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| Product | Description | |
|---|---|---|
| ML099 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| ML-099 | ML-099 is a pan activator of Ras-related GTPases. Synonyms: ML 099; ML099; CID-888706; 2-[(2-Phenylethyl)thio]nicotinic acid. Grades: ≥98%. CAS No. 496775-95-2. Molecular formula: C14H13NO2S. Mole weight: 259.3. |  |
| ML-10 | ML-10 is a small molecule apoptosis probe. Due to the presence of fluorine atoms, ML-10 can be radiolabeled with 18 F isotopes and can be used for apoptosis positron emission tomography imaging studies. ML-10 is selectively taken up and accumulated in apoptotic cells, while being excluded from live or necrotic cells. In addition, the uptake of ML-10 is associated with apoptotic features such as caspase activation, Annexin-V binding, and disruption of mitochondrial membrane potential [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1216897-16-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-76573. |  |
| ML 10302 | ML 10302 is a potent agonist 5-HT4 receptor with K i of 1.07 nM. 5-Hydroxytryptamine (5-HT4) receptor agonists stimulate gut motility through cholinergic pathways. ML10302 induces significant prokinesia both in the small bowel and colon through activation of cholinergic pathways. ML 10302 also has the potential for the research of neurology diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 148868-55-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14441. | |
| ML 10302 | ?98%, solid. Group: Fluorescence/luminescence spectroscopy. | |
| ML 10302 hydrochloride | ML 10302 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 186826-17-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| ML 10302 hydrochloride | ML 10302 hydrochloride is a 5-HT4 agonist with EC50 value of 4 nM. It can increase sAPPα levels in the cortex in an animal model of Alzheimer's disease and exhibit progastrokinetic effects in vivo. Synonyms: ML-10302 HCl; ML-10302; ML 10302; ML10302. 4-Amino-5-chloro-2-methoxybenzoic acid 2-(1-piperidinyl)ethyl ester hydrochloride. Grades: ≥99% by HPLC. CAS No. 186826-17-5. Molecular formula: C15H21ClN2O3.HCl. Mole weight: 349.25. | |
| ML115 | ML115 is a molecular probe of the signal transducer and activator of transcription ( STAT3 ). ML115 is a STAT3 agonist [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 912798-42-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-111152. | |
| ML-115 | ML-115 is a potent, cell-permeable STAT3 activator with EC50 value of 2 nM. It is inactive against the related STAT1 and NFκB anti-targets. ML-115 exhibits no cytotoxicity in the parental cell lines in the STAT3 assay (HT-1080) and STAT1 assay (NIH-3T3). Synonyms: ML115; ML 115; 3-Isoxazolecarboxamide, N-(4-chloro-2,5-dimethoxyphenyl)-5-cyclopropyl-; N-(4-Chloro-2,5-dimethoxyphenyl)-5-cyclopropyl-3-isoxazolecarboxamide. Grades: ≥98%. CAS No. 912798-42-6. Molecular formula: C15H15ClN2O4. Mole weight: 322.74. | |
| ML116 | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML120B | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML 120B dihydrochloride | ML 120B dihydrochloride is an ATP-competitive IKK2-selective inhibitor with IC50 value of 60 nM at 50 μM ATP. It can inhibit paw swelling, bone and cartilage degradation. Synonyms: ML 120B dihydrochloride; ML120B dihydrochloride; ML-120B dihydrochlorideN-(6-Chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methyl-3-pyridinecarboxamide dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1782573-78-7. Molecular formula: C19H15ClN4O2.2HCl. Mole weight: 439.72. | |
| ML 120B dihydrochloride | ML 120B dihydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML130 | ML130 (Nodinitib-1) is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM, inhibits NF-κB activation, exhibits 36-fold selectivity over NOD2. Synonyms: ML 130; ML-130; Nodinitib-1; Noditinib-1; 1-Tosyl-1H-benzo[d]imidazol-2-amine. Grades: >98%. CAS No. 799264-47-4. Molecular formula: C14H13N3O2S. Mole weight: 287.34. | |
