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| Product | Description | |
|---|---|---|
| ML 297 | ML 297 is a Kir3.1/3.2 (GIRK1/2) channel activator with IC50 values of 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3. Synonyms: ML297; ML 297; ML-297; N-(3,4-Difluorophenyl)-N'-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea. Grades: ≥99% by HPLC. CAS No. 1443246-62-5. Molecular formula: C17H14F2N4O. Mole weight: 328.32. |  |
| ML 297 | ML 297 (VU 0456810) is a potent and selective GIRK 1/2 activator, with an EC 50 of 0.16 μM. ML 297 is potential for the treatment of epilepsy [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VU 0456810; CID 56642816. CAS No. 1443246-62-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110192. |  |
| ML-298 | ML-298 is a potent inhibitor of phospholipase D2 (PLD2) displaying selectivity for PLD2 over PLD1 with IC50 values of 355 and 20000 nM, respectively. Synonyms: ML 298; ML298; 3,4-Difluoro-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]benzamide. Grades: ≥98%. CAS No. 1426916-02-0. Molecular formula: C22H23F3N4O2. Mole weight: 432.4. | |
| ML 298 hydrochloride | ML 298 hydrochloride is a phospholipase D2 inhibitor with IC50 values are 355 for PLD2 and >20,000 nM for PLD1. It can decrease invasive migration in U87-MG glioblastoma cells. Synonyms: ML 298 hydrochloride; ML298 hydrochloride; ML-298 hydrochloride; 3,4-Difluoro-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]benzamide hydrochloride. Grades: ≥98% by HPLC. Molecular formula: C22H23F3N4O2.HCl. Mole weight: 468.9. | |
| ML 298 hydrochloride | ML 298 hydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| ML-299 | ML-299 is an allosteric, dual inhibitor of PLD1/PLD2 with IC50 values of 6 and 20 nM, respectively. It can be used as a probe for detecting PLD1 and PLD2 function in vitro and in vivo. Synonyms: ML 299; ML299; CID 56593087; 4-Bromo-N-[(2S)-1-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]propan-2-yl]benzamide. Grades: ≥95%. CAS No. 1426916-00-8. Molecular formula: C23H26BrFN4O2. Mole weight: 489.4. | |
| ML309 | ML309 is a potent inhibitor of R132H mutant IDH1 capable of reducing 2-hydroxyglutarate production in U87 MG glioblastoma cells. ML309 is capable of potent and selective inhibition of mutant IDH1 and effectively lowers cell-based production of 2-HG in a U87MG mutant glioblastoma cell line. Synonyms: ML-309; ML 309. Grades: 98%. CAS No. 1355446-05-7. Molecular formula: C29H29FN4O2. Mole weight: 484.56. | |
| ML-309 hydrochloride | ML-309 is a potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (IDH1). It reduces 2-hydroxyglutarate production in U87 MG glioblastoma cells. Synonyms: ML 309 hydrochloride; ML309 hydrochloride; ML-309 HCl; 2-(N-[2-(benzimidazol-1-yl)acetyl]-3-fluoroanilino)-N-cyclopentyl-2-(2-methylphenyl)acetamide hydrochloride. Grades: ≥98%. CAS No. 1355327-02-4. Molecular formula: C29H29FN4O2·HCl. Mole weight: 521. | |
| ML311 | ML311, also known as EU-5346, is a potent and selective inhibitor of the Protein-Protein Interaction of Mcl-1 and Bim. EU-5346 inhibits proliferation of Her2-positive BC cells in a dose-dependent manner. ML311 is a useful tool for studying lymphoid tumorigenesis and to demonstrate the potential for using this strategy in therapies intended to bypass apoptosis resistance pathways that are activated in drug-resistant tumors. Synonyms: 7-[ (4-Ethylpiperazin-1-yl) -[4- (trifluoromethyl) phenyl]methyl]quinolin-8-ol; ML311; ML-311; ML 311; EU-5346; EU 5346; EU5346. CAS No. 315698-17-0. Molecular formula: C23H24F3N3O. Mole weight: 415.46. | |
