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MLKL Inhibitor, Necrosulfonamide ((E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide, Mixed Lineage Kinase Domain-like Protein Inhibitor, Necrosome Inhibitor II, Necrosulfonamide)
A cell-permeable acrylamide compound that inhibits human, but not murine, MLKL adaptor function via covalent modification of Cys86 and is more potent than Nec-1 in preventing necrotic/necroptotic death in human HT-29 (IC50 = 124nM and 2uM, respectively), being ineffective against necrosis/necroptosis in murine L929 or apoptosis in human RIP3-null Panc-1 cells. Unlike Nec-1, which prevents necrosome formation by blocking RIP1-RIP3 interaction, MLKL prevents the MLKL-RIP1-RIP3 necrosome complex from interacting with further downstream effectors. Group: Biochemicals. Grades: Highly Purified. CAS No. 432531-71-0. Pack Sizes: 25mg. Molecular Formula: C??H??N?O?S?, Primary Target: human MLKL. US Biological Life Sciences.
Worldwide
MLN0128
MLN0128, also known as INK128, is a TORC1/2 inhibitor, is also an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity. TORC1/2 inhibitor INK128 binds to and inhibits both TORC1 and TORC2 complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. TORC1 and 2 are upregulated in some tumors and play an important role in the PI3K/Akt/mTOR signaling pathway, which is frequently dysregulated in human cancers. Synonyms: TAK-228; TAK 228; TAK228; INK128; INK-128; INK 128; MLN0128; MLN 0128; MLN-0128; Sapanisertib. Grades: >98%. CAS No. 1224844-38-5. Molecular formula: C15H15N7O. Mole weight: 309.333.
MLN0905
MLN0905 is a potent, selective small-molecule PLK1 inhibitor. MLN0905 inhibits cell proliferation in a broad range of human tumor cells including DLBCL cell lines. PLK1 inhibition leads to pharmacodynamic pHisH3 modulation and significant antitumor activity in multiple DLBCL models. These data strongly suggest evaluating PLK1 inhibitors as DLBCL anticancer agents in the clinic. Synonyms: MLN0905; MLN0905; MLN0905. CAS No. 1228960-69-7. Molecular formula: C24H25F3N6S. Mole weight: 486.561.
MLN1117
MLN1117, also known as INK1117, is a PI3Kα inhibitor which could lead to the apoptosis and growth retardation of tumor cells expressed by PI3K&alpha. IC50: 15 nM. Uses: Mln1117 is a pi3kα inhibitor which could lead to the apoptosis and growth retardation of tumor cells expressed by pi3k&alpha. Synonyms: INK1117; INK-1117; INK 1117; MLN1117; MLN 1117; MLN-1117; TAK-117; TAK 117; TAK117; Serabelisib; [6-(2-amino-1,3-benzoxazol-5-yl)imidazo[1,2-a]pyridin-3-yl]-morpholin-4-ylmethanone;Serabelisib. Grades: 98%. CAS No. 1268454-23-4. Molecular formula: C19H17N5O3. Mole weight: 363.37.
MLN120B
MLN120B is a potent and effective IKKbeta inhibitor. It is currently being explored for treatment of inflammatory diseases such as COPD and asthma. Synonyms: MLN-120B; MLN120B; MLN 120B. Grades: >98%. CAS No. 783348-36-7. Molecular formula: C19H15ClN4O2. Mole weight: 366.8.
MLN2480
MLN2480 is an oral, selective pan-Raf kinase inhibitor. The Raf kinases (A-Raf, B-Raf and C-Raf) are key regulators of cell proliferation and survival within the mitogen-activated protein kinase (MAPK) pathway. The MAPK pathway is frequently disregulated in human cancers, often via activating mutations of Ras or Raf. Synonyms: TAK-580; TAK 580; TAK580; MLN 2480; MLN-2480; MLN2480; AMG 2112819; AMG2112819; AMG-2112819. Grades: >98%. CAS No. 1096708-71-2. Molecular formula: C17H12Cl2F3N7O2S. Mole weight: 506.29.
