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| Product | Description | |
|---|---|---|
| MK-4101 | MK-4101 is a potent and selective SMO Inhibitor of the Hedgehog Pathway with anti-tumor activity. MK-4101 targets the Hh pathway in tumor cells, showing the maximum inhibitory effect on Gli1 MK-4101 also induced deregulation of cell cycle and block of DNA replication in tumors. Synonyms: 5-(3,3-Difluorocyclobutyl)-3-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl]bicyclo[2.2.2]oct-1-yl]-1,2,4-oxadiazole; MK-4101; MK 4101; MK4101. Grades: >98%. CAS No. 935273-79-3. Molecular formula: C24H24F5N5O. Mole weight: 493.48. |  |
| MK 436 | MK436 is an anti-protozoal drug has been found to be effective against Trypanosoma cruzi infections. Uses: A therapeutic agent and an anti-protozoal drug. Synonyms: MK-436; MK 436; MK436; 3-(1-methyl-5-nitro-1H-imidazol-2-yl)-3a,4,5,6,7,7a-hexahydrobenzo[d]isoxazole. Grades: ≥98%. CAS No. 33450-08-7. Molecular formula: C11H14N4O3. Mole weight: 250.10. | |
| MK-467 | MK-467 is a peripheral Alpha2 -adrenoceptor antagonist originated by Merck & Co. It can dose-dependently attenuate the bradycardia associated with dexmedetomidine, and shorten the sedative effect without altering its quality. Clinical for Diabetes mellitus in USA was discontinued in 1994. Uses: Diabetes mellitus. Synonyms: MK-467; MK 467; MK467; UNII-66932R910R; N-(2-((2R,12bS)-2'-oxo-1,3,4,6,7,12b-hexahydrospiro[benzofuro[2,3-a]quinolizine-2,4'-imidazolidin]-3'-yl)ethyl)methanesulfonamide hydrochloride. Grades: 98%. CAS No. 130466-38-5. Molecular formula: C20H27ClN4O4S. Mole weight: 454.98. | |
| MK-4827 hydrochloride | Cas No. 1038915-64-8. | |
| MK-4827 (R-enantiomer) | MK-4827 (R-enantiomer) is the R form of MK-4827, which is a PARP inhibitor developed for the treatment of ovarian cancer. Synonyms: (R)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide; Niraparib R-enantiomer; MK4827 R-enantiomer; MK 4827 R-enantiomer; MK-4827 R-enantiomer. Grades: > 98%. CAS No. 1038915-58-0. Molecular formula: C19H20N4O. Mole weight: 320.396. | |
| MK-4827 tosylate | MK-4827 tosylate is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM. It has a great activity in cancer cells with mutant BRCA-1 and BRCA-2, >330-fold selective against PARP3, V-PARP and Tank1. Synonyms: (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide 4-methylbenzenesulfonate; MK-4827; MK-4827; MK4827; MK4827-tosylate; Niraparib tosylate. Grades: >98%. CAS No. 1038915-73-9. Molecular formula: C26H28N4O4S. Mole weight: 492.59. | |
| MK 499 | MK 499, also know as L706000, has been found to be a potassium channel antagonist that has been once studied the activity in the treatment of arrhythmias. The Phase II trail of it has already been discontinued by Merck. Synonyms: L 706000; L706000; L706000; MK 499; MK499; MK499. L 706000; L-706000; L-706,000; N-[1'-(6-cyano-1,2,3,4-tetrahydronaphthalen-2-yl)-4-hydroxyspiro[3,4-dihydrochromene-2,4'-piperidine]-6-yl]methanesulfonamide. Grades: 98%. CAS No. 150481-98-4. Molecular formula: C25H29N3O4S. Mole weight: 467.58. | |
| MK-5046 | MK-5046, the first BRS-3 agonist with properties suitable for use in larger mammals, has strong selectivity when binding to BRS-3 receptor. It was developed by Merck as a new approach to the treatment of obesity and still under phase I trial.(mouse Ki = 1. Uses: Mk-5046, the first brs-3 agonist with properties suitable for use in larger mammals, has strong selectivity when binding to brs-3 receptor. Synonyms: MK5046; MK-5046; MK 5046. (2R)-1, 1, 1-trifluoro-2-(4-pyrazol-1-ylphenyl)-3-[5-[[1-(trifluoromethyl)cyclopropyl]methyl]-1H-imidazol-2-yl]propan-2-ol; MK5046peak2; SCHEMBL502524; UJINBEQCDMOAHM-GOSISDBHSA-N; KB-78904; (2R)-1, 1, 1-trifluoro-2-[4-(1H-pyrazol-1-yl)phenyl]-3-(4-{[1-(trifluorom. Grades: 95%. CAS No. 1022152-70-0. Molecular formula: C20H18F6N4O. Mole weight: 444.37. | |
