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| Product | Description | |
|---|---|---|
| ML352 | ML352 is a potent and non-competitive inhibitor of the presynaptic choline transporter (CHT; Ki value 92 nM). Synonyms: ML352; ML-352; ML 352; VU0476201; VU-0476201; VU 0476201; VU0476328; VU-0476328; VU 0476328; N-((3-Isopropylisoxazol-5-yl)methyl)-4-methoxy-3-((1-methylpiperidin-4-yl)oxy)benzamide; 4-methoxy-3-(1-methylpiperidin-4-yl)oxy-N-[(3-propan-2-yl-1,2-oxazol-5-yl)methyl]benzamide. Grades: 98%. CAS No. 1649450-12-3. Molecular formula: C21H29N3O4. Mole weight: 387.47. |  |
| ML 352 hydrochloride | ML 352 hydrochloride is a selective presynaptic choline transporter inhibitor. Synonyms: ML 352 hydrochloride; ML352 hydrochloride; ML-352 hydrochloride; 4-Methoxy-N-[[3-(1-methylethyl)-5-isoxazolyl]methyl]-3-[(1-methyl-4-piperidinyl)oxy]benzamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 1962928-20-6. Molecular formula: C21H29N3O4.HCl. Mole weight: 423.93. | |
| ML 354 | ML 354. Group: Biochemicals. Grades: Purified. CAS No. 89159-60-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| ML 354 | ML 354 is a selective PAR4 antagonist with IC50 value of 140 nM. Synonyms: ML354; ML-354; ML 354; VU0099704; VU-0099704; VU 0099704; 1-Methyl-5-nitro-3-phenyl-1H-indole-2-methanol. Grades: ≥98% by HPLC. CAS No. 89159-60-4. Molecular formula: C16H14N2O3. Mole weight: 282.29. | |
| ML355 | ML355 inhibits PAR-4 induced aggregation and calcium mobilization in human platelets and reduce 12-HETE in β-cells. Synonyms: ML 355; ML-355. Grades: >98%. CAS No. 1532593-30-8. Molecular formula: C21H19N3O4S2. Mole weight: 441.52. | |
| ML-356 | ML-356 is a potent and selective inhibitor of the thioesterase domain of fatty acid synthase (FASN-TE). It blocks the biosynthesis of palmitate, the end product of FASN. Synonyms: ML 356; ML356; 2-Ethyl-N-[4-(4-morpholin-4-ylsulfonylphenyl)-1,3-thiazol-2-yl]butanamide. Grades: ≥98%. CAS No. 1808260-45-8. Molecular formula: C19H25N3O4S2. Mole weight: 423.5. | |
| ML364 | ML364 is a small molecule, reversible inhibitor of the deubiquitinase USP2, that has an IC50 value of 1.1 μM in a fluorescence-based assay using di-ubiquitin substrates. Consistent with the role of cyclin D1 in DNA damage response, ML364 also caused a decrease in homologous recombination-mediated DNA repair. Synonyms: 2-[(4-Methylphenyl)sulfonylamino]-N-(4-phenyl-1,3-thiazol-2-yl)-4-(trifluoromethyl)benzamide; ML364; ML 364; ML-364. CAS No. 1991986-30-1. Molecular formula: C24H18F3N3O3S2. Mole weight: 517.54. | |
| ML-365 | ML-365 is a potent and novel selective small molecule inhibitor of TASK1 with IC50 of 4 nM(thallium influx fluorescent assay) and 16 nM(automated electrophysiology assay). It possesses more than 60-fold selectivity for inhibition of TASK1 over TASK3. It displays little or no inhibition at 30 μM of more distantly related Kir2.1, voltage-gated potassium channel, KQT-like subfamily, member 2 (KCNQ2) and human ether-a go-go-related gene (hERG). It is a useful pharmacological probe for in vitro studies of TASK1 function. It mainly aimed at developing therapeutic intervention in further studies. Uses: Ml365 is a useful pharmacological probe for in vitro studies of task1 function. it mainly aimed at developing therapeutic intervention in further studies. Synonyms: 2-Methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide; ML365; ML-365; ML 365. Grades: >98 %. CAS No. 947914-18-3. Molecular formula: C22H20N2O3. Mole weight: 360.41. | |