| ML-314 | Medicinal chemistry optimization of MLS-0233108 led to ML314, the most potent molecule in this second series that exhibited full agonist behavior (100 %) on NTR1 (EC50 = 1.9 μM). ML314 showed good selectivity against NTR2 and GPR35, but did not stimulate Ca2+ mobilization. ML314 is potentially a biased agonist operating via the β-arrestin pathway rather than the traditional Gq coupled pathway. Signaling mediated by β-arrestin has distinct biochemical and functional consequences that may lead to physiological advantages as described below. This probe report describes the discovery and properties of ML301 and summarizes the HTS and follow-up campaign, which identified ML314. Synonyms: ML 314; ML-314; ML314. Grades: 0.98. CAS No. 1448895-09-7. Molecular formula: C24H28N4O3. Mole weight: 420.513. | |
| ML 315 hydrochloride | ML 315 hydrochloride is a cdc2-like kinase and DYRK kinase inhibitor with IC50 values of 68, 68 and 231 nM for Clk1, Clk4 and Clk2 and 282 and 1156 nM for Dyrk1A and Dyrk1B. Synonyms: ML 315 hydrochloride; ML315 hydrochloride; ML-315 hydrochloride; 5-(1,3-Benzodioxol-5-yl)-N-[(3,5-dichlorophenyl)methyl]-4-pyrimidinamine hydrochloride. Grades: ≥98% by HPLC. CAS No. 1440251-53-5. Molecular formula: C18H13Cl2N3O2.HCl. Mole weight: 410.68. | |
| ML 315 hydrochloride | ML 315 is a selective dual inhibitor of CDK and DYRK with IC 50 s of 68 nM and 282 nM, respectively. ML 315 is used in cancer and neurological disease research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2172559-91-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-117608A. | |
| ML318 | ML318 is a novel inhibitor of Pseudomonas aeruginosa PvdQ acylase, an enzyme involved in siderophore pyoverdine synthesis. Group: Biochemicals. Grades: Highly Purified. CAS No. 1610516-67-0. Pack Sizes: 1mg, 5mg. Molecular Formula: C14H8F4N2, Molecular Weight: 280.22. US Biological Life Sciences. | Worldwide |
| ML-323 | ML323 is a reversible and potent USP1-UAF1 inhibitor with IC50 vallue of 76 nM in a Ub-Rho assay and 174 nM and 820 nM in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) and monoubiquitinated PCNA (Ub-PCNA) as substrates, respectively. Synonyms: ML-323; ML 323; ML323. CAS No. 1572414-83-5. Molecular formula: C23H24N6. Mole weight: 384.487. | |
| ML324 | ML324 exhibits good Caco-2 cell permeability, and possesses excellent microsomal stability in the presence of both mouse and rat liver microsomes. Synonyms: ML-324; ML 324; ML324; CID-44143209; CID 44143209; CID44143209. Grades: >98%. CAS No. 1222800-79-4. Molecular formula: C21H23N3O2. Mole weight: 349.43. | |
| ML 324 dihydrochloride | ML 324 dihydrochloride is an inhibitor of Jumonji domain-containing protein 2 (JMJD2) histone demethylase. It potently suppresses herpes simplex virus (HSV) IE gene expression and viral reactivation from latency. Synonyms: ML 324 dihydrochloride; ML324 dihydrochloride; ML-324 dihydrochloride; N-[3-(dimethylamino)propyl]-4-(8-hydroxy-6-quinolinyl)-benzamide dihydrochloride. Grades: 99%. Molecular formula: C21H23N3O2.2HCl. Mole weight: 422.35. | |
| ML329 | ML329 is a small molecule MITF inhibitor that inhibits the expression of numerous micropthalmia-associated transcription factor (MITF) target genes and blocks the proliferation of numerous cell lines that require MITF for proliferation. ML329 inhibits TRPM-1 promoter activity (IC50 = 1.2 μM). Synonyms: 4-[(1,4-dioxonaphthalen-2-yl)amino]benzenesulfonamide; ML329; ML 329; ML-329. CAS No. 19992-50-8. Molecular formula: C16H12N2O4S. Mole weight: 328.34. | |