| MK-5172 | Grazoprevir is a hepatitis C virus protease inhibitor developed for the treatment of hepatitis C. It suppresses NS3 and NS4A, which play a role in the virus splitting its polyprotein into the functional virus proteins. Grazoprevir is often used in combination with elbasvir or ribavirin. Uses: Antiviral agents. Synonyms: Cyclopropanecarboxamide, N-[[[ (1R, 2R) -2-[5- (3-hydroxy-6-methoxy-2-quinoxalinyl) pentyl]cyclopropyl]oxy]carbonyl]-3-methyl-L-valyl- (4R) -4-hydroxy-L-prolyl-1-amino-N- (cyclopropylsulfonyl) -2-ethenyl-, cyclic (1?2)-ether, (1R,2S)-; Grazoprevir; (1R, 2S) -N-[[[ (1R, 2R) -2-[5- (3-Hydroxy-6-methoxy-2-quinoxalinyl) pentyl]cyclopropyl]oxy]carbonyl]-3-methyl-L-valyl- (4R) -4-hydroxy-L-prolyl-1-amino-N- (cyclopropylsulfonyl) -2-ethenylcyclopropanecarboxamide Cyclic (1?2)-Ether. Grades: >98%. CAS No. 1350514-68-9. Molecular formula: C38H50N6O9S. Mole weight: 766.91. | |
| MK-5172 hydrate | In biochemical assays, MK-5172 was effective against a panel of major genotypes and variants engineered with common resistant mutations observed in clinical studies with other NS3/4a protease inhibitors. In the replicon assay, MK-5172 demonstrated subnanomolar to low-nanomolar EC50s against genotypes 1a, 1b, and 2a. In rats, MK-5172 showed a plasma clearance of 28 ml/min/kg and plasma half-life of 1.4 hr. When dosed p.o. at 5 mg/kg, the plasma exposure of MK-5172 was good with an AUC of 0.7 uM.hr. The liver exposure of the compound was quite good (23 uM at 4 hr), and MK-5172 remained in liver 24 hr after a single p.o. 5 mg/kg dose. At 24 hr, the liver concentration of MK-5172 was 0.2 uM, which was over 25-fold higher than the IC50 in the replicon assay with 50% NHS. When dosed to dogs, MK-5172 showed low clearance of 5 ml/min/kg and a 3 hr half-life after i.v. 2 mg/kg dosing and had good plasma exposure (AUC=0.4 uM.hr) after a p.o. 1 mg/kg dose. Uses: Antiviral agents. Synonyms: (33R,35S,91R,92R,5S)-5-(tert-butyl)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphane-35-carboxamide hydrate; MK-5172; MK 5172; MK5172; Grazoprevir; Grazoprevir hydrate; trade name: Zepatier?. Grades: >98%. CAS No. 1350462-55-3. Molecular formula: C38H52N6O10S. Mole weight: 784.92. | |
| MK-5172 intermediate | Cas No. 1206524-85-7. | |
| MK-5172 potassium salt | In biochemical assays, MK-5172 was effective against a panel of major genotypes and variants engineered with common resistant mutations observed in clinical studies with other NS3/4a protease inhibitors. In the replicon assay, MK-5172 demonstrated subnanomolar to low-nanomolar EC50s against genotypes 1a, 1b, and 2a. In rats, MK-5172 showed a plasma clearance of 28 ml/min/kg and plasma half-life of 1.4 hr. When dosed p.o. at 5 mg/kg, the plasma exposure of MK-5172 was good with an AUC of 0.7 uM.hr. The liver exposure of the compound was quite good (23 uM at 4 hr), and MK-5172 remained in liver 24 hr after a single p.o. 5 mg/kg dose. At 24 hr, the liver concentration of MK-5172 was 0.2 uM, which was over 25-fold higher than the IC50 in the replicon assay with 50% NHS. When dosed to dogs, MK-5172 showed low clearance of 5 ml/min/kg and a 3 hr half-life after i.v. 2 mg/kg dosing and had good plasma exposure (AUC=0.4 uM.hr) after a p.o. 1 mg/kg dose. Synonyms: Grazoprevir potassium salt; MK5172 potassium salt; MK 5172 potassium salt. Grades: >98%. CAS No. 1206524-86-8. Molecular formula: C38H49KN6O9S. Mole weight: 804.99. | |
| MK-5172 sodium salt | In biochemical assays, MK-5172 was effective against a panel of major genotypes and variants engineered with common resistant mutations observed in clinical studies with other NS3/4a protease inhibitors. In the replicon assay, MK-5172 demonstrated subnanomolar to low-nanomolar EC50s against genotypes 1a, 1b, and 2a. In rats, MK-5172 showed a plasma clearance of 28 ml/min/kg and plasma half-life of 1.4 hr. When dosed p.o. at 5 mg/kg, the plasma exposure of MK-5172 was good with an AUC of 0.7 uM.hr. The liver exposure of the compound was quite good (23 uM at 4 hr), and MK-5172 remained in liver 24 hr after a single p.o. 5 mg/kg dose. At 24 hr, the liver concentration of MK-5172 was 0.2 uM, which was over 25-fold higher than the IC50 in the replicon assay with 50% NHS. When dosed to dogs, MK-5172 showed low clearance of 5 ml/min/kg and a 3 hr half-life after i.v. 2 mg/kg dosing and had good plasma exposure (AUC=0.4 uM.hr) after a p.o. 1 mg/kg dose. Synonyms: Grazoprevir sodium salt; MK5172 sodium salt; MK 5172 sodium salt. Grades: >98%. CAS No. 1425038-27-2. Molecular formula: C38H49N6NaO9S. Mole weight: 788.89. | |