| ML 130 | ML 130. Group: Biochemicals. Grades: Purified. CAS No. 799264-47-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML-132 | ML132, also known as CID-4462093 or NCGC-00183434, is the most potent caspase 1 inhibitor reported to date. It also possesses a unique selectivity pattern relative to other reported caspase inhibitors. Synonyms: NCGC 00185682; ML132; ML 132; N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(1S)-2-carboxy-1-cyanoethyl]-L-prolinamide; L-Prolinamide, N-(4-amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(1S)-2-carboxy-1-cyanoethyl]-. Grades: ≥98%. CAS No. 1230628-71-3. Molecular formula: C22H28ClN5O5. Mole weight: 477.94. | |
| ML133 HCl | ML133 HCl is a selective potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1. Synonyms: ML133 hydrochloride; (4-Methoxybenzyl)(1-naphthylmethyl)amine Hydrochloride; N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride. Grades: >98%. CAS No. 1222781-70-5. Molecular formula: C19H19NO.HCl. Mole weight: 313.82. | |
| ML 133 hydrochloride | ML 133 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1222781-70-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML133 hydrochloride | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML133 hydrochloride | ML133 hydrochloride is a selective K ir 2 family channels inhibitor, with an IC 50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1222781-70-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100230A. | |
| ML138 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML141 | ML141 is a potent, selective and reversible non-competitive inhibitor of Rho family GTPase cdc42 with IC50 of 200 nM. Synonyms: Ro111163; Ro-111163; Ro 111163; ML-141; ML 141; ML141; CID2950007; CID-2950007; CID 2950007. Grades: >98%. CAS No. 71203-35-5. Molecular formula: C22H21N3O3S. Mole weight: 407.49. | |
| ML141 | ML141 (CID-2950007) is a potent, allosteric, selective and reversible non-competitive inhibitor of Cdc42 GTPase. ML141 inhibits Cdc42 wild type and Cdc42 Q61L mutant with EC50s of 2.1 and 2.6 ?M, respectively. ML141 shows low micromolar potency and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 do not show cytotoxicity in multiple cell lines[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CID-2950007. CAS No. 71203-35-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12755. | |
| ML 141 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML 141 | ML 141. Group: Biochemicals. Grades: Purified. CAS No. 71203-35-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 145 | ML 145. Group: Biochemicals. Grades: Purified. CAS No. 1164500-72-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 145 | ML 145 is a GPR35 orphan receptor antagonist with IC50 value of 20.1 nM. It can be used in the treatment of disorders affecting the stomach as well as the immune system. Synonyms: ML 145; ML145; ML-145; 2-Hydroxy-4-[4-(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoylamino]benzoic acid. Grades: ≥98% by HPLC. CAS No. 1164500-72-4. Molecular formula: C24H22N2O5S2. Mole weight: 482.57. | |
| ML-148 | ML-148 is a potent and selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH). Synonyms: ML 148; ML148; [1-(3-methylphenyl)benzimidazol-5-yl]-piperidin-1-ylmethanone. Grades: ≥98%. CAS No. 451496-96-1. Molecular formula: C20H21N3O. Mole weight: 319.4. | |
| ML 154 | ML 154. Group: Biochemicals. Grades: Purified. CAS No. 1345964-89-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 154 | ML 154 is a neuropeptide S receptor antagonist. It has the potential to be used in the treatment of sleep, anxiety and addiction disorders. Synonyms: NCGC 84; NCGC84; NCGC-84; ML 154; ML154; ML-154; NCGC00185684. 3-(Diphenylphosphinothioyl)-2-methyl-1-[(2E)-3-phenyl-2-propen-1-yl]imidazo[1,2-a]pyridinium bromide. Grades: ≥99% by HPLC. CAS No. 1345964-89-7. Molecular formula: C29H26N2PS.Br. Mole weight: 545.47. | |