| ML 334 | ML 334 is an inhibitor of Keap1-Nrf2 interaction. It can affect the cytoprotective responses to oxidative and electrophilic stress. Synonyms: ML 334; ML334; ML-334; (1S, 2R) -2- [ [ (1S) -1- [ (1, 3-Dihydro-1, 3-dioxo-2H-isoindol-2-yl) methyl] -3, 4-dihydro-2 (1H) -isoquinolinyl] carbonyl] cyclohexanecarboxylic acid. Grades: ≥98% by HPLC. CAS No. 1432500-66-7. Molecular formula: C26H26N2O5. Mole weight: 446.5. | |
| ML-335 | ML-335 is a potent and selective TREK-1/2 activator with EC50 values of 14.3 μM and 5.2 μM, respectively. Synonyms: ML 335; ML335; N-[(2,4-Dichlorophenyl)methyl]-4-[(methylsulfonyl)amino]benzamide. Grades: ≥98% by HPLC. CAS No. 825658-06-8. Molecular formula: C15H14Cl2N2O3S. Mole weight: 373.25. | |
| ML-336 | ML-336 is a quinazolinone-based inhibitor of Venezuelan Equine Encephalitis Virus (VEEV). It inhibits VEEV-induced cytopathic effect in three strains of the virus (TC-83, V3526, and Trinidad donkey). Synonyms: ML 336; ML336; (E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-n-phenylbenzamide. Grades: ≥95%. CAS No. 1613465-33-0. Molecular formula: C19H21N5O3. Mole weight: 367.4. | |
| ML337 | ML337 is a Selective negative allosteric modulator of mGlu3 with IC50 value of 593 nM. It shows no activity at mGlu1, mGlu2 or mGlu4-8 at concentrations up to 30 μM. ML337 is a best-in-class probe for studying non-competitive antagonism of mGlu3. Uses: In vitro and in vivo probe for studying non-competitive antagonism of mglu3. Synonyms: CHEMBL2385886; ML337; ML 337; ML-337; MLS004580699; GTPL8765;(R)-(2-fluoro-4-((4-methoxyphenyl)ethynyl)phenyl)(3-hydroxypiperidin-1-yl)methanone. Grades: 98%. CAS No. 1443118-44-2. Molecular formula: C21H20FNO3. Mole weight: 353.39. | |
| ML 337 | ML 337. Group: Biochemicals. Grades: Purified. CAS No. 1443118-44-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML339 | ML339 is a potent and selective CXCR6 antagonist (IC50 = 140 nM) that is selective (IC50 >79 μM) against CXCR5, CXCR4, CCR6 and Apelin receptor (APJ). It has the potential to advance the field of prostate cancer research. Synonyms: N-[(1R,5S)-9-{2-[(2-Chlorophenyl)amino]-2-oxoethyl}-9-azabicyclo[3.3.1]non-3-yl]-3,4,5-trimethoxybenzamide; 9-Azabicyclo[3.3.1]nonane-9-acetamide, N-(2-chlorophenyl)-3-[(3,4,5-trimethoxybenzoyl)amino]-, (3-exo)-. Grades: ≥95%. CAS No. 2579689-83-9. Molecular formula: C26H32ClN3O5. Mole weight: 502.00. | |
| ML-339 | ML-339 is a potent and selective hCXCR6 antagonist (IC50 = 140 nM). Uses: Designed for use in research and industrial production. Additional or Alternative Names: ML-339; ML 339; ML339. Product Category: Antagonists. Appearance: Solid powder. CAS No. 2579689-83-9. Molecular formula: C26H32ClN3O5. Mole weight: 502.01. Purity: >98%. IUPACName: N-((1R,3s,5S)-9-(2-((2-chlorophenyl)amino)-2-oxoethyl)-9-azabicyclo[3.3.1]nonan-3-yl)-3,4,5-trimethoxybenzamide. Canonical SMILES: O=C(N[C@@H]1C[C@H](N2CC(NC3=CC=CC=C3Cl)=O)CCC[C@H]2C1)C4=CC(OC)=C(OC)C(OC)=C4. Product ID: ACM2579689839. Alfa Chemistry ISO 9001:2015 Certified. Categories: MD 339. |  |