| MK-5198 | MK-5108 is a novel small molecule with potent inhibitory activity against Aurora-A kinase. Although most of the Aurora-kinase inhibitors target both Aurora-A and Aurora-B, MK-5108 specifically inhibited Aurora-A kinase in a panel of protein kinase assays. Inhibition of Aurora-A by MK-5108 in cultured cells induced cell cycle arrest at the G(2)-M phase in flow cytometry analysis. The effect was confirmed by the accumulation of cells with expression of phosphorylated Histone H3 and inhibition of Aurora-A autophosphorylation by immunostaining assays. MK-5108 also induced phosphorylated Histone H3 in skin and xenograft tumor tissues in a nude rat xenograft model. MK-5108 inhibited growth of human tumor cell lines in culture and in different xenograft models. Furthermore, the combination of MK-5108 and docetaxel showed enhanced antitumor activities compared with control and docetaxel alone-treated animals without exacerbating the adverse effects of docetaxel. MK-5108 is currently tested in clinical trials and offers a new therapeutic approach to combat human cancers as a single agent or in combination with existing taxane therapies. Synonyms: MK5108; MK-5108; MK 5108; VX689; VX 689; VX-689. Grades: >98%. CAS No. 1010085-13-8. Molecular formula: C22H21ClFN3O3S. Mole weight: 461.94. | |
| Mk-571 | Heterocyclic Organic Compound. CAS No. 115104-28-4. Molecular formula: C26H26ClN2O3S2.Na. Mole weight: 515.1. Catalog: ACM115104284. |  |
| MK 571 | MK-571 is a CysLT1 receptor antagonist. It can be used for the treatment of respiratory diseases. Uses: Leukotriene antagonists. Synonyms: MK 571; MK571; MK-571; 3-[[[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propanoic acid. Grades: ≥98% by HPLC. CAS No. 115104-28-4. Molecular formula: C26H27ClN2O3S2. Mole weight: 515.09. | |
| MK 571 | MK 571. Group: Biochemicals. Grades: Purified. CAS No. 115104-28-4. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| MK-571 | A receptor antagonist for the treatment of respiratory diseases. Cysteinyl leukotriene receptor antagonist MK-571 alters bronchoalveolar lavage fluid proteome in asthma. Group: Biochemicals. Alternative Names: 3- [ [ [3- [ (1E) -2- (7-Chloro-2-quinolinyl) ethenyl] phenyl] [ [3- (dimethylamino) -3-oxopropyl] thio] methyl] thio] propanoic Acid. Grades: Highly Purified. CAS No. 115104-28-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| MK-571 | MK-571 (L-660711) is an orally active, potent and selective competitive leukotriene D 4 (LTD 4 ) receptor antagonist, with K i values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 is also a MRP4 and ABCC1 (MRP1) inhibitor. MK-571 inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: L-660711. CAS No. 115104-28-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19989. |  |
| Mk-571 methyl ester | Heterocyclic Organic Compound. Alternative Names: 3-[[[3-[ (1E) -2- (7-Chloro-2-quinolinyl) ethenyl]phenyl][[3- (dimethylamino) -3-oxopropyl]thio]methyl]thio]propanoic Acid Methyl Ester. CAS No. 120443-15-4. Molecular formula: C27H29ClN2O3S2. Mole weight: 529.11. Appearance: Yellow Oil. Purity: 0.96. IUPACName: methyl 3- [ [3- [ (E) -2- (7-chloroquinolin-2-yl) ethenyl] phenyl] - [3- (dimethylamino) -3-oxopropyl] sulfanylmethyl] sulfanylpropanoate. Canonical SMILES: CN (C)C (=O)CCSC (C1=CC=CC (=C1)C=CC2=NC3=C (C=CC (=C3)Cl)C=C2)SCCC (=O)OC. Catalog: ACM120443154. | |
| MK-571 Methyl Ester | Precursor to MK-571. Group: Biochemicals. Alternative Names: 3- [ [ [3- [ (1E) -2- (7-Chloro-2-quinolinyl) ethenyl] phenyl] [ [3- (dimethylamino) -3-oxopropyl] thio] methyl] thio] propanoic Acid Methyl Ester. Grades: Highly Purified. CAS No. 120443-15-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| MK-571 sodium | MK-571 (L-660711) sodium is an orally active, potent and selective competitive leukotriene D 4 (LTD 4 ) receptor antagonist, with K i values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 sodium is also a inhibitor of multidrug resistance-associated protein MRP4 (ABCC4) and ABCC1 (MRP1). MK-571 sodium inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: L-660711 sodium. CAS No. 115103-85-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-19989A. | |