| ML 161 | ML 161 is a diaminobenzene derivative that acts as a selective inhibitor of platelet activation at protease-activated receptor 1 (PAR1). ML 161 has also been shown to inhibit thrombin-induced platelet activation. Group: Biochemicals. Alternative Names: ML161; 2-Bromo-N- [3- [ (1-oxobutyl) amino] phenyl] benzamide. Grades: Highly Purified. CAS No. 423735-93-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| ML 161 | Inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50 = 0.26 muM for the inhibition of platelet P-selectin expression on human platelets). Thought to act allosterically. Also inhibits thrombin-induced platelet activation. Synonyms: ML-161; ML161; Parmodulin 2; 2-Bromo-N-[3-[(1-oxobutyl)amino]phenyl]benzamide. CAS No. 423735-93-7. Molecular formula: C17H17BrN2O2. Mole weight: 361.24. | |
| ML-161 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML162 | ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. ML162 has a selective lethal effect on mutant RAS oncogene-expressing cell lines[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1035072-16-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-100002. | |
| ML162 | ML162 Inhibitor. Uses: Scientific use. Product Category: T8970. CAS No. 1035072-16-2. |  |
| ML-162 | ML-162 is a GPX4 inhibitor that selectively kills cells induced to express mutant RAS. GPX4 is a regulator of ferroptosis (iron-dependent, non-apoptotic cell death). Synonyms: ML 162; ML162; 2-[(Chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide. Grades: ≥95%. CAS No. 1035072-16-2. Molecular formula: C23H22Cl2N2O3S. Mole weight: 477.4. | |
| ML167 | ML167 is the first highly selective inhibitor of of Cdc2-like kinase 4 (Clk4) with an IC50 of 136 nM for Clk4. The Cdc2-like kinases (Clk 's) and the dual-specificity tyrosine phosphorylation-regulated kinases (Dyrk 's) have specified roles in gene splicing. Specifically, the Clk class of enzymes has been shown to phosphorylate the serine- and arginine-rich (SR) proteins, which are a major component of the spliceosome. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ML167; ML-167; ML 167; CID 44968231; CID44968231; CID-44968231; NCGC00188654; NCGC-00188654; NCGC 00188654. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1285702-20-6. Molecular formula: C19H17N3O3. Mole weight: 335.36. Purity: >98%. IUPACName: (5-(4-(((5-methylfuran-2-yl)methyl)amino)quinazolin-6-yl)furan-2-yl)methanol. Canonical SMILES: OCC1=CC=C(C2=CC3=C(NCC4=CC=C(C)O4)N=CN=C3C=C2)O1. Product ID: ACM1285702206. Alfa Chemistry ISO 9001:2015 Certified. Categories: M167 VADS. |  |
| ML167 | ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B. Synonyms: CID44968231; NCGC00188654; [5-[4-[(5-methyl-2-furanyl)methylamino]-6-quinazolinyl]-2-furanyl]methanol; 2-Furanmethanol, 5-[4-[[(5-methyl-2-furanyl)methyl]amino]-6-quinazolinyl]-. Grades: >98%. CAS No. 1285702-20-6. Molecular formula: C19H17N3O3. Mole weight: 335.36. | |
| ML167 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML169 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML171 | ML171 (2-Acetylphenothiazine;2-APT) is a potent and selective NADPH oxidase 1 (Nox1) inhibitor that blocks Nox1-dependent ROS generation, with an IC50 of 0.25 ?M in HEK293-Nox1 confirmatory assay. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2-Acetylphenothiazine; 2-APT. CAS No. 6631-94-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-12805. | |
| ML 171 | ML 171. Group: Biochemicals. Grades: Purified. CAS No. 6631-94-3. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| ML-178 | ML-178 is a selective S1P4 activator with EC50 value of 46.3 nM without effect against S1P1, S1P2, S1P3, and S1P5. Synonyms: ML 178; ML178; CID 44620892; CYM 50179; SID 87544119; 2,6-dibromo-3-[2-(2,4-dichlorophenoxy)ethoxy]pyridine. Grades: ≥95%. CAS No. 1355026-47-9. Molecular formula: C13H9Br2Cl2NO2. Mole weight: 441.9. | |
| ML 179 | ML 179 is a liver receptor homolog 1 inverse agonist with IC50 value of 320 nM. Synonyms: ML 179; ML179; ML-179; 3-Cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1H-pyrimidine-2,4-dione. Grades: ≥99% by HPLC. CAS No. 1883548-87-5. Molecular formula: C21H25F3N4O2. Mole weight: 422.44. | |