| ML3403 | ML 3403 is a potent and selective p38 mitogen-activated protein kinase (MAPK) inhibitor. MAPK is a key mediator in cytokine-induced signaling events and plays an integral role in disease states including oncogenesis, autoimmune diseases, and inflammatory processes. Therefore, MAPK inhibitors such as ML 3403 provides an attractive strategy for therapeutic intervention. Synonyms: ML 3403; ML-3403; p38 MAP Kinase Inhibitor III; 4-(4-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-5-yl)-N-(1-phenylethyl)pyridin-2-amine. Grades: 98%. CAS No. 549505-65-9. Molecular formula: C23H21FN4S. Mole weight: 404.51. | |
| ML 3403 | ML 3403. Group: Biochemicals. Grades: Purified. CAS No. 549505-65-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML-345 | ML-345 is a small-molecule inhibitor of insulin-degrading enzyme (IDE) that selectively targets Cys819 in IDE. ML-345 is potentially utilized as a pharmacophore for drug development in diabetes and Alzheimer's disease research. Synonyms: ML 345; ML345; 5-Fluoro-2-(2-morpholin-4-yl-5-morpholin-4-ylsulfonylphenyl)-1,2-benzothiazol-3-one. Grades: ≥95%. CAS No. 1632125-79-1. Molecular formula: C21H22FN3O5S2. Mole weight: 479.5. | |
| ML346 | ML346, a barbituric acid skeleton compound, is a novel activator of Hsp70 which could induce HSF-1-dependent chaperone expression and repair protein folding in both cellular and animal models. It has no obvious cytotoxicity and shows some extent of specif. Uses: Ml346 is a novel activator of hsp70 which could induce hsf-1-dependent chaperone expression and repair protein folding in both cellular and animal models. Synonyms: ML346; ML-346; ML 346; ZINC00244844; AC1LG9A8; Ambcb5772104; MLS004711999; SCHEMBL13317556. Grades: 95%. CAS No. 100872-83-1. Molecular formula: C14H12N2O4. Mole weight: 272.26. | |
| ML347 | ML347 is a selective BMP receptor inhibitor with IC50 value of 32 nM for ALK2, >300-fold selectivity over ALK3. It also inhibits ALK1 activity with IC50 value of 46 nM. Synonyms: ML-347; 5-[6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline. Grades: >98%. CAS No. 1062368-49-3. Molecular formula: C22H16N4O. Mole weight: 352.39. | |
| ML 347 | ML 347. Group: Biochemicals. Grades: Purified. CAS No. 1062368-49-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML348 | ML348, also known as CID 3238952 or SID 160654487, is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM). It is 14-fold selective for LYPLA1 over LYPLA2 (IC50 = >3,000) and demonstrates little activity against a panel of more than 20 other serine hydrolases (IC50s = >10,000). Synonyms: N-[2-chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-1-piperazineacetamide; ML348; ML-348; ML 348; CID 3238952; SID 160654487. CAS No. 899713-86-1. Molecular formula: C18H17ClF3N3O3. Mole weight: 415.79. | |
| ML 348 | ML 348. Group: Biochemicals. Grades: Purified. CAS No. 899713-86-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 349 | ML 349 is a lysophospholipase 2 inhibitor with IC50 value of 144 nM. Synonyms: ML349; ML-349; ML 349. (5,5-Dioxido-4H-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]methanone. Grades: ≥98% by HPLC. CAS No. 890819-86-0. Molecular formula: C23H22N2O4S2. Mole weight: 454.56. | |
| ML 349 | ML 349. Group: Biochemicals. Grades: Purified. CAS No. 890819-86-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML351 | ML351 is a potent and highly specific 15-LOX-1 inhibitor with an IC 50 of 200 nM. ML351 shows excellent selectivity (>250-fold) versus the related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2 [1]. ML351 prevents dysglycemia and reduces β-cell oxidative stress in nonobese diabetic mouse model of T1D [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 847163-28-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111310. | |