| MK-571 sodium salt | The sodium salt hydrate of MK-571 which is an effective antagonist of CysLT1 receptor and an inhibitor of MRP1. Uses: Bronchodilator agents. Synonyms: sodium (E) -3- ( ( (3- (2- (7-chloroquinolin-2-yl) vinyl) phenyl) ( (3- (dimethylamino) -3-oxopropyl) thio) methyl) thio) propanoate; MK-571; MK 571; MK571; MK-571 sodium salt; L-660,711; L660,711; L 660,711; L-660711; L660711; L 660711. Grades: 95%. CAS No. 115103-85-0. Molecular formula: C26H26ClN2NaO3S2. Mole weight: 537.07. | |
| MK-571 sodium salt | Selective leukotriene LTD4 receptor antagonist. Potent MRP1 inhibitor. Antinociceptive. Group: Biochemicals. Grades: Highly Purified. CAS No. 115104-28-4. Pack Sizes: 5mg, 25mg. Molecular Formula: C26H26ClN2O3S2?Na. US Biological Life Sciences. | Worldwide |
| MK591 | Quiflapon is a synthetic compound which specifically inhibits the activity of 5-Lox and is currently under development for the treatment of asthma. Also, Quiflapon, a leukotriene biosynthesis inhibitor, induces apoptosis in prostate cancer cells. Synonyms: Quiflapon sodium; MK-591; MK 591. Grades: >98%. CAS No. 147030-01-1. Molecular formula: C34H34ClN2NaO3S. Mole weight: 609.15. | |
| MK-6240 | MK-6240 is a tau positron emission tomography (PET) tracer for neurofibrillary tangles (NFTs) , exhibiting high specificity and selectivity for binding to NFTs [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1841078-87-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101186. | |
| MK6-83 | MK6-83. Group: Biochemicals. Grades: Purified. CAS No. 1062271-24-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| MK6-83 | MK6-83 is a transient receptor potential channel ML3 activator with EC50 value of 110 nM. It can restore endolysosomal trafficking and zinc homeostasis in lysosomes of mucolipidosis type IV mutant fibroblasts. Synonyms: MK6-83; MK6 83; MK683; 5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide. Grades: ≥98% by HPLC. CAS No. 1062271-24-2. Molecular formula: C16H20N2O2S2. Mole weight: 336.47. | |
| MK-6892 | MK-6892 is a highly potential GPR109A agonist. Synonyms: MK6892; MK 6892; MK-6892. Grades: >98%. CAS No. 917910-45-3. Molecular formula: C19H22N4O5. Mole weight: 386.4. | |
| MK-711 | MK-711 is used as a potential bioactive agent. Uses: Mk-711 is used as a potential bioactive agent. Synonyms: MK 711; MK711; 10,11-Dihydro-5-(1-methyl-4-piperidinylidene)-5H-dibenzo(a,d)cycloheptene-3-carboxylic acid; 5-(1-methylpiperidin-4-ylidene)-10,11-dihydro-5H-dibenzo[a,d][7]annulene-3-carboxylic acid. Grades: 98%. CAS No. 63141-67-3. Molecular formula: C22H23NO2. Mole weight: 333.43. | |
| MK-7145 | This active molecular is a selective renal outer medullary potassium channel (RMOK) inhibitor originated by Merck Sharp & Dohme for the treatment of hypertension and heart failure. RMOK is an ATP-dependent potassium channel that transports potassium out of cells. MK-7145 is selective against other cardiac ion channels such as Cav1.2 and Nav1.5 with IC50 value > 30 μM. MK-7145 is the first small molecule ROMK inhibitor to enter clinical development. But in Feb 2015, Merck terminated a phase I trial in Hypertension in Australia and New Zealand. Uses: Hypertension and heart failure. Synonyms: MK-7145; MK 7145; MK7145; 5,5'-((1R,1'R)-piperazine-1,4-diylbis(1-hydroxyethane-2,1-diyl))bis(4-methylisobenzofuran-1(3H)-one);1255204-85-3 (2HCl). Grades: 98%. CAS No. 1255204-84-2. Molecular formula: C26H30N2O6. Mole weight: 466.53. | |
| MK-7145 dihydrochloride | MK-7145 is a potent, selective and orally active ROMK inhibitor for the treatment of hypertension and heart failure. MK-7145 is selective against other cardiac ion channels such as Cav1.2 and Nav1.5 (IC50 > 30 μM). Synonyms: MK-7145 dihydrochloride; MK 7145 dihydrochloride; MK7145 dihydrochloride. Grades: 98%. CAS No. 1255204-85-3. Molecular formula: C26H30N2O6.2HCl. Mole weight: 544.534. | |
| MK-7246 | MK-7246 is a potent and selective CRTH2 antagonist with a Ki of 2.5±0.5 nM. It is used for the treatment of respiratory diseases. Group: Fluorinated apis. Alternative Names: Pyrido(1,2-a)indole-10-acetic acid, 7-(((4-fluorophenyl)sulfonyl)methylamino)-6,7,8,9-tetrahydro-, (7R)-. CAS No. 1218918-62-7. Molecular formula: C21H21FN2O4S. Mole weight: 416.47. Appearance: White to off-white solid powder. Purity: >98%. IUPACName: 2-[(7R)-7-[(4-fluorophenyl)sulfonyl-methylamino]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetic acid. Catalog: OFC1218918627. | |