| ML367 | ML367 is an effective inhibitor for the stabilization of micromolar ATPase family AAA domain containing protein 5 (ATAD5), and can be used as a probe molecule with low micromolar inhibitory activity. Synonyms: NCGC00262816-01; CBMicro_009721; ChemDiv1_005670; Oprea1_377205; MLS000591778. Grades: 98%. CAS No. 381168-77-0. Molecular formula: C19H12F2N4. Mole weight: 334.3. | |
| ML 382 | ML 382 is an allosteric modulator of MrgX1 with EC50 value of 190 nM. Synonyms: ML382; ML-382; ML 382; 2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide. Grades: ≥98% by HPLC. CAS No. 1646499-97-9. Molecular formula: C18H20N2O4S. Mole weight: 360.43. | |
| ML385 | ML385 Inhibitor. Uses: Scientific use. Product Category: T4360. CAS No. 846557-71-9. |  |
| ML 385 | ML 385 is a novel and specific inhibitor of nuclear factor erythroid 2-related factor 2 (Nrf2; IC50 = 1.9 μM). ML 385 blocks NRF2 transcriptional activity, and enhances the efficacy of carboplatin as well as other chemotherapeutic drugs in lung cancer cells (NSCLC). Synonyms: ML-385; ML 385; ML385; 2-(1,3-benzodioxol-5-yl)-N-[5-methyl-4-[1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl]-1,3-thiazol-2-yl]acetamide. CAS No. 846557-71-9. Molecular formula: C29H25N3O4S. Mole weight: 511.596. | |
| ML390 | ML-390 is an inhibitor of human DHODH, which induces differentiation in acute myeloid leukemia cell lines U937 (murine) and THP-1 (human) cell lines with an EC50 value of approximately 2 μM. Synonyms: ML390; ML 390; ML-390. Grades: 99%. CAS No. 2029049-79-2. Molecular formula: C21H21F3N2O3. Mole weight: 406.4. | |
| ML398 hydrochloride | ML398 is potent dopamine 4 receptor antagonist with IC50 value of 130 nM and Ki of 36 nM. It exhibits no activity against the other dopamine receptors tested (>20 μM against D1, D2S, D2L, D3, and D5) ML398 shows >100-fold selectivity for the other dopamine receptors. Synonyms: ML398 hydrochloride; ML 398 hydrochloride; ML-398 hydrochloride; (R)-4-((1H-benzo[d]imidazol-2-yl)methyl)-2-phenethylmorpholine hydrochloride. Grades: 98%. CAS No. 1379510-21-0. Molecular formula: C20H24ClN3O. Mole weight: 357.88. | |
| ML-3H2 | Heterocyclic Organic Compound. Alternative Names: 5-chloro-7-(diethylaminomethyl)quinolin-8-ol, F0870-0084, 5-chloro-7-((diethylamino)methyl)quinolin-8-ol, 5-chloro-7-[(diethylamino)methyl]quinolin-8-ol, IFLab1_003997, AC1LER08, Oprea1_348250, SureCN11955299, ML-3H2, MolPort-000-422-528, HMS1423F15, STL228085, AKOS000808440, MCULE-5516213537, EU-0009298, ST45175606, 5-Chloro-7-[(diethylamino)methyl]-8-quinolinol, 7-[(diethylamino)methyl]-5-chloroquinolin-8-ol, 103325-93-5. CAS No. 103325-93-5. Molecular formula: C14H17ClN2O. Mole weight: 264.75. Purity: 0.96. IUPACName: 5-chloro-7-(diethylaminomethyl)quinolin-8-ol. Canonical SMILES: CCN(CC)CC1=CC(=C2C=CC=NC2=C1O)Cl. Catalog: ACM103325935. |  |
| ML401 | ML401 is a selective EBI2 (GPR183) receptor antagonist (IC50 of 1.03 nM). Grades: 98%. CAS No. 1597489-14-9. Molecular formula: C20H20BrClN2O. Mole weight: 419.7. | |
| ML 67-33 | ML 67-33 is a K2P potassium channel activator that increases channel currents by activating core gating apparatus of channels. Synonyms: 2,7-Dichloro-9,10-dihydro-9,9-dimethyl-10-[2-(2H-tetrazol-5-yl)ethyl]acridine. Grades: 97%. CAS No. 1443290-89-8. Molecular formula: C18H17Cl2N5. Mole weight: 374.27. | |