| ML 351 | ML 351 is a potent and selective inhibitor of 12/15-lipoxygenase (IC50 value 200 nM against human 12/15-LOX), which catalyzes the oxidation of polyunsaturated fatty acids to produce unsaturated fatty acid hydroperoxides. Studies indicate that ML351 is protective against oxidative glutamate toxicity in mouse neuronal HT22 cells, and reduces infarct size following permanent focal ischemia in a mouse model of ischemic stroke. Synonyms: ML 351; ML-351; ML351; CID 664510; CID664510; CID-664510; 5-(methylamino)-2-naphthalen-1-yl-1,3-oxazole-4-carbonitrile. Grades: 98%. CAS No. 847163-28-4. Molecular formula: C15H11N3O. Mole weight: 249.27. | |
| ML352 | ML352 is a potent and non-competitive inhibitor of the presynaptic choline transporter (CHT; Ki value 92 nM). Synonyms: ML352; ML-352; ML 352; VU0476201; VU-0476201; VU 0476201; VU0476328; VU-0476328; VU 0476328; N-((3-Isopropylisoxazol-5-yl)methyl)-4-methoxy-3-((1-methylpiperidin-4-yl)oxy)benzamide; 4-methoxy-3-(1-methylpiperidin-4-yl)oxy-N-[(3-propan-2-yl-1,2-oxazol-5-yl)methyl]benzamide. Grades: 98%. CAS No. 1649450-12-3. Molecular formula: C21H29N3O4. Mole weight: 387.47. | |
| ML 352 hydrochloride | ML 352 hydrochloride is a selective presynaptic choline transporter inhibitor. Synonyms: ML 352 hydrochloride; ML352 hydrochloride; ML-352 hydrochloride; 4-Methoxy-N-[[3-(1-methylethyl)-5-isoxazolyl]methyl]-3-[(1-methyl-4-piperidinyl)oxy]benzamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 1962928-20-6. Molecular formula: C21H29N3O4.HCl. Mole weight: 423.93. | |
| ML 354 | ML 354. Group: Biochemicals. Grades: Purified. CAS No. 89159-60-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 354 | ML 354 is a selective PAR4 antagonist with IC50 value of 140 nM. Synonyms: ML354; ML-354; ML 354; VU0099704; VU-0099704; VU 0099704; 1-Methyl-5-nitro-3-phenyl-1H-indole-2-methanol. Grades: ≥98% by HPLC. CAS No. 89159-60-4. Molecular formula: C16H14N2O3. Mole weight: 282.29. | |
| ML355 | ML355 inhibits PAR-4 induced aggregation and calcium mobilization in human platelets and reduce 12-HETE in β-cells. Synonyms: ML 355; ML-355. Grades: >98%. CAS No. 1532593-30-8. Molecular formula: C21H19N3O4S2. Mole weight: 441.52. | |
| ML-356 | ML-356 is a potent and selective inhibitor of the thioesterase domain of fatty acid synthase (FASN-TE). It blocks the biosynthesis of palmitate, the end product of FASN. Synonyms: ML 356; ML356; 2-Ethyl-N-[4-(4-morpholin-4-ylsulfonylphenyl)-1,3-thiazol-2-yl]butanamide. Grades: ≥98%. CAS No. 1808260-45-8. Molecular formula: C19H25N3O4S2. Mole weight: 423.5. | |
| ML364 | ML364 is a small molecule, reversible inhibitor of the deubiquitinase USP2, that has an IC50 value of 1.1 μM in a fluorescence-based assay using di-ubiquitin substrates. Consistent with the role of cyclin D1 in DNA damage response, ML364 also caused a decrease in homologous recombination-mediated DNA repair. Synonyms: 2-[(4-Methylphenyl)sulfonylamino]-N-(4-phenyl-1,3-thiazol-2-yl)-4-(trifluoromethyl)benzamide; ML364; ML 364; ML-364. CAS No. 1991986-30-1. Molecular formula: C24H18F3N3O3S2. Mole weight: 517.54. | |