| ML 179 | ML 179. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 18 | ML 18 is a bombesin receptor subtype 3 (BRS-3) antagonist (IC50 = 4.8 μM) and binds GRPR (IC50 = 16 μM) with potential in combating lung cancer cells. Synonyms: ML-18; ML 18; ML18. 1H-Indole-3-propanamide, N-[[1- (4-methoxyphenyl) ?cyclohexyl]?methyl]?-α -[[[ (4-nitrophenyl) ?amino]?carbonyl]?amino]?-, (αS)?-; (αS)-N-[[1-(4-Methoxyphenyl)cyclohexyl]methyl]-α-[[[(4-nitrophenyl)amino]carbonyl]amino]-1H-indole-3-propanamide. CAS No. 1422269-30-4. Molecular formula: C32H35N5O5. Mole weight: 569.65. | |
| ML-180 | ML-180 is an inverse agonist of liver receptor homolog-1 (LRH-1) that inhibits cell proliferation. Synonyms: ML 180; ML180; CID-3238389; SR1848; 6-[4-(3-Chlorophenyl)-1-piperazinyl]-3-cyclohexyl-1H-pyrimidine-2,4-dione. Grades: ≥98%. CAS No. 863588-32-3. Molecular formula: C20H25ClN4O2. Mole weight: 388.9. | |
| ML-180 | ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2 ) inverse agonist with an IC 50 of 3.7 μM. ML-180 is inactive for steroidogenic factor-1 (SF-1; NR5A1 ; IC 50 >10 μM). ML-180 has the potential for LRH-1-dependent cancers [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SR1848. CAS No. 863588-32-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-115613. | |
| ML188 | ML188, a first in class probe, is a selective non-covalent SARS-CoV 3CLpro inhibitor with an IC50 of 1.5 μM. Antiviral activity. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (R)-N-(4-(tert-Butyl)phenyl)-N-(2-(tert-butylamino)-2-oxo-1-(pyridin-3-yl)ethyl)furan-2-carboxamide. Product Category: Inhibitors. Appearance: White to off-white solid. CAS No. 1417700-13-0. Molecular formula: C26H31N3O3. Mole weight: 433.55. Purity: 0.98. IUPACName: N-[(1R)-2-(tert-butylamino)-2-oxo-1-pyridin-3-ylethyl]-N-(4-tert-butylphenyl)furan-2-carboxamide. Canonical SMILES: CC(C)(C)C1=CC=C(C=C1)N([C@H](C2=CN=CC=C2)C(=O)NC(C)(C)C)C(=O)C3=CC=CO3. Product ID: ACM1417700130. Alfa Chemistry ISO 9001:2015 Certified. Categories: M1885 Remington-Lee. | |
| ML 190 | ML 190 is a κ opioid receptor antagonist with IC50 value of 120 nM. Synonyms: ML 190; ML190; ML-190; N-[3-[4-(4-Methoxyphenyl)-1-piperazinyl]propyl]-1-methyl-6-oxopyrido[2,3-e]pyrrolo[1,2-a]pyrazine-5(6H)-acetamide. Grades: ≥98% by HPLC. CAS No. 1355244-02-8. Molecular formula: C27H32N6O3. Mole weight: 488.58. | |
| ML 190 | ML 190. Group: Biochemicals. Grades: Purified. CAS No. 1355244-02-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML-191 | ML-191 is a GPR55 antagonist inhibiting LPI-induced phosphorylation of ERK1/2 and blocking receptor-dependent translocation of PKCβII. Synonyms: ML 191; ML191; CCG-152883; CID-23612552; 3-[1-[[1-(4-Methylphenyl)cyclopropyl]-oxomethyl]-4-piperidinyl]-5-phenyl-1,3,4-oxadiazol-2-one. Grades: ≥98%. CAS No. 931695-79-3. Molecular formula: C24H25N3O3. Mole weight: 403.5. | |
| ML192 | ML192 is a selective ligands for GPR55 with 1080 nM potency for GPR55 and >45-fold antagonist and agonist selectivity against GPR35, CB1 and CB2. Uses: Potent and selective antagonist for gpr55. Synonyms: ML192; ML 192; ML-192; CID1434953; CID-1434953; CID 1434953; MLS000526305. furan-2-yl(4-(2-methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)piperazin-1-yl)methanone. Grades: ≥98%. CAS No. 460331-61-7. Molecular formula: C20H22N4O2S. Mole weight: 382.48. | |
| ML 193 | ML 193 is a GPR55 antagonist with IC50 value of 221 nM. Synonyms: ML-193; ML 193; ML193; CID 1261822; CID-1261822; CID1261822; N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide. Grades: ≥98% by HPLC. CAS No. 713121-80-3. Molecular formula: C28H25N5O4S. Mole weight: 527.59. | |
| ML-193 | ML-193 (CID 1261822) is a potent and selective antagonist of GPR55, with an IC50 of 221 nM. ML-193 shows more than 27-fold selectivity for GPR55 over GPR35, CB1 and CB2. ML-193 can improve the motor and the sensorimotor deficits of Parkinsons disease (PD) rats[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CID 1261822. CAS No. 713121-80-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-110125. | |