| ML-7 | ML-7 is a potent and selective inhibitor of myosin light chain(MLC) kinase with Ki value of 0.3 μM. It has been shown to protect cardiac function from ischemia/reperfusion (I/R) injury. It inhibts smooth-muscle myosin light chain kinase, protein kinase C (PKC) and cAMP-dependent protein kinase (PKA). Uses: Ml-7 hydrochloride has been shown to protect cardiac function from ischemia/reperfusion (i/r) injury. Synonyms: ML7; ML 7; 1-[(5-iodo-1-naphthyl)sulfonyl]-1,4-diazepane. Grades: >98%. CAS No. 109376-83-2. Molecular formula: C15H17IN2O2S. Mole weight: 416.28. | |
| ML 786 dihydrochloride | ML 786 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1237536-18-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| ML 786 dihydrochloride | ML786 dihydrochloride is a Raf kinase inhibitor with IC50 values are 2.1, 2.5 and 4.2 nM for B-RafV600E, C-Raf and wild-type B-Raf respectively. It may be used in novel cancer therapies in the future. Synonyms: MLN786 Dihydrochloride; MLN-786 Dihydrochloride; MLN 786 Dihydrochloride; MLN786 2HCl; MLN-786 2HCl; MLN 786 2HCl; 3-(1-Amino-1-methylethyl)-N-[(2R)-1,2,3,4-tetrahydro-7-oxo-1,8-naphthryridin-4-yl)oxy]-2-naphthalenyl]-5-benzamide dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1237536-18-3. Molecular formula: C29H29F3N4O3.2HCl. Mole weight: 611.48. | |
| ML 7 hydrochloride | ML 7 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 110448-33-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML-7 hydrochloride | ML-7 hydrochloride is a naphthalene sulphonamide derivative, potently inhibits MLCK ( IC 50 =300 nM). ML-7 hydrochloride also inhibits YAP/TAZ. Uses: Scientific research. Group: Signaling pathways. CAS No. 110448-33-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15417. |  |
| ML-7 hydrochloride | ML-7 Hcl is a cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM). It also inhibt smooth-muscle myosin light chain kinase, protein kinase C (PKC) and cAMP-dependent protein kinase (PKA). Synonyms: ML-7 HCl; ML-7 hydrochloride; ML-7; ML 7; ML7. Grades: >98%. CAS No. 110448-33-4. Molecular formula: C15H18ClIN2O2S. Mole weight: 452.74. | |
| ML-9 | ML-9 is a myosin light chain kinase (MLCK) inhibitor. It enhances the anticancer activity of docetaxel and has potential application as an adjuvant to existing anticancer chemotherapy. It is used as an attractive tool for targeting autophagy in cancer therapy through dual inhibition of both the Akt pathway and the autophagy. Uses: Ml-9 has potential application as an adjuvant to existing anticancer chemotherapy. Synonyms: ML9; ML 9; 1H-1,4-Diazepine, 1-[(5-chloro-1-naphthalenyl)sulfonyl]hexahydro-. Grades: >98%. CAS No. 110448-31-2. Molecular formula: C15H17ClN2O2S. Mole weight: 324.82. | |
| ML-9 | ML-9 is a selective and potent inhibitor of Akt kinase , inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity [3]. ML-9 inhibits inhibits MLCK, PKA and PKC activity with K i values of 4, 32 and 54 μM, respectively [1]. ML-9 induces autophagy by stimulating autophagosome formation and inhibiting their degradation [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 105637-50-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-100932. | |