| ML-365 | ML-365 is a potent and novel selective small molecule inhibitor of TASK1 with IC50 of 4 nM(thallium influx fluorescent assay) and 16 nM(automated electrophysiology assay). It possesses more than 60-fold selectivity for inhibition of TASK1 over TASK3. It displays little or no inhibition at 30 μM of more distantly related Kir2.1, voltage-gated potassium channel, KQT-like subfamily, member 2 (KCNQ2) and human ether-a go-go-related gene (hERG). It is a useful pharmacological probe for in vitro studies of TASK1 function. It mainly aimed at developing therapeutic intervention in further studies. Uses: Ml365 is a useful pharmacological probe for in vitro studies of task1 function. it mainly aimed at developing therapeutic intervention in further studies. Synonyms: 2-Methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide; ML365; ML-365; ML 365. Grades: >98 %. CAS No. 947914-18-3. Molecular formula: C22H20N2O3. Mole weight: 360.41. | |
| ML367 | ML367 is an effective inhibitor for the stabilization of micromolar ATPase family AAA domain containing protein 5 (ATAD5), and can be used as a probe molecule with low micromolar inhibitory activity. Synonyms: NCGC00262816-01; CBMicro_009721; ChemDiv1_005670; Oprea1_377205; MLS000591778. Grades: 98%. CAS No. 381168-77-0. Molecular formula: C19H12F2N4. Mole weight: 334.3. | |
| ML 382 | ML 382 is an allosteric modulator of MrgX1 with EC50 value of 190 nM. Synonyms: ML382; ML-382; ML 382; 2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide. Grades: ≥98% by HPLC. CAS No. 1646499-97-9. Molecular formula: C18H20N2O4S. Mole weight: 360.43. | |
| ML385 | ML385 Inhibitor. Uses: Scientific use. Product Category: T4360. CAS No. 846557-71-9. |  |
| ML 385 | ML 385 is a novel and specific inhibitor of nuclear factor erythroid 2-related factor 2 (Nrf2; IC50 = 1.9 μM). ML 385 blocks NRF2 transcriptional activity, and enhances the efficacy of carboplatin as well as other chemotherapeutic drugs in lung cancer cells (NSCLC). Synonyms: ML-385; ML 385; ML385; 2-(1,3-benzodioxol-5-yl)-N-[5-methyl-4-[1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl]-1,3-thiazol-2-yl]acetamide. CAS No. 846557-71-9. Molecular formula: C29H25N3O4S. Mole weight: 511.596. | |
| ML390 | ML-390 is an inhibitor of human DHODH, which induces differentiation in acute myeloid leukemia cell lines U937 (murine) and THP-1 (human) cell lines with an EC50 value of approximately 2 μM. Synonyms: ML390; ML 390; ML-390. Grades: 99%. CAS No. 2029049-79-2. Molecular formula: C21H21F3N2O3. Mole weight: 406.4. | |
| ML398 hydrochloride | ML398 is potent dopamine 4 receptor antagonist with IC50 value of 130 nM and Ki of 36 nM. It exhibits no activity against the other dopamine receptors tested (>20 μM against D1, D2S, D2L, D3, and D5) ML398 shows >100-fold selectivity for the other dopamine receptors. Synonyms: ML398 hydrochloride; ML 398 hydrochloride; ML-398 hydrochloride; (R)-4-((1H-benzo[d]imidazol-2-yl)methyl)-2-phenethylmorpholine hydrochloride. Grades: 98%. CAS No. 1379510-21-0. Molecular formula: C20H24ClN3O. Mole weight: 357.88. | |
| ML401 | ML401 is a selective EBI2 (GPR183) receptor antagonist (IC50 of 1.03 nM). Grades: 98%. CAS No. 1597489-14-9. Molecular formula: C20H20BrClN2O. Mole weight: 419.7. | |
| ML 67-33 | ML 67-33 is a K2P potassium channel activator that increases channel currents by activating core gating apparatus of channels. Synonyms: 2,7-Dichloro-9,10-dihydro-9,9-dimethyl-10-[2-(2H-tetrazol-5-yl)ethyl]acridine. Grades: 97%. CAS No. 1443290-89-8. Molecular formula: C18H17Cl2N5. Mole weight: 374.27. | |