| MK-7246 | This active molecular is a selective chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) antagonist and is used for the treatment of respiratory tract disorders originated by Merck & Co. CRTH2 is a G protein-coupled receptor that has been reported to modulate inflammatory responses in animal models of asthma, allergic rhinitis and atopic dermatitis. No recent reports of development identified for phase-I development in Respiratory-tract-disorders in USA were published yet. Uses: Respiratory tract disorders. Synonyms: MK-7246; MK 7246; MK7246; (7R)-7-[[(4-Fluorophenyl)sulfonyl]methylamino]-6,7,8,9-tetrahydro-pyrido[1,2-a]indole-10-acetic Acid. Grades: 98%. CAS No. 1218918-62-7. Molecular formula: C21H21FN2O4S. Mole weight: 416.47. | |
| MK-761 | MK-761 has beta adrenoceptor antagonist and vasodilating properties in a single molecule. It has beta adrenoceptor blocking activity in the isolated cat heart papillary muscle and isolated rat atria in vitro. Uses: Mk-761 has beta adrenoceptor antagonist and vasodilating properties. Synonyms: MK-761; MK 761; MK761;(S)-2-(3-(tert-butylamino)-2-hydroxypropoxy)nicotinonitrile;2-[3-(Tert-butylamino)-2-hydroxypropoxy]pyridine-3-carbonitrile. Grades: 98%. CAS No. 65321-41-7. Molecular formula: C13H19N3O2. Mole weight: 249.31. | |
| MK-761 free base | MK-761 free base is a potent and orally active β2-adrenergic blocker. MK-761 free base shows antihypertensive and positive inotropic effects. MK-761 free base shows vasodilating properties [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 65321-41-7. Pack Sizes: 1 mg. Product ID: HY-123449. | |
| MK-7622 | MK-7622 is a cholinesterase inhibitor under evaluation for the treatment of Alzheimer's disease. No studies have been published on this compound in the peer-reviewed literature or other publicly available documents. I. Synonyms: MK7622; MK 7622; MK-7622. Grades: 98%. CAS No. 1227923-29-6. Molecular formula: C25H25N3O2. Mole weight: 399.49. | |
| MK-771 | MK-771 is an analog of the Thyrotropin Releasing Hormone (TRH). It is a therapeutic agent. It may be useful in combating some of the withdrawal symptoms in opiate-dependent subjects. Uses: Mk-771 is a therapeutic agent. it may be useful in combating some of the withdrawal symptoms in opiate-dependent subjects. Synonyms: MK771; MK 771; (S)-3-((S)-3-(1H-imidazol-4-yl)-2-((S)-6-oxopiperidine-2-carboxamido)propanoyl)thiazolidine-4-carboxamide. Grades: 98%. CAS No. 66537-55-1. Molecular formula: C16H22N6O4S. Mole weight: 394.45. | |
| MK7725 | MK7725 is a potent, selective bombesin receptor subtype-3 agonist. It is used for the treatment of obesity. Uses: Mk7725 is used for the treatment of obesity. Synonyms: MK7725; MK 7725; MK-7725; 2-[3-[6-[4-(trifluoromethoxy)phenyl]sulfonyl-2-(trifluoromethyl)-5,11-dihydropyrido[3,2-c][1,5]benzodiazepin-7-yl]-1,2,4-oxadiazol-5-yl]propan-2-ol. Grades: >98 %. CAS No. 1034152-95-8. Molecular formula: C25H19F6N5O5S. Mole weight: 615.50. | |
| MK785 | MK785, an imidazol derivative, has been found to inhibit the formation of aortic histamine through influencing the aortic histidine decarboxylase at some extent. Synonyms: 2-hydrazinyl-3-(1h-imidazol-5-yl)propanoic acid; MK-785; MK 785; MK785; AC1Q5SMC; 2-Hydrazino-3-(4(5)-imidazole)propionic acid. Grades: 98%. CAS No. 14760-71-5. Molecular formula: C6H10N4O2. Mole weight: 170.17. | |
| MK789 | MK-789 is a dehydropeptidase I inhibitor. Synonyms: MK789; MK 789; MK-789; (E)-2-(2,2-dimethylcyclopropanecarboxamido)oct-2-enoic acid. Grades: 98%. CAS No. 85394-14-5. Molecular formula: C14H23NO3. Mole weight: 253.34. | |
| MK-7924 | MK-7924, isolated from Coronophora gregaria, is an antibiotic with nematocidal effect. And the reproductive growth tests showed that the effective concentration against Caenorhabditis elegane was 100 μg/mL. Molecular formula: C34H58O13. Mole weight: 674.81. | |