| ML 9 hydrochloride | ML 9 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 105637-50-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML-9 hydrochloride | ML-9 hydrochloride is a myosin light chain kinase (MLCK) inhibitor. It enhances the anticancer activity of docetaxel and may be used as an adjuvant to existing anticancer chemotherapy. It inhibits natural killer (NK) cell activity in a dose-dependent manner without affecting target cell binding. It inhibits insulin-induced translocation of both GLUT4 and GLUT1 in a dose-dependent manner. It also inhibits agonist-induced Ca2+ entry into endothelial cells and catecholamine secretion in intact and permeabilized chromaffin cells. It inhibits the catalytic activities of several protein kinases competitively with respect to ATP and exhibited different Ki values toward each protein kinase. It may be a new type of vascular relaxant. Uses: Ml-9 hydrochloride may be used as an adjuvant to existing anticancer chemotherapy. it may be a new type of vascular relaxant. Synonyms: ML9; ML-9; ML 9; ML9 Hydrochloride;ML 9 Hydrochloride; 1-(5-Chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine HCl;1-(5-Chloronaphthalen-1-yl)sulfonyl-1,4-diazepane hydrochloride. Grades: 95%. CAS No. 105637-50-1. Molecular formula: C15H18Cl2N2O2S. Mole weight: 361.29. | |
| MLCK inhibitor peptide | MLCK inhibitor peptide. Group: Biochemicals. Grades: Purified. CAS No. 198694-74-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Mlck inhibitor peptide 18 | MLCK inhibitor peptide 18 is a myosin light chain kinase (MLCK) inhibitor with an IC50 of 50 nM, and inhibits CaM kinase II only at 4000-fold higher concentrations. Group: Inhibitors. Alternative Names: H-RKKYKYRRK-NH2;MYOSIN LIGHT CHAIN KINASE INHIBITOR PEPTIDE 18;MLCK INHIBITOR PEPTIDE 18. CAS No. 224579-74-2. Molecular formula: C60H105N23O11. Mole weight: 1324.62. Purity: 0.9966. Catalog: ACM224579742. | |
| MLCK inhibitor peptide 18 | MLCK inhibitor peptide 18 is a myosin light chain kinase ( MLCK ) inhibitor with an IC 50 of 50 nM, and inhibits CaM kinase II only at 4000-fold higher concentrations. Uses: Scientific research. Group: Peptides. CAS No. 224579-74-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P1029. | |
| MLCK inhibitor peptide 18 | MLCK inhibitor peptide 18. Group: Biochemicals. Grades: Purified. CAS No. 224579-74-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| MLCK inhibitor peptide 18 | A myosin light chain kinase (MLCK) inhibitor (IC50= 50 nM), and inhibits CaM kinase IIonly at 4000-fold higher concentrations. Synonyms: Myosin Light Chain Kinase Inhibitor Peptide 18. Grades: ≥95%. CAS No. 224579-74-2. Molecular formula: C60H105N23O11. Mole weight: 1324.64. | |
| MLCK inhibitor peptide 18 acetate | MLCK inhibitor peptide 18 acetate is a selective competitive myosin light chain kinase (MLCK) inhibitor (IC50 = 50 nM) that inhibits CaM kinase II only at 4000-fold higher concentrations. Synonyms: H-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH2.CH3CO2H; L-arginyl-L-lysyl-L-lysyl-L-tyrosyl-L-lysyl-L-tyrosyl-L-arginyl-L-arginyl-L-lysinamide acetate. Grades: ≥95%. Molecular formula: C62H109N23O13. Mole weight: 1384.67. | |
| MLH3 protein, partial (135-151) | MLH3 protein, partial (135-151) is a 7-aa peptide. MLH3 is a DNA mismatch repair gene associated with mammalian microsatellite instability. | |
| MLi-2 | MLi-2 is a potent, orally available and brain penetrant inhibitor of LRRK2 (IC50 = 0.76 nM) with excellent selectivity that shows >295-fold selectivity for over 300 kinases and a diverse panel of receptors and ion channels. Synonyms: (2R,6S)-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1H-indazol-3-yl]pyrimidin-4-yl]morpholine; MLi-2; MLi 2; MLi2. CAS No. 1627091-47-7. Molecular formula: C21H25N5O2. Mole weight: 379.46. | |