MLN 4924
A potent and selective inhibitor of NAE. Group: Biochemicals. Alternative Names: Sulfamic Acid [ (1S, 2S, 4R) -4- [4- [ [ (1S) -2, 3-dihydro-1H-inden-1-yl] amino] -7H-pyrrolo [2, 3-d] pyrimidin-7-yl] -2-hydroxycyclopentyl] methyl Ester. Grades: Highly Purified. CAS No. 905579-51-3. Pack Sizes: 1mg, 2mg, 5mg, 10mg. US Biological Life Sciences.
Worldwide
MLN4924 HCl
MLN4924 HCl is a potent and selective small molecule NEDD8-activating enzyme (NAE) inhibitor with an IC50 of 4.7 nM. Synonyms: MLN4924 HCl; MLN 4924 HCl; MLN-4924 HCl. Grades: >98%. CAS No. 1160295-21-5. Molecular formula: C21H26ClN5O4S. Mole weight: 479.98.
MLN8054
MLN8054 is a potent, selective and orally available aurora A kinase inhibitor with an IC 50 of 4 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 869363-13-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10180.
MLN8054
MLN8054 is an aurora kinase inhibitor MLN8054, which is an orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase with potential antineoplastic activity. Auora kinase inhibitor MLN8054 binds to and inhibits Aurora kinase A, resulting in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregration, and inhibition of cell proliferation. Aurora A localizes in mitosis to the spindle poles and to spindle microtubules and is thought to regulate spindle assembly. Aberrant expression of Aurora kinases occurs in a wide variety of cancers, including colon and breast cancers. Synonyms: MLN8054; MLN 8054; MLN-8054. CAS No. 869363-13-3. Molecular formula: C25H15ClF2N4O2. Mole weight: 476.86.
MLN 8054
An Aurora kinase inhibitor, used to treat patients with advanced solid tumors. Group: Biochemicals. Alternative Names: 4-[[9-Chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic Acid. Grades: Highly Purified. CAS No. 869363-13-3. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
MLN 8237
Antagonist of Aurora A serine/threonine protein kinase; antineoplastic. Group: Biochemicals. Alternative Names: 4-[[9-Chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxy-benzoic acid; Alisertib. Grades: Highly Purified. CAS No. 1028486-01-2. Pack Sizes: 10mg. Molecular Formula: C27H20ClFN4O4, Molecular Weight: 518.92. US Biological Life Sciences.
Worldwide
MLN-9708
ixazomib is an orally bioavailable second generation proteasome inhibitor (PI) with potential antineoplastic activity. Ixazomib inhibits the activity of the proteasome, blocking the targeted proteolysis normally performed by the proteasome, which results in an accumulation of unwanted or misfolded proteins; disruption of various cell signaling pathways may follow, resulting in the induction of apoptosis. Compared to first generation PIs, second generation PIs may have an improved pharmacokinetic profile with increased potency and less toxicity. Proteasomes are large protease complexes that degrade unneeded or damaged proteins that have been ubiquinated. Synonyms: Ixazomib; MLN-9708; MLN 9708; MLN9708. CAS No. 1201902-80-8. Molecular formula: C20H23BCl2N2O9. Mole weight: 517.12.
M-Loxoprofen
M-Loxoprofen. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1026471-88-4. Molecular Formula: C15H18O3. Mole Weight: 246.31. Catalog: APB1026471884.
MLR 1023
MLR 1023. Group: Biochemicals. Grades: Purified. CAS No. 41964-07-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
MLR 1023
Tolimidone is an allosteric Lyn kinase activator with EC50 value of 63 nM. It has been shown to reduce blood glucose levels in mice. Synonyms: Tolimidone; CP 26,154; CP 26,154; CP 26,154; NSC 314335; MLR-1023; MLR 1023; MLR1023. 5-(3-Methylphenoxy)-2(1H)-pyrimidinone. Grades: ≥99% by HPLC. CAS No. 41964-07-2. Molecular formula: C11H10N2O2. Mole weight: 202.21.
