Hydroxy-2-(hydroxymethyl)pyran-4-one. Canonical SMILES: C1=C(OC=C(C1=O)O)CO. Density: 1.1712 g/cm³. Product ID: ACM501304. Alfa Chemistry ISO 9001:2015 Certified. | |
| Kojic acid 99+% | A naturally occurring chelation agent. Kojic acid may be used on cut fruits to prevent oxidative browning, in seafood to preserve pink and red colors, and in cosmetics to lighten skin. As an example of the latter, it is used to treat skin diseases like melasm. Group: Biochemicals. Alternative Names: 5-Hydroxy-2-hydroxymethyl-4H-pyran-4-one; 5-Hydroxy-2-hydroxymethyl-4-pyrone; 5-Hydroxy-2-(hydroxymethyl)-4H-pyranone; 2-(Hydroxymethyl)-5-hydroxy-4H-pyran-4-one; NSC 1942. Grades: Reagent Grade. CAS No. 501-30-4. Pack Sizes: 1Kg, 5Kg, 10Kg. US Biological Life Sciences. | Worldwide |
| Kojic acid dipalmitate | Kojic Acid Dipalmitate is a fat-soluble derivative of kojic acid. Due to the special function of the hydroxyl group in its molecular structure, it will not affect the performance of other cosmetic additives and can be well compounded with other cosmetic raw materials. Synonyms: KAD. Grades: 98%. CAS No. 79725-98-7. Molecular formula: C37H64O6. Mole weight: 604.9. | |
| Kojic acid dipalmitate | Kojic acid dipalmitate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (4-Oxo-5-(palmitoyloxy)-4H-pyran-2-yl)methyl palmitate. Product Category: Material of cosmetics. Appearance: White to off white crystalline powder. CAS No. 79725-98-7. Molecular formula: C38H66O6. Mole weight: 618.93. Density: 0.99 g/cm³. Product ID: ACM79725987. Alfa Chemistry ISO 9001:2015 Certified. | |
| Kojic acid dipalmitate | Kojic acid dipalmitate (Kojic dipalmitate) is a derivative of Kojic acid (HY-W050154), a fungal metabolite that can be produced by species of Aspergillus , Acetobacter and Penicillium. Kojic acid dipalmitate is a slow and reversible competitive inhibitor of tyrosinase. Kojic acid dipalmitate can be used for skin?lightening agent research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Kojic dipalmitate. CAS No. 79725-98-7. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-W099579. | |
| Kojic acid dipalmitate | Kojic acid dipalmitate. Group: Biochemicals. Alternative Names: (4-Oxo-5-(palmitoyloxy)-4H-pyran-2-yl)methyl palmitate. Grades: Highly Purified. CAS No. 79725-98-7. Pack Sizes: 250g, 500g, 1kg, 2kg, 5kg. Molecular Formula: C38H66O6. US Biological Life Sciences. | Worldwide |
| Kojic acid dipalmitate | 2-Palmitoyloxymethyl-5-palmitoyloxy-pyrone. CAS No. 79725-98-7. Product ID: 8-04334. Molecular formula: C38H66O6. Mole weight: 618.94. | |
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