| MK800-62F1 | MK800-62F1 is produced by the strain of Streptomyces diastochromogenes MK 800-62F1. It is used to inhibit H2O2-induced apoptosis in MS-1 cells (NCI-H) and Jurkat cells (TCL-H), and camptothecin-induced apoptosis in Jurkat cells. Molecular formula: C35H58O8. Mole weight: 606.83. | |
| MK-8033 | MK8033 is a novel and specific dual ATP competitive c-Met/Ron inhibitor (IC50=1 nM Wt c-Met) under investigation as a treatment for cancer. Synonyms: MK-8033; MK 8033; MK8033. Grades: >98%. CAS No. 1001917-37-8. Molecular formula: C25H21N5O3S. Mole weight: 471.53. | |
| MK-8033 hydrochloride | MK-8033 binds 3-fold more tightly to phosphorylated c-Met kinase domain (Kd= 3.2 nM) than to its unphosphorylated counterpart (Kd = 10.4 nM). Signigicantly, MK-8033 potently inhibits kinase activity of three oncogenic c-Met activation loop mutants, Y1230C, Y1230H, and Y1235D (IC50s ranging from 0.6 to 1 nM at 50 uM ATP) in addition to other c-Met activating mutants N1100Y and M1250T. MK-8033 potently inhibited GTL-16 proliferation with an IC50 of 582 ± 30 nM. By contrast the HCT116 cell line, which does not harbor basal c-Met activation, was not inhibited by MK-8033 (IC50 > 10000 nM) [1]. MK-8033 radiosensitized the high-c-Met-expressing EBC-1 and H1993 cells but not the low-c-Met...anized 1 h after dosing and tested for p-Met (Y1349) in tumors and MK-8033 concentrations in plasma. At 100 mg/kg,essentially complete inhibition of p-Met (Y1349) was achieved. An in vivo IC50 of 1.3 uM was deduced from the relationship between plasma MK-8033 level and Met pY1349. Treatment with escalating dosed of MK-8033 for 21 days lead to antitumor efficacies in a dose-dependent manner. Dosing at 3, 10, 30, and 100 mg/kg resulted in 22, 18, 57, and 86% tumor growth inhibition, respectively, relative to tumor from vehicle-treated mice. Synonyms: MK8033 hydrochloride; MK 8033 hydrochloride. Grades: >98%. CAS No. 1283000-43-0. Molecular formula: C25H22ClN5O3S. Mole weight: 507.99. | |
| MK-8189 | MK-8189 is a potent, orally active and selective PDE10A inhibitor with a K i value of 29 pM. MK-8189 can be used in research of schizophrenia [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1424371-93-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153093. | |
| MK-8245 | MK-8245 is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. Synonyms: 4-(2-Bromo-5-fluorophenoxy)-1-[5-(2H-tetrazol-5-yl)-3-isoxazolyl]piperidine; MK-8245; MK8245; MK8245. Grades: 0.98. CAS No. 1030612-90-8. Molecular formula: C17H16BrFN6O4. Mole weight: 467.25. | |
| MK-8245 | MK-8245 is a potent, liver-targeted stearoyl-CoA desaturase (SCD) inhibitor, with IC 50 s of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with antidiabetic and antidyslipidemic efficacy [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1030612-90-8. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13070. | |
| MK-8245 | MK-8245. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1030612-90-8. Molecular Formula: C17H16BrFN6O4. Mole Weight: 467.254. Catalog: APB1030612908. |  |
| MK-8245 Trifluoroacetate | MK-8245 trifluoroacetate is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. Uses: Scientific research. Group: Signaling pathways. CAS No. 1415559-41-9. Pack Sizes: 1 mg. Product ID: HY-13077. | |
| MK-8245 Trifluoroacetate | MK-8245 Trifluoroacetate, a phenoxy piperidine isoxazole derivative, is a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor that has the potential for treatment of dyslipidemia and diabetes. IC50: human SCD1= 1 nM; rat SCD1 and mouse SCD1= 3 nM. Uses: Antidiabetic; antidyslipidemic. Synonyms: MK-8245 Trifluoroacetate; MK 8245 Trifluoroacetate; MK8245 Trifluoroacetate; 2-[5-[3-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,2-oxazol-5-yl]tetrazol-2-yl]acetic acid;2,2,2-trifluoroacetic acid; MK-8245 (Trifluoroacetate); 1415559-41-9; 2,2,2-Trifluoroacetic acid compound with 2-(5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-Yl. CAS No. 1415559-41-9. Molecular formula: C19H17BrF4N6O6. Mole weight: 581.28. | |
| MK-8353 | MK-8353 is an orally available ERK1/2 inhibitor. It exhibited antitumor activity in patients with BRAFV600-mutant melanoma. Synonyms: (3S)-3-(methylthio)-1-[2-[4-[4-(1-methyl-1,2,4-triazol-3-yl)phenyl]-3,6-dihydro-2H-pyridin-1-yl]-2-oxoethyl]-N-[3-(6-propan-2-yloxy-3-pyridinyl)-1H-indazol-5-yl]-3-pyrrolidinecarboxamide. CAS No. 1184173-73-6. Molecular formula: C37H41N9O3S. Mole weight: 691.84. | |