MLR-52
MLR-52, extracted from Streptomyces sp. AB 1869R-359, is an immunosuppressive protein kinase C inhibitor. And the IC50 (nmol/L) of the mixed lymphocyte response test was 1.9±0.2. Synonyms: 4'-Demethylamino-4',5'-dihydroxystaurosporine; (+)-MLR-52. CAS No. 155416-34-5. Molecular formula: C27H23N3O5. Mole weight: 469.49.
ML RR-S2 CDA
ML RR-S2 CDA, a synthetic CDN-derivative molecule, compared to endogenous and pathogen-derived CDNs, as a attractive compound for anticancer clinical development, it improves both stability and lipophilicity, promoting significantly increased STING signal. Synonyms: 2',3'-c-di-AM(PS)2(Rp,Rp); Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'?5')-, cyclic nucleotide; (R,R)-(2',3')c-diAM(PS)2; (2',3')-Rp,Rp-c-diAMPSS; dithio-(RP, RP)-[cyclic[A(2',5')pA(3',5')p]]; ML RR-S2 CDA (STING-Inducer-1). Grades: ≥95%. CAS No. 1638241-89-0. Molecular formula: C20H24N10O10P2S2. Mole weight: 690.54.
MLS1547
MLS1547 is a highly efficacious D2 dopamine receptor (D2R) G protein-biased agonist that does not recruit β-arrestin, and is an antagonist of dopamine-stimulated β-arrestin recruitment to the D2 receptor. Uses: Designed for use in research and industrial production. Additional or Alternative Names: MLS1547; MLS-1547; MLS 1547; MLS000051547. Product Category: Agonists. Appearance: Solid powder. CAS No. 315698-36-3. Molecular formula: C19H19ClN4O. Mole weight: 354.84. Purity: >98%. IUPACName: 5-Chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol. Canonical SMILES: OC1=C2N=CC=CC2=C(Cl)C=C1CN3CCN(C4=NC=CC=C4)CC3. Product ID: ACM315698363. Alfa Chemistry ISO 9001:2015 Certified.
MLS 1547
MLS 1547 is a dopamine D2 receptor agonist. It may be used in the combination with antipsychotic drugs. Synonyms: MLS 1547; MLS1547; MLS-1547; 5-Chloro-7-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-8-quinolinol. Grades: ≥98% by HPLC. CAS No. 315698-36-3. Molecular formula: C19H19ClN4O. Mole weight: 354.83.
MLS-573151
MLS-573151 is a specific and cell-permeable inhibitor of Cdc42, a GTPase of the Rho family. Synonyms: 4-(3,5-Diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide. Grades: ≥98%. CAS No. 10179-57-4. Molecular formula: C21H19N3O2S. Mole weight: 377.5.
ML SA1
ML SA1. Group: Biochemicals. Grades: Purified. CAS No. 332382-54-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
ML SA1
ML SA1 is an activator of TRPML channels. It can induce TRPML-mediated Ca2+ release from lysosomes and reduce cholesterol accumulation in Niemann-Pick type C macrophages. Synonyms: 2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione. Grades: ≥99% by HPLC. CAS No. 332382-54-4. Molecular formula: C22H22N2O3. Mole weight: 362.42.
ML-SI3
ML-SI3 is an antagonist of the TRPML family of calcium channels. ML-SI3 can prevent lysosomal calcium efflux and has been reported to block downstream TRPML1-mediated induction of autophagy. Synonyms: N- [2- [4- (2-methoxyphenyl) -1-piperazinyl] cyclohexyl] benzenesulfonamide. CAS No. 891016-02-7. Molecular formula: C23H31N3O3S. Mole weight: 429.58.