| MLKL Inhibitor, Necrosulfonamide ((E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide, Mixed Lineage Kinase Domain-like Protein Inhibitor, Necrosome Inhibitor II, Necrosulfonamide) | A cell-permeable acrylamide compound that inhibits human, but not murine, MLKL adaptor function via covalent modification of Cys86 and is more potent than Nec-1 in preventing necrotic/necroptotic death in human HT-29 (IC50 = 124nM and 2uM, respectively), being ineffective against necrosis/necroptosis in murine L929 or apoptosis in human RIP3-null Panc-1 cells. Unlike Nec-1, which prevents necrosome formation by blocking RIP1-RIP3 interaction, MLKL prevents the MLKL-RIP1-RIP3 necrosome complex from interacting with further downstream effectors. Group: Biochemicals. Grades: Highly Purified. CAS No. 432531-71-0. Pack Sizes: 25mg. Molecular Formula: C??H??N?O?S?, Primary Target: human MLKL. US Biological Life Sciences. | Worldwide |
| MLN0128 | MLN0128, also known as INK128, is a TORC1/2 inhibitor, is also an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity. TORC1/2 inhibitor INK128 binds to and inhibits both TORC1 and TORC2 complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. TORC1 and 2 are upregulated in some tumors and play an important role in the PI3K/Akt/mTOR signaling pathway, which is frequently dysregulated in human cancers. Synonyms: TAK-228; TAK 228; TAK228; INK128; INK-128; INK 128; MLN0128; MLN 0128; MLN-0128; Sapanisertib. Grades: >98%. CAS No. 1224844-38-5. Molecular formula: C15H15N7O. Mole weight: 309.333. | |
| MLN0905 | MLN0905 is a potent, selective small-molecule PLK1 inhibitor. MLN0905 inhibits cell proliferation in a broad range of human tumor cells including DLBCL cell lines. PLK1 inhibition leads to pharmacodynamic pHisH3 modulation and significant antitumor activity in multiple DLBCL models. These data strongly suggest evaluating PLK1 inhibitors as DLBCL anticancer agents in the clinic. Synonyms: MLN0905; MLN0905; MLN0905. CAS No. 1228960-69-7. Molecular formula: C24H25F3N6S. Mole weight: 486.561. | |
| MLN1117 | MLN1117, also known as INK1117, is a PI3Kα inhibitor which could lead to the apoptosis and growth retardation of tumor cells expressed by PI3K&alpha. IC50: 15 nM. Uses: Mln1117 is a pi3kα inhibitor which could lead to the apoptosis and growth retardation of tumor cells expressed by pi3k&alpha. Synonyms: INK1117; INK-1117; INK 1117; MLN1117; MLN 1117; MLN-1117; TAK-117; TAK 117; TAK117; Serabelisib; [6-(2-amino-1,3-benzoxazol-5-yl)imidazo[1,2-a]pyridin-3-yl]-morpholin-4-ylmethanone;Serabelisib. Grades: 98%. CAS No. 1268454-23-4. Molecular formula: C19H17N5O3. Mole weight: 363.37. | |
| MLN120B | MLN120B is a potent and effective IKKbeta inhibitor. It is currently being explored for treatment of inflammatory diseases such as COPD and asthma. Synonyms: MLN-120B; MLN120B; MLN 120B. Grades: >98%. CAS No. 783348-36-7. Molecular formula: C19H15ClN4O2. Mole weight: 366.8. | |
| MLN2480 | MLN2480 is an oral, selective pan-Raf kinase inhibitor. The Raf kinases (A-Raf, B-Raf and C-Raf) are key regulators of cell proliferation and survival within the mitogen-activated protein kinase (MAPK) pathway. The MAPK pathway is frequently disregulated in human cancers, often via activating mutations of Ras or Raf. Synonyms: TAK-580; TAK 580; TAK580; MLN 2480; MLN-2480; MLN2480; AMG 2112819; AMG2112819; AMG-2112819. Grades: >98%. CAS No. 1096708-71-2. Molecular formula: C17H12Cl2F3N7O2S. Mole weight: 506.29. | |