| MK-8527 | MK-8527 is an orally active HIV inhibitor and nucleoside reverse transcriptase translocation inhibitor ( NRTTI ) with antiviral activity. MK-8527 has a similar inhibitory mechanism to ISL (HY-104012) [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1810869-23-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158128. | |
| MK-8617 | MK-8617 is a potent and selective pan-inhibitor of Hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) (PHD1: IC50 = 1.0 nM; PHD2: IC50 =1.0nM; PHD3: IC50 = 14nM) commonly used for the treatment of Anemia, a disease caused by inadequate red blood cells (RBCs) or hemoglobin (Hb). Synonyms: MK-8617; MK 8617; MK8617; UNII-39RRC0G27V; 39RRC0G27V; SCHEMBL3407165; AKOS030622836; N-[bis(4-methoxyphenyl)methyl]-6-oxo-2-pyridazin-3-yl-1H-pyrimidine-5-carboxamide. Grades: 99.39 %. CAS No. 1187990-87-9. Molecular formula: C24H21N5O4. Mole weight: 443.45. | |
| MK-8718 | MK-8718 has been found to be a HIV protease inhibitor and could be studied in HIV research. Synonyms: MK-8718; MK 8718; MK8718; ((3S,6R)-6-(2-(3-((2S,3S)-2-amino-3-(4-chlorophenyl)-3-(3,5-difluorophenyl)propanamido)-5-fluoropyridin-4-yl)ethyl)morpholin-3-yl)methyl (2,2,2-trifluoroethyl)carbamate. Grades: 98%. CAS No. 1582729-24-5. Molecular formula: C30H30ClF6N5O4. Mole weight: 674.04. | |
| MK-8718 HCl | The hydrochloride salt form of MK-8718 which has been found to be a HIV protease inhibitor and could be studied in HIV research. Synonyms: MK-8718 HCl; MK 8718 HCl; MK8718 HCl. Grades: 98%. CAS No. 1582732-29-3. Molecular formula: C30H31Cl2F6N5O4. Mole weight: 710.54. | |
| MK-8722 | MK-8722 is a potent pan-AMPK activator. MK-8722 improves glucose homeostasis but induces cardiac hypertrophy. In rodents and rhesus monkeys, MK-8722-mediated AMPK activation in skeletal muscle induced robust, durable, insulin-independent glucose uptake and glycogen synthesis, with resultant improvements in glycemia and no evidence of hypoglycemia. These effects translated across species, including diabetic rhesus monkeys, but manifested with concomitant cardiac hypertrophy and increased cardiac glycogen without apparent functional sequelae. Group: Activators. Alternative Names: MK-8722; MK 8722; MK8722. CAS No. 1394371-71-1. Molecular formula: C24H20ClN3O4. Mole weight: 449.89. Appearance: Solid powder. Purity: >98%. IUPACName: (3R,3aR,6R,6aR)-6-((6-([1,1'-biphenyl]-4-yl)-7-chloro-3H-imidazo[4,5-b]pyridin-2-yl)oxy)hexahydrofuro[3,2-b]furan-3-ol. Canonical SMILES: ClC1=C2C (NC (O[C@@H]3CO[C@@]4 ([H])[C@]3 ([H])OC[C@H]4O)=N2)=NC=C1C5=CC=C (C6=CC=CC=C6)C=C5. Catalog: ACM1394371711. | |
| MK-8722 | MK-8722 is a potent pan-AMPK activator that improves glucose homeostasis but induces cardiac hypertrophy. AMPK has long been of interest as a target for the treatment of Type 2 Diabetes Mellitus. Synonyms: MK 8722; MK8722. CAS No. 1394371-71-1. Molecular formula: C24H20ClN3O4. Mole weight: 449.9. | |
| MK-8745 | MK-8745 is a novel Aurora-A specific inhibitor. MK8745 induced apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages. Exposure of p53 wild-type cells to MK8745 resulted in the induction of p53 phosphorylation (ser15) and an increase in p53 protein expression. p53-dependent apoptosis by MK8745 was further confirmed in HCT 116 p53(-/-) cells transfected with wild-type p53. Synonyms: MK-8745; MK 8745; MK8745. Grades: 0.98. CAS No. 885325-71-3. Molecular formula: C20H19ClFN5OS. Mole weight: 431.91416. | |
| Mk-886 | Heterocyclic Organic Compound. Alternative Names: MK-886 sodium salt hydrate; MK-886 sodium hydrate; MK-886; Lopac-M-2692; MK-886 sodium salt. CAS No. 118427-55-7. Molecular formula: C27H33ClNNaO2S. Mole weight: 494.06. Purity: 0.96. IUPACName: sodium;3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-2,2-dimethylpropanoate. Canonical SMILES: CC (C)C1=CC2=C (C=C1)N (C (=C2SC (C) (C)C)CC (C) (C)C (=O)[O-])CC3=CC=C (C=C3)Cl. [Na+]. Catalog: ACM118427557. | |