ML-SI3
ML-SI3 is a chemical compound which acts as an "antagonist" (i.e. channel blocker) of the TRPML family of calcium channels, with greatest activity at the TRPML1 channel, although it also blocks the related TRPML2 and TRPML3 channels with lower affinity. It is used for research into the role of TRPML1 and its various functions in lysosomes and elsewhere in the body. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ML-SI3; ML SI3; MLSI3; ML SI 3; MLSI-3. Product Category: Antagonists. Appearance: Solid powder. CAS No. 891016-02-7. Molecular formula: C23H31N3O3S. Mole weight: 429.58. Purity: >98%. IUPACName: N-(2-[4-(2-Methoxyphenyl)-1-piperazinyl]cyclohexyl)benzenesulfonamide. Canonical SMILES: O=S(C1=CC=CC=C1)(NC2C(N3CCN(C4=CC=CC=C4OC)CC3)CCCC2)=O. Product ID: ACM891016027. Alfa Chemistry ISO 9001:2015 Certified.
MLT-747
MLT-747 is a potent and selective malt1 peptide cleavage inhibitor. Synonyms: AC-31545; HY-124587; MLT 747; MLT747. Grades: ≥98% by HPLC. CAS No. 2097853-86-4. Molecular formula: C20H21Cl2N7O3. Mole weight: 478.3.
MLT-748
MLT-748 is a potent and selective malt1 peptide cleavage inhibitor. Synonyms: 1-(5-Chloro-6-(2H-1,2,3-Triazol-2-Yl)Pyridin-3-Yl)-3-(2-Chloro-7-((1R,2R)-1,2-Dimethoxypropyl)Pyrazolo[1,5-A]Pyrimidin-6-Yl)Urea. Grades: ≥98% by HPLC. CAS No. 1832578-30-9. Molecular formula: C19H19Cl2N9O3. Mole weight: 492.3.
Mlu I
One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 20-fold overdigestion with enzyme 95% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 1000U; 5000U. A↑CGCGT TGCGC↓A. Activity: 20000u.a./ml. Appearance: 10 X SE-buffer O. Storage: -20°C. Form: Liquid. Source: Micrococcus luteus. Pack: 10 mM Tris-HCl (pH 7.5); 100 mM NaCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1133RE.
Mly113 I
One unit of the enzyme is the amount required to hydrolyze 1 μg of T7 DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 3-fold overdigestion with enzyme more than 80% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 200U; 1000U. GG↑CGCC CCGC↓GG. Activity: 2000u.a./ml. Appearance: 10 X SE-buffer B. Storage: -20°C. Form: Liquid. Source: Micrococcus lylae 113. Pack: 10 mM Tris-HCl (pH 7.5); 50 mM KCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1134RE.
MM 102
MM 102. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
MM-102
MM-102, as a MLL1 mimetic, shows high binding affinities to WDR5 with IC50 of 2.9 nM and Ki of < 1 nM. Synonyms: MM-102; MM102; MM 102; HMTase Inhibitor IX. Grades:>98%. CAS No. 1417329-24-8. Molecular formula: C35H49F2N7O4. Mole weight: 669.8.
MM102 is a WDR5/MLL interaction inhibitor with IC50 value of 2.4 nM. It can inhibit cell growth and induce apoptosis in leukemia cells harbouring MLL1 fusion proteins. Synonyms: MM 102; MM102; MM-102; 1-[[(2S)-5-[(Aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]-cyclopentanecarboxamide trifluoroacetate. Grades: ≥98% by HPLC. CAS No. 1883545-52-5. Molecular formula: C35H49F2N7O4.CF3CO2H. Mole weight: 783.83.
MM 11253
MM 11253. Group: Biochemicals. Grades: Purified. CAS No. 345952-44-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
MM 11253
MM 11253 is a RARγ antagonist. It can block the growth inhibitory ability of RARγ-selective agonists in squamous cell carcinoma (SCC)-25 cells. Synonyms: MM 11253; MM-11253; MM11253. 6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylic acid. Grades: ≥98% by HPLC. CAS No. 345952-44-5. Molecular formula: C28H30O2S2. Mole weight: 462.67.
MM 14201
It is produced by the strain of Streptomyces sp. NCIB 11813. MM 14201 has a broad spectrum of antibacterial activity, especially against the bacteria of Serratia and Pseudomonas. Synonyms: MM-14201; 7-Oxabicyclo(4.1.0)hept-3-en-2-one, 3-amino-5-hydroxy-, (1S-(1alpha,5beta,6alpha))-. CAS No. 89020-30-4. Molecular formula: C6H7NO3. Mole weight: 141.12.