| ML-7 | ML-7 is a potent and selective inhibitor of myosin light chain(MLC) kinase with Ki value of 0.3 μM. It has been shown to protect cardiac function from ischemia/reperfusion (I/R) injury. It inhibts smooth-muscle myosin light chain kinase, protein kinase C (PKC) and cAMP-dependent protein kinase (PKA). Uses: Ml-7 hydrochloride has been shown to protect cardiac function from ischemia/reperfusion (i/r) injury. Synonyms: ML7; ML 7; 1-[(5-iodo-1-naphthyl)sulfonyl]-1,4-diazepane. Grades: >98%. CAS No. 109376-83-2. Molecular formula: C15H17IN2O2S. Mole weight: 416.28. | |
| ML 786 dihydrochloride | ML786 dihydrochloride is a Raf kinase inhibitor with IC50 values are 2.1, 2.5 and 4.2 nM for B-RafV600E, C-Raf and wild-type B-Raf respectively. It may be used in novel cancer therapies in the future. Synonyms: MLN786 Dihydrochloride; MLN-786 Dihydrochloride; MLN 786 Dihydrochloride; MLN786 2HCl; MLN-786 2HCl; MLN 786 2HCl; 3-(1-Amino-1-methylethyl)-N-[(2R)-1,2,3,4-tetrahydro-7-oxo-1,8-naphthryridin-4-yl)oxy]-2-naphthalenyl]-5-benzamide dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1237536-18-3. Molecular formula: C29H29F3N4O3.2HCl. Mole weight: 611.48. | |
| ML 786 dihydrochloride | ML 786 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1237536-18-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| ML 7 hydrochloride | ML 7 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 110448-33-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML-7 hydrochloride | ML-7 hydrochloride is a naphthalene sulphonamide derivative, potently inhibits MLCK ( IC 50 =300 nM). ML-7 hydrochloride also inhibits YAP/TAZ. Uses: Scientific research. Group: Signaling pathways. CAS No. 110448-33-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15417. | |
| ML-7 hydrochloride | ML-7 Hcl is a cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM). It also inhibt smooth-muscle myosin light chain kinase, protein kinase C (PKC) and cAMP-dependent protein kinase (PKA). Synonyms: ML-7 HCl; ML-7 hydrochloride; ML-7; ML 7; ML7. Grades: >98%. CAS No. 110448-33-4. Molecular formula: C15H18ClIN2O2S. Mole weight: 452.74. | |
| ML-9 | ML-9 is a myosin light chain kinase (MLCK) inhibitor. It enhances the anticancer activity of docetaxel and has potential application as an adjuvant to existing anticancer chemotherapy. It is used as an attractive tool for targeting autophagy in cancer therapy through dual inhibition of both the Akt pathway and the autophagy. Uses: Ml-9 has potential application as an adjuvant to existing anticancer chemotherapy. Synonyms: ML9; ML 9; 1H-1,4-Diazepine, 1-[(5-chloro-1-naphthalenyl)sulfonyl]hexahydro-. Grades: >98%. CAS No. 110448-31-2. Molecular formula: C15H17ClN2O2S. Mole weight: 324.82. | |
| ML-9 | ML-9 is a selective and potent inhibitor of Akt kinase , inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity [3]. ML-9 inhibits inhibits MLCK, PKA and PKC activity with K i values of 4, 32 and 54 μM, respectively [1]. ML-9 induces autophagy by stimulating autophagosome formation and inhibiting their degradation [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 105637-50-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-100932. | |