| MLN 4924 | A potent and selective inhibitor of NAE. Group: Biochemicals. Alternative Names: Sulfamic Acid [ (1S, 2S, 4R) -4- [4- [ [ (1S) -2, 3-dihydro-1H-inden-1-yl] amino] -7H-pyrrolo [2, 3-d] pyrimidin-7-yl] -2-hydroxycyclopentyl] methyl Ester. Grades: Highly Purified. CAS No. 905579-51-3. Pack Sizes: 1mg, 2mg, 5mg, 10mg. US Biological Life Sciences. | Worldwide |
| MLN4924 HCl | MLN4924 HCl is a potent and selective small molecule NEDD8-activating enzyme (NAE) inhibitor with an IC50 of 4.7 nM. Synonyms: MLN4924 HCl; MLN 4924 HCl; MLN-4924 HCl. Grades: >98%. CAS No. 1160295-21-5. Molecular formula: C21H26ClN5O4S. Mole weight: 479.98. | |
| MLN8054 | MLN8054 is a potent, selective and orally available aurora A kinase inhibitor with an IC 50 of 4 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 869363-13-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10180. | |
| MLN8054 | MLN8054 is an aurora kinase inhibitor MLN8054, which is an orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase with potential antineoplastic activity. Auora kinase inhibitor MLN8054 binds to and inhibits Aurora kinase A, resulting in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregration, and inhibition of cell proliferation. Aurora A localizes in mitosis to the spindle poles and to spindle microtubules and is thought to regulate spindle assembly. Aberrant expression of Aurora kinases occurs in a wide variety of cancers, including colon and breast cancers. Synonyms: MLN8054; MLN 8054; MLN-8054. CAS No. 869363-13-3. Molecular formula: C25H15ClF2N4O2. Mole weight: 476.86. | |
| MLN 8054 | An Aurora kinase inhibitor, used to treat patients with advanced solid tumors. Group: Biochemicals. Alternative Names: 4-[[9-Chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic Acid. Grades: Highly Purified. CAS No. 869363-13-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Mln 8054 O-β-D-glucuronide | Heterocyclic Organic Compound. Alternative Names: 1-[4-[[9-Chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoate] β-D-Glucopyranuronic Acid. CAS No. 1203589-02-9. Molecular formula: C31H23ClF2N4O8. Mole weight: 652.99. Catalog: ACM1203589029. | |
| MLN 8237 | Antagonist of Aurora A serine/threonine protein kinase; antineoplastic. Group: Biochemicals. Alternative Names: 4-[[9-Chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxy-benzoic acid; Alisertib. Grades: Highly Purified. CAS No. 1028486-01-2. Pack Sizes: 10mg. Molecular Formula: C27H20ClFN4O4, Molecular Weight: 518.92. US Biological Life Sciences. | Worldwide |
| MLN-9708 | ixazomib is an orally bioavailable second generation proteasome inhibitor (PI) with potential antineoplastic activity. Ixazomib inhibits the activity of the proteasome, blocking the targeted proteolysis normally performed by the proteasome, which results in an accumulation of unwanted or misfolded proteins; disruption of various cell signaling pathways may follow, resulting in the induction of apoptosis. Compared to first generation PIs, second generation PIs may have an improved pharmacokinetic profile with increased potency and less toxicity. Proteasomes are large protease complexes that degrade unneeded or damaged proteins that have been ubiquinated. Synonyms: Ixazomib; MLN-9708; MLN 9708; MLN9708. CAS No. 1201902-80-8. Molecular formula: C20H23BCl2N2O9. Mole weight: 517.12. | |
| M-Loxoprofen | M-Loxoprofen. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1026471-88-4. Molecular Formula: C15H18O3. Mole Weight: 246.31. Catalog: APB1026471884. |  |