MM-17880
MM-17880 is originally isolated from Streptomyces olivaceus. It has anti-gram-positive and anti-gram-negative bacteria activities. Combined with amoxycillin, it has a synergistic antibacterial effect on Staphylococcus aureus and Klebsiella pneumoniae. Synonyms: (5R)-3-[[2-(Acetylamino)ethyl]thio]-6α-[(S)-1-(sulfooxy)ethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid disodium salt. CAS No. 61036-81-5. Molecular formula: C13H16N2Na2O8S2. Mole weight: 438.38.
MM-206
MM-206 is a cell-permeable STAT3 inhibitor. Synonyms: 2,3,4,5,6-Pentafluoro-N-(4-hydroxy-3-phenylsulfanylnaphthalen-1-yl)benzenesulfonamide. Grades: ≥98%. CAS No. 1809581-87-0. Molecular formula: C22H12F5NO3S2. Mole weight: 497.5.
MM-22
MM-22 is a biotinylated anandamide analog. It can block anandamide uptake with IC50 value of 0.5 μM in HaCaT cells. Synonyms: MM-22; MM 22; MM22; (3aS,4S,6aR)-Hexahydro-2-oxo-N-[2-[2-[2-[[(5Z,8Z,11Z,14Z)-1-oxo-5,8,11,14-eicosatetraen-1-yl]amino]ethoxy]ethoxy]ethyl]-1H-thieno[3,4-d]imidazole-4-pentanamide. Grades: ≥98% by HPLC. CAS No. 956605-71-3. Molecular formula: C36H60N4O5S. Mole weight: 660.95.
Mm 2,4-dimercapto-5,6-diaminopyrimidine
Mm 2,4-dimercapto-5,6-diaminopyrimidine. Uses: For analytical and research use. Group: Impurity standards. CAS No. 31295-41-7. Molecular Formula: C4H6N4S2. Mole Weight: 174.24. Catalog: APB31295417.
MM-401 TFA
MM-401 (TFA) is a MLL1 H3K4 methyltransferase inhibitor. MM-401 inhibits MLL1 activity ( IC 50 = 0.32 μM) by blocking MLL1-WDR5 interaction. MM-401 can induce cell cycle arrest, apoptosis and differentiation. MM-401 can be used for the research of MLL leukemia [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1442106-11-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-19554A.
MM-419447 (Linaclotide Metabolite) Trifluoroacetic acid is a metabolite of Linaclotide, which is a peptide agonist of guanylate cyclase 2C used to treat abdominal pain associated with constipation in patients with irritable bowel syndrome (IBS). Synonyms: L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteine trifluoroacetic acid; L-Cysteine, L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-, trifluoroacetic acid (1:x); H-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-OH.TFA. Grades: 97%. Molecular formula: C50H76N14O19S6.xC2HF3O2. Mole weight: 1369.61 (free base).
MM 42842
MM 42842 is originally isolated from Pseudomonas cocovenenans and has weak activity against gram-positive bacteria. Synonyms: MM-42842. Grades: >98%. CAS No. 113784-28-4. Molecular formula: C13H22N4O9S. Mole weight: 410.40.
MM 46115
MM 46115 is produced by the strain of Actinomadura pelletieri. It has anti-parainfluenza virus 1 and 2 and anti-gram-positive bacteria activities. Synonyms: MM-46115; 17-O-(4-((3-Chloro-6-hydroxy-2-methylbenzoyl)amino)-2,3,4,6-tetradeoxy-3-(dimethylamino)-beta-D-lyxo-hexopyranosyl)-22-de(hydroxymethyl)-8,14,23-tridemethyl-12-ethyl-8-hydroxy-23-propylkijanolide. CAS No. 132054-37-6. Molecular formula: C50H67ClN2O10. Mole weight: 891.52.
