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| Product | Description | |
|---|---|---|
| ML-7 | ML-7 is a potent and selective inhibitor of myosin light chain(MLC) kinase with Ki value of 0.3 μM. It has been shown to protect cardiac function from ischemia/reperfusion (I/R) injury. It inhibts smooth-muscle myosin light chain kinase, protein kinase C (PKC) and cAMP-dependent protein kinase (PKA). Uses: Ml-7 hydrochloride has been shown to protect cardiac function from ischemia/reperfusion (i/r) injury. Synonyms: ML7; ML 7; 1-[(5-iodo-1-naphthyl)sulfonyl]-1,4-diazepane. Grades: >98%. CAS No. 109376-83-2. Molecular formula: C15H17IN2O2S. Mole weight: 416.28. |  |
| ML 786 dihydrochloride | ML 786 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1237536-18-3. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| ML 786 dihydrochloride | ML786 dihydrochloride is a Raf kinase inhibitor with IC50 values are 2.1, 2.5 and 4.2 nM for B-RafV600E, C-Raf and wild-type B-Raf respectively. It may be used in novel cancer therapies in the future. Synonyms: MLN786 Dihydrochloride; MLN-786 Dihydrochloride; MLN 786 Dihydrochloride; MLN786 2HCl; MLN-786 2HCl; MLN 786 2HCl; 3-(1-Amino-1-methylethyl)-N-[(2R)-1,2,3,4-tetrahydro-7-oxo-1,8-naphthryridin-4-yl)oxy]-2-naphthalenyl]-5-benzamide dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1237536-18-3. Molecular formula: C29H29F3N4O3.2HCl. Mole weight: 611.48. | |
| ML-792 | ML-792 is a potent and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays (IC50 values of 3 and 11 nM, respectively) compared with NAE/NEDD8 and UAE/ubiquitin (IC50> values of 32 ?M and >100 ?M, respectively)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1644342-14-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108702. |  |
| ML 7 hydrochloride | ML 7 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 110448-33-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML-7 hydrochloride | ML-7 Hcl is a cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM). It also inhibt smooth-muscle myosin light chain kinase, protein kinase C (PKC) and cAMP-dependent protein kinase (PKA). Synonyms: ML-7 HCl; ML-7 hydrochloride; ML-7; ML 7; ML7. Grades: >98%. CAS No. 110448-33-4. Molecular formula: C15H18ClIN2O2S. Mole weight: 452.74. | |
| ML-7 hydrochloride | ML-7 hydrochloride is a naphthalene sulphonamide derivative, potently inhibits MLCK ( IC 50 =300 nM). ML-7 hydrochloride also inhibits YAP/TAZ. Uses: Scientific research. Group: Signaling pathways. CAS No. 110448-33-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15417. | |
| ML-7, Hydrochloride - CAS 110448-33-4 | A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM). Group: Fluorescence/luminescence spectroscopy. |  |
| ML-9 | ?99% (TLC), powder. Group: Fluorescence/luminescence spectroscopy. | |
| ML-9 | ML-9 is a selective and potent inhibitor of Akt kinase , inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity [3]. ML-9 inhibits inhibits MLCK, PKA and PKC activity with K i values of 4, 32 and 54 μM, respectively [1]. ML-9 induces autophagy by stimulating autophagosome formation and inhibiting their degradation [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 105637-50-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-100932. | |
| ML-9 | ML-9 is a myosin light chain kinase (MLCK) inhibitor. It enhances the anticancer activity of docetaxel and has potential application as an adjuvant to existing anticancer chemotherapy. It is used as an attractive tool for targeting autophagy in cancer therapy through dual inhibition of both the Akt pathway and the autophagy. Uses: Ml-9 has potential application as an adjuvant to existing anticancer chemotherapy. Synonyms: ML9; ML 9; 1H-1,4-Diazepine, 1-[(5-chloro-1-naphthalenyl)sulfonyl]hexahydro-. Grades: >98%. CAS No. 110448-31-2. Molecular formula: C15H17ClN2O2S. Mole weight: 324.82. | |