| ML 9 hydrochloride | ML 9 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 105637-50-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML-9 hydrochloride | ML-9 hydrochloride is a myosin light chain kinase (MLCK) inhibitor. It enhances the anticancer activity of docetaxel and may be used as an adjuvant to existing anticancer chemotherapy. It inhibits natural killer (NK) cell activity in a dose-dependent manner without affecting target cell binding. It inhibits insulin-induced translocation of both GLUT4 and GLUT1 in a dose-dependent manner. It also inhibits agonist-induced Ca2+ entry into endothelial cells and catecholamine secretion in intact and permeabilized chromaffin cells. It inhibits the catalytic activities of several protein kinases competitively with respect to ATP and exhibited different Ki values toward each protein kinase. It may be a new type of vascular relaxant. Uses: Ml-9 hydrochloride may be used as an adjuvant to existing anticancer chemotherapy. it may be a new type of vascular relaxant. Synonyms: ML9; ML-9; ML 9; ML9 Hydrochloride;ML 9 Hydrochloride; 1-(5-Chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine HCl;1-(5-Chloronaphthalen-1-yl)sulfonyl-1,4-diazepane hydrochloride. Grades: 95%. CAS No. 105637-50-1. Molecular formula: C15H18Cl2N2O2S. Mole weight: 361.29. | |
| MLCK inhibitor peptide | MLCK inhibitor peptide. Group: Biochemicals. Grades: Purified. CAS No. 198694-74-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Mlck inhibitor peptide 18 | MLCK inhibitor peptide 18 is a myosin light chain kinase (MLCK) inhibitor with an IC50 of 50 nM, and inhibits CaM kinase II only at 4000-fold higher concentrations. Uses: Designed for use in research and industrial production. Additional or Alternative Names: H-RKKYKYRRK-NH2;MYOSIN LIGHT CHAIN KINASE INHIBITOR PEPTIDE 18;MLCK INHIBITOR PEPTIDE 18. Product Category: Inhibitors. CAS No. 224579-74-2. Molecular formula: C60H105N23O11. Mole weight: 1324.62. Purity: 0.9966. Product ID: ACM224579742. Alfa Chemistry ISO 9001:2015 Certified. | |
| MLCK inhibitor peptide 18 | MLCK inhibitor peptide 18. Group: Biochemicals. Grades: Purified. CAS No. 224579-74-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| MLCK inhibitor peptide 18 | A myosin light chain kinase (MLCK) inhibitor (IC50= 50 nM), and inhibits CaM kinase IIonly at 4000-fold higher concentrations. Synonyms: Myosin Light Chain Kinase Inhibitor Peptide 18. Grades: ≥95%. CAS No. 224579-74-2. Molecular formula: C60H105N23O11. Mole weight: 1324.64. | |
| MLCK inhibitor peptide 18 | MLCK inhibitor peptide 18 is a myosin light chain kinase ( MLCK ) inhibitor with an IC 50 of 50 nM, and inhibits CaM kinase II only at 4000-fold higher concentrations. Uses: Scientific research. Group: Peptides. CAS No. 224579-74-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P1029. | |
| MLCK inhibitor peptide 18 acetate | MLCK inhibitor peptide 18 acetate is a selective competitive myosin light chain kinase (MLCK) inhibitor (IC50 = 50 nM) that inhibits CaM kinase II only at 4000-fold higher concentrations. Synonyms: H-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH2.CH3CO2H; L-arginyl-L-lysyl-L-lysyl-L-tyrosyl-L-lysyl-L-tyrosyl-L-arginyl-L-arginyl-L-lysinamide acetate. Grades: ≥95%. Molecular formula: C62H109N23O13. Mole weight: 1384.67. | |
| MLH3 protein, partial (135-151) | MLH3 protein, partial (135-151) is a 7-aa peptide. MLH3 is a DNA mismatch repair gene associated with mammalian microsatellite instability. | |
| MLi-2 | MLi-2 is a potent, orally available and brain penetrant inhibitor of LRRK2 (IC50 = 0.76 nM) with excellent selectivity that shows >295-fold selectivity for over 300 kinases and a diverse panel of receptors and ion channels. Synonyms: (2R,6S)-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1H-indazol-3-yl]pyrimidin-4-yl]morpholine; MLi-2; MLi 2; MLi2. CAS No. 1627091-47-7. Molecular formula: C21H25N5O2. Mole weight: 379.46. | |
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