MM 47755
MM 47755 is produced by the strain of greysporing streptomycete. It has anti-Gram-negative bacteria and fungi activity (100μg/ mL). Synonyms: 6-Deoxy-8-O-methylrabelomycin; (-)-3,4-Dihydro-3-hydroxy-8-methoxy-3-methylbenz(a)anthracene-1,7,12(2H)-trione; MM-47755; Benz(a)anthracene-1,7,12(2H)-trione, 3,4-dihydro-3-hydroxy-8-methoxy-3-methyl-, (-)-. Grades: 95%. CAS No. 117620-87-8. Molecular formula: C20H16O5. Mole weight: 336.34.
MM 47755 (6-Desoxy-8-O-methylrabelomycin; (R)-3-Hydroxy-8-methoxy-3-methyl-3,4-dihydro-tetraphene-1,7,12(2H)-trione)
Antibiotic. Angucyclinone. Antibacterial and antifungal. Group: Biochemicals. Grades: Highly Purified. CAS No. 117620-87-8. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
MM 49721
It is a kind of glycopeptide antibiotic originally isolated from Amycolatatopsis orientalis NCIB 12608 with good activity against Gram-positive bacteria. Synonyms: MM-49721; Vancomycin, 22-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-D-arabino-hexopyranosyl)-2'-O-de(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-10,19-didechloro-2'-O-(6-deoxy-alpha-D-talopyranosyl)-. CAS No. 126985-52-2. Molecular formula: C72H87N9O28. Mole weight: 1526.50.
MM 54
MM 54 (compound 5) is a competitive antagonist at APJ , with an IC 50 of 93 nM. MM 54 behaves as a potent and selective inhibitor of apelin binding and APLNR activation [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 1313027-43-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2271.
MM 54
MM 54 is an apelin receptor antagonist with IC50 value of 93 nM. It can antagonize the inhibitory effect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells. Synonyms: MM-54; MM54; H-Cys(1)-Arg-Pro-Arg-Leu-Cys(1)-Lys-His-Cys(2)-Arg-Pro-Arg-Leu-Cys(2)-OH; L-cysteinyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-cysteinyl-L-lysyl-L-histidyl-L-cysteinyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-cysteine (1->6),(9->14)-bis(disulfide). Grades: ≥95%. CAS No. 1313027-43-8. Molecular formula: C70H121N29O15S4. Mole weight: 1737.15.
MM 55266
It is a kind of glycopeptide antibiotic originally isolated from Amycolatopsis NCIB 40089 with good activity against Gram-positive bacteria. Synonyms: MM-55266; Ristomycin A aglycone, 5,22,31,45,55-pentachloro-7-demethyl-64-O-demethyl-34-O-(2-deoxy-2-((7-methyl-1-oxooctyl)amino)-alpha-D-glucopyranuronosyl)-44-O-beta-D-glucopyranosyl-56-O-beta-D-mannopyranosyl-N15-methyl-. CAS No. 137053-20-4. Molecular formula: C86H89Cl5N8O35. Mole weight: 1971.92.
MM-55268
It is a kind of glycopeptide antibiotic originally isolated from Amycolatopsis NCIB 40089 with good activity against Gram-positive bacteria. Synonyms: Ristomycin A aglycone, 5,22,31,45,55-pentachloro-7-demethyl-64-O-demethyl-34-O-((2-deoxy-2-((1-oxodecyl)amino)-alpha-D-glucopyranuronosyl)amino)-44-O-beta-D-glucopyranosyl-56-O-beta-D-mannopyranosyl-N15-methyl-. CAS No. 137053-19-1. Molecular formula: C87H91Cl5N8O35. Mole weight: 1985.95.
MM 77 dihydrochloride
MM 77 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 159187-70-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
MM 77 dihydrochloride
MM 77 dihydrochloride is a 5-HT1A receptor antagonist. Uses: Serotonin 5-ht1 receptor antagonists. Synonyms: MM 77 dihydrochloride; MM77 dihydrochloride; MM-77 dihydrochloride; 1-(2-Methoxyphenyl)-4-(4-succinimidobutyl)piperazine dihydrochloride. Grades: ≥95%. CAS No. 159187-70-9. Molecular formula: C19H27N3O3.2HCl. Mole weight: 418.36.