| ML 9 hydrochloride | ML 9 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 105637-50-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML-9 hydrochloride | ML-9 hydrochloride is a myosin light chain kinase (MLCK) inhibitor. It enhances the anticancer activity of docetaxel and may be used as an adjuvant to existing anticancer chemotherapy. It inhibits natural killer (NK) cell activity in a dose-dependent manner without affecting target cell binding. It inhibits insulin-induced translocation of both GLUT4 and GLUT1 in a dose-dependent manner. It also inhibits agonist-induced Ca2+ entry into endothelial cells and catecholamine secretion in intact and permeabilized chromaffin cells. It inhibits the catalytic activities of several protein kinases competitively with respect to ATP and exhibited different Ki values toward each protein kinase. It may be a new type of vascular relaxant. Uses: Ml-9 hydrochloride may be used as an adjuvant to existing anticancer chemotherapy. it may be a new type of vascular relaxant. Synonyms: ML9; ML-9; ML 9; ML9 Hydrochloride;ML 9 Hydrochloride; 1-(5-Chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine HCl;1-(5-Chloronaphthalen-1-yl)sulfonyl-1,4-diazepane hydrochloride. Grades: 95%. CAS No. 105637-50-1. Molecular formula: C15H18Cl2N2O2S. Mole weight: 361.29. | |
| ML-9, Hydrochloride - CAS 105637-50-1 | A cell-permeable, reverisible and ATP-competitive inhibitor of myosin light chain kinase (Ki = 3.8 μM), protein kinase A (Ki = 32 μM), and protein kinase C (Ki = 54 μM). Group: Fluorescence/luminescence spectroscopy. | |
| MLCK (1425-1776), active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| MLCK inhibitor peptide | MLCK inhibitor peptide. Group: Biochemicals. Grades: Purified. CAS No. 198694-74-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Mlck inhibitor peptide 18 | MLCK inhibitor peptide 18 is a myosin light chain kinase (MLCK) inhibitor with an IC50 of 50 nM, and inhibits CaM kinase II only at 4000-fold higher concentrations. Uses: Designed for use in research and industrial production. Additional or Alternative Names: H-RKKYKYRRK-NH2;MYOSIN LIGHT CHAIN KINASE INHIBITOR PEPTIDE 18;MLCK INHIBITOR PEPTIDE 18. Product Category: Inhibitors. CAS No. 224579-74-2. Molecular formula: C60H105N23O11. Mole weight: 1324.62. Purity: 0.9966. Product ID: ACM224579742. Alfa Chemistry ISO 9001:2015 Certified. |  |
| MLCK inhibitor peptide 18 | MLCK inhibitor peptide 18. Group: Biochemicals. Grades: Purified. CAS No. 224579-74-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| MLCK inhibitor peptide 18 | A myosin light chain kinase (MLCK) inhibitor (IC50= 50 nM), and inhibits CaM kinase IIonly at 4000-fold higher concentrations. Synonyms: Myosin Light Chain Kinase Inhibitor Peptide 18. Grades: ≥95%. CAS No. 224579-74-2. Molecular formula: C60H105N23O11. Mole weight: 1324.64. | |
| MLCK inhibitor peptide 18 | MLCK inhibitor peptide 18 is a myosin light chain kinase ( MLCK ) inhibitor with an IC 50 of 50 nM, and inhibits CaM kinase II only at 4000-fold higher concentrations. Uses: Scientific research. Group: Peptides. CAS No. 224579-74-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P1029. | |
| MLCK inhibitor peptide 18 acetate | MLCK inhibitor peptide 18 acetate is a selective competitive myosin light chain kinase (MLCK) inhibitor (IC50 = 50 nM) that inhibits CaM kinase II only at 4000-fold higher concentrations. Synonyms: H-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH2.CH3CO2H; L-arginyl-L-lysyl-L-lysyl-L-tyrosyl-L-lysyl-L-tyrosyl-L-arginyl-L-arginyl-L-lysinamide acetate. Grades: ≥95%. Molecular formula: C62H109N23O13. Mole weight: 1384.67. | |
| MLH3 protein, partial (135-151) | MLH3 protein, partial (135-151) is a 7-aa peptide. MLH3 is a DNA mismatch repair gene associated with mammalian microsatellite instability. | |
| MLi-2 | MLi-2 is a potent, orally available and brain penetrant inhibitor of LRRK2 (IC50 = 0.76 nM) with excellent selectivity that shows >295-fold selectivity for over 300 kinases and a diverse panel of receptors and ion channels. Synonyms: (2R,6S)-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1H-indazol-3-yl]pyrimidin-4-yl]morpholine; MLi-2; MLi 2; MLi2. CAS No. 1627091-47-7. Molecular formula: C21H25N5O2. Mole weight: 379.46. | |