| ML193 trifluoroacetate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML194 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML 202 | ML 202. Group: Biochemicals. Grades: Purified. CAS No. 1221186-52-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| ML204 | ML204 is a potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca 2+ channels [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 5465-86-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12949. | |
| ML204 | ML204 is a novel and potential TRPC4 Channel inhibitor. ML204 inhibited TRPC4β-mediated intracellular Ca(2+) rise with an IC(50) value of 0.96 μm and exhibited 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation. Synonyms: 4-Methyl-2-piperidin-1-ylquinoline; ML204; ML 204; ML-204. Grades: > 98%. CAS No. 5465-86-1. Molecular formula: C15H18N2. Mole weight: 226.323. | |
| ML204 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML 204 | ML 204. Group: Biochemicals. Grades: Purified. CAS No. 5465-86-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML204 hydrochloride | ML204 hydrochloride is a novel, potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca 2+ channels [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2070015-10-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12949A. | |
| ML 204 (Selective TRPC4 Blocker, 4-Methyl-2-(1-piperidinyl)quinoline ) | Blocker of TRPC4 channels (IC50 values are 0.96 and 2.6um in fluorescent and electrophysiological assays, respectively). Exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5; displays no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22um. Group: Biochemicals. Grades: Highly Purified. CAS No. 5465-86-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| ML 210 | ML 210 is a selective RAS inhibitor that kills cells induced to express mutant RAS. ML210 exhibits nanomolar potency against two HRASG12V expressing cell lines and 4-fold selectivity against two control cell lines not expressing HRASG12V. Synonyms: CID 49766530; CID-49766530; CID49766530; ML-210; ML 210; ML210. [4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)-methanone. Grades: 99%. CAS No. 1360705-96-9. Molecular formula: C22H20Cl2N4O4. Mole weight: 475.32. | |
| ML 210 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML-210 | ML-210 is a selective and covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 30 nM. ML-210 binds the GPX4 selenocysteine residue. ML-210 has anti-cancer activity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1360705-96-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-100003. | |
| ML-211 | ML-211 is a dual inhibitor of LYPLA1 and the related LYPLA2 with IC50 of 17 and 30 nm. ML-211 could inhibit the serine hydrolase ABHD11 with IC50 of 10 nM but was over 50-fold selective for LYPLA in a panel of 20 additional serine hydrolases. Synonyms: Methanone, [4-(1,1-dimethylethyl)-1-piperidinyl][4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl]-; [4-(1,1-Dimethylethyl)-1-piperidinyl][4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl]methanone; {4-[Hydroxy(diphenyl)methyl]-2H-1,2,3-triazol-2-yl}[4-(2-methyl-2-propanyl)-1-piperidinyl]methanone; (4-(tert-butyl)piperidin-1-yl)(4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl)methanone. Grades: >98%. CAS No. 2205032-89-7. Molecular formula: C25H30N4O2. Mole weight: 418.53. | |
| ML213 | ML213 is a selective activator of Kv7.2 and Kv7.4 channels, enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 489402-47-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101843. | |
| ML213 | ML213 is a selective activator of KCNQ2 (Kv7.2) and KCNQ4 (Kv7.4) with > 80-fold selectivity against other related K+ channels, and enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510 nM, respectively. Synonyms: N-(2, 4, 6-trimethylphenyl)bicyclo[2. 2. 1]heptane-3-carboxamide; N-mesitylbicyclo[2.2.1]heptane-2-carboxamide; ML213; ML 213; ML-213; CID-3111211; CID 3111211; CID3111211; AK174864; N-(2,4,6-Trimethylphenyl)-bicyclo[2.2.1]heptane-2-carboxamide. CAS No. 489402-47-3. Molecular formula: C17H23NO. Mole weight: 257.37. | |
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