MMAE-d8
MMAE-d 8 is a deuterated labeled MMAE, a potent mitotic inhibitor and a tubulin inhibitor. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: Monomethyl auristatin E-d8; Deuterated labeled MMAE. CAS No. 2070009-72-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-15162A.
MMAF Hydrochloride
MMAF Hydrochloride, a synthetic antineoplastic agent, is a tubulin polymerization inhibitor that inhibits cell division by blocking the polymerization of tubulin. It is part of some experimental anti-cancer antibody-drug conjugates such as vorsetuzumab mafodotin and SGN-CD19A. Uses: Adcs cytotoxin. Synonyms: Monomethylauristatin F Hydrochloride; Monomethyl Auristatin F Hydrochloride; N-Methyl-L-valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(αR,βR,2S)-β-methoxy-α-methyl-2-pyrrolidinepropanoyl-L-phenylalanine Hydrochloride; Monomethylauristatin Phenylalanine Hydrochloride; L-Valinamide, N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1S)-1-carboxy-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-, Hydrochloride (1:1); ((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoyl)-L-phenylalanine Hydrochloride. Grades: >98%. CAS No. 1415246-68-2. Molecular formula: C39H66ClN5O8. Mole weight: 768.42.
MMAI
MMAI is a selective serotonin releaser that can be used in the research of mental illnesses [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 5-Methoxy-6-methyl-2-aminoindan. CAS No. 136468-19-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-W100249.
m,m'-Ditolylamine
m,m'-Ditolylamine. Group: Small molecule semiconductor building blockselectroluminescence materials polymers. CAS No. 626-13-1. Product ID: 3-methyl-N-(3-methylphenyl)aniline. Molecular formula: 197.27g/mol. Mole weight: C14H15N. CC1=CC(=CC=C1)NC2=CC=CC(=C2)C. InChI=1S/C14H15N/c1-11-5-3-7-13 (9-11)15-14-8-4-6-12 (2)10-14/h3-10, 15H, 1-2H3. CWVPIIWMONJVGG-UHFFFAOYSA-N.
m-Methoxytopolin
m-Methoxytopolin. Group: Biochemicals. Grades: Highly Purified. CAS No. 75737-39-2. Pack Sizes: 250mg, 500mg, 1g. Molecular Formula: C13H13N5O. US Biological Life Sciences.
Worldwide
m-Methoxytopolin-9-glucoside
m-Methoxytopolin-9-glucoside is an intricate and potent bioactive compound, used for studying a myriad of afflictions including cancer, inflammation and neurodegenerative disorders. Synonyms: 6-(3-Methoxybenzylamino)-9-b-Dglucopyranosylpurine. CAS No. 1226978-21-7. Molecular formula: C19H23N5O6. Mole weight: 417.42.
m-Methoxytopolin riboside
It can be used in biological study in influence of plant growth regulators on shoot proliferation and secondary metabolite production in micropropagated Huernia hystrix. Synonyms: N6-(m-Methoxybenzyl)adenosine; Mem-TR; 6-(3-Methoxybenzylamino)-9-b-D-ribofuranosylpurine; N6-(3-Methoxybenzyl)adenosine; N-(3-Methoxybenzyl)adenosine; (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-((3-methoxybenzyl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diol; meta-Methoxytopolin Riboside; N-[(3-Methoxyphenyl)methyl]adenosine. Grades: ≥95%. CAS No. 101565-95-1. Molecular formula: C18H21N5O5. Mole weight: 387.39.
m-Methyl Atomoxetine Hydrochloride
m-Methyl Atomoxetine Hydrochloride. Group: Biochemicals. Alternative Names: N-Methyl-γ - (3-methylphenoxy) benzenepropanamine Hydrochloride; Atomoxetine Related Compound B Hydrochloride. Grades: Highly Purified. CAS No. 873310-28-2. Pack Sizes: 2.5mg. Molecular Formula: C17H22ClNO, Molecular Weight: 291.82. US Biological Life Sciences.