| MLi-2 | MLi-2 is an orally active and highly selective LRRK2 inhibitor with an IC50 of 0.76 nM. MLi-2 has the potential for Parkinsons disease[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1627091-47-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100411. | |
| MLK1 (1-433), active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| MLK2 (1-446), active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| MLK3 (1-488), active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| MLKL Inhibitor, Necrosulfonamide ((E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide, Mixed Lineage Kinase Domain-like Protein Inhibitor, Necrosome Inhibitor II, Necrosulfonamide) | A cell-permeable acrylamide compound that inhibits human, but not murine, MLKL adaptor function via covalent modification of Cys86 and is more potent than Nec-1 in preventing necrotic/necroptotic death in human HT-29 (IC50 = 124nM and 2uM, respectively), being ineffective against necrosis/necroptosis in murine L929 or apoptosis in human RIP3-null Panc-1 cells. Unlike Nec-1, which prevents necrosome formation by blocking RIP1-RIP3 interaction, MLKL prevents the MLKL-RIP1-RIP3 necrosome complex from interacting with further downstream effectors. Group: Biochemicals. Grades: Highly Purified. CAS No. 432531-71-0. Pack Sizes: 25mg. Molecular Formula: C??H??N?O?S?, Primary Target: human MLKL. US Biological Life Sciences. | Worldwide |
| MLL1/WDR5/Ash2L/RbBP5/DPY30 human | recombinant, expressed in E. coli, ?83% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| MLL1/WDR5/Ash2L/RbBP5 human | recombinant, expressed in E. coli, ?83% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| MLN0128 | MLN0128, also known as INK128, is a TORC1/2 inhibitor, is also an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity. TORC1/2 inhibitor INK128 binds to and inhibits both TORC1 and TORC2 complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. TORC1 and 2 are upregulated in some tumors and play an important role in the PI3K/Akt/mTOR signaling pathway, which is frequently dysregulated in human cancers. Synonyms: TAK-228; TAK 228; TAK228; INK128; INK-128; INK 128; MLN0128; MLN 0128; MLN-0128; Sapanisertib. Grades: >98%. CAS No. 1224844-38-5. Molecular formula: C15H15N7O. Mole weight: 309.333. | |
| MLN0905 | MLN0905 is a potent, orally active Polo-like kinase 1 (PLK1) inhibitor. MLN0905 has inhibitory potency against PLK1 with an IC50 value of 2 nM. MLN0905 can be used for the research of cancer[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1228960-69-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15155. | |
| MLN0905 | MLN0905 is a potent, selective small-molecule PLK1 inhibitor. MLN0905 inhibits cell proliferation in a broad range of human tumor cells including DLBCL cell lines. PLK1 inhibition leads to pharmacodynamic pHisH3 modulation and significant antitumor activity in multiple DLBCL models. These data strongly suggest evaluating PLK1 inhibitors as DLBCL anticancer agents in the clinic. Synonyms: MLN0905; MLN0905; MLN0905. CAS No. 1228960-69-7. Molecular formula: C24H25F3N6S. Mole weight: 486.561. | |
| MLN1117 | MLN1117, also known as INK1117, is a PI3Kα inhibitor which could lead to the apoptosis and growth retardation of tumor cells expressed by PI3K&alpha. IC50: 15 nM. Uses: Mln1117 is a pi3kα inhibitor which could lead to the apoptosis and growth retardation of tumor cells expressed by pi3k&alpha. Synonyms: INK1117; INK-1117; INK 1117; MLN1117; MLN 1117; MLN-1117; TAK-117; TAK 117; TAK117; Serabelisib; [6-(2-amino-1,3-benzoxazol-5-yl)imidazo[1,2-a]pyridin-3-yl]-morpholin-4-ylmethanone;Serabelisib. Grades: 98%. CAS No. 1268454-23-4. Molecular formula: C19H17N5O3. Mole weight: 363.37. | |
| MLN120B | MLN120B (ML120B) is a potent, ATP competitive, and orally active inhibitor of IKK? with an IC50 of 60 nM. MLN120B inhibits multiple myeloma cell growth in vitro and in vivo and also can be used for the research of rheumatoid arthritis[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ML120B. CAS No. 783348-36-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15473. | |