| MLR 1023 | MLR 1023. Group: Biochemicals. Grades: Purified. CAS No. 41964-07-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| MLR 1023 | Tolimidone is an allosteric Lyn kinase activator with EC50 value of 63 nM. It has been shown to reduce blood glucose levels in mice. Synonyms: Tolimidone; CP 26,154; CP 26,154; CP 26,154; NSC 314335; MLR-1023; MLR 1023; MLR1023. 5-(3-Methylphenoxy)-2(1H)-pyrimidinone. Grades: ≥99% by HPLC. CAS No. 41964-07-2. Molecular formula: C11H10N2O2. Mole weight: 202.21. | |
| MLR-52 | MLR-52, extracted from Streptomyces sp. AB 1869R-359, is an immunosuppressive protein kinase C inhibitor. And the IC50 (nmol/L) of the mixed lymphocyte response test was 1.9±0.2. Synonyms: 4'-Demethylamino-4',5'-dihydroxystaurosporine; (+)-MLR-52. CAS No. 155416-34-5. Molecular formula: C27H23N3O5. Mole weight: 469.49. | |
| ML RR-S2 CDA | ML RR-S2 CDA, a synthetic CDN-derivative molecule, compared to endogenous and pathogen-derived CDNs, as a attractive compound for anticancer clinical development, it improves both stability and lipophilicity, promoting significantly increased STING signal. Synonyms: 2',3'-c-di-AM(PS)2(Rp,Rp); Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'?5')-, cyclic nucleotide; (R,R)-(2',3')c-diAM(PS)2; (2',3')-Rp,Rp-c-diAMPSS; dithio-(RP, RP)-[cyclic[A(2',5')pA(3',5')p]]; ML RR-S2 CDA (STING-Inducer-1). Grades: ≥95%. CAS No. 1638241-89-0. Molecular formula: C20H24N10O10P2S2. Mole weight: 690.54. | |
| MLS1547 | MLS1547 is a highly efficacious D2 dopamine receptor (D2R) G protein-biased agonist that does not recruit β-arrestin, and is an antagonist of dopamine-stimulated β-arrestin recruitment to the D2 receptor. Group: Agonists. Alternative Names: MLS1547; MLS-1547; MLS 1547; MLS000051547. CAS No. 315698-36-3. Molecular formula: C19H19ClN4O. Mole weight: 354.84. Appearance: Solid powder. Purity: >98%. IUPACName: 5-Chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol. Canonical SMILES: OC1=C2N=CC=CC2=C (Cl)C=C1CN3CCN (C4=NC=CC=C4)CC3. Catalog: ACM315698363. | |
| MLS 1547 | MLS 1547 is a dopamine D2 receptor agonist. It may be used in the combination with antipsychotic drugs. Synonyms: MLS 1547; MLS1547; MLS-1547; 5-Chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol. Grades: ≥98% by HPLC. CAS No. 315698-36-3. Molecular formula: C19H19ClN4O. Mole weight: 354.83. | |
| MLS-573151 | MLS-573151 is a specific and cell-permeable inhibitor of Cdc42, a GTPase of the Rho family. Synonyms: 4-(3,5-Diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide. Grades: ≥98%. CAS No. 10179-57-4. Molecular formula: C21H19N3O2S. Mole weight: 377.5. | |
| ML SA1 | ML SA1. Group: Biochemicals. Grades: Purified. CAS No. 332382-54-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML SA1 | ML SA1 is an activator of TRPML channels. It can induce TRPML-mediated Ca2+ release from lysosomes and reduce cholesterol accumulation in Niemann-Pick type C macrophages. Synonyms: 2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione. Grades: ≥99% by HPLC. CAS No. 332382-54-4. Molecular formula: C22H22N2O3. Mole weight: 362.42. | |
| ML-SI3 | ML-SI3 is an antagonist of the TRPML family of calcium channels. ML-SI3 can prevent lysosomal calcium efflux and has been reported to block downstream TRPML1-mediated induction of autophagy. Synonyms: N- [2- [4- (2-methoxyphenyl) -1-piperazinyl] cyclohexyl] benzenesulfonamide. CAS No. 891016-02-7. Molecular formula: C23H31N3O3S. Mole weight: 429.58. | |