Worldwide
m-Methyl Atomoxetine Hydrochloride
M-Methyl Atomoxetine Hydrochloride is an impurity of Atomoxetine, which is a selective norepinephrine (NE) reuptake inhibitor for the treatment of attention-deficit hyperactivity disorder (ADHD). Synonyms: N-Methyl-γ-(3-methylphenoxy)benzenepropanamine Hydrochloride; Atomoxetine Related Compound B Hydrochloride; rac-Atomoxetine EP Impurity D HCl; Atomoxetine USP Related Compound B; N-methyl-3-phenyl-3-(m-tolyloxy)propan-1-amine hydrochloride (1:1). Grades: ≥90%. CAS No. 873310-28-2. Molecular formula: C17H22ClNO. Mole weight: 291.81.
MMF
MMF. Group: Biochemicals. Grades: Purified. CAS No. 2756-87-8. Pack Sizes: 50mg. US Biological Life Sciences.
Worldwide
MMGP1
MMGP1 is an antifungal peptide which was found to possess potent antifungal activity against C. albicans.
MMK 1
MMK 1. Group: Biochemicals. Grades: Purified. CAS No. 271246-66-3. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
MMK 1
MMK 1 is a potent and selective human formyl peptide receptor FPR2 agonist (EC50 = 1, 2 and > 10 000 nM at mFRP2, hFPR2 and hFPR1 respectively). Some findings showed that the transient rise in intracellular free calcium induced by MMK-1 involves both a release of calcium from intracellular stores and an opening of channels in the plasma membrane. Synonyms: MMK 1; MMK1; MMK-1; (4S)-4-[[(2S)-2-amino-4-methylpentanoyl]amino]-5-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(1S)-1-carboxy-3-methylsulfanylpropyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-5-oxopentanoic acid. CAS No. 271246-66-3. Molecular formula: C75H123N19O18S. Mole weight: 1610.97.
MMP-13 Inhibitor
MMP-13 Inhibitor is a potent and selective inhibitor of matrix metalloproteinase-13 (MMP-13) with IC50 value of 8 nM. Synonyms: Collagenase-3 Inhibitor; Matrix Metalloproteinase-13 Inhibitor; 4,6-Pyrimidinedicarboxamide; N4,N6-Bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-dicarboxamide. Grades: ≥98%. CAS No. 544678-85-5. Molecular formula: C22H20F2N4O2. Mole weight: 410.4.
MMP2-IN-3
MMP2-IN-3 (compound 2) is a potent MMP-2 (matrix metalloproteinases) inhibitor, with an IC 50 of 31 μM. MMP2-IN-3 also shows inhibitory activity against MMP-9 and MMP-8 , with IC 50 values of 26.6, and 32 μM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 897799-81-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-147746.
MMP-2 Inhibitor I
MMP-2 Inhibitor I is a reversible inhibitor of matrix metalloproteinase 2 (MMP-2) with Ki value of 1.6 μM. It attenuates cancer cell migration via inhibition of MMP-2. Synonyms: ?Matrix Metalloproteinase-2 Inhibitor I; cis-9-Octadecenoyl-N-hydroxylamide; Oleylhydroxamate; N-Hydroxyoleamide; OA-Hy; Oleoyl-N-hydroxylamide. Grades: ≥98%. CAS No. 10335-69-0. Molecular formula: C18H35NO2. Mole weight: 297.5.
MMP-2 Inhibitor II
MMP-2 Inhibitor II is an irreversible inhibitor of matrix metalloproteinase-2 (MMP-2) with Ki value of 2.4 μM. It also less potently inhibits MMP-1 and MMP-7. Synonyms: ?Matrix Metalloproteinase-2 Inhibitor II; (4- (4- (Methanesulfonamido) phenoxy) phenylsulfonyl) methyloxirane. Grades: ≥98%. CAS No. 869577-51-5. Molecular formula: C16H17NO6S2. Mole weight: 383.4.