| MLN120B | MLN120B is a potent and effective IKKbeta inhibitor. It is currently being explored for treatment of inflammatory diseases such as COPD and asthma. Synonyms: MLN-120B; MLN120B; MLN 120B. Grades: >98%. CAS No. 783348-36-7. Molecular formula: C19H15ClN4O2. Mole weight: 366.8. | |
| MLN2480 | MLN2480 is an oral, selective pan-Raf kinase inhibitor. The Raf kinases (A-Raf, B-Raf and C-Raf) are key regulators of cell proliferation and survival within the mitogen-activated protein kinase (MAPK) pathway. The MAPK pathway is frequently disregulated in human cancers, often via activating mutations of Ras or Raf. Synonyms: TAK-580; TAK 580; TAK580; MLN 2480; MLN-2480; MLN2480; AMG 2112819; AMG2112819; AMG-2112819. Grades: >98%. CAS No. 1096708-71-2. Molecular formula: C17H12Cl2F3N7O2S. Mole weight: 506.29. | |
| MLN-4760 | MLN-4760 is a potent and selective human ACE2 inhibitor (IC50, 0.44 nM), with excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 ?M) and bovine carboxypeptidase A (CPDA; IC50, 27 ?M). Uses: Scientific research. Group: Signaling pathways. CAS No. 305335-31-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-19414. | |
| MLN 4924 | A potent and selective inhibitor of NAE. Group: Biochemicals. Alternative Names: Sulfamic Acid [ (1S, 2S, 4R) -4- [4- [ [ (1S) -2, 3-dihydro-1H-inden-1-yl] amino] -7H-pyrrolo [2, 3-d] pyrimidin-7-yl] -2-hydroxycyclopentyl] methyl Ester. Grades: Highly Purified. CAS No. 905579-51-3. Pack Sizes: 1mg, 2mg, 5mg, 10mg. US Biological Life Sciences. | Worldwide |
| MLN4924 HCl | MLN4924 HCl is a potent and selective small molecule NEDD8-activating enzyme (NAE) inhibitor with an IC50 of 4.7 nM. Synonyms: MLN4924 HCl; MLN 4924 HCl; MLN-4924 HCl. Grades: >98%. CAS No. 1160295-21-5. Molecular formula: C21H26ClN5O4S. Mole weight: 479.98. | |
| MLN8054 | MLN8054 is a potent, selective and orally available aurora A kinase inhibitor with an IC 50 of 4 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 869363-13-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10180. | |
| MLN8054 | MLN8054 is an aurora kinase inhibitor MLN8054, which is an orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase with potential antineoplastic activity. Auora kinase inhibitor MLN8054 binds to and inhibits Aurora kinase A, resulting in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregration, and inhibition of cell proliferation. Aurora A localizes in mitosis to the spindle poles and to spindle microtubules and is thought to regulate spindle assembly. Aberrant expression of Aurora kinases occurs in a wide variety of cancers, including colon and breast cancers. Synonyms: MLN8054; MLN 8054; MLN-8054. CAS No. 869363-13-3. Molecular formula: C25H15ClF2N4O2. Mole weight: 476.86. | |
| MLN 8054 | An Aurora kinase inhibitor, used to treat patients with advanced solid tumors. Group: Biochemicals. Alternative Names: 4-[[9-Chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic Acid. Grades: Highly Purified. CAS No. 869363-13-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| MLN 8237 | Antagonist of Aurora A serine/threonine protein kinase; antineoplastic. Group: Biochemicals. Alternative Names: 4-[[9-Chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxy-benzoic acid; Alisertib. Grades: Highly Purified. CAS No. 1028486-01-2. Pack Sizes: 10mg. Molecular Formula: C27H20ClFN4O4, Molecular Weight: 518.92. US Biological Life Sciences. | Worldwide |
| MLN-9708 | ixazomib is an orally bioavailable second generation proteasome inhibitor (PI) with potential antineoplastic activity. Ixazomib inhibits the activity of the proteasome, blocking the targeted proteolysis normally performed by the proteasome, which results in an accumulation of unwanted or misfolded proteins; disruption of various cell signaling pathways may follow, resulting in the induction of apoptosis. Compared to first generation PIs, second generation PIs may have an improved pharmacokinetic profile with increased potency and less toxicity. Proteasomes are large protease complexes that degrade unneeded or damaged proteins that have been ubiquinated. Synonyms: Ixazomib; MLN-9708; MLN 9708; MLN9708. CAS No. 1201902-80-8. Molecular formula: C20H23BCl2N2O9. Mole weight: 517.12. | |