| ML-SI3 | ML-SI3 is a chemical compound which acts as an "antagonist" (i.e. channel blocker) of the TRPML family of calcium channels, with greatest activity at the TRPML1 channel, although it also blocks the related TRPML2 and TRPML3 channels with lower affinity. It is used for research into the role of TRPML1 and its various functions in lysosomes and elsewhere in the body. Group: Antagonists. Alternative Names: ML-SI3; ML SI3; MLSI3; ML SI 3; MLSI-3. CAS No. 891016-02-7. Molecular formula: C23H31N3O3S. Mole weight: 429.58. Appearance: Solid powder. Purity: >98%. IUPACName: N- (2-[4- (2-Methoxyphenyl) -1-piperazinyl]cyclohexyl) benzenesulfonamide. Canonical SMILES: O=S (C1=CC=CC=C1) (NC2C (N3CCN (C4=CC=CC=C4OC)CC3)CCCC2)=O. Catalog: ACM891016027. | |
| MLT-747 | MLT-747 is a potent and selective malt1 peptide cleavage inhibitor. Synonyms: AC-31545; HY-124587; MLT 747; MLT747. Grades: ≥98% by HPLC. CAS No. 2097853-86-4. Molecular formula: C20H21Cl2N7O3. Mole weight: 478.3. | |
| MLT-748 | MLT-748 is a potent and selective malt1 peptide cleavage inhibitor. Synonyms: 1-(5-Chloro-6-(2H-1,2,3-Triazol-2-Yl)Pyridin-3-Yl)-3-(2-Chloro-7-((1R,2R)-1,2-Dimethoxypropyl)Pyrazolo[1,5-A]Pyrimidin-6-Yl)Urea. Grades: ≥98% by HPLC. CAS No. 1832578-30-9. Molecular formula: C19H19Cl2N9O3. Mole weight: 492.3. | |
| Mlu I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 20-fold overdigestion with enzyme 95% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 1000U; 5000U. A↑CGCGT TGCGC↓A. Activity: 20000u.a./ml. Appearance: 10 X SE-buffer O. Storage: -20°C. Form: Liquid. Source: Micrococcus luteus. Pack: 10 mM Tris-HCl (pH 7.5); 100 mM NaCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1133RE. |  |
| Mly113 I | One unit of the enzyme is the amount required to hydrolyze 1 μg of T7 DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 3-fold overdigestion with enzyme more than 80% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 200U; 1000U. GG↑CGCC CCGC↓GG. Activity: 2000u.a./ml. Appearance: 10 X SE-buffer B. Storage: -20°C. Form: Liquid. Source: Micrococcus lylae 113. Pack: 10 mM Tris-HCl (pH 7.5); 50 mM KCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1134RE. | |
| MM 102 | MM 102. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| MM-102 | MM-102 Inhibitor. Uses: Scientific use. Product Category: T8768. CAS No. 1883545-52-5. | |
| MM-102 | MM-102, as a MLL1 mimetic, shows high binding affinities to WDR5 with IC50 of 2.9 nM and Ki of < 1 nM. Synonyms: MM-102; MM102; MM 102; HMTase Inhibitor IX. Grades:>98%. CAS No. 1417329-24-8. Molecular formula: C35H49F2N7O4. Mole weight: 669.8. | |
| MM-102 Trifluoroacetate | MM102 is a WDR5/MLL interaction inhibitor with IC50 value of 2.4 nM. It can inhibit cell growth and induce apoptosis in leukemia cells harbouring MLL1 fusion proteins. Synonyms: MM 102; MM102; MM-102; 1-[[(2S)-5-[(Aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]-cyclopentanecarboxamide trifluoroacetate. Grades: ≥98% by HPLC. CAS No. 1883545-52-5. Molecular formula: C35H49F2N7O4.CF3CO2H. Mole weight: 783.83. | |
| MM 11253 | MM 11253 is a RARγ antagonist. It can block the growth inhibitory ability of RARγ-selective agonists in squamous cell carcinoma (SCC)-25 cells. Synonyms: MM 11253; MM-11253; MM11253. 6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylic acid. Grades: ≥98% by HPLC. CAS No. 345952-44-5. Molecular formula: C28H30O2S2. Mole weight: 462.67. | |
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