| MK 886 | MK 886. Group: Biochemicals. Grades: Purified. CAS No. 118414-82-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| MK-886 | MK-886 (L 663536) is a potent, cell-permeable and orally active FLAP ( IC 50 of 30 nM) and leukotriene biosynthesis ( IC 50 s of 3 nM and 1.1 μM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 is also a non-competitive PPARα antagonist and can induce apoptosis [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: L 663536. CAS No. 118414-82-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14166. | |
| MK-886 | This active molecular is a leukotriene antagonist with the IC50 of 3 nM in human polymorphonuclear leukocytes. MK-886 also inhibits PPARα activation. Inhibition of 5-lipoxygenase-activating protein (FLAP) leads to inhibited 5-lipoxygenase (5-LOX), and this may help in treating atherosclerosis. MK-886 and Celecoxib have an inhibitory effect on the growth of pancreatic cancer cell line SW1990 and angiogenesis. In Mar 1996, an animal study had been added to the Ischaemic Heart Disease pharmacodynamics section. Uses: Ischaemic heart disease. Synonyms: MK-886; MK886; MK 886; L-663,536; L663,536; L 663,536; L-663536; L663536; L 663536; 3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-2,2-dimethylpropanoic acid,L-663,536,118427-55-7( MK-886 Sodium Salt). Grades: 98%. CAS No. 118414-82-7. Molecular formula: C27H34ClNO2S. Mole weight: 472.08. | |
| MK-886 (3-[tert-Butylthio-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic Acid, Sodium Salt) | Binds to 5-lipoxygenase-activating protein with high affinity and prevents the activation of 5-lipoxygenase, thus inhibiting the biosynthesis of leukotrienes. Group: Biochemicals. Alternative Names: 3-[tert-Butylthio-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic Acid, Sodium Salt. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| MK-886 sodium salt | MK-886 sodium salt. Group: Biochemicals. Alternative Names: 3-[tert-Butylthio-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic acid, sodium salt. Grades: Highly Purified. CAS No. 118427-55-7. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C27H33ClNNaO2S. US Biological Life Sciences. | Worldwide |
| MK-886 sodium salt | MK-886 is a leukotriene inhibitor that works by blocking 5-lipoxygenase activating protein (FLAP). MK886 also inhibits PPAR alpha by a non-competitive mechanism. Uses: Lipoxygenase inhibitors. Synonyms: MK-886 sodium; MK 886 sodium; MK886 sodium; 3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-2,2-dimethylpropanoate sodium salt. Grades: ≥99%. CAS No. 118427-55-7. Molecular formula: C27H33ClNO2S·Na. Mole weight: 494.1. | |
| MK 886 Sodium Salt (3-(1-(4-chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid, L 663536, L-663536, MK-886) | MK 886 Sodium Salt (3-(1-(4-chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid, L 663536, L-663536, MK-886). Group: Biochemicals. Alternative Names: Sodium;3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-2,2-dimethylpropanoate. Grades: Highly Purified. CAS No. 118427-55-7. Pack Sizes: 25mg. Molecular Formula: C27 H33 ClNO 2 , Molecular Weight: 494.1. US Biological Life Sciences. | Worldwide |
| Mk-912 hydrate | Heterocyclic Organic Compound. CAS No. 119942-70-0. Molecular formula: C20H25N3O2??·HCl??·xH2O. Mole weight: 375.89 (anhydrous ba. Catalog: ACM119942700. | |
| MK-912 hydrochloride | MK-912 is a potent new selective alpha 2-adrenergic receptor antagonist that is originated by Merck & Co for the treatment of Major depressive disorder. In Dec 1999, Phase-II clinical trials for Depression in USA was on going, but now it is discontinued. Uses: Major depressive disorder. Synonyms: MK912; MK 912; MK-912. 1',3'-dimethylspiro[1,3,4,6,7,12b-hexahydro-[1]benzofuro[2,3-a]quinolizine-2,4'-1,3-diazinane]-2'-one;hydrochloride. Grades: 98%. CAS No. 119942-70-0. Molecular formula: C20H26ClN3O2. Mole weight: 375.90. | |
| MK940 | MK940 is a potential central nervous system agent. It is used as an anti-depressant. Uses: Mk940 is used as an anti-depressant. Synonyms: MK-940; MK 940; 5-[3-(Methylamino)propyl]-10,11-dihydro-5H-5,10-epoxydibenzo[a,d][7]annulen-11-ol; trans-10,11-Dihydro-5,10-epoxy-5-(3-(methylamino)propyl)-5H-dibenzo(a,d)cyclohepten-11-ol hydrogen maleate. Grades: 98%. CAS No. 5154-92-7. Molecular formula: C19H21NO2. Mole weight: 295.38. | |
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