| M-Loxoprofen | M-Loxoprofen. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1026471-88-4. Molecular formula: C15H18O3. Mole weight: 246.31. Catalog: APB1026471884. | |
| MLR 1023 | MLR 1023. Group: Biochemicals. Grades: Purified. CAS No. 41964-07-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| MLR 1023 | Tolimidone is an allosteric Lyn kinase activator with EC50 value of 63 nM. It has been shown to reduce blood glucose levels in mice. Synonyms: Tolimidone; CP 26,154; CP 26,154; CP 26,154; NSC 314335; MLR-1023; MLR 1023; MLR1023. 5-(3-Methylphenoxy)-2(1H)-pyrimidinone. Grades: ≥99% by HPLC. CAS No. 41964-07-2. Molecular formula: C11H10N2O2. Mole weight: 202.21. | |
| MLR-52 | MLR-52, extracted from Streptomyces sp. AB 1869R-359, is an immunosuppressive protein kinase C inhibitor. And the IC50 (nmol/L) of the mixed lymphocyte response test was 1.9±0.2. Synonyms: 4'-Demethylamino-4',5'-dihydroxystaurosporine; (+)-MLR-52. CAS No. 155416-34-5. Molecular formula: C27H23N3O5. Mole weight: 469.49. | |
| ML RR-S2 CDA | ML RR-S2 CDA, a synthetic CDN-derivative molecule, compared to endogenous and pathogen-derived CDNs, as a attractive compound for anticancer clinical development, it improves both stability and lipophilicity, promoting significantly increased STING signal. Synonyms: 2',3'-c-di-AM(PS)2(Rp,Rp); Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'?5')-, cyclic nucleotide; (R,R)-(2',3')c-diAM(PS)2; (2',3')-Rp,Rp-c-diAMPSS; dithio-(RP, RP)-[cyclic[A(2',5')pA(3',5')p]]; ML RR-S2 CDA (STING-Inducer-1). Grades: ≥95%. CAS No. 1638241-89-0. Molecular formula: C20H24N10O10P2S2. Mole weight: 690.54. | |
| ML RR-S2 CDA sodium salt | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| MLS0315771 | MLS0315771 is a potent and biologically active competitive phosphomannose isomerase (MPI) inhibitor, with an IC50 ~1 ?M and a Ki of 1.4 ?M. Uses: Scientific research. Group: Signaling pathways. CAS No. 727664-91-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112945. | |
| MLS1547 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| MLS1547 | MLS1547 is a highly efficacious D2 dopamine receptor (D2R) G protein-biased agonist that does not recruit β-arrestin, and is an antagonist of dopamine-stimulated β-arrestin recruitment to the D2 receptor. Uses: Designed for use in research and industrial production. Additional or Alternative Names: MLS1547; MLS-1547; MLS 1547; MLS000051547. Product Category: Agonists. Appearance: Solid powder. CAS No. 315698-36-3. Molecular formula: C19H19ClN4O. Mole weight: 354.84. Purity: >98%. IUPACName: 5-Chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol. Canonical SMILES: OC1=C2N=CC=CC2=C(Cl)C=C1CN3CCN(C4=NC=CC=C4)CC3. Product ID: ACM315698363. Alfa Chemistry ISO 9001:2015 Certified. | |
| MLS 1547 | MLS 1547 is a dopamine D2 receptor agonist. It may be used in the combination with antipsychotic drugs. Synonyms: MLS 1547; MLS1547; MLS-1547; 5-Chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol. Grades: ≥98% by HPLC. CAS No. 315698-36-3. Molecular formula: C19H19ClN4O. Mole weight: 354.83. | |
| MLS-573151 | MLS-573151 is a specific and cell-permeable inhibitor of Cdc42, a GTPase of the Rho family. Synonyms: 4-(3,5-Diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide. Grades: ≥98%. CAS No. 10179-57-4. Molecular formula: C21H19N3O2S. Mole weight: 377.5. | |
| ML SA1 | ML SA1. Group: Biochemicals. Grades: Purified. CAS No. 332382-54-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML SA1 | ML SA1 is an activator of TRPML channels. It can induce TRPML-mediated Ca2+ release from lysosomes and reduce cholesterol accumulation in Niemann-Pick type C macrophages. Synonyms: 2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione. Grades: ≥99% by HPLC. CAS No. 332382-54-4. Molecular formula: C22H22N2O3. Mole weight: 362.42. | |
| ML-SA1 | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML-SA1 | ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 ?M and 52.99 ?M, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 332382-54-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-108462. | |
| ML-SA5 | ML-SA5 is a potent TRPML1 cation channel agonist that activates the entire endosomal TRPML1 (ML1) current in DMD myocytes with an EC50 of 285 nM and is more potent than ML-SA1. ML-SA5 has anticancer activity and can inhibit tumour growth[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2418670-70-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-152182. | |
| ML-SI1 | ML-SI1, a racemic mixture of diastereomers, is a TRPML inhibitor with an IC50 value of 15 ?M for TRPML1[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134818. | |
| ML-SI3 | ML-SI3 is a mixture of cis/trans ML-SI3 (HY-139426A), which is a TRPML1/2 channel inhibitor with IC50s of 4.7 ?M and 1.7 ?M, respectively. ML-SI3 also inhibits lysosomal calcium efflux and blocks downstream TRPML1-mediated autophagy. The cis/trans ML-SI3 (HY-139426A) components of ML-SI3 are TRPML2 activators with EC50s of 3.3 ?M and 9.4 ?M, respectively[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ML-SI3 (cis/trans mix). CAS No. 891016-02-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139426. | |
| ML-SI3 | ML-SI3 is a chemical compound which acts as an "antagonist" (i.e. channel blocker) of the TRPML family of calcium channels, with greatest activity at the TRPML1 channel, although it also blocks the related TRPML2 and TRPML3 channels with lower affinity. It is used for research into the role of TRPML1 and its various functions in lysosomes and elsewhere in the body. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ML-SI3; ML SI3; MLSI3; ML SI 3; MLSI-3. Product Category: Antagonists. Appearance: Solid powder. CAS No. 891016-02-7. Molecular formula: C23H31N3O3S. Mole weight: 429.58. Purity: >98%. IUPACName: N-(2-[4-(2-Methoxyphenyl)-1-piperazinyl]cyclohexyl)benzenesulfonamide. Canonical SMILES: O=S(C1=CC=CC=C1)(NC2C(N3CCN(C4=CC=CC=C4OC)CC3)CCCC2)=O. Product ID: ACM891016027. Alfa Chemistry ISO 9001:2015 Certified. | |
| ML-SI3 | ML-SI3 is an antagonist of the TRPML family of calcium channels. ML-SI3 can prevent lysosomal calcium efflux and has been reported to block downstream TRPML1-mediated induction of autophagy. Synonyms: N- [2- [4- (2-methoxyphenyl) -1-piperazinyl] cyclohexyl] benzenesulfonamide. CAS No. 891016-02-7. Molecular formula: C23H31N3O3S. Mole weight: 429.58. | |
| MLT-747 | MLT-747 is a potent and selective malt1 peptide cleavage inhibitor. Synonyms: AC-31545; HY-124587; MLT 747; MLT747. Grades: ≥98% by HPLC. CAS No. 2097853-86-4. Molecular formula: C20H21Cl2N7O3. Mole weight: 478.3. | |
| MLT-748 | MLT-748 is a potent and selective malt1 peptide cleavage inhibitor. Synonyms: 1-(5-Chloro-6-(2H-1,2,3-Triazol-2-Yl)Pyridin-3-Yl)-3-(2-Chloro-7-((1R,2R)-1,2-Dimethoxypropyl)Pyrazolo[1,5-A]Pyrimidin-6-Yl)Urea. Grades: ≥98% by HPLC. CAS No. 1832578-30-9. Molecular formula: C19H19Cl2N9O3. Mole weight: 492.3. | |
| Mlu I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 20-fold overdigestion with enzyme 95% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 1000U; 5000U. A↑CGCGT TGCGC↓A. Activity: 20000u.a./ml. Appearance: 10 X SE-buffer O. Storage: -20°C. Form: Liquid. Source: Micrococcus luteus. Pack: 10 mM Tris-HCl (pH 7.5); 100 mM NaCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1133RE. |  |
| Mly113 I | One unit of the enzyme is the amount required to hydrolyze 1 μg of T7 DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 3-fold overdigestion with enzyme more than 80% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 200U; 1000U. GG↑CGCC CCGC↓GG. Activity: 2000u.a./ml. Appearance: 10 X SE-buffer B. Storage: -20°C. Form: Liquid. Source: Micrococcus lylae 113. Pack: 10 mM Tris-HCl (pH 7.5); 50 mM KCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1134RE. | |
| MM0299 | MM0299 is an inhibitor for lanosterol synthase (LSS) with an IC50 of 2.2 ?M. MM0299 inhibits cell proliferation of Mut6 with an IC50 of 0.0182 ?M, through generation of 24(S),25-epoxycholesterol (EPC) and the depletion of cellular cholesterol[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 474255-10-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160